WO2018088734A3 - Globular structure containing novel protein transduction domain - Google Patents

Globular structure containing novel protein transduction domain Download PDF

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Publication number
WO2018088734A3
WO2018088734A3 PCT/KR2017/011917 KR2017011917W WO2018088734A3 WO 2018088734 A3 WO2018088734 A3 WO 2018088734A3 KR 2017011917 W KR2017011917 W KR 2017011917W WO 2018088734 A3 WO2018088734 A3 WO 2018088734A3
Authority
WO
WIPO (PCT)
Prior art keywords
globular structure
protein transduction
novel protein
structure containing
transduction domain
Prior art date
Application number
PCT/KR2017/011917
Other languages
French (fr)
Korean (ko)
Other versions
WO2018088734A2 (en
Inventor
장상호
이길환
황정순
김지안
박주희
이정옥
조현종
정재영
Original Assignee
주식회사 바이오셀트란
제이앤팜유한책임회사
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 주식회사 바이오셀트란, 제이앤팜유한책임회사 filed Critical 주식회사 바이오셀트란
Publication of WO2018088734A2 publication Critical patent/WO2018088734A2/en
Publication of WO2018088734A3 publication Critical patent/WO2018088734A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/14—Liposomes; Vesicles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/55—Phosphorus compounds
    • A61K8/553—Phospholipids, e.g. lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Birds (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)

Abstract

The present invention relates to a globular structure in which novel protein transduction domains are self-assembled. By using the peptide having the amino acid sequence of SEQ ID NO: 1 of the present invention, a globular structure (e.g., liposomes) having improved permeability to cells or the skin can be constructed. In addition, the globular structure (e.g., liposomes) constructed in the present invention can be used to have a sparingly soluble material (skin functional substance or pharmacologically effective substance) loaded therein and to effectively transport the material into the skin or cells.
PCT/KR2017/011917 2016-11-10 2017-10-26 Globular structure containing novel protein transduction domain WO2018088734A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020160149622A KR101797168B1 (en) 2016-11-10 2016-11-10 Vesicle with novel protein transduction domain
KR10-2016-0149622 2016-11-10

Publications (2)

Publication Number Publication Date
WO2018088734A2 WO2018088734A2 (en) 2018-05-17
WO2018088734A3 true WO2018088734A3 (en) 2018-08-09

Family

ID=60385914

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2017/011917 WO2018088734A2 (en) 2016-11-10 2017-10-26 Globular structure containing novel protein transduction domain

Country Status (2)

Country Link
KR (1) KR101797168B1 (en)
WO (1) WO2018088734A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102246906B1 (en) * 2019-04-29 2021-04-30 주식회사 바이오셀트란 Cosmetic composition for anti-wrinkle with high skin or cell penetration capacity

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20030018549A (en) * 2001-08-30 2003-03-06 동국제약 주식회사 Liposome for Containing Anion Polymer and Phospholipid and Manufacturing Method the Same and Application
KR20080004997A (en) * 2006-07-07 2008-01-10 조선대학교산학협력단 A novel antimicrobial peptide pep-1-k designed from the cell-penetrating peptide pep-1 and uses thereof
KR20090122769A (en) * 2008-05-26 2009-12-01 메디스커브 주식회사 Method for delivering proteins into cells and peptide therefor
KR20110046961A (en) * 2009-10-29 2011-05-06 중앙대학교 산학협력단 Cell penetrating peptide modified nanoliposome and anti-atopic composition comprising the same
KR20110071017A (en) * 2008-10-16 2011-06-27 마리나 바이오테크, 인크. Processes and compositions for liposomal and efficient delivery of gene silencing therapeutics

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20030018549A (en) * 2001-08-30 2003-03-06 동국제약 주식회사 Liposome for Containing Anion Polymer and Phospholipid and Manufacturing Method the Same and Application
KR20080004997A (en) * 2006-07-07 2008-01-10 조선대학교산학협력단 A novel antimicrobial peptide pep-1-k designed from the cell-penetrating peptide pep-1 and uses thereof
KR20090122769A (en) * 2008-05-26 2009-12-01 메디스커브 주식회사 Method for delivering proteins into cells and peptide therefor
KR20110071017A (en) * 2008-10-16 2011-06-27 마리나 바이오테크, 인크. Processes and compositions for liposomal and efficient delivery of gene silencing therapeutics
KR20110046961A (en) * 2009-10-29 2011-05-06 중앙대학교 산학협력단 Cell penetrating peptide modified nanoliposome and anti-atopic composition comprising the same

Also Published As

Publication number Publication date
KR101797168B1 (en) 2017-11-13
WO2018088734A2 (en) 2018-05-17

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