CN108778396B - Microneedle roller device comprising viscoelastic connecting cover with bottle neck lower end clinging structure - Google Patents
Microneedle roller device comprising viscoelastic connecting cover with bottle neck lower end clinging structure Download PDFInfo
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- CN108778396B CN108778396B CN201780016670.4A CN201780016670A CN108778396B CN 108778396 B CN108778396 B CN 108778396B CN 201780016670 A CN201780016670 A CN 201780016670A CN 108778396 B CN108778396 B CN 108778396B
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- roller
- cylinder part
- vial
- microneedle
- neck
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0061—Methods for using microneedles
Abstract
The invention discloses a microneedle roller device which can be separately combined with a medicine bottle, wherein the medicine bottle stores liquid medicine and comprises a bottle neck with a certain inner diameter. The microneedle roller device includes: a viscoelastic coupling cap covering the upper opening of the neck of the bottle and detachably coupled to the vial; a roller guide jig coupled to an upper end of the viscoelastic coupling cap; a microneedle roller maintaining linear movement in the roller guide jig; and a drug delivery mechanism for delivering the drug in the vial to the needle blade of the microneedle roller when the microneedle roller pressurizes the skin, wherein the viscoelastic coupling cap is coupled to the upper end of the vial, and comprises: a lower outer cylinder part closely attached to the outer peripheral surface of the bottle neck; a lower inner tube part inserted into the opening part of the medicine bottle and closely attached to the inner peripheral surface of the bottle neck; and a plate-shaped ring part which is connected with the inner periphery of the upper end of the lower outer cylinder part and the outer periphery of the upper end of the lower inner cylinder part and is tightly attached to the upper end of the bottleneck, and the lower inner cylinder part extends downwards through the lower end of the lower outer cylinder part and the lower end of the bottleneck.
Description
Technical Field
The present invention relates to a microneedle roller device for forming fine pinholes in the skin using a microneedle roller and injecting a drug through the pinholes, and more particularly, to a microneedle roller device having a viscoelastic coupling cap closely attached to not only the upper end of the neck of a vial but also the lower end and the inner surface of the neck when the microneedle roller is in contact with the vial in a state of being coupled to the microneedle roller.
Background
Microneedle roller devices have previously been proposed. These conventional needle roller devices include a member covering an opening portion formed at the upper end of the medicine bottle, and the member has an elastically deformable incision portion. Therefore, when the vial is turned upside down, the cut portion is pressed by the weight of the ball preset near the cut portion so that the opening is opened only in one direction. However, this needle roller device uses a transportation method in which the medicine drops on the needle piece located far away, and it is difficult to transport the medicine with reliability to each needle, and it is difficult to control not only the deformation of the cut portion by the weight of the ball, but also the cut portion is permanently deformed with the increase of the lifetime, and the needle roller device can be put in a state of no longer usable.
In particular, the prior art is inconvenient to combine the microneedle roller and the medicine bottle. Further, the conventional device has a disadvantage in that assembly of an assembly including the microneedle roller requires bolt locking, engagement, or the like, and thus the assemblability is poor.
In view of the above, the inventors of the present invention propose a microneedle roller device detachably contacted to a vial by a viscoelastic coupling cap, the microneedle roller device including a lower inner cylindrical portion partially fitted into and closely attached to the inside of a neck of the vial and a lower outer cylindrical portion closely attached to the outside of the neck of the vial, and being contacted to the vial by a double structure, wherein the vial has an opening portion at an upper end of the neck.
Disclosure of Invention
(problems to be solved)
The microneedle roller device proposed by the present inventors comprises a hook portion elastically engaged with the upper end threshold of the neck of the vial at the lower end of the lower outer cylinder portion of the viscoelastic coupling cap. However, in such a viscoelastic coupling cap, the lower inner cylindrical portion is inserted only into the middle of the neck of the vial, and therefore, the lower inner cylindrical portion cannot be firmly and stably coupled to the vial, and the drug may leak through a fine gap between the lower inner cylindrical portion and the inner surface of the neck of the vial.
Accordingly, an object of the present invention is to provide a microneedle roller device, which can be brought into contact with a lower inner cylindrical portion of a viscoelastic coupling cap of a medicine bottle, extend to the lower end of the inside of the bottle neck, and can be brought into close contact with the lower end of the inside of the bottle neck, thereby ensuring stable and firm contact with the viscoelastic coupling cap and preventing leakage of an undesired medicine more strictly.
(means for solving the problems)
According to one aspect of the present invention, there is provided a microneedle roller device detachably coupled to a medicine bottle storing a liquid medicine and including a neck having a certain inner diameter. The microneedle roller device includes: a viscoelastic coupling cap covering the upper opening of the neck of the bottle and detachably coupled to the vial; a roller guide jig coupled to an upper end of the viscoelastic coupling cap; a microneedle roller maintaining linear movement in the roller guide jig; and a drug delivery mechanism for delivering the drug in the vial to the needle blade of the microneedle roller when the microneedle roller pressurizes the skin, wherein the viscoelastic coupling cap is coupled to the upper end of the vial, and comprises: a lower outer cylinder part closely attached to the outer peripheral surface of the bottle neck; a lower inner tube part inserted into the opening part of the medicine bottle and closely attached to the inner peripheral surface of the bottle neck; and a plate-shaped ring part which is connected with the inner periphery of the upper end of the lower outer cylinder part and the outer periphery of the upper end of the lower inner cylinder part and is tightly attached to the upper end of the bottleneck, and the lower inner cylinder part extends downwards through the lower end of the lower outer cylinder part and the lower end of the bottleneck.
According to one embodiment, the lower inner cylindrical portion has an annular projection projecting in a radial direction at a lower end thereof, and when the viscoelastic coupling cap is coupled to the vial, the annular projection passes through the inside of the neck of the vial and is shrunk and deformed, and then, as it is restored to its original shape, the annular projection is caught by and closely contacts an expanded portion of the neck of the vial below the lower end of the neck of the vial.
According to one embodiment, the viscoelastic coupling cover comprises: an upper outer cylinder part closely attached to the outer side surface of the lower sill of the roller guide jig; an upper inner cylinder part having a concentric axis with the upper outer cylinder part and formed inside the upper outer cylinder part; and an annular retaining cover extending to the inner side of the upper end of the upper outer cylinder part, wherein the annular retaining cover is used for embedding the lower end threshold of the roller guide clamp to the inner side so as to be elastically deformed, and the lower end threshold is tightly attached to the upper surface of the lower end threshold in an embedded state and is fixed on the viscoelastic connecting cover in a state of sealing the roller guide clamp.
According to one embodiment, the viscoelastic coupling cap integrally includes a valve membrane forming a valve hole in a hollow inside of the upper inner cylinder portion, and the microneedle roller includes: a roller bracket configured to move linearly up and down according to a guide groove formed in the roller guide jig; a core rotation shaft configured to rotate the roller bracket; a roller spool rotatably provided to the core rotation shaft; a plurality of annular needle blades rotating the core rotation shaft together with the roller bobbin, and the medicine transfer mechanism includes a valve operating part transferring the medicine from the medicine bottle to the needle blade side in cooperation with the valve film, the valve operating part including: a rod part which linearly moves up and down integrally with the microneedle roller in a state of being seamlessly inserted into the valve hole; a tapered pressing portion formed in the middle of the rod portion, the tapered pressing portion gradually increasing in diameter from a lower end having the same diameter as the rod portion to an upper end having a larger diameter than the rod portion; the valve hole is formed by the tapered pressurizing portion and the tapered pressurizing portion, and the valve hole is opened by being connected to the medicine through the slit groove when the valve film is pressed by the tapered pressurizing portion.
(effect of the invention)
The microneedle roller device has the advantages that the lower inner cylinder part of the viscoelastic connecting cover which is contacted with the microneedle roller of the medicine bottle is extended to the lower end in the bottle neck and can be tightly attached to the lower end in the bottle neck, so that the microneedle roller device not only can be stably and firmly contacted with the viscoelastic connecting cover, but also can strictly prevent unwanted medicine from leaking.
Other advantages and effects of the present invention will be understood from the following description of the embodiments.
Drawings
Fig. 1 is a front view illustrating a microneedle roller device incorporated in a medicine bottle according to one embodiment of the present invention.
Fig. 2 is an exploded enlarged sectional view illustrating a microneedle roller device according to an embodiment of the present invention.
Fig. 3 is an exploded sectional view illustrating a microneedle roller device according to an embodiment of the present invention.
Fig. 4 is a perspective view illustrating the microneedle roller.
Fig. 5 is an exploded perspective view illustrating the microneedle roller.
Fig. 6 is a view illustrating the action of the drug delivery mechanism of the microneedle roller device.
Detailed Description
Hereinafter, preferred embodiments of the present invention will be described in detail with reference to the accompanying drawings. The drawings and the description thereof are provided to assist those skilled in the art in understanding the present invention. Accordingly, the drawings and description are not to be construed as limiting the scope of the invention.
As shown in fig. 1 to 3, a microneedle roller device 1 according to one embodiment of the present invention is coupled to an upper end of a vial 2 containing a liquid drug. The medicine bottle 2 includes a vertical neck 2b having an opening at an upper end and having a constant inner diameter. An annular threshold 2a is formed at the upper end of the neck 2b to project radially outward, and an expansion part 2c having a larger inner diameter than the neck 2b is formed at the lower end of the neck 2 b. The expanding portion 2c connects the inner surface of the neck 2b and the inside of the main body of the vial 2.
Further, the microneedle roller device 1 includes: a viscoelastic coupling cap 12 coupled to the vial 2 so as to cover an upper opening of the vial; a roller guide jig 14 coupled to an upper end of the viscoelastic coupling cover 12; a microneedle roller 20 that can maintain vertical linear movement on the roller guide jig 14; and a drug delivery mechanism for delivering the drug in the drug bottle 2 to the needle sheet 26 of the microneedle roller 20 when the microneedle roller 20 pressurizes the skin.
Furthermore, the microneedle roller device 1 may further comprise a connection ring 13 for a more reliable assembly between the viscoelastic connection cap 12 and the roller guide clamp 14.
In the present embodiment, the medicine bottle 2 stores medicine as a general medicine bottle shape. The medicament may be a variety of medicaments that facilitate acupuncture that perforates the skin through a plurality of fine pores. As described above, the medicine bottle 2 has the annular sill 2a protruding in the radial direction on the outer peripheral surface of the opening at the upper end of the neck 2b, and the expanded portion 2c is formed below the lower end of the neck 2 b.
The viscoelastic coupling cap 12 is a part of the microneedle roller device 1 and can be assembled in a sealed state, so that the microneedle roller device 1 has reliability with respect to the vial 2. Further, the viscoelastic coupling cap 12 is detachably coupled to the vial 2 by a one-touch manner and also detachably coupled to the roller guide jig 14.
The viscoelastic coupling cap 12 is formed of a silicon material of a viscoelastic material that can improve the elastic expandability and contractibility of the valve hole, which will be described in detail below, and can improve the assemblability with the vial 2 and the assemblability with the roller guide jig 14. The viscoelastic coupling cap 12 includes a lower outer tube portion 120a having a circular inner periphery and closely attached to the outer peripheral surface of the neck 2b of the vial 2 when coupled to the upper end of the vial 2; a lower inner tube part 120b having a circular outer periphery and inserted into the opening of the medicine bottle 2 and closely attached to the inner peripheral surface of the neck 2b of the medicine bottle 2; a plate-shaped ring portion 120c which connects an upper end inner circumference of the lower outer tube portion 120a and an upper end outer circumference of the lower inner tube portion 120b and is closely attached to an upper end of the bottle neck 2 b; an upper outer cylinder part 121 closely attached to an outer surface of the lower sill 140 of the roller guide jig 14 when coupled to the lower end of the roller guide jig 14; an upper inner cylinder part 122 coaxially with the upper outer cylinder part 121 and formed inside the upper outer cylinder part 121.
According to the present embodiment, the lower inner tube portion 120b and the lower outer tube portion 120a have the same upper end height, and the lower inner tube portion 120b is longer and longer in downward extension than the lower outer tube portion 120 a. In particular, the lower inner cylindrical portion 120b extends downward beyond the lower end of the neck 2b, and is in close contact with the lower end of the neck 2b and the expanded portion 2c located below the lower end of the neck 2 b. The lower inner tube portion 120b has an annular projection 129 projecting in the radial direction at the lower end. When the viscoelastic coupling cap 12 is coupled to the medicine bottle 2, the annular projection 129 passes through the inside of the neck 2b of the medicine bottle 2 and is shrunk and deformed, and then, when the insertion is completed, the lower end of the neck 2b is covered and caught by the expanded portion 2c on the lower side of the lower end of the neck 2b, and the annular projection is strongly adhered to the expanded portion 2 c.
When the visco-elastic connection cap 12 coupled to the roller guide jig 14 capable of maintaining the vertical linear movement of the microneedle roller 20 is coupled to the upper end of the vial 2, the annular protrusion 129 formed in the lower inner cylindrical portion 120b of the visco-elastic connection cap 12 is inserted into the neck 2b and elastically contracted, and then passes through the lower end of the neck 2b and is restored to its original state. When the annular projection 129 is restored to its original state, the viscoelastic coupling cap 12 is firmly fixed to the vial 2 by the annular projection 129 having an outer diameter larger than the inner diameter of the neck 2 b.
The viscoelastic coupling cover 12 includes an annular retaining cover 121a extending inward from the front end of the outer tube portion 121, and the annular retaining cover 121a has viscoelasticity as a part of the viscoelastic coupling cover 12, elastically deforms the lower end sill 140 of the roller guide jig 14 by fitting inward, and is tightly attached to the upper surface of the lower end sill 140 in a state where the lower end sill 140 is fitted, thereby firmly fixing the roller guide jig 14 to the viscoelastic coupling cover 12 in a sealed state.
Further, the viscoelastic coupling cap 12 integrally includes a valve film 123 integrally molded inside the center hole of the upper inner tube portion 122. The valve membrane 123 has a valve hole 1232 at the center, allowing the valve hole 1232 to be elastically expanded or contracted by an external force due to the characteristics of a viscoelastic material, particularly, a silicon material. The valve film 123 formed in the valve hole 1232 constitutes one drug transfer mechanism together with the valve operation part 23 provided in the microneedle roller 20, but the valve operation part 23 interacts with the valve film 123 as the microneedle roller 20 moves forward and backward, thereby opening and closing the valve hole 1232.
The lower inner tube portion 120b of the viscoelastic coupling cap 12 is formed to be closely inserted into the neck 2b of the vial 2 over the entire outer circumference. The lower inner tube portion 120b is extended to a length longer than the neck 2b, and strongly contacts the lower end side expanded portion 2c of the neck 2b below the lower end of the neck 2 b.
Therefore, when the viscoelastic coupling cap 12 is coupled to the vial 2, the lower inner tube portion 120b is completely in close contact with the entire inner peripheral surface of the neck 2b of the vial 2, thereby performing a sealing function for preventing leakage of the drug.
As shown in fig. 3 to 5, the roller guide jig 14 has a hollow cylindrical structure with upper and lower portions opened, and can maintain the microneedle roller 20 moving forward and backward in the vertical direction in a state where the microneedle roller 20 is fitted into the hollow of the roller guide jig. The roller guide jig 14 includes a pair of guide grooves 142 on an inner circumferential surface thereof, which face each other and guide the microneedle roller 20 to move linearly up and down. The roller guide jig 14 includes an upper end stop portion 143 formed at the front end of the guide groove 142 to prevent the microneedle roller 20 from coming off.
Further, the microneedle roller 20 includes, as the roller guide jig 14 capable of maintaining the up-and-down linear motion: a roller bracket 22 provided to be linearly movable up and down according to the guide groove 142; a core rotation shaft 21 provided to be rotatable with respect to the roller holder 22; a roller bobbin 24 provided to be rotatable with respect to the core rotary shaft 21; a plurality of annular pins 26 and a plurality of annular spacers 28 are constrained to rotate the core rotary shaft 21 between the roller spool 24 and the roller spool 24.
The roller spool 24 includes: a center hole rotary shaft 241 rotatably provided to the core rotary shaft 21 and rotatably provided on an outer peripheral surface of the core rotary shaft 21; a pair of shaft covers 242a, 242b disposed at both ends of the central hole rotation shaft 241 to prevent the needle piece-spacer set including the plurality of annular needle pieces 26 and the plurality of annular spacers 28 from falling off. At this time, at least one bobbin cover 242b of the pair of bobbin covers 242a, 242b can be assembled to the annular needle piece 26 and the annular spacer 28 for further separation, and the central hole rotating shaft 241 can be detachably assembled.
As described above, even when the annular needle pieces 26 and the annular spacers 28 are assembled in a separated state, they are constrained to the central hole rotation shaft 241 and can all rotate integrally. The means for restraining the annular needle piece 26 and the annular gasket 26 include: a key groove 2412 formed along the longitudinal direction on the outer peripheral surface of the center hole rotation shaft 241; first keys 265 formed on respective inner circumferential surfaces of the needle pieces 26; and a second key 285 formed on an inner circumferential surface of the spacer 28.
The plurality of needle pieces 26 are provided with a plurality of zigzag needles 262 at regular intervals along the outer periphery thereof. And, a drug transfer groove 263 is formed between the adjacent needles 262.
The pair of bobbin covers 242a and 242b includes a first bobbin cover 242a integrated with the middle hole bobbin 241 and a second bobbin cover 242b assembled with the first bobbin cover 242a, and when the second bobbin cover 242b and the middle hole bobbin 241 are disassembled, the annular needle piece 26 and the annular gasket 28 can be inserted into or separated from the outer peripheral surface of the middle hole bobbin 241. The annular needle pieces 26 and the annular spacers 28 are alternately fitted into the outer peripheral surface of the hollow rotary shaft 241, the rectangular first keys 265 formed on the annular needle pieces 26 and the rectangular second keys 285 formed on the spacers 28 are fitted into the key grooves 2412 formed on the outer peripheral surface of the hollow rotary shaft 241 in a row, and the annular needle pieces 26 and the annular spacers 28 are integrally rotated while being constrained to the hollow rotary shaft 26. In the assembling process of the microneedle roller, even if a problem occurs in a part of the plurality of needle sheets, the microneedle can be manufactured by replacing only the corresponding needle sheet.
In one aspect, the roller bracket 22 includes: a base portion 221; and a pair of shaft mounting walls 222, 222 vertically formed on both sides of the front surface of the base part 221 and facing each other, and shaft holes 2224, 2224 into which the core rotary shaft 21 is rotatably fitted are formed in the pair of shaft mounting walls 222, 222. The pair of shaft mounting walls 222 are slidably fitted into the guide grooves 142 of the roller guide jig 14 (see fig. 1 to 3).
A valve operating portion 23 constituting a part of the drug delivery mechanism is formed on a lower surface of the base portion 221. The valve operating portion 23 includes: a rod 231 which is perpendicular to the base 221 and extends rearward long from the center of the lower surface of the base 221; and a tapered pressing portion 232 formed on an outer circumferential surface of the rod portion 231. The rod 231 is fitted into a circular valve hole 1232 formed in the valve membrane 123 (see fig. 1 to 3) in a sealed state without a fine gap, and moves up and down together with the microneedle roller 20 according to the up and down movement. The tapered pressing portion 232 is formed in the middle of the rod 231, and has a shape in which a diameter thereof gradually increases from a lower end having the same diameter as the rod 231 to an upper end having a larger diameter than the rod 231. When the rod 231 is retracted and the tapered pressing portion 232 presses the valve film 123, the valve hole 1232 formed in the valve film 123 increases the diameter of the tapered pressing portion 232 and accordingly expands its size. On the other hand, the medicine passage cut groove 233 is formed from the outer frame of the tapered pressing portion 232 having the largest diameter to the inner side portion of the tapered pressing portion 232 having the smallest diameter, that is, to the portion contacting the rod portion 231. The medicine passage groove 233 allows the passage of the medicine during the time when the cone-shaped pressurizing part 232 pressurizes the valve hole 1232. When the tapered pressurizing portion 232 does not have the medicine passage slit 233, even if the tapered pressurizing portion 232 pressurizes the valve membrane 123 to expand the valve hole 1232, the valve hole 123 is blocked by the tapered pressurizing portion 232 and thus the medicine is not allowed to pass through, but in the present embodiment, a part of the area of the expanded valve hole 1232 is connected to the medicine passage slit 233, and thus the medicine is allowed to pass through. The tapered pressurizing portion 232 has a pair of medicine passage cutout grooves 233 which are most adjacent to each other at the outer circumference of the needle-chip-pad set, and the pair of medicine passage cutout grooves 233 are formed at positions facing each other so that the medicine can be smoothly supplied by rotating the needle chip 26 in any one of the clockwise direction and the counterclockwise direction. More specifically, the pair of drug passage incision grooves 233 are formed in a form of bisecting the tapered pressing portion 232 in parallel with the needle piece 26.
Fig. 6 is a view illustrating the operation of the drug delivery mechanism of the microneedle roller device, and referring to a of fig. 6, the stem 231 is inserted into the valve hole 1232 formed in the silicon valve film 123 in a sealed state to block the drug from flowing out of the vial 2 in a state where the microneedle roller is not pressed against the skin. At this time, since the rod 231 and the tapered pressing portion 232 formed in the rod 231 are not retracted, the valve film 123 is not pressed, and thus the valve hole 1232 formed in the valve film 123 is not elastically expanded.
When the microneedle roller is pressed against the skin and is operated, the rod 231 and the tapered pressing portion 232 move backward together as shown in fig. 6 b, and the valve hole 1232 is expanded while pushing the valve film 123 backward to deform it. Since the tapered pressurization portion 232 is fitted into the valve hole 1232 while expanding the valve hole 1232, the valve hole 1232 is opened by the drug passage slit groove 233 formed in the tapered pressurization portion 232, and thus the drug stored in the vial 2 passes through the valve hole 1232 and the drug passage slit groove 233, and is supplied from the vial 2 to the needle piece of the microneedle roller.
Claims (3)
1. A microneedle roller device separably incorporated in a medicine bottle storing a liquid medicine, and including a neck having a certain inner diameter, comprising:
a viscoelastic coupling cap covering the upper opening of the neck of the bottle and detachably coupled to the vial;
a roller guide jig coupled to an upper end of the viscoelastic coupling cap, the roller guide jig having a pair of guide grooves on an inner circumferential surface thereof;
a microneedle roller which is guided by the pair of guide grooves and keeps moving linearly in the roller guide jig; and
a drug delivery mechanism that delivers the drug in the vial to the needle blade of the microneedle roller when the microneedle roller pressurizes the skin, wherein,
the viscoelastic coupling cap, when coupled to the vial upper end, comprises:
a lower outer cylinder part closely attached to the outer peripheral surface of the bottle neck;
a lower inner tube part inserted into the opening part of the medicine bottle and closely attached to the inner peripheral surface of the bottle neck;
a plate-shaped ring part which is closely attached to the upper end of the bottle neck while connecting the upper end inner periphery of the lower outer cylinder part and the upper end outer periphery of the lower inner cylinder part
The lower inner cylinder part passes through the lower end of the lower outer cylinder part and the lower end of the bottle neck and is extended downwards;
the viscoelastic coupling cover further comprises:
an upper outer cylinder part closely attached to the outer side surface of the lower sill of the roller guide jig;
an upper inner cylinder part having a concentric axis with the upper outer cylinder part and formed inside the upper outer cylinder part;
an annular maintaining cover extending to the inner side of the upper end of the upper outer cylinder part and
the annular maintaining cover is elastically deformed so that a lower sill of the roller guide jig is inwardly embedded, and is closely attached to an upper surface of the lower sill in an embedded state, and is fixed to the viscoelastic connecting cover in a state of sealing the roller guide jig;
the viscoelastic coupling cover integrally includes a valve membrane forming a valve hole in the hollow inner side of the upper inner cylinder portion.
2. The microneedle roller device according to claim 1,
the lower inner cylinder part has an annular protrusion protruding in a radial direction at a lower end thereof, and when the viscoelastic coupling cap is coupled to the vial, the annular protrusion passes through the inside of the bottleneck and contracts and deforms, and then, the annular protrusion is hooked on an expansion part of the bottleneck below the lower end of the bottleneck and is tightly attached to the expansion part.
3. The microneedle roller device according to claim 1,
the microneedle roller includes:
a roller bracket configured to move linearly up and down along the pair of guide grooves;
a core rotation shaft configured to rotate the roller bracket;
a roller spool configured to rotate the core rotation shaft;
a plurality of ring-shaped needle blades rotating the core rotation shaft together with the roller bobbin, and
the drug delivery mechanism includes a valve operating portion that delivers the drug from the vial to the needle sheet side in cooperation with the valve membrane,
the valve operating portion includes:
a rod part which linearly moves up and down integrally with the microneedle roller in a state of being seamlessly inserted into the valve hole;
a tapered pressing portion formed in the middle of the rod portion, the tapered pressing portion gradually increasing in diameter from a lower end having the same diameter as the rod portion to an upper end having a larger diameter than the rod portion;
the medicine is formed on the cone-shaped pressurizing part through the cutting groove, and
when the valve membrane is pressurized by the cone-shaped pressurizing part, the valve membrane is pressed by the cone-shaped pressurizing part, so that the valve hole is expanded, and the valve hole is connected with the medicine through the cutting groove and is opened under the state of being expanded by the cone-shaped pressurizing part.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020160147838A KR101695603B1 (en) | 2016-11-08 | 2016-11-08 | needle disc roller apparatus comprising viscoelastic connection cap with structures being tightly joined to lower end of a bottle neck |
| KR10-2016-0147838 | 2016-11-08 | ||
| PCT/KR2017/008228 WO2018088676A1 (en) | 2016-11-08 | 2017-07-31 | Needle disk roller device comprising viscoelastic connection cap structured to be forced against lower end of bottleneck |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN108778396A CN108778396A (en) | 2018-11-09 |
| CN108778396B true CN108778396B (en) | 2020-12-01 |
Family
ID=57811609
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201780016670.4A Active CN108778396B (en) | 2016-11-08 | 2017-07-31 | Microneedle roller device comprising viscoelastic connecting cover with bottle neck lower end clinging structure |
Country Status (3)
| Country | Link |
|---|---|
| KR (1) | KR101695603B1 (en) |
| CN (1) | CN108778396B (en) |
| WO (1) | WO2018088676A1 (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101695603B1 (en) * | 2016-11-08 | 2017-01-12 | 이창우 | needle disc roller apparatus comprising viscoelastic connection cap with structures being tightly joined to lower end of a bottle neck |
| KR101993706B1 (en) * | 2017-06-13 | 2019-06-28 | 기 수 한 | Stamp type apparatus for injecting fluid |
| KR102006937B1 (en) * | 2017-09-29 | 2019-08-02 | 이승준 | Injection device |
| KR101865668B1 (en) * | 2018-02-06 | 2018-06-08 | (주)파비스트 | Needle disk roller apparatus for skin beauty care |
| CN109529182A (en) * | 2018-11-22 | 2019-03-29 | 广州美谛医药生物科技有限公司 | A kind of feedway and its beauty method of beautifying liquid |
| CN110354381A (en) * | 2019-06-17 | 2019-10-22 | 广东国源国药制药有限公司 | Microneedle device |
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Also Published As
| Publication number | Publication date |
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| KR101695603B1 (en) | 2017-01-12 |
| WO2018088676A1 (en) | 2018-05-17 |
| CN108778396A (en) | 2018-11-09 |
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