WO2017214865A1 - Kit de réactifs ayant une fonction de minuterie, une fonction de rappel de chargement et une fonction de gestion sans fil - Google Patents

Kit de réactifs ayant une fonction de minuterie, une fonction de rappel de chargement et une fonction de gestion sans fil Download PDF

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Publication number
WO2017214865A1
WO2017214865A1 PCT/CN2016/085767 CN2016085767W WO2017214865A1 WO 2017214865 A1 WO2017214865 A1 WO 2017214865A1 CN 2016085767 W CN2016085767 W CN 2016085767W WO 2017214865 A1 WO2017214865 A1 WO 2017214865A1
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WO
WIPO (PCT)
Prior art keywords
reagent
timing
function
test kit
timer
Prior art date
Application number
PCT/CN2016/085767
Other languages
English (en)
Chinese (zh)
Inventor
彭鹏
Original Assignee
彭鹏
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 彭鹏 filed Critical 彭鹏
Priority to PCT/CN2016/085767 priority Critical patent/WO2017214865A1/fr
Publication of WO2017214865A1 publication Critical patent/WO2017214865A1/fr

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16Z—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS, NOT OTHERWISE PROVIDED FOR
    • G16Z99/00—Subject matter not provided for in other main groups of this subclass

Definitions

  • the present invention relates to the field of biotechnology, and more particularly to a kit having a metering, sample reminder, and wireless management function.
  • kits In the field of biotechnology, in addition to technical breakthroughs, it is more important to improve the efficiency of research and experimentation. Among them, the emergence of kits plays an important role.
  • the kit standardizes the steps of common biological experiments, providing the experimenter with the reagents to be prepared and the optimized loading method, which greatly increases the speed of the experiment and the standardization of the results.
  • the complexity of the experiment is increasing, the number of reagents in the existing kits is also increasing, and the step of adding samples is becoming more and more complicated.
  • the general kit contains Taq enzyme, buffer, chromogenic dye and sterile ultrapure water.
  • the reagents required by the experimenter include at least the upstream primer. Downstream primers and template, a total of 7 reagents together to prepare a fluorescent quantitative PCR reaction system.
  • the experimenter will have the phenomenon of missing, adding, adding, etc. during the process of adding samples. The reason is that there are many kinds of reagents, and the loading process cannot be well identified and marked. When other urgent matters cause the ongoing experiment to be interrupted, an error is inevitable.
  • kits are also constantly increasing.
  • management of the kits produced has always been a very challenging task.
  • most manufacturers use the management method to record the relevant information of the kit in the paper document, and find the relevant documents to check if necessary.
  • This manual recording and comparison management mode results in inefficient and high error rates for kit management, and the additional expenditure for "correction" generated each year amounts to millions or even tens of millions.
  • the present invention provides a kit having a timing, a sample reminder, and a wireless management function.
  • the technical solution adopted by the present invention is: a kit with a metering, sample reminding and wireless management function, including a kit body, a lid, a liner, a timing device for implanting a kit, and a close range Wireless communication N FC tag.
  • the counting device is composed of a control unit, a display module, a regulating button and a small battery.
  • the display module and the regulating button are respectively electrically connected to the control unit, and the adjusting button adjusts the counting unit of the control unit according to the demand, and passes through the display module. Display relevant information. In the non-counting state, the display module can display the current time.
  • the NFC tag of the short-range wireless communication is composed of a data storage module and a data transmission module. The output end of the data storage module is electrically connected to the data transmission module, and the data transmission module wirelessly transmits the signal to the intelligent management terminal used by the staff through the NFC chip.
  • the liner of the kit body is provided with a pipette tip head collecting hole and a reagent rotating disk, and an arrow indicator light is further disposed between the two.
  • the lining plate is spaced apart from the opening of the box body such that the lining plate forms an open receiving space with the box body; the reagent rotating disk is provided with a plurality of reagent holes, and A power mechanism is connected.
  • the reagent box body is further provided with an inductor, the sensor is disposed corresponding to a bottom of the pipette tip head collecting hole, and the sensor receives the hole by sensing the pipette tip head The bottom controls the rotation of the reagent rotating disk and the color of the arrow indicator light.
  • control unit is a single chip microcomputer.
  • the display module is a liquid crystal digital display with a backlight.
  • the small battery is a lithium ion battery.
  • the number of the control buttons is four, wherein three control the adjustment of hours, minutes, and seconds, and the other one controls the start/pause/end timing.
  • the inductor is connected to the bottom of the pipette tip collecting hole by a spring.
  • the reagent rotating disc is provided with 8 reagent holes; the power mechanism connected thereto is a stepping motor, and is connected to the inductor and controlled by the inductor.
  • the arrow indicator is made of LED, connected to the sensor, and controlled by the sensor.
  • the smart terminal used by the staff is set on the mobile phone and displays related information of the kit through the mobile phone interface.
  • the invention implants a timing module in the kit, which facilitates the experimenter to carry out the calibration step in the experiment process, enhances the continuity of the experiment, reduces the troubles that may be encountered in the experiment process, and finally improves the quality of the experimental result;
  • the timer display can be used to display the current time to prevent the experimenter from missing other important matters.
  • the reagent hole can be rotated by the reagent disk, which can help the experimenter to add the sample reminder to avoid the mistake of adding the wrong sample.
  • FIG. 2 is a schematic view showing the structure of a reagent rotating disk, an arrow indicator lamp, and a pipette dp head collecting hole as shown in FIG. 1.
  • FIG. 3 is a schematic structural diagram of the short-range wireless communication NFC tag.
  • a kit having a timing, a sample reminder, and a wireless management function includes a kit body 10 and a lid 20, and the kit body is provided with a liner 30 and a timing device 40. And NFC tag 80 for short-range wireless communication.
  • the timing device is composed of a control unit, a display module, a control button and a small battery.
  • the display module and the control button are respectively electrically connected to the control unit, and the control button adjusts the timing of the control unit according to the demand, and the related information is displayed through the display module. display. In the non-timed state, the display module can display the current time.
  • the lining plate 30 is provided with a pipette tip collecting hole 32 and a reagent rotating disk 36, and an arrow indicator 34 is further disposed between the two, and the reagent rotating disk 36 is disposed on the reagent rotating plate 36.
  • the sensor 60 is disposed in the casing 10, and the inductor 60 is disposed corresponding to the bottom of the pipette tip collecting hole 32, and the inductor 60 controls the stepping motor 70 through the bottom of the inductive pipette tip collecting hole 32.
  • the rotation of the reagent rotating disk 36 and the color of the arrow indicator light 34 are illuminated.
  • the inductor 60 is connected to the bottom of the pipette tip head collecting hole 32 by a spring 50.
  • the discarded tip is driven into the inductive pipette tip head collecting hole 32, and the sensor 60 passes through the inductive pipette tip to collect the bottom of the hole 32, and controls the breaking motor 70 to drive the reagent rotation.
  • the color of the disk 36 is rotated and the arrow indicator light 34 is illuminated.
  • the color of the arrow indicator light 34 is in one-to-one correspondence with the reagent holes on the reagent rotating disk 36.
  • the eight colors of red, orange, yellow, green, cyan, blue, purple, and white correspond to 1-8 on the reagent rotating disk 36, respectively. Hole.
  • control stepper motor 70 drives the reagent rotating disk 36 to rotate 45° to its next reagent hole, and controls the arrow indicator. 34 lights up the color of the corresponding reagent hole.
  • the short-range wireless communication NFC tag mainly includes a data storage module 801, a data transmission module 802, and an NFC chip 803.
  • the output of the data storage module is electrically connected to the data transmission module, and the data transmission module wirelessly transmits the signal to the intelligent management terminal (usually the mobile phone 90) used by the user through the NFC chip.
  • the kit with the function of counting and the reminding function of the sample is composed of a control unit, a metering device and a battery, and a sensor, a pipette tip collecting hole, and a reagent rotating disk.
  • the power mechanism can facilitate the experimenter to carry out the timing steps in the experiment process, improve the continuity of the experiment, reduce the troubles that may be encountered during the experiment, and finally improve the quality of the experimental results; in the non-timed state, the meter display It can be used to display the current time, to prevent the experimenter from missing other important matters; the peer can also function to instruct the experimenter to add reminders.
  • the present invention is not limited to the above-described preferred embodiments, and any other form of product can be derived by anyone of the present invention, but without any change in its shape or structure, The same or similar technical solutions are all within the scope of the present invention.
  • the invention implants a timing module in the kit, which facilitates the experimenter to carry out the calibration step in the experiment process, enhances the continuity of the experiment, reduces the troubles that may be encountered in the experiment process, and finally improves the quality of the experimental result;
  • the meter display can be used to display the current time to prevent the experimenter from missing other important matters.
  • the reagent hole can be rotated by the reagent disk, which can help the experimenter to add the sample reminder.
  • the experiment caused by the failure of the sample at the same time, the intelligent management terminal and the kit can realize the non-contact point-to-point data transmission within a distance of five centimeters, solving many problems of the traditional kit production management method, and improving the management efficiency and accuracy. , reducing management costs for production companies.

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)

Abstract

L'invention porte sur un kit de réactifs ayant une fonction de minuterie, une fonction de rappel de chargement et une fonction de gestion sans fil. En fournissant un système de minuterie composé d'une unité de commande, d'un dispositif de minuterie (40) et d'une batterie de stockage, et en fournissant un capteur (6), un collecteur de pointe de pipette (32), une plaque tournante de réactifs (36), et un mécanisme de puissance, la présente invention facilite la synchronisation pendant une expérience pour le personnel de laboratoire, ce qui permet d'améliorer la fluidité d'une expérience, de réduire les problèmes potentiels pendant l'expérience et finalement d'améliorer la qualité du résultat de l'expérience. Lorsque la fonction de minuterie n'est pas activée, un écran d'affichage de minuterie peut afficher le temps courant pour empêcher le personnel de laboratoire de manquer des tâches importantes, et fournir un indicateur pour rappeler au personnel de laboratoire de charger un réactif. En outre, en employant une transmission de données de bout en bout sans contact entre un terminal de gestion intelligent et le kit de réactifs dans une plage de cinq centimètres, la présente invention résout de nombreux problèmes de procédés de gestion de fabrication de kits de réactifs classiques, améliorant ainsi l'efficacité et la précision de gestion, et réduisant le coût de gestion du fabricant.
PCT/CN2016/085767 2016-06-15 2016-06-15 Kit de réactifs ayant une fonction de minuterie, une fonction de rappel de chargement et une fonction de gestion sans fil WO2017214865A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/CN2016/085767 WO2017214865A1 (fr) 2016-06-15 2016-06-15 Kit de réactifs ayant une fonction de minuterie, une fonction de rappel de chargement et une fonction de gestion sans fil

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2016/085767 WO2017214865A1 (fr) 2016-06-15 2016-06-15 Kit de réactifs ayant une fonction de minuterie, une fonction de rappel de chargement et une fonction de gestion sans fil

Publications (1)

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WO2017214865A1 true WO2017214865A1 (fr) 2017-12-21

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PCT/CN2016/085767 WO2017214865A1 (fr) 2016-06-15 2016-06-15 Kit de réactifs ayant une fonction de minuterie, une fonction de rappel de chargement et une fonction de gestion sans fil

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060190185A1 (en) * 1997-08-11 2006-08-24 Ventana Medical Systems, Inc. Memory management method and apparatus for automated biological reaction system
US20130025298A1 (en) * 2011-07-28 2013-01-31 Biocision, Inc. Preventing sample degradation from transient temperature fluctuations
CN203259385U (zh) * 2013-03-12 2013-10-30 深圳华大基因研究院 生物样品分配防错设备及系统
CN204779612U (zh) * 2015-06-09 2015-11-18 盐城卫生职业技术学院 一种细胞培养板
CN205210093U (zh) * 2015-11-09 2016-05-04 重庆创生生物科技集团有限公司 一种用于免疫缺陷病毒检测试剂盒

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060190185A1 (en) * 1997-08-11 2006-08-24 Ventana Medical Systems, Inc. Memory management method and apparatus for automated biological reaction system
US20130025298A1 (en) * 2011-07-28 2013-01-31 Biocision, Inc. Preventing sample degradation from transient temperature fluctuations
CN203259385U (zh) * 2013-03-12 2013-10-30 深圳华大基因研究院 生物样品分配防错设备及系统
CN204779612U (zh) * 2015-06-09 2015-11-18 盐城卫生职业技术学院 一种细胞培养板
CN205210093U (zh) * 2015-11-09 2016-05-04 重庆创生生物科技集团有限公司 一种用于免疫缺陷病毒检测试剂盒

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