WO2017206026A1 - 提升运动能力的能量组合物 - Google Patents

提升运动能力的能量组合物 Download PDF

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Publication number
WO2017206026A1
WO2017206026A1 PCT/CN2016/083942 CN2016083942W WO2017206026A1 WO 2017206026 A1 WO2017206026 A1 WO 2017206026A1 CN 2016083942 W CN2016083942 W CN 2016083942W WO 2017206026 A1 WO2017206026 A1 WO 2017206026A1
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Prior art keywords
parts
astaxanthin
limited
composition
salt
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PCT/CN2016/083942
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English (en)
French (fr)
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袁晓
吴连华
刘建国
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阿士力(深圳)运动健康科技有限公司
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Application filed by 阿士力(深圳)运动健康科技有限公司 filed Critical 阿士力(深圳)运动健康科技有限公司
Priority to PCT/CN2016/083942 priority Critical patent/WO2017206026A1/zh
Priority to CN201680086362.4A priority patent/CN109475513A/zh
Publication of WO2017206026A1 publication Critical patent/WO2017206026A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants

Definitions

  • the invention relates to the technical field of foods, medicines and health care medicines, in particular to foods which are resistant to fatigue and recovery after fatigue and their applications.
  • Astaxanthin also known as shrimp yellow, lobster shell pigment, is an oxidized derivative of ⁇ -carotene. Its chemical name is: 3,3′-dihydroxy-4,4′-dione ⁇ - Carotene, molecular formula C40H52O4, molecular weight For 596.86.
  • astaxanthin has the strongest antioxidant activity. Its antioxidant activity is hundreds or even thousands of times of vitamin E, thousands of times more than vitamin C. Astaxanthin is widely found in the biological world, especially in the feathers of shrimp, crab, fish, algae, yeast and birds.
  • Haematococcus pluvialis is the best organism for extracting natural astaxanthin. It has high content, strong biological activity, safe and reliable, and no toxic and side effects. Haematococcus pluvialis was included in the China New Resource Food Catalogue on October 29, 2010.
  • Electrolyte metabolism is very strong during exercise, and electrolytes are lost with sweat.
  • the electrolyte components mainly include sodium, potassium, calcium, magnesium and other trace elements.
  • Potassium deficiency affects insulin secretion, resulting in limited sugar utilization, reduced muscle blood flow, and muscle weakness and cardiac dysfunction.
  • Calcium deficiency can cause osteoporosis, rickets, muscle dysfunction, muscle spasms, and arrhythmias.
  • Magnesium deficiency affects the balance of sodium and potassium metabolism, causing potassium deficiency in cardiomyocytes, causing arrhythmia and a significant decline in exercise capacity.
  • simple hydration will further aggravate the imbalance of water and salt metabolism. Therefore, proper supplementation of electrolytes during hydration is not only beneficial to maintain the balance of body fluids, but also to maintain optimal exercise capacity.
  • the present invention provides a composition according to the weight ratio, comprising the following components: 1 to 500 parts of astaxanthin; 1 to 1000 parts of potassium salt; 1 to 500 parts of calcium salt; 1 to 500 parts of magnesium salt; 1 to 5000 parts of salt.
  • the astaxanthin comprises However, it is not limited to food grade Haematococcus pluvialis and its extract, and the weight ratio of the Haematococcus pluvialis and its extract is divided into an amount containing astaxanthin
  • the potassium salt includes but is not limited to food.
  • Grade potassium chloride including but not limited to food grade sodium chloride, sodium carbonate, sodium bicarbonate, including but not limited to food grade magnesium sulfate, including but not limited to food grade carbonate calcium.
  • the composition further comprises: 1 to 100,000 parts of sugar; and 1 to 10,000 parts of vitamin C.
  • the composition comprises the following components according to the weight ratio: 1 to 400 parts of astaxanthin; 1 to 80,000 parts of sugar; 1 to 500 parts of potassium chloride; and 1 to 300 parts of calcium carbonate; 1 to 300 parts of magnesium sulfate; 1 to 5000 parts of vitamin C; 1 to 3,000 parts of sodium chloride,
  • astaxanthin is 1 to 100 parts; sugar is 50 to 8000 parts; potassium chloride is 50 to 300 parts; calcium carbonate is 1 to 200 parts; magnesium sulfate is 1 to 200 parts; vitamin C is 1 to 3000 parts; sodium chloride is 20 parts. ⁇ 1000 parts; more preferably, 1-2 parts of astaxanthin; 50-700 parts of sugar; 50-120 parts of potassium chloride; 1-20 parts of calcium carbonate; 2-40 parts of magnesium sulfate; Parts; sodium chloride 30-800 parts; most preferred, astaxanthin 2 parts; sugar 700 parts; potassium chloride 120 parts; calcium carbonate 20 parts; magnesium sulfate 40 parts; vitamin C 100 parts; .
  • the nutritional saccharides attached to the composition include, but are not limited to, glucose, maltose, fructose, and oligosaccharides; including other possible optional carriers acceptable for medicine and food. .
  • the composition further comprises caffeine, preferably the caffeine is derived from an extract of coffee beans, guarana and tea.
  • the present invention also provides the use of the above composition in the preparation of a food or pharmaceutical product which, after application of the composition to a subject, enhances the anti-fatigue ability during exercise and promotes rapid recovery of physical strength.
  • the dosage form of the food product is selected from the group consisting of a tablet, a capsule, a powder, a granule, an effervescent, a beverage, a mixture or an oral solution.
  • the invention further provides a method of combating fatigue and/or restoring fatigue, the method comprising administering to the subject a composition as described above.
  • the formula and the application provided by the invention have the advantages of significantly improving fatigue recovery after exercise, reducing inflammation, rapidly recovering physical strength, simple use, and remarkable curative effect.
  • each component synergistically promotes synergistic effects through different ways, such as energy substances and regulating substances, enhances the body's antioxidant capacity, and removes free radicals, lactic acid and the like while supplementing energy substances.
  • the product which effectively exerts the anti-fatigue effect, can quickly complement the body's consumption of carbohydrates and lost nutrients, especially during high-intensity exercise training, or when sweating in a large amount of exercise, helping to relieve the central nervous system.
  • the composition is a new composition that significantly enhances athletic performance.
  • composition of the present application may be incorporated into a pharmaceutically or food acceptable carrier, formulated into a formulation; a "pharmaceutically acceptable” or “food acceptable” or “healthically acceptable” ingredient, specifically A substance that is suitable for humans and/or animals without excessive adverse side effects (such as toxicity, irritation, and allergies), ie, has a reasonable benefit/risk ratio.
  • “Pharmaceutically acceptable carrier” refers to a carrier for the administration of a therapeutic agent, including various excipients and diluents. The term refers to pharmaceutical carriers which are not themselves essential active ingredients and which are not excessively toxic after administration.
  • the granules, oral liquids, tablets, capsules, pills, and the like can be prepared by using a pharmaceutical carrier, and can be realized by using an existing industrial production process. It is also possible to directly mix the raw materials of the composition, knead the raw materials to make them into a uniform body, and then form them by rolling and cutting into energy rods, and finally vacuum-packing, which is convenient for storage and carrying, and can be different according to needs. Energy replenishment. Accordingly, any possible modifications to the composition by the addition or subtraction of the above carriers are directed to the scope of the invention.
  • Example 1 The effervescent tablet raw material comprises the following components by weight: 2 parts of astaxanthin, 700 parts of sugar, 120 parts of potassium chloride, 20 parts of calcium carbonate, 40 parts of magnesium sulfate, 100 parts of vitamin C, chlorination 750 parts sodium.
  • This example used 100 parts of astaxanthin-containing 2% Haematococcus pluvialis microcapsule powder (containing 2 parts of astaxanthin).
  • the water-dispersible microcapsule powder prepared by embedding the Haematococcus pluvialis extract and adding the effervescent agent such as sodium bicarbonate citric acid as a raw material to prepare an effervescent tablet, can fully form this form Dispersed and dissolved into an aqueous solution, which is beneficial to the body's absorption.
  • the raw materials are all commercially available and are food grade.
  • the preparation method employed is well known in the food art.
  • Example 2 The effervescent tablet raw material comprises the following components in parts by weight: 10 parts of astaxanthin, 800 parts of sugar, 160 parts of potassium chloride, 40 parts of calcium carbonate, 80 parts of magnesium sulfate, 600 parts of vitamin C, chlorinated 800 parts of sodium.
  • the effervescent tablet was prepared by the method of Example 1.
  • Example 3 The effervescent tablet raw material comprises the following components by weight: 8 parts of astaxanthin, 50 parts of sugar, 50 parts of potassium chloride, 1 part of calcium carbonate, 2 parts of magnesium sulfate, 800 parts of vitamin C, chlorination 20 parts of sodium.
  • the effervescent tablet was prepared by the method of Example 1.
  • Example 4 The effervescent tablet raw material comprises the following components by weight: 6 parts of astaxanthin, 600 parts of sugar, 180 parts of potassium chloride, 80 parts of calcium carbonate, 1 part of magnesium sulfate, 1000 parts of vitamin C, chlorinated 30 parts of sodium.
  • the effervescent tablet was prepared by the method of Example 1.
  • Example 5 The effervescent tablet raw material comprises the following components in parts by weight: 1 part of astaxanthin, 10 parts of sugar, 1 part of potassium chloride, 100 parts of calcium carbonate, 100 parts of magnesium sulfate, 1 part of vitamin C, chlorinated 1000 parts of sodium.
  • the effervescent tablet was prepared by the method of Example 1.
  • the effervescent tablet of the present application is capable of replenishing an antioxidant in time after exercise, and the effervescent tablet can also be applied to other carriers to prepare a preparation or a solution, and can be added to health supplements and foods supplemented with energy.
  • a large amount of carbon dioxide is generated, so that the tablet rapidly disintegrates and melts, and the astaxanthin can be rapidly dispersed and evenly distributed in the solution to form a uniformly mixed solution, which is more beneficial to the human body. Absorb and achieve rapid onset of effectiveness.
  • Test materials the effervescent tablets prepared in Examples 1 to 5 were used as experimental samples, and an equal volume of caloric glucose water was used as a negative photograph;
  • Subjects 200 patients with running friends were selected to participate in the experiment with similar pulse, nearly 5 km running score, recent training plan, monthly running volume and the latest 30 km. They were randomly divided into 5 groups, and each group was randomly divided into experimental group and control group, with 20 people in each group. Two weeks before the experiment, 500 ml of the aqueous solution of the experimental sample was taken until the end of the experiment. Subjects maintained a normal diet and did not take other nutritional supplements;
  • Experimental method Taking a marathon as the official experimental day, the experimental subjects should try their best to achieve the best personal results. If they are unwell, they can give up. Collect the morning Bo (the pulse after waking up in the morning) and the data on the next day and the third day. The degree of fatigue recovery was determined by the data of the next day and the third day relative to the change of the morning data on the day of the game.
  • Partially restored morning blog is less than 10 times in the morning on the day of the match;
  • the difference between the morning blog and the morning blog was not more than 10 times.
  • the complete recovery rate of the experimental group on the next day was about 62% on average, and the complete recovery rate on the third day was about 90% on average; while the control group was completely restored the next day.
  • the average rate was about 25%, and on average, about 75% of the third day recovered completely, and the effect of restoring fatigue was significant (p ⁇ 0.05).
  • Example 1 Particularly in the formulation of Example 1, it was surprisingly found that the formulation has extremely significant anti-fatigue and rejuvenation effects.
  • the next day's recovery rate is about 73%, and the third day recovery rate is about 100%. It can significantly improve (p ⁇ 0.01) the improvement of fatigue recovery after exercise and promote rapid recovery.
  • Example 6 According to the formulation ratio of the compositions of Examples 1 to 5, liquid sports drinks of different content ratios were respectively prepared, wherein astaxanthin could be replaced by the same amount of Haematococcus pluvialis extract, and the form of the beverage was most beneficial to the human body. Absorption, is often See the energy means of improving athletic ability.
  • the raw materials are all commercially available and are food grade.
  • the beverage preparation method employed is a well-known technique in the field of food and beverage.
  • Example 6 The sports drink of Example 6 was applied to the same group of five groups of subjects of the same condition in the above manner, and it was found that the beverage of the composition also had a good anti-fatigue and/or fatigue-recovering effect in the five groups.
  • Especially in the formulation ratio of astaxanthin 2 parts; sugar 30,000 parts; potassium chloride 120 parts; calcium carbonate 20 parts; magnesium sulfate 40 parts; vitamin C 100 parts; sodium chloride 750 parts surprisingly found that Formulated with extremely significant anti-fatigue and rejuvenating properties.
  • the next day's recovery rate was about 74%, and the third-day recovery rate was about 100%. It was able to significantly improve (p ⁇ 0.01) the recovery of fatigue after exercise and promote rapid recovery.
  • Example 7 According to the formulation ratio of the compositions of Examples 1-5, different proportions of liquid sports drinks were prepared, wherein astaxanthin could be replaced by the same amount of Haematococcus pluvialis extract and added with caffeine, or When it is a coffee bean containing a considerable amount of caffeine, the effervescent tablet of Example 7 is applied to the same group of five groups of subjects having the same conditions in the same manner as described above, and the effect is applied without adding caffeine. The effect is better.
  • composition of the present invention is very suitable for fatigue recovery during exercise, ensuring the durability and endurance of exercise, and promoting the improvement of exercise performance.
  • the composition is a new energy composition capable of significantly improving exercise capacity

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Abstract

公开了一种组合物及其用途，该组合物按照重量比分，包括以下成分：虾青素1～500份；钾盐1～1000份；钙盐1～500份；镁盐1～500份；钠盐1～5000份。其中，所述虾青素包括但不限于食品级雨生红球藻及其提取物，所述钾盐包括但不限于食品级氯化钾，所述钠盐包括但不限于食品级氯化钠，碳酸钠，碳酸氢钠，所述镁盐包括但不限于食品级硫酸镁，所述钙盐包括但不限于食品级碳酸钙。上述组合物添加到具有能量增补功效的保健品和食品中，提高运动中的抗疲劳能力，并促进体力的迅速恢复。

Description

提升运动能力的能量组合物 技术领域
本发明涉及食品、药品、保健类药物技术领域，尤其涉及抗疲劳与疲劳后恢复的食品及其应用。
背景技术
人体在正常的生命氧化活动中，有机化合物发生不完全氧化就会产生自由基。正常状态下人体内抗氧化系统可有效清除掉自由基，维持机体正常代谢和自由基平衡。然而，在激烈运动或高度集中的脑力活动时，由于机体高速运转，不仅耗能大，而且代谢供能需要在短时间内消耗大量氧气，导致氧气不足而发生不完全氧化，由此会导致大量过剩自由基的产生与积累。
有研究证实：超出通常耗氧70％的代谢活动会产导致约12倍的自由基产生，当人体抗氧化系统无法及时清除由于高耗能和高耗氧状态大量产生的自由基时，这些过剩的高活性自由基会夺取细胞内的电子，造成细胞、线粒体、DNA、透明质酸等的破坏，引发肌肉肌腱关节疲劳、酸痛及炎症。因此，有必要补充抗氧化剂，减轻自由基对细胞线粒体DNA透明质酸的破坏，以实现消除疲劳，预防酸痛及炎症的目的。
虾青素(astaxanthin)，又名虾黄质、龙虾壳色素，为β-胡萝卜素的氧化衍生物，其化学名称为：3，3′-二羟基-4，4′-二酮基β-胡萝卜素，分子式C40H52O4，分子量 为596.86。
自然界，虾青素具有最强的抗氧化性。其抗氧化活性为维生素E的数百甚至上千倍，为维生素C的数千倍。虾青素广泛存在于生物界，特别是虾、蟹、鱼、藻体、酵母和鸟类的羽毛中。
雨生红球藻是目前提取天然虾青素最好的生物，其含量高、生物活性强、安全可靠、无毒副作用。雨生红球藻已于2010年10月29日被列入中国新资源食品目录。
运动中电解质代谢非常强，电解质随汗液大量流失。电解质成分主要包括钠、钾、钙、镁及其它微量元素。当人体缺钠时，会引起低血钠症和肌肉痉挛。缺钾会影响胰岛素分泌，导致糖利用受限，肌肉血流量减少，并引起肌肉无力和心脏功能紊乱。钙缺乏会造成骨质疏松症、佝偻病、肌肉功能不良、肌肉痉挛、心律失常。镁缺乏会影响钠钾代谢平衡使心肌细胞缺钾，造成心律失常，运动能力大幅下降。运动过程中/后，单纯补水会进一步加剧水盐代谢的失衡，因此，补水时适当补充电解质不仅有利于维持体液的平衡，也有利于保持最佳的运动能力。
发明内容
本发明针对上述问题，提供了如下的技术方案：
本发明提供了一种组合物，该组合物按照重量比分，包括以下成分：虾青素1～500份；钾盐1～1000份；钙盐1～500份；镁盐1～500份；钠盐1～5000份。其中，所述虾青素包括 但不限于食品级雨生红球藻及其提取物,所述雨生红球藻及其提取物的重量比分为其含有相当的虾青素的量，而所述钾盐包括但不限于食品级氯化钾，所述钠盐包括但不限于食品级氯化钠，碳酸钠，碳酸氢钠，所述镁盐包括但不限于食品级硫酸镁，所述钙盐包括但不限于食品级碳酸钙。
在本发明一个优选的实施方式中，该组合物进一步包括：糖分1～100000份；维生素C1～10000份。
在本发明一个优选的实施方式中，该组合物按照重量比分，包括以下成分：虾青素1～400份；糖分1～80000份；氯化钾1～500份；碳酸钙1～300份；硫酸镁1～300份；维生素C 1～5000份；氯化钠1～3000份，
优选的，虾青素1～100份；糖分50～8000份；氯化钾50～300份；碳酸钙1～200份；硫酸镁1～200份；维生素C 1～3000份；氯化钠20～1000份；更优选的，虾青素1～2份；糖份50～700份；氯化钾50～120份；碳酸钙1～20份；硫酸镁2～40份；维生素C 1～200份；氯化钠30～800份；最优选的，虾青素2份；糖分700份；氯化钾120份；碳酸钙20份；硫酸镁40份；维生素C 100份；氯化钠750份。
在本发明一个优选的实施方式中，所述组合物中所附属的营养糖类包括但不限于葡萄糖、麦芽糖、果糖、及低聚糖类；包括医药与食品可接受的其他可能的任选载体。
在本发明一个优选的实施方式中，所述组合物中还包含咖啡因，优选所述咖啡因来自咖啡豆，瓜拉纳及茶等提取物。
本发明同时提供了上述组合物在制备如下食品或药品中的用途，所述用途为对受试者施用所述组合物后，提高运动中的抗疲劳能力，并促进体力的迅速恢复。
在本发明一个优选的实施方式中，其食品的剂型选自片剂、胶囊剂、粉剂、颗粒剂、泡腾剂、饮料、合剂或口服液。
本发明另外提供了一种抗疲劳和/或恢复疲劳的方法，所述方法包括对受试者施用上述组合物。
本发明提供的配方和用途，具有显著改善运动后的疲劳恢复及减少炎症发生、迅速恢复体力、使用简单、疗效显著等优点。
本发明抗疲劳组合物中，各组分通过不同途径、协同的作用，如能量物质和调节物质协同促进增效，增强机体的抗氧能力，在补充能源物质的同时清除自由基、乳酸等代谢产物，从而有效地发挥抗疲劳的作用，能够迅速补足人体由于运动，特别的是在高强度运动训练下、或健身大量出汗时，所消耗的碳水化合物和丢失的营养素，有助于缓解中枢和骨骼疲劳，提高机体的抗氧化和有氧代谢水平，改善细胞的氧利用率，减少运动后乳酸堆积，降低运动后尿素氮数值，延缓疲劳发生和促进运动后疲劳的恢复，增进运动机能有助于快速提高机体的运动和抗疲劳能力，避免运动损伤的发生。该组合物是一种能够显著提升运动能力的新组合物。
具体实施方式
本申请的组合物可加入医药或食品能够接受的载体，研制成制剂；“药学上可接受的”或“食品学上可接受的”或“保健品学上可接受的”的成分，具体指适用于人和/或动物而无过度不良副反应(如毒性、刺激和变态反应)的，即有合理的效益/风险比的物质。“药学上可接受的载体”指用于治疗剂给药的载体，包括各种赋形剂和稀释剂。该术语指这样一些药剂载体：它们本身并不是必要的活性成分，且施用后没有过分的毒性。比如通过药物载体制成颗粒剂、口服液、片剂、胶囊、丸剂等形式，采用现有的工业化生产过程均能实现。也可直接将组合物的原料混合，揉合原料使之成为均匀体，然后通过滚压成型，并切割制成能量棒的形式，最后抽真空包装，这样方便保存和携带，可根据需要在不同的时候进行能量补给。因此，任何通过增加或减少上述载体对组合物进行的可能修正，均涉及本申请发明保护范围。
下面将根据具体实施方式对本发明进行进一步的详细说明。
实施例1：该泡腾片原料按重量份包括以下组分：虾青素2份，糖700份，氯化钾120份，碳酸钙20份，硫酸镁40份，维生素C 100份，氯化钠750份。该实施例使用含虾青素2％雨生红球藻微囊粉100份(含虾青素2份)。将雨生红球藻提取物经包埋后制成的水分散性微胶囊粉末，并将粉末颗粒作为原料添加碳酸氢钠柠檬酸等泡腾剂制成泡腾片，这种形式的能够充分分散溶解到水溶液中，利于人体吸收。所述原料均为市售购得，并为食品级。所采用的制备方法为食品领域公知技术。
实施例2：该泡腾片原料按重量份包括以下组分：虾青素10份，糖800份，氯化钾160份，碳酸钙40份，硫酸镁80份，维生素C 600份，氯化钠800份，。泡腾片采用实施例1中的方法制备。
实施例3：该泡腾片原料按重量份包括以下组分：虾青素8份，糖50份，氯化钾50份，碳酸钙1份，硫酸镁2份，维生素C 800份，氯化钠20份。泡腾片采用实施例1中的方法制备。
实施例4：该泡腾片原料按重量份包括以下组分：虾青素6份，糖600份，氯化钾180份，碳酸钙80份，硫酸镁1份，维生素C 1000份，氯化钠30份。泡腾片采用实施例1中的方法制备。
实施例5：该泡腾片原料按重量份包括以下组分：虾青素1份，糖10份，氯化钾1份，碳酸钙100份，硫酸镁100份，维生素C 1份，氯化钠1000份。泡腾片采用实施例1中的方法制备。
本申请中的泡腾片能够在运动中运动后，及时补充抗氧化剂，该泡腾片还能够应用于其他载体制成制剂或者溶液，并可添加到补充能量的保健品和食品中。通过泡腾片特有的在水的作用下电离，产生大量的二氧化碳，使得片剂迅速崩解和融化，能够让虾青素迅速分散均布在溶液中，形成混合均匀的溶液，更加有利于人体吸收，实现迅速起效的目的。
为检验本发明的用于运动期间补充抗氧化剂和电解质的泡腾片对运动人群的运动疲劳恢复效果，进行了如下实验：
1、受试材料：以实施例1～5中制得的泡腾片为实验样品，以等体积等热量葡萄糖水为对阴性照样品；
2、受试对象：选取脉搏相近，近5公里跑成绩、近期训练计划、月跑量及最近30公里成绩为条件筛选出跑友200人参加实验。随机分为5组，每组中再随机分为实验组和对照组，每组20人。实验前两周开始服用实验样品一份所制水溶液500ml，直至实验结束。受试对象维持普通饮食，不服用其他营养补剂；
3、实验方法：以某马拉松赛为正式实验日，实验对象需尽力以创个人最好成绩为目标跑完，途中如遇不适，可放弃。收集当日晨博(清晨睡醒后脉搏)及次日、第三日晨博数据。以次日及三日数据相对于比赛当日晨博数据变化来判定疲劳恢复程度。
恢复程度判定标准：
完全恢复晨博相对于比赛当日晨博差异在5次内；
部分恢复晨博相对于比赛当日晨博差异在10次内；
未恢复晨博相对于比赛当日晨博差异在10次以上。
4、实施效果：(恢复率仅采用完全恢复晨博的进行计算)
Figure PCTCN2016083942-appb-000001
Figure PCTCN2016083942-appb-000002
结果经单因素方差分析可看出：
在实施例2～4的配方下，第二至第五组中，实验组次日完全恢复率平均约为62％，第三日完全恢复率平均约为90％；而对照组次日完全恢复率平均约为25％，第三日平均约75％完全恢复，恢复疲劳的作用显著(p<0.05)。
尤其在实施例1的配方下，令人惊奇的发现，该配方具有极显著的抗疲劳和恢复体力的功效。次日恢复率约为73％，第三日恢复率约为100％，能够极显著(p<0.01)改善运动后的疲劳恢复及促进迅速恢复体力。
实施例6：按照实施例1～5的组合物配方比例，分别制备不同含量比例的液体运动饮料，其中虾青素可用含有同样量的雨生红球藻提取物替换，饮料的形式最利于人体吸收，是常 见的提升运动能力的能量手段。所述原料均为市售购得，并为食品级。所采用的饮料制备方法为食品饮料领域的公知技术。
将实施例6中的运动饮料以上述方法施用于同样分组的五组同样条件的受试对象，发现在这五组中该组合物饮料同样有很好的抗疲劳和/或恢复疲劳的作用。尤其在配方比例为虾青素2份；糖分30000份；氯化钾120份；碳酸钙20份；硫酸镁40份；维生素C 100份；氯化钠750份时，令人惊奇地发现，该配方具有极显著的抗疲劳和恢复体力的功效。次日恢复率约为74％，第三日恢复率约为100％，能够极显著(p<0.01)改善运动后的疲劳恢复及促进迅速恢复体力。
实施例7：按照实施例1～5的组合物配方比例，分别制备不同含量比例的液体运动饮料，其中虾青素可用含有同样量的雨生红球藻提取物替换，并加入咖啡因，或是含有相当量的咖啡因的咖啡豆时，并将实施例7中的泡腾片以上述方法施用于同样分组的五组同样条件的受试对象，施用到效果相比不添加咖啡因的，效果更佳。
上述实验表明，本发明的组合物非常适合用于运动期间的疲劳恢复，保证了运动的持久性和耐力，对提高运动成绩，有促进作用。该组合物是一种能够显著提升运动能力的新能量组合物
以上所述，仅是本发明较佳实施例而已，并非对本发明作任何形式上的限制，虽然本发明以较佳实施例揭露如上，然而并非用以限定本发明，任何熟悉本专业的技术人员，在不脱离本发明技术方案范围内，当可利用上述揭示的技术内容做出些许变更或修饰为等同 变化的等效实施例，但凡是未脱离本发明技术方案内容，依据本发明技术是指对以上实施例所作的任何简单修改、等同变化与修饰，均属于本发明技术方案的范围内。

Claims (8)

  1. 一种组合物，其特征在于，该组合物按照重量比分，住要包括以下成分：虾青素1～500份；钾盐1～1000份；钙盐1～500份；镁盐1～500份；钠盐1～5000份，其中，所述虾青素包括但不限于食品级雨生红球藻及其提取物,所述雨生红球藻及其提取物的重量比分为其含有相当的虾青素的量，而所述的钾盐包括但不限于食品级氯化钾，所述的钠盐包括但不限于食品级氯化钠，碳酸钠，碳酸氢钠，所述的镁盐包括但不限于食品级硫酸镁，所述的钙盐包括但不限于食品级碳酸钙。
  2. 根据权利要求1所述组合物，其特征在于，该组合物还包括：糖分1～100000份；维生素C 1～10000份。
  3. 根据权利要求2所述组合物，其特征在于，该组合物按照重量比分，包括以下成分：虾青素1～400份；糖分1～80000份；氯化钾1～500份；碳酸钙1～300份；硫酸镁1～300份；维生素C 1～5000份；氯化钠1～3000份，
    优选的，虾青素1～100份；糖分50～8000份；氯化钾50～300份；碳酸钙1～200份；硫酸镁1～200份；维生素C 1～3000份；氯化钠20～1000份；更优选的，虾青素1～2份；糖份50～700份；氯化钾50～120份；碳酸钙1～20份；硫酸镁2～40份；维生素C 1～200份；氯化钠30～800份；最优选的，虾青素2份；糖分700份；氯化钾120份；碳酸钙20份；硫酸镁40份；维生素C 100份；氯化钠750份。
  4. 根据权利要求1～3中任一项所述组合物，其特征在于，所述组合物中所述糖类包括 但不限于葡萄糖、麦芽糖、果糖及低聚糖类；任选包括医药和/或食品可接受的载体。
  5. 据求1～3任一项的组合物，其特征在于，所述组合物中还包含咖啡因，优选所述咖啡因来自咖啡豆、瓜拉纳及茶等提取物。
  6. 权利要求1～5任一项的组合物其特征在于，用于制备如下功效的食品或药品中，并进行商业开发，对受试者施用所述组合物后，可提高运动中的抗疲劳能力，并促进体力的迅速恢复。
  7. 权利要求1～5一项的组合物所生产的相关制品，包括但不限于片剂、胶囊剂、粉剂、颗粒剂、泡腾剂、饮料、合剂或口服液，饮料。
  8. 一种抗疲劳和/或恢复疲劳的方法，所述方法包括对受试者施用权利要求1～5任一项的组合物。
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CN111972586A (zh) * 2020-08-17 2020-11-24 同方药业集团有限公司 一种虾青素营养素固体饮料
CN112931740A (zh) * 2021-04-08 2021-06-11 云南爱尔康生物技术有限公司 一种雨生红球藻天然运动饮料及其制备方法
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CN105193842A (zh) * 2015-11-05 2015-12-30 阿士力(深圳)运动健康科技有限公司 一种补充抗氧化剂的泡腾片及其应用

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CN109198621A (zh) * 2018-09-30 2019-01-15 徐州统食品工业有限公司 一种可提高运动能力的组合物及其制备方法
EP3934628A4 (en) * 2019-03-03 2022-12-14 Algatechnologies Ltd. COMPOSITIONS COMPRISING SEAWEED POWDER AND THEIR USES
CN111972586A (zh) * 2020-08-17 2020-11-24 同方药业集团有限公司 一种虾青素营养素固体饮料
CN112931740A (zh) * 2021-04-08 2021-06-11 云南爱尔康生物技术有限公司 一种雨生红球藻天然运动饮料及其制备方法

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