WO2018072665A1 - Brumisateur mutliperforé - Google Patents

Brumisateur mutliperforé Download PDF

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Publication number
WO2018072665A1
WO2018072665A1 PCT/CN2017/106286 CN2017106286W WO2018072665A1 WO 2018072665 A1 WO2018072665 A1 WO 2018072665A1 CN 2017106286 W CN2017106286 W CN 2017106286W WO 2018072665 A1 WO2018072665 A1 WO 2018072665A1
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WO
WIPO (PCT)
Prior art keywords
drug storage
cavity
bottle body
storage bottle
chamber
Prior art date
Application number
PCT/CN2017/106286
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English (en)
Chinese (zh)
Inventor
曹立
林洪涛
徐义全
黄芳芳
李建霖
Original Assignee
广东东阳光药业有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 广东东阳光药业有限公司 filed Critical 广东东阳光药业有限公司
Priority to CN201780006885.8A priority Critical patent/CN108463261A/zh
Publication of WO2018072665A1 publication Critical patent/WO2018072665A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes

Definitions

  • the invention relates to the technical field of medical instruments, and in particular to a multi-chamber atomization device.
  • the medical device includes a product which is an atomizer.
  • the atomizer is mainly used for treating various upper and lower respiratory diseases, such as cold, fever, cough, asthma, sore throat, pharyngitis, rhinitis, bronchitis, pneumoconiosis, etc. Diseases occurring in the bronchi, alveoli, and thoracic cavity.
  • Nebulized inhalation therapy is an important and effective treatment method for the treatment of respiratory diseases.
  • the nebulizer is used to atomize the liquid into tiny particles. The drug enters the respiratory tract and lungs by breathing inhalation, thereby achieving painlessness. The purpose of rapid and effective treatment.
  • the drug storage devices of the atomizer are single-chamber type, and in actual use, some drugs have poor stability, and the active ingredient of the drug needs to be separated from the solution during storage, and the drug is only used when used. Mix with the solution to ensure the best effect of the agent.
  • a drug storage device capable of separating a drug from a solution is not provided, and for a drug having poor stability, there is a risk of a decrease in efficacy or even failure.
  • the object of the present invention is to provide a multi-chamber atomization device which can effectively form a medicament before use.
  • the solution is separated from the solution and mixed only when it is used, thereby improving the effect of the agent.
  • a multi-chamber atomization device comprising a multi-chamber drug storage device for storing a medicament, the multi-chamber drug storage device comprising a drug storage bottle body, the inner cavity of the drug storage bottle body being provided with a spacer
  • the spacer divides the inner cavity of the drug storage bottle body into at least two cavityes, and the different cavityes are separated from each other before the drug is used. When the medicine is used, different the cavityes are mutually connected. Turn on.
  • the isolation function will be broken to make the different cavities conduct, so that the active ingredient of the medicament is separated from the solution before use, and the external pressure can be mixed when used.
  • the effect is to improve the effect of the medicament.
  • the number of the spacers and the cavity is arbitrarily selected and designed according to the kind of the drug.
  • the drug storage bottle body is made of a plastic deformation material
  • the separator includes a first sealing film, and the first sealing film is fixedly connected to an inner wall of the drug storage bottle body.
  • the first sealing film divides the inner cavity of the drug storage bottle body into a first cavity and a second cavity.
  • the first sealing film is a flexible sealing film, and the first sealing film is easily broken under external force. Specifically, an external force is applied to the sidewall of the drug storage bottle body to force deformation of the drug storage bottle body, thereby rupturing the first sealing film, and the first cavity and the second The cavity is turned on.
  • the first sealing film is disposed between the bottle mouth of the drug storage bottle body and the bottom of the bottle.
  • the spacer further includes a second sealing film, the second sealing film is located between the first sealing film and the bottom of the drug storage bottle body, the second sealing The membrane is fixedly attached to the inner wall of the reservoir body.
  • the first sealing film and the second sealing film divide the inner cavity of the drug storage bottle body into a first cavity, a second cavity and a third cavity.
  • the second sealing film is a flexible sealing film, and the second sealing film is easily broken under external force. Specifically, an external force is applied to the side wall of the drug storage bottle body to force deformation of the drug storage bottle body, thereby breaking the first sealing film and the second sealing film to make the first cavity
  • the second cavity is electrically connected to the third cavity.
  • the spacer further comprises a third sealing film, the third sealing film being located between the second sealing film and the bottom of the drug storage bottle body, the third sealing film and the storage
  • the inner wall of the vial body is fixedly connected, and the third sealing film is a flexible sealing film.
  • the first sealing film, the second sealing film and the third sealing film divide the inner cavity of the drug storage bottle body into a first cavity, a second cavity, a third cavity and a fourth cavity.
  • the number of sealing films and cavities can be selected according to the number of drugs to be mixed to satisfy the storage of a plurality of different drugs.
  • the drug storage bottle body is made of a rigid material
  • the separator comprises a first partition plate, and the first partition plate is slidably connected to an inner wall of the drug storage bottle body,
  • the inner cavity of the drug storage bottle body is outwardly extended with at least one first convex cavity, the width of the first convex cavity is larger than the thickness of the first partition, and the inner cavity of the drug storage bottle body
  • a rear partition plate is disposed on a side of the separating member away from the bottle mouth of the drug storage bottle body, the rear partition plate is slidably connected to an inner wall of the drug storage bottle body, and the thickness of the rear partition plate is The sum of the thicknesses of the first partitions is greater than the width of the first raised pockets.
  • the first partition partitions the inner cavity of the drug storage bottle body into a first cavity and a second cavity.
  • the first partition is located at a side of the first convex cavity away from the mouth of the drug storage bottle body.
  • an external force is applied to the rear partition to drive the rear partition to move toward the first partition, and when the medicament in the second chamber is compressed to a certain extent, the rear The baffle will drive the first baffle to move toward the first convex cavity by the compressed medicament until the first baffle reaches the position of the first convex cavity due to the a raised cavity
  • the width of the first partition is larger than the thickness of the first partition, so that the first convex cavity forms a conduction interval on both sides of the first partition, so that the first cavity and the second volume
  • the cavity is turned on, at which time the pressure in the second cavity is released, and the first spacer is not continuously driven to move, so that the first spacer stays at the position of the first convex cavity, thereby
  • the first cavity and the second cavity are kept in an on state, and finally the rear baffle is adhered to the first baffle, and an external force is
  • the multi-chamber drug storage device is gently shaken to uniformly mix the medicaments, and then the multi-chamber drug storage device is connected to the atomization device to perform atomization treatment.
  • the width of the first convex cavity refers to the dimension of the first convex cavity along the line connecting the mouth of the drug storage bottle body and the bottom of the bottle;
  • the thickness refers to the dimension of the first partition along the line connecting the mouth of the drug storage bottle body to the bottom of the bottle.
  • the spacer further includes a second partition, the second partition is located between the first partition and the rear partition, and the second partition is The inner wall of the drug storage bottle body is slidably connected, and the inner cavity of the drug storage bottle body is outwardly extended with at least one second convex cavity, and the width of the second convex cavity is larger than that of the second partition a thickness, the second convex cavity is located between the first convex cavity and the rear partition, and a sum of a thickness of the rear partition and a thickness of the second partition is greater than the first The width of the two raised pockets.
  • the first partition and the second partition divide the inner cavity of the drug storage bottle body into a first cavity, a second cavity and a third cavity.
  • the second partition is located on a side of the second convex cavity away from the mouth of the drug storage bottle body.
  • the width of the first convex cavity refers to the dimension of the first convex cavity along the line connecting the mouth of the drug storage bottle body and the bottom of the bottle;
  • the thickness refers to the dimension of the first partition along the line connecting the mouth of the drug storage bottle body to the bottom of the bottle.
  • the width of the first convex cavity is equal to the width of the second convex cavity
  • the thickness of the first partition is equal to the thickness of the second partition
  • a plurality of the first convex cavities are equally spaced along the circumferential direction of the drug storage bottle body, and all of the first convex cavity and the bottle mouth of the drug storage bottle body The distance between the two raised cavities is equally spaced along the circumferential direction of the drug storage bottle body, and all of the second convex cavity is between the bottle mouth of the drug storage bottle body The distance between the second convex cavity and the mouth of the drug storage bottle body is greater than the distance between the first convex cavity and the bottle mouth of the drug storage bottle body.
  • the number of the first convex cavities is 1 or 2 or 3 or 4 or 5 or 6 or 7 or 8 or 9 or 10.
  • the number of the second convex cavities is 1 or 2 or 3 or 4 or 5 or 6 or 7 or 8 or 9 or 10.
  • the number of the first convex cavity is equal to the number of the second convex cavity.
  • providing a plurality of the first convex cavity and the second convex cavity can increase a conduction area between different cavities, thereby improving mixing efficiency.
  • the invention further includes an atomizing sheet mounted on one end of the flow guiding joint, and an inclined flow channel on the guiding joint, the inclined flow channel Communicating with the atomizing sheet, the multi-chamber drug storage device is mounted on a side of the inclined flow path away from the atomizing sheet, and the inclined flow channel is adjacent to an end of the atomizing sheet One end of the multi-chamber drug storage device is tilted upward.
  • the total residual amount of the liquid medicine below the liquid level calibration line for the normal operation of the atomizing sheet comprises two parts, the first part is the residual amount in the inclined flow channel, and the second part is that the flow guiding joint is away from the liquid storage container The amount of residue in the mounting groove at one end.
  • the residual amount of the first portion decreases as the inclination angle of the inclined flow channel increases. Therefore, the solution connects the atomization sheet and the liquid storage container through the flow guiding joint, and opens the inclined flow channel on the flow guiding joint, and tilts
  • the designed inclined flow channel can reduce the liquid storage space below the normal working liquid level of the atomizing piece, effectively reducing the volume of the liquid medicine remaining in the atomizer which cannot be atomized, thereby reducing waste.
  • a horizontal flow channel may be formed on the flow guiding joint, the horizontal flow channel is in communication with the atomizing sheet, and the multi-chamber drug storage device is installed on the horizontal flow channel away from the atomizing sheet.
  • One side. The axis of the horizontal flow path is parallel to the horizontal plane.
  • the angle between the axial line of the inclined flow channel and the horizontal plane is 10 degrees or more and 70 degrees or less.
  • the angle between the axial line of the inclined flow channel and the horizontal plane is 15 degrees or more and 60 degrees or less.
  • the angle between the axis of the inclined flow channel and the horizontal plane is 10 degrees or 15 degrees or 20 degrees or 25 degrees or 30 degrees or 35 degrees or 40 degrees or 45 degrees or 50 degrees or 55 degrees or 60 degrees or 65 degrees or 70 degrees.
  • the shape of the port on the side of the inclined flow path adjacent to the atomizing sheet is elliptical, and in the case where the length of the long axis of the port on the side of the inclined flow path close to the atomizing sheet is fixed, As the inclination angle of the inclined flow path increases, the diameter of the inclined flow path will decrease. Due to the surface tension of the liquid, the liquid does not easily pass through a narrow space under the action of its own gravity, that is, the smaller the diameter of the inclined flow path, the more difficult the liquid medicine passes through the inclined flow path, and thus the diameter of the inclined flow path Can not be too small, so that the liquid can not pass smoothly. According to the above analysis, the inclination angle of the inclined flow channel cannot be too Large, otherwise it will cause the liquid medicine to pass through the inclined flow channel to cause insufficient supply of liquid medicine.
  • the inclined flow path is disposed at one end of the atomizing sheet from the container interface, and the bottle mouth position of the multi-chamber drug storage device is provided with a container joint, and the container joint is inserted in Inside the container interface.
  • the axis line of the container interface is on the same line as the axis line of the inclined flow channel;
  • the axis of the container interface is parallel to the horizontal plane
  • the axis of the container interface is perpendicular to the horizontal plane.
  • the multi-chamber drug storage device is detachably connected to the flow guiding joint.
  • a housing is further included, and the flow guiding joint is detachably connected to the housing.
  • the invention has the beneficial effects of providing a multi-chamber atomization device, which is divided into at least two cavities by providing a spacer in the inner cavity of the drug storage bottle body. After the spacer is subjected to external pressure, the isolation function will be broken and the different chambers will be turned on, so that the active ingredient of the medicament is separated from the solution before use, and the external pressure can be mixed during use to improve the medicament. The effect of the effect.
  • FIG. 1 is a schematic cross-sectional view of the multi-chamber drug storage device of the first embodiment
  • FIG. 2 is a schematic structural view of an atomizing device according to an embodiment
  • Figure 3 is an exploded view of the atomizing device of the embodiment
  • FIG. 5 is a cross-sectional view showing a flow guiding joint, a multi-chamber drug storage device, and a rectifying ring according to an embodiment
  • FIG. 6 is a cross-sectional view showing the multi-chamber drug storage device of the second embodiment
  • Figure 7 is a cross-sectional view showing a state of the multi-chamber drug storage device of the fourth embodiment
  • Figure 8 is a cross-sectional view showing another state of the multi-chamber drug storage device of the fourth embodiment.
  • Figure 9 is a cross-sectional view showing still another state of the multi-chamber drug storage device of the fourth embodiment.
  • Figure 10 is a cross-sectional view showing the multi-chamber drug storage device of the fifth embodiment.
  • FIG. 11 is a schematic structural view of an atomizing device according to Embodiment 8.
  • Figure 12 is a cross-sectional view showing the multi-chamber drug storage device of the eighth embodiment.
  • Multi-chamber storage device 1. Multi-chamber storage device
  • Embodiment 1 is a diagrammatic representation of Embodiment 1:
  • a multi-chamber atomization device includes a multi-chamber drug storage device 1.
  • the multi-chamber drug storage device 1 includes a drug storage bottle body 101, and the inner cavity of the drug storage bottle body 101 is provided with a spacer separating the inner cavity of the drug storage bottle body 101 into two chambers, and different chambers are separated from each other before use of the medicine, and the different chambers are used when the medicine is used. They are mutually conductive. Specifically, after the spacer is subjected to external pressure, the isolation function will be broken to make the different cavities conduct, so that the active ingredient of the medicament is separated from the solution before use, and the external pressure can be mixed when used. The effect is to improve the effect of the medicament.
  • the drug storage bottle body 101 is made of a plastic deformation material
  • the separator includes a first sealing film 108
  • the first sealing film 108 is fixedly connected to the inner wall of the drug storage bottle body 101.
  • the first sealing film 108 is disposed between the bottle mouth 102 of the drug storage bottle body 101 and the bottle bottom 103, and the first sealing film 108 separates the inner cavity of the drug storage bottle body 101 into the first The cavity 105 and the second cavity 106.
  • the first sealing film 108 is a flexible sealing film, and the first sealing film 108 is easily broken under an external force. Specifically, an external force is applied to the side wall of the drug storage bottle body 101 to force the deformation of the drug storage bottle body 101, thereby rupturing the first sealing film 108, so that the first cavity 105 is The second cavity 106 is electrically connected.
  • the multi-chamber atomization device further includes an atomizing sheet 2 and a flow guiding joint 3, and the atomizing sheet 2 is mounted at one end of the flow guiding joint 3, and the flow guiding joint 3 is provided with an inclined flow channel 31 communicating with the atomizing sheet 2, and the multi-chamber drug storage device 1 is mounted on the inclined flow channel 31 away from the atomizing sheet 2
  • the inclined flow path 31 is inclined upward toward an end close to the multi-chamber drug storage device 1 along an end close to the atomizing sheet 2.
  • the angle between the axis of the inclined flow path 31 and the horizontal plane is 10 degrees.
  • the total residual amount of the liquid medicine below the liquid level calibration line for the normal operation of the atomizing sheet 2 includes two parts, the first part is the residual amount in the inclined flow channel 31, and the second part is the flow guiding joint 3 away from the The residual amount in the mounting groove at one end of the liquid storage container.
  • the residual amount of the first portion decreases as the inclination angle of the inclined flow passage 31 increases. Therefore, the present embodiment connects the atomization sheet 2 and the liquid storage container through the flow guiding joint 3, and the inclined portion is opened on the flow guiding joint 3.
  • the flow passage 31 and the inclined flow passage 31 of the inclined design can reduce the liquid storage space below the normal working liquid level of the atomizing sheet 2, effectively reducing the volume of the chemical liquid remaining in the atomizer which cannot be atomized, thereby reducing waste.
  • the inclined flow channel 31 is disposed away from the one end of the atomizing sheet 2 with a container interface 32.
  • the bottle opening 102 of the multi-chamber drug storage device 1 is disposed at a position of a container joint 104.
  • a joint 104 is inserted into the container interface 32.
  • the axis line of the container interface 32 is on the same line as the axis line of the inclined flow path 31. In other embodiments, the axis of the container interface is parallel to the horizontal plane; or the axis of the container interface is perpendicular to the horizontal plane.
  • the atomization device further includes a housing 4, the flow guiding joint 3 is detachably connected to the housing 4, and the multi-chamber drug storage device 1 and the flow guiding joint 3 Removable connection.
  • the atomization device further includes a rectifying ring 5 mounted at an end of the flow guiding joint 3 away from the multi-chamber drug storage device 1, the rectifying ring 5 and the The inclined flow path 31 holds the atomizing sheet 2.
  • the atomization device further includes an electronic control unit 6 mounted in the housing 4, and the electric control unit 6 and the guide unit 3 are mounted on the housing 4.
  • the atomizing sheet 2 is electrically connected.
  • the electronic control unit 6 includes a time control element and a voltage control element, and the time control element is electrically connected to the atomizing sheet 2 for controlling the working time of the atomizing sheet 2;
  • the atomizing sheet 2 is electrically connected for supplying an operating voltage to the atomizing sheet 2.
  • the atomization efficiency of the atomizing sheet 2 is solidified, and therefore, The operation of the atomizing sheet 2
  • the total amount of drug atomization achieved by the atomizing sheet 2 is fixed, and the total amount of atomization is equal to the product of the atomization efficiency and the working time. Therefore, by controlling the atomization efficiency and the working time, the program can control the total amount of atomization of the therapeutic drug and improve the accuracy of the patient's medication.
  • Embodiment 2 is a diagrammatic representation of Embodiment 1:
  • the spacer divides the inner cavity of the drug storage bottle body 101 into three cavities, and the spacer further includes a second sealing film 109, and the second sealing film 109 is located at the Between the first sealing film 108 and the bottom 103 of the drug storage bottle body 101, the second sealing film 109 is fixedly coupled to the inner wall of the drug storage bottle body 101, the first sealing film 108 and the The second sealing film 109 divides the inner cavity of the drug storage bottle body 101 into a first volume 105, a second volume 106, and a third volume 107.
  • the second sealing film 109 is a flexible sealing film, and the second sealing film 109 is easily broken under an external force.
  • an external force is applied to the side wall of the drug storage bottle body 101 to force the deformation of the drug storage bottle body 101, thereby rupturing the first sealing film 108 and the second sealing film 109, so that the The first cavity 105 and the second cavity 106 are electrically connected to the third cavity 107.
  • Embodiment 3 is a diagrammatic representation of Embodiment 3
  • the spacer divides the inner cavity of the drug storage bottle body into four cavities, the spacer further includes a third sealing film, and the third sealing film is located at the second sealing film and the drug storage
  • the third sealing film is fixedly connected to the inner wall of the drug storage bottle body between the bottle bottoms of the bottle body, and the third sealing film is a flexible sealing film.
  • the first sealing film, the second sealing film and the third sealing film divide the inner cavity of the drug storage bottle body into a first cavity, a second cavity, a third cavity and a fourth cavity.
  • the isolation The piece may also divide the inner cavity of the vial body into five or more cavities.
  • Embodiment 4 is a diagrammatic representation of Embodiment 4:
  • a multi-chamber atomization device comprising a multi-chamber drug storage device 1 , as shown in FIGS. 7 to 9 , the multi-chamber drug storage device 1 includes a drug storage bottle body 101 inside the drug storage bottle body 101
  • the cavity is provided with a spacer, and the spacer divides the inner cavity of the drug storage bottle body 101 into two cavityes. Before the drug is used, different cavityes are separated from each other, and when the medicine is used, different places are used.
  • the chambers are electrically connected to each other. Specifically, after the spacer is subjected to external pressure, the isolation function will be broken to make the different cavities conduct, so that the active ingredient of the medicament is separated from the solution before use, and the external pressure can be mixed when used. The effect is to improve the effect of the medicament.
  • the drug storage bottle body 101 is made of a rigid material, and the spacer includes a first partition plate 110, and the first partition plate 110 is slidably connected to an inner wall of the drug storage bottle body 101.
  • the inner cavity of the drug storage bottle body 101 is outwardly extended with a first convex cavity 111, and the width of the first convex cavity 111 is greater than the thickness of the first separator 110, and the drug storage
  • the inner cavity of the bottle body 101 and the side of the spacer away from the bottle opening 102 of the drug storage bottle body 101 are provided with a rear partition plate 114, and the rear partition plate 114 and the inner wall of the drug storage bottle body 101
  • the sliding connection, the sum of the thickness of the rear partition 114 and the thickness of the first partition 110 is greater than the width of the first convex cavity 111.
  • the width of the first convex cavity 111 refers to the dimension of the first convex cavity 111 along the line connecting the bottle mouth 102 of the drug storage bottle body 101 and the bottom 103;
  • the thickness of a partition plate 110 refers to the dimension of the first partition plate 110 along the line direction of the bottle opening 102 of the drug storage bottle body 101 and the bottom 103 of the bottle.
  • the first partition 110 divides the inner cavity of the drug storage bottle body 101 into a first cavity 105 and a second cavity 10G. Before the drug is used, the first partition 110 is located at a side of the first convex cavity 111 away from the bottle opening 102 of the drug storage bottle body 101. When in use, an external force is applied to the rear partition 114 to drive The rear partition 114 moves in a direction close to the first partition 110. When the medicament in the second chamber 10G is compressed to a certain extent, the rear partition 114 will drive through the compressed medicament.
  • the first partition plate 110 moves in the direction of the first convex cavity 111 until the first partition plate 110 reaches the position of the first convex cavity 111, due to the first convex cavity
  • the width of the first partition 110 is greater than the thickness of the first partition 110.
  • the first convex cavity 111 forms a conductive interval 115 on both sides of the first partition 110, so that the first cavity 105 is Conducting with the second cavity 10G, at which time the pressure in the second cavity 10G is released, and the first spacer 110 cannot be continuously driven to move, so that the first spacer 110 stays in the Positioning the first cavity 111 to maintain the first cavity 105 and the second cavity 10G in a conducting state, and finally bonding the rear partition 114 to the first partition 110 At this time, the application of an external force to the rear partition 114 is stopped.
  • the conduction gap 115 is closed, so that the medicament cannot be removed from the The rear partition 114 leaks, thereby avoiding waste of the medicament and ensuring hygiene of the medicament.
  • the multi-chamber atomization device further includes an atomizing sheet 2 and a flow guiding joint 3, and the atomizing sheet 2 is mounted at one end of the flow guiding joint 3, and the flow guiding joint 3 is provided with an inclined flow channel 31 communicating with the atomizing sheet 2, and the multi-chamber drug storage device 1 is mounted on the inclined flow channel 31 away from the atomizing sheet 2
  • the inclined flow path 31 is inclined upward toward an end close to the multi-chamber drug storage device 1 along an end close to the atomizing sheet 2.
  • the angle between the axis of the inclined flow path 31 and the horizontal plane is 70 degrees.
  • the angle between the axis of the inclined flow channel and the horizontal plane may also be 15 degrees or 20 degrees or 25 degrees or 30 degrees or 35 degrees or 40 degrees or 45 degrees or 50 degrees or 55. Degree or 60 degrees or 65 degrees.
  • the total residual amount of the liquid medicine below the liquid level calibration line of the atomizing sheet 2 working normally includes two parts.
  • the first portion is the residual amount in the inclined flow path 31, and the second portion is the residual amount of the flow guiding joint 3 in the mounting groove away from the end of the liquid storage container.
  • the residual amount of the first portion decreases as the inclination angle of the inclined flow passage 31 increases. Therefore, the present embodiment connects the atomization sheet 2 and the liquid storage container through the flow guiding joint 3, and the inclined portion is opened on the flow guiding joint 3.
  • the flow passage 31 and the inclined flow passage 31 of the inclined design can reduce the liquid storage space below the normal working liquid level of the atomizing sheet 2, effectively reducing the volume of the chemical liquid remaining in the atomizer which cannot be atomized, thereby reducing waste.
  • the inclined flow channel 31 is disposed away from the one end of the atomizing sheet 2 with a container interface 32.
  • the bottle opening 102 of the multi-chamber drug storage device 1 is disposed at a position of a container joint 104.
  • a joint 104 is inserted into the container interface 32.
  • the atomizing device further comprises a housing 4, the flow guiding joint 3 being detachably connected to the housing 4, the multi-chamber drug storage device 1 being detachably connected to the flow guiding joint 3.
  • the atomization device further includes a rectifying ring 5 mounted at an end of the flow guiding joint 3 away from the multi-chamber drug storage device 1, the rectifying ring 5 and the The inclined flow path 31 holds the atomizing sheet 2.
  • the atomization device further includes an electronic control unit 6 mounted in the housing 4, and the electric control unit 6 and the guide unit 3 are mounted on the housing 4.
  • the atomizing sheet 2 is electrically connected.
  • the electronic control unit 6 includes a time control element and a voltage control element, and the time control element is electrically connected to the atomizing sheet 2 for controlling the working time of the atomizing sheet 2;
  • the atomizing sheet 2 is electrically connected for supplying an operating voltage to the atomizing sheet 2.
  • Embodiment 5 is a diagrammatic representation of Embodiment 5:
  • the spacer divides the inner cavity of the vial body 101 into three cavities, the spacer further includes a second baffle 112, and the second baffle 112 is located at the First partition 110 and said The second partition plate 112 is slidably connected to the inner wall of the drug storage bottle body 101.
  • the inner cavity of the drug storage bottle body 101 is outwardly extended with a second convex cavity 113.
  • the width of the second convex cavity 113 is greater than the thickness of the second partition 112, and the second convex cavity 113 is located between the first convex cavity 111 and the rear partition 114.
  • the sum of the thickness of the rear partition 114 and the thickness of the second partition 112 is greater than the width of the second convex cavity 113.
  • the first partition 110 and the second partition 112 divide the inner cavity of the vial body 101 into a first volume 105, a second volume 106 and a third volume 107.
  • the second partition 112 is located on a side of the second convex cavity 113 away from the bottle opening 102 of the drug storage bottle body 101.
  • the width of the first convex cavity 111 is equal to the width of the second convex cavity 113
  • the thickness of the first partition 110 is equal to the thickness of the second partition 112.
  • the spacer may also divide the inner cavity of the vial body 101 into four or more cavities.
  • the number of the first convex cavities is two, and the two first convex cavities are equally spaced along the circumferential direction of the drug storage bottle body, all of the first convex cavity and the The distance between the mouths of the drug storage bottle body is equal. Providing a plurality of the first convex cavities can increase the conduction area between different cavities and improve the efficiency of mixing.
  • the number of the first convex cavities is two, the number of the second convex cavities is two, and the two first convex cavities are equally spaced along the circumferential direction of the drug storage bottle body. Distribution, all of the first protrusions The distance between the cavity and the mouth of the drug storage bottle body is equal; two of the second convex cavity are equally spaced along the circumferential direction of the drug storage bottle body, and all of the second convex volume The distance between the cavity and the mouth of the drug storage bottle body is equal, and the distance between the second convex cavity and the bottle mouth of the drug storage bottle body is greater than the first convex cavity and the cavity The distance between the mouths of the storage bottle body.
  • the number of the first convex cavities may be 3 or 4 or 5 or 6 or 7 or 8 or 9 or 10; the second convex cavity The number can be 3 or 4 or 5 or 6 or 7 or 8 or 9 or 10.
  • the flow path on the flow guiding joint 3 is a horizontal flow path, and the horizontal flow path is in communication with the atomizing sheet 2, and the multi-chamber drug storage device 1 is installed in the The horizontal flow path is away from the side of the atomizing sheet 2.
  • the axial line of the horizontal flow path is parallel to the horizontal plane, and the axial line of the multi-chamber drug storage device 1 is on the same line as the axial line of the horizontal flow path.

Abstract

Brumisateur mutliperforé comprenant un dispositif multiperforé de stockage (1) de médicaments, lequel (1) comprend un flacon de stockage (101) de médicaments contenant un séparateur, ce dernier formant au moins deux récipients au sein du flacon de stockage (101) de médicaments. Après avoir subi la pression d'une partie externe, le séparateur met en communication différents espaces qui seront brisés. Avant l'utilisation d'un médicament, les différents espaces se séparent, ainsi lors de l'administration du médicament, les différents espaces acheminent celui-ci, ce qui garantit le bon état du médicament avant son utilisation grâce à l'isolement des liquides. Lors de la prise du médicament, la pression exercée par la partie externe mélange les liquides, ce qui optimise l'action du médicament.
PCT/CN2017/106286 2016-10-17 2017-10-16 Brumisateur mutliperforé WO2018072665A1 (fr)

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