WO2018028722A2 - Structure de retenue et détecteur comprenant une structure de retenue - Google Patents

Structure de retenue et détecteur comprenant une structure de retenue Download PDF

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Publication number
WO2018028722A2
WO2018028722A2 PCT/CN2017/105434 CN2017105434W WO2018028722A2 WO 2018028722 A2 WO2018028722 A2 WO 2018028722A2 CN 2017105434 W CN2017105434 W CN 2017105434W WO 2018028722 A2 WO2018028722 A2 WO 2018028722A2
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WO
WIPO (PCT)
Prior art keywords
plate
holding structure
structure according
retainer
orifice
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Application number
PCT/CN2017/105434
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English (en)
Chinese (zh)
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WO2018028722A3 (fr
Inventor
廖玮
李宇锋
郭才华
张晨光
Original Assignee
广州易活生物科技有限公司
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Application filed by 广州易活生物科技有限公司 filed Critical 广州易活生物科技有限公司
Publication of WO2018028722A2 publication Critical patent/WO2018028722A2/fr
Publication of WO2018028722A3 publication Critical patent/WO2018028722A3/fr

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means

Definitions

  • the present invention relates to a holding structure for holding a sample detecting orifice, and to a detector including the holding structure.
  • an orifice plate with a plurality of holes is usually used to hold the biological sample, and the electrode of the orifice plate is electrically connected to the bottom of the hole, thereby weak current signal of the biological sample.
  • the signal can be detected by the electrode output to the outside of the orifice plate.
  • the current signal that can be detected is also very weak, usually in the order of nanoamperes or picoamperes. In the existing detection equipment, it is generally only possible to detect the mA level.
  • a holding structure capable of repeatedly placing an orifice plate and preventing the orifice plate from being knocked over, and outputting the current signal of the electrode to the signal detection processing unit to ensure the loading of the electrical signal and the stability of the transmission of the detection signal, and try to It reduces the interference of external electromagnetic on the output current signal, and at the same time realizes the sealing of the detection equipment to prevent external water vapor, dust and liquid from penetrating into the equipment.
  • the present invention achieves the above object by proposing a holding structure for holding a sample detecting orifice plate with electrodes and containing a sample.
  • the retaining structure includes a retainer and a pressure conversion plate.
  • the holder includes: a holder body having a receiving portion that receives the orifice plate; and at least one probe module disposed at a bottom of the receiving portion.
  • the probe module includes: a plurality of contact probes, one end of the contact probe includes a spring contact that is perpendicular to a bottom of the accommodating portion and the other end is electrically connected to the keeper control circuit; at least one switch probe a needle, one end of the switch probe including an elastic pressing portion that is perpendicular to a bottom of the accommodating portion and the other end is electrically connected to a holder control circuit; and an electrically insulating plate, the contact probe and the The switch probe is disposed on the electrical insulation board.
  • the bottom of the orifice plate is pressed against the elastic contact of the contact probe and the elastic pressing portion of the switch probe, and the elastic contact is electrically Connected to an electrode disposed on the bottom of the orifice plate, and the orifice plate is located between the pressure conversion plate and the bottom of the receiving portion.
  • the pressure conversion plate is rotatably mounted about an axis of symmetry thereof.
  • the retainer includes a retainer flap that rotates relative to the retainer body about a first axis, the pressure conversion plate is mounted on the retainer flip, and the symmetry of the pressure conversion plate is rotated
  • the axis is parallel to the first axis.
  • the retainer flap has a flip hollow opening, and the pressure conversion panel is received in the flip hollow opening.
  • the pressure conversion plate and the holder flap are provided with cooperating rotation blocking means.
  • the pressure conversion plate has positioning means for positioning the orifice plate.
  • it is part of a detector that is mounted on the cover of the detector.
  • the cover of the detector rotates relative to the casing about the second axis and has a receiving portion, the pressure conversion plate is received in the receiving portion, and the axis of symmetry about which the pressure conversion plate rotates is parallel to The second axis.
  • the pressure conversion plate and the chassis cover are provided with cooperating rotation blocking devices.
  • the pressure conversion plate is in the form of a hollow rectangular frame.
  • the accommodating portion includes a fence protruding outward from a bottom of the accommodating portion to surround the orifice plate, and the accommodating portion is electrically insulated and formed with the electrically insulating plate One.
  • the retainer body includes a closed annular wall that projects outwardly from the retainer body and is located at a periphery of the fence, the closed annular wall carrying a seal.
  • the holder further includes a support plate supporting the holder body, the support plate includes a notch, and the contact probe and the switch probe pass through the gap without contact with the support plate .
  • the support plate is located below the holder body and has a first side facing the holder body and a second side facing away from the holder body, the support plate being fixed to the warranty A holder body, a control board carrying the holder control circuit is fixed to the support plate at a second side of the support plate and spaced apart from the support plate.
  • the support plate is made of a metal material.
  • the accommodating portion includes a case accommodating the orifice plate, and the electrically insulating plate is disposed on a bottom of the case.
  • the holder body is made of a metal material.
  • the accommodating portion further comprises an orifice plate close to the space.
  • the probe module comprises a plurality of switch probes.
  • the switch probe is a normally open switch.
  • the bottom of the receiving portion is provided with an error prevention device for the orifice plate.
  • the invention also relates to a detector comprising the above-described holding structure and a housing.
  • the present invention also relates to a holding structure for holding a sample detecting orifice plate for accommodating a sample to be detected, and having an electrode, wherein the holding structure includes a holder and a pressure conversion plate,
  • the holder includes a holder body having a receiving portion for receiving the sample detecting orifice plate, and a probe module is disposed at a bottom of the receiving portion, and the sample detecting orifice plate is received in the receiving portion In the middle, it is located between the pressure conversion plate and the probe module.
  • the probe module comprises a plurality of probes and an electrically insulating plate for fixing the probes, one end of the plurality of probes being pressed against the bottom of the sample detecting orifice plate and capable of being opposite to the The sample detection orifice is elastically moved and the other end is connected to the holder control circuit.
  • the plurality of probes comprise: a probe body; an elastic moving portion received in the probe body, one end extending outward from the probe body for use with the sample detecting orifice plate a bottom abutment; and an elastic member housed in the probe body abutting against the other end of the elastic moving portion.
  • the probe body has a tubular shape, is disposed on the electrically insulating plate, has an opening at one end, has a terminal connected to the holder control circuit at the other end, and defines an interior thereof An open communication stroke space, the elastic moving portion having a shoulder engaged with a peripheral portion of the opening, an upper portion extending from the shoulder toward the outside of the opening, and the stroke from the shoulder to the stroke A lower section extending within the space and the resilient means disposed between the lower section and the bottom of the travel space.
  • the plurality of probes comprise: a plurality of contact probes, wherein the sample detection orifice plate is Receiving in the accommodating portion, wherein the elastic moving portion is in elastic contact with the electrode of the bottom of the orifice plate, is pressed by the electrode to move within a total stroke defined by the stroke space; and at least one a switch probe, wherein the elastic moving portion elastically contacts the bottom of the sample detecting orifice plate when the sample detecting orifice plate is received in the accommodating portion, and is pressed by the sample detecting orifice plate The movement within the total stroke defined by the stroke space is turned on when all of the switch probes are pressed to be turned on.
  • the switch probe is arranged to trigger its on state when it is depressed by a predetermined trigger stroke, and at this point the contact probe is in a preferred use stroke with the best performance state.
  • the preferred use stroke is from 60% to 70% of the total stroke.
  • the number and location of the contact probes correspond to the number and location of electrodes at the bottom of the sample detection aperture plate.
  • the contact probe is entirely made of a metal material.
  • the retainer includes a retainer flap that rotates relative to the retainer body about a first axis, the pressure conversion plate being rotatably mounted about the axis of symmetry thereof on the retainer flip, the symmetry The axis is parallel to the first axis.
  • the holder flip has a flip hollow opening, the pressure conversion plate being received in the flip hollow opening, the pressure conversion plate being disposed along the two edges perpendicular to the axis of symmetry A symmetrical axially outwardly extending shaft, the two of which are mounted on corresponding corresponding axle seats on the retainer flip.
  • the pressure conversion plate has positioning means for positioning the sample detecting orifice.
  • the positioning device is a positioning post disposed on the pressure conversion plate, and cooperates with a cutout portion provided on the sample detecting orifice plate.
  • the pressure conversion plate and the holder flap are provided with cooperating rotary resistance means for limiting the angle of rotation of the pressure conversion plate about the axis of symmetry.
  • the rotation blocking device includes: a bar disposed on an edge of the pressure conversion plate parallel to the axis of symmetry; and a position on the holder flap corresponding to the bar The recess.
  • the retainer flap includes a buckle at a free edge opposite the first axis, and the retainer body is provided with a latching fastener that cooperates with the latch to hold The retainer flap and the retainer body are locked when the flip is closed.
  • a sensor is disposed in the buckle fixing member, and when the buckle and the buckle fixing member are correctly locked and locked, the sensor sends a notification to the holder control circuit that the holder flip cover is closed.
  • the signal, the keeper control circuit can start the detection process.
  • the retainer flap is attached to the retainer body by a damper type flap that allows the retainer flap to rest in any of its rotational positions.
  • the pressure conversion plate has a hollow window allowing loading of the sample detection orifice through the hollow window.
  • the pressure conversion plate has the form of a flat rectangular frame with a periphery of the pressure conversion plate pressed against the periphery of the sample detecting orifice.
  • the accommodating portion when the sample detecting orifice plate is received in the accommodating portion, a finger of the operator is allowed to be inserted therein, and is disposed on both sides of the sample detecting orifice plate The orifice plate is close to the space.
  • the accommodating portion is designed to accommodate two types of sample detecting orifice plates of different types, and the orifice plates on both sides of the first type of sample detecting orifice plate are close to the space when receiving the second type of sample
  • the orifice plate is detected, it is occupied by the sample detecting orifice plate of the second type, and the space originally occupied by the sample detecting orifice plate of the first type is located on both sides of the sample detecting orifice plate of the second type.
  • the orifice plate of the second type of sample detection orifice plate is close to the space.
  • a probe module for the second type of sample detection orifice is disposed in the orifice access space for the first type of sample detection orifice.
  • the holder body has a shield case disposed at a bottom thereof, the shield case being made of a metal material and carrying a control plate of the holder control circuit inside.
  • the fence projecting outwardly from the bottom of the accommodating portion, the fence surrounding the sample detecting orifice plate and restricting its horizontal sliding.
  • the fence is located on opposite sides of the sample detecting orifice.
  • the fence is located on two corners of the diagonal of the sample detecting orifice.
  • the retainer body includes a closed annular wall that projects outwardly from the retainer body and is located at a periphery of the fence, the closed annular wall carrying a seal.
  • the retainer body has a protruding misalignment prevention post disposed at a bottom of the receiving portion, the misalignment prevention post being engageable with a recess provided at a bottom of the sample detecting orifice.
  • the holder includes a support plate located below the holder body and supporting the holder body, the support plate being made of a metal material, the support plate being provided with the probe to the upper side A notch passing therethrough is fixed at a lower side of the support plate to a control panel carrying the holder control circuit spaced apart from the support plate.
  • the invention also relates to a detector, comprising: a casing and the holding structure housed in the casing, the casing comprising: a casing body with an open top side; a casing cover rotatable relative to the casing body, And sealingly closing the casing to form a sealed interior space; and a table surface fixed and covering the top side of the casing and enclosing the interior volume of the casing for accommodating the retaining structure, including The mesa opening, the retainer of the retaining structure is exposed from the mesa opening.
  • annular groove surrounding the receiving portion is provided in the upper surface of the retainer body of the retaining structure, in which a seal is provided, the seal being in sealing engagement with the table.
  • the mesa is a flat metal plate, and the periphery is sealingly fixed to a side of the casing body,
  • the cover and the casing are made of a metal material.
  • an observation window for observing the sample detecting orifice plate is disposed on the casing cover.
  • the holding structure according to the present invention can ensure that the orifice plate is properly held and its bottom electrode can be in firm contact with the contact probe, thereby avoiding an open circuit, so that the circuit can continuously and stably supply power to the electrode on the orifice plate, and the current signal can Transfer without interruption.
  • the detector according to the present invention can effectively shield electromagnetic waves from the indoor space and electromagnetic interference of the electromagnetic radiation of the internal electronic components of the device against the current signal output from the electrodes, while preventing external moisture, dust and liquid from penetrating into the interior of the device.
  • Figure 1 is a perspective view of a first embodiment of a retaining structure in accordance with the present invention
  • FIG. 2A is a cross-sectional view of the contact probe along its longitudinal direction
  • FIG. 2B is a schematic view of the contact probe as it is inserted through the electrically insulating plate
  • Figure 3 is a schematic view showing the orifice plate pressed against the contact probe and the switch probe;
  • Figure 4 shows schematically the working principle of the pressure conversion plate
  • Figure 5 is a top plan view of the retaining structure shown in Figure 1 with the retainer flip of the retainer closed;
  • Figure 6 is a top plan view of the retaining structure shown in Figure 1 with the retainer flip open of the retainer;
  • Figure 7 is a perspective view of the retaining structure shown in Figure 1 as viewed from below;
  • Figure 8 is a perspective view of a second embodiment of a retaining structure in accordance with the present invention.
  • Figure 9 is a plan view of the retaining structure shown in Figure 8.
  • Figure 10 is a perspective view of the retaining structure shown in Figure 8, showing the bottom of the retainer body;
  • Figure 11 is a side cross-sectional view of the retaining structure shown in Figure 8.
  • Figure 12 is a perspective view of a first embodiment of a detector in accordance with the present invention.
  • Figure 13 is a perspective view of the detector shown in Figure 12, wherein the outer cover of the chassis is opened and the retaining structure is removed;
  • Figure 14 is a partial schematic view showing the manner of sealing engagement between the chassis of the detector and the holder body shown in Figure 12;
  • Figure 15A is a perspective view of the retainer body of the third embodiment of the retaining structure according to the present invention as viewed from above;
  • Figure 15B is a schematic view of an example of a fence
  • Figure 16 is a perspective view of the retainer body of the retaining structure shown in Figure 15A as viewed from below;
  • 17A and 17B are schematic views of an example of a pressure conversion plate
  • Figure 18 is a schematic illustration of a second embodiment of a detector in accordance with the present invention.
  • Figure 19 is a side cross-sectional view of the detector shown in Figure 18;
  • 20 and 21 are schematic views, respectively, of a detector including a retention structure in accordance with various embodiments of the present invention.
  • Figure 1 shows a retaining structure 1 according to a first embodiment of the invention for holding a sample sensing orifice plate (not shown in Figure 1) with electrodes and containing a sample.
  • the retaining structure 1 can include a retainer 10.
  • the holder 10 can include a holder body 100 that can have a receptacle 110 that can receive an orifice plate.
  • the holder 10 may further include at least one probe module 200 disposed at the bottom portion 111 of the accommodating portion 110.
  • the holder 10 can include two probe modules 200 (Fig. 5).
  • the probe module 200 can include a plurality of contact probes 210 and an electrically insulating plate 230.
  • a structure of a contact probe 210 is shown.
  • the contact probe 210 can include a contact probe body 212, for example having a tubular shape, the contact probe body 212 can be threaded over the electrically insulating plate 230 (FIG. 2B), for example, by an interference fit. Wear it.
  • the contact probe body 212 can have an opening 214 at one end and internally define a stroke space 213 that communicates with the opening 214.
  • the contact probe body 212 is unobstructed at the other end opposite the opening 214 and includes a terminal 215 electrically connected to the holder circuit at the end.
  • the contact probe 210 may further include a spring contact 211 that is movable perpendicular to the bottom portion 111 of the accommodating portion 110.
  • the spring contact 211 can include an upper section 2111, a shoulder 2112, and a lower section 2113.
  • a shoulder 2112 and a lower section 2113 are located in the stroke space 213, the shoulder 2112 being engageable in a stroke space to a peripheral portion defining the opening 214, the upper section 2111 extending from the shoulder 2112 to the opening 214, the lower section Segment 2113 extends from shoulder 2112 toward the interior of the travel space.
  • a resilient means 216 such as a coil spring, may be disposed between the lower section 2113 and the bottom of the travel space.
  • the resilient contact 211 can translate downward against the restoring force of the spring 216, and the shoulder 2112 disengages from engagement with the peripheral portion of the opening 214.
  • the spring contact 211 can be reset by the restoring force of the spring 216.
  • the contact probe 210 as a whole may be made of a metal material. The number of contact probes 210 and their positions correspond to the number of electrodes 91 at the bottom of the orifice plate 9 and their positions.
  • the probe module 200 can further include at least one switch probe 220, as shown in FIG.
  • the switch probe 220 is also disposed on the electrically insulating plate 230, for example, by an interference fit, and one end thereof may include an elastic pressing portion 221 that is perpendicular to the bottom portion 111 of the accommodating portion 110, and the other end has an electrical connection.
  • the internal structure of the switch probe 220 can be similar to the internal structure of the contact probe 210.
  • FIG. 3 also schematically shows the orifice plate 9, and the electrode 91 disposed on the bottom of the orifice plate 9.
  • the bottom of the orifice plate 9 is pressed against the contact
  • the elastic contact 211 of the needle 210 and the elastic pressing portion 221 of the switch probe 220 are simultaneously electrically connected to the electrode 91 on the bottom of the orifice plate 9.
  • the probe module 200 can include a plurality of switch probes 220, such as two, three, four, or even more.
  • the holder 10 may be provided with a total of four switch probes 220, for example, respectively disposed at the corners of the accommodating portion 110, so that when the orifice plate 9 is placed in the accommodating portion and the pressure conversion plate is not depressed, it is maintained. smooth. In the normal state, all the switch probes 220 are in the off state. When the orifice plate 9 is pressed against the contact probe 210 and the switch probe 220 by the force F2, all the switch probes 220 are turned on, and the holder control circuit is Turned on, thereby preventing the circuit from being accidentally turned on for invalid detection.
  • the contact probe 210 can have a preferred use stroke, for example 60% to 70% of the total stroke, in particular, at two-thirds of the total stroke of the contact probe 210, the contact probe has the best Performance state, at this time, its elastic force, electrical contact status of internal parts, and service life are in an optimal state.
  • the switch probe 220 can detect whether the contact probe 210 is within its preferred use stroke. Specifically, when the switch probe 220 is pressed for the next trigger stroke (eg, greater than or equal to 60% of the total stroke of the switch probe), its ON state is triggered. The on and off conditions of the circuit can be detected to know if the switch probe is pressed down to the trigger stroke, thereby knowing whether the contact probe is pressed to the preferred use stroke.
  • the holder main body 100 may be made of a metal material. Further, the accommodating portion 110 of the holder main body 100 may include a casing 112 accommodating the orifice plate, the periphery of which is fitted with the outer peripheral shape of the orifice plate 9, so that the orifice plate 9 is easily placed and taken out and its horizontal sliding is restricted.
  • the case 112 may be made of a metal material, and the electric insulation plate 230 may be disposed on the bottom of the case 112. At this time, the bottom of the casing 112 is provided with a notch (not shown) through which the contact probe 210 and the switch probe 220 pass without contact with the metal casing 112.
  • the holder 10 may include a holder flip 300 that rotates relative to the holder body 100 about a first axis X1-X1, for example, made of a metal material.
  • the holder flip 300 can be attached to the holder body 100 by a hinge 301 to rotate relative thereto.
  • the holder flip cover 300 may cover above the accommodating portion 110.
  • the hinge 301 can be, for example, a damper type flap, allowing the holder flap 300 to stay in any rotational position without falling freely, avoiding accidental impact on the orifice 9.
  • the retaining structure 1 may further comprise a pressure conversion plate 20, which is for example also made of a metallic material.
  • the pressure conversion plate 20 can be mounted on the holder flip 300.
  • the orifice plate 9 When received in the accommodating portion 110, the orifice plate 9 is located between the pressure conversion plate 20 and the bottom portion 111 of the accommodating portion 110.
  • the pressure conversion plate 20 is rotatably mounted about its axis of symmetry A-A on a retainer flip 300 that is parallel to the first axis X1-X1 around which the retainer flip 300 rotates relative to the retainer body 100.
  • the retainer flip 300 can have a flip hollow opening 302 into which the pressure conversion panel 20 can be received.
  • the rotation of the pressure conversion plate 20 relative to the holder flap 300 can be achieved by (FIG. 17A), with the shaft 21 extending outward along the axis of symmetry AA at both edges of the pressure conversion plate 20 perpendicular to the axis of symmetry AA.
  • the two shafts 21 are mounted on respective axle seats of the retainer flip cover 300 (not shown).
  • the pressure conversion plate 20 can have a hollow window 23 allowing automatic loading.
  • FIG. 4 shows a schematic diagram of the operation of the pressure conversion plate 20 mounted on the holder flip 300.
  • the pressure conversion plate 20 may first contact the edge of the orifice plate 9 near the first axis X1-X1. 92.
  • the pressure conversion plate 20 since the pressure conversion plate 20 is rotatable relative to the holder flip 300 and does not generate a force for moving the orifice plate 9 downward, the pressure conversion plate 20 abuts against the orifice plate 9 when the holder flap 300 continues to rotate.
  • the edge 92 is rotated about the axis of symmetry AA in the direction indicated by the arrow D until the pressure conversion plate 20 fits over the upper surface of the orifice plate 9.
  • the pressure conversion plate 20 can apply a force to the orifice plate 9 that is uniform and substantially perpendicular to the upper surface of the orifice plate 9 (as indicated by force F2 in FIG. 3), ie, the direction of the force is approximately
  • the direction in which the elastic contact portion 211 of the contact probe 210 and the elastic pressing portion 221 of the switch probe 220 move is parallel.
  • the accommodating portion 110 can receive a 96-hole rectangular orifice plate 9, and the pressure conversion plate 20 can have the form of a flat rectangular frame.
  • the pressure conversion plate 20 is The periphery can be pressed against the periphery of the orifice plate 9.
  • the pressure conversion plate 20 and the retainer flip cover 300 may further include rotational blocking means that cooperate with each other.
  • a baffle 22 shown in Figure 17A
  • a recess 303 (FIG. 6) may be provided at a position of the holder flip 300 corresponding to the lever 22, and the lever 22 may be received in the recess 303.
  • the rectangular pressure conversion plate 20 may be provided with a baffle 22 on both edges parallel to the axis of symmetry A-A.
  • the rotation blocking device having a fitting form may have other forms than the above, and may be disposed at other positions of the holder flap 300 and the pressure conversion plate 20 as long as the limited angle of the pressure conversion plate 20 with respect to the holder flip 300 is achieved.
  • the relative rotation can be.
  • the arrangement of the rotation blocking means can avoid accidental impact and damage to the orifice plate 9 due to the free rotation of the pressure conversion plate 20 during the downward rotation of the holder flap 300.
  • the pressure conversion plate 20 may further be provided with positioning means, for example, a positioning post 24 (FIG. 6), which is also protected Wrong device.
  • a positioning post 24 (FIG. 6)
  • the positioning post 24 may be disposed at a vertex portion of the pressure conversion plate 20, for example at two adjacent vertex portions, as shown in FIG.
  • the locating post 24 can extend generally perpendicular to the pressure conversion plate 20 in a direction toward the upper surface of the orifice plate 9, i.e., when the retainer flip 300 is closed, the locating post 24 extends toward the accommodating portion 110.
  • a cutout portion may be provided at a corresponding position of the orifice plate 9, and when the holder flap 300 is closed, the positioning post 24 may be received in a corresponding cutout portion of the orifice plate 9.
  • the cutout portion may have, for example, a shape of a rectangle, a triangle, or the like corresponding to the positioning post 24.
  • the number of positioning posts 24 need not be two, it may be other numbers, such as one or three, and the position of the positioning posts 24 need not be as shown in FIG. 6, as long as the correct positioning of the orifice plate 9 is ensured.
  • Figure 5 is a top plan view of the retaining structure 1 shown in Figure 1 with the retainer flap 300 of the retainer 10 closed.
  • Figure 6 is a top plan view of the retaining structure 1 shown in Figure 1 with the retainer flip 300 of the retainer 10 open.
  • the holder flip 300 can further include a handle 303 and a buckle 304 rotatable relative to the handle 303, the handle 303 and the catch 304 can be disposed at a free edge of the holder flip 300 opposite the hinge 301 .
  • the holder body 100 may be provided with a latch fixing member 101 that cooperates with the latch 304 to lock the holder flip cover 300 and the holder main body 100 when the holder flip cover 300 is closed, thereby pressing the orifice plate 9 tightly.
  • the electrode 91 of the orifice plate 9 is brought into firm contact with the elastic contact 211 of the contact probe 210.
  • a sensor (not visible to the operator) can be provided within the latching fixture 101 that is coupled to the keeper control circuit and can send a signal to the keeper control circuit.
  • the sensor sends a signal to the keeper control circuit indicating that the keeper flip 300 is closed in place, at which point the keeper control circuit can initiate the detection process.
  • the holder body 100 may further be provided with a groove 104 which is located in the upper surface of the holder body 100.
  • the groove 104 may be an annular groove surrounding the receiving portion 110, A seal, such as a seal ring 105, may be provided therein.
  • FIG. 7 shows a perspective view of the holder main body 100 as viewed from below.
  • the holder body 100 can include a holder body post 102 for supporting the holder 10 within the housing of the detector.
  • the holder body 100 may further include a shield case 120 disposed on a bottom of the holder body 100.
  • the shield case 120 may be made of a metal material having a parallelepiped shape, one side of the shield case 120 being open and fixed to the bottom of the holder body 100 at the open side, for example, by opening the outwardly projecting edge 121 around the side surface Come fixed.
  • the shield box 120 carries a control board of the holder control circuit, for example, a printed circuit board, which may be disposed inside the shield case 120.
  • the contact probe 210 and the switch probe 220 can pass through solder holes on the control board and be fixed to the control board by soldering, thereby achieving their electrical connection with the holder control circuit.
  • At least one hole may be provided on the other side of the shield case 120, for example, four holes 122 as shown in FIG. 7, from which a lower terminal 225 of a switch probe is passed.
  • FIGS 8-11 show schematic views of a retaining structure 1' in accordance with a second embodiment of the present invention.
  • This holding structure 1' is for holding another orifice plate 9' different from the orifice plate 9 in the first embodiment, for example, an orifice plate 9' having 16 holes.
  • the retaining structure '1' can include a retainer 10'.
  • the holder 10' can include a holder body 100' having a receiving portion 110' capable of receiving an orifice plate.
  • the holder 10' may further include at least one probe module 200 disposed at the bottom portion 111' of the housing portion 110'.
  • the configuration of the probe module 200 can be similar to the configuration of the probe module 200 in the first embodiment according to the present invention, but the number and position of the contact probes 210 are set for the orifice plate 9'.
  • the holder body 100' may be made of a metal material.
  • the accommodating portion 110' of the holder main body 100' may include a case body 112' accommodating the orifice plate, for example, made of a metal material.
  • the electrically insulating plate 230 may be disposed on the bottom of the casing 112', the bottom portion being provided with a notch, and the contact probe 210 and the switch probe 220 pass through the notch in contact with the metal casing 112' without contact.
  • the accommodating portions 110, 110' will be described below with reference to Figs. 1, 8, and 9.
  • the accommodating portions 110, 110' may include orifice plate proximity spaces 113, 113' (indicated by dashed boxes) that allow an operator's fingers to be inserted therein to easily place and remove the orifice plates 9 and 9'.
  • the orifice close to space 113 is disposed on both sides of the long side of the 96-well plate 9 and is centered; in the example of Figs. 8 and 9, the orifice close to the space 113' is provided in the 16-well plate 9' The sides of the long side are centered.
  • the long side of the 16-well plate 9' is substantially perpendicular to the long side of the 96-well plate 9.
  • the present invention provides a different orifice plate (eg, 96-well plates 9 and 16)
  • the orifice plates 9') share the accommodating portions 110, 110'.
  • the shared accommodating portion 110, 110' When the shared accommodating portion 110, 110' receives the first type of orifice plate (for example, the 96-well plate 9), the orifice plate close to the space 113' is occupied by the first type of orifice plate; when the shared accommodating portion 110, 110 is shared 'When receiving a second type of orifice plate (eg 16-well plate 9'), the orifice plate proximity space 113 is occupied by a second type of orifice plate, in particular, the probe module 200 for the second type of orifice plate 9' may The orifice plate for the first type orifice plate 9 is disposed in the space 113 (Fig. 9).
  • the shared accommodating portions 110, 110' allow the components having the same shape to be manufactured first, and then different settings according to the different orifice plates for which they are directed, such as the position of the probe module, the position of the bottom notch, etc., thereby saving material And the cost.
  • the pressure conversion plate 20' may be disposed in the hollow opening of the holder flip 300', but its shape is different from that of the pressure conversion plate 20 in the first embodiment, Rather, it is suitable for a second type of orifice plate, such as a 16-well plate 9'.
  • a control board 130 carrying a holder control circuit located below the electrically insulating plate 230 and inside the shield case 120'.
  • the switch probe 220 can be soldered thereto.
  • Figure 12 shows a perspective view of a first embodiment of a detector 8 in accordance with the present invention.
  • Fig. 13 shows the structure of the casing 80 of the detector 8 of Fig. 12, in which the holding structure 1 or 1' has been removed.
  • Detector 8 is used for accurate detection of non-invasive genes in liquid biopsy, for example, for detecting epidermal growth factor receptor mutations in cancer patients by detecting human body fluids in clinical or pathological laboratories.
  • the detector 8 can include a chassis 80 and a retention structure 1 according to a first embodiment of the present invention housed in the chassis 80.
  • the chassis 80 can also accommodate the retaining structure 1' in accordance with the second embodiment of the present invention.
  • the chassis 80 may include a chassis cover 810 and a case 820 that is open on the top side, and the chassis cover 810 may be rotatably attached to the chassis body 820, for example, by a hinge 801, and can sealingly close the chassis body 820 to form a sealed body. Interior space.
  • the casing body 820 may have a parallelepiped shape, but the present invention is not limited thereto, and the casing body 820 may have other suitable shapes according to actual needs.
  • the chassis 80 can further include a table 830 that can be fixed and covered on the top side of the casing 820 to form an internal volume with the casing 820 for accommodating the holding structure 1, 1' and related electronic devices, such as a motherboard. .
  • the mesa 830 can be a flat metal plate, for example having a rectangular shape, and includes a mesa opening 831 (eg, at the center of the mesa 830).
  • a mesa opening 831 eg, at the center of the mesa 830.
  • the perimeter of the mesa 830 is sealably secured to the side of the housing 820.
  • the chassis cover 810 and the chassis body 820 may also be made of a metal material to shield electromagnetic interference.
  • a viewing window 811 may be disposed on the chassis cover 810 to observe the state of the orifice plate 9 or 9' at any time.
  • the cover 810 may not be provided with the observation window 811, but a single metal part as a whole to enhance the electromagnetic shielding effect.
  • a power switch 821 and an indicator light 822 may be further disposed at a suitable position of the housing 820, and the indicator light 822 is used, for example, to indicate different operating conditions, indicate an orifice placement state, and the like.
  • the bottom of the casing body 820 may be provided with a plurality of retainer strut 823 (only one shown) extending inwardly for supporting and retaining the retainer 10 in the casing body 820.
  • FIG. 14 schematically illustrates how the retaining structure 1 or 1' is received in the housing body 820 and forms a sealing engagement with the table top 830.
  • the recess 104 on the retainer body 100, 100' of the retainer 10, 10' engages the countertop 830 by a seal 105 disposed therein.
  • a seal 105 such as a sealant ring, may be disposed between the inside of the vertical wall of the table top 830 and one of the side walls of the recess 104, thereby achieving a sealing engagement of the retainer 10, 10' with the chassis 80, effectively preventing The external environment interferes with components placed inside the chassis.
  • the holder 10" may include a holder body 100" having a receiving portion 110" capable of receiving an orifice plate.
  • the holder 10" may further include at least one probe module 200" disposed at a bottom portion 111 of the receiving portion 110" Similar to the probe module 200 in the first embodiment of the retention structure 1 according to the present invention, the probe module 200" may include a plurality of contact probes 210, at least one switch probe 220, and an electrically insulating plate 230.
  • the structure of the contact probe 210 and the switch probe 220 can be the same as previously described, and will not be described again here.
  • the retaining structure 1" may further include a pressure conversion plate 20", such as made of a metal material, which is mounted in the chassis of the detector 8A. 80A chassis cover 810A ( Figures 18 and 19). This will be detailed below.
  • the accommodating portion 110" may include a fence 140 that may protrude outward from the bottom portion 111" of the accommodating portion 110" to surround the orifice plate 9 and restrict its horizontal sliding.
  • Fig. 15B shows two possibilities of the fence 140 Form.
  • the form of the fence 140 is not limited to the examples shown in the figures.
  • the housing portion 110" is electrically insulated and integral with the electrically insulating plate 230.
  • the holder body 100" may be electrically insulated as a whole, such as a plastic material.
  • the holder body 100" may further include a closed annular wall 150 that protrudes outward from the holder body 100" and is located at the periphery of the fence 140.
  • the closed annular wall 150 can carry a seal 151, such as a sealing rubber ring.
  • the holder body 100" may further include an error-proof column 141 disposed at the bottom of the accommodating portion 110" and protruding outward from the accommodating portion 110".
  • a recess for receiving the error-proof column 141 may be provided, while the remaining portion is substantially flat.
  • Figure 16 shows the holder 10" seen from below.
  • the holder 10" may further comprise a support plate 400 supporting the holder body 100", which may be located below the holder body 100", for example to the holder
  • the bottom of the main body 100" is made of a metal material, thereby further strengthening the structural strength of the retainer while providing electromagnetic shielding.
  • the support plate 400 may be provided with a notch 401, the contact probe 210 and the switch probe 220 and the support plate 400 passes through the gap 401 without contact.
  • the support plate 400 can have a first side (not shown) facing the holder body 100" and a second side 402 facing away from the holder body, carrying control of the holder control circuit
  • a plate 130" (Fig. 19) is secured to the support plate 400 at a second side 402 of the support plate 400 and spaced apart from the support plate 400.
  • the pressure conversion plate 20" of the holding structure 1" will be described below with reference to Figs. 18 and 19 show a second embodiment 8A of the detector according to the present invention.
  • the detector 8A can include a chassis 80A that can include a chassis cover 810A and a chassis body 820A.
  • the orifice plate is located between the pressure conversion plate 20" and the bottom portion 111" of the accommodating portion 110".
  • the pressure conversion plate 20" can be rotatably mounted about the axis of symmetry A-A on the chassis cover 810A, such as through its axis 21" (Fig. 17B).
  • the axis of symmetry A-A can be parallel to the second axis X2-X2 around which the chassis cover 810A rotates relative to the chassis body 820A.
  • the chassis cover 810A may have a receiving portion 811A, and the pressure conversion plate 20" is received in the receiving portion 811A.
  • the configuration of the pressure conversion plate 20" may be as shown in FIG. 17B, which may have the form of a rectangular frame, but may not be The flat rectangular frame has a thicker thickness than the pressure conversion plate 20 in the first embodiment to accommodate the cover 810A having a larger thickness.
  • the operation of the pressure conversion plate 20" is the same as that of the pressure conversion plate 20, and will not be described again here.
  • the pressure conversion plate 20" and the chassis cover 810A may further include interengaging rotation blocking means.
  • a bar 22" may be disposed on an edge of the pressure conversion plate 20" parallel to the axis of symmetry AA, and the bar 22" may be The edge projects outwardly.
  • the chassis cover 810A includes a bar receiving portion 812A ( Figure 19).
  • the rotary blocking device having a mating form may have other forms than those described above, and may be disposed at other positions of the chassis cover 810A and the pressure conversion plate 20" as long as the pressure conversion plate 20" is limited relative to the chassis cover 810A. The relative rotation of the angle is sufficient.
  • a power switch 821A and an indicator light 822A may be disposed on the casing 820A.
  • the detector 8A may further include a panel 830A, which is, for example, a metal panel.
  • the chassis body 820A may include a first shield case 823A, a second shield case 824A, and a third shield case 825A, both of which are metal shield cases.
  • the first shield case 823A is disposed around the holder 10", and surrounds the holder body 100", the probe module 200", the control board 130 carrying the holder control circuit, and the like.
  • the second shield case 824A and the third shield case 825A The main control board 81A surrounding the first shield case 823A and the detector 8A is located outside the first shield case 823A.
  • the metal panel 830A, the holder support plate 400, the first shield case 823A, and the The second shield shell 824A and the third shield shell 825A can form a box-shaped shield to effectively electromagnetically shield the local current path on the control board and the probe.
  • chassis cover 810A When the chassis cover 810A is closed, its inner side is pressed against the seal 151 carried by the closed annular wall 150 on the retainer body 100" to achieve a sealing engagement between the retainer and the chassis 80A.
  • Figure 20 shows an embodiment of a detector 8A that includes a retention structure that can receive three 16-well orifice plates 9'. Accordingly, the chassis cover 810A can be mounted with three pressure conversion plates 20"'.
  • Fig. 21 shows another embodiment of the detector 8A which includes a holding structure for receiving a 16-hole orifice plate 9'. Accordingly, the chassis cover 810A can be mounted with a pressure conversion plate 20"'.

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  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Measurement Of Radiation (AREA)

Abstract

L'invention concerne une structure de retenue utilisée pour retenir une plaque de trou de détection d'échantillon, la plaque de trou de détection d'échantillon étant utilisée pour recevoir un échantillon devant être détecté et étant dotée d'une électrode, la structure de retenue comprenant un élément de retenue et une plaque de conversion de pression, l'élément de retenue comprenant un corps principal de retenue doté d'une partie de réception permettant de recevoir la plaque de trou de détection d'échantillon et un module de sonde agencé au niveau du fond de la partie de réception, la plaque de trou de détection d'échantillon étant située entre la plaque de conversion de pression et le module de sonde lorsqu'elle est reçue à l'intérieur de la partie de réception.
PCT/CN2017/105434 2016-08-11 2017-10-10 Structure de retenue et détecteur comprenant une structure de retenue WO2018028722A2 (fr)

Applications Claiming Priority (2)

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CN201610658321.X 2016-08-11
CN201610658321.XA CN106290476B (zh) 2016-08-11 2016-08-11 保持结构及包括保持结构的检测仪

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CN112680322A (zh) * 2021-01-29 2021-04-20 青岛汉唐生物科技有限公司 一种辅助加样及覆膜装置

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CN106290476B (zh) * 2016-08-11 2019-06-07 广州易活生物科技有限公司 保持结构及包括保持结构的检测仪
CN110118803A (zh) * 2018-02-07 2019-08-13 北京易活生物科技有限公司 样本检测装置
CN110806309B (zh) * 2018-08-03 2022-03-08 施耐德电器工业公司 用于接触器的测试装置
CN112992599B (zh) * 2019-12-13 2023-02-17 天津平高智能电气有限公司 真空灭弧室真空度测量装置
CN114785427B (zh) * 2022-03-09 2024-01-30 昆山浩兴电子科技有限公司 一种便携式的wifi信号检测装置

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JPS6057259A (ja) * 1983-09-09 1985-04-03 Konishiroku Photo Ind Co Ltd 生化学分析装置
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CN201096804Y (zh) * 2007-07-10 2008-08-06 翔宏兴业有限公司 一种芯片测试装置
CN201194023Y (zh) * 2008-04-07 2009-02-11 比亚迪股份有限公司 一种集成电路测试装置
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CN106290476B (zh) * 2016-08-11 2019-06-07 广州易活生物科技有限公司 保持结构及包括保持结构的检测仪

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CN112680322A (zh) * 2021-01-29 2021-04-20 青岛汉唐生物科技有限公司 一种辅助加样及覆膜装置

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WO2018028722A3 (fr) 2018-04-12
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