WO2018026087A3 - 당 부가된 엔클로미펜, 이의 제조방법 및 이를 포함하는 약학적 조성물 - Google Patents

당 부가된 엔클로미펜, 이의 제조방법 및 이를 포함하는 약학적 조성물 Download PDF

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Publication number
WO2018026087A3
WO2018026087A3 PCT/KR2017/004022 KR2017004022W WO2018026087A3 WO 2018026087 A3 WO2018026087 A3 WO 2018026087A3 KR 2017004022 W KR2017004022 W KR 2017004022W WO 2018026087 A3 WO2018026087 A3 WO 2018026087A3
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WO
WIPO (PCT)
Prior art keywords
enclomiphene
sugar
added
preparation
pharmaceutical composition
Prior art date
Application number
PCT/KR2017/004022
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English (en)
French (fr)
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WO2018026087A2 (ko
Inventor
박제원
Original Assignee
고려대학교 산학협력단
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 고려대학교 산학협력단 filed Critical 고려대학교 산학협력단
Publication of WO2018026087A2 publication Critical patent/WO2018026087A2/ko
Publication of WO2018026087A3 publication Critical patent/WO2018026087A3/ko

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18—Acyclic radicals, substituted by carbocyclic rings

Abstract

본 발명에 따른 화학식 1의 화합물 또는 이의 약학적으로 허용가능한 염은 에스트로겐 수용체α(ERα)에 길항 활성을 유지하면서 생체이용률을 향상시키는 효과가 있는 당부가 엔클로미펜 유도체들로서, 골다공증(osteoporosis), 갱년기성 질 위축증(vaginal atrophy), 성교불쾌증(dyspareunia), 여유증(gynecomastia), 남성 이차 성선기능저하증 및 인슐린 비의존성 당뇨병 혹은 지방이영양증, 불임증, 남성전립선비대증, 전립선암, 난소암, 유방암 등의 에스트로겐 수용체 관련 질환을 치료할 수 있는 프로드럭 혹은 대체 개량 제형으로서 유용하게 사용될 수 있다.
PCT/KR2017/004022 2016-08-05 2017-04-13 당 부가된 엔클로미펜, 이의 제조방법 및 이를 포함하는 약학적 조성물 WO2018026087A2 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2016-0100098 2016-08-05
KR1020160100098A KR101970326B1 (ko) 2016-08-05 2016-08-05 당 부가된 엔클로미펜, 이의 제조방법 및 이를 포함하는 약학적 조성물

Publications (2)

Publication Number Publication Date
WO2018026087A2 WO2018026087A2 (ko) 2018-02-08
WO2018026087A3 true WO2018026087A3 (ko) 2018-08-09

Family

ID=61074169

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2017/004022 WO2018026087A2 (ko) 2016-08-05 2017-04-13 당 부가된 엔클로미펜, 이의 제조방법 및 이를 포함하는 약학적 조성물

Country Status (2)

Country Link
KR (1) KR101970326B1 (ko)
WO (1) WO2018026087A2 (ko)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001027127A1 (en) * 1999-10-08 2001-04-19 Strakan Group Plc Tamoxifen and tamoxifen analogue glycosides and uses thereof
KR20010108719A (ko) * 2000-05-31 2001-12-08 추후보정 유방암의 예방 또는 치료용 조성물 및 그 예방 또는 치료방법
WO2009035652A1 (en) * 2007-09-13 2009-03-19 Concert Pharmaceuticals, Inc. Synthesis of deuterated catechols and benzo[d][1,3] dioxoles and derivatives thereof
KR20170011543A (ko) * 2015-07-23 2017-02-02 고려대학교 산학협력단 당전이 효소를 이용한 당 부가된 에스트로겐 수용체 조절제의 제조방법

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001027127A1 (en) * 1999-10-08 2001-04-19 Strakan Group Plc Tamoxifen and tamoxifen analogue glycosides and uses thereof
KR20010108719A (ko) * 2000-05-31 2001-12-08 추후보정 유방암의 예방 또는 치료용 조성물 및 그 예방 또는 치료방법
WO2009035652A1 (en) * 2007-09-13 2009-03-19 Concert Pharmaceuticals, Inc. Synthesis of deuterated catechols and benzo[d][1,3] dioxoles and derivatives thereof
KR20170011543A (ko) * 2015-07-23 2017-02-02 고려대학교 산학협력단 당전이 효소를 이용한 당 부가된 에스트로겐 수용체 조절제의 제조방법

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MCCAGUE, R.: "Metabolism of tamoxifen by isolated rat hepatocytes: Identification of the glucuronide of 4-hydroxytamoxifen", BIOCHEMICAL PHARMACOLOGY, 1 May 1990 (1990-05-01), pages 1459 - 1465, XP025521625 *

Also Published As

Publication number Publication date
KR101970326B1 (ko) 2019-04-18
KR20180016108A (ko) 2018-02-14
WO2018026087A2 (ko) 2018-02-08

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