Classifications

• • G—PHYSICS
  • G01—MEASURING; TESTING
  • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
  • G01R33/00—Arrangements or instruments for measuring magnetic variables
  • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
  • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
  • G01R33/48—NMR imaging systems
  • G01R33/4828—Resolving the MR signals of different chemical species, e.g. water-fat imaging
• • G—PHYSICS
  • G01—MEASURING; TESTING
  • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
  • G01R33/00—Arrangements or instruments for measuring magnetic variables
  • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
  • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
  • G01R33/48—NMR imaging systems
• • G—PHYSICS
  • G01—MEASURING; TESTING
  • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
  • G01R33/00—Arrangements or instruments for measuring magnetic variables
  • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
  • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
  • G01R33/48—NMR imaging systems
  • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
  • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
  • G01R33/561—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution by reduction of the scanning time, i.e. fast acquiring systems, e.g. using echo-planar pulse sequences
  • G01R33/5615—Echo train techniques involving acquiring plural, differently encoded, echo signals after one RF excitation, e.g. using gradient refocusing in echo planar imaging [EPI], RF refocusing in rapid acquisition with relaxation enhancement [RARE] or using both RF and gradient refocusing in gradient and spin echo imaging [GRASE]
  • G01R33/5617—Echo train techniques involving acquiring plural, differently encoded, echo signals after one RF excitation, e.g. using gradient refocusing in echo planar imaging [EPI], RF refocusing in rapid acquisition with relaxation enhancement [RARE] or using both RF and gradient refocusing in gradient and spin echo imaging [GRASE] using RF refocusing, e.g. RARE
• • G—PHYSICS
  • G01—MEASURING; TESTING
  • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
  • G01R33/00—Arrangements or instruments for measuring magnetic variables
  • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
  • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
  • G01R33/48—NMR imaging systems
  • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
  • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
  • G01R33/561—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution by reduction of the scanning time, i.e. fast acquiring systems, e.g. using echo-planar pulse sequences
  • G01R33/5615—Echo train techniques involving acquiring plural, differently encoded, echo signals after one RF excitation, e.g. using gradient refocusing in echo planar imaging [EPI], RF refocusing in rapid acquisition with relaxation enhancement [RARE] or using both RF and gradient refocusing in gradient and spin echo imaging [GRASE]
  • G01R33/5618—Echo train techniques involving acquiring plural, differently encoded, echo signals after one RF excitation, e.g. using gradient refocusing in echo planar imaging [EPI], RF refocusing in rapid acquisition with relaxation enhancement [RARE] or using both RF and gradient refocusing in gradient and spin echo imaging [GRASE] using both RF and gradient refocusing, e.g. GRASE
• • G—PHYSICS
  • G01—MEASURING; TESTING
  • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
  • G01R33/00—Arrangements or instruments for measuring magnetic variables
  • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
  • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
  • G01R33/48—NMR imaging systems
  • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
  • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
  • G01R33/565—Correction of image distortions, e.g. due to magnetic field inhomogeneities
  • G01R33/56554—Correction of image distortions, e.g. due to magnetic field inhomogeneities caused by acquiring plural, differently encoded echo signals after one RF excitation, e.g. correction for readout gradients of alternating polarity in EPI
• • G—PHYSICS
  • G01—MEASURING; TESTING
  • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
  • G01R33/00—Arrangements or instruments for measuring magnetic variables
  • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
  • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
  • G01R33/48—NMR imaging systems
  • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
  • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
  • G01R33/565—Correction of image distortions, e.g. due to magnetic field inhomogeneities
  • G01R33/56563—Correction of image distortions, e.g. due to magnetic field inhomogeneities caused by a distortion of the main magnetic field B0, e.g. temporal variation of the magnitude or spatial inhomogeneity of B0

Definitions

• the invention relates to the field of magnetic resonance (MR) imaging. It concerns a method of MR imaging of a portion of a body placed in the examination volume of a MR device.
• the invention also relates to a MR device and to a computer program to be run on a MR device.
• Image-forming MR methods which utilize the interaction between magnetic fields and nuclear spins in order to form two-dimensional or three-dimensional images are widely used nowadays, notably in the field of medical diagnostics, because for the imaging of soft tissue they are superior to other imaging methods in many respects, do not require ionizing radiation and are usually not invasive.
• the body of the patient to be examined is arranged in a strong, uniform magnetic field Bo whose direction at the same time defines an axis (normally the z-axis) of the co-ordinate system on which the measurement is based.
• the magnetic field Bo produces different energy levels for the individual nuclear spins in dependence on the magnetic field strength which can be excited (spin resonance) by application of an electromagnetic alternating field (RF field) of defined frequency (so-called Larmor frequency, or MR frequency).
• the distribution of the individual nuclear spins produces an overall magnetization which can be deflected out of the state of equilibrium by application of an electromagnetic pulse of appropriate frequency (RF pulse) perpendicular to the z-axis, so that the magnetization performs a precessional motion about the z-axis.
• the precessional motion describes a surface of a cone whose angle of aperture is referred to as flip angle.
• the magnitude of the flip angle is dependent on the strength and the duration of the applied electromagnetic pulse.
• 90° pulse the spins are deflected from the z-axis to the transverse plane (flip angle 90°).
• the magnetization relaxes back to the original state of equilibrium, in which the magnetization in the z direction is built up again with a first time constant Ti (spin-lattice or longitudinal relaxation time), and the magnetization in the direction perpendicular to the z direction relaxes with a second time constant T 2 (spin-spin or transverse relaxation time).
• Ti spin-lattice or longitudinal relaxation time
• T 2 spin-spin or transverse relaxation time
• the decay of the transverse magnetization is accompanied, after application of, for example, a 90° pulse, by a transition of the nuclear spins (induced by local magnetic field inhomogeneities) from an ordered state with the same phase to a state in which all phase angles are uniformly distributed (dephasing).
• the dephasing can be compensated by means of a refocusing pulse (for example a 180° pulse). This produces an echo signal in the receiving coils.
• the signal picked up in the receiving coils then contains components of different frequencies which can be associated with different locations in the body.
• the signal data obtained via the receiving coils correspond to the spatial frequency domain and are called k-space data.
• the k-space data usually include multiple lines acquired with different phase encoding. Each k-space line is digitized by collecting a number of samples. A set of k-space data is converted to an MR image, e.g., by means of Fourier transformation.
• FIG. 2 a schematic pulse sequence diagram of a conventional turbo spin echo (TSE) Dixon sequence is depicted.
• TSE turbo spin echo
• M frequency-encoding direction
• P phase-encoding direction
• S slice-selection direction
• the diagram shows RF excitation and refocusing pulses as well as the time intervals during which echo signals are acquired, designated by ACQ.
• the diagram covers the acquisition of the first three echo signals of one shot of the imaging sequence.
• the double arrows indicate the shifting of the readout magnetic field gradients (top) and the acquisition windows ACQ (bottom) between multiple repetitions of one shot with identical phase encoding. According to the shifting of the readout magnetic field gradients, different phase offsets of the signal contributions from water protons and fat protons, respectively, are obtained on which the Dixon-type water/fat separation is based.
• a drawback of the conventional approach is that, in comparison to standard (non-Dixon) TSE sequences, a higher receive bandwidth is required for a given echo spacing in Dixon TSE sequences. This results in a significantly reduced SNR. This may be avoided by employing a larger echo spacing. However, longer or more echo trains are required in this case. This results in less coverage and more blurring in the reconstructed MR images, or in longer scan times. Furthermore, FID artifacts may be a problem with the conventional approach. A cancellation of FID artifacts by averaging of two acquisitions with opposite phases of the refocusing RF pulses is usually impracticable since it would require doubling (once more) the number of acquisitions and thus increase scan times even further.
• US patent application US2016/0033605 concerns a multi-spin-echo acquisitions in which bipolar gradient pulses are employed to form echo-pairs between refocusing RF pulses.
• a method of MR imaging of an object placed in an examination volume of a MR device comprises the following steps:
• a second imaging sequence which comprises a series of refocusing RF pulses, wherein a pair of echo signals is generated in each time interval between two consecutive refocusing RF pulses
• two separate TSE sequences are used to acquire the single echo signals and the pairs of echo signals respectively.
• the timing of the bipolar readout gradients in the second imaging sequence is chosen to shift the acquisition windows of the echo signals such that appropriate phase offsets of the signal contributions from water protons and fat protons are provided on which the Dixon-type separation of these signal contributions is based in the reconstruction step.
• the bipolar readout magnetic field gradients applied in the second imaging sequence are preferably stronger than the unipolar readout magnetic field gradients of the first imaging sequence, wherein each pair of echo signals is acquired using a corresponding pair of temporally adjoining readout magnetic field gradients having opposed polarities. It can thus be achieved that the duration of each dual-echo readout is essentially the same as that of the single-echo readout of the first acquisition.
• the echo signals generated by the first imaging sequence are acquired using the unipolar readout magnetic field gradients having a first gradient strength
• the pairs of echo signals generated by the second imaging sequence are acquired using the bipolar readout magnetic field gradient having a second gradient strength which is larger than the first gradient strength
• the first echo signals are acquired using a signal receiving bandwidth which is smaller than the signal receiving bandwidth used for the acquisition of the second echo signals.
• the whole acquisition is thus split up into two, usually interleaved sub-acquisitions, performed with a low-bandwidth sub-sequence (the first imaging sequence) and a high-bandwidth sub-sequence (the second imaging sequence), respectively.
• a high signal sampling efficiency is achieved by sampling the first echo signals during most of the interspacing between the refocusing RF pulses.
• This low-bandwidth and high sampling efficiency yields a high SNR.
• the first imaging sequence with its single-echo readout is actually the same as a standard TSE sequence and thus provides the same sampling efficiency.
• the second imaging sequence achieves only a lower sampling efficiency and provides a lower SNR per echo, since it has to cover the same gradient integral in about half the time. However, by sampling a pair of echo signals, it achieves a similar, high sampling efficiency and SNR as the first imaging sequence.
• the MR image reconstructed from the echo signals acquired according to the invention benefits from the higher sampling efficiency and higher SNR of both imaging sequences.
• each acquired pair of echo signals generated by the second imaging sequence is combined into a virtual echo signal, wherein signal contributions from water protons and fat protons are separated by a two-point Dixon technique using the echo signals generated by the first imaging sequence and the virtual echo signals.
• the SNR of a single-echo image reconstructed from the unipolar single-echo readout according to the invention is (ideally) by a square root of two higher than that in two single- echo images reconstructed from the bipolar dual-echo readout.
• the corresponding single-echo images can, after a suitable phase correction, be averaged to obtain a single-echo image with the same SNR as the single-echo image reconstructed from the unipolar single- echo readout. This still applies if only two partial echo signals are acquired in the bipolar dual-echo readout (to achieve favorable echo shifts at a particular field strength, e.g., or to accommodate constraints on the readout magnetic field gradient strength and slew rate imposed by the used MR apparatus). This then allows employing conventional two-point Dixon methods for the water/fat separation.
• signal contributions from water protons and fat protons may be separated directly by a three-point Dixon technique using the three corresponding echo signals generated by the first and second imaging sequences.
• the method of the invention comprises the following steps:
• an imaging sequence which comprises a series of refocusing RF pulses, wherein a pair of echo signals is generated in each time interval between two consecutive refocusing RF pulses,
• the single-point method has basically the same advantages as discussed above (high SNR, good sampling efficiency). However, it relates only to single- echo instead of dual-echo Dixon imaging.
• the virtual echo signals may be computed as phasor weighted averages of the echo signals of each pair of echo signals.
• the voxel values in the three single- echo MR images Si - S3 can be modeled by
• W and F being the magnitude of the water and fat signal
• c being the complex weighting factor describing the amplitude and phase variation of a pure fat signal relative to a pure water signal at the (positive) echo shift
• Po being the phasor representation of the (initial) phase at the spin echo
• P being the phasor representation of the effect of main field inhomogeneity
• i - P3 being the phasor representations of the effect of eddy currents. Relaxation effects are neglected for the sake of simplicity.
• P2 can be derived from S2, and 6*13 can be multiplied with P2 * .
• Flow compensation may be applied in accordance with the method of the invention by means of gradient moment nulling.
• the zeroth moment of the readout magnetic field gradient is usually zero both at the echo time of the single echo signal and at the time of the subsequent refocusing RF pulse, while the first moment is only zero at the latter.
• the phase encoding magnetic field gradient only the zeroth moment is zero at the respective subsequent refocusing pulse.
• the typically applied magnetic field gradients for spoiling for FID artifact reduction prevent any flow compensation.
• the readout magnetic field gradient differs from the first imaging sequence. Its zeroth moment is usually zero both at the echo times of the pair of echo signals and at the time of the subsequent refocusing RF pulse. Its first moment is non-zero at the echo time of the first of the pair of echo signals while it is zero at the echo time of the second of the pair of echo signals. In this way, differences between the two single-echo MR images reconstructed from the pair of echo signals can be exploited for an improved flow compensation.
• a higher signal amplitude at a given voxel position in the second single-echo MR image than in the first single-echo MR image can be attributed to flow-related intra- voxel dephasing and can be compensated by considering the signal amplitude in the second single-echo MR image only.
• a cancellation of FID artifacts can be achieved according to the invention for the bipolar dual-echo readout (second imaging sequence) by averaging of two acquisitions with opposite phases of the refocusing RF pulses without increasing the scan time.
• a phase-encoding magnetic field gradient ('blip gradient') is switched between the two echo signals of each pair of echo signals generated by the second imaging sequence.
• Each pair of echo signals is acquired twice, each time using the same phase encoding but opposed phases of the RF refocusing pulses.
• two different k-space lines are acquired in each time interval between two refocusing RF pulses. These two k-space lines are measured twice in two acquisitions with opposite phase of the refocusing pulses and then separately averaged for a cancellation of FID artifacts.
• the method of the invention described thus far can be carried out by means of a MR device including at least one main magnet coil for generating an essentially uniform, static magnetic field Bo within an examination volume, a number of gradient coils for generating switched magnetic field gradients in different spatial directions within the examination volume, at least one body RF coil for generating RF pulses within the examination volume and/or for receiving MR signals from a body of a patient positioned in the examination volume, a control unit for controlling the temporal succession of RF pulses and switched magnetic field gradients, and a reconstruction unit for reconstructing MR images from the received MR signals.
• the method of the invention can be implemented by a corresponding programming of the reconstruction unit and/or the control unit of the MR device.
• the method of the invention can be advantageously carried out on most MR devices in clinical use at present. To this end it is merely necessary to utilize a computer program by which the MR device is controlled such that it performs the above-explained method steps of the invention.
• the computer program may be present either on a data carrier or be present in a data network so as to be downloaded for installation in the control unit of the MR device.
• Figure 1 shows a MR device for carrying out the method of the invention
• Figure 2 shows a schematic (simplified) pulse sequence diagram of a conventional TSE Dixon imaging sequence
• Figure 3 shows schematic (simplified) pulse sequence diagrams of the first and second imaging sequences according to the invention
• Figure 4 schematically shows details of the bipolar readout magnetic field gradient applied in the second imaging sequence shown in Figure 3.
• a MR device 1 is shown as a block diagram.
• the device comprises superconducting or resistive main magnet coils 2 such that a substantially uniform, temporally constant main magnetic field Bo is created along a z-axis through an examination volume.
• the device further comprises a set of (1 st , 2 nd , and - where applicable - 3 rd order) shimming coils 2', wherein the current flow through the individual shimming coils of the set 2' is controllable for the purpose of minimizing Bo deviations within the examination volume.
• a magnetic resonance generation and manipulation system applies a series of RF pulses and switched magnetic field gradients to invert or excite nuclear magnetic spins, induce magnetic resonance, refocus magnetic resonance, manipulate magnetic resonance, spatially and otherwise encode the magnetic resonance, saturate spins, and the like to perform MR imaging.
• a gradient pulse amplifier 3 applies current pulses to selected ones of whole-body gradient coils 4, 5 and 6 along x, y and z-axes of the
• a digital RF frequency transmitter 7 transmits RF pulses or pulse packets, via a send/receive switch 8, to a body RF coil 9 to transmit RF pulses into the examination volume.
• a typical MR imaging sequence is composed of a packet of RF pulse segments of short duration which, together with any applied magnetic field gradients, achieve a selected manipulation of nuclear magnetic resonance.
• the RF pulses are used to saturate resonance, excite resonance, invert magnetization, refocus resonance, or manipulate resonance and select a portion of a body 10 positioned in the examination volume.
• the MR signals are also picked up by the body RF coil 9.
• a set of local array RF coils 1 1, 12, 13 are placed contiguous to the region selected for imaging.
• the array coils 1 1, 12, 13 can be used to receive MR signals induced by body-coil RF transmissions.
• the resultant MR signals are picked up by the body RF coil 9 and/or by the array RF coils 1 1, 12, 13 and demodulated by a receiver 14 preferably including a preamplifier (not shown).
• the receiver 14 is connected to the RF coils 9, 1 1, 12 and 13 via the send/receive switch 8.
• a host computer 15 controls the shimming coils 2' as well as the gradient pulse amplifier 3 and the transmitter 7 to generate the imaging sequences of the invention.
• the receiver 14 receives a single or a plurality of MR data lines in rapid succession following each RF excitation pulse.
• a data acquisition system 16 performs analog-to-digital conversion of the received signals and converts each MR data line to a digital format suitable for further processing. In modern MR devices the data acquisition system 16 is a separate computer which is specialized in acquisition of raw image data.
• the digital raw image data are reconstructed into an image representation by a reconstruction processor 17 which applies a Fourier transform or other appropriate reconstruction algorithms, such as SENSE.
• the MR image may represent a planar slice through the patient, an array of parallel planar slices, a three-dimensional volume, or the like.
• the image is then stored in an image memory where it may be accessed for converting slices, projections, or other portions of the image representation into appropriate format for visualization, for example via a video monitor 18 which provides a man-readable display of the resultant MR image.
• efficient TSE Dixon imaging is achieved by combining a unipolar single-echo readout at a low receive bandwidth with a bipolar dual- echo readout at a high bandwidth to maximize the SNR.
• FIG. 3 shows a pulse sequence diagram 31 of a TSE sequence constituting a first imaging sequence according to the invention.
• the diagram 31 shows switched magnetic field gradients in the frequency-encoding direction (M), the phase-encoding direction (P) and the slice-selection direction (S).
• the diagram shows the RF excitation and refocusing pulses as well as the time intervals during which echo signals are acquired, designated by ACQ.
• a single echo signal is acquired during each interval ACQ at a first (low) receive bandwidth to obtain a high SNR.
• comparatively weak unipolar readout magnetic field gradients in the M-direction
• a high sampling efficiency is reached in the first imaging sequence by sampling the MR signals during most of the interspacing between the refocusing pulses.
• FIG. 3 shows a further pulse sequence diagram 32 for the second imaging sequence according to the invention.
• the second imaging sequence is also a TSE sequence with echo shifting to obtain a pair of echo signals in each time interval between two consecutive refocusing RF pulses.
• the pairs of echo signals are acquired using bipolar readout magnetic field gradients.
• Each pair of echo signals is acquired using a corresponding pair of readout magnetic field gradients having opposed polarities.
• the corresponding signal acquisition periods are indicated by ACQ1 and ACQ2.
• the first echo signal of each pair of echo signals is acquired during interval ACQ1 while the second echo signal of each pair of echo signals is acquired during interval ACQ2.
• the spacing between the refocusing RF pulses is essentially identical in the first and second imaging sequences, while the readout magnetic field gradient strength as well as the receiving signal bandwidth are doubled in the second imaging sequence with respect to the first imaging sequence to enable echo shifting.
• the two separate TSE sequences according to diagrams 31 and 32 are applied in an interleaved fashion according to the invention.
• the first and second imaging sequences are used to acquire the single echo signals and the pairs of echo signals respectively.
• the timing of the bipolar readout gradients in the second imaging sequence (diagram 32) is chosen to shift the acquisition windows ACQ1, ACQ2 of the echo signals such that different phase offsets of the signal contributions from water protons and fat protons are provided on which the Dixon- type separation of these signal contributions is based in the final step of MR image reconstruction.
• three single-echo MR images can be reconstructed from the echo signals generated by the first and second imaging sequences according to the invention.
• a three-point Dixon method can then directly be applied to the three single-echo MR images for separating the contributions from fat and water protons.
• the water/fat separation can be modeled by
• the water and fat signal contributions can be estimated for each voxel by a least squares fitting approach (see Reeder et al., Magnetic Resonance in Medicine, 51, 35-45, 2004).
• the difference in SNR in the single- echo images is taken into account by using a correspondingly weighted linear least squares estimation instead, which provides a better SNR.
• the former can be reduced by shortening and strengthening the initial dephasing and the final rephasing lobes of the readout magnetic field gradients (while preserving their area).
• This is illustrated in the middle diagram of Figure 4.
• the left diagram shows the readout magnetic field gradient lobes from diagram 32 of Figure 3.
• the first moment can even be set to zero by strengthening the two middle lobes of the readout magnetic field gradient (possibly entailing the acquisition of partial echoes), as illustrated in the right diagram of Figure 4. However, the first moment of the readout magnetic field gradient is then no longer zero at the time of the second echo signal.
• a phase encoding magnetic field gradient ('blip') can be introduced between the two acquisition intervals ACQ1, ACQ2, such that two different k-space lines are acquired in each interval between two consecutive refocusing RF pulses.
• the application of the blip magnetic field gradient leads to one half of the k-space lines being acquired with a negative shift of the echo signals and the other half of the k-space lines being acquired with a positive shift of the echo signals.
• These two subsets of k-space lines can simply be matched by exploiting their conjugate complex symmetry.
• a possible phase in the MR image is known from the echo signals generated with the first imaging sequence and can be considered appropriately in this process.
• the information gained on the FID artifacts by the bipolar dual-echo readout can be used to also suppress FID artifacts in the unipolar single-echo readout, without increasing scan time.
• a first water/fat separation can be performed without such a suppression. If it indicates that a certain voxel essentially contains either water or fat, the FID contribution in this voxel known from the bipolar dual-echo readout can be modulated to reflect the phase evolution from the respective shift of the echo signals to the spin echo, using the information on the main magnetic field inhomogeneity provided by the first water/fat separation, and then subtracted from the corresponding signal in this voxel obtained from the unipolar single-echo readout.

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