WO2018072212A1 - 血压测量设备的校准方法及血压测量设备 - Google Patents

血压测量设备的校准方法及血压测量设备 Download PDF

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Publication number
WO2018072212A1
WO2018072212A1 PCT/CN2016/102947 CN2016102947W WO2018072212A1 WO 2018072212 A1 WO2018072212 A1 WO 2018072212A1 CN 2016102947 W CN2016102947 W CN 2016102947W WO 2018072212 A1 WO2018072212 A1 WO 2018072212A1
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Prior art keywords
blood pressure
historical
calibration
confidence
measuring device
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PCT/CN2016/102947
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English (en)
French (fr)
Inventor
许培达
陈文娟
朱萸
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华为技术有限公司
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Application filed by 华为技术有限公司 filed Critical 华为技术有限公司
Priority to US16/343,384 priority Critical patent/US11330991B2/en
Priority to EP16919380.2A priority patent/EP3524137B1/en
Priority to PCT/CN2016/102947 priority patent/WO2018072212A1/zh
Priority to CN201680080820.3A priority patent/CN108601527B/zh
Publication of WO2018072212A1 publication Critical patent/WO2018072212A1/zh

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/02Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/021Measuring pressure in heart or blood vessels
    • A61B5/022Measuring pressure in heart or blood vessels by applying pressure to close blood vessels, e.g. against the skin; Ophthalmodynamometers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/02Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/021Measuring pressure in heart or blood vessels
    • A61B5/02108Measuring pressure in heart or blood vessels from analysis of pulse wave characteristics
    • A61B5/02125Measuring pressure in heart or blood vessels from analysis of pulse wave characteristics of pulse wave propagation time
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/02Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/021Measuring pressure in heart or blood vessels
    • A61B5/02108Measuring pressure in heart or blood vessels from analysis of pulse wave characteristics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/02Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/024Detecting, measuring or recording pulse rate or heart rate
    • A61B5/02416Detecting, measuring or recording pulse rate or heart rate using photoplethysmograph signals, e.g. generated by infrared radiation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/72Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7221Determining signal validity, reliability or quality
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2560/00Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
    • A61B2560/02Operational features
    • A61B2560/0223Operational features of calibration, e.g. protocols for calibrating sensors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/02Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/021Measuring pressure in heart or blood vessels
    • A61B5/02141Details of apparatus construction, e.g. pump units or housings therefor, cuff pressurising systems, arrangements of fluid conduits or circuits
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/68Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6813Specially adapted to be attached to a specific body part
    • A61B5/6824Arm or wrist
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/68Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6813Specially adapted to be attached to a specific body part
    • A61B5/6825Hand
    • A61B5/6826Finger

Definitions

  • the present invention relates to the field of intelligent terminal technologies, and in particular, to a calibration method of a blood pressure measuring device and a blood pressure measuring device.
  • the user's blood pressure is mainly measured by a cuffless blood pressure measuring device, wherein the cuffless blood pressure measuring device uses the pulse wave transmission time to measure blood pressure, without using a cuff, and provides a convenient and comfortable measuring method for the user. . Since each person's arterial wall elasticity, blood density and other physiological parameters are different, the relationship between the pulse wave transmission time and the user's blood pressure is object dependent. Therefore, when measuring the user's blood pressure, the cuffless blood pressure measuring device will The user's blood pressure is calibrated to ensure that the cuffless blood pressure measuring device measures the accuracy of the blood pressure.
  • the current cuffless blood pressure measuring device when calibrating the blood pressure of each user, it is necessary to measure the standard blood pressure using an additional device (such as a cuff sphygmomanometer or a standard sphygmomanometer), and input the measured standard blood pressure.
  • the cuffless blood pressure measuring device obtains the user's real blood pressure and is costly.
  • the invention provides a calibration method and a blood pressure measuring device for a blood pressure measuring device, which can ensure the accuracy of measuring blood pressure information, and avoid the calibration of measuring blood pressure information by means of an additional device.
  • a calibration method of a blood pressure measurement device includes: acquiring first blood pressure measurement information of the blood pressure measurement device, and current confidence corresponding to the first blood pressure measurement information, the first blood pressure measurement The information includes a first systolic pressure value and/or a first diastolic pressure value; determining whether the historical calibration parameter list is included in the blood pressure measuring device, the historical calibration parameter list including historical blood pressure calibration information and the historical blood pressure calibration information Historical confidence, the historical blood The pressure calibration information includes a historical systolic pressure value and/or a historical diastolic pressure value; if the blood pressure measuring device includes a historical calibration parameter list, and the current confidence level is greater than or equal to a preset reliability, or greater than or equal to the history In the confidence level, the first blood pressure measurement information is determined as blood pressure calibration information of the blood pressure measuring device, and the historical calibration parameter list is updated according to the first blood pressure measurement information and the current confidence.
  • the non-calibration result is applied to the manual calibration measurement, which ensures the accuracy of the measured blood pressure and reduces the user's self-calibration with additional equipment.
  • the number of times, and the calibration of the measured blood pressure information by means of the additional device is avoided, so that the blood pressure measuring device measures the cost of the blood pressure information and has high portability.
  • the physiological signal of the blood pressure measuring device is acquired, and the physiological signal includes: a user's ECG signal and/or a user's pulse wave signal;
  • the second blood pressure measurement information of the blood pressure measuring device is determined according to the historical blood pressure calibration information and the physiological signal, and the second blood pressure measurement information includes: a second systolic pressure value and/or a second diastolic pressure value; a current blood pressure difference value between the first measured blood pressure information and the second blood pressure measurement information; if the current blood pressure difference value is greater than or equal to a preset blood pressure difference value, and the current confidence level is greater than or equal to the preset reliability, the calibration counter Adding 1 and determining, when the calibration counter value is greater than or equal to a preset value, the first blood pressure measurement information as blood pressure calibration information of the blood pressure measuring device, and clearing the calibration counter, and according to the first blood pressure
  • the current confidence level of the first measured blood pressure is less than the historical confidence of the historical blood pressure calibration information, determining whether the difference between the first measured blood pressure and the second measured blood pressure is greater than a preset blood pressure value, and determining the current confidence of the first measured blood pressure Whether the degree is greater than a preset threshold to determine whether the accuracy of the first measured blood pressure measured by the non-calibration measurement module is greater than the second measured blood pressure measured by the calibration measurement module, thereby determining the first measured blood pressure as the availability of the calibration information.
  • the current blood pressure difference value between the first measured blood pressure information and the second blood pressure measurement information may be obtained by the following feasible implementation manners:
  • Another possible implementation manner is: according to the first diastolic pressure value and the second diastolic pressure value, Determining the current blood pressure difference value;
  • Yet another possible implementation manner determining the current current according to a ratio of the first systolic pressure value to the first diastolic pressure value, and a ratio of the second systolic pressure value to the second diastolic pressure value Blood pressure difference value.
  • acquiring the current confidence level corresponding to the first blood pressure measurement information comprising: acquiring the current confidence level according to at least one of the following parameters: blood pressure input data of the blood pressure measurement device The signal quality of the physiological signal of the blood pressure measuring device, the historical blood pressure input data of the blood pressure measuring device, or the historical physiological signal data of the blood pressure measuring device.
  • the current confidence corresponding to the first blood pressure measurement information is acquired according to the at least one parameter, so that the first measured blood pressure can be more accurately determined as the availability of the calibration information.
  • acquiring a current confidence level corresponding to the first blood pressure measurement information includes: acquiring a first confidence level according to a signal quality of the physiological signal; and obtaining the difference according to the first blood pressure measurement information and the historical blood pressure calibration information a second confidence; obtaining a third confidence according to the similarity between the blood pressure input data of the blood pressure measuring device and the historical input data; weighting and summing the first confidence, the second confidence, and the third confidence to obtain the first blood pressure The current confidence in the measurement information.
  • the current confidence level corresponding to the first blood pressure measurement information is obtained by implementing an implementation of calculating the current confidence of the first measured blood pressure based on the blood pressure input data, the physiological signal, and the first measured blood pressure, thereby determining the first measured blood pressure as the availability of the calibration information.
  • the blood pressure measurement device includes a first acquisition module, a confidence calculation module, a determination module, and a calibration update module, wherein
  • the first obtaining module is configured to acquire first blood pressure measurement information of the blood pressure measuring device, where the first blood pressure measurement information includes a first systolic pressure value and/or a first diastolic pressure value;
  • the confidence calculation module is configured to acquire a current confidence level corresponding to the first blood pressure measurement information
  • the determining module is configured to determine whether the historical calibration parameter list is included in the blood pressure measuring device, where the historical calibration parameter list includes historical blood pressure calibration information and historical confidence corresponding to the historical blood pressure calibration information, the historical blood pressure
  • the calibration information includes historical systolic pressure values and/or historical diastolic pressure values;
  • the calibration update module is configured to determine, in the determining module, that the blood pressure measuring device includes a historical calibration parameter list, and the current confidence is greater than or equal to a preset reliability, or greater than or equal to Determining, in the historical confidence, the first blood pressure measurement information as blood pressure calibration information of the blood pressure measuring device, and updating the historical calibration parameter list according to the first blood pressure measurement information and the current confidence .
  • the blood pressure measuring device provided by the second aspect of the present invention is used to perform the technical solution in the method embodiment of the first aspect, and the implementation principle and the technical effect are similar, and details are not described herein again.
  • the blood pressure measurement device further includes a second acquisition module, where
  • the second acquiring module is configured to acquire a physiological signal of the blood pressure measuring device when the determining module determines that the blood pressure measuring device does not include the historical calibration parameter list, where the physiological signal includes: an ECG signal of the user And/or the pulse wave signal of the user;
  • the first obtaining module is further configured to: when the current confidence is less than the historical confidence, determine the second blood pressure measurement information of the blood pressure measuring device according to the historical blood pressure calibration information and the physiological signal,
  • the second blood pressure measurement information includes: a second systolic pressure value and/or a second diastolic pressure value;
  • the calibration update module is further configured to acquire a current blood pressure difference value of the first measured blood pressure information and the second blood pressure measurement information, and the current blood pressure difference value is greater than or equal to a preset blood pressure difference value, and When the current confidence is greater than or equal to the preset reliability, the calibration counter is incremented by 1, and when the calibration counter value is greater than or equal to a preset value, the first blood pressure measurement information is determined as the blood pressure measurement device. Blood pressure calibration information, and clearing the calibration counter, and updating the historical calibration parameter list based on the first blood pressure measurement information and the current confidence.
  • the calibration update module is specifically configured to:
  • the confidence calculation module is specifically configured to:
  • Acquiring the current confidence level according to at least one of the following parameters: blood pressure input data of the blood pressure measuring device, signal quality of a physiological signal of the blood pressure measuring device, historical blood pressure input data of the blood pressure measuring device, or the Historical physiological signal data of blood pressure measuring devices.
  • the confidence calculation module is specifically configured to:
  • the first confidence, the second confidence, and the third confidence are weighted and summed to obtain a current confidence of the first blood pressure measurement information.
  • the blood pressure measuring device provided by the second aspect of the present invention is used to perform the technical solution in the method embodiment of the first aspect, and the implementation principle and the technical effect are similar, and details are not described herein again.
  • an embodiment of the present invention provides a blood pressure measuring device, including: a memory for storing an execution instruction, and a processor for invoking an execution instruction in the memory, and performing the following operations:
  • first blood pressure measurement information of the blood pressure measuring device Obtaining first blood pressure measurement information of the blood pressure measuring device and current confidence corresponding to the first blood pressure measurement information, the first blood pressure measurement information including a first systolic pressure value and/or a first diastolic pressure value;
  • the historical calibration parameter list including historical blood pressure calibration information and historical confidence corresponding to the historical blood pressure calibration information, the historical blood pressure calibration information including a historical contraction pressure value and / or historical diastolic pressure;
  • the blood pressure measuring device includes a historical calibration parameter list, and the current confidence is greater than or equal to a preset reliability, or greater than or equal to the historical confidence, determining the first blood pressure measurement information as the Blood pressure calibration information of the blood pressure measuring device, and updating the historical calibration parameter list based on the first blood pressure measurement information and the current confidence.
  • the blood pressure measuring device provided by the third aspect of the present invention is used to perform the technical solution in the method embodiment of the first aspect, and the implementation principle and the technical effect are similar, and details are not described herein again.
  • the processor is specifically configured to:
  • the blood pressure measuring device does not include the historical calibration parameter list, acquiring a physiological signal of the blood pressure measuring device, the physiological signal comprising: a user's ECG signal and/or the user's pulse wave signal;
  • the measurement information includes: a second systolic pressure value and/or a second diastolic pressure value;
  • the calibration counter is incremented by 1, and the calibration counter value is greater than or equal to the preset Numerical value, the first blood pressure measurement information is determined as blood pressure calibration information of the blood pressure measuring device, and the calibration counter is cleared, and the update is performed according to the first blood pressure measurement information and the current confidence level A list of historical calibration parameters.
  • the processor is specifically configured to:
  • the processor is specifically configured to:
  • Acquiring the current confidence level according to at least one of the following parameters: blood pressure input data of the blood pressure measuring device, signal quality of a physiological signal of the blood pressure measuring device, historical blood pressure input data of the blood pressure measuring device, or the Historical physiological signal data of blood pressure measuring devices.
  • the processor is specifically configured to:
  • the first confidence, the second confidence, and the third confidence are weighted and summed to obtain a current confidence of the first blood pressure measurement information.
  • the blood pressure measuring device provided by the third aspect of the present invention is used to perform the technical solution in the method embodiment of the first aspect, and the implementation principle and the technical effect are similar, and details are not described herein again.
  • the calibration method and the blood pressure measuring device of the blood pressure measuring device provided by the embodiment of the present invention by using the first measured blood pressure information directly measured according to the physiological signal of the user as the calibration information, The quasi-results are applied to the manual calibration measurement, which not only ensures the accuracy of the measured blood pressure, but also reduces the number of times the user self-calibrates with additional equipment, and avoids the calibration of the measured blood pressure information by means of additional equipment, so that the blood pressure measuring device measures The cost of blood pressure information is reduced and has high portability.
  • Figure 1 is a schematic diagram of measuring blood pressure of a user based on a pulse wave signal
  • FIG. 2 is a schematic diagram of measuring blood pressure of a user according to a pulse wave signal and an electrocardiographic signal
  • FIG. 3 is a schematic diagram of acquiring a PPT according to a pulse wave signal and an electrocardiographic signal
  • FIG. 4 is a flowchart of a calibration method of a blood pressure measuring device according to an embodiment of the present invention.
  • FIG. 5 is a flowchart of calculating a current confidence level of first measured blood pressure information according to an embodiment of the present invention
  • FIG. 6 is a schematic structural diagram of a blood pressure measuring device according to an embodiment of the present invention.
  • FIG. 7 is a schematic structural diagram of a blood pressure measuring device according to an embodiment of the present invention.
  • the technique for measuring blood pressure mainly measures the blood pressure of the user according to the physiological signal of the user (hereinafter referred to as the user), wherein the physiological signals of the user include: an electrocardiogram signal and/or a pulse wave signal, and the ECG signal is a user.
  • the heart is emitted when it is beating; the pulse wave signal is formed by the interaction of the user's blood in the blood vessels and the blood vessels.
  • FIG. 1 is a schematic diagram of measuring blood pressure of a user according to a pulse wave signal. As shown in FIG. 1 , blood flow parameters of blood flowing in a blood vessel are obtained by photoelectric volume pulse wave method according to a pulse wave signal, and the photoelectric volume pulse wave method is based on peripheral micro blood vessels.
  • Pulsating change of blood volume with heart beat, through photoplethysmographic pulse wave (Photoplethysmography, abbreviated as PPG)
  • PPG photoplethysmographic pulse wave
  • the PPG signal obtained by tracing wherein PPG tracing is a simple, low-cost optical measurement technique that can be used to detect changes in blood volume in tissue blood vessels.
  • the principle of measuring blood pressure according to the pulse wave signal is to place two photoelectric volume pulse wave sensors (such as PPG1 and PPG2 in Fig. 1) in the user's radial artery (position 1 in Fig. 1) and the middle finger artery (as in Fig. 1).
  • the distance between the two points of the artery can be obtained by measuring the distance between the radial artery and the middle finger artery, that is, the distance between the two points of the pulse wave passing through the artery is obtained, and the time at which the pulse wave is at position 1 is measured.
  • the pulse transit time PTT
  • the pulse wave velocity can be calculated from the distance between the two points of the artery and the transit time of the pulse wave (Pulse Wave Velocity).
  • PWV Pulse Wave Velocity
  • FIG. 2 is a schematic diagram of measuring blood pressure of a user according to a pulse wave signal and an electrocardiographic signal
  • FIG. 3 is a schematic diagram of acquiring a PPT according to a pulse wave signal and an electrocardiographic signal, as shown in FIG. 2 and FIG. 3, according to a reference point of the electrocardiographic signal and The reference point on the pulse wave signal detected during the same cardiac cycle measures the user's blood pressure.
  • the principle of measuring blood pressure based on the pulse wave signal and the electrocardiogram signal is to place the photoplethysmographic pulse wave sensor on the skin of the user's little thumb finger artery, and place the pressure pulse wave sensor on the skin of the user's wrist, by measuring the user's little finger finger artery (The distance between the two points of the artery can be obtained by the distance between the position 1) of FIG. 2 and the wrist (position 2 in FIG. 2), by measuring the time point of the pulse wave at the position 1 and the time point of the ECG signal at the position 2, PTT can be obtained, PWV is calculated according to the distance between the two points of the artery and PTT, and the blood pressure of the user is measured according to the linear relationship between PWV and blood pressure.
  • FIG. 4 is a flowchart of a calibration method of a blood pressure measuring device according to an embodiment of the present invention. As shown in FIG. 4, a calibration method of a blood pressure measurement device according to an embodiment of the present invention includes:
  • S401 Acquire first measured blood pressure information of the blood pressure measuring device.
  • the first blood pressure measurement information includes: a first systolic pressure value and/or a first diastolic blood pressure value, and the first measured blood pressure information is blood pressure information to be calibrated.
  • the calibration method of the blood pressure measurement device may be used in a calibration device of a blood pressure measurement device, and the calibration device of the blood pressure measurement device may be a terminal such as a mobile phone and a wearable device.
  • the blood pressure measuring device in this embodiment may include a first calibration measurement module and a second calibration measurement
  • the quantity module, the first calibration measurement module is a non-calibration measurement module, and the second calibration measurement module is a calibration measurement module.
  • the user can input personal information (such as height, weight, age and gender) and collection by the user.
  • a physiological signal (30 seconds) of a certain duration is used to enable the non-calibration measurement module, and the non-calibration measurement module can acquire at least one physiological signal of the user, such as an electrocardiogram signal and/or a pulse wave signal, and acquire the user according to the collected physiological signal.
  • the first measurement blood pressure information is used as the first measurement blood pressure information of the blood pressure measurement device.
  • SBP Systolic pressure
  • DBP Diastolic pressure
  • PTT Pulse Transit Time
  • the ECG signal in this embodiment may be measured by a light sensor, a pressure sensor, an acoustic sensor, a photoelectric sensor, an acceleration sensor or a displacement sensor, and the pulse wave may be characterized by collecting a photoplethysmographic signal by the photoelectric sensor.
  • the non-calibration measurement module to obtain the user's measured blood pressure information according to the physiological signal of the user, refer to the descriptions in FIG. 1 and FIG. 2 above, and the embodiment is not limited and described herein.
  • the user can set the non-calibration measurement module by inputting the user's personal information (such as height, weight, age and gender) and collecting physiological signals (30 seconds) for a certain period of time.
  • each user account stores the personal information of the corresponding user.
  • log in directly with an existing account For the first-time user, you need to register a new account name, and the user enters the user's personal information under the account name.
  • the non-calibration measurement module can directly obtain the user information stored under the account name, and determine whether there is historical blood pressure calibration information in the calibration database under the account name.
  • the embodiment of the present invention measures the accuracy of the first measured blood pressure information by using the confidence level to determine the first measured blood pressure information measured by the non-calibration measurement module as the availability of the calibration information.
  • the current confidence may be obtained according to at least one of the following parameters: blood pressure input data of the blood pressure measuring device, signal quality of the physiological signal of the blood pressure measuring device, historical blood pressure input data of the blood pressure measuring device, or history of the blood pressure measuring device Physiological signal data.
  • the current confidence level corresponding to the first measured blood pressure information (which may be referred to as the current confidence level) may be calculated according to one or a combination of the following: First, it is determined according to the external user blood pressure input data acquired by the non-calibration measurement module. First, the current confidence of the blood pressure information is measured, second, the current confidence of the first measured blood pressure information is determined according to the historical blood pressure input data of the user acquired by the calibration measurement module, and the third, non-calibration measurement module is based on the physiological signal of the collected user.
  • the calibration measurement module calculates the signal quality of the user's historical physiological signal ( For example, signal-to-noise ratio, AC-DC ratio, signal strength, etc., the signal quality is mapped to the current confidence of the first measured blood pressure information, and the fifth, the non-calibrated measurement module directly provides the confidence as the current measurement of the first blood pressure information.
  • Confidence, sixth calculate first according to blood pressure input data, physiological signal and first measured blood pressure information Current confidence blood pressure information.
  • the current confidence level corresponding to the first blood pressure measurement information is obtained, including: acquiring a first confidence level Q1 according to a signal quality of the physiological signal; and acquiring a second confidence level Q2 according to the difference between the first measured blood pressure information and the preset calibration information.
  • the current confidence level (which may be referred to as the current confidence level) corresponding to the first measured blood pressure information is jointly calculated according to the blood pressure input data, the physiological signal, and the first measured blood pressure information, and FIG. 5 is provided by the embodiment of the present invention. a flowchart for calculating a current confidence level of the first measured blood pressure information, as shown in FIG.
  • the weighting weight ⁇ i can be a fixed value. It can also be calculated according to the analytic hierarchy process, and the present embodiment is not limited and described herein. It should be noted that, in this embodiment, the arithmetic mean value of the first confidence level Q1, the second confidence level Q2, and the third confidence level Q3 may be used as the current confidence level Q of the first measured blood pressure information.
  • S403 Determine whether a history calibration parameter list is included in the blood pressure measurement device. If the history calibration parameter list is not included in the blood pressure measurement device, S404 is performed; if the blood pressure measurement device includes the history calibration parameter list, S406 is performed.
  • the historical calibration parameter list includes historical confidence values corresponding to historical blood pressure calibration information and historical blood pressure calibration information, and the historical blood pressure calibration information includes historical systolic pressure values and/or historical diastolic blood pressure values.
  • the blood pressure measurement device includes a historical calibration parameter list to determine whether the calibration of the user blood pressure measurement device is a historical calibration scene or a historyless calibration scenario, to determine how to set the blood pressure measurement in the subsequent steps.
  • the historical blood pressure calibration information may include: SBP, DBP, and PTT.
  • the historical blood pressure calibration information may be derived from the user's own actual blood pressure data.
  • the historical blood pressure calibration information has a historical confidence of 1, and the historical blood pressure calibration information is also
  • the first measured blood pressure information may be measured from the non-calibrated measurement module, at which time the historical confidence of the historical blood pressure calibration information is the current confidence of the first measured blood pressure information.
  • S402 and S403 may be interchanged, and S403 may be performed first, and then S402 is performed. This embodiment is not limited and described herein.
  • S404 Determine whether the current confidence of the first measured blood pressure information is greater than or equal to the preset reliability. If the current confidence of the first measured blood pressure information is greater than or equal to the preset reliability, then S405 is performed; otherwise, it ends.
  • the embodiment may directly use the first measured blood pressure information as the calibration information for calibration. Before the first measured blood pressure information is calibrated as the calibration information, the current confidence of the first measured blood pressure information needs to be determined to determine the availability of the first measured blood pressure information measured by the non-calibrated measurement module as the calibration information.
  • S405 Determine the first blood pressure measurement information as the blood pressure calibration information of the blood pressure measuring device, and update the historical calibration parameter list according to the first blood pressure measurement information and the current confidence.
  • the first measured blood pressure information can be used as the blood pressure calibration information.
  • the calibration measurement module may calculate the blood pressure according to the first measured blood pressure information and the collected user physiological signal, and specifically may use the first measured blood pressure information to calibrate the measured blood pressure information acquired according to the user's physiological signal to output the user's
  • the actual blood pressure matches the measured blood pressure information and is updated according to the first blood pressure measurement information and current confidence
  • the historical calibration parameter list since no historical calibration information is detected in S403, that is, the history list is not included, it can be understood that the update history calibration parameter list, that is, the historical calibration parameter list is established.
  • the process ends without subsequent processing.
  • S407 Determine whether the current confidence of the first measured blood pressure information is greater than or equal to the historical confidence. If the current confidence of the first measured blood pressure information is greater than or equal to the historical confidence, then S408 is performed; otherwise, S409 is performed.
  • S408 Determine the first blood pressure measurement information as the blood pressure calibration information of the blood pressure measuring device, and update the historical calibration parameter list according to the first blood pressure measurement information and the current confidence.
  • the current confidence of the first measured blood pressure information is greater than or equal to the historical confidence corresponding to the historical blood pressure calibration information
  • the current confidence of the first measured blood pressure information The degree is high, the error between the first measured blood pressure information and the actual blood pressure of the user is small, and the accuracy of the blood pressure measured by the non-calibration measuring module is high, and the first measured blood pressure information can be used as the blood pressure calibration information, that is, the calibration measuring module
  • the blood pressure may be calculated according to the first measured blood pressure information and the collected user physiological signal, and specifically, the first measured blood pressure information may be used, and the measured blood pressure information acquired according to the physiological signal of the user is calibrated to output a measurement that matches the actual blood pressure of the user. Blood pressure information, and the historical calibration parameter list is updated based on the first blood pressure measurement information and the current confidence.
  • S409 Determine second blood pressure measurement information of the blood pressure measuring device according to the historical blood pressure calibration information and the physiological signal.
  • the second blood pressure measurement information includes: a second systolic pressure value and/or a second diastolic pressure value.
  • the physiological signal of the blood pressure measuring device is acquired, and the physiological signal includes: the user's ECG signal and/or the user's pulse wave signal.
  • the embodiment determines the blood pressure measuring device according to the historical blood pressure calibration information and the physiological signal.
  • the second blood pressure measurement information is specifically obtained by using the historical blood pressure calibration information to calibrate the measured blood pressure of the user acquired according to the physiological signal, and obtaining the second measured blood pressure information.
  • S410 Obtain a current blood pressure difference value of the first measured blood pressure information and the second blood pressure measurement information.
  • the current blood pressure difference value of the first measured blood pressure information and the second measured blood pressure information may be determined according to the current blood pressure difference value of the first systolic pressure value and the second systolic pressure value, or may be according to the first diastolic pressure value and the second
  • the current blood pressure difference value of the diastolic blood pressure value determines a current blood pressure difference value between the first measured blood pressure information and the second measured blood pressure information, and may also be based on a ratio of the first systolic blood pressure value to the first diastolic blood pressure value, and a second systolic blood pressure value and The ratio of the second diastolic blood pressure value determines a current blood pressure difference value between the first measured blood pressure information and the second measured blood pressure information.
  • the first measured blood pressure information is used for calibration by determining the current blood pressure difference value of the first measured blood pressure information and the second measured blood pressure information to determine whether the first measured blood pressure information can be used as the calibration information.
  • S411 Determine whether the current blood pressure difference value is greater than a preset blood pressure difference value, and determine whether the current confidence level of the first measured blood pressure information is greater than a preset reliability. If the current blood pressure difference value is greater than or equal to the preset blood pressure difference value, and the current confidence of the first measured blood pressure information is greater than or equal to the preset reliability, then S412 is performed; otherwise, the process ends.
  • the current confidence of the first measured blood pressure information is less than the historical confidence of the historical blood pressure calibration information
  • determining the first measured blood pressure information and the second measured blood pressure Whether the difference of the information is greater than a preset blood pressure value, and determining whether the current confidence of the first measured blood pressure information is greater than a preset reliability to determine whether the accuracy of the first measured blood pressure information measured by the non-calibrated measurement module is greater than the calibration measurement
  • the second measured blood pressure information measured by the module determines the first measured blood pressure information as the availability of the calibration information.
  • the embodiment of the present invention may further be provided with a calibration counter.
  • a calibration counter When it is determined in S410 that the difference between the first measured blood pressure information and the second measured blood pressure information is greater than a preset blood pressure value, and determining that the current confidence of the first measured blood pressure information is greater than The calibration counter is incremented by 1 when the reliability is preset.
  • S413 Determine whether the calibration counter value is greater than or equal to a preset value. If the number of calibration counters If the value is greater than or equal to the preset value, then S414 is performed; otherwise, it ends.
  • the calibration counter value is compared with a preset value, where the preset value may be, for example, 3, 4, 5, etc., for example, 5 in this embodiment, to further determine the first measured blood pressure information as Availability of calibration information.
  • S414 Determine the first blood pressure measurement information as blood pressure calibration information of the blood pressure measuring device, and clear the calibration counter, and update the historical calibration parameter list according to the first blood pressure measurement information and the current confidence.
  • the accuracy of the first measured blood pressure information is relatively high, and the first measured blood pressure information may be used to calibrate the user's measured blood pressure information, and the history is The blood pressure calibration information is updated to the first measured blood pressure information, the historical confidence of the historical blood pressure calibration information is updated to the current confidence of the first measured blood pressure information, and the calibration counter is cleared to implement an update of the calibration database and an update of the calibration counter.
  • the calibration method of the blood pressure measurement device uses the first measurement blood pressure information directly measured according to the physiological signal of the user as the calibration information, and applies the non-calibration result to the manual calibration measurement, thereby ensuring the measured blood pressure.
  • Accuracy also reduces the number of times the user self-calibrates with additional equipment, and avoids the calibration of the measured blood pressure information by means of additional equipment, so that the blood pressure measuring device can reduce the cost of measuring blood pressure information, and has high portability; Determining whether there is historical blood pressure calibration information in the calibration information base, using two different algorithms to determine the first measured blood pressure information as the availability of the calibration information, and updating the historical blood pressure calibration information to when the historical blood pressure calibration information is in the calibration information base
  • the first measurement of the blood pressure information is such that the updated historical blood pressure calibration information matches the actual blood pressure of the user as much as possible, further ensuring the accuracy of measuring the blood pressure information.
  • the current confidence level of the first measured blood pressure is less than the historical confidence of the historical blood pressure calibration information, determining whether the difference between the first measured blood pressure and the second measured blood pressure is greater than a preset blood pressure value, and determining the current confidence of the first measured blood pressure Whether the degree is greater than a preset threshold to determine whether the accuracy of the first measured blood pressure measured by the non-calibration measurement module is greater than the second measured blood pressure measured by the calibration measurement module, thereby determining the first measured blood pressure as the availability of the calibration information.
  • FIG. 6 is a schematic structural diagram of a blood pressure measuring device according to an embodiment of the present invention. As shown in FIG. 6, the first obtaining module 61, the confidence calculating module 62, the determining module 63, and the calibration updating module 64 are included, wherein
  • the first obtaining module 61 is configured to acquire a first blood pressure measurement signal of the blood pressure measuring device
  • the first blood pressure measurement information includes a first systolic pressure value and/or a first diastolic pressure value
  • the confidence calculation module 62 is configured to acquire a current confidence level corresponding to the first blood pressure measurement information
  • the determining module 63 is configured to determine whether the historical calibration parameter list is included in the blood pressure measuring device, where the historical calibration parameter list includes historical blood pressure calibration information and historical confidence corresponding to the historical blood pressure calibration information, the history Blood pressure calibration information includes historical systolic blood pressure values and/or historical diastolic blood pressure values;
  • the calibration update module 64 is configured to determine, in the determining module 63, that the blood pressure measuring device includes a historical calibration parameter list, and the current confidence level is greater than or equal to a preset reliability, or greater than or equal to the historical confidence. And determining the first blood pressure measurement information as blood pressure calibration information of the blood pressure measuring device, and updating the historical calibration parameter list according to the first blood pressure measurement information and the current confidence.
  • the blood pressure measuring device can perform the technical solutions shown in the foregoing method embodiments, and the implementation principle and the beneficial effects thereof are similar, and details are not described herein.
  • the blood pressure measurement device further includes a second acquisition module 65, wherein
  • the second obtaining module 65 is configured to acquire a physiological signal of the blood pressure measuring device when the determining module 63 determines that the blood pressure measuring device does not include the historical calibration parameter list, where the physiological signal includes: a user's heart An electrical signal and/or a pulse wave signal of the user;
  • the first obtaining module 61 is further configured to: when the current confidence is less than the historical confidence, determine the second blood pressure measurement information of the blood pressure measuring device according to the historical blood pressure calibration information and the physiological signal,
  • the second blood pressure measurement information includes: a second systolic pressure value and/or a second diastolic pressure value;
  • the calibration update module 64 is further configured to acquire a current blood pressure difference value of the first measured blood pressure information and the second blood pressure measurement information, and the current blood pressure difference value is greater than or equal to a preset blood pressure difference value, and When the current confidence is greater than or equal to the preset reliability, the calibration counter is incremented by 1, and when the calibration counter value is greater than or equal to a preset value, the first blood pressure measurement information is determined as the blood pressure measurement Blood pressure calibration information of the device, and clearing the calibration counter, and updating the historical calibration parameter list based on the first blood pressure measurement information and the current confidence.
  • the calibration update module 64 is specifically configured to:
  • the confidence calculation module 62 is specifically configured to:
  • Acquiring the current confidence level according to at least one of the following parameters: blood pressure input data of the blood pressure measuring device, signal quality of a physiological signal of the blood pressure measuring device, historical blood pressure input data of the blood pressure measuring device, or the Historical physiological signal data of blood pressure measuring devices.
  • the confidence calculation module 62 is specifically configured to:
  • the first confidence, the second confidence, and the third confidence are weighted and summed to obtain a current confidence of the first blood pressure measurement information.
  • the blood pressure measuring device can perform the technical solutions shown in the foregoing method embodiments, and the implementation principle and the beneficial effects thereof are similar, and details are not described herein.
  • FIG. 7 is a schematic structural diagram of a blood pressure measuring device according to an embodiment of the present invention.
  • the blood pressure measuring device provided by the embodiment of the present invention includes: a memory 71 and a processor 72.
  • the memory 71 is configured to store execution instructions
  • the processor 72 may be a central processing unit (CPU), or an application specific integrated circuit (ASIC), or one that implements an embodiment of the present invention. Or multiple integrated circuits.
  • the processor 72 is configured to call an execution instruction in the memory 71 and perform the following operations:
  • first blood pressure measurement information of the blood pressure measuring device Obtaining first blood pressure measurement information of the blood pressure measuring device and current confidence corresponding to the first blood pressure measurement information, the first blood pressure measurement information including a first systolic pressure value and/or a first diastolic pressure value;
  • the historical calibration parameter list including historical blood pressure calibration information and historical confidence corresponding to the historical blood pressure calibration information, the historical blood pressure calibration information including a historical contraction pressure value and / or historical diastolic pressure;
  • the blood pressure measuring device includes a historical calibration parameter list, and the current confidence is greater than or equal to a preset reliability, or greater than or equal to the historical confidence, determining the first blood pressure measurement information as the Blood pressure calibration information of the blood pressure measuring device, and updating the historical calibration parameter list based on the first blood pressure measurement information and the current confidence.
  • the blood pressure measuring device can perform the technical solutions shown in the foregoing method embodiments, and the implementation principle and the beneficial effects thereof are similar, and details are not described herein.
  • the processor 72 is specifically configured to:
  • the blood pressure measuring device does not include the historical calibration parameter list, acquiring a physiological signal of the blood pressure measuring device, the physiological signal comprising: a user's ECG signal and/or the user's pulse wave signal;
  • the second blood pressure measurement information comprising: Systolic pressure and/or second diastolic pressure;
  • the calibration counter is incremented by 1, and the calibration counter value is greater than or equal to the preset Numerical value, the first blood pressure measurement information is determined as blood pressure calibration information of the blood pressure measuring device, and the calibration counter is cleared, and the update is performed according to the first blood pressure measurement information and the current confidence level A list of historical calibration parameters.
  • processor 72 is specifically configured to:
  • processor 72 is specifically configured to:
  • Acquiring the current confidence level according to at least one of the following parameters: blood pressure input data of the blood pressure measuring device, signal quality of a physiological signal of the blood pressure measuring device, historical blood pressure input data of the blood pressure measuring device, or the Historical physiological signal data of blood pressure measuring devices.
  • processor 72 is specifically configured to:
  • the first confidence, the second confidence, and the third confidence are weighted and summed to obtain a current confidence of the first blood pressure measurement information.
  • the blood pressure measuring device can perform the technical solutions shown in the foregoing method embodiments, and the implementation principle and the beneficial effects thereof are similar, and details are not described herein.

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Abstract

一种血压测量设备的校准方法及血压测量设备,该方法包括:获取血压测量设备的第一血压测量信息(S401)、及第一血压测量信息对应的当前置信度(S402),第一血压测量信息包括第一收缩压值和/或第一舒张压值;判断血压测量设备中是否包括历史校准参数列表(S403),历史校准参数列表包括历史血压校准信息及历史血压校准信息对应的历史置信度;若血压测量设备中包括历史校准参数列表,且当前置信度大于或等于预设置信度、或大于或等于历史置信度时,将第一血压测量信息确定为血压测量设备的血压校准信息,并根据第一血压测量信息和当前置信度更新历史校准参数列表(S405)。该血压测量设备的校准方法及血压测量设备用于确保测量血压信息的准确度,且避免了借助额外设备来实现测量血压信息的校准。

Description

血压测量设备的校准方法及血压测量设备 技术领域
本发明涉及智能终端技术领域,尤其涉及一种血压测量设备的校准方法及血压测量设备。
背景技术
近年来,随着移动医疗技术的发展,血压监测的便捷性逐渐提升,国内外市场越来越重视家庭血压和动态血压的监测。因此,准确、便携的血压测量很有必要,是当前人们非常关注的重要课题。
目前,主要采用无袖带式血压测量装置测量用户的血压,其中,无袖带式血压测量装置利用脉搏波传输时间测量血压,无需使用袖带,能够为用户提供一种便捷和舒适的测量方式。由于每个人的动脉壁弹性、血液密度等生理参数不同,脉搏波传输时间与用户血压之间的关系是对象依赖的,因此,在测量用户的血压时,无袖带式血压测量装置会对每个用户的血压进行校准,以确保无袖带式血压测量装置测量血压的精确度。
然而,采用目前的无袖带式血压测量装置,在对每个用户的血压进行校准时,需要使用额外设备(比如袖带式血压计或标准血压计)测量标准血压,将测量的标准血压输入无袖带式血压测量装置以获得用户的真实血压,成本较高。
发明内容
本发明提供一种血压测量设备的校准方法及血压测量设备,可以确保测量血压信息的准确度,且避免了借助额外设备来实现测量血压信息的校准。
第一方面,本发明提供的血压测量设备的校准方法,包括:获取所述血压测量设备的第一血压测量信息、及所述第一血压测量信息对应的当前置信度,所述第一血压测量信息包括第一收缩压值和/或第一舒张压值;判断所述血压测量设备中是否包括历史校准参数列表,所述历史校准参数列表包括历史血压校准信息及所述历史血压校准信息对应的历史置信度,所述历史血 压校准信息包括历史收缩压值和/或历史舒张压值;若所述血压测量设备中包括历史校准参数列表,且所述当前置信度大于或等于预设置信度、或大于或等于所述历史置信度时,将所述第一血压测量信息确定为所述血压测量设备的血压校准信息,并根据所述第一血压测量信息和所述当前置信度更新所述历史校准参数列表。
通过将根据用户生理信号直接测量获得的第一测量血压信息作为校准信息,将无校准结果应用于手动校准测量中,既确保了测量的血压的准确度,也减少了用户采用额外设备自行校准的次数,且避免了借助额外设备来实现测量血压信息的校准,使得血压测量装置测量血压信息的成本降低,具有较高的便携性。
在一种可能的实施方式中,若所述血压测量设备中不包括历史校准参数列表,则获取血压测量设备的生理信号,生理信号包括:用户的心电信号和/或用户的脉搏波信号;当当前置信度小于历史置信度,根据历史血压校准信息和生理信号确定血压测量设备的第二血压测量信息,第二血压测量信息包括:第二收缩压值和/或第二舒张压值;获取所述第一测量血压信息与所述第二血压测量信息的当前血压差异值;若当前血压差异值大于或等于预设血压差异值,且当前置信度大于或等于预设置信度时,校准计数器加1,并在校准计数器数值大于或等于预设数值时,将所述第一血压测量信息确定为所述血压测量设备的血压校准信息,以及将校准计数器清零,并根据所述第一血压测量信息和所述当前置信度更新所述历史校准参数列表。
通过在第一测量血压的当前置信度小于历史血压校准信息的历史置信度时,判断第一测量血压与第二测量血压的差值是否大于预设血压值,且判断第一测量血压的当前置信度是否大于预设阈值,以确定采用无校准测量模块测量的第一测量血压的精确度是否大于校准测量模块测量的第二测量血压,从而确定第一测量血压作为校准信息的可用性。
在另一种可能的实施方式中,可以通过如下可行的实现方式获取所述第一测量血压信息与所述第二血压测量信息的当前血压差异值:
一种可行的实现方式:根据所述第一收缩压值与所述第二收缩压值,确定所述当前血压差异值;
另一种可行的实现方式:根据所述第一舒张压值与所述第二舒张压值, 确定所述当前血压差异值;
又一种可行的实现方式:根据所述第一收缩压值和所述第一舒张压值的比值、以及所述第二收缩压值和所述第二舒张压值的比值,确定所述当前血压差异值。
在另一种可能的实施方式中,获取所述第一血压测量信息对应的当前置信度,包括:根据如下参数中的至少一个参数获取所述当前置信度:所述血压测量设备的血压输入数据、所述血压测量设备的生理信号的信号质量、所述血压测量设备的历史血压输入数据或所述血压测量设备的历史生理信号数据。根据上述至少一个参数获取第一血压测量信息对应的当前置信度,从而可以更加准确的确定第一测量血压作为校准信息的可用性。
在另一种可能的实施方式中,获取第一血压测量信息对应的当前置信度,包括:根据生理信号的信号质量获取第一置信度;根据第一血压测量信息与历史血压校准信息的差异获取第二置信度;根据血压测量设备的血压输入数据与历史输入数据的相似度获取第三置信度;将第一置信度、第二置信度和第三置信度进行加权求和,得到第一血压测量信息的当前置信度。
通过根据血压输入数据、生理信号和第一测量血压计算第一测量血压的当前置信度的实现方式获取第一血压测量信息对应的当前置信度,从而确定第一测量血压作为校准信息的可用性。
第二方面,本发明提供的血压测量设备,包括第一获取模块、置信度计算模块、判断模块和校准更新模块,其中,
所述第一获取模块用于,获取所述血压测量设备的第一血压测量信息,所述第一血压测量信息包括第一收缩压值和/或第一舒张压值;
所述置信度计算模块用于,获取所述第一血压测量信息对应的当前置信度;
所述判断模块用于,判断所述血压测量设备中是否包括历史校准参数列表,所述历史校准参数列表中包括历史血压校准信息及所述历史血压校准信息对应的历史置信度,所述历史血压校准信息包括历史收缩压值和/或历史舒张压值;
所述校准更新模块用于,在所述判断模块判断所述血压测量设备中包括历史校准参数列表,且所述当前置信度大于或等于预设置信度、或大于或等 于所述历史置信度时,将所述第一血压测量信息确定为所述血压测量设备的血压校准信息,并根据所述第一血压测量信息和所述当前置信度更新所述历史校准参数列表。
本发明第二方面提供的血压测量设备用于执行第一方面方法实施例中的技术方案,其实现原理和技术效果类似,此处不再赘述。
在一种可能的实施方式中,所述血压测量设备还包括第二获取模块,其中,
所述第二获取模块用于,在所述判断模块判断所述血压测量设备中不包括历史校准参数列表时,获取所述血压测量设备的生理信号,所述生理信号包括:用户的心电信号和/或所述用户的脉搏波信号;
所述第一获取模块还用于,在所述当前置信度小于所述历史置信度时,根据所述历史血压校准信息和所述生理信号确定所述血压测量设备的第二血压测量信息,所述第二血压测量信息包括:第二收缩压值和/或第二舒张压值;
所述校准更新模块还用于,获取所述第一测量血压信息与所述第二血压测量信息的当前血压差异值,且在所述当前血压差异值大于或等于预设血压差异值,且所述当前置信度大于或等于所述预设置信度时,校准计数器加1,并在所述校准计数器数值大于或等于预设数值时,将所述第一血压测量信息确定为所述血压测量设备的血压校准信息,以及将所述校准计数器清零,并根据所述第一血压测量信息和所述当前置信度更新所述历史校准参数列表。
在另一种可能的实施方式中,所述校准更新模块具体用于:
根据所述第一收缩压值与所述第二收缩压值,确定所述当前血压差异值;
或者,根据所述第一舒张压值与所述第二舒张压值,确定所述当前血压差异值;
或者,根据所述第一收缩压值和所述第一舒张压值的比值、以及所述第二收缩压值和所述第二舒张压值的比值,确定所述当前血压差异值。
在另一种可能的实施方式中,所述置信度计算模块具体用于:
根据如下参数中的至少一个参数获取所述当前置信度:所述血压测量设备的血压输入数据、所述血压测量设备的生理信号的信号质量、所述血压测量设备的历史血压输入数据或所述血压测量设备的历史生理信号数据。
在另一种可能的实施方式中,所述置信度计算模块具体用于:
根据所述生理信号的信号质量获取第一置信度;
根据所述第一血压测量信息与历史血压校准信息的差异获取第二置信度;
根据所述血压测量设备的血压输入数据与历史输入数据的相似度获取第三置信度;
将所述第一置信度、所述第二置信度和所述第三置信度进行加权求和,得到所述第一血压测量信息的当前置信度。
本发明第二方面提供的血压测量设备用于执行第一方面方法实施例中的技术方案,其实现原理和技术效果类似,此处不再赘述。
第三方面,本发明实施例提供一种血压测量设备,包括:存储器和处理器,所述存储器用于存储执行指令,所述处理器用于调用所述存储器中的执行指令,并执行如下操作:
获取所述血压测量设备的第一血压测量信息、及所述第一血压测量信息对应的当前置信度,所述第一血压测量信息包括第一收缩压值和/或第一舒张压值;
判断所述血压测量设备中是否包括历史校准参数列表,所述历史校准参数列表包括历史血压校准信息及所述历史血压校准信息对应的历史置信度,所述历史血压校准信息包括历史收缩压值和/或历史舒张压值;
若所述血压测量设备中包括历史校准参数列表,且所述当前置信度大于或等于预设置信度、或大于或等于所述历史置信度时,将所述第一血压测量信息确定为所述血压测量设备的血压校准信息,并根据所述第一血压测量信息和所述当前置信度更新所述历史校准参数列表。
本发明第三方面提供的血压测量设备用于执行第一方面方法实施例中的技术方案,其实现原理和技术效果类似,此处不再赘述。
在一种可能的实施方式中,所述处理器具体用于:
若所述血压测量设备中不包括历史校准参数列表,则获取所述血压测量设备的生理信号,所述生理信号包括:用户的心电信号和/或所述用户的脉搏波信号;
当所述当前置信度小于所述历史置信度时,根据所述历史血压校准信息和所述生理信号确定所述血压测量设备的第二血压测量信息,所述第二血压 测量信息包括:第二收缩压值和/或第二舒张压值;
获取所述第一测量血压信息与所述第二血压测量信息的当前血压差异值;
若所述当前血压差异值大于或等于预设血压差异值,且所述当前置信度大于或等于所述预设置信度时,校准计数器加1,并在所述校准计数器数值大于或等于预设数值时,将所述第一血压测量信息确定为所述血压测量设备的血压校准信息,以及将所述校准计数器清零,并根据所述第一血压测量信息和所述当前置信度更新所述历史校准参数列表。
在另一种可能的实施方式中,所述处理器具体用于:
根据所述第一收缩压值与所述第二收缩压值,确定所述当前血压差异值;
或者,根据所述第一舒张压值与所述第二舒张压值,确定所述当前血压差异值;
或者,根据所述第一收缩压值和所述第一舒张压值的比值、以及所述第二收缩压值和所述第二舒张压值的比值,确定所述当前血压差异值。
在另一种可能的实施方式中,所述处理器具体用于:
根据如下参数中的至少一个参数获取所述当前置信度:所述血压测量设备的血压输入数据、所述血压测量设备的生理信号的信号质量、所述血压测量设备的历史血压输入数据或所述血压测量设备的历史生理信号数据。
在另一种可能的实施方式中,所述处理器具体用于:
根据所述生理信号的信号质量获取第一置信度;
根据所述第一血压测量信息与历史血压校准信息的差异获取第二置信度;
根据所述血压测量设备的血压输入数据与历史输入数据的相似度获取第三置信度;
将所述第一置信度、所述第二置信度和所述第三置信度进行加权求和,得到所述第一血压测量信息的当前置信度。
本发明第三方面提供的血压测量设备用于执行第一方面方法实施例中的技术方案,其实现原理和技术效果类似,此处不再赘述。
本发明实施例提供的血压测量设备的校准方法及血压测量设备,通过将根据用户生理信号直接测量获得的第一测量血压信息作为校准信息,将无校 准结果应用于手动校准测量中,既确保了测量的血压的准确度,也减少了用户采用额外设备自行校准的次数,且避免了借助额外设备来实现测量血压信息的校准,使得血压测量装置测量血压信息的成本降低,具有较高的便携性。
附图说明
为了更清楚地说明本发明实施例或现有技术中的技术方案,下面将对实施例或现有技术描述中所需要使用的附图作简单地介绍,显而易见地,下面描述中的附图仅仅是本发明的一些实施例,对于本领域普通技术人员来讲,在不付出创造性劳动性的前提下,还可以根据这些附图获得其他的附图。
图1为根据脉搏波信号测量用户血压的示意图;
图2为根据脉搏波信号和心电信号测量用户血压的示意图;
图3为根据脉搏波信号和心电信号获取PPT的示意图;
图4为本发明实施例提供的血压测量设备的校准方法的流程图;
图5为本发明实施例提供的计算第一测量血压信息的当前置信度的流程图;
图6为本发明实施例提供的血压测量设备的结构示意图;
图7为本发明实施例提供的血压测量设备的结构示意图。
具体实施方式
下面将结合本发明实施例中的附图,对本发明实施例中的技术方案进行清楚、完整地描述,显然,所描述的实施例仅仅是本发明一部分实施例,而不是全部的实施例。基于本发明中的实施例,本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例,都属于本发明保护的范围。
目前,测量血压的技术主要是根据获取用户(以下简称用户)的生理信号,以测量出用户的血压,其中,用户的生理信号包括:心电信号和/或脉搏波信号,心电信号是用户心脏在跳动时发出的;脉搏波信号是用户血液在血管内流动与血管相互作用形成的。图1为根据脉搏波信号测量用户血压的示意图,如图1所示,根据脉搏波信号采用光电容积脉搏波法分析获取血液在血管中流动的血流参数,光电容积脉搏波法是根据外周微血管的血液容积随心脏搏动而产生的脉动性变化,通过光电容积脉搏波 (Photoplethysmography,简称PPG)描记法获得的PPG信号,其中,PPG描记法是一种简单的、低成本的、可以用来探测组织血管中血量变化的光学测量技术。根据脉搏波信号测量血压的实现原理为将两个光电容积脉搏波传感器(如图1中PPG1和PPG2)分别安置于用户肱动脉(如图1中位置1)与中指指动脉(如图1中位置2)的皮肤上,通过测量肱动脉与中指指动脉的距离可以获得动脉两点之间的距离,也即获得脉搏波通过动脉两点之间的距离,通过测量脉搏波在位置1的时间点T1和在位置2的时间点T2,可以获得脉搏波的传递时间(Pulse Transit Time,PTT),根据动脉两点之间的距离和脉搏波的传递时间计算出脉搏波传播速度(Pulse Wave Velocity,PWV),根据PWV与血压的线性关系测量出用户的血压。
图2为根据脉搏波信号和心电信号测量用户血压的示意图,图3为根据脉搏波信号和心电信号获取PPT的示意图,如图2和图3所示,根据心电信号的参考点和同一心动周期内检测到的脉搏波信号上的参考点测量用户的血压。根据脉搏波信号和心电信号测量血压的实现原理为将光电容积脉搏波传感器安置于用户小拇指指动脉的皮肤上,将压力脉搏波传感器安置于用户手腕的皮肤上,通过测量用户小拇指指动脉(如图2中位置1)与手腕(如图2中位置2)的距离可以获得动脉两点之间的距离,通过测量脉搏波在位置1的时间点和心电信号在位置2的时间点,可以获得PTT,根据动脉两点之间的距离和PTT计算出PWV,根据PWV与血压的线性关系测量出用户的血压。
下面以具体地实施例对本发明的技术方案进行详细说明。下面这几个具体的实施例可以相互结合,对于相同或相似的概念或过程可能在某些实施例不再赘述。
图4为本发明实施例提供的血压测量设备的校准方法的流程图。如图4所示,本发明实施例提供的血压测量设备的校准方法,包括:
S401:获取血压测量设备的第一测量血压信息。
其中,第一血压测量信息包括:第一收缩压值和/或第一舒张压值,第一测量血压信息为待校准的血压信息。
具体的,本发明实施例提供的血压测量设备的校准方法可以用于血压测量设备的校准装置中,该血压测量设备的校准装置可以是手机和可穿戴设备等终端。本实施例中血压测量装置可以包括第一校准测量模块和第二校准测 量模块,第一校准测量模块为无校准测量模块,第二校准测量模块为校准测量模块,当用户需要测量血压时,用户可以通过输入用户个人信息(如身高、体重、年龄和性别)和采集一定时长的生理信号(30秒)来启用无校准测量模块,无校准测量模块可以采集用户的至少一种生理信号,比如心电信号和/或脉搏波信号,根据采集到的生理信号获取用户的第一测量血压信息,作为血压测量设备的第一测量血压信息。其中第一测量血压信息是根据用户的生理信号直接计算获得的用户的测量血压信息,没有经过任何校准信息校准过的血压,第一测量血压信息包括:用户的收缩压(Systolic pressure,简称SBP)、用户的舒张压(Diastolic pressure,简称DBP)和用户的脉搏波的传递时间(Pulse Transit Time,PTT),比如,若某次测量结果为SBP/DBP=112/72毫米汞柱(mmHg),这表示当前血压为收缩压112mmHg,舒张压72mmHg。
需要说明的是,本实施例中的心电信号可以通过光传感器、压力传感器、声传感器、光电传感器、加速度传感器或位移传感器来测量,脉搏波可以通过光电传感器采集光电容积描记信号来表征。无校准测量模块根据用户的生理信号获取用户的测量血压信息可以参见上述图1和图2中的描述,本实施例在此不进行限定和赘述。
需要说明的是,当用户需要测量血压时,用户可以通过输入用户个人信息(如身高、体重、年龄和性别)和采集一定时长的生理信号(30秒)来启用无校准测量模块时,可设置不同的用户账号,每个用户账号中保存有相对应用户的个人信息。对于注册过的用户,直接使用已有账号登陆即可,对于首次使用的用户需要注册新的账户名,以及用户在该账户名下输入用户的个人信息。用户输入账号名登录个人账号时,无校准测量模块可直接获取该账户名下存储的用户信息,以及确定该账户名下校准数据库中是否有历史血压校准信息。
S402:获取第一测量血压信息对应的当前置信度。
具体的,本发明实施例采用置信度对第一测量血压信息的准确度进行衡量,以确定无校准测量模块测量的第一测量血压信息作为校准信息的可用性。
可选的,可以根据如下参数中的至少一个参数获取当前置信度:血压测量设备的血压输入数据、血压测量设备的生理信号的信号质量、血压测量设备的历史血压输入数据或血压测量设备的历史生理信号数据。
具体的,本实施例中可以根据以下一种或其组合计算第一测量血压信息对应的当前置信度(可简称当前置信度):第一,根据无校准测量模块获取的外部用户血压输入数据确定第一测量血压信息的当前置信度,第二、根据校准测量模块获取的用户的历史血压输入数据确定第一测量血压信息的当前置信度,第三、无校准测量模块根据采集的用户的生理信号计算信号质量(比如信噪比、交直流占比、信号强度等),将信号质量映射为第一测量血压信息的当前置信度,第四、校准测量模块将用户的历史生理信号计算信号质量(比如信噪比、交直流占比、信号强度等),将信号质量映射为第一测量血压信息的当前置信度,第五、无校准测量模块直接提供的置信度作为第一测量血压信息的当前置信度,第六、根据血压输入数据、生理信号和第一测量血压信息计算第一测量血压信息的当前置信度。
可选的,获取第一血压测量信息对应的当前置信度,包括:根据生理信号的信号质量获取第一置信度Q1;根据第一测量血压信息与预设校准信息的差异获取第二置信度Q2;根据血压输入数据与历史输入数据的相似度获取第三置信度Q3;将第一置信度Q1、第二置信度Q2和第三置信度Q3进行加权求和,得到第一测量血压信息的当前置信度Q。
具体的,本实施例中根据血压输入数据、生理信号和第一测量血压信息三者共同计算第一测量血压信息对应的当前置信度(可简称当前置信度),图5为本发明实施例提供的计算第一测量血压信息的当前置信度的流程图,如图5所示,根据生理信号的信号质量获取第一置信度Q1,根据第一测量血压信息与历史血压校准信息的差异获取第二置信度Q2,根据血压输入数据与历史输入数据的相似度获取第三置信度Q3,第一置信度Q1、第二置信度Q2和第三置信度Q3采用公式
Figure PCTCN2016102947-appb-000001
计算得到第一测量血压信息的当前置信度Q。其中,加权权重ωi可以为固定的值,此时,
Figure PCTCN2016102947-appb-000002
也可以根据层次分析法计算得到,本实施在此不进行限定和赘述。需要说明的是,本实施例也可以将第一置信度Q1、第二置信度Q2和第三置信度Q3的算术平均值作为第一测量血压信息的当前置信度Q。
S403:判断血压测量设备中是否包括历史校准参数列表。若血压测量设备中不包括历史校准参数列表,则执行S404;若血压测量设备中包括历史校准参数列表,执行S406。
其中,历史校准参数列表中包括历史血压校准信息及历史血压校准信息对应的历史置信度,历史血压校准信息包括历史收缩压值和/或历史舒张压值
具体的,本实施例中通过判断血压测量设备中是否包括历史校准参数列表,以确定用户血压测量设备的校准是有历史校准的场景还是无历史校准的场景,以确定后续步骤中如何设置血压测量设备的校准信息,以及如何更新血压测量设备的校准信息。其中,历史血压校准信息可以包括:SBP、DBP和PTT,该历史血压校准信息可以来自用户的输入的自身真实的血压数据,此时历史血压校准信息的历史置信度为1,历史血压校准信息也可以来自无校准测量模块测量的第一测量血压信息,此时历史血压校准信息的历史置信度为第一测量血压信息的当前置信度。
需要说明的是,S402和S403的顺序可以互换,也可以先执行S403,后执行S402,本实施例在此不进行限定和赘述。
S404:判断第一测量血压信息的当前置信度是否大于或等于预设置信度。若第一测量血压信息的当前置信度大于或等于预设置信度,则执行S405;否则,结束。
具体的,当S403中检测到校准信息库中没有历史血压校准信息时,本实施例可以直接采用第一测量血压信息作为校准信息进行校准。在将第一测量血压信息作为校准信息进行校准前,需要对第一测量血压信息的当前置信度进行判断,以确定将无校准测量模块测量的第一测量血压信息作为校准信息的可用性。
S405:将第一血压测量信息确定为血压量设备的血压校准信息,并根据第一血压测量信息和当前置信度更新历史校准参数列表。
具体的,当S403中检测到校准信息库中没有历史血压校准信息时,若第一测量血压信息的当前置信度大于或等于预设置信度,其中预设置信度可以为90%,则第一测量血压信息的当前置信度高,第一测量血压信息与用户的实际血压的误差较小,无校准测量模块测量的血压的准确度较高,此时第一测量血压信息可以作为血压校准信息,也即,校准测量模块可以根据第一测量血压信息和采集的用户生理信号计算血压,具体可以为采用第一测量血压信息,对根据用户生理信号获取的测量血压信息进行校准,以输出与用户的实际血压相匹配的测量血压信息,并据第一血压测量信息和当前置信度更新 历史校准参数列表,由于S403中检测到没有历史校准信息,即不包括历史列表,可以理解,此处所说的更新历史校准参数列表,也即建立历史校准参数列表。当S403中检测到校准信息库中没有历史血压校准信息时,若第一测量血压信息的当前置信度小于预设置信度,则结束,不作后续处理。
S406:获取血压测量设备的历史校准参数列表。
S407:判断第一测量血压信息的当前置信度是否大于或等于历史置信度。若第一测量血压信息的当前置信度大于或等于历史置信度,则执行S408;否则,执行S409。
具体的,在S406和S407中,当S403中检测到校准信息库中有历史血压校准信息时,获取血压测量设备的历史血压校准信息以及历史校准参数列表,并判断第一测量血压信息的当前置信度是否大于或等于历史校准参数列表中历史血压校准信息对应的历史置信度,以确定是否可以将第一测量血压信息作为校准信息,采用第一测量血压信息进行校准。
S408:将第一血压测量信息确定为血压测量设备的血压校准信息,并根据第一血压测量信息和当前置信度更新历史校准参数列表。
具体的,当S403中检测到校准信息库中有历史血压校准信息,且第一测量血压信息的当前置信度大于或等于历史血压校准信息对应的历史置信度,则第一测量血压信息的当前置信度高,第一测量血压信息与用户的实际血压的误差较小,无校准测量模块测量的血压的准确度较高,此时第一测量血压信息可以作为血压校准信息,也即,校准测量模块可以根据第一测量血压信息和采集的用户生理信号计算血压,具体可以为采用第一测量血压信息,对根据用户生理信号获取的测量血压信息进行校准,以输出与用户的实际血压相匹配的测量血压信息,并根据第一血压测量信息和当前置信度更新历史校准参数列表。
S409:根据历史血压校准信息和生理信号确定血压测量设备的第二血压测量信息。
其中,第二血压测量信息包括:第二收缩压值和/或第二舒张压值。
进一步地,在步骤S401获取血压测量设备的第一测量血压信息的同时,获取血压测量设备的生理信号,生理信号包括:用户的心电信号和/或用户的脉搏波信号。
具体的,当S403中检测到校准信息库中有历史血压校准信息,且第一测量血压信息的当前置信度小于历史信度阈值时,本实施例根据历史血压校准信息和生理信号确定血压测量设备的第二血压测量信息,具体为,采用历史血压校准信息对根据生理信号获取的用户的测量血压校准后,得到第二测量血压信息。
S410:获第一测量血压信息与第二血压测量信息的当前血压差异值。
具体的,可以根据第一收缩压值与第二收缩压值的当前血压差异值确定第一测量血压信息与第二测量血压信息的当前血压差异值,也可以根据第一舒张压值与第二舒张压值的当前血压差异值确定第一测量血压信息与第二测量血压信息的当前血压差异值,也可以根据第一收缩压值和第一舒张压值的比值、以及第二收缩压值和第二舒张压值的比值,确定第一测量血压信息与第二测量血压信息的当前血压差异值。
通过确定第一测量血压信息与第二测量血压信息的当前血压差异值,以确定是否可以将第一测量血压信息作为校准信息,采用第一测量血压信息进行校准。
S411:判断当前血压差异值是否大于预设血压差异值,且判断第一测量血压信息的当前置信度是否大于预设置信度。若当前血压差异值大于或等于预设血压差异值,且第一测量血压信息的当前置信度大于或等于预设置信度,则执行S412;否则,结束。
具体的,当S403中检测到校准信息库中有历史血压校准信息,且第一测量血压信息的当前置信度小于历史血压校准信息的历史置信度时,判断第一测量血压信息与第二测量血压信息的差值是否大于预设血压值,且判断第一测量血压信息的当前置信度是否大于预设置信度,以确定采用无校准测量模块测量的第一测量血压信息的精确度是否大于校准测量模块测量的第二测量血压信息,从而确定第一测量血压信息作为校准信息的可用性。
S412:校准计数器加1。
具体的,本发明实施例还可以设置有校准计数器,当S410中判断第一测量血压信息与第二测量血压信息的差值大于预设血压值,且判断第一测量血压信息的当前置信度大于预设置信度时,校准计数器加1。
S413:判断校准计数器数值是否大于或等于预设数值。若校准计数器数 值大于或等于预设数值,则执行S414;否则,结束。
具体的,本实施例通过将校准计数器数值与预设数值进行比较,其中,预设数值例如可以为3、4、5等,本实施例中例如为5,以进一步确定第一测量血压信息作为校准信息的可用性。
S414:将第一血压测量信息确定为血压测量设备的血压校准信息,以及将校准计数器清零,并根据第一血压测量信息和当前置信度更新历史校准参数列表。
具体的,当S413中判断校准计数器数值大于或等于预设数值时,第一测量血压信息的精确度还是比较高的,可以采用第一测量血压信息对用户的测量血压信息进行校准,并将历史血压校准信息更新为第一测量血压信息,将历史血压校准信息的历史置信度更新为第一测量血压信息的当前置信度,以及将校准计数器清零,实现校准数据库的更新以及校准计数器的更新。
本发明实施例提供的血压测量设备的校准方法,通过将根据用户生理信号直接测量获得的第一测量血压信息作为校准信息,将无校准结果应用于手动校准测量中,既确保了测量的血压的准确度,也减少了用户采用额外设备自行校准的次数,且避免了借助额外设备来实现测量血压信息的校准,使得血压测量装置测量血压信息的成本降低,具有较高的便携性;同时,通过判断校准信息库中是否有历史血压校准信息,采用两种不同的算法确定第一测量血压信息作为校准信息的可用性,以及当校准信息库中有历史血压校准信息时,将历史血压校准信息更新为第一测量血压信息,使得更新后的历史血压校准信息尽可能与用户的实际血压相匹配,进一步确保测量血压信息的准确度。通过在第一测量血压的当前置信度小于历史血压校准信息的历史置信度时,判断第一测量血压与第二测量血压的差值是否大于预设血压值,且判断第一测量血压的当前置信度是否大于预设阈值,以确定采用无校准测量模块测量的第一测量血压的精确度是否大于校准测量模块测量的第二测量血压,从而确定第一测量血压作为校准信息的可用性。
图6为本发明实施例提供的血压测量设备的结构示意图。如图6所示,包括第一获取模块61、置信度计算模块62、判断模块63和校准更新模块64,其中,
所述第一获取模块61用于,获取所述血压测量设备的第一血压测量信 息,所述第一血压测量信息包括第一收缩压值和/或第一舒张压值;
所述置信度计算模块62用于,获取所述第一血压测量信息对应的当前置信度;
所述判断模块63用于,判断所述血压测量设备中是否包括历史校准参数列表,所述历史校准参数列表中包括历史血压校准信息及所述历史血压校准信息对应的历史置信度,所述历史血压校准信息包括历史收缩压值和/或历史舒张压值;
所述校准更新模块64用于,在所述判断模块63判断所述血压测量设备中包括历史校准参数列表,且所述当前置信度大于或等于预设置信度、或大于或等于所述历史置信度时,将所述第一血压测量信息确定为所述血压测量设备的血压校准信息,并根据所述第一血压测量信息和所述当前置信度更新所述历史校准参数列表。
本发明实施例所述的血压测量设备可以执行上述方法实施例所示的技术方案,其实现原理以及有益效果类似,此处不再进行赘述。
在一种可能的实施方式中,所述血压测量设备还包括第二获取模块65,其中,
所述第二获取模块65用于,在所述判断模块63判断所述血压测量设备中不包括历史校准参数列表时,获取所述血压测量设备的生理信号,所述生理信号包括:用户的心电信号和/或所述用户的脉搏波信号;
所述第一获取模块61还用于,在所述当前置信度小于所述历史置信度时,根据所述历史血压校准信息和所述生理信号确定所述血压测量设备的第二血压测量信息,所述第二血压测量信息包括:第二收缩压值和/或第二舒张压值;
所述校准更新模块64还用于,获取所述第一测量血压信息与所述第二血压测量信息的当前血压差异值,且在所述当前血压差异值大于或等于预设血压差异值,且所述当前置信度大于或等于所述预设置信度时,校准计数器加1,并在所述校准计数器数值大于或等于预设数值时,将所述第一血压测量信息确定为所述血压测量设备的血压校准信息,以及将所述校准计数器清零,并根据所述第一血压测量信息和所述当前置信度更新所述历史校准参数列表。
在另一种可能的实施方式中,所述校准更新模块64具体用于:
根据所述第一收缩压值与所述第二收缩压值,确定所述当前血压差异值;
或者,根据所述第一舒张压值与所述第二舒张压值,确定所述当前血压差异值;
或者,根据所述第一收缩压值和所述第一舒张压值的比值、以及所述第二收缩压值和所述第二舒张压值的比值,确定所述当前血压差异值。
在另一种可能的实施方式中,所述置信度计算模块62具体用于:
根据如下参数中的至少一个参数获取所述当前置信度:所述血压测量设备的血压输入数据、所述血压测量设备的生理信号的信号质量、所述血压测量设备的历史血压输入数据或所述血压测量设备的历史生理信号数据。
在另一种可能的实施方式中,所述置信度计算模块62具体用于:
根据所述生理信号的信号质量获取第一置信度;
根据所述第一血压测量信息与历史血压校准信息的差异获取第二置信度;
根据所述血压测量设备的血压输入数据与历史输入数据的相似度获取第三置信度;
将所述第一置信度、所述第二置信度和所述第三置信度进行加权求和,得到所述第一血压测量信息的当前置信度。
本发明实施例所述的血压测量设备可以执行上述方法实施例所示的技术方案,其实现原理以及有益效果类似,此处不再进行赘述。
图7为本发明实施例提供的血压测量设备的结构示意图。如图7所示,本发明实施例提供的血压测量设备,包括:存储器71和处理器72。
具体的,存储器71用于存储执行指令,处理器72可以是一个中央72(Central Processing Unit,CPU),或者是特定集成电路(Application Specific Integrated Circuit,ASIC),或者完成实施本发明实施例的一个或多个集成电路。处理器72用于调用存储器71中的执行指令,并执行以下操作:
获取所述血压测量设备的第一血压测量信息、及所述第一血压测量信息对应的当前置信度,所述第一血压测量信息包括第一收缩压值和/或第一舒张压值;
判断所述血压测量设备中是否包括历史校准参数列表,所述历史校准参数列表包括历史血压校准信息及所述历史血压校准信息对应的历史置信度,所述历史血压校准信息包括历史收缩压值和/或历史舒张压值;
若所述血压测量设备中包括历史校准参数列表,且所述当前置信度大于或等于预设置信度、或大于或等于所述历史置信度时,将所述第一血压测量信息确定为所述血压测量设备的血压校准信息,并根据所述第一血压测量信息和所述当前置信度更新所述历史校准参数列表。
本发明实施例所述的血压测量设备可以执行上述方法实施例所示的技术方案,其实现原理以及有益效果类似,此处不再进行赘述。
在一种可能的实施方式中,所述处理器72具体用于:
若所述血压测量设备中不包括历史校准参数列表,则获取所述血压测量设备的生理信号,所述生理信号包括:用户的心电信号和/或所述用户的脉搏波信号;
当所述当前置信度小于所述历史置信度时,根据所述历史血压校准信息和所述生理信号确定所述血压测量设备的第二血压测量信息,所述第二血压测量信息包括:第二收缩压值和/或第二舒张压值;
获取所述第一测量血压信息与所述第二血压测量信息的当前血压差异值;
若所述当前血压差异值大于或等于预设血压差异值,且所述当前置信度大于或等于所述预设置信度时,校准计数器加1,并在所述校准计数器数值大于或等于预设数值时,将所述第一血压测量信息确定为所述血压测量设备的血压校准信息,以及将所述校准计数器清零,并根据所述第一血压测量信息和所述当前置信度更新所述历史校准参数列表。
在另一种可能的实施方式中,所述处理器72具体用于:
根据所述第一收缩压值与所述第二收缩压值,确定所述当前血压差异值;
或者,根据所述第一舒张压值与所述第二舒张压值,确定所述当前血压差异值;
或者,根据所述第一收缩压值和所述第一舒张压值的比值、以及所述第二收缩压值和所述第二舒张压值的比值,确定所述当前血压差异值。
在另一种可能的实施方式中,所述处理器72具体用于:
根据如下参数中的至少一个参数获取所述当前置信度:所述血压测量设备的血压输入数据、所述血压测量设备的生理信号的信号质量、所述血压测量设备的历史血压输入数据或所述血压测量设备的历史生理信号数据。
在另一种可能的实施方式中,所述处理器72具体用于:
根据所述生理信号的信号质量获取第一置信度;
根据所述第一血压测量信息与历史血压校准信息的差异获取第二置信度;
根据所述血压测量设备的血压输入数据与历史输入数据的相似度获取第三置信度;
将所述第一置信度、所述第二置信度和所述第三置信度进行加权求和,得到所述第一血压测量信息的当前置信度。
本发明实施例所述的血压测量设备可以执行上述方法实施例所示的技术方案,其实现原理以及有益效果类似,此处不再进行赘述。
最后应说明的是:以上各实施例仅用以说明本发明的技术方案,而非对其限制;尽管参照前述各实施例对本发明进行了详细的说明,本领域的普通技术人员应当理解:其依然可以对前述各实施例所记载的技术方案进行修改,或者对其中部分或者全部技术特征进行等同替换;而这些修改或者替换,并不使对应技术方案的本质脱离本发明各实施例技术方案的范围。

Claims (15)

  1. 一种血压测量设备的校准方法,其特征在于,包括:
    获取所述血压测量设备的第一血压测量信息、及所述第一血压测量信息对应的当前置信度,所述第一血压测量信息包括第一收缩压值和/或第一舒张压值;
    判断所述血压测量设备中是否包括历史校准参数列表,所述历史校准参数列表包括历史血压校准信息及所述历史血压校准信息对应的历史置信度,所述历史血压校准信息包括历史收缩压值和/或历史舒张压值;
    若所述血压测量设备中包括历史校准参数列表,且所述当前置信度大于或等于预设置信度、或大于或等于所述历史置信度时,将所述第一血压测量信息确定为所述血压测量设备的血压校准信息,并根据所述第一血压测量信息和所述当前置信度更新所述历史校准参数列表。
  2. 根据权利要求1所述的方法,其特征在于,所述方法还包括:
    若所述血压测量设备中不包括历史校准参数列表,则获取所述血压测量设备的生理信号,所述生理信号包括:用户的心电信号和/或所述用户的脉搏波信号;
    当所述当前置信度小于所述历史置信度时,根据所述历史血压校准信息和所述生理信号确定所述血压测量设备的第二血压测量信息,所述第二血压测量信息包括:第二收缩压值和/或第二舒张压值;
    获取所述第一测量血压信息与所述第二血压测量信息的当前血压差异值;
    若所述当前血压差异值大于或等于预设血压差异值,且所述当前置信度大于或等于所述预设置信度时,校准计数器加1,并在所述校准计数器数值大于或等于预设数值时,将所述第一血压测量信息确定为所述血压测量设备的血压校准信息,以及将所述校准计数器清零,并根据所述第一血压测量信息和所述当前置信度更新所述历史校准参数列表。
  3. 根据权利要求2所述的方法,其特征在于,获取所述第一测量血压信息与所述第二血压测量信息的当前血压差异值,包括:
    根据所述第一收缩压值与所述第二收缩压值,确定所述当前血压差异值;
    或者,根据所述第一舒张压值与所述第二舒张压值,确定所述当前血压 差异值;
    或者,根据所述第一收缩压值和所述第一舒张压值的比值、以及所述第二收缩压值和所述第二舒张压值的比值,确定所述当前血压差异值。
  4. 根据权利要求2或3所述的方法,其特征在于,所述获取所述第一血压测量信息对应的当前置信度,包括:
    根据如下参数中的至少一个参数获取所述当前置信度:所述血压测量设备的血压输入数据、所述血压测量设备的生理信号的信号质量、所述血压测量设备的历史血压输入数据或所述血压测量设备的历史生理信号数据。
  5. 根据权利要求2或3所述的方法,其特征在于,所述获取所述第一血压测量信息对应的当前置信度,包括:
    根据所述生理信号的信号质量获取第一置信度;
    根据所述第一血压测量信息与所述历史血压校准信息的差异获取第二置信度;
    根据所述血压测量设备的血压输入数据与历史输入数据的相似度获取第三置信度;
    将所述第一置信度、所述第二置信度和所述第三置信度进行加权求和,得到所述第一血压测量信息的当前置信度。
  6. 一种血压测量设备,其特征在于,包括第一获取模块、置信度计算模块、判断模块和校准更新模块,其中,
    所述第一获取模块用于,获取所述血压测量设备的第一血压测量信息,所述第一血压测量信息包括第一收缩压值和/或第一舒张压值;
    所述置信度计算模块用于,获取所述第一血压测量信息对应的当前置信度;
    所述判断模块用于,判断所述血压测量设备中是否包括历史校准参数列表,所述历史校准参数列表中包括历史血压校准信息及所述历史血压校准信息对应的历史置信度,所述历史血压校准信息包括历史收缩压值和/或历史舒张压值;
    所述校准更新模块用于,在所述判断模块判断所述血压测量设备中包括历史校准参数列表,且所述当前置信度大于或等于预设置信度、或大于或等于所述历史置信度时,将所述第一血压测量信息确定为所述血压测量设备的 血压校准信息,并根据所述第一血压测量信息和所述当前置信度更新所述历史校准参数列表。
  7. 根据权利要求6所述的设备,其特征在于,所述血压测量设备还包括第二获取模块,其中,
    所述第二获取模块用于,在所述判断模块判断所述血压测量设备中不包括历史校准参数列表时,获取所述血压测量设备的生理信号,所述生理信号包括:用户的心电信号和/或所述用户的脉搏波信号;
    所述第一获取模块还用于,在所述当前置信度小于所述历史置信度时,根据所述历史血压校准信息和所述生理信号确定所述血压测量设备的第二血压测量信息,所述第二血压测量信息包括:第二收缩压值和/或第二舒张压值;
    所述校准更新模块还用于,获取所述第一测量血压信息与所述第二血压测量信息的当前血压差异值,且在所述当前血压差异值大于或等于预设血压差异值,且所述当前置信度大于或等于所述预设置信度时,校准计数器加1,并在所述校准计数器数值大于或等于预设数值时,将所述第一血压测量信息确定为所述血压测量设备的血压校准信息,以及将所述校准计数器清零,并根据所述第一血压测量信息和所述当前置信度更新所述历史校准参数列表。
  8. 根据权利要求7所述的设备,其特征在于,所述校准更新模块具体用于:
    根据所述第一收缩压值与所述第二收缩压值,确定所述当前血压差异值;
    或者,
    根据所述第一舒张压值与所述第二舒张压值,确定所述当前血压差异值;
    或者,
    根据所述第一收缩压值和所述第一舒张压值的比值、以及所述第二收缩压值和所述第二舒张压值的比值,确定所述当前血压差异值。
  9. 根据权利要求7或8所述的设备,其特征在于,所述置信度计算模块具体用于:
    根据如下参数中的至少一个参数获取所述当前置信度:所述血压测量设备的血压输入数据、所述血压测量设备的生理信号的信号质量、所述血压测量设备的历史血压输入数据或所述血压测量设备的历史生理信号数据。
  10. 根据权利要求7或8所述的设备,其特征在于,所述置信度计算模 块具体用于:
    根据所述生理信号的信号质量获取第一置信度;
    根据所述第一血压测量信息与所述历史血压校准信息的差异获取第二置信度;
    根据所述血压测量设备的血压输入数据与历史输入数据的相似度获取第三置信度;
    将所述第一置信度、所述第二置信度和所述第三置信度进行加权求和,得到所述第一血压测量信息的当前置信度。
  11. 一种血压测量设备,其特征在于,包括:存储器和处理器,所述存储器用于存储执行指令,所述处理器用于调用所述存储器中的执行指令,并执行如下操作:
    获取所述血压测量设备的第一血压测量信息、及所述第一血压测量信息对应的当前置信度,所述第一血压测量信息包括第一收缩压值和/或第一舒张压值;
    判断所述血压测量设备中是否包括历史校准参数列表,所述历史校准参数列表包括历史血压校准信息及所述历史血压校准信息对应的历史置信度,所述历史血压校准信息包括历史收缩压值和/或历史舒张压值;
    若所述血压测量设备中包括历史校准参数列表,且所述当前置信度大于或等于预设置信度、或大于或等于所述历史置信度时,将所述第一血压测量信息确定为所述血压测量设备的血压校准信息,并根据所述第一血压测量信息和所述当前置信度更新所述历史校准参数列表。
  12. 根据权利要求11所述的设备,其特征在于,所述处理器具体用于:
    若所述血压测量设备中不包括历史校准参数列表,则获取所述血压测量设备的生理信号,所述生理信号包括:用户的心电信号和/或所述用户的脉搏波信号;
    当所述当前置信度小于所述历史置信度时,根据所述历史血压校准信息和所述生理信号确定所述血压测量设备的第二血压测量信息,所述第二血压测量信息包括:第二收缩压值和/或第二舒张压值;
    获取所述第一测量血压信息与所述第二血压测量信息的当前血压差异值;
    若所述当前血压差异值大于或等于预设血压差异值,且所述当前置信度大于或等于所述预设置信度时,校准计数器加1,并在所述校准计数器数值大于或等于预设数值时,将所述第一血压测量信息确定为所述血压测量设备的血压校准信息,以及将所述校准计数器清零,并根据所述第一血压测量信息和所述当前置信度更新所述历史校准参数列表。
  13. 根据权利要求12所述的设备,其特征在于,所述处理器具体用于:
    根据所述第一收缩压值与所述第二收缩压值,确定所述当前血压差异值;
    或者,
    根据所述第一舒张压值与所述第二舒张压值,确定所述当前血压差异值;
    或者,
    根据所述第一收缩压值和所述第一舒张压值的比值、以及所述第二收缩压值和所述第二舒张压值的比值,确定所述当前血压差异值。
  14. 根据权利要求12或13所述的设备,其特征在于,所述处理器具体用于:
    根据如下参数中的至少一个参数获取所述当前置信度:所述血压测量设备的血压输入数据、所述血压测量设备的生理信号的信号质量、所述血压测量设备的历史血压输入数据或所述血压测量设备的历史生理信号数据。
  15. 根据权利要求12或13所述的设备,其特征在于,所述处理器具体用于:
    根据所述生理信号的信号质量获取第一置信度;
    根据所述第一血压测量信息与所述历史血压校准信息的差异获取第二置信度;
    根据所述血压测量设备的血压输入数据与历史输入数据的相似度获取第三置信度;
    将所述第一置信度、所述第二置信度和所述第三置信度进行加权求和,得到所述第一血压测量信息的当前置信度。
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Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10993627B1 (en) * 2017-01-24 2021-05-04 James Eric Dotter Device for determining blood pressure without a cuff
CN109406461B (zh) * 2018-09-30 2021-05-14 山东泰利信医疗科技有限公司 血小板聚集率测量结果判定方法及血小板聚集仪的标定方法
US20200237240A1 (en) * 2019-01-28 2020-07-30 Mediatek Inc. Vital-sign estimation apparatus and calibration method for vital-sign estimator
WO2020168528A1 (zh) * 2019-02-22 2020-08-27 吴宇 体征参数检测系统、体征参数的可靠性评价方法
CN110353650B (zh) * 2019-07-18 2022-05-03 北京合众思壮时空物联科技有限公司 基于ppg信号的特征波形提取系统
US20210290085A1 (en) * 2020-03-18 2021-09-23 Pixart Imaging Inc. Optical medical detection device
CN111398523B (zh) * 2020-03-30 2022-08-02 清华-伯克利深圳学院筹备办公室 基于分布的传感器数据校准方法及系统
CN113520357B (zh) * 2020-04-17 2023-04-28 华为技术有限公司 一种血压测量装置及方法
CN114469125B (zh) * 2022-02-17 2024-04-05 浙江荣泰健康电器有限公司 心电校准系统、方法、设备及存储介质
CN117694852A (zh) * 2023-05-26 2024-03-15 荣耀终端有限公司 血压测量方法及装置
CN117122770B (zh) * 2023-08-28 2024-03-08 北京中普达技术有限公司 一种基于智能手环及输液数据的监测呼叫系统

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1237885A (zh) * 1996-10-11 1999-12-08 迪克斯泰克公司 血压的非侵入性无套测定
US20080188733A1 (en) * 2006-12-22 2008-08-07 Ammar Al-Ali Physiological parameter system
CN101365376A (zh) * 2006-02-01 2009-02-11 阿斯卡拉波股份有限公司 用于采集生理测量数据的方法和装置
CN101366627A (zh) * 2008-09-26 2009-02-18 鲁东大学 一种能提示血压测量结果可信度的电子血压计
CN102655814A (zh) * 2009-12-18 2012-09-05 皇家飞利浦电子股份有限公司 用于心音图信号的信号处理设备和方法
US20150057554A1 (en) * 2013-08-23 2015-02-26 Covidien Lp Systems and methods for monitoring blood pressure
CN105342592A (zh) * 2015-11-27 2016-02-24 江苏鹿得医疗电子股份有限公司 一种可自动校零和满度的电子血压计

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4397317A (en) * 1980-04-17 1983-08-09 Villa Real Antony Euclid C Electronic blood pressure and pulse rate calculator with optional temperature indicator, timer and memory
US7455643B1 (en) * 2003-07-07 2008-11-25 Nellcor Puritan Bennett Ireland Continuous non-invasive blood pressure measurement apparatus and methods providing automatic recalibration
US8313439B2 (en) 2009-03-20 2012-11-20 Massachusetts Institute Of Technology Calibration of pulse transit time measurements to arterial blood pressure using external arterial pressure applied along the pulse transit path
US9198582B2 (en) 2009-06-30 2015-12-01 Nellcor Puritan Bennett Ireland Determining a characteristic physiological parameter
US20110184268A1 (en) * 2010-01-22 2011-07-28 Abbott Diabetes Care Inc. Method, Device and System for Providing Analyte Sensor Calibration
US9408542B1 (en) 2010-07-22 2016-08-09 Masimo Corporation Non-invasive blood pressure measurement system
US20120029363A1 (en) * 2010-07-30 2012-02-02 Nellcor Puritan Bennett Llc Systems and methods for improved computation of differential pulse transit time from photoplethysmograph signals
US20120136261A1 (en) * 2010-11-30 2012-05-31 Nellcor Puritan Bennett Llc Systems and methods for calibrating physiological signals with multiple techniques
US8825428B2 (en) * 2010-11-30 2014-09-02 Neilcor Puritan Bennett Ireland Methods and systems for recalibrating a blood pressure monitor with memory
US20120238846A1 (en) * 2011-03-18 2012-09-20 Hutchinson Technology Incorporated Vascular occlusion test apparatus, systems, and methods for analyzing tissue oxygenation
EP3013214B1 (en) * 2013-06-24 2021-04-21 Koninklijke Philips N.V. Early confirmation of a prolonged aperiodic measurement
US10765331B2 (en) * 2015-04-02 2020-09-08 Microsoft Technology Licensing, Llc Wearable pulse sensing device signal quality estimation
KR102486700B1 (ko) * 2015-08-11 2023-01-11 삼성전자주식회사 혈압 추정 방법 및 장치

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1237885A (zh) * 1996-10-11 1999-12-08 迪克斯泰克公司 血压的非侵入性无套测定
CN101365376A (zh) * 2006-02-01 2009-02-11 阿斯卡拉波股份有限公司 用于采集生理测量数据的方法和装置
US20080188733A1 (en) * 2006-12-22 2008-08-07 Ammar Al-Ali Physiological parameter system
CN101366627A (zh) * 2008-09-26 2009-02-18 鲁东大学 一种能提示血压测量结果可信度的电子血压计
CN102655814A (zh) * 2009-12-18 2012-09-05 皇家飞利浦电子股份有限公司 用于心音图信号的信号处理设备和方法
US20150057554A1 (en) * 2013-08-23 2015-02-26 Covidien Lp Systems and methods for monitoring blood pressure
CN105342592A (zh) * 2015-11-27 2016-02-24 江苏鹿得医疗电子股份有限公司 一种可自动校零和满度的电子血压计

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP3524137A4 *

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