WO2018088676A1

WO2018088676A1 - Needle disk roller device comprising viscoelastic connection cap structured to be forced against lower end of bottleneck

Info

Publication number: WO2018088676A1
Application number: PCT/KR2017/008228
Authority: WO
Inventors: 이창우
Original assignee: 이창우
Priority date: 2016-11-08
Filing date: 2017-07-31
Publication date: 2018-05-17
Also published as: CN108778396A; CN108778396B; KR101695603B1

Abstract

Disclosed is a needle disk roller device separably coupled to a medication bottle in which a liquid medication is stored, and which comprises a bottleneck having a predetermined inner diameter. The needle disk roller device comprises: a viscoelastic connection cap separably coupled to the medication bottle so as to cover the upper-end opening of the bottleneck; a roller guiding holder coupled to the upper end of the viscoelastic connection cap; a needle disk roller retained on the roller guiding holder to be able to move linearly; and a medication delivery mechanism for delivering the medication inside the medication bottle to the needle disk of the needle disk roller when the needle disk roller is pressurized against skin. The viscoelastic connection cap comprises: a lower outer barrel portion forced against the outer peripheral surface of the bottleneck when coupled to the upper end of the medication bottle; a lower inner barrel portion inserted into the opening of the medication bottle and forced against the inner peripheral surface of the bottleneck; and a planar ring portion forced against the upper end of the bottleneck so as to connect the inner periphery of the upper end of the lower outer barrel portion and the outer periphery of the upper end of the lower inner barrel portion. The lower inner barrel portion extends further downward past the lower end of the lower outer barrel portion and the lower end of the bottleneck.

Description

Needle disc roller device with viscoelastic connection cap with bottleneck bottom contact

The present invention relates to a needle disk roller device for forming fine needle holes in the skin using a needle disk roller and injecting drugs through the needle holes, and more particularly, connected to a medicine bottle while being connected to the needle disk roller. It relates to a needle disk roller device having a viscoelastic connection cap that is in close contact with the bottleneck top as well as the bottleneck bottom and the bottleneck inner surface.

Needle roller devices have been proposed in the past. This conventional needle roller device includes a member covering an opening formed at the top of a vial, which is formed to have an elastically deformable incision. Therefore, when the vial is inverted, the incision is pushed by the weight of the ball pre-installed near the incision and the opening is opened in only one direction. However, such a needle roller device is difficult to reliably deliver the drug to each of the needles in a delivery method in which the drug falls on the distant needle disk, and it is difficult to control the incision deformation by the ball weight, and the incision is permanently deformed as the service life increases. Thus, it could be in a state that can no longer be used.

In particular, the prior art has been inconvenient in coupling the needle disk roller with the vial. In addition, the conventional apparatus has a disadvantage that the assembly is bad because assembly of the assembly including the needle disk roller requires bolt fastening or adhesion.

On the other hand, the inventor of the present invention, the viscoelastic connection cap is detachably connected to the vial having an opening at the top of the bottleneck, the lower inner cylinder portion which is partly fitted into the bottleneck of the vial and close to the outside of the bottleneck of the vial It has been proposed a needle disk roller device that can be connected to the vials in a dual structure, including.

The needle disk roller device previously proposed by the present invention includes a hook portion that is elastically caught to a locking jaw at the top of a bottleneck of a vial at the bottom of the lower outer cylinder portion of the viscoelastic connection cap. However, such a viscoelastic connection cap, because the lower inner barrel is inserted only to the middle of the bottleneck of the bottle, it could not be firmly and stably coupled to the bottle, there is also a concern that the drug leakage through the micro-gap between the lower inner barrel and the bottle inner surface do.

Accordingly, the problem to be solved by the present invention is that the lower inner cylinder portion of the viscoelastic connection cap connecting the needle disk roller to the vial is extended to the lower end of the bottleneck to be in close contact with the lower end of the bottleneck, thereby making the viscoelasticity more stable and firm. In addition to ensuring the connection of the connection cap, to provide a needle disk roller device that can more strictly block the leakage of unwanted drugs.

According to one aspect of the present invention there is provided a needle disk roller device that is detachably coupled to a vial containing a bottle of liquid and having a bottleneck having a predetermined inner diameter. The needle disk roller device, the viscoelastic connecting cap detachably coupled to the vial to cover the top opening of the bottleneck; A roller guiding holder coupled to an upper end of the viscoelastic connection cap; A needle disk roller which is held in a linear movement with the roller guiding holder; And a drug delivery mechanism for delivering the drug in the vial to the needle disc of the needle disc roller when the needle disc roller is pressed against the skin, wherein the viscoelastic connection cap, when coupled to the top of the vial A lower outer cylinder portion in close contact with the outer circumferential surface of the bottleneck, a lower inner cylinder portion inserted into the opening of the vial bottle and in close contact with the inner circumferential surface of the bottleneck, connecting the upper inner circumference of the lower outer cylinder portion and the upper outer circumference of the lower inner cylinder portion, and the upper end of the bottleneck It includes a plate-like ring portion in close contact with, the lower inner cylinder portion extends further down past the lower end of the lower outer cylinder portion and the lower end of the bottleneck.

According to one embodiment, the lower inner cylinder portion has an annular projection projecting in the radial direction at the bottom, when the viscoelastic connecting cap is coupled to the vial, the annular projection is shrinkage deformation while passing through the bottleneck, With restoration, the bottleneck is in close contact with the extension below the bottleneck bottom.

According to one embodiment, the viscoelastic connection cap has an upper outer cylinder portion in close contact with the outer surface of the lower stepped jaw of the roller guiding holder, an upper inner cylinder portion formed inside the upper outer cylinder portion while having a concentric axis with the upper outer cylinder portion, and the upper portion And an annular retaining cover extending inwardly to the top of the outer cylinder portion, wherein the annular retaining cover is elastically deformed to fit the lower step of the roller guiding holder inward while the lower step is fitted in close contact with the upper surface of the lower step. And fix the roller guiding holder to the viscoelastic connection cap in a sealed state.

According to one embodiment, the viscoelastic connection cap integrally includes a valve membrane formed with a valve hole in the hollow inner portion of the upper inner cylinder portion, the needle disk roller is to move up and down linearly along the guide groove formed in the roller guiding holder A roller bracket to be installed, a core rotating shaft rotatably installed with respect to the roller bracket, a roller bobbin rotatably installed with respect to the core rotating shaft, and a plurality of annular needles rotating with respect to the core rotating shaft together with the roller bobbin. Discs, wherein the drug delivery mechanism includes a valve actuating portion for delivering drugs from the vial to the needle disc side in cooperation with the valve membrane, the valve actuating portion being inserted into the valve hole without any gap. A rod portion which moves up and down linearly integrally with the rod portion, A tapered press portion formed in the middle and gradually increasing in diameter from the lower end having the same diameter as the rod portion toward the upper end having a larger diameter than the rod portion, and the drug passing incision groove formed in the tapered press portion. And the tapered pressurizing portion presses the valve membrane, and the valve membrane is pushed by the tapered pressing portion to expand the valve hole, and the valve hole is cut by the tapered pressurizing portion. It opens in connection with the groove.

Needle disk roller device according to the present invention, the lower inner cylinder portion of the viscoelastic connection cap for connecting the needle disk roller to the vial is configured to extend to the lower end of the bottleneck to be in close contact with the lower end of the bottleneck, more stable and firm viscoelastic connection As well as ensuring the connection of the cap, it has the advantage of more strictly preventing the leakage of unwanted drugs.

Other advantages and effects of the present invention will be understood from the description of the following examples.

1 is a front view showing a needle disk roller device coupled to a vial in accordance with one embodiment of the present invention.

Figure 2 is an exploded enlarged cross-sectional view showing a needle disk roller device according to an embodiment of the present invention.

Figure 3 is an exploded cross-sectional view showing a needle disk roller device according to an embodiment of the present invention.

4 is a perspective view of the needle disk roller.

5 is an exploded perspective view showing the needle disk roller.

6 is a view for explaining the action of the drug delivery mechanism of the needle disk roller device.

Hereinafter, exemplary embodiments of the present invention will be described in detail with reference to the accompanying drawings. The accompanying drawings and a description thereof are provided for the purpose of helping those skilled in the art to understand the present invention. Accordingly, the drawings and description should not be interpreted as limiting the scope of the invention.

As shown in Figures 1 to 3, the needle disk roller device 1 according to an embodiment of the present invention is used in combination with the upper end of the vial (2) containing a liquid drug. The vial 2 includes a vertical bottleneck 2b having an opening at the top and having a constant inner diameter. An upper end of the bottleneck 2b is formed with an annular jaw 2a protruding in a radially outward direction, and an inner lower end of the bottleneck 2b is formed with an enlarged portion 2c larger than an inner diameter of the bottleneck 2b. . The expansion part 2c connects the inner surface of the bottleneck 2b with the inside of the body of the vial 2.

In addition, the needle disk roller device 1 is a viscoelastic connection cap 12 is coupled to cover the top opening of the vial (2), and the roller guiding holder 14 is coupled to the upper end of the viscoelastic connection cap 12 ), The needle disk roller 20 held in the roller guiding holder 14 so as to be movable in a straight line, and the drug in the vial 2 when pressing the needle disk roller 20 against the skin. Drug delivery mechanism for delivery to the needle disk 26 of the needle disk roller 20.

In addition, the needle disk roller device 1 may further include a connecting ring 13 for a more reliable assembly between the viscoelastic connecting cap 12 and the roller guiding holder 14.

In this embodiment, the vial 2 stores the drug in the form of a common vial. This drug may be a variety of drugs that can assist in the needling procedure for puncturing multiple micropores in the skin. As mentioned above, the vial 2 has an annular jaw 2a projecting in the radial direction on the outer circumferential surface of the opening at the top of the bottleneck 2b while an extension 2c is provided below the bottom of the bottleneck 2b. Is formed.

The viscoelastic connecting cap 12, as part of the needle disk roller device 1, allows the needle disk roller device 1 to be reliably assembled to the vial 2. In addition, the viscoelastic connection cap 12 is configured to be detachably coupled to the vial 2 in a one-touch manner, while being configured to be detachably coupled to the roller guiding holder 14.

The viscoelastic connection cap 12 is a viscoelastic material that can increase the assemblability with the vial (2) and the assemblability with the roller guiding holder 14 and can increase the elastic expandability and shrinkage of the valve hole described in detail below. It is formed of silicon material. In addition, when the viscoelastic connection cap 12 is coupled to the upper end of the vial (2), the lower outer cylinder portion 120a having a circular inner circumference in close contact with the outer circumferential surface of the bottleneck (2b) of the vial (2), and the vial ( A lower inner cylinder portion 120b having a circular outer circumference inserted into the opening of 2) and in close contact with the inner circumferential surface of the bottleneck 2b of the vial 2, and an upper inner circumference of the lower outer cylinder portion 120a and the lower inner cylinder portion 120b. The lower end of the roller guiding holder 14 when coupled to the lower end of the roller guiding holder 14 and the plate-shaped ring portion 120c which is in close contact with the upper end of the bottleneck 2b 140) the upper outer cylinder portion 121 in close contact with the outer surface, and the upper inner cylinder portion 122 formed on the inner side of the upper outer cylinder portion 121 while having a concentric axis with the upper outer cylinder portion 121.

According to this embodiment, the lower inner cylinder portion 120b and the lower outer cylinder portion 120a have the same upper height, and the lower inner cylinder portion 120b extends downward longer than the lower outer cylinder portion 120a. In particular, the lower inner cylinder portion 120b extends further down the lower end of the bottleneck 2b and is in close contact with the lower portion of the bottleneck 2b and the expansion portion 2c positioned below the lower end of the bottleneck 2b. The lower inner cylinder portion 120b includes an annular protrusion 129 protruding in a radial direction at a lower end thereof. When the viscoelastic connection cap 12 is coupled to the vial 2, the annular projection 129 shrinks and deforms while passing through the bottleneck 2b of the vial 2, and when the insertion is completed, with restoration While covering the lower end of the bottleneck 2b, the bottle neck 2b is securely in close contact with the expansion part 2c while being caught by the expansion part 2c below the lower end of the bottleneck 2b.

When the viscoelastic connection cap 12 coupled to the roller guiding holder 14 which holds the needle disk roller 20 in a vertically movable direction, is coupled to the upper end of the vial 2, the viscoelastic connection cap 12 The annular protrusion 129 formed on the lower inner cylinder portion 120b of the bottle is elastically contracted while being inserted into the bottleneck 2b and then returned to its original state while passing through a lower end of the bottleneck 2b. When the annular protrusion 129 is restored to its original state, the viscoelastic connection cap 12 is firmly fixed to the vial 2 by the annular protrusion 129 having an outer diameter larger than the inner diameter of the bottleneck 2b. do.

In addition, the viscoelastic connection cap 12 includes an annular retaining cover 121a extending inwardly from the front end of the upper outer cylinder portion 121, and the annular retaining cover 121a is part of the viscoelastic connecting cap 12. The lower stepped portion 140 of the roller guiding holder 14 is elastically deformed to have the viscoelasticity fitted therein, while the lower stepped portion 140 is fitted in close contact with the upper surface of the lower stepped portion 140. The guiding holder 14 is firmly fixed to the viscoelastic connection cap 12 in a sealed state.

In addition, the viscoelastic connection cap 12 integrally includes a valve membrane 123 integrally formed inside the hollow of the upper inner cylinder portion 122. The valve membrane 123 has a valve hole 1232 in the center thereof, and allows the valve hole 1232 to be elastically expanded or contracted by an external force due to a characteristic of a viscoelastic material, particularly a silicon material. do. The valve membrane 123 having the valve hole 1232 constitutes a drug delivery mechanism together with the valve operating portion 23 provided in the needle disk roller 20, and the valve operating portion 23 includes the needle. As the disk roller 20 moves forward and backward, the disk roller 20 interacts with the valve membrane 123 to open and close the valve hole 1232.

The lower inner cylinder portion 120b of the viscoelastic connection cap 12 is formed with an outer diameter such that the entire outer circumference thereof can be tightly inserted into the bottleneck 2b of the vial 2. In addition, the lower inner cylinder portion 120b extends longer than the bottleneck 2b and is in close contact with the lower side expansion part 2c of the bottleneck 2b below the bottom of the bottleneck 2b.

Therefore, when the viscoelastic connection cap 12 is coupled to the vial (2), the lower inner cylinder portion (120b) is completely in close contact with the entire inner circumference of the bottleneck (2b) of the vial (2) to prevent drug leakage It acts as a seal.

3 to 5, the roller guiding holder 14 is a hollow cylindrical structure having an open top and a bottom, and in the state where the needle disc roller 20 is fitted inside its hollow, The needle disk roller 20 is held up and down or retractable. The roller guiding holder 14 has a pair of guide grooves 142 for guiding the up and down linear movement of the needle disk roller 20 to face each other on an inner circumferential surface thereof. The needle guiding holder 14 has an upper stop portion 143 formed to prevent the needle guide roller 20 from detaching from the front end of the guide groove 142.

In addition, the needle disk roller 20, which is maintained in the roller guiding holder 14 to be able to move up and down linearly, and the roller bracket 22 is installed to be able to move up and down linearly along the guide groove 142 and Restrained by both the core rotating shaft 21 rotatably installed with respect to the roller bracket 22, the roller bobbin 24 rotatably installed with respect to the core rotating shaft 21, and the roller bobbin 24. And a plurality of annular needle disks 26 and a plurality of annular spacers 28 which rotate together with the roller bobbin 24 about the core axis of rotation 21.

The roller bobbin 24 is provided at both ends of the hollow rotating shaft 241 and the hollow rotating shaft 241 rotatably installed on the outer circumferential surface of the core rotating shaft 21 so as to be rotatable with respect to the core rotating shaft 21. And a pair of bobbin covers 242a and 242b for preventing the separation of the disk-spacer set including the plurality of annular needle disks 26 and the plurality of annular spacers 28. In this case, at least one bobbin cover 242b of the pair of bobbin covers 242a and 242b may be hollow to facilitate assembly and further separation of the annular needle disks 26 and the annular spacers 28. It may be detachably assembled with respect to the rotation shaft 241.

In this manner, the plurality of annular needle disks 26 and the plurality of annular spacers 28, even when assembled in a separated state, are constrained by the hollow rotating shaft 241, and all of them can rotate integrally. As a means for restraining the annular needle disks 26 and the annular spacers 26, a key groove 2412 formed in a longitudinal direction on an outer circumferential surface of the hollow rotating shaft 241, and an inner circumferential surface of each of the needle disks 26, respectively. First keys 265 are formed and second keys 285 are formed on inner circumferential surfaces of the spacers 28.

Each of the plurality of needle disks 26 includes a plurality of toothed needles 262 at regular intervals along the outer circumference. In addition, a drug delivery groove 263 is formed between neighboring needles 262.

The pair of bobbin covers 242a and 242b include a first bobbin cover 242a integrated with the hollow shaft 241 and a second bobbin cover 242b assembled with the first bobbin cover 242a, and a second When the assembly of the bobbin cover 242b and the hollow shaft 241 is released, the annular needle disks 26 and the annular spacers 28 can be inserted into or removed from the outer circumferential surface of the hollow rotating shaft 241. The annular needle disks 26 and the annular spacers 28 are alternately arranged on the outer circumferential surface of the hollow rotating shaft 241, and the rectangular first keys 265 and the spacers are formed on the annular needle disks 26. By fitting the second rectangular keys 285 formed in the plurality of keys into the key grooves 2412 formed on the outer circumferential surface of the hollow rotating shaft 241, the annular needle disks 26 and the annular spacers 28 are arranged in the hollow rotating shaft 26. Can be rotated integrally. Although a problem occurs in some of the needle disks during the assembly of the needle disk roller, only the corresponding needle disk may be manufactured.

On the other hand, the roller bracket 22 includes a base portion 221 and a pair of

shaft mounting walls

222 and 222 facing each other while being formed perpendicular to both sides of the front surface of the base portion 221, A pair of

shaft mounting walls

222 and 222 are provided with

shaft holes

2224 and 2224 in which the core rotation shaft 21 is rotatably fitted. Each of the pair of shaft mounting walls 222 is slidably fitted into the guide groove 142 (see FIGS. 1 to 3) of the roller guiding holder 14 described above.

The lower surface of the base portion 221 is formed with a valve actuating portion 23 constituting a part of the drug delivery mechanism. The valve actuating part 23 is perpendicular to the base part 221 and extends from the center of the lower surface of the base part 221 to the rear of the rod part 231 and the outer peripheral surface of the rod part 231. The formed tapered pressing portion 232 is included. The rod part 231 is fitted in a sealed state without the formation of minute gaps in the circular valve hole 1232 formed in the aforementioned valve membrane 123 (see FIGS. 1 to 3), and the needle disc roller 20 Move up and down together as you move up and down. The tapered pressing portion 232 is formed in the middle of the rod portion 231, gradually from the lower end having the same diameter as the rod portion 231 toward the upper end having a diameter larger than the rod portion 231 diameter It has a shape that increases in diameter. When the rod part 231 is retracted and the tapered pressure part 232 presses the valve membrane 123, the valve hole 1232 formed in the valve membrane 123 is the tapered pressure part 232. Its size is expanded to correspond to its diameter buildup. On the other hand, in the outermost diameter of the tapered pressing portion 232, the drug passing through the groove so that the diameter of the tapered pressing portion 232 reaches the innermost portion, that is, the portion that meets the rod portion 231 ( 233) is formed. The drug passage cutting groove 233 allows the drug to pass while the tapered pressure portion 232 presses the valve hole 1232. If the tapered pressurization portion 232 does not have a drug passage incision groove 233, even if the tapered pressurization portion 232 pressurizes the valve membrane 123 to expand the valve hole 1232, the valve hole 123 may be used. The tapered pressurization portion 232 is not blocked to allow the passage of the drug, but in this embodiment, a portion of the expanded valve hole 1232 is connected to the drug passage incision groove 233 to allow the passage of the drug. do. The tapered pressing portion 232 has a pair of drug passing incision grooves 233 closest to the outer circumference of the needle disk-spacer set, wherein the pair of drug passage incision grooves 233 is a needle disk ( 26) is formed at positions opposite to each other so as to smoothly supply the drug in any of the clockwise and counterclockwise rotation. More specifically, the pair of drug passage incision grooves 233 is formed in a form of bisecting the tapered pressing portion 232 in parallel with the needle disk 26.

Figure 6 is a view for explaining the action of the drug delivery mechanism according to the present invention, referring to Figure 6 (a), in the state that the needle disk roller is not pressed against the skin, the rod portion 231 is a silicon material It is fitted in the valve hole 1232 formed in the valve membrane 123 in a sealed state to prevent the drug outflow from the vial (2). At this time, since there is no retraction of the rod portion 231 and the tapered pressurization portion 232 formed in the rod portion 231, the valve membrane 123 is not pressurized, and thus, the valve hole 1232 formed in the valve membrane 123. ) There is no elastic expansion.

When the needle disk roller is pressed against the skin, the rod portion 231 and the tapered pressing portion 232 retreat to deform and push the valve membrane 123 back as shown in Fig. 6B. At the same time, the valve hole 1232 is expanded. Since the tapered pressurization portion 232 is fitted into the valve hole 1232 while expanding the valve hole 1232, the valve hole 1232 is provided through the drug passage incision groove 233 formed in the tapered pressurization portion 232. As a result, the drug stored in the vial 2 is discharged from the vial 2 through the valve hole 1232 and the drug passing incision groove 233 to be supplied to the needle disk of the disc roller.

Claims

A needle disk roller device in which a liquid drug is stored and detachably coupled to a vial including a bottleneck having a constant inner diameter,

A viscoelastic connection cap detachably coupled to the vial to cover the top opening of the bottleneck;

A roller guiding holder coupled to an upper end of the viscoelastic connection cap;

A needle disk roller which is held in a linear movement with the roller guiding holder; And

A drug delivery mechanism for delivering the drug in the vial to the needle disk of the needle disk roller when the needle disk roller is pressed against the skin,

The viscoelastic connection cap, the lower outer cylinder portion is in close contact with the outer circumferential surface of the bottle when coupled to the upper end of the vial, the lower inner cylinder portion inserted into the opening of the vial bottle and in close contact with the inner circumferential surface of the bottle, the upper inner circumference of the lower outer cylinder portion And a plate-shaped ring portion which is in close contact with an upper end of the bottle neck while connecting the upper outer periphery of the lower inner cylinder part, wherein the lower inner cylinder part extends further down the bottom of the lower outer cylinder part and beyond the lower end of the bottleneck. Disk roller device.
The method of claim 1, wherein the lower inner cylinder portion has an annular projection projecting in the radial direction at the bottom, when the viscoelastic connecting cap is coupled to the vial, the annular projection is deformed while passing through the bottleneck, and then restored And a needle disc roller device that is in close contact with the extension below the bottleneck bottom of the bottleneck.
The viscoelastic connection cap of claim 2, wherein the viscoelastic connection cap is in contact with an outer surface of the lower stepped portion of the roller guiding holder, an upper inner cylinder portion formed inside the upper outer cylinder portion while having a concentric axis with the upper outer cylinder portion, and the upper outer cylinder portion. And an annular retaining cover extending inwardly to the upper side, wherein the annular retaining cover is elastically deformed to fit the lower step of the roller guiding holder inward while being in close contact with the upper surface of the lower step when the lower step is fitted. Needle disk roller device, characterized in that for fixing the roller guiding holder to the viscoelastic connection cap in a sealed state.
The method according to claim 3, wherein the viscoelastic connection cap integrally comprises a valve membrane formed with a valve hole in the hollow inner portion of the upper inner cylinder portion, the needle disk roller is installed so as to move up and down linearly along the guide groove formed in the roller guiding holder A roller bracket, a core rotating shaft rotatably installed with respect to the roller bracket, a roller bobbin rotatably installed with respect to the core rotating shaft, and a plurality of annular needle disks rotating with respect to the core rotating shaft together with the roller bobbin. Wherein the drug delivery mechanism includes a valve actuating portion for delivering drugs from the vial to the needle disc side in cooperation with the valve membrane, wherein the valve actuating portion is fitted with the needle disc roller in a state where it is fitted without gap in the valve hole. The rod part which moves up and down linearly integrally, and the said rod part A tapered press portion formed in the middle and gradually increasing in diameter from the lower end having the same diameter as the rod portion toward the upper end having a larger diameter than the rod portion, and the drug passing incision groove formed in the tapered press portion. And the tapered pressurizing portion presses the valve membrane, and the valve membrane is pushed by the tapered pressing portion to expand the valve hole, and the valve hole is cut by the tapered pressurizing portion. Needle disk roller device characterized in that the connection with the groove is opened.