WO2018087665A1 - Microscope à champ clair vertical portable avec compatibilité de dispositif intelligent - Google Patents

Microscope à champ clair vertical portable avec compatibilité de dispositif intelligent Download PDF

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Publication number
WO2018087665A1
WO2018087665A1 PCT/IB2017/056974 IB2017056974W WO2018087665A1 WO 2018087665 A1 WO2018087665 A1 WO 2018087665A1 IB 2017056974 W IB2017056974 W IB 2017056974W WO 2018087665 A1 WO2018087665 A1 WO 2018087665A1
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WO
WIPO (PCT)
Prior art keywords
microscope
smart device
sample
lens
holder
Prior art date
Application number
PCT/IB2017/056974
Other languages
English (en)
Inventor
Samrat SINGH
Dipendra Singh BHADAURIYA
Sathyamoorthy G.
Binil JACOB
Alsaad Liqayat LAMBE
Greeshma UNNIKRISHNAN
Mahesh Kumar RATHOR
Eesha PUSALKAR
Original Assignee
Singh Samrat
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Singh Samrat filed Critical Singh Samrat
Publication of WO2018087665A1 publication Critical patent/WO2018087665A1/fr

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Classifications

    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/36—Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements
    • G02B21/365—Control or image processing arrangements for digital or video microscopes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N29/00—Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/24—Base structure
    • G02B21/241—Devices for focusing

Definitions

  • the present disclosure described herein in general, relates to optical elements, optical systems and optical apparatus, and particularly to microscopes and more particularly to portable upright microscopes with smart phone compatibility that are suitable for but not limited to use in medical, educational, agricultural and environmental sectors for capturing, transmitting and displaying magnified images of a sample to be examined.
  • the microscopic analysis samples on the field is critical to observe microorganisms in their natural environment or to detect infections in plants and to examine the health of saplings, to observe seeds, mites, nematodes, insects, plant cross sections.
  • the use of bulky, bench-top and expensive microscopes causes hindrance in this task since they are not compact and robust enough to survive the frequent transportations and rough handling endured during field use and often result in misalignment of the optics if not handled carefully.
  • Microscopes are an important learning tool for education, however their scarcity often compels many students to share a single microscope with the effect that it is difficult to ensure that the student is observing the required sample area as only one person can observe at a time.
  • some microscope designs permit coupling of the microscope to an image processor like a computer for better viewing of the sample object.
  • These microscopes are designed for observation of microscopic sample by looking through the eyepiece and require additional accessories such as a camera mount and a computer to observe, process, store and transmit captured images the sample on a screen. This increases the cost of equipment and space required and makes the process cumbersome. There is thus a need for a low cost, portable, high magnification microscope that also has processing power to facilitate transmission and image processing directly.
  • the utility model of an upright bright field microscope is described herein under, which is portable and allows display of the magnified image of a microscopic sample directly onto a handheld smart device such as a mobile phone or tablet to allow direct capturing, saving, transferring, processing and analysis of a digital image of the sample.
  • the utility model described herein under also has an innovative optical assembly and illumination assembly coupled with a unique focussing mechanism and X-Y movement assembly permitting accurate viewing of the image which can be magnified up to 1500 X.
  • a dedicated handset with a small attachment of lenses for magnification is disclosed.
  • the height of the objective lens from the sample can be adjusted through a three screw arrangement.
  • focusing is achieved by movement of the sample stage using a screw and bell crank lever mechanism coupled to a Z stage mechanism. Simple rotation of a knob is sufficient to vary the distance between the sample and the objective lens.
  • the arrangement used to mount the smartphone to microscope is disclosed.
  • the invention is restricted to a specific intervention whereas the present invention is broad-based.
  • the focussing mechanism and X-Y movement are also not disclosed in the prior art.
  • a technique for taking a picture of an image observed under a microscope by means of a film camera, a digital camera, a camera function of a portable phone, or the like has been developed.
  • Various adapters and attachments to be provided in the microscope to capture an image observed under a microscope with a film camera, a digital camera, or a camera function of a portable phone have been proposed.
  • the present invention discloses an upright bright field microscope herein under, which is portable and allows display of the magnified image of a microscopic sample directly onto a handheld smart device such as a mobile phone or tablet to allow direct capturing, saving, transferring, processing and analysis of a digital image of the sample for use in medical, agricultural, environmental and educational sectors, attempts to address the technical problems identified in the preceding paragraphs and to solve the long-standing need
  • an upright, movable bright-field microscope having provision for smart device compatibility.
  • the microscope may comprise of: a uniquely designed, path- length maintained, optical assembly for capturing, transmitting and displaying magnified images of a sample to be examined under the microscope.
  • the said optical assembly may comprise of an objective lens for capturing light from the illuminated sample and focusing the said light to produce a magnified image.
  • the optical assembly may further comprise an enclosed, novel, bent optical tube comprising of two mirrors or one prism and one mirror for transmission of the captured magnified image of the sample onto a lens stack, wherein said lens further magnifies the magnified image produced by the said one or more objective lens and projects onto the camera of a smart device.
  • an upright, movable bright-field microscope having provision for smart device compatibility.
  • the said microscope may comprise of a uniquely designed sample movement mechanism and sample focusing mechanism for enabling linear movement of a sample stage along three dimensions to enable accurate focusing and viewing of sample and wherein such unique design makes the said microscope compact and portable.
  • an upright, movable bright-field microscope having provision for smart device compatibility.
  • the said microscope may comprise of an illumination system to uniformly illuminate said sample on the sample stage.
  • the illumination system may comprise of a battery or an external power adapter run artificial light source wherein said light source may comprise a Light emitting diode (LED).
  • the illuminations system may further comprise of a casing for protection of the said battery run artificial light source.
  • the illumination system may further comprise of A first lens that is rounded, curving outward and placed just above the artificial light source.
  • the illumination system may further comprise of a blur filter and a second lens having one spherical surface and one flat surface above the blur filter and wherein, said illumination system is designed in a manner to maintain the compactness of the said microscope.
  • an upright, movable bright- field microscope having provision for smart device compatibility.
  • the microscope may comprise a holder for placing the said compatible smart device wherein such a holder is attached to the optical assembly of the said microscope.
  • the said holder may be so designed to maintain the required distance between the camera of the said smart device and the said lens stack for the magnified image to be displayed on the screen in focus and with maximum display size.
  • Figure 1 represents the complete innovation, namely a compact, portable upright bright field microscope with smart device compatibility (100).
  • Figure 1A represents the microscope (100) with smart device holder (104) aligned horizontally and figure IB represents the microscope
  • FIG. 101 represented in Figure 2A, 2B and 2C respectively.
  • Each figure represents the objective lens (201), the first mirror (202), a second mirror / prism (203), a lens stack (204) and the holder for the smart device (104).
  • FIG. 102 [ ⁇ 21] Figure 3 represents in detail the various components of the said illumination assembly (102).
  • the various components include an artificial light source (302), a casing for the said artificial light source (301), a first lens (303), a blur filter (304) and a second lens (305); all components arranged to ensure uniform illumination of the sample under observation in the said microscope (100)
  • Figure 4 represents in detail the X-Y movement mechanism and the Z-stage focussing system (103).
  • the various components of the said X-Y movement mechanism and Z-stage focussing system include a Y knob (401), Y plate (402), a Y pillar (403), a X-Y connector (404), X knob (405), X plate (406), sample slide (407), finely threaded screw (408), a moving nut (409), a guiding pin (410), a bell crank lever (411), Z-stage (412), a focussing knob (413), a sample stage (414), a base plate (415) and illumination system (102).
  • the invention relates to optical illumination techniques that use a combination of lenses to magnify images of small samples and further employ handheld devices with display screens to project magnified images of the sample on to the display screen. More specifically, the invention relates to the use of an upright bright-field microscope with a holder for a handheld smart device to project, record, transmit and save data onto the smart device.
  • the optical assembly may comprise of an objective lens (201) comprising one or more lenses of varying powers made from glass housed in cylindrical casing which gather light from the object being observed.
  • the said light from the objective lens produces a magnified real image of the object being observed which is further magnified by the said optical tube (not shown in figure) and reflected onto the camera of said smart device held within a smart device holder.
  • the said optical assembly may comprise a single objective lens with fixed magnification.
  • the optical assembly may comprise a rotatory nosepiece with multiple objective lenses with provision for variable magnification.
  • the said optical assembly may comprise single objective lens in case of fixed magnification or a rotatory nosepiece with multiple objective lenses in case of variable magnification or a combination of both.
  • the optical assembly may comprise of the said optical tube (not shown in figure) wherein, the shape of the optical tube is designed in a way such that light travelling within the optical tube from the said objective lens is bent at certain angles along the path of the tube which may enable the microscope to be compact and portable.
  • the optical assembly may comprise of the said optical tube comprising of at least one of the combinations of prisms and mirrors and a lens stack.
  • the said optical tube (not shown in figure) comprises at least one of the combinations comprising of a first mirror (202, not shown separately in figure), a second mirror or prism (203, not shown separately in figure) and a lens stack (204, not shown separately in figure).
  • the said lens stack (204) may be composed of at least one of the combinations of double convex and concave-convex lenses that further magnifies the magnified image produced by the objective lenses and projects it onto the camera of the said smart device or an independent camera module.
  • FIG 2A, Figure 2B and Figure 2C some combinations of the above mentioned elements of the optical tube have been illustrated in Figures 2A, Figure 2B and Figure 2C respectively. It is to be noted that the said combinations are mere illustrations and do not confine or restrict the scope of the inventions to the said combinations.
  • the optical assembly may comprise of the said optical tube wherein the said optical tube may comprise two plane mirrors, mirror 1 (202a) and mirror 2 (203a), to bend the light from the objective lenses. Both the mirrors may be aligned in such a way to bend the light at identical angles.
  • the light reflected from the said second mirror (203a) may emerge perpendicular to the base, and may pass through the said lens stack (204a) composed of double convex and concave-convex lenses and the said reflected light may be projected onto the camera of the said smart device or said independent camera module placed parallel to the base.
  • the optical assembly may comprise of the said optical tube wherein said optical tube may comprise of two plane mirrors, mirror 1 (202b) and mirror 2 (203b), to bend the light from the objective lenses.
  • the mirrors may be aligned in such a way to project the emerging light onto the camera of the said smart device or said independent camera module placed at an angle of 45 degree to the base, after passing through said lens stack (204b) composed of double convex and concave-convex lenses.
  • the alignment of the mirrors may be modified to change the viewing angle of the smart device.
  • the optical assembly may comprise of the said optical tube wherein said optical tube may comprise of one plane mirror (202c) and one right angle prism (203c) to bend the light from the objective lenses.
  • the alignment of the right- angle prism may be designed to bend light by 180 degree.
  • the mirror and prism may be aligned in such a way to project the emerging light onto the camera of the said smart device or said independent camera module placed at an angle of 45 degree to the base, after passing through the lens stack (204c).
  • the alignment of the mirror and prism may be modified to change the viewing angle of the smart device.
  • the optical assembly may comprise of the said optical tube wherein said optical tube may comprise of one right angle prism and one special prism with reflective coating on one surface capable of bending light from the objective lenses at 45 degree.
  • the alignment of the right-angle prism may be designed to bend said light by 180 degree.
  • the two prisms are aligned in such a way to project the emerging light onto the camera of the smart device or said independent camera module placed at an angle of 45 degree to the base after passing through the said lens stack.
  • the alignment of the prisms may be modified to change the viewing angle of the smart device.
  • the said illumination assembly (102) may comprise of a two-lead semiconductor light source (302) enclosed within a protective casing (301) wherein said light source may comprise a p-n junction diode which emits light when activated and wherein, more specifically the light source may comprise a light emitting diode (LED).
  • said light source may comprise a p-n junction diode which emits light when activated and wherein, more specifically the light source may comprise a light emitting diode (LED).
  • LED light emitting diode
  • the said illumination assembly (102) may comprise of a combination of lenses comprising a first lens (303) that is rounded, curving outward that may be placed just above said light source.
  • the said first lens may be separated from a second lens (305) having one spherical surface and one flat surface which may be placed above the first lens.
  • a wavelength filter or blur filter (304) can be used for separating the said first and second lenses wherein the said wavelength filter or blur filter may reflect, transmit or absorb different wavelength of light emitted from the said light source.
  • the said light source (302) enclosed within a protective casing (301), the said first lens (303), the said blur filter (304) and said second lens (305) may be stacked in close contact with each other to form the illumination assembly.
  • the said illumination assembly (102) may be designed to prevent uneven illumination and image distortions caused due to placing light source very close to the sample and may result in the light emerging from the assembly to illuminate the sample placed on the sample stage uniformly.
  • the illumination assembly (102) may be provided with light intensity regulator to regulate the intensity of the light falling on the sample slide and wherein the said light source may be replaced to change the incident wavelength as per the need of the user.
  • the said X-Y slide movement mechanism (103) may comprise of a combination of the X movement mechanism and the Y movement mechanism.
  • X-Y Moving mechanism may consist of two knobs X Knob (405) and Y Knob (401) that may help the user to move the sample slide (407) fixed on the slide holder which is on the sample stage (414) along the respective X axis and Y axis.
  • the sample holder may be attached to the X plate (406) and may possess a clamping system to hold the sample slide. The said movement may allow scanning of different areas of the specimen on the sample slide.
  • the Y movement mechanism may comprise of a Y pillar (403) attached to the sample stage (414), a Y plate (402) connected to the Y pillar, a Y knob (401), a rack and pinion system and a dovetail groove.
  • the Y movement mechanism may convert the rotatory motion of the Y knob to linear motion of the Y plate using the rack and pinion system which is a type of linear actuator that comprises a pair of gears which convert rotational motion into linear motion.
  • a circular gear called “the pinion” engages teeth on a linear "gear” bar called “the rack”; rotational motion applied to the pinion causes the rack to move relative to the pinion, thereby translating the rotational motion of the pinion into linear motion.
  • the dovetail groove may guide the movement of the Y plate and maintains the linearity.
  • a connector (404) may connect the Y plate (402) to the X mechanism.
  • the X mechanism may comprise of a X knob (405), a X plate (406), a worm gear mechanism and a dovetail groove.
  • the X movement mechanism may convert the rotatory motion of the X knob to linear motion of the X plate by the worm gear mechanism which may assist in movement of the sample along the X axis.
  • the dovetail groove may guide the movement of the X plate and help maintain the linearity.
  • micro-focussing of the sample may be achieved by employing the said Z-axis focussing mechanism.
  • focusing mechanism involves movement of the objective lens along the z axis, which affects the magnification achieved by the system, since magnification is dependent on the tube length.
  • the said Z mechanism for focussing may comprise of movement of the sample stage (414) along the Z-axis.
  • the Z mechanism may comprise of using a finely threaded screw (408), a moving nut (409) and a bell crank lever (411) mechanism coupled to the Z stage (412).
  • the Z mechanism may comprise of focusing of the magnified image by simple rotation of the knob to vary distance between the sample (407) and the objective lens (201).
  • the Z stage mechanism may comprise of movement of the sample stage (414) in the vertical direction and may permit very fine and very stable focusing of the magnified image.
  • the Z stage (412) may be composed of two parts, one of which is attached to the Z stage support (416) and the other to the sample stage.
  • a bell crank lever (411) may be attached to the first part of the Z stage which is attached to the Z stage support. Relative motion between the two parts of the Z stage may be achieved using ball bearings or cross roller guides.
  • the sample stage (414) may be held in the upward position using a spring. Rotational motion of the focusing knob may cause linear movement of the moving nut along the guiding pin (410), which in turn may push one hand of the bell crank lever, pushing the sample stage to be vertically displaced in the downward direction.
  • the Z stage support along with the Z stage (back) may be fixed to the base plate (415). Rotation of the focusing knob in the opposite direction may cause the sample stage to move upwards due to tension in the spring.
  • the said optical assembly (101) may be connected to said holder of smart device (104) with smart device compatibility features.
  • the design of the holder may align the camera of a smart device or an independent camera module to the optical assembly while securing the device firmly.
  • the camera of the said smart device may be aligned to the said optical assembly such that the light emerging from the said lens stack may be projected directly into the camera at an angle of 90 degrees, enabling the magnified image to be displayed on the screen of the smart device or an independent screen connected to the camera module.
  • the holder (104) may also maintain the exact distance required between the said camera of the said smart device and the said lens stack for the magnified image to be displayed on the screen in focus and with maximum display size.
  • the holder (104) may be designed with dimensions specific to certain smart devices such as mobile phones, tablets, etc. or in other cases, may be designed to be a universal design to fit all smart devices.
  • the holder may be kept detachable to allow interchangeable use of multiple smart devices.
  • the orientation of the holder may be designed to keep the smart device horizontal, or at an angle, depending upon the design of the optical tube.
  • the said microscope (100) provides for a range of magnification from 10X to 1500 X while permitting accurate focussing to enable viewing of highly magnified image.
  • the said LED illumination (302) is powered by a rechargeable/non- rechargeable battery that may make the device portable.
  • the illumination system may also work on direct AC power supply. Circuits for battery charging and LED intensity regulation may also be provided.
  • the disclosed microscope (100) is compact and extremely handy to enable researchers to use it for field studies of significance to the environmental and agricultural sector.
  • the disclosed microscope (100) is beneficial for education sector, permitting better access viewing of magnified sample to students.
  • the disclosed microscope is of use for medical professionals to seek expert help through remote diagnosis.

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  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Multimedia (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Microscoopes, Condenser (AREA)

Abstract

La présente invention concerne un modèle d'utilité plus particulièrement un microscope (100) comprenant un ensemble optique (101), un ensemble d'éclairage (102), un mécanisme pour le déplacement de l'étage d'échantillon le long des axes X-Y et une focalisation le long de l'axe Z (103), et un support (104) pour un dispositif électronique d'imagerie et de communication mobile. Ledit ensemble d'éclairage est conçu pour émettre de la lumière à partir d'une source de lumière de fonctionnement de batterie artificielle sur l'échantillon. Ledit ensemble optique est conçu pour comprendre une combinaison de miroirs, de granules et de lentille pour capturer et afficher des images microscopiques agrandies de l'échantillon à un grossissement allant jusqu'à 1500X. Ledit ensemble de focalisation comprend diverses vis, des leviers à écrous pour permettre le mouvement de la lame d'échantillon le long de trois dimensions pour une focalisation précise. Ledit support de dispositif intelligent est conçu pour aligner l'ouverture de caméra du support sur l'ensemble optique pour visualiser, traiter, transmettre et stocker directement des images microscopiques de l'échantillon.
PCT/IB2017/056974 2016-11-14 2017-11-08 Microscope à champ clair vertical portable avec compatibilité de dispositif intelligent WO2018087665A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN201621038757 2016-11-14
IN201621038757 2016-11-14

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WO2018087665A1 true WO2018087665A1 (fr) 2018-05-17

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020165941A1 (fr) * 2019-02-12 2020-08-20 株式会社 山忠 Dispositif microscopique
CN113589508A (zh) * 2021-08-19 2021-11-02 绍兴格物光学有限公司 一种基于便携式显微镜的图像采集方法
CN114035311A (zh) * 2021-11-23 2022-02-11 上海中珂光镊科技有限公司 一种光镊显微镜
US11249293B2 (en) 2018-01-12 2022-02-15 Iballistix, Inc. Systems, apparatus, and methods for dynamic forensic analysis

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130100271A1 (en) * 2011-10-21 2013-04-25 Transamerican Technologies International dba: TTI Medical Universal dual camera adapter

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130100271A1 (en) * 2011-10-21 2013-04-25 Transamerican Technologies International dba: TTI Medical Universal dual camera adapter

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11249293B2 (en) 2018-01-12 2022-02-15 Iballistix, Inc. Systems, apparatus, and methods for dynamic forensic analysis
WO2020165941A1 (fr) * 2019-02-12 2020-08-20 株式会社 山忠 Dispositif microscopique
JP6868750B2 (ja) * 2019-02-12 2021-05-12 株式会社山忠 顕微鏡装置
JPWO2020165941A1 (ja) * 2019-02-12 2021-05-20 株式会社山忠 顕微鏡装置
US11860355B2 (en) 2019-02-12 2024-01-02 Yamachu Co., Ltd. Microscopic device
CN113589508A (zh) * 2021-08-19 2021-11-02 绍兴格物光学有限公司 一种基于便携式显微镜的图像采集方法
CN114035311A (zh) * 2021-11-23 2022-02-11 上海中珂光镊科技有限公司 一种光镊显微镜

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