PE20190967A1 - MODIFIED ISOLATED STREPTOMYCES FUNGICIDICUS AND ITS USE - Google Patents
MODIFIED ISOLATED STREPTOMYCES FUNGICIDICUS AND ITS USEInfo
- Publication number
- PE20190967A1 PE20190967A1 PE2019001065A PE2019001065A PE20190967A1 PE 20190967 A1 PE20190967 A1 PE 20190967A1 PE 2019001065 A PE2019001065 A PE 2019001065A PE 2019001065 A PE2019001065 A PE 2019001065A PE 20190967 A1 PE20190967 A1 PE 20190967A1
- Authority
- PE
- Peru
- Prior art keywords
- streptomyces fungicidicus
- isolates
- compositions
- amino acid
- modified isolated
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/36—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Actinomyces; from Streptomyces (G)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Abstract
Referido a un aislado de Streptomyces fungicidicus modificado que codifica una proteina Orf2798 que tiene un 95% o mas de identidad de secuencia de aminoacidos con la secuencia SEQ ID NO:2 y comprende un residuo de serina en la posicion de aminoacido 2; obteniendose una produccion mejorada de enduracina (enramicina) en comparacion con el obtenido con una cepa Streptomyces fungicidicus de tipo silvestre. Tambien se refiere a composiciones que comprenden estos aislados, y metodos para usar tales aislados y composiciones para sintetizar biologicamente la enduracidina que facilitan su produccion de una manera mas eficienteReferred to a modified Streptomyces fungicidicus isolate encoding an Orf2798 protein that has a 95% or more amino acid sequence identity with the sequence SEQ ID NO: 2 and comprises a serine residue at amino acid position 2; obtaining an improved production of enduracin (enramycin) compared to that obtained with a Streptomyces fungicidicus strain of wild type. It also refers to compositions comprising these isolates, and methods for using such isolates and compositions to biologically synthesize enduracidin that facilitate their production in a more efficient manner.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662430455P | 2016-12-06 | 2016-12-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20190967A1 true PE20190967A1 (en) | 2019-07-08 |
Family
ID=60043150
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2019001065A PE20190967A1 (en) | 2016-12-06 | 2017-09-20 | MODIFIED ISOLATED STREPTOMYCES FUNGICIDICUS AND ITS USE |
Country Status (11)
| Country | Link |
|---|---|
| JP (2) | JP2020500509A (en) |
| CN (1) | CN110072881A (en) |
| BR (1) | BR112019011603A2 (en) |
| CO (1) | CO2019005540A2 (en) |
| MX (1) | MX2019006586A (en) |
| MY (1) | MY194438A (en) |
| PE (1) | PE20190967A1 (en) |
| PH (1) | PH12019501225A1 (en) |
| TW (1) | TWI770070B (en) |
| UA (1) | UA127451C2 (en) |
| WO (1) | WO2018103905A1 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11447530B2 (en) | 2016-12-06 | 2022-09-20 | Oregon State University | Compositions and methods for enhanced production of enduracidin in a genetically engineered strain of streptomyces fungicidicus |
| CN115261258A (en) * | 2022-06-07 | 2022-11-01 | 四川汇邦环保科技有限公司 | Microbial agent for degrading duramycin |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1617881C2 (en) | 1965-10-13 | 1984-07-05 | Takeda Chemical Industries, Ltd., Osaka | Antibiotic enduracidin and its manufacture |
| AT269354B (en) * | 1965-10-13 | 1969-03-10 | Takeda Chemical Industries Ltd | Process for the production of a new antibiotic |
| US3577530A (en) | 1969-07-24 | 1971-05-04 | Squibb & Sons Inc | Janiemycin |
| JPS6038120B2 (en) | 1980-10-31 | 1985-08-30 | 武田薬品工業株式会社 | Production method of the antibiotic enzyuracydin |
| WO2008054945A2 (en) * | 2006-09-29 | 2008-05-08 | State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University | Enduracidin biosynthetic gene cluster from streptomyces fungicidicus |
| CN101974469B (en) * | 2010-10-22 | 2012-05-23 | 安徽丰原发酵技术工程研究有限公司 | Streptomyces fungicidious mutant strain and application thereof |
| CN103374537B (en) * | 2012-04-25 | 2015-01-07 | 牡丹江佰佳信生物科技有限公司 | Method for preparing enduracidin and strain produced thereby |
| CN102864114B (en) * | 2012-10-19 | 2013-11-06 | 河北圣雪大成制药有限责任公司 | Strain for highly yielding enramycin, and preparation method and application thereof |
| CN103740612A (en) * | 2013-12-19 | 2014-04-23 | 河北圣雪大成制药有限责任公司 | High-yield enramycin strain and screening method thereof |
-
2017
- 2017-09-20 PE PE2019001065A patent/PE20190967A1/en unknown
- 2017-09-20 MY MYPI2019002918A patent/MY194438A/en unknown
- 2017-09-20 BR BR112019011603-6A patent/BR112019011603A2/en unknown
- 2017-09-20 JP JP2019524442A patent/JP2020500509A/en active Pending
- 2017-09-20 UA UAA201906560A patent/UA127451C2/en unknown
- 2017-09-20 MX MX2019006586A patent/MX2019006586A/en unknown
- 2017-09-20 CN CN201780073894.9A patent/CN110072881A/en active Pending
- 2017-09-20 WO PCT/EP2017/073771 patent/WO2018103905A1/en active Application Filing
- 2017-10-11 TW TW106134804A patent/TWI770070B/en active
-
2019
- 2019-05-28 CO CONC2019/0005540A patent/CO2019005540A2/en unknown
- 2019-05-31 PH PH12019501225A patent/PH12019501225A1/en unknown
-
2022
- 2022-11-10 JP JP2022180156A patent/JP2023012549A/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| RU2019117260A3 (en) | 2021-01-29 |
| TW201827590A (en) | 2018-08-01 |
| JP2020500509A (en) | 2020-01-16 |
| WO2018103905A1 (en) | 2018-06-14 |
| BR112019011603A2 (en) | 2020-08-18 |
| UA127451C2 (en) | 2023-08-30 |
| PH12019501225A1 (en) | 2019-09-23 |
| RU2019117260A (en) | 2021-01-11 |
| CN110072881A (en) | 2019-07-30 |
| MX2019006586A (en) | 2019-08-22 |
| TWI770070B (en) | 2022-07-11 |
| CO2019005540A2 (en) | 2019-05-31 |
| MY194438A (en) | 2022-11-30 |
| JP2023012549A (en) | 2023-01-25 |
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