WO2017134685A3 - Nouveaux composés hydrazino utilisés comme inhibiteurs de btk - Google Patents

Nouveaux composés hydrazino utilisés comme inhibiteurs de btk Download PDF

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Publication number
WO2017134685A3
WO2017134685A3 PCT/IN2017/050048 IN2017050048W WO2017134685A3 WO 2017134685 A3 WO2017134685 A3 WO 2017134685A3 IN 2017050048 W IN2017050048 W IN 2017050048W WO 2017134685 A3 WO2017134685 A3 WO 2017134685A3
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WO
WIPO (PCT)
Prior art keywords
novel
btk inhibitors
compounds
hydrazino compounds
hydrazino
Prior art date
Application number
PCT/IN2017/050048
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English (en)
Other versions
WO2017134685A2 (fr
Inventor
V.S.N. Murty KADIYALA
Virendra Narendra RAUT
Pratit SAVANT
Chetana Kaushal SHETH
Umesh Vishnu CHAUDHARI
Rajendrasinh Jashvantsinh RATHOD
Tushar Bhupendrabhai BHATT
Trinadha Rao Chitturi
Original Assignee
Sun Pharma Advanced Research Company Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sun Pharma Advanced Research Company Limited filed Critical Sun Pharma Advanced Research Company Limited
Publication of WO2017134685A2 publication Critical patent/WO2017134685A2/fr
Publication of WO2017134685A3 publication Critical patent/WO2017134685A3/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne de nouveaux composés hydrazino de Formule (I) utilisés comme inhibiteurs de tyrosine kinase de Bruton, leur procédé de préparation, et l'utilisation des composés dans la préparation de compositions pharmaceutiques pour le traitement thérapeutique de troubles impliquant une médiation de la tyrosine kinase de Bruton chez l'homme.
PCT/IN2017/050048 2016-02-02 2017-02-02 Nouveaux composés hydrazino utilisés comme inhibiteurs de btk WO2017134685A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN201621003737 2016-02-02
IN201621003737 2016-02-02

Publications (2)

Publication Number Publication Date
WO2017134685A2 WO2017134685A2 (fr) 2017-08-10
WO2017134685A3 true WO2017134685A3 (fr) 2018-06-28

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ID=59500779

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PCT/IN2017/050048 WO2017134685A2 (fr) 2016-02-02 2017-02-02 Nouveaux composés hydrazino utilisés comme inhibiteurs de btk

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WO (1) WO2017134685A2 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109111446B (zh) * 2017-06-22 2021-11-30 上海度德医药科技有限公司 一种具有药物活性的杂芳基化合物
CA3224945A1 (fr) 2018-07-31 2020-02-06 Loxo Oncology, Inc. Dispersions sechees par pulverisation, formulations et polymorphies de (s)-5-amino-3-(4-((5 fluoro-2-methoxybenzamido)methyl)phenyl)(1,1,1-trifluoropropan-2-yl)-1h-pyrazole-4-carboxamide
CN113544130B (zh) * 2019-05-31 2024-01-09 西藏海思科制药有限公司 一种btk抑制剂环衍生物及其制备方法和药学上的应用
CN111018865B (zh) * 2019-10-17 2021-01-15 山东大学 1-取代苄基吡唑并嘧啶衍生物及其制备方法与应用
CN116323594A (zh) * 2020-11-25 2023-06-23 四川海思科制药有限公司 一种btk降解剂的制备方法
TW202221002A (zh) * 2020-11-25 2022-06-01 大陸商四川海思科製藥有限公司 一種btk降解劑的製備方法
WO2023023537A1 (fr) * 2021-08-17 2023-02-23 Endotarget Inc. Composés et méthodes pour la dégradation ciblée de la tyrosine kinase de bruton

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008039218A2 (fr) * 2006-09-22 2008-04-03 Pharmacyclics, Inc. Inhibiteurs de la tyrosine kinase de bruton
WO2013177668A1 (fr) * 2012-05-31 2013-12-05 Pharmascience, Inc. Inhibiteurs de protéine kinases
WO2014005217A1 (fr) * 2012-07-06 2014-01-09 Pharmascience Inc. Inhibiteurs de protéines kinases

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008039218A2 (fr) * 2006-09-22 2008-04-03 Pharmacyclics, Inc. Inhibiteurs de la tyrosine kinase de bruton
WO2013177668A1 (fr) * 2012-05-31 2013-12-05 Pharmascience, Inc. Inhibiteurs de protéine kinases
WO2014005217A1 (fr) * 2012-07-06 2014-01-09 Pharmascience Inc. Inhibiteurs de protéines kinases

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