WO2017184104A1 - Système d'administration de médicament - Google Patents

Système d'administration de médicament Download PDF

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Publication number
WO2017184104A1
WO2017184104A1 PCT/US2016/028058 US2016028058W WO2017184104A1 WO 2017184104 A1 WO2017184104 A1 WO 2017184104A1 US 2016028058 W US2016028058 W US 2016028058W WO 2017184104 A1 WO2017184104 A1 WO 2017184104A1
Authority
WO
WIPO (PCT)
Prior art keywords
membrane
drug delivery
delivery device
housing
sidewall
Prior art date
Application number
PCT/US2016/028058
Other languages
English (en)
Inventor
Ronald A. Durando
Original Assignee
Mphase Technologies, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mphase Technologies, Inc. filed Critical Mphase Technologies, Inc.
Priority to PCT/US2016/028058 priority Critical patent/WO2017184104A1/fr
Publication of WO2017184104A1 publication Critical patent/WO2017184104A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M35/00—Devices for applying media, e.g. remedies, on the human body
    • A61M35/10—Wearable devices, e.g. garments, glasses or masks

Definitions

  • the present invention relates generally to a non-pump enabled drug delivery device and more specifically it relates to a drug delivery system for automatically dispensing a pre-set dosage of a drug agent or medication.
  • Description of the Related Art Any discussion of the related art throughout the specification should in no way be considered as an admission that such related art is widely known or forms part of common general knowledge in the field.
  • Many individuals in present times require routine application of various medication and drug agents. For example, individuals afflicted with diabetes require routine injections or applications of insulin to maintain proper blood sugar levels. Other individuals require routine application of medicated creams and the like to treat various skin conditions. In the past, such individuals have been required to manually measure out the required amount of the medication prior to manually applying the medication, such as by applying to the skin or via injection.
  • the invention generally relates to a drug delivery system which includes a housing including one or more reservoirs; each having a medical agent hermetically sealed therein.
  • a membrane extends across each of the one or more reservoirs which is adapted to allow the medical agents to pass therethrough in response to external stimuli, such as physical puncturing, melting the membranes through use of heating elements or electrowetting in response to a voltage pulse.
  • a wicking material extends across the membranes through which the medical agents are dispensed to a patient.
  • FIG. 1 is an upper perspective view of a first embodiment of the present invention in use.
  • FIG. 2 is a rear upper perspective view of a first embodiment of the present invention.
  • FIG. 3 is a rear view of a first embodiment of the present invention illustrating conduit pathing through the membrane.
  • FIG. 4 is a frontal view of the present invention.
  • FIG. 5 is a side sectional view of a first embodiment of the present invention.
  • FIG. 6 is a side sectional view of a first embodiment of the present invention dispensing a medical agent.
  • FIG. 7 is a rear view of a first embodiment of the present invention illustrating the usage of heating elements.
  • FIG. 8 is a side sectional view of a first embodiment of the present invention illustrating the usage of heating elements.
  • FIG. 9 is a rear upper perspective view of a second embodiment of the present invention.
  • FIG. 10 is a side sectional view of a second embodiment of the present invention.
  • FIG. 11 is a rear view of a second embodiment of the present invention illustrating usage of heating elements.
  • FIG. 12 is a side sectional view of a second embodiment of the present invention illustrating usage of heating elements.
  • FIGS. 1 through 12 illustrate a drug delivery system 10, which comprises a housing 20 including one or more reservoirs 30, 34, 37; each having a medical agent 31a, 31b, 31c hermetically sealed therein.
  • a membrane 40, 43, 46 extends across each of the one or more reservoirs 30, 34, 37 which is adapted to allow the medical agents 31a, 31b, 31c to pass therethrough in response to external stimuli, such as physical puncturing, melting the membranes 40, 43, 46 through use of heating elements 41, 44, 47 or electrowetting in response to a voltage pulse.
  • a wicking material 50 extends across the membranes 40, 43, 46 through which the medical agents 31a, 31b, 31c are dispensed to a patient.
  • the present invention generally comprises a housing 20 which acts to store and dispense a predetermined amount of a medicated agent 31 in response to external stimulus.
  • the shape, structure and configuration of the housing 20 may vary widely in different embodiments of the present invention.
  • the rectangular housing 20 shown in the accompanying figures should not be construed as being limiting on the scope of the present invention as different shapes could be utilized for different embodiments.
  • the housing 20 will be comprised of an upper wall 22, a first sidewall 24 and a second sidewall 26.
  • the walls 22, 24, 26 of the housing 20, in combination with the membrane 40, define a reservoir 30 adapted to store the medical agent 31 to be dispensed using the present invention.
  • the walls 22, 24, 26 may be comprised of various materials which are capable of hermetically sealing the medical agent 31 within the reservoir 30 defined within the housing 20.
  • a single membrane 40 extends between the first sidewall 24 and second sidewall 26 to define the reservoir 30 in which the medical agent 31 is sealed.
  • the volume of the reservoir 30, and thus the positioning of the membrane 40 on the sidewalls 24, 26, will vary depending on the application of the present invention.
  • the specific construction of the membrane 40 will vary and is discussed in the following section of the present application.
  • the housing 20 will generally include a fill hole 32 and a triggering member 33 as shown in FIG. 2.
  • the fill hole 32 is utilized to fill the reservoir 30 with the medical agent 31 to be applied with the present invention.
  • the triggering member 33 is generally comprised of an electrode or other device which is utilized to provide the relevant stimulus to allow the medical agent 31 to pass through the membrane 40 and out through the wicking material 50 as discussed in more detail below.
  • the positioning of the fill hole 32 and triggering member 33 may vary for different embodiments and thus should not be construed as being limited by the exemplary embodiments shown in the figures.
  • FIGS. 9 - 12 illustrate an alternate embodiment of the present invention which utilizes multiple reservoirs 30, 34, 37, each storing a separate medical agent 31a, 31b, 31c. While the figures only illustrate embodiments including one or three reservoirs 30, 34, 37, it is appreciated that varying numbers of reservoirs 30, 34, 37 may be included with the present invention in different embodiments.
  • the present invention should not be construed as being limited to these exemplary configurations, as some embodiments may include two reservoirs 30, 34 or four or more reservoirs 30, 34, 37 if needed. By utilizing multiple reservoirs 30, 34, 37, the present invention may accommodate storage and dispensing of different types of medical agents 31a, 31b, 31c within a single housing 20.
  • the housing 20 includes a first divider wall 28 extending from a first point on the upper wall 22 and a second divider wall 29 extending from a second point on the upper wall 22 to define three discrete reservoirs 30, 34, 37 as shown in FIG. 10.
  • the housing 20 will include a first fill hole 32 and first triggering member 33 adjacent the first reservoir 30, a second fill hole 35 and second triggering member 36 adjacent the second reservoir 34 and a third fill hole 38 and third triggering member 39 adjacent the third reservoir 37.
  • the different fill holes 32, 35, 38 may individually be utilized to fill each reservoir 30, 34, 37 with a different medical agent 31a, 31b, 31c.
  • the different triggering members 33, 36, 39 may be utilized to allow each medical agent 31a, 31b, 31c to pass through each of the three discrete membranes 40, 43, 46 in such an embodiment.
  • a single membrane 40 extends between the first sidewall 24 and second sidewall 26 of the housing 20.
  • a first membrane 40 extends between the first sidewall 24 and first divider wall 28
  • a second membrane 42 extends between the first divider wall 28 and second divider wall 29
  • a third membrane 46 extends between the second divider wall 29 and second sidewall 26 of the housing 20.
  • each membrane 40, 43, 46 may be separately activated to dispense a different medical agent 31a, 31b, 31c.
  • the membranes 40, 43, 46 of the present invention may vary in different embodiments as to the type of external stimulus necessary to allow the medical agent 31 to pass therethrough.
  • the membrane(s) 40, 43, 46 will be comprised of a porous, hydrophobic membrane 31 which is adapted to prevent the medical agent 31 to pass therethrough absent external stimulus.
  • a voltage pulse may be applied to the membrane(s) 40, 43, 46 through use of the triggering member(s) 33, 36, 39 which causes a transition of the surface properties of the membrane(s) 40, 43, 46 and medical agent(s) 31a, 31b, 31c. This transition results in the membrane(s) 40, 43, 46 losing their repelling properties and thus allowing the medical agent(s) 31a, 31b, 31c to pass through the porous regions of the membrane(s) 40, 43, 46 and into the wicking material 50 to be dispensed to the patient.
  • conduit 12 is incorporated within the membrane(s) 40, 43, 46 through which the voltage pulse will be applied to the membrane(s) 40, 43, 46.
  • the conduit 12 will be electrically connected to the trigger(s) 33, 36, 39 so that the voltage pulses may be transferred from the trigger(s) 33, 36, 39 to the membrane(s) 40, 43, 46 to electrically activate the same.
  • the membrane(s) 40, 43, 46 may be physically punctured such as by rupturing, puncturing or tearing the membrane(s) 40, 43, 46 using a physical trigger 33, 36, 39 such as a pin or similar structure.
  • some embodiments may allow the housing 20 to be twisted to break the membrane(s) 40, 43, 46.
  • one or more heating elements 41, 44, 47 may be utilized to melt the membrane(s) 40, 43, 46.
  • a first heating element 41 will be incorporated into the first membrane 40
  • a second heating element 44 will be incorporated into the second membrane 43
  • a third heating element 47 will be incorporated into the third membrane 46.
  • the heating elements 41, 44, 47 will act to melt the membranes 40, 43, 46 in response to electrical or other stimulus initiated at the triggers 33, 36, 39 and transferred via conduit 12 to the heating elements 41, 44, 47.
  • the membranes 40, 43, 46 melt the stored medical agents 31a, 31b, 31c will pass therethrough and into the wicking material 50.
  • D. Wicking Material D.
  • a wicking material 50 extends below the membrane(s) 40, 43, 46 of the present invention.
  • the wicking material 50 may be comprised of any material capable of passing the medical agents 31a, 31b, 31c therethrough to be applied to the patient.
  • three discrete wicking materials 50 will be utilized, each separated by the divider walls 28, 29, to prevent cross-contamination of the medical agents 31a, 31b, 31c when dispensed.
  • the medical agents 31a, 31b, 31c are injected into the reservoirs 30, 34, 37 through the fill holes 32, 35, 38 on the upper wall 22 of the housing 20.
  • the triggers 33, 36, 39 are activated to cause the medical agents 31a, 31b, 31c to pass through the membranes 40, 43, 46 and into the wicking material 50 to be dispensed to the patient.
  • the wicking material 50 may be in direct contact with the patient's skin, if the medication can be absorbed through surface contact, or attached to some additional dispensing apparatus, such as a pump, if the medication needs to be injected into the patient's body. It is appreciated that the step of triggering the membranes 40, 43, 46 may be accomplished through a wide range of means.
  • the triggering could be manually applied, such as by applying pressure to the triggers 33, 36, 39 in the case of a puncturing embodiment or applying a voltage thereto in the case of electrowetting membranes 40, 43, 46 or heating elements 41, 44, 47.
  • the membranes 40, 43, 46 may be automatically triggered, such as through use of an external timer or controlling mechanism.
  • the automatic triggering could be based on timing (i.e. set to trigger at specific times of the day) or may be adapted to trigger in response to detection of certain conditions (i.e. detection of blood sugar reaching a certain level). Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

L'invention concerne un système d'administration de médicament permettant de distribuer automatiquement une dose prédéfinie d'un agent thérapeutique ou d'un médicament. Le système d'administration de médicament comprend généralement un boîtier comprenant un ou plusieurs réservoirs ; chaque réservoir présentant un agent médical hermétiquement scellé en son sein. Une membrane s'étend à travers chacun du ou des réservoirs et est conçue pour permettre aux agents médicaux de passer à travers celle-ci en réponse à des stimuli externes, telles que la perforation physique, la fusion des membranes par l'utilisation d'éléments chauffants ou l'électro-mouillage en réponse à une impulsion de tension. Un matériau à effet de mèche s'étend à travers les membranes à travers lesquelles les agents médicaux sont distribués à un patient. Étant donné que le boîtier peut être rendu plat, le dispositif de distribution global peut être réduit en taille, permettant au dispositif d'administration de médicament d'être localisé et fixé au niveau de zones plus larges du corps du patient pour des applications médicales et un traitement étendus.
PCT/US2016/028058 2016-04-18 2016-04-18 Système d'administration de médicament WO2017184104A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/US2016/028058 WO2017184104A1 (fr) 2016-04-18 2016-04-18 Système d'administration de médicament

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2016/028058 WO2017184104A1 (fr) 2016-04-18 2016-04-18 Système d'administration de médicament

Publications (1)

Publication Number Publication Date
WO2017184104A1 true WO2017184104A1 (fr) 2017-10-26

Family

ID=60116232

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2016/028058 WO2017184104A1 (fr) 2016-04-18 2016-04-18 Système d'administration de médicament

Country Status (1)

Country Link
WO (1) WO2017184104A1 (fr)

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5232438A (en) * 1988-10-03 1993-08-03 Alza Corporation Membrane for electrotransport transdermal drug delivery
US5336213A (en) * 1992-04-08 1994-08-09 International Medical Associates, Inc. Selectable dosage transdermal delivery system
US6656147B1 (en) * 2000-07-17 2003-12-02 Becton, Dickinson And Company Method and delivery device for the transdermal administration of a substance
US6656162B2 (en) * 1999-11-17 2003-12-02 Microchips, Inc. Implantable drug delivery stents
US20070116752A1 (en) * 2004-06-05 2007-05-24 Dewan Fazlul Hoque Chowdhury Transdermal Drug Delivery Device Comprising Extensor-Relaxor Means
US7658728B2 (en) * 2006-01-10 2010-02-09 Yuzhakov Vadim V Microneedle array, patch, and applicator for transdermal drug delivery
US20140144179A1 (en) * 2010-06-22 2014-05-29 Marta Perez De La Iglesia Transdermal drug delivery bracelet
US9314571B1 (en) * 2012-02-10 2016-04-19 Mphase Technologies, Inc. Drug delivery system

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5232438A (en) * 1988-10-03 1993-08-03 Alza Corporation Membrane for electrotransport transdermal drug delivery
US5232438B1 (en) * 1988-10-03 2000-02-29 Alza Corp Transdermal electrotransport delivery of analgesic drugs
US5336213A (en) * 1992-04-08 1994-08-09 International Medical Associates, Inc. Selectable dosage transdermal delivery system
US6656162B2 (en) * 1999-11-17 2003-12-02 Microchips, Inc. Implantable drug delivery stents
US6656147B1 (en) * 2000-07-17 2003-12-02 Becton, Dickinson And Company Method and delivery device for the transdermal administration of a substance
US20070116752A1 (en) * 2004-06-05 2007-05-24 Dewan Fazlul Hoque Chowdhury Transdermal Drug Delivery Device Comprising Extensor-Relaxor Means
US7658728B2 (en) * 2006-01-10 2010-02-09 Yuzhakov Vadim V Microneedle array, patch, and applicator for transdermal drug delivery
US20140144179A1 (en) * 2010-06-22 2014-05-29 Marta Perez De La Iglesia Transdermal drug delivery bracelet
US9314571B1 (en) * 2012-02-10 2016-04-19 Mphase Technologies, Inc. Drug delivery system

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