WO2017219323A1 - 一种试剂管 - Google Patents
一种试剂管 Download PDFInfo
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- WO2017219323A1 WO2017219323A1 PCT/CN2016/086939 CN2016086939W WO2017219323A1 WO 2017219323 A1 WO2017219323 A1 WO 2017219323A1 CN 2016086939 W CN2016086939 W CN 2016086939W WO 2017219323 A1 WO2017219323 A1 WO 2017219323A1
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- tube
- cover body
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- connecting section
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
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- B01L3/14—
Definitions
- the invention relates to the field of biotechnology, and in particular to a reagent tube.
- Biological reagents are mostly biological materials or organic compounds used in life science research, as well as reagents for clinical diagnosis and medical research, and have high requirements for purity. Before use, most biological reagents undergo storage, transfer or pretreatment processes, and the above processes tend to deteriorate the biological reagents and reduce their purity. Therefore, in order to prevent the purity of the biological agent from being lowered in the above process, it is necessary to provide a reagent-containing container which is highly sealed, has good storage properties, and is easy to handle.
- a sterilized clamshell reagent tube and a screw-on reagent tube are generally used as reagent storage containers, wherein the clamshell reagent tube includes a tube body and an opening and closing cover body disposed at the top of the tube body, and is turned up or down. Cover the lid to open or close the clamshell reagent tube.
- the screw-on reagent tube includes a tube body and a lid threadedly coupled to the tube body, and the screw-down reagent tube is opened or closed by screwing the lid body clockwise or counterclockwise.
- each component When the biological agent comprises two components, such as a lyophilized powder component and a solvent component, and is required to be ready to use, each component must be separately stored in a separate reagent tube during storage, and each component is used at the time of use. It must be thoroughly mixed in the same reagent tube or other container, which requires the secondary transfer of at least one of the components.
- the reagent tube provided by the prior art to store the reagents, it is necessary to separate each component into a separate reagent tube and mix it during use, which not only increases the human and material cost, but also ensures the mixing process. It is carried out under aseptic conditions, otherwise it is highly susceptible to contamination of the reagents due to exposure to an external environment.
- the technical problem to be solved by the embodiments of the present invention is to provide a biological reagent suitable for including two components and required to be ready to use, and the operation is convenient, the sealing property is good, and the reagent component is prevented from contacting the external source during the mixing process.
- Environmental reagent tube The specific technical solutions are as follows:
- a reagent tube comprising: a tube body open at both ends, an upper cover body, a lower cover body, a sealing member and a removable annular member;
- the tube body includes an outer tube and an inner tube, the outer tube includes an upper connecting section, a middle supporting section and a lower connecting section which are sequentially connected, and the inner tube is disposed in the middle supporting section;
- Two of the sealing members are respectively disposed at the cover of the upper cover and the lower cover to form a sealed receiving chamber in the upper cover and the lower cover;
- Two of the removable annular members are respectively disposed at a top of the upper connecting section and a bottom of the lower connecting section;
- the inner wall of the upper connecting section and the lower connecting section are respectively provided with internal threads, and the lower end of the upper cover body and the outer wall of the upper end of the lower cover body are respectively provided with the outer thread a threaded portion, the upper cover body and the upper connecting section and the lower cover body and the lower connecting section are screwed together, and when the removable annular component is removed, the upper cover body Both the lower cover and the lower cover can be further spirally moved, and the nozzle of the inner tube applies pressure to the two sealing members to rupture the sealing member.
- the reagent tube further comprises: a blocking member, the two blocking members being respectively disposed on the outer walls of the upper cover body and the lower cover body for abutting against the removable annular member contact.
- the blocking member is an annular flange that protrudes outward in the radial direction of the upper cover body and the lower cover body.
- the inner tube includes an upper piercing segment, a middle connecting segment and a lower piercing segment that are sequentially connected, the middle connecting segment and the middle supporting segment being fixed together by a connecting member, the upper piercing segment and the upper piercing segment A gap is provided between the upper connecting section and the lower piercing section and the lower connecting section for accommodating the walls of the upper cover and the cover of the lower cover.
- the outer tube and the inner tube are concentrically disposed, and the upper piercing segment and the lower piercing segment are both tubular bodies having a constant outer diameter and a variable inner diameter, and the upper piercing segment is The inner diameter gradually increases from the bottom, and the inner diameter of the lower piercing section gradually increases from top to bottom.
- the outer diameter of the upper piercing section is equal to the inner diameter of the upper cover body, and the outer diameter of the lower piercing section is equal to the inner diameter of the lower cover body.
- an elastic coating is disposed on the outer wall of the upper piercing section and the lower piercing section.
- the upper piercing section and the lower piercing section are provided with a sealing ring on an outer wall of the end of the middle connecting section.
- the outer wall of the outer tube is provided with an anti-slip structure.
- the material of the tube body, the upper cover body and the lower cover body are medical grade polymers
- the material of the sealing member is selected from medical grade metal foil.
- the reagent tube provided by the embodiment of the invention when used for containing the two-component biological reagent, can be sealed and placed in the upper cover body and the lower cover body respectively, and is screwed with the tube body portion to form a single body. Reagent tube.
- the upper cover and the lower cover are further rotated to move toward the inner tube nozzle by removing the removable annular member until the nozzle of the inner tube applies to the two sealing members.
- the pressure is such that the closure member is broken, and the components in the upper cover and the lower cover are sufficiently mixed to achieve ready-to-use.
- the reagent tube provided by the embodiment of the invention can simultaneously carry two components such as lyophilized powder and a solvent, and can be mixed without opening when used, so that not only the human and material cost is reduced, but also the operation convenience is improved.
- the sealing property is ensured, and the secondary pollution caused by the reagent contacting the external environment during mixing is avoided, which is more safe and reliable.
- 1-1 is a front view of a reagent tube according to an embodiment of the present invention.
- 1-2 is a cross-sectional view of a reagent tube according to still another embodiment of the present invention.
- 2-1 is a front view of a tube body of a reagent tube according to still another embodiment of the present invention.
- FIG. 2-2 is a cross-sectional view showing a tube body of a reagent tube according to still another embodiment of the present invention.
- 3-1 is a front view of an upper cover body of a reagent tube according to still another embodiment of the present invention.
- 3-2 is a cross-sectional view of an upper cover body of a reagent tube according to still another embodiment of the present invention.
- the embodiment of the present invention provides a reagent tube, as shown in FIG. 1-1 and FIG. 1-2, the reagent tube includes: a tube body 1 with open ends, an upper cover body 2, a lower cover body 3, and a sealing mouth. Piece 4 and a removable annular member 5.
- the pipe body 1 includes an outer pipe 101 and an inner pipe 102
- the outer pipe 101 includes an upper connecting section 1011, a middle supporting section 1012 and a lower connecting section 1013 which are sequentially connected
- the inner tube 102 is disposed in the middle supporting section 1012.
- Two sealing members 4 are respectively disposed at the nozzles of the upper cover 2 and the lower cover 3 to form a closed accommodating chamber in the upper cover 2 and the lower cover 3.
- Two removable annular members 5 are disposed at the top of the upper connecting section 1011 and the bottom of the lower connecting section 1013, respectively.
- internal threads 103 are provided on the inner walls of the upper connecting portion 1011 and the lower connecting portion 1013 of the outer tube 101, and the lower end and the lower cover 3 of the upper cover 2 are provided.
- the outer wall of the upper end is provided with an external thread 201 which cooperates with the internal thread 103.
- the structure of the upper external thread 201 can be seen in FIG. 3-1 and FIG. 3-2.
- the upper cover 2 and the upper connecting portion 1011 and the lower cover 3 and the lower connecting portion 1013 are screwed together.
- the nozzle of the inner tube 102 applies pressure to the two closure members 4 to rupture the closure member 4.
- the reagent tube provided by the embodiment of the present invention when used for containing the two-component biological reagent, can be sealed and placed in the upper cover body 2 and the lower cover body 3 respectively, and is screwed with the pipe body 1 portion.
- a separate reagent tube When the biological reagent is used, the upper cover 2 and the lower cover 3 are further rotated to move in the direction of the nozzle of the inner tube 102 by removing the removable annular member 5 until the nozzle pair of the inner tube 102
- the two closure members 4 apply pressure to rupture the closure member 4, at which time the components in the upper cover 2 and the lower cover 3 will be thoroughly mixed for immediate use.
- the reagent tube provided by the embodiment of the invention can simultaneously carry two components such as lyophilized powder and a solvent, and can be mixed without opening when used, so that not only the human and material cost is reduced, but also the operation convenience is improved.
- the sealing property is ensured, and the secondary pollution caused by the reagent contacting the external environment during mixing is avoided, which is more safe and reliable.
- the reagent tube provided by the embodiment of the invention not only can effectively solve the above problems, but also ensures the quality of the reagent, and avoids marking the same batch of components in the dispensing process, thereby realizing high precision and efficient dispensing inside the factory.
- the reagent tube provided by the embodiment of the present invention can be used not only for storage and mixing of biological reagents, but also for other products such as beverages and health care products that are ready-to-use when changing the size thereof.
- the embodiment of the present invention provides that the two annular members 5 are respectively disposed at the top of the upper connecting portion 1011 and the bottom of the lower connecting portion 1013, and the function is that when the annular member 5 exists When the upper cover body 2 and the upper connecting portion 1011 and the lower cover body 3 and the lower connecting portion 1013 are only partially threaded, that is, a complete fit cannot be achieved; and when the annular member 5 is removed, the upper portion is removed.
- the cover body 2 and the lower cover body 3 are further rotatable to move in the direction of the nozzle of the inner tube 102 until the upper cover body 2 and the upper connection section 1011 and the lower cover body 3 and the lower connection section 1013 are completely threaded, and At this time, the nozzle at the upper and lower ends of the inner tube 102 can apply pressure to the sealing member 4 on the upper cover 2 and the lower cover 3 to break (this also determines the width of the annular member 5).
- the embodiment of the present invention uses the upper cover 2 and the lower cover 3 as a container for the reagent, and adjusts the internal volume of the upper cover 2 and the lower cover 3 according to the amount of the reagent contained, and the upper cover 2 and the internal volume of the lower cover 3 may be the same or different, and the embodiment of the present invention does not specifically limit it.
- the embodiment of the invention seals the openings of the upper cover 2 and the lower cover 3 by sealing the closure member 4 such that they form a containment container having a sealed containment chamber.
- the structure of the sealing member 4 preferably coincides with the opening of the upper cover 2 and the lower cover 3, and after the reagent is loaded into the upper cover 2 and the lower cover 3, the sealing member 4 is joined by thermocompression bonding, gluing or the like. Fixed in their openings.
- the reagent tube provided by the embodiment of the present invention further includes two blocking members 6, and the two blocking members 6 are respectively disposed on the upper cover body 2 and the lower cover body.
- the outer wall of the third wall is for coming into contact with the removable annular member 5.
- the blocking member 6 is an annular flange that protrudes outward in the radial direction of the upper cover body 2 and the lower cover body 3, so that it can be brought into contact with the removable annular member 5 as a whole.
- the blocking member 6 may also be a plurality of bumps that protrude outward in the radial direction of the upper cover body 2 and the lower cover body 3.
- the inner tube 102 includes an upper piercing section 1021, a middle connecting section 1022 and a lower piercing section 1023 which are sequentially connected, wherein the inner tube
- the middle connecting section 1022 of the 102 and the middle supporting section 1012 of the outer tube 101 are fixed together by a connecting member 7, which may be fixed at both ends to the middle connecting section 1022 of the inner tube 102 and the middle supporting section of the outer tube 101, respectively.
- a gap is provided between the upper piercing section 1021 of the inner tube 102 and the upper connecting section 1011 of the outer tube 101 and the lower piercing section 1023 of the inner tube 102 and the lower connecting section 1013 of the outer tube 101, the gap being used for housing
- the walls of the nozzles of the cover 2 and the lower cover 3 are such that their nozzles enter the gap when the upper cover 2 and the lower cover 3 are further rotated, ensuring that the closure member 4 can be broken by the nozzle of the inner tube 102 .
- the tubular body 1 is an upper and lower transparent double cylinder structure composed of an outer tube 101 and an inner tube 102, and preferably, the outer tube 101 and the inner tube
- the 102 is concentrically arranged and integrally formed, so that the safety seal of the pipe body 1 can be ensured.
- the upper cover 2, the lower cover 3 and the removable annular member 5 can be produced using a separate mold in conjunction with the structure of the tubular body 1. Further, the upper cover 2 and the lower cover 3 preferably have the same inner diameter to facilitate the manufacture of the reagent tube.
- the upper piercing section 1021 and the lower piercing section 1023 are both the tube body 1 whose outer diameter is constant and the inner diameter is variable, and the inner diameter of the upper piercing section 1021 is gradually increased from the bottom to the top.
- the inner diameter of the lower puncture section 1023 gradually increases from top to bottom.
- the inner diameters of the upper puncture segment 1021 and the lower puncture segment 1023 are controlled to be variable so that the wall thickness at the lower end of the upper puncture segment 1021 and the lower end of the lower puncture segment 1023 is minimized, which is advantageous for piercing the closure member 4.
- Controlling the upper end of the upper puncture section 1021 in the inner tube 102 according to the material of the sealing member 4 used The wall thickness at the lower end of the lower piercing section 1023 is as long as the sealing member 4 can be pierced by the specific pressure.
- the outer diameters of the upper piercing section 1021 and the lower piercing section 1023 should be less than or equal to the upper cover. 2 and the inner diameter of the lower cover 3.
- the outer diameter of the upper piercing section 1021 is equal to the inner diameter of the upper cap body 2, and the outer diameter of the lower piercing section 1023. It is equal to the inner diameter of the lower cover 3, that is, the upper piercing section 1021 and the lower piercing section 1023 can enter the upper cover body 2 and the lower cover body 3, respectively, and there is no gap between them.
- a thin layer may be disposed on the outer wall of the upper piercing section 1021 and the lower piercing section 1023, for example, a thickness of 0.5-1 mm.
- the left and right elastic coatings or the seal outer ring on the outer wall of the upper piercing section 1021 and the lower piercing section 1023 adjacent to the middle connecting section 1022 so that the inner tube 102 enters the upper cover body 2 and the lower cover body 3 while entering each other It can be more closely coordinated to ensure that all lyophilized powder and solvent are completely mixed together to ensure the quality of biological reagents.
- the anti-slip structure 8 is disposed on the outer wall of the outer tube 101 to improve the friction between the outer tube 101 and the operator's hand, so that the rotation of the upper cover 2 and the lower cover 3 is more labor-saving.
- the anti-slip structure 8 can be realized by treating the outer wall of the outer tube 101 to form an anti-slip texture thereon, such as a threaded structure, a staggered linear structure, or other geometric shape.
- the removable annular member 5 is common in the art, for example, it may be a tearable pull ring, and the pull ring may be fixed to the outer tube 101 through a plurality of connecting posts.
- the upper edge of the upper connecting section 1011 and the lower edge of the lower connecting section 1013 also have an opening, and a pull tab is provided on one side of the opening.
- the removable annular member 5 in the embodiment of the present invention is a snap ring with an opening on one side.
- the reagent tube provided by the embodiment of the present invention should be strictly sterilized, and the preparation process of the reagent tube should be performed under aseptic conditions to ensure that the inside of the reagent tube is a sterile environment.
- the material of the tube 1, the upper cover 2, the lower cover 3, and the removable annular member 5 are all medical grade polymers, such as medical grade polypropylene, polyethylene, acrylic copolymer, cyclic olefin. Copolymer, transparent polyamide, etc., the material has stable performance and is not easily affected by the external environment. Deterioration ensures that the reagents contained in it will not deteriorate.
- the material of the sealing member 4 is selected from medical grade metal foils, such as aluminum foil, etc., and the materials are stable in performance and are easily pierced under a certain pressure.
- the reagent tubes When used to hold reagents, such as lyophilized powders and vehicles, the reagent tubes are first sterilized to achieve medical grade. The solvent and lyophilized powder are then optionally placed in the upper lid body 2 and the lower lid body 3 under aseptic conditions, and then the upper lid body 2 and the lower lid body 3 are sealed by a sealing member 4 such as a sealing aluminum foil. Finally, the upper cover 2 and the lower cover 3 are screw-fitted to the outer tube 101 until the blocking member 6 thereon comes into contact with the removable annular member 5. At this point, the reagents can be stored.
- a sealing member 4 such as a sealing aluminum foil
- the removable annular member 5 is removed, and then the upper cover 2 and the lower cover 3 are continuously rotated until they are fully threaded with the outer tube 101 so that the nozzle of the inner tube 102 pierces the upper cover
- the sealing member 4 on the body 2 and the lower cover 3 at this time, the lyophilized powder and the solvent can be mixed together, and the reagent tubes can be sufficiently shaken to sufficiently mix them.
- the upper lid body 2 or the lower lid body 3 may be optionally opened to take out the mixed reagent.
- the reagent tube provided by the embodiment of the invention realizes the use of a reagent tube to simultaneously carry the lyophilized powder and the solvent through the above-mentioned two-in-one design. In use, it is not necessary to open the reagent tube, and it is possible to achieve thorough mixing without contacting the external environment, thereby avoiding secondary pollution of the reagent.
- the reagent tube reduces various manpower and material costs such as production, transportation and disinfection, and has convenient operation, good sealing performance, high safety, and is convenient for large-scale popularization and application.
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Abstract
一种试剂管，包括：两端开口的管体（1）、上盖体（2）、下盖体（3）、封口件（4）以及可移除的环状部件（5）；管体（1）包括外管（101）和内管（102），外管（101）包括顺次连通的上连接段（1011）、中支撑段（1012）和下连接段（1013），内管（102）设置在中支撑段（1012）内；两个封口件（4）分别设置在上盖体（2）和下盖体（3）的盖口处，以在上盖体（2）和下盖体（3）内形成密闭的容置腔体；两个可移除的环状部件（5）分别设置在上连接段（1011）顶部和下连接段（1013）底部；上连接段（1011）和下连接段（1013）的内壁上均设置有内螺纹（103），上盖体（2）的下端与下盖体（3）的上端的外壁上均设置有与内螺纹（103）相配合的外螺纹（201），上盖体（2）与上连接段（1011）以及下盖体（3）与下连接段（1013）之间均螺纹连接。
Description
本发明涉及生物技术领域，特别涉及一种试剂管。
生物试剂多为用于生命科学研究的生物材料或有机化合物，以及用于临床诊断、医学研究的试剂，对其纯度的要求较高。而在使用之前，多数生物试剂会经历存储、转移或预处理等过程，而上述过程均易使生物试剂发生变质，降低其纯度。所以，为了防止生物试剂在上述过程中纯度降低，有必要提供一种密封性强、储存性好且便于操作的试剂盛装容器。
现有技术通常采用消毒处理的翻盖式试剂管和旋拧式试剂管作为试剂盛装容器，其中，翻盖式试剂管包括管体和设置在管体顶部的开合式盖体，通过上翻或者下合盖体，来打开或者封闭该翻盖式试剂管。旋拧式试剂管包括管体和与所述管体螺纹连接的盖体，通过顺时针或者逆时针旋拧盖体来打开或关闭该旋拧式试剂管。
发明人发现现有技术至少存在以下问题：
当生物试剂包括双组分，例如冻干粉组分和溶媒组分，且要求即配即用时，在存储过程中各组分须在单独的试剂管中分别存储，而在使用时各组分须在同一试剂管或者其他容器中充分混合，这就需要将其中至少一种组分进行二次转移。而采用现有技术提供的试剂管存储该类试剂，需要使每种组分分装在一个单独的试剂管中，在使用时再进行混合，如此不仅会增加人力物力成本，而且要保证混合过程在无菌条件下进行，否则极易因接触外源环境而对试剂造成污染。
发明内容
本发明实施例所要解决的技术问题在于，提供了一种适用于包括双组分且要求即配即用的生物试剂，且操作便利，密封性好，避免试剂组分在混合过程中接触外源环境的试剂管。具体技术方案如下：
一种试剂管，所述试剂管包括：两端开口的管体、上盖体、下盖体、封口件以及可移除的环状部件；
所述管体包括外管和内管，所述外管包括顺次连通的上连接段、中支撑段和下连接段，所述内管设置在所述中支撑段内；
两个所述封口件分别设置在所述上盖体和所述下盖体的盖口处，以在所述上盖体和所述下盖体内形成密闭的容置腔室；
两个所述可移除的环状部件分别设置在所述上连接段顶部和所述下连接段底部；
所述上连接段和所述下连接段的内壁上均设置有内螺纹，所述上盖体的下端与所述下盖体的上端的外壁上均设置有与所述内螺纹相配合的外螺纹，所述上盖体与所述上连接段以及所述下盖体与所述下连接段之间均螺纹连接，当移除所述可移除的环状部件后，所述上盖体和所述下盖体均能够进一步螺旋运动，所述内管的管口对两个所述封口件施加压力以使所述封口件破裂。
作为优选，所述试剂管还包括：阻挡件，两个所述阻挡件分别设置在所述上盖体和所述下盖体的外壁上，用于与所述可移除的环状部件相抵接触。
具体地，所述阻挡件为沿所述上盖体和所述下盖体的径向向外凸出的环状凸缘。
具体地，所述内管包括顺次连通的上穿刺段、中连接段和下穿刺段，所述中连接段与所述中支撑段通过连接件固定在一起，所述上穿刺段与所述上连接段以及所述下穿刺段与所述下连接段之间设置有间隙，所述间隙用于容纳所述上盖体和所述下盖体的盖口的壁。
具体地，作为优选，所述外管和所述内管同心设置，所述上穿刺段和所述下穿刺段均为外径不变而内径可变的管体，且所述上穿刺段的内径由下自上逐渐增大，所述下穿刺段的内径由上至下逐渐增大。
作为优选，所述上穿刺段的外径等于所述上盖体的内径，所述下穿刺段的外径等于所述下盖体的内径。
可选地，所述上穿刺段和下穿刺段的外壁上设置有一层弹性涂层。
可选地，所述上穿刺段和下穿刺段靠近所述中连接段的端部外壁上套装有密封圈。
具体地，作为优选，所述外管的外壁上设置有防滑结构。
具体地，所述管体、所述上盖体、所述下盖体的材质均为医疗级聚合物；
所述封口件的材质选自医疗级金属箔。
本发明实施例提供的技术方案带来的有益效果是：
本发明实施例提供的试剂管，在用于盛装双组份生物试剂时，可将该双组份分别密封放置于上盖体和下盖体内，并和管体部分螺纹连接，以形成一个单独的试剂管。而在使用生物试剂时，通过移除可移除的环状部件，进一步旋转上盖体和下盖体使其向着内管管口的方向运动，直至内管的管口对两个封口件施加压力以使封口件破裂，此时上盖体和下盖体内的组分将充分混合，实现即配即用。可见，本发明实施例提供的试剂管可同时承载诸如冻干粉和溶媒之类的两种组分，且使用时无需打开即可混合，如此不仅降低了人力物力成本，提高了操作便利性，且保证了其密封性，避免了试剂在混合时接触外源环境而造成二次污染，更加安全可靠。
为了更清楚地说明本发明实施例中的技术方案，下面将对实施例描述中所需要使用的附图作简单地介绍，显而易见地，下面描述中的附图仅仅是本发明的一些实施例，对于本领域普通技术人员来讲，在不付出创造性劳动的前提下，还可以根据这些附图获得其他的附图。
图1-1是本发明实施例提供的试剂管的主视图；
图1-2是本发明又一实施例提供的试剂管的剖面图；
图2-1是本发明又一实施例提供的试剂管的管体的主视图；
图2-2是本发明又一实施例提供的试剂管的管体的剖面图；
图3-1是本发明又一实施例提供的试剂管的上盖体的主视图；
图3-2是本发明又一实施例提供的试剂管的上盖体的剖面图。
附图标记分别表示：
1 管体，
101 外管，
1011 上连接段，
1012 中支撑段，
1013 下连接段，
102 内管，
1021 上穿刺段，
1022 中连接段，
1023 下穿刺段，
103 内螺纹，
2 上盖体，
201 外螺纹，
3 下盖体，
4 封口件，
5 环状部件，
6 阻挡件，
7 连接件，
8 防滑结构。
为使本发明的目的、技术方案和优点更加清楚，下面将结合附图对本发明实施方式作进一步地详细描述。
本发明实施例提供了一种试剂管，如附图1-1及附图1-2所示，该试剂管包括：两端开口的管体1、上盖体2、下盖体3、封口件4以及可移除的环状部件5。其中，管体1包括外管101和内管102，外管101包括顺次连通的上连接段1011、中支撑段1012和下连接段1013，内管102设置在中支撑段1012内。两个封口件4分别设置在上盖体2和下盖体3的管口处，以在上盖体2和下盖体3内形成密闭的容置腔室。两个可移除的环状部件5分别设置在上连接段1011顶部和下连接段1013底部。
进一步如附图2-1及附图2-2所示，外管101的上连接段1011和下连接段1013的内壁上均设置有内螺纹103，上盖体2的下端与下盖体3的上端的外壁上均设置有与内螺纹103相配合的外螺纹201，以上盖体2举例来说，其上外螺纹201的结构可参见附图3-1及附图3-2。上盖体2与上连接段1011以及下盖体3与下连接段1013之间均螺纹连接，当移除可移除的环状部件5后，上盖体2和下盖体3均能够进一步螺旋运动，内管102的管口对两个封口件4施加压力以使封口件4破裂。
本发明实施例提供的试剂管，在用于盛装双组份生物试剂时，可将该双组份分别密封放置于上盖体2和下盖体3内，并和管体1部分螺纹连接，以形成
一个单独的试剂管。而在使用生物试剂时，通过移除可移除的环状部件5，进一步旋转上盖体2和下盖体3使其向着内管102管口的方向运动，直至内管102的管口对两个封口件4施加压力以使封口件4破裂，此时上盖体2和下盖体3内的组分将充分混合，实现即配即用。可见，本发明实施例提供的试剂管可同时承载诸如冻干粉和溶媒之类的两种组分，且使用时无需打开即可混合，如此不仅降低了人力物力成本，提高了操作便利性，且保证了其密封性，避免了试剂在混合时接触外源环境而造成二次污染，更加安全可靠。
此外，本领域技术人员可以理解的是，对于包括双组分，例如冻干粉组分和溶媒组分，且要求即配即用时生物试剂来说，一般要求相同批次的冻干粉和溶媒混合使用，以保证两者的变异系数一致并维持在较低水平，进而达到期望的试剂品质，但是，如若采用单独的两个试剂管盛装，受外界因素的影响，很容易导致不同批次的冻干粉和溶媒混合使用，从而影响试剂的品质。而利用本发明实施例提供的试剂管不仅则能够有效解决上述问题，保证试剂的品质，且避免在分装过程中对同一批次的组分进行标记，实现工厂内部的高精度及高效分装。当然，本发明实施例提供的试剂管不仅仅可用于生物试剂的存储及混合，在改变其尺寸时，其还可用于盛装即配即用的饮料、保健品等其他产品。
需要说明的是，第一方面，本发明实施例通过将两个可移除的环状部件5分别设置在上连接段1011顶部和下连接段1013底部，其作用是当该环状部件5存在时，上盖体2与上连接段1011以及下盖体3与下连接段1013之间只能是部分螺纹配合，即无法达到完全的契合；而当该环状部件5被移除后，上盖体2和下盖体3可进一步旋转，以向着内管102管口的方向运动，直至上盖体2与上连接段1011以及下盖体3与下连接段1013之间完全螺纹配合，并且此时内管102上下端的管口能够对上盖体2和下盖体3上的封口件4施加压力使其破裂(这也决定了环状部件5的宽度大小)。第二方面，本发明实施例使用上盖体2和下盖体3作为试剂的盛装容器，根据所盛装试剂的多少，来调整上盖体2和下盖体3的内部容积，并且上盖体2和下盖体3的内部容积可以相同或者不相同，本发明实施例在此并不对其作具体的限定。第三方面，本发明实施例通过将封口件4封堵住上盖体2和下盖体3的开口处，以使它们形成具有密封容置腔室的盛装容器。封口件4的结构优选与上盖体2和下盖体3的开口相一致，且在上盖体2和下盖体3内装入试剂后，通过热压融合、胶粘等方式将封口件4固定在它们的开口。
作为优选，如附图3-1及附图3-2所示，本发明实施例提供的试剂管还包括两个阻挡件6，两个阻挡件6分别设置在上盖体2和下盖体3的外壁上，用于与可移除的环状部件5相抵接触。通过在上盖体2和下盖体3的外壁上，例如在其中部位置处设置阻挡件6，可在无需两个盖体内组分混合的情况下，使阻挡件6与可移除的环状部件5相抵接触，避免过度旋转上盖体2和下盖体3而导致内管102的管口刺破封口件4。
具体地，作为优选，该阻挡件6为沿上盖体2和下盖体3的径向向外凸出的环状凸缘，如此可使其与可移除的环状部件5整体相抵接触，保证其阻挡效果。当然，该阻挡件6也可以为沿上盖体2和下盖体3的径向向外凸出的多个凸块。
具体地，在本发明实施例提供的试剂管中，如附图1-2所示，内管102包括顺次连通的上穿刺段1021、中连接段1022和下穿刺段1023，其中，内管102的中连接段1022与外管101的中支撑段1012通过连接件7固定在一起，该连接件7可以为两端分别固定在内管102的中连接段1022和外管101的中支撑段1012上的多个连接杆，或者并优选为位于两者之间的环片。并且，在内管102的上穿刺段1021与外管101的上连接段1011以及内管102的下穿刺段1023与外管101的下连接段1013之间设置有间隙，该间隙用于容纳上盖体2和下盖体3的管口的壁，以使上盖体2和下盖体3进一步旋转时它们的管口进入该间隙中，确保封口件4能够被内管102的管口冲破。
作为优选，在本发明实施例中，附图2-2所示，管体1为由外管101和内管102构成的上下通透的双圆柱体结构，作为优选，外管101和内管102同心设置，并且一体成型制备，如此可保证管体1的安全密封性。而上盖体2、下盖体3和可移除的环状部件5可配合管体1的结构使用单独的模具生产。并且，上盖体2和下盖体3优选内径一致，以便于试剂管的制造。
具体地，对于内管102来说，其中的上穿刺段1021和下穿刺段1023均为外径不变而内径可变的管体1，且上穿刺段1021的内径由下自上逐渐增大，下穿刺段1023的内径由上至下逐渐增大。通过控制上穿刺段1021和下穿刺段1023的外径不变，可便于上盖体2和下盖体3进一步旋转时，其内壁与内管102的外壁紧密配合。而控制上穿刺段1021和下穿刺段1023的内径可变，以使得上穿刺段1021的上端与下穿刺段1023的下端处的壁厚最小，更利于刺穿封口件4。根据所采用封口件4的材质来控制内管102中上穿刺段1021上端与
下穿刺段1023下端处的壁厚大小，只要满足在特定压力下封口件4可被其刺破即可。
可以理解的是，为了在上盖体2和下盖体3旋转时，保证内管102的管口能够伸入它们内部，上穿刺段1021和下穿刺段1023的外径应该小于等于上盖体2和下盖体3的内径。为了防止待混合的冻干粉与溶媒进入到内管102与外管101之间的缝隙中造成浪费，优选上穿刺段1021的外径等于上盖体2的内径，下穿刺段1023的外径等于下盖体3的内径，即使得上穿刺段1021和下穿刺段1023能够分别恰好进入上盖体2和下盖体3内，并且彼此之间不存在缝隙。
进一步地，为了提高内管102与上盖体2和下盖体3配合时的密封性，可以在上穿刺段1021和下穿刺段1023的外壁上设置有一层薄的，例如厚度为0.5-1mm左右的弹性涂层，或者在上穿刺段1021和下穿刺段1023的靠近中连接段1022的端部外壁上套装密封圈，从而在内管102进入上盖体2和下盖体3中时彼此能够更加紧密地配合，保证全部的冻干粉和溶媒完全混合在一起，进而保证生物试剂的品质。
作为优选，本发明实施例在外管101的外壁上设置有防滑结构8，以提高外管101与操作人员手部之间的摩擦力，使上盖体2和下盖体3的旋转更加省力。举例来说，该防滑结构8可以通过对外管101的外壁进行处理，以在其上形成防滑纹路，例如螺纹结构、交错的线性结构或其他几何形状来实现。或者，还可以在外管101的外壁上涂覆一层高弹涂层，并对该高弹涂层进行防滑纹路的处理或者在高弹涂层表面上设置多个颗粒状凸起来实现。
具体地，在本发明实施例中，可移除的环状部件5为本领域所常见的，例如其可以为可撕除的拉环，且该拉环可通过多个连接柱固定在外管101的上连接段1011的上缘和下连接段1013的下缘，拉环还具有开口，并且在开口的一侧设置拉环扣。或者本发明实施例中可移除的环状部件5为一侧带有开口的卡环。
由于所面对的对象为生物试剂，所以本发明实施例提供的试剂管应当是经过严格消毒的，且试剂管的制备过程应当在无菌条件下进行，以保证试剂管内部为无菌环境。具体地，管体1、上盖体2、下盖体3、可移除的环状部件5的材质均为医疗级聚合物，例如为医疗级聚丙烯、聚乙烯、亚克力共聚物、环烯烃共聚物、透明聚酰胺等，该类材质性能稳定，不易受外界环境影响而发生
变质，保证了其内盛装的试剂不会发生变质。而封口件4的材质选自医疗级金属箔，例如铝箔等，该类材质性能稳定且在一定压力下容易被刺破。
基于上述，本领域技术人员可采用如下方式使用该试剂管：
当用于盛装试剂，例如冻干粉和溶媒时，首先对该试剂管进行严格消毒处理，以使其达到医疗级。然后在无菌条件下将溶媒和冻干粉任选地放入上盖体2和下盖体3内，随后利用封口件4，例如封口铝箔封堵上盖体2和下盖体3。最后，将上盖体2和下盖体3与外管101螺纹配合连接，直至其上的阻挡件6与可移除的环状部件5相抵接触。此时，即可进行试剂的存储。
当使用该试剂时，将可移除的环状部件5移除，然后继续旋转上盖体2和下盖体3直至它们与外管101完全螺纹配合使内管102的管口刺破上盖体2和下盖体3上的封口件4，此时，冻干粉和溶媒可混合在一起，充分震荡试剂管即可使它们混合充分。使用时，任选地打开上盖体2或者下盖体3取出混合后的试剂即可。
可见，本发明实施例提供的试剂管，通过上述的二合一设计，实现了使用一支试剂管同时承载冻干粉和溶媒。而在使用时，不需要打开试剂管，无需接触外源环境即可实现充分混合，避免了试剂的二次污染。该试剂管降低了生产、运输及消毒等各项人力、物力成本，且操作便利，密封性好，安全性高，便于规模化推广应用。
以上所述仅为本发明的较佳实施例，并不用以限制本发明，凡在本发明的精神和原则之内，所作的任何修改、等同替换、改进等，均应包含在本发明的保护范围之内。
Claims (10)
- 一种试剂管，其特征在于，所述试剂管包括：两端开口的管体、上盖体、下盖体、封口件以及可移除的环状部件；所述管体包括外管和内管，所述外管包括顺次连通的上连接段、中支撑段和下连接段，所述内管设置在所述中支撑段内；两个所述封口件分别设置在所述上盖体和所述下盖体的盖口处，以在所述上盖体和所述下盖体内形成密闭的容置腔室；两个所述可移除的环状部件分别设置在所述上连接段顶部和所述下连接段底部；所述上连接段和所述下连接段的内壁上均设置有内螺纹，所述上盖体的下端与所述下盖体的上端的外壁上均设置有与所述内螺纹相配合的外螺纹，所述上盖体与所述上连接段以及所述下盖体与所述下连接段之间均螺纹连接，当移除所述可移除的环状部件后，所述上盖体和所述下盖体均能够进一步螺旋运动，所述内管的管口对两个所述封口件施加压力以使所述封口件破裂。
- 根据权利要求1所述的试剂管，其特征在于，所述试剂管还包括：阻挡件，两个所述阻挡件分别设置在所述上盖体和所述下盖体的外壁上，用于与所述可移除的环状部件相抵接触。
- 根据权利要求2所述的试剂管，其特征在于，所述阻挡件为沿所述上盖体和所述下盖体的径向向外凸出的环状凸缘。
- 根据权利要求1所述的试剂管，其特征在于，所述内管包括顺次连通的上穿刺段、中连接段和下穿刺段，所述中连接段与所述中支撑段通过连接件固定在一起，所述上穿刺段与所述上连接段以及所述下穿刺段与所述下连接段之间设置有间隙，所述间隙用于容纳所述上盖体和所述下盖体的盖口的壁。
- 根据权利要求4所述的试剂管，其特征在于，所述外管和所述内管同心设置，所述上穿刺段和所述下穿刺段均为外径不变而内径可变的管体，且所述上穿刺段的内径由下自上逐渐增大，所述下穿刺段的内径由上至下逐渐增大。
- 根据权利要求5所述的试剂管，其特征在于，所述上穿刺段的外径等于所述上盖体的内径，所述下穿刺段的外径等于所述下盖体的内径。
- 根据权利要求4所述的试剂管，其特征在于，所述上穿刺段和下穿刺段的外壁上设置有一层弹性涂层。
- 根据权利要求4所述的试剂管，其特征在于，所述上穿刺段和下穿刺段靠近所述中连接段的端部外壁上套装有密封圈。
- 根据权利要求1所述的试剂管，其特征在于，所述外管的外壁上设置有防滑结构。
- 根据权利要求1-9任一项所述的试剂管，其特征在于，所述管体、所述上盖体、所述下盖体的材质均为医疗级聚合物；所述封口件的材质选自医疗级金属箔。
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| CN110074092A (zh) * | 2019-03-28 | 2019-08-02 | 淮南市知产创新技术研究有限公司 | 一种环形扣盖抽真空样本存储密封装置及方法 |
| CN110074092B (zh) * | 2019-03-28 | 2021-07-13 | 淮南冠东信息科技有限公司 | 一种环形扣盖抽真空样本存储密封装置及方法 |
| CN110482175A (zh) * | 2019-09-23 | 2019-11-22 | 中交第二航务工程局有限公司 | 土压盾构皮带机冲渣防打滑装置 |
| CN110482175B (zh) * | 2019-09-23 | 2021-05-28 | 中交第二航务工程局有限公司 | 土压盾构皮带机冲渣防打滑装置 |
| CN117284622A (zh) * | 2023-11-24 | 2023-12-26 | 烟台至公生物医药科技有限公司 | 一种抗肿瘤临床质谱检验试剂盒 |
| CN117284622B (zh) * | 2023-11-24 | 2024-01-26 | 烟台至公生物医药科技有限公司 | 一种抗肿瘤临床质谱检验试剂盒 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN109328111B (zh) | 2021-07-09 |
| CN109328111A (zh) | 2019-02-12 |
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