WO2017185473A1 - 一种义齿材料组合物 - Google Patents

一种义齿材料组合物 Download PDF

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WO2017185473A1
WO2017185473A1 PCT/CN2016/084133 CN2016084133W WO2017185473A1 WO 2017185473 A1 WO2017185473 A1 WO 2017185473A1 CN 2016084133 W CN2016084133 W CN 2016084133W WO 2017185473 A1 WO2017185473 A1 WO 2017185473A1
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Prior art keywords
denture material
denture
composition
material according
plasticizer
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PCT/CN2016/084133
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English (en)
French (fr)
Inventor
刘谋山
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成都贝施美医疗设备有限公司
成都贝施美生物科技有限公司
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Publication of WO2017185473A1 publication Critical patent/WO2017185473A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
    • A61K6/802—Preparations for artificial teeth, for filling teeth or for capping teeth comprising ceramics
    • A61K6/813—Preparations for artificial teeth, for filling teeth or for capping teeth comprising ceramics comprising iron oxide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
    • A61K6/802—Preparations for artificial teeth, for filling teeth or for capping teeth comprising ceramics
    • A61K6/818—Preparations for artificial teeth, for filling teeth or for capping teeth comprising ceramics comprising zirconium oxide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
    • A61K6/884—Preparations for artificial teeth, for filling teeth or for capping teeth comprising natural or synthetic resins
    • A61K6/887—Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
    • A61K6/884—Preparations for artificial teeth, for filling teeth or for capping teeth comprising natural or synthetic resins
    • A61K6/891—Compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds

Definitions

  • the present invention belongs to the field of medical materials, and in particular relates to a composition of a denture material.
  • Dentures are what people often call “dentures.” Just like “prosthetic legs” and “prosthetic limbs” are called “prosthetic limbs”, “dentures” mean teeth that are "obligatory” for human beings. Medically, it is a general term for restorations made after missing some or all of the upper and lower teeth. Dentures are divided into three types: pickable, fixed and implanted. Fixed dentures (commonly known as “fixed dentures”) cannot be worn by the patient themselves, and removable dentures (commonly known as “active dentures”) can be easily accessed by the patient. Dental implants are a relatively fast and new technology developed in recent years. The method is to implant implants in the alveolar bone.
  • the implants are implanted on the implants, but the implants require the patient to be fully implanted.
  • Good health, alveolar bone has a certain height and width.
  • Dental implants are comfortable and beautiful, do not damage adjacent teeth, but are more expensive.
  • the denture materials currently on the market are made of dentures due to the composition, and the color of the dentures becomes blue, yellow and yellow, which is ugly and affects the appearance. Especially the cyan in the resin tooth, the dark color is the most difficult thing for the engineer who makes the denture work, it is difficult to exclude the cyan and the dark color in the denture.
  • the small molecule component such as a plasticizer in the acrylate denture material overflows, the water absorption of the polymer can be accompanied by the polymer, and the material loses elasticity and the denture is deformed, so how to reduce the overflow of the plasticizer and reduce
  • the water absorption and dissolution rate of acrylate materials are key to improving the properties of the material.
  • a composition of denture material consisting of the following weight fractions of raw materials:
  • methyl polymethyl acrylate monomer 75 ⁇ 100
  • thermosetting dental powder 85 ⁇ 100
  • polysulfone resin 0.05 ⁇ 0.1; plasticizer: 0.2 ⁇ 0.3; [0009] Tooth pigment: 1.5 ⁇ 3.5; Zirconia: 5 ⁇ 15.
  • methyl polymethyl acrylate monomer 90; thermosetting dental powder: 95;
  • polysulfone resin 0.08; plasticizer: 0.25;
  • Tooth pigment 2. 5; Zirconia: 9.5.
  • thermosetting denture powder is polymethyl methacrylate; the plasticizer is a phthalate; the dentin is zinc oxide, iron oxide, cerium oxide or oxidation. cobalt.
  • the phthalic acid ester is dimethyl phthalate or di(2-ethylhexyl) phthalate.
  • the denture hardness of the denture material reaches 14.8 GPa.
  • the denture material has a three-point bending strength of 1116 to 1254 MPa.
  • the amount of water absorption of the denture material is 2.67 ⁇ 3 ⁇ 4 ⁇ 3.25 ⁇ 3 ⁇ 4.
  • the present invention has the following advantages:
  • the present invention provides a composition of a denture material in which a thermosetting denture powder and zirconia are added, and for the acrylate, the remaining monomer is less, and the polymer is absorbed.
  • the dissolution of water and plasticizers and the like is relatively small; in the present invention, the dentin pigment is added, and the tooth color required for the dental patient can be prepared to meet the requirements of the patient; the present invention further improves the parameters of the denture material composition, and achieves the most Excellent effect;
  • the denture made by the denture material composition of the invention has good simulation property, strong transparency, no discoloration of dentin, beautiful appearance, low cost and good adaptability.
  • Example 1 A composition of a denture material consisting of the following raw materials by weight:
  • methyl polymethyl acrylate monomer 75; polymethyl methacrylate: 85; polysulfone resin: 0.05;
  • dimethyl phthalate 0.2; zinc oxide: 1.5; zirconia: 5. [0024] wherein, the denture hardness of the denture material reaches 14.8 GPa; the three-point bending strength of the denture material is 1116 MPa; the water absorption of the denture material is 2.67%.
  • Example 2 A composition of a denture material consisting of the following raw materials by weight:
  • methyl polymethyl acrylate monomer 100; polymethyl methacrylate: 100; polysulfone resin: 0.1;
  • the denture hardness of the denture material reaches 14.8 GPa; the three-point bending strength of the denture material is 1254 MPa; and the water absorption of the denture material is 3.25 ⁇ 3 ⁇ 4.
  • Example 3 A composition of a denture material consisting of the following raw materials by weight:
  • methyl polymethyl acrylate monomer 90; polymethyl methacrylate: 95; polysulfone resin: 0.08;
  • Dimethyl phthalate 0.25; yttrium oxide: 2.5; zirconia: 9.5.
  • the denture hardness of the denture material reaches 14.8 GPa; the three-point bending strength of the denture material is 1180 MPa; and the water absorption of the denture material is 2.95%.
  • Example 4 A composition of denture material consisting of the following parts by weight of raw materials:
  • methyl polymethyl acrylate monomer 80; polymethyl methacrylate: 90; polysulfone resin: 0.06;
  • the denture hardness of the denture material reaches 14.8 GPa; the three-point bending strength of the denture material is 1200 MPa; and the water absorption of the denture material is 3.11%.

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  • Health & Medical Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Plastic & Reconstructive Surgery (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Ceramic Engineering (AREA)
  • Engineering & Computer Science (AREA)
  • Dental Preparations (AREA)
  • Dental Prosthetics (AREA)

Abstract

一种义齿材料的组合物，由以下重量份的原料制备而成：甲基丙烯酸甲酯 75-10、热凝牙托粉 85-100、聚砜树脂 0.05-0.1、增塑剂 0.2-0.3、造牙色素 1.5-3.5和氧化锆 5-15。

Description

说明书 发明名称：一种义齿材料组合物
技术领域
[0001] 本发明属于医用材料领域， 具体涉及一种义齿材料的组合物。
背景技术
[0002] 义齿就是人们常说的 "假牙"。 就像把 "假腿"、 "假肢"称为"义肢"一样， "义齿" 的意思就是指为人类尽"义务"的牙齿。 医学上是对上、 下颌牙部分或全部牙齿缺 失后制作的修复体的总称。 义齿分为可摘、 固定和种植牙三种。 固定义齿 （俗 称"固定假牙"） 是不能由患者自己取戴的， 而可摘义齿 （俗称"活动假牙"） 可以 由患者方便地取戴。 种植牙是近年来发展较快较新的技术， 方法是在牙槽骨内 植入种植体， 待种植体与牙槽骨形成骨结合后， 再在种植体上镶牙， 但种植牙 要求患者全身健康状况好， 牙槽骨有一定的高度和宽度。 种植牙使用舒适美观 ， 不损伤邻牙， 但价格较贵。
[0003] 目前市场上的义齿材料由于成分的原因， 制作成的假牙其色泽会变得发青、 发 阴发黄色， 比较难看， 影响美观。 尤其是树脂牙体内的青色， 阴色是制作假牙 工作的工程师最困难的事情， 很难排除假牙里的青色和阴色。
[0004] 丙烯酸酯类义齿材料中的增塑剂等小分子成分溢出后， 可同吋伴有聚合物的 水吸收， 此吋材料失去弹性， 义齿变形， 因而如何减少增塑剂的溢出， 降低丙 烯酸酯类材料的吸水率和溶解率是改善该材料性能的关键。
技术问题
[0005] 本发明的目的在于克服现有技术的缺点， 提供一种义齿材料的组合物。
问题的解决方案
技术解决方案
[0006] 本发明的目的通过以下技术方案来实现： 一种义齿材料的组合物， 它由下述重 量份的原料组成：
[0007] 甲基聚丙烯酸甲酯单体： 75〜100； 热凝牙托粉： 85〜100；
[0008] 聚砜树脂： 0.05〜0.1； 增塑剂： 0.2〜0.3； [0009] 造牙色素： 1.5〜3.5； 氧化锆： 5〜15。
[0010] 进一步地， 它由下述重量份的原料组成：
[0011] 甲基聚丙烯酸甲酯单体： 90; 热凝牙托粉： 95;
[0012] 聚砜树脂： 0.08; 增塑剂： 0.25;
[0013] 造牙色素： 2.5； 氧化锆： 9.5。
[0014] 进一步地， 所述热凝牙托粉为聚甲基丙烯酸甲酯； 所述增塑剂为邻苯二甲酸 酯类； 所述造牙色素为氧化锌、 氧化铁、 氧化铒或氧化钴。
[0015] 进一步地， 所述邻苯二甲酸酯类为邻苯二甲酸二甲酯或邻苯二甲酸二 （2-乙 基己） 酯。
[0016] 进一步地， 所述义齿材料的维氏硬度达到 14.8GPa。
[0017] 进一步地， 所述义齿材料的三点抗弯强度为 1116〜1254MPa。
[0018] 进一步地， 所述义齿材料的吸水量为 2.67<¾〜3.25<¾。
发明的有益效果
有益效果
[0019] 本发明具有以下优点： 本发明提供一种义齿材料的组合物， 该组合物中加入热 凝牙托粉和氧化锆， 对于丙烯酸酯类来说其剩余单体较少， 聚合物吸收水和增 塑剂等的溶解相对较少； 本发明中加入造牙色素， 可制作成牙科患者需要的牙 色， 满足患者的要求； 本发明进一步完善了义齿材料组合物的参数， 达到了最 优的效果； 采用本发明的义齿材料组合物制作的假牙仿真性好、 透明性强、 牙 质不变色、 美观大方、 造价低、 适应性好。
本发明的实施方式
[0020] 下面结合实施例对本发明做进一步的描述， 本发明的保护范围不局限于以下所 述。
[0021] 实施例 1: 一种义齿材料的组合物， 它由下述重量份的原料组成：
[0022] 甲基聚丙烯酸甲酯单体： 75; 聚甲基丙烯酸甲酯： 85; 聚砜树脂： 0.05;
[0023] 邻苯二甲酸二甲酯： 0.2; 氧化锌： 1.5; 氧化锆： 5。 [0024] 其中， 所述义齿材料的维氏硬度达到 14.8GPa; 所述义齿材料的三点抗弯强 度为 1116MPa; 所述义齿材料的吸水量为 2.67%。
[0025] 实施例 2: —种义齿材料的组合物， 它由下述重量份的原料组成：
[0026] 甲基聚丙烯酸甲酯单体： 100; 聚甲基丙烯酸甲酯： 100; 聚砜树脂： 0.1 ;
[0027] 邻苯二甲酸二 （2-乙基己） 酯： 0.3 ; 氧化铁： 3.5 ; 氧化锆： 15。
[0028] 其中， 所述义齿材料的维氏硬度达到 14.8GPa; 所述义齿材料的三点抗弯强 度为 1254 MPa; 所述义齿材料的吸水量为 3.25<¾。
[0029] 实施例 3: —种义齿材料的组合物， 它由下述重量份的原料组成：
[0030] 甲基聚丙烯酸甲酯单体： 90; 聚甲基丙烯酸甲酯： 95 ; 聚砜树脂： 0.08 ;
[0031] 邻苯二甲酸二甲酯： 0.25 ; 氧化铒： 2.5 ; 氧化锆： 9.5。
[0032] 其中， 所述义齿材料的维氏硬度达到 14.8GPa; 所述义齿材料的三点抗弯强 度为 1180MPa; 所述义齿材料的吸水量为 2.95%。
[0033] 实施例 4一种义齿材料的组合物， 它由下述重量份的原料组成：
[0034] 甲基聚丙烯酸甲酯单体： 80; 聚甲基丙烯酸甲酯： 90; 聚砜树脂： 0.06;
[0035] 邻苯二甲酸二 （2-乙基己） 酯： 0.28； 氧化钴： 3.2； 氧化锆： 12。
[0036] 其中， 所述义齿材料的维氏硬度达到 14.8GPa; 所述义齿材料的三点抗弯强 度为 1200MPa; 所述义齿材料的吸水量为 3.11%。

Claims

权利要求书
[权利要求 1] 一种义齿材料的组合物， 其特征在于， 它由下述重量份的原料组成： 甲基聚丙烯酸甲酯单体： 75〜100； 热凝牙托粉：
85〜100；
聚砜树脂： 0.05〜0.1； 增塑剂： 0.2〜0.3；
造牙色素： 1.5〜3.5； 氧化锆： 5〜15。
[权利要求 2] 如权利要求 1所述的一种义齿材料的组合物， 其特征在于， 它由下述 重量份的原料组成：
甲基聚丙烯酸甲酯单体： 90; 热凝牙托粉： 95;
聚砜树脂： 0.08; 增塑剂： 0.25;
造牙色素： 2.5; 氧化锆： 9.5。
[权利要求 3] 如权利要求 1所述的一种义齿材料的组合物， 其特征在于， 所述热凝 牙托粉为聚甲基丙烯酸甲酯； 所述增塑剂为邻苯二甲酸酯类； 所述造 牙色素为氧化锌、 氧化铁、 氧化铒或氧化钴。
[权利要求 4] 如权利要求 1或 3所述的一种义齿材料的组合物， 其特征在于， 所述邻 苯二甲酸酯类为邻苯二甲酸二甲酯或邻苯二甲酸二 （2-乙基己） 酯。
[权利要求 5] 如权利要求 1所述的一种义齿材料的组合物， 其特征在于， 所述义齿 材料的维氏硬度达到 14.8GPa。
[权利要求 6] 如权利要求 1所述的一种义齿材料的组合物， 其特征在于， 所述义齿 材料的三点抗弯强度为 1116〜1254MPa。
[权利要求 7] 如权利要求 1所述的一种义齿材料的组合物， 其特征在于， 所述义齿 材料的吸水量为 2.67<¾〜3.25<¾。
PCT/CN2016/084133 2016-04-29 2016-05-31 一种义齿材料组合物 WO2017185473A1 (zh)

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CN106389132A (zh) * 2016-11-01 2017-02-15 东莞市爱嘉义齿有限公司 一种义齿树脂基托材料及其制备方法
CN106511102A (zh) * 2016-11-03 2017-03-22 中国科学院兰州化学物理研究所 一种新型口腔义齿材料及其制备方法
CN109265164A (zh) * 2018-09-11 2019-01-25 佛山市佛冠义齿有限公司 一种用于制备义齿材料的组合物

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CN103340754A (zh) * 2013-06-05 2013-10-09 河北工业大学 氧化锆纳米管增强牙托粉的制备方法
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CN105107025B (zh) * 2015-09-11 2018-06-15 上海沪亮生物医药科技有限公司 一种有机/无机复合材料及其制备方法和在义齿制作中的用途

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CN103340754A (zh) * 2013-06-05 2013-10-09 河北工业大学 氧化锆纳米管增强牙托粉的制备方法
CN105287232A (zh) * 2015-11-16 2016-02-03 毕相廷 一种义齿材料的组合物

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