WO2018011583A3 - Scanning microsphere lens nanoscope - Google Patents

Scanning microsphere lens nanoscope Download PDF

Info

Publication number
WO2018011583A3
WO2018011583A3 PCT/GB2017/052061 GB2017052061W WO2018011583A3 WO 2018011583 A3 WO2018011583 A3 WO 2018011583A3 GB 2017052061 W GB2017052061 W GB 2017052061W WO 2018011583 A3 WO2018011583 A3 WO 2018011583A3
Authority
WO
WIPO (PCT)
Prior art keywords
microsphere
sample
control beam
nanoscope
scanning
Prior art date
Application number
PCT/GB2017/052061
Other languages
French (fr)
Other versions
WO2018011583A2 (en
Inventor
Sorin STANESCU
Wei Guo
Lin Li
Original Assignee
LIG Nanowise Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LIG Nanowise Limited filed Critical LIG Nanowise Limited
Publication of WO2018011583A2 publication Critical patent/WO2018011583A2/en
Publication of WO2018011583A3 publication Critical patent/WO2018011583A3/en

Links

Classifications

    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/32—Micromanipulators structurally combined with microscopes
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/02—Objectives
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/36—Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements
    • G02B21/362—Mechanical details, e.g. mountings for the camera or image sensor, housings
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/36—Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements
    • G02B21/365—Control or image processing arrangements for digital or video microscopes
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B27/00—Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00
    • G02B27/58—Optics for apodization or superresolution; Optical synthetic aperture systems
    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21K—TECHNIQUES FOR HANDLING PARTICLES OR IONISING RADIATION NOT OTHERWISE PROVIDED FOR; IRRADIATION DEVICES; GAMMA RAY OR X-RAY MICROSCOPES
    • G21K1/00—Arrangements for handling particles or ionising radiation, e.g. focusing or moderating
    • G21K1/006—Manipulation of neutral particles by using radiation pressure, e.g. optical levitation

Abstract

An apparatus (1) for super resolution microscopy comprises a microscope (10) provided in position to capture an image of a sample (20). A microsphere (13) is provided between the sample (20) and the objective lens (11) to provide super resolution microscopy performance. To control the position of the microsphere (13), a control beam (45) captures the microsphere (13) and holds it in position by the optical tweezer effect. In order that it does not impact upon imaging carried out in the visible region of the spectrum the control beam (45) is in the infrared region of the spectrum. By varying the power of the control beam (45), the radiation pressure may be varied and the thus the separation between the sample and the microsphere may be varied. This can in turn vary the properties of images captured using a camera (15) attached to the microscope.
PCT/GB2017/052061 2016-07-14 2017-07-13 Scanning microsphere lens nanoscope WO2018011583A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB1612255.8 2016-07-14
GBGB1612255.8A GB201612255D0 (en) 2016-07-14 2016-07-14 Scanning microsphere lens nanoscope

Publications (2)

Publication Number Publication Date
WO2018011583A2 WO2018011583A2 (en) 2018-01-18
WO2018011583A3 true WO2018011583A3 (en) 2018-02-15

Family

ID=56890430

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2017/052061 WO2018011583A2 (en) 2016-07-14 2017-07-13 Scanning microsphere lens nanoscope

Country Status (2)

Country Link
GB (2) GB201612255D0 (en)
WO (1) WO2018011583A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108469686A (en) * 2018-06-20 2018-08-31 大连理工大学 A kind of optical ultra-discrimination rate imaging system based on optical tweezer and microsphere lens
CN108873294A (en) * 2018-07-10 2018-11-23 长沙健金电子技术有限公司 A kind of optical tweezer trapped particle of double excitation or the device of cell
CN111381355B (en) * 2018-12-29 2022-08-02 北京雅谱光仪科技有限公司 Optical imaging apparatus and method
CN110927879A (en) * 2019-11-04 2020-03-27 桂林电子科技大学 Nano optical jet scanning probe based on optical fiber tweezers
CN112903542B (en) * 2021-01-18 2021-12-14 南京航空航天大学 Microsphere open type piezoelectric micro-control measurement system and method based on standing wave sound field

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100245816A1 (en) * 2009-03-27 2010-09-30 Renishaw Plc Near-field Raman spectroscopy

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10126546B2 (en) * 2013-01-29 2018-11-13 The Regents Of The University Of California Drift-corrected, high-resolution optical trap and high-sensitivity angular interferometer
WO2014120844A1 (en) * 2013-01-29 2014-08-07 The Regents Of The University Of California Drift-corrected, high-resolution optical trap and high-sensitivity angular interferometer

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100245816A1 (en) * 2009-03-27 2010-09-30 Renishaw Plc Near-field Raman spectroscopy

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ALEKSEI R. FAUSTOV ET AL: "Highly multiplexed scanning nanoscopic imaging", PROCEEDINGS OPTICAL DIAGNOSTICS OF LIVING CELLS II, vol. 5331, 1 June 2004 (2004-06-01), US, pages 21, XP055421737, ISSN: 0277-786X, ISBN: 978-1-5106-1354-6, DOI: 10.1117/12.531635 *
LEONID A. KRIVITSKY ET AL: "Locomotion of microspheres for super-resolution imaging", SCIENTIFIC REPORTS, vol. 3, no. 1, 16 December 2013 (2013-12-16), XP055421834, DOI: 10.1038/srep03501 *

Also Published As

Publication number Publication date
GB2553652A (en) 2018-03-14
GB201711268D0 (en) 2017-08-30
GB201612255D0 (en) 2016-08-31
WO2018011583A2 (en) 2018-01-18

Similar Documents

Publication Publication Date Title
WO2018011583A3 (en) Scanning microsphere lens nanoscope
WO2011049608A3 (en) Imaging system and techniques
EP2683154A3 (en) Image pickup apparatus and lens apparatus
JP2017006330A5 (en)
EP4235254A3 (en) Real-time focusing in line scan imaging
GB2558479A (en) Motorized full field adaptive microscope
JP2012506066A5 (en)
EP3010393A1 (en) Optimized imaging apparatus for iris imaging
WO2011005783A3 (en) Image-based surface tracking
EP3333614A3 (en) Image capturing apparatus and image capturing method
JP2015029865A5 (en) Image processing apparatus and method, fundus image processing apparatus, and fundus image photographing apparatus
EP2913992A3 (en) Image capturing apparatus, image capturing system, and image capturing method
JP2019505836A5 (en)
JP2011530094A5 (en)
WO2015051282A3 (en) Xslit camera
CN203502666U (en) CCD conversion interface lens
JP2017011504A5 (en)
JP2010191080A5 (en)
EP4303639A3 (en) Focusing device, microscope device, focusing method, and control program
JP2016018116A5 (en)
CN106773103A (en) A kind of zoom lens focal plane position fast determination method
JP2018180296A5 (en)
JP2014192745A5 (en)
EP3547002A3 (en) Lens apparatus and image pickup apparatus
JP2016213616A5 (en) Imaging apparatus and imaging control method

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 17754444

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 17754444

Country of ref document: EP

Kind code of ref document: A2