WO2018056750A1 - Composition de matière cosmétique de type huile dans l'eau comprenant un sel inorganique et son procédé de préparation - Google Patents

Composition de matière cosmétique de type huile dans l'eau comprenant un sel inorganique et son procédé de préparation Download PDF

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WO2018056750A1
WO2018056750A1 PCT/KR2017/010471 KR2017010471W WO2018056750A1 WO 2018056750 A1 WO2018056750 A1 WO 2018056750A1 KR 2017010471 W KR2017010471 W KR 2017010471W WO 2018056750 A1 WO2018056750 A1 WO 2018056750A1
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피봉수
남진
안순애
이존환
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(주)아모레퍼시픽
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/06—Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/06—Emulsions
    • A61K8/062—Oil-in-water emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • A61K8/8152—Homopolymers or copolymers of esters, e.g. (meth)acrylic acid esters; Compositions of derivatives of such polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/89—Polysiloxanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/60—Particulates further characterized by their structure or composition
    • A61K2800/61—Surface treated
    • A61K2800/62—Coated
    • A61K2800/624—Coated by macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/60—Particulates further characterized by their structure or composition
    • A61K2800/65—Characterized by the composition of the particulate/core
    • A61K2800/654—The particulate/core comprising macromolecular material

Definitions

  • the present specification relates to an oil-in-water cosmetic composition containing an inorganic salt and a preparation method thereof.
  • An emulsified cosmetic formulation can impart moisturizing power to the skin with a flexible feel.
  • Surfactants usually used for emulsification show a dynamic emulsification state that circulates through the emulsification interface of the emulsified particles after emulsification formation.
  • the oil-in-water type emulsion formulation in which the inner phase is oil phase and the outer phase is water phase is a formulation that can provide moisturizing power through the inner phase while showing a fresh feeling by the characteristics of the outer phase.
  • the inorganic salt added to the aqueous phase is included in the emulsion particles in the case of the water-in-oil type in which the aqueous phase is an inner phase, thus acting as an emulsion stabilizer.
  • the inorganic salt included in the outer phase may affect the emulsification interface of the emulsified particles, thereby greatly inhibiting the emulsion stability.
  • the application possibilities are expanded.
  • One such application is a pickling emulsion that can form stabilized large emulsified particles using fine spherical particles.
  • the contact angle ⁇ is different between the aqueous phase and the oil phase.
  • O / W emulsified particles are formed at a contact angle of 90 ° or more, and W / O emulsified particles are formed at 90 ° or less.
  • the problem to be solved by the present invention is to provide an oil-in-water emulsion cosmetics excellent in emulsion stability including inorganic salts.
  • the problem to be solved by the present invention is to provide an oil-in-water emulsion cosmetic having excellent emulsion stability while containing a high content of inorganic salts.
  • the problem to be solved by the present invention is to provide an oil-in-water emulsion cosmetic of light usability.
  • the problem to be solved by the present invention is to provide an oil-in-water emulsion cosmetic excellent in moisturizing power.
  • the problem to be solved by the present invention is to provide an oil-in-water emulsion cosmetics to give elasticity to the skin.
  • the problem to be solved by the present invention is to provide an oil-in-water emulsified cosmetics that can at the same time give a flexible and refreshing feeling.
  • the problem to be solved by the present invention is to provide an oil-in-water emulsion cosmetic that can provide a cooling feeling while excellent in moisturizing power.
  • the problem to be solved by the present invention is to provide an oil-in-water emulsion cosmetic having excellent stability while having a low viscosity flow.
  • the problem to be solved by the present invention is to provide an oil-in-water emulsion cosmetic having excellent high temperature stability while containing a high content of inorganic salts.
  • the present invention is a double spheroid type polymer amphiphilic anisotropic powder consisting of a hydrophilic one and a hydrophobic other; And an oil-in-water emulsion cosmetic composition comprising an inorganic salt,
  • the powder has a structure in which the hydrophobic other partially penetrates into the inside of the hydrophilic one to form a hydrophilic one core, and the shell of the hydrophilic one includes a functional group, and provides an oil-in-water emulsion cosmetic composition.
  • the present invention can provide an oil-in-water emulsion cosmetic excellent in emulsion stability including inorganic salts.
  • the present invention can provide an oil-in-water emulsion cosmetic having excellent emulsion stability while containing a high content of inorganic salts.
  • the present invention can provide a light oil-in-water emulsion cosmetic.
  • the present invention can provide an oil-in-water emulsion cosmetic excellent in moisturizing power.
  • the present invention can provide an oil-in-water emulsion cosmetic to impart elasticity to the skin.
  • the present invention can provide an oil-in-water emulsion cosmetics that can give a flexible feeling and a refreshing feeling at the same time.
  • the present invention can provide an oil-in-water type emulsion cosmetic that can provide a cooling feeling while excellent in moisturizing power.
  • the present invention can provide an oil-in-water emulsion cosmetic having excellent stability while having a low viscosity flowability.
  • the present invention can provide an oil-in-water emulsion cosmetic having excellent high temperature stability while including a high content of inorganic salts.
  • FIG. 1 is a schematic diagram of forming an amphipathic anisotropic powder according to an embodiment of the present invention.
  • Example 2 is an optical microscope photograph of the emulsion particles immediately after the preparation of the composition of Example 1 and after storage at 45 ° C. for 2 weeks.
  • (meth) acryl may mean acryl and / or methacryl.
  • the particle size of the amphipathic anisotropic powder herein is a measure of the maximum length, which is the longest length of the powder particles.
  • the particle size range of the amphipathic powder herein means that at least 95% of the amphipathic anisotropic powder present in the composition falls within this range.
  • the average particle diameter of the emulsified particles means an average value of the diameters of the single particles.
  • the average particle diameter range of the emulsified particles means that at least 95% of the emulsified particles present in the composition fall within the range.
  • an oil-in-water emulsion cosmetic composition comprising an amphiphilic anisotropic powder and an inorganic salt.
  • the inorganic salt may impart a moisturizing and elasticity effect to the composition, for example, sodium chloride, potassium chloride, lithium chloride, calcium chloride and magnesium chloride may be used.
  • the inorganic salt may be included in 0.0001% to 5% by weight, for example 0.5% to 5% by weight based on the total weight of the composition.
  • the inorganic salt may be at least 0.0001 wt%, at least 0.001 wt%, at least 0.01 wt%, at least 0.05 wt%, at least 0.1 wt%, at least 0.2 wt%, at least 0.3 wt%, at least 0.4 wt%, 0.5 based on the total weight of the composition.
  • amphiphilic anisotropic powder may be a double spheroid type polymer amphipathic anisotropic powder composed of hydrophilic one and hydrophobic other.
  • the powder has a structure in which the hydrophobic other partially penetrates into the inside of the hydrophilic one to form a hydrophilic one core, and the hydrophilic one may include a functional group.
  • the powder may be a double spheroid type, that is, a three-dimensional nephroid shape having a shape in which two spheroids are combined, and a symmetrical shape and an asymmetrical snowman based on the combined part. snowman) shape or asymmetrical inverse snowman shape.
  • the snowman shape means that the first and second polymer spheroids having different sizes are bonded to each other.
  • the spheroid may be, for example, a sphere, globoid or oval shape, and may have a long axis length of micro units or nano units based on the longest length in the body cross section. have.
  • the hydrophilic one side may have a core-shell structure in which the core is made of the same polymer as the hydrophobic other side, and the hydrophilic one side and the hydrophobic other side may form one spheroid shape each of the double spheroids.
  • the coupling portion between the two spheroids of the double spheroid can be made into a structure that is continuous from the hydrophilic one core to the hydrophobic other.
  • the hydrophilic one core and the hydrophobic other include a vinyl polymer
  • the hydrophilic one shell may include a copolymer of a vinyl monomer and a monomer containing a functional group.
  • the vinyl polymer may be a vinyl aromatic polymer, for example, may be polystyrene.
  • the vinyl monomer may be vinyl aromatic. In one example, the vinyl monomer may be substituted or unsubstituted styrene.
  • the functional group may be a siloxane.
  • the monomer containing a functional group may be a siloxane-containing (meth) acrylate, specifically, 3- (trimethoxysilyl) propyl acrylate, 3- (trimethoxysilyl) propyl methacrylate, vinyl Triethoxysilane, vinyltrimethoxysilane or mixtures thereof.
  • the shell of the hydrophilic one side may be further introduced with a hydrophilic functional group.
  • the hydrophilic functional group may be a negatively charged or positively charged functional group or polyethylene glycol (PEG) series, carboxylic acid group, sulfone group, phosphate group, amino group, alkoxy group, ester group, acetate group, polyethylene glycol group and hydride It may be at least one selected from the group consisting of a hydroxyl group.
  • PEG polyethylene glycol
  • the hydrophilic one shell may be further introduced with a functional group containing a sugar.
  • the sugar-containing functional group is N- ⁇ N- (3-triethoxysilylpropyl) aminoethyl ⁇ gluconamide, N- (3-triethoxysilylpropyl) gluconamide and N- ⁇ N It may be derived from one or more selected from the group consisting of-(3-triethoxysilylpropyl) aminoethyl ⁇ -oligo-hyaluronamide.
  • the amphipathic anisotropic powder may have a particle size of 100 to 1500 nm.
  • the amphipathic anisotropic powder may have a particle size of 100 to 500 nm, or 200 to 300 nm.
  • the amphiphilic anisotropic powder has a particle size of 100 nm or more, 200 nm or more, 300 nm or more, 400 nm or more, 500 nm or more, 600 nm or more, 700 nm or more, 800 nm or more, 900 nm or more, 1000 nm 1100 nm or more, 1200 nm or more, 1300 nm or more, or 1400 nm or more, 1500 nm or less, 1400 nm or less, 1300 nm or less, 1200 nm or less, 1100 nm or less, 1000 nm or less, 900 nm or less, 800 nm or less , 700 nm or less, 600 n
  • the amphipathic anisotropic powder may form large emulsion particles of 1 to 100 ⁇ m. In another aspect, the amphipathic anisotropic powder may be to form large emulsified particles of 5 to 100 ⁇ m, 10 to 100 ⁇ m, 10 to 50 ⁇ m, or 25 ⁇ m.
  • the amphiphilic anisotropic powder may be 1 ⁇ m or more, 2 ⁇ m or more, 3 ⁇ m or more, 4 ⁇ m or more, 5 ⁇ m or more, 6 ⁇ m or more, 7 ⁇ m or more, 8 ⁇ m or more, 9 ⁇ m or more, 10 ⁇ m or more, 15 100 ⁇ m or less, 90 ⁇ m or less, 80 ⁇ m or less, 70 ⁇ m or less, 60 ⁇ m or less, 50 ⁇ m or more, 20 ⁇ m or more, 25 ⁇ m or more, 30 ⁇ m or more, 40 ⁇ m or more, 50 ⁇ m or more, or 80 ⁇ m or more Emulsified particles of not more than 40 ⁇ m, not more than 40 ⁇ m, not more than 30 ⁇ m, not more than 25 ⁇ m, not more than 20 ⁇ m, not more than 15 ⁇ m, not more than 10 ⁇ m or not more than 5 ⁇ m can be formed.
  • the hydrophobic portion and the hydrophilic portion of the amphiphilic anisotropic powder can form large emulsion particles by having different orientations to the interface. It is possible to provide an emulsion formulation of a flexible usability having a low viscosity by the large emulsion particles as described above.
  • the interfacial film formed by the general molecular level surfactant forms a dynamic emulsification state
  • the emulsified particles formed by the amphipathic anisotropic powder increase the thickness of the interfacial film to several hundred nm and form a strong interfacial film through strong bonding between the powders. Done.
  • the formation of such an interfacial film improves the stability of emulsification, and can maintain a stable emulsification state without being affected by an inorganic salt.
  • the composition comprises the amphiphilic anisotropic powder, for example, based on the total weight of the composition, for example, 0.1% by weight, 0.2% by weight, 0.3% by weight, 0.4% by weight, 0.5% by weight, 0.6% by weight or more , At least 0.7 wt%, at least 0.8 wt%, at least 0.9 wt%, or at least 1.0 wt%, at most 20 wt%, at most 19 wt%, at most 18 wt%, at most 17 wt%, at most 16 wt%, 15 wt% Or less, 14 or less, 13 or less, 13 or less, 12 or less, 11 or less, 10 or less, 9 or less, 8 or less, 7 or less, 6 or less, 5 or less Or less than 4%, or less than or equal to 3% by weight.
  • the composition may include the amphiphilic anisotropic powder in an amount of 0.1% to 20% by weight, for example, 1% to 3%, based on the total weight of the composition.
  • Stable emulsion particles can be formed within the above range, and emulsion particles of appropriate size can be formed.
  • the composition of the inorganic salt and the amphipathic anisotropic powder is a ratio of 1: 9-9: 1, for example 1: 9-5: 1, for example 2.0: 1.0 in the weight ratio of inorganic salt: amphiphilic anisotropic powder It can be included as. Within this range, a stable emulsified state can be maintained without being influenced by an inorganic salt.
  • the method of manufacturing a cosmetic composition according to an embodiment of the present invention may include preparing the amphiphilic anisotropic powder and emulsifying the oil phase part and the water phase using the prepared amphipathic anisotropic powder.
  • the amphiphilic anisotropic powder comprises a hydrophilic one (first polymer spheroid) and a hydrophobic other (second polymer spheroid), the hydrophilic one has a core-shell structure, hydrophobic other It is a structure which penetrates at least partially into the inside of the said hydrophilic one, and forms the core of one hydrophilic,
  • the said hydrophilic one shell is an oil-in-water type emulsion cosmetic composition containing a functional group.
  • the amphipathic anisotropic powder is prepared by polymerizing a first monomer to prepare a core of a first polymer spheroid, and coating a core of the first polymer spheroid to the first polymer sp of the core-shell structure It may be prepared to prepare the Lloyd, and reacting the first polymer spheroid and the first monomer of the core-shell structure to prepare an amphiphilic anisotropic powder in which the second polymer spheroid is formed.
  • FIG. 1 is a schematic diagram showing the principle of formation of amphipathic anisotropic powder according to an embodiment of the present invention.
  • the amphiphilic anisotropic powder may be prepared by (1) stirring a first monomer and a polymerization initiator to prepare a core of a first polymer spheroid; (2) stirring the core of the prepared first polymer spheroid with a monomer containing a first monomer, a polymerization initiator, and a functional group to prepare a coated core-shell structured first polymer spheroid; (3) stirring the first polymer spheroid of the core-shell structure prepared above with the second monomer and the polymerization initiator to prepare an amphiphilic anisotropic powder in which the second polymer spheroid is formed.
  • the stirring may be rotary stirring.
  • Rotational agitation is preferred because uniform mechanical mixing is required along with chemical modification to produce uniform particles.
  • the rotary stirring may be rotary stirring in a cylindrical rotary reactor, but the rotary stirring method is not limited thereto.
  • the size and location of the baffles in the cylindrical rotary reactor and the degree of spacing with the impeller greatly affect the uniformity of the particles produced. It is desirable to minimize the blade gap between the inner wing and the impeller to equalize the convective flow and its strength, and to supply the powder reaction liquid below the wing length and maintain the impeller rotation speed at a high speed. It may be rotated at a highway of 200 rpm or more, and the ratio of the length of the diameter and the height of the reactor may be 1 to 3: 1 to 5, more specifically, 10 to 30 cm in diameter and 10 to 50 cm in height. The reactor size can vary in proportion to the reaction capacity. In addition, the material of the cylindrical rotary reactor may be a ceramic, glass, and the like, the temperature of the stirring is preferably 50 to 90 °C.
  • the simple rotary method enables the production of uniform particles and is a low energy method that requires less energy, and has a characteristic of enabling mass production by maximizing reaction efficiency.
  • the tumbling method in which the reactor itself rotates in the related art requires high energy and rotates the reactor at a predetermined angle, thus requiring high energy and restricting the size of the reactor. Due to the limitations of the reactor size, the amount produced is also limited to small amounts of about several hundred mg to several g, making it unsuitable for mass production.
  • the core of the first polymer spheroid and the second polymer spheroid may include a vinyl polymer
  • the shell of the first polymer spheroid may include a copolymer of a vinyl monomer and a monomer containing a functional group
  • the vinyl polymer may be a vinyl aromatic polymer, for example, may be polystyrene.
  • the first monomer and the second monomer may be the same or different, specifically, may be a vinyl monomer.
  • the first monomer added in step (2) is the same as the first monomer used in step (1), the polymerization initiator used in each step may be the same or different.
  • the vinyl monomer may be vinyl aromatic. In one example, the vinyl monomer may be substituted or unsubstituted styrene.
  • the polymerization initiator may be a radical polymerization initiator, specifically, may be a peroxide-based, azo-based or a mixture thereof. Moreover, ammonium persulfate, sodium persulfate, potassium persulfate can also be used.
  • the first monomer and the polymerization initiator may be mixed in a weight ratio of 100 to 1000: 1. In another aspect, the first monomer and the polymerization initiator may be mixed in a weight ratio of 100 to 750: 1, or 100 to 500: 1, or 100 to 250: 1.
  • a stabilizer may be added together with the first monomer and the polymerization initiator to mix the first monomer, the polymerization initiator, and the stabilizer in a weight ratio of 100 to 1000: 1: 0.001 to 5.
  • the powder size and shape are determined according to the size adjustment of the first polymer spheroid in the initial stage (1), and the first polymer spheroid size can be adjusted according to the weight ratio of the first monomer, the polymerization initiator and the stabilizer.
  • the weight ratio of the said range there exists an effect which can raise the uniformity of anisotropic powder.
  • the stabilizer may be an ionic vinyl monomer, specifically sodium 4-vinylbenzenesulfonate may be used. Stabilizers prevent swelling of the resulting particles and impart positive or negative charges to the surface of the powder to electrostatically prevent mutual coalescence (bonding) during particle generation.
  • the weight ratio of the first monomer, the polymerization initiator, and the stabilizer is 110 to 130: 1: 1 to 5, specifically 115 to 125: 1: 1 to 2-4 It can be prepared from 1 polymer spheroid.
  • the weight ratio of the first monomer, the polymerization initiator and the stabilizer is 225 to 240: 1: 1 to 3, specifically 230 to 235: 1: 1 to 3 It can be prepared from the first polymeric spheroid.
  • the amphiphilic anisotropic powder has a size of 1100 to 2500 nm
  • the first polymer having a weight ratio of the first monomer, the polymerization initiator, and the stabilizer is 110 to 130: 1: 0, specifically 115 to 125: 1: 0 It can be prepared from spheroids.
  • amphipathic anisotropic powder of the asymmetrical snowman shape has a weight ratio of the first monomer, the polymerization initiator, and the stabilizer of 100 to 140: 1: 8 to 12, specifically 110 to 130: 1: 9 to 11 It can be prepared from polymeric spheroids.
  • amphipathic anisotropic powder of the asymmetric inverse snowman shape is made of a weight ratio of the first monomer, the polymerization initiator, and the stabilizing agent is 100 to 140: 1: 1 to 5, specifically 110 to 130: 1: 1 to 2-4 It can be prepared from 1 polymer spheroid.
  • the monomer containing a functional group in the step (2) may be a siloxane-containing (meth) acrylate, specifically, 3- (trimethoxysilyl) propyl acrylate, 3- (trimethoxysilyl) propyl Methacrylate, vinyltriethoxysilane, vinyltrimethoxysilane or mixtures thereof.
  • the monomer containing the first monomer, the polymerization initiator and the functional group in the step (2) may be mixed in a weight ratio of 80 to 98: 0.2 to 1.0: 1 to 20.
  • the first monomer, the polymerization initiator and the monomer containing a functional group may be mixed in a weight ratio of 160 to 200: 1: 6 to 40.
  • the degree of coating can be adjusted according to the weight ratio, and the shape of the amphipathic anisotropic powder is subsequently determined according to the degree of coating, and when reacting with the weight ratio, the coating thickness increases to about 10-30%, specifically 20%, relative to the initial thickness.
  • the coating is too thick so that powdering does not proceed or is too thin so that the powdering proceeds well without the problem of powdering in multiple directions. Moreover, by mixing in the weight ratio of the said range, there exists an effect which can raise the uniformity of anisotropic powder.
  • a part of the core of the first polymer spheroid protrudes through the shell from one direction of the first polymer spheroid of the core-shell structure, and the protrusion grows by the polymer of the second monomer to form an anisotropic powder. It can form the form of.
  • the second monomer and the polymerization initiator may be mixed in a weight ratio of 150 to 250: 1.
  • the second monomer and the polymerization initiator are 160 to 250: 1, or 170 to 250: 1, or 180 to 250: 1, or 190 to 250: 1, or 200 to 250: 1, or 210 to 250 It can be mixed in a weight ratio of: 1, or 220 to 250: 1, or 230 to 250: 1, or 240 to 250: 1.
  • the second monomer, the polymerization initiator and the stabilizer may be added together with the second monomer and the polymerization initiator to mix the second monomer, the polymerization initiator and the stabilizer in a weight ratio of 150 to 250: 1: 1: 0.001 to 5.
  • the specific kind of stabilizer is as above-mentioned.
  • the second monomer content in the step (3) may be mixed to 40 to 300 parts by weight when the weight of the first polymer spheroid of the core-shell structure is 100 parts by weight.
  • an asymmetric snowman type powder is obtained, and 100 to 150 parts by weight, or 110 to 150 parts by weight.
  • parts by weight a symmetrical powder is obtained, and in the case of 150 to 300 parts by weight, or in the case of 160 to 300 parts by weight, an asymmetric inverse snowman type powder is obtained.
  • by mixing in the weight ratio of the said range there exists an effect which can raise the uniformity of anisotropic powder.
  • (4) when preparing the amphipathic anisotropic powder according to an embodiment of the present invention, after the step (3), (4) may further include introducing a hydrophilic functional group into the prepared anisotropic powder. have.
  • the hydrophilic functional group in step (4) is not limited thereto, but may be introduced using a silane coupling agent and a reaction regulator.
  • the silane coupling agent is (3-aminopropyl) trimethoxysilane, N- [3- (trimethoxysilyl) propyl] ethylenediamine, N- [3- (trimethoxysilyl) propyl] ethylenedi Ammonium chloride, (N-succinyl-3-aminopropyl) trimethoxysilane, 1- [3- (trimethoxysilyl) propyl] urea and 3-[(trimethoxysilyl) propyloxy] -1,2 It may be one or more selected from the group consisting of propanediol, specifically N- [3- (trimethoxysilyl) propyl] ethylenediamine.
  • the silane coupling agent may be mixed in an amount of 35 to 65 parts by weight, for example 40 to 60 parts by weight, based on 100 parts by weight of the anisotropic powder prepared in step (3). Hydrophilization can be suitably made within the said range.
  • reaction modifier may be ammonium hydroxide.
  • reaction regulator may be mixed in an amount of 85 parts by weight to 115 parts by weight, for example 90 parts by weight to 110 parts by weight, based on 100 parts by weight of the anisotropic powder prepared in step (3). Hydrophilization can be suitably made within the said range.
  • the functional group containing sugar in step (4) is not limited thereto, but may be introduced using a sugar-containing silane coupling agent and a reaction regulator.
  • the sugar-containing silane coupling agent is N- ⁇ N- (3-triethoxysilylpropyl) aminoethyl ⁇ gluconamide, N- (3-triethoxysilylpropyl) gluconamide And N- ⁇ N- (3-triethoxysilylpropyl) aminoethyl ⁇ -oligo-hyaluronamide.
  • the reaction modifier may be ammonium hydroxide.
  • the reaction regulator may be mixed in an amount of 85 parts by weight to 115 parts by weight, for example 90 parts by weight to 110 parts by weight, based on 100 parts by weight of the anisotropic powder prepared in step (3).
  • Introduction of the functional group containing a sugar in the said range can be made suitably.
  • Amphiphilic anisotropic powder according to the above method does not use a crosslinking agent, there is no entanglement in production, the yield is high and uniform, and it is easy to mass-produce compared to the tumbling method using a simple stirring method.
  • composition according to the present embodiment has a viscosity of at least 1000 cps, at least 1100 cps, at least 1200 cps, at least 1300 cps, at least 1400 cps, at least 1500 cps, at least 1600 cps, at least 1700 cps, and at least 1800 cps.
  • composition according to the present embodiment contains an inorganic salt in a high content, it is possible to provide a composition having a wide range of viscosity as described above, since it is possible to maintain the stability of the emulsion formulation without increasing the viscosity by using an excessive thickener or the like. Can be.
  • low viscosity for example 10,000 cps or less, 5,000 cps or less, or 3,000 cps or less, such as 1,000 cps to 10,000 cps, 1,000 cps to 8,000 cps, 1,000 cps to 5,000 cps, or 3,000 cps
  • Low viscosity compositions in the range of from 5,000 cps are possible. It is possible to provide a flexible and flexible formulation within the above range can exhibit a fresh feeling without stickiness.
  • composition according to the present embodiment can form a stable emulsion formulation without including an excessive thickener or an excessive surfactant, a feeling of use is not deteriorated or a skin irritation is not caused by the thickener or the surfactant, and an excellent feeling of use and skin safety are achieved. Excellent compositions can be provided.
  • the composition according to the present embodiment may include an inorganic salt and may provide an emulsifying composition capable of providing moisturizing power.
  • the composition according to the present embodiment may provide an emulsified composition capable of providing skin elasticity including an inorganic salt.
  • composition according to this embodiment may comprise amphiphilic anisotropic powder to form an emulsion formulation having a firm emulsified interface that cannot be achieved in conventional surfactants. Therefore, it is possible to provide an oil-in-water emulsion composition that is excellent in emulsification stability and excellent in high temperature and time stability by not being disturbed by the high content of inorganic salts present in the aqueous phase.
  • the composition according to the present embodiment is excellent in emulsification stability in the oil-in-water emulsion formulation, including the inorganic salt, it can be given at the same time the beneficial effect of the inorganic salt while showing a non-sticky refreshing feeling as an emulsion composition.
  • the beneficial effect of the inorganic salt while showing a non-sticky refreshing feeling as an emulsion composition.
  • even in the presence of a high content of inorganic salts there is no effect on the stability and can exhibit the effects described above.
  • composition according to the present embodiment may exhibit emulsion stability over time in a wide temperature range, and the temperature may be, for example, -10 ° C to 60 ° C.
  • composition according to the present embodiment may include a large emulsified particle to provide a flexible and soft feeling.
  • composition according to the present embodiment may be formulated into various formulations such as lotions, emulsions, creams, and the like.
  • Cosmetic compositions according to embodiments of the present invention may be formulated containing a cosmetically or dermatologically acceptable medium or base. It is any formulation suitable for topical application, in the form of suspensions, microemulsions, microcapsules, microgranules or ionic (liposomal) and nonionic vesicle dispersants or creams, skins, lotions, powders, ointments, sprays or concealers. It may be provided in the form of a stick. It may also be used in the form of a foam or in the form of an aerosol composition further containing a compressed propellant. These compositions can be prepared according to conventional methods in the art.
  • the cosmetic composition according to the embodiments of the present invention may be a powder, a fatty substance, an organic solvent, a dissolving agent, a thickening agent, a gelling agent, a softening agent, an antioxidant, a suspending agent, a stabilizer, a foaming agent, a fragrance, a surfactant.
  • ionic or nonionic emulsifiers fillers, metal ion sequestrants, chelating agents, preservatives, vitamins, blockers, wetting agents, essential oils, dyes, pigments, hydrophilic or lipophilic active agents, lipid vesicles or cosmetics It may contain adjuvants conventionally used in the cosmetic or dermatological fields, such as any other ingredients used. Such adjuvants are introduced in amounts generally used in the cosmetic or dermatological arts.
  • the cosmetic composition according to the embodiments of the present invention may further contain a skin absorption promoting substance to increase the skin improving effect.
  • the component used by the following preparation example is as follows.
  • composition ratio (g) -average powder size 250nm per 1L reactor PS (1L shake reactor) CS DB Water 300 PS 300 CS 240 MeOH 40 Water 250 Water 350 Styrene 50 TMSPA 6 AIBN 0.2 KPS 0.5 Styrene 50 Styrene 40 SVBS 1.0 AIBN 0.2 SVBS 0.35
  • KPS Potassium persulfate (initiator)
  • SVBS Sodium vinyl benzene sulfonate (stabilizer)
  • AIBN Azobisisobutyronitrile (polymerization initiator)
  • Example 1 is an emulsion composition prepared using the amphipathic anisotropic powder prepared according to Preparation Example 3
  • Comparative Examples 1 to 2 are emulsion compositions using a general surfactant.
  • Test Example 2 Formulation stability with time and temperature rating
  • Formulation stability of the compositions according to Examples 1 and Comparative Examples 1 and 2 were observed at 45 ° C. for 2 weeks, and the results are shown in Table 4 below.
  • Example 1 Comparative Example 1 Comparative Example 2 Creaming stability stability Creaming Whether oil is separated stability Oil separation Oil separation
  • Comparative Example 2 In the case of creaming occurs, the oil is separated can be confirmed that the formulation is unstable and unable to maintain the emulsified state. On the other hand, the composition of Example 1 does not appear creaming or oil separation phenomenon even when maintained at a high temperature for a long time, there is no discoloration or odor does not appear to maintain a stable emulsion formulation.
  • Example 1 and Comparative Example 2 were maintained at 45 ° C. for 2 weeks, and immediately after the preparation and after 2 weeks, the emulsion particles were observed under an optical microscope to confirm the change over time. The results are shown in FIGS. 2 and 3.
  • Example 2 the composition of Example 1 can be confirmed that the emulsion particles formed immediately after the preparation is maintained stably without significant fluctuation even after two weeks at 45 °C.
  • Comparative Example 2 it can be seen that the small emulsion particles formed initially to aggregate together to form large particles and collapse the emulsified state.

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  • Veterinary Medicine (AREA)
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  • General Health & Medical Sciences (AREA)
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Abstract

La présente invention concerne une composition de matière cosmétique émulsifiant de type huile dans l'eau comprenant : une poudre de polymère anisotrope amphipathique de type sphéroïde double comprenant un côté hydrophile et un côté hydrophobe; et un sel inorganique, la poudre ayant une structure dans laquelle le côté hydrophobe pénètre partiellement dans le côté hydrophile pour former un noyau dans le côté hydrophile et le côté hydrophile comprend un groupe fonctionnel.
PCT/KR2017/010471 2016-09-26 2017-09-22 Composition de matière cosmétique de type huile dans l'eau comprenant un sel inorganique et son procédé de préparation WO2018056750A1 (fr)

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100190990B1 (ko) * 1995-12-08 1999-06-15 성재갑 수중유형 화장료 조성물
KR20100055087A (ko) * 2008-11-17 2010-05-26 (주)아모레퍼시픽 전상온도유화법을 이용하여 수중유형 에멀젼 제조 시 전상온도의 조절방법, 이를 통하여 제조한 ｏ/ｗ형 나노에멀젼 및 이를 함유하는 화장료 조성물
KR20150138012A (ko) * 2014-05-30 2015-12-09 (주)아모레퍼시픽 양친매성 이방성 분체를 포함하는 화장료 조성물 및 이의 제조방법
KR20160082475A (ko) * 2014-12-31 2016-07-08 (주)아모레퍼시픽 화학적 이방성 분체 및 이를 함유하는 효능 원료가 안정화된 화장료 조성물
KR20160081821A (ko) * 2014-12-31 2016-07-08 (주)아모레퍼시픽 화학적 이방성 분체 및 이를 함유하는 화장료 조성물

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100190990B1 (ko) * 1995-12-08 1999-06-15 성재갑 수중유형 화장료 조성물
KR20100055087A (ko) * 2008-11-17 2010-05-26 (주)아모레퍼시픽 전상온도유화법을 이용하여 수중유형 에멀젼 제조 시 전상온도의 조절방법, 이를 통하여 제조한 ｏ/ｗ형 나노에멀젼 및 이를 함유하는 화장료 조성물
KR20150138012A (ko) * 2014-05-30 2015-12-09 (주)아모레퍼시픽 양친매성 이방성 분체를 포함하는 화장료 조성물 및 이의 제조방법
KR20160082475A (ko) * 2014-12-31 2016-07-08 (주)아모레퍼시픽 화학적 이방성 분체 및 이를 함유하는 효능 원료가 안정화된 화장료 조성물
KR20160081821A (ko) * 2014-12-31 2016-07-08 (주)아모레퍼시픽 화학적 이방성 분체 및 이를 함유하는 화장료 조성물

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