WO2017126949A1 - Appareil de formation de capsule de médicament capable d'effectuer une formation à vitesse élevée - Google Patents

Appareil de formation de capsule de médicament capable d'effectuer une formation à vitesse élevée Download PDF

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Publication number
WO2017126949A1
WO2017126949A1 PCT/KR2017/000785 KR2017000785W WO2017126949A1 WO 2017126949 A1 WO2017126949 A1 WO 2017126949A1 KR 2017000785 W KR2017000785 W KR 2017000785W WO 2017126949 A1 WO2017126949 A1 WO 2017126949A1
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Prior art keywords
chemical liquid
forming
nozzle
molding
capsule
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PCT/KR2017/000785
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English (en)
Korean (ko)
Inventor
최인규
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최인규
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Publication date
Priority claimed from KR1020160183956A external-priority patent/KR20170088283A/ko
Application filed by 최인규 filed Critical 최인규
Publication of WO2017126949A1 publication Critical patent/WO2017126949A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use

Definitions

  • the present invention relates to a medicine capsule molding apparatus, and more particularly to a medicine capsule molding apparatus that can maintain the sealing quality of the medicine capsule while implementing a high-speed molding of the medicine capsule.
  • Drug capsules are capsules containing liquid medicine therein. Drug capsules contain the drug in liquid form, so it is important to prevent the medicine inside from leaking to the outside.
  • FIG. 1 is a schematic diagram schematically showing the configuration of a conventional medicine capsule manufacturing apparatus 10 (20).
  • the medicine capsule C is formed between a pair of forming drums 11 and 11 'which rotate to face each other, called soft capsule mold dies.
  • the injection part 13 is disposed to simultaneously fill and cut the chemical liquid M, and joining and cutting are performed together.
  • FIG. 2 is a schematic diagram schematically showing a cross-sectional structure of a conventional chemical liquid injection unit 13.
  • the chemical liquid discharge holes (13b, 13c) is disposed at a position corresponding to the molding grooves (11b, 11b ') of the molding drum (11, 11'), conventional chemical liquid discharge
  • the balls 13b and 13c were located at a height within 10 mm from the lower end of the chemical injection portion 13. That is, in the conventional medicine capsule manufacturing apparatus, the height h2 of the first chemical liquid discharge hole 13c is positioned at a position lower than 10 mm.
  • the film (A, A ') used in the manufacture of the medicine capsule is provided by unfolding the gelatin in the form of a sheet, a molding drum after the chemical solution (M) is filled in the gelatin film (A, A') formed in the sheet form
  • the pair of molding drums 11 and 11' come into contact with each other to seal the gelatin films A and A ', thereby manufacturing a medicine capsule.
  • the gelatin films (A, A ') are temporarily stretched by the chemical solution, which is temporarily increased gelatin films (A, A ') ) Can be stable after the gelatin film (A, A ') is sealed only after the original state is restored.
  • a certain time is required for the gelatin film A and A, which has been temporarily stretched, to be restored to its original state. Accordingly, the forming drums 11 and 11 'of the conventional medicine capsule forming device 10 are therefore required.
  • the conventional capsule forming device 10 has a limitation of driving conditions in which the rotational speed of the forming drums 11 and 11 'must be maintained at 2.0 rpm / min.
  • the conventional medicine capsulation molding apparatus 10 shown in FIGS. 1 and 2 has a film A after the chemical liquid is discharged from the chemical liquid discharge holes 13b and 13c when the diameter of the molding drums 11 and 11 'is 150 mm. Sufficient sealing quality was maintained by a minimum of 0.58 seconds before, A ') was sealed. In order to satisfy the conditions of the sealing time, and to reduce the noise generated during the chemical injection, the conventional medicine capsule molding apparatus 10 maintains the rotational speed of the molding drum (11, 11 ') of Figure 1 at 2.0 rpm / min, There was a limitation of the driving conditions in which the height h2 of the first chemical liquid discharge hole 13c should be less than 10 mm.
  • the conventional medicine capsule forming apparatus 10 Due to the constraints of the driving conditions, the conventional medicine capsule forming apparatus 10 has a limitation in improving the manufacturing efficiency of the medicine capsule since the rotational speed of the molding drums 11 and 11 'is only 2.0 rpm / min.
  • An object of the present invention is to solve the above problems, to provide a medicine capsule molding apparatus that can improve the production efficiency by enabling high-speed molding of the medicine capsule while maintaining the sealing quality of the medicine capsule.
  • an object of the present invention is to provide a medicine capsule molding apparatus that can improve the production efficiency by enabling high-speed molding of the medicine capsule while maintaining a constant sealing quality and noise and vibration of the medicine capsule.
  • the medicine capsule molding device of the first embodiment of the present invention the capsule forming groove that rotates facing each other, corresponding to the shape of 1/2 of the capsule shape in the outside recessed a plurality of A pair of forming drums formed;
  • a chemical liquid injection unit disposed between the pair of molding drums, the plurality of nozzles supplying the chemical liquid to the capsule molding groove symmetrically to both sides about a center thereof;
  • a drum driving part for rotating the molding drum wherein the chemical liquid injection part corresponds to the circumferential shape of the molding drum with respect to the lower end part which is inserted and disposed to a sealing position where the capsule molding grooves of the pair of molding drums abut each other.
  • An injection part body having a contact curved surface, wherein a plurality of nozzles are disposed at different heights along the axial direction of the forming drum, and a first row nozzle positioned at a lower end of the contact curved surface is formed in the contact curved surface. It is characterized in that formed in the range of 12 ° ⁇ 70 ° along the curved surface of the contact surface from the center and the lower end of the drum.
  • the second row nozzle positioned above the first row nozzle is 17 ° to the curved surface of the contact surface from the center and the lower end of the forming drum. Characterized in that it is formed in the 70 ° range.
  • the third row nozzle located above the second row nozzle has 22 ° to 22 ° along the curved surface of the contact surface from the center and the lower end of the forming drum. Characterized in that it is formed in the 70 ° range.
  • the medicine capsule molding apparatus of the first embodiment of the present invention the chemical liquid injection portion, the chemical liquid inlet formed in the center of the upper surface of the injection portion main body in the form of a plurality of grooves along the axial direction of the molding drum; And a chemical liquid moving path connecting the chemical liquid inlet and the nozzle to each other to supply the chemical liquid to the nozzle.
  • the medicine capsule forming apparatus of the second embodiment of the present invention comprises: a pair of forming drums which rotate while facing each other, and formed with a plurality of recesses formed in a plurality of capsule forming grooves corresponding to one-half of the capsule shape; A chemical liquid injection part disposed on an upper portion of the pair of forming drums, the plurality of chemical liquid nozzles supplying the chemical liquid to the molding drum symmetrically formed at both lower sides thereof; And a drum driving part for rotating the molding drum, wherein the chemical liquid injection part is formed on the circumferential shape of the molding drum at the lower sides of both sides of the insertion end inserted into the region where the capsule molding grooves of the pair of molding drums are in contact with each other.
  • an injection part body having a corresponding film contact curved surface, wherein the chemical liquid nozzle is formed at an angle ranging from 12 ° to 175 ° from the center of the molding drum and the insertion end to the film contact curved surface.
  • the part is characterized in that the larger the angular range of the chemical liquid nozzle is formed to cover the area of the upper portion of the pair of forming drum.
  • the medicine capsule molding apparatus of the second embodiment of the present invention is characterized in that the width of the chemical liquid injection portion is formed larger than the diameter of the molding drum.
  • the medicine capsule molding apparatus of the second embodiment of the present invention is characterized in that the plurality of chemical liquid nozzles are arranged at the same height or at different heights on the film contact curved surface along the axial direction of the molding drum.
  • the medicine capsule molding device is characterized in that the plurality of chemical liquid nozzles are arranged in one or more rows along the curved surface of the film contacting curve from the insertion end.
  • the medicine liquid injection portion is formed on the upper surface of the injection portion main body side by side at the interval of arrangement of the capsule molding groove along the axial direction of the molding drum from the chemical liquid supply portion.
  • the medicine capsule molding apparatus of the first embodiment according to the present invention increases the driving speed of the molding drum by increasing the height and angle of the nozzle for injecting the chemical liquid, while at the same time enabling the high speed molding of the medicine capsule.
  • the sealing quality of the capsule can be maintained the same as the conventional.
  • the shape of the chemical liquid inlet of the chemical liquid inlet may be recessed to form a groove, thereby facilitating the processing of nozzles of various angles.
  • the medicine capsule molding apparatus of the second embodiment according to the present invention separates the angle of the nozzle for injecting the chemical liquid away from the sewing position, thereby improving the driving speed of the molding drum and maintaining the sealing quality of the medicine capsule. High speed molding of the capsule can be realized.
  • the thermal water of the chemical liquid nozzle can be adjusted in various ways.
  • the driving noise may be controlled by increasing the number of heat of the chemical liquid nozzle to reduce the number of times the chemical liquid supply unit is driven to supply the chemical liquid.
  • FIG. 1 is a schematic diagram schematically showing a medicine capsule molding process of a conventional medicine capsule molding apparatus
  • Figure 2 is a schematic diagram schematically showing the cross-sectional configuration of the chemical liquid injection portion of the conventional medicine capsule molding device
  • FIG. 3 is a schematic diagram schematically showing a medicine capsule molding process of the medicine capsule molding device according to the first embodiment of the present invention
  • Figure 4 is an exploded perspective view showing an exploded configuration of the drug capsule forming apparatus according to the first embodiment of the present invention
  • FIG. 5 is a cross-sectional view showing an example of the height and angle of the nozzle of the chemical liquid injection unit of the medicine capsule molding device according to the first embodiment of the present invention
  • FIG. 6 is a table for calculating the nozzle angle required for sealing and the speed of the forming drum when the conditions for forming the medicine capsule according to the first embodiment of the present invention are modified.
  • Figure 7 is a schematic diagram schematically showing a medicine capsule molding process of the conventional medicine capsule molding device
  • Figure 8 is a schematic diagram schematically showing the cross-sectional configuration of the chemical liquid injection portion of the conventional medicine capsule molding device
  • FIG. 9 is a schematic diagram schematically showing a medicine capsule forming process of a medicine capsule forming device according to a second embodiment of the present invention.
  • FIG. 10 is an exploded perspective view showing an exploded configuration of a medicine capsule molding apparatus according to a second embodiment of the present invention.
  • 11 to 13 are exemplary views showing modifications of the chemical liquid injection unit of the medicine capsule molding apparatus according to the second embodiment of the present invention.
  • FIG. 14 is an exemplary view showing another example of the chemical liquid injection unit of the medicine capsule molding device according to the second embodiment of the present invention.
  • FIG. 15 is a graph showing the nozzle angle and the speed of the forming drum required when the shape of the chemical liquid injection unit of the medicine capsule forming apparatus according to the second embodiment of the present invention is variously changed.
  • Figure 3 is a schematic diagram showing the configuration of the medicine capsule molding device 100 according to the first embodiment of the present invention
  • Figure 4 is an exploded perspective view showing an exploded configuration of the medicine capsule molding device 100
  • Figure 5 Is a cross-sectional view showing an example of the height and angle of the nozzle 123 of the chemical liquid injection unit 120.
  • the medicine capsule molding apparatus 100 is provided between a pair of molding drums 110 and 110 'that face each other and rotates, and a pair of molding drums 110 and 110'.
  • the pair of forming drums 110, 110 ' is rotated in a direction facing each other in the state that the film (A, A') is attached to the surface.
  • the film supply unit (not shown) supplies the pair of films A and A 'to the outer circumferential surface of the pair of forming drums 110 and 110', respectively.
  • a plurality of capsule-forming grooves 111 are recessed on the surfaces of the pair of forming drums 110 and 110 ′ as shown in FIGS. 3 and 4.
  • the capsule forming groove 111 is connected to the vent pipe 113, the vent pipe 113 is connected to the internal space.
  • the vent pipe 113 is formed to have a cavity corresponding to 1/2 of the shape of the medicine capsule C that is generated.
  • the capsule molding groove 111b is formed in the capsule forming groove 111 in communication with the inside of the tube forming hole 111, the cutting protrusion 111a is formed on the edge of the capsule forming groove 111 sharply.
  • the pair of forming drums (110, 110 ') are engaged with each other while the cutting protrusion (111a) is in contact with each other to cut the film (A, A') in the form of a capsule (C).
  • the chemical liquid injection unit 120 is disposed between the pair of molding drums 110 and 110 'and supplies the chemical liquid M to the capsule molding groove 111 of the rotating molding drums 110 and 110'.
  • the chemical liquid injection unit 120 according to the present invention by adjusting the position of the plurality of nozzles 123 for supplying the chemical liquid (M) to the forming drum (110,110 ') and the rotational speed of the forming drum (110,110') sealing quality.
  • the chemical liquid injection unit 120 is provided on the injection unit main body 121, the injection unit main body 121, and the chemical liquid injection hole 122 supplying the chemical liquid M to the injection unit main body 121, and the injection unit. It is provided on both lower surfaces of the main body 121 includes a plurality of nozzles 123 for injecting the chemical liquid into the capsule molding groove (111).
  • the injection unit body 121 of the chemical injection unit 120 is formed on both sides of the injection drum main body 121 with the capsule molding grooves 111 of the pair of molding drums 110 and 110 ′ inserted into and contacted with each other. It has a contact curved surface 121b corresponding to the circumferential shape of 110 and 110 '.
  • a plurality of nozzles 123 are formed on the contact curved surface 121b at intervals corresponding to the arrangement interval of the capsule forming grooves 111 along the axial direction of the forming drums 110 and 110 '.
  • the plurality of nozzles 123 may be disposed along the axial direction of the forming drums 110 and 110 ′ and may be disposed at different heights. When a plurality of nozzles are arranged at different heights, nozzles of different heights may be arranged in two or more rows, and may be arranged in three rows, four rows, and five rows.
  • the chemical liquid inlet 122 is formed in plural in the shape of a groove having a predetermined depth in the center of the upper surface of the injection unit body 121 to supply the same amount of the chemical liquid M to the plurality of nozzles 123.
  • the chemical liquid inlet 122 and the plurality of nozzles 123 are each connected by a plurality of chemical liquid movement paths 124 to receive the chemical liquid.
  • the chemical liquid inlet 122 may be formed in the shape of a groove recessed along the axial direction of the forming drum 110, 110 ′ at the center of the upper surface of the injection unit body 121 as shown in FIG. 4. It may be formed in the same quantity. At this time, the chemical liquid inlet 122 is formed in the shape of a groove, such as a square, semi-circle, ellipse cross section. The cross-sectional shape of the chemical liquid inlet 122 is formed in a groove shape so that the chemical liquid path 124 and the nozzle 123 may be formed at any angle with the contact curved surface 121b formed on both sides from the lower end 121a of the injection unit body 121. ) Is to facilitate the formation. That is, the nozzle 123 is formed at various angles, and the chemical liquid inlet 122 is formed in a groove shape in order to easily form the chemical liquid moving path 124 for connecting the nozzle 123 and the chemical liquid inlet 122. .
  • the plurality of nozzles 123 are positioned at both contact curved surfaces 121b of the injection unit body 121 to inject a chemical solution into the capsule molding groove 111.
  • the plurality of nozzles 123 are formed of the forming drums 110 and 110.
  • the center and the lower end portion 121a of the injection unit body 121 may be formed in an angle range of 10 ° to 70 °, preferably 30 ° to 70 ° along the curved surface of the contact curved surface 121b.
  • the first nozzle 123 is preferably located at the lowermost end of the contact curved surface 121b.
  • the column nozzle 123a is formed in a range of 12 ° to 70 °, more preferably 30 ° to 70 ° along the curved surface of the contact curved surface 121b from the center and the lower end 121a of the forming drums 110 and 110 '.
  • the second row nozzle 123b disposed above the first row nozzle 123a may be 17 ° to 70 ° along the curved surface of the contact curved surface 121b from the center and the lower end 121a of the forming drums 110 and 110 '. More preferably, it is preferably formed in the range of 35 ° to 70 °, and the third row nozzles (not shown) positioned above the second row nozzles 123b may have centers and lower ends of the forming drums 110 and 110 '. It is good to form in the range of 22 degrees-70 degrees, More preferably, 40 degrees-70 degrees along the curved surface of the contact curved surface 121b from 121a.
  • the first row nozzle 123a may be formed at a position of 30 ° along the curved surface of the contact curved surface 121b from the center and the lower end 121a of the forming drums 110 and 110 '
  • the second row nozzle. 123b may be formed at a position of 35 ° along the curved surface of the contact curved surface 121b from the center and the lower end 121a of the forming drums 110 and 110 '.
  • the height and angle of the nozzle 123 for the high-speed molding of the medicine capsule molding apparatus 100 of the present invention and the conventional injection drum (11, 11 ') shown in Figs. It may be calculated based on the driving conditions of the unit 13. That is, the height and angle of the nozzle 123 and the rotational speed (V2) of the forming drum (110,110 ') according to the present invention is a film (A) in the conventional molding drum (11, 11') and the chemical injection portion 13 , A ') may be calculated based on the travel time until the film A, A' is sealed.
  • the moving time until the sealing of the films A and A' is made as a basic time.
  • the forming drum (110,110 ') at a high speed for the same basic time to calculate the angle and height of the nozzle 123 that can prevent the leakage of the chemical liquid to set the driving conditions of the high-speed molding. That is, in the related art, after injection of the chemical liquid from the low-drug chemical discharge holes 13b and 13c, the molding drums 11 and 11 'move slowly to seal the films A and A', and thus, the medicine capsule of the present invention.
  • the molding apparatus 100 may seal the films A and A 'by rapidly moving the forming drums 110 and 110' after injecting the chemical liquid from a nozzle having a high height.
  • the rotational speed of the forming drum (110, 110 ') is different, but the time from injection of the chemical to the suture is set equal to the base time, the leakage of the chemical can be maintained the same.
  • the driving conditions of the conventional medicine capsule molding apparatus 10 having the same diameter are determined. Review first.
  • the diameters of the conventional molding drums 11 and 11 'are 150 mm, and the circumferential length of the molding drums 11 and 11' is 471 mm ( 150 mm x 3.14).
  • the circumferential movement distance per second of the forming drums 11 and 11 ' is circumferential length x rotational speed ⁇ 60, and the value accordingly is 15.7.
  • mm / sec (471 x 2.0 ⁇ 60).
  • the movement time (base time) from the nozzle 13c to the sealing point is obtained by dividing the height of the nozzle by the circumferential movement distance per second, which is 0.637 sec (10 ⁇ 15.7). Based on this, the basic time from filling the chemical liquid in the nozzle 13c to sealing the films A and A 'is set to 0.637 seconds.
  • the nozzle height required to increase the rotational speed of the forming drums 110 and 110 'from the nozzle 123 to the suture point in the medicine capsule forming apparatus 100 of the present invention based on the above-described basic time is 1.5 times higher than the conventional nozzle height. 15 mm (10 ⁇ 1.5) multiplied by 1.5, the nozzle height required to increase the rotational speed of the forming drums 110, 110 'by 1.7 times is 17 mm (10 mm ⁇ 1.7).
  • the circumferential length at an angle of 1 ° is a value obtained by dividing the entire circumferential length by 360. Accordingly, the circumferential length at an angle of 1 ° is 1.3083 mm (471 ⁇ 360).
  • the nozzle 123 may be formed at a position 13 ° along the curved surface of the contact surface 121b from the lower end 121a of the injection unit body 121 at the center C1 of the forming drums 110 and 110 '.
  • the nozzle 123 may be formed at a position of an angle of 30 ° along the curved surface of the contact surface 121b from the lower end 121a of the injection unit body 121 at the center C1 of the forming drums 110 and 110 '.
  • the nozzle 123 may be formed at a position of an angle of 45 ° along the curved surface of the contact surface 121b from the lower end 121a of the injection unit body 121 at the center C1 of the forming drums 110 and 110 '.
  • the nozzle 123 may be formed at a position of 52.5 ° along the curved surface of the contact surface 121b from the lower end 121a of the injection unit body 121 at the center C1 of the forming drums 110 and 110 '.
  • the nozzle 123 may be formed at a position 60 ° along the curved surface of the contact curved surface 121b from the lower end 121a of the injection unit body 121 at the center C1 of the forming drums 110 and 110 '.
  • the nozzle 123 ' may be formed at an angle of 7.71 ° similarly to the conventional chemical liquid discharge hole 13c.
  • the theoretically formed nozzle 123 at an angle of 13 ° may be sealed of the capsule while achieving a speed increase of 1.7 times or more, and a nozzle formed at an angle of 30 ° ( 123 may be implemented to increase the speed more than three times compared to the conventional, the nozzle 123 formed at a position of 45 ° angle is possible to increase the speed more than five times compared to the conventional, the nozzle 123 formed at a position of 52.5 ° angle is It is possible to increase the speed by more than 6 times compared to the conventional, and the nozzle 123 formed at a position of an angle of 60 ° can be increased by more than 7 times compared to the conventional.
  • the drum driving unit 130 may drive the rotational speed of the forming drums 110 and 110 'faster as the angle range in which the nozzle 123 is formed from the center of the forming drums 110 and 110' becomes larger.
  • the angle of the nozzle 123 for the high-speed molding of the medicine capsule is a conventional height of 10mm, the angle is 7.645 °, compared with the conditions that rotated at 2 rpm / min, the nozzle angle is 10 ° ⁇ 70 °, preferably It is preferable to set in the range of 30 degrees-70 degrees. If the nozzle angle is lower than 10 °, the difference between the rotational speed of the conventional molding drum is insignificant, and if the nozzle angle exceeds 70 °, the leakage of chemical liquid is generated due to the vibration generated by the rotation of the molding drum. Problems of deterioration of quality may occur.
  • the chemical liquid injection unit 120 includes a plurality of nozzles having one height in a row along the axial direction of the forming drums 110 and 110 ', or two nozzles having different heights as shown in FIG. It is provided side by side and at the same time to inject the chemical liquid into the capsule forming grooves 111 of different positions, and may also be provided in three rows, four rows, five rows of nozzles having different heights. According to the present invention, as the rotational speeds of the forming drums 110 and 110 'are increased, the injection speeds of the chemical liquids which simultaneously inject the chemical liquid into the capsule forming grooves 111 at different positions are different from each other. It is preferable.
  • the first row nozzles 123a positioned at the lowermost ends of the contact curved surface 121b.
  • the second row nozzle 123b positioned above the row nozzle 123a is in the range of 17 ° to 70 ° along the curved surface of the contact curved surface 121b from the center and the lower end 121a of the forming drums 110 and 110 '.
  • the third row nozzle 123c positioned above the second row nozzle 123b has a contact curved surface from the center and the lower end 121a of the forming drums 110 and 110 '. It is good to form in the range of 22 degrees-70 degrees, Preferably it is 40 degrees-70 degrees along the curved surface of 121b.
  • the height of the first row nozzle 123a, the second row nozzle 123b, and the third row nozzle is set in consideration of the difference by the position of the capsule molding groove 111, and preferably, the average It is better to arrange with a difference of about 5 °.
  • the height of the nozzle 123 and the nozzle angle ⁇ may be adjusted differently according to the diameters of the forming drums 110 and 110 ′.
  • the chemical liquid is supplied to the chemical liquid injection part 120 and discharged to the nozzles 123a and 123b.
  • the nozzles 123a and 123b have a first angle having a angle of 12 to 70 ° from the center C1 of the forming drums 110 and 110 'and the lower end 121a of the injection part body 121.
  • Height and a second height having an angle of 17 to 70 ° from the center C1 of the forming drums 110 and 110 'and the lower end 121a of the injection unit body 121.
  • the second height may vary depending on the shape of the capsule, and is disposed in consideration of the position, that is, the number and size of the capsule forming grooves 111 in the rotational direction of the forming drums 110 and 110 ', preferably about 5 ° on average. It is better to be placed with a difference of.
  • the drum driving unit 130 is a capsule forming groove 111 of the pair of forming drums (110, 110 ') are in contact with each other after the chemical liquid (M) is injected from the first row nozzle (123a) and the second row nozzle (123b) Adjust the driving speed (V2) of the forming drum (110,110 ') to move to the sewing position in the base time.
  • the drum drive unit 130 has an angle range in which the nozzles 123a and 123b are formed along the curved surface of the contact surface 121b from the center of the forming drums 110 and 110 'and the lower end 121a of the injection unit body 121. As it increases, the rotation speed of the forming drums 110 and 110 'may be driven faster.
  • the cutting protrusions 111a of the pair of capsule forming grooves 111 are engaged with each other, and the pair of films A and A 'are cut, and the capsule is molded to form the pair of forming drums 110 and 110'. Falls to the bottom.
  • the driving speeds V2 of the forming drums 110 and 110 ′ are about 8 rpm / min and 15 rpm / min, respectively. Can be adjusted.
  • the second row nozzle 123b may also increase the chemical injection speed by injecting the chemical solution into the capsule forming groove 111 having the corresponding height.
  • the driving speeds V2 of the forming drums 110 and 110 'are 8 rpm / min and 15 rpm / min the driving speeds are approximately 4 times and 7.5 times faster, respectively, than those of the conventional nozzle angles of 7.645 ° and 2 rpm / min.
  • the sealing quality of the medicine capsule can be kept the same as before. Accordingly, the manufacturing efficiency of the medicine capsules C formed in the same forming drum 110 and 110 ′ may be approximately 4 times and 7.5 times faster while maintaining the sealing quality.
  • the medicine capsule molding apparatus increases the driving speed of the molding drum by increasing the height and the angle of the nozzle for injecting the chemical liquid, thereby enabling high-speed molding of the medicine capsule while simultaneously enabling the medicine capsule.
  • the sealing quality can be kept excellent.
  • the shape of the chemical liquid inlet of the chemical liquid inlet may be recessed to form a groove, thereby facilitating the processing of nozzles of various angles.
  • FIG. 9 is a schematic view showing the configuration of the medicine capsule molding apparatus 200 according to the second embodiment of the present invention
  • FIG. 10 is an exploded perspective view showing an exploded configuration of the medicine capsule molding apparatus 200
  • FIG. 11 Is a view showing the configuration of the chemical injection unit 220.
  • the medicine capsule molding apparatus 200 is provided with a pair of molding drums 210 and 210 'which are rotated facing each other and a pair of molding drums 210 and 210'.
  • the chemical liquid injection unit 220 for supplying the chemical liquid M to the molding drums 210 and 210 ', the drum driving unit 230 for driving the molding drums 210 and 210', and a pair of films A and A ' And a film supply unit (not shown) for supplying the pair of forming drums 210 and 210 'and a chemical solution supply unit 240 for supplying the chemical liquid M to the chemical liquid injection unit 220.
  • the pair of forming drums 210 and 210 ' is rotated in a direction facing each other with the films A and A' attached to the surface thereof.
  • the film supply unit (not shown) supplies the pair of films A and A 'to the outer circumferential surface of the pair of forming drums 210 and 210', respectively.
  • a plurality of capsule-forming grooves 211 are recessed as shown in FIG.
  • the capsule forming groove 211 is connected to the vent pipe 214, the vent pipe 214 is connected to the internal space.
  • the capsule shaping groove 211 is formed to have a space corresponding to half of the shape of the medicine capsule C to be generated.
  • the capsule molding hole 212 is formed in the interior of the capsule forming groove 211 is in communication with the tube 214, the cutting protrusion 213 is provided on the edge of the capsule forming groove 211 is sharply formed.
  • the chemical liquid injection unit 220 is disposed on the pair of molding drums 210 and 210 'to supply the chemical liquid M to the capsule forming grooves 211 of the rotating molding drums 210 and 210'.
  • the chemical liquid injection unit 220 according to the present invention is closed by controlling the position of the plurality of chemical liquid nozzles 227 for supplying the chemical liquid (M) to the forming drums 210 and 210 'and the rotational speed of the forming drums 210 and 210'. High speed molding is achieved while maintaining quality.
  • the chemical liquid injection unit 220 includes an injection unit body 221, an insertion end 222 inserted between a pair of molding drums 210 and 210 ′ in a lower center area of the injection unit body 221, and an injection unit body 221. Injected to the upper portion of the chemical liquid injection path 223 and the chemical liquid injection path 223 to form a moving path of the chemical liquid (M) supplied from the chemical liquid supply unit 240, the injection liquid main body Injecting the chemical liquid vertical movement path 225 to move to the lower portion of the 221, and the chemical liquid (M) moved to the lower portion of the chemical liquid vertical movement path 225 into the capsule molding groove 211 of the molding drum (210, 210 ').
  • the chemical liquid nozzle 227 is included.
  • the injection part main body 221 is formed in the upper surface is flat, the lower portion is formed recessed to correspond to the circumferential surface of the forming drum (210, 210 ') symmetrically around the insertion end 222, forming drum (210, 210') and the drum It includes a film contact surface 226 is in contact with the film.
  • a plurality of chemical liquid nozzles 227 are disposed on the film contact curved surface 226.
  • the plurality of chemical liquid nozzles 227 are formed on the film contact curved surface 226 at intervals corresponding to the arrangement intervals of the capsule forming grooves 211 along the axial direction of the forming drums 210 and 210 '.
  • the plurality of chemical liquid nozzles 227 may be arranged in one row or at different heights on the film contact curved surface 226 along the axial direction of the forming drums 210 and 210 ', and may be arranged in different heights.
  • the chemical nozzles 227 of different heights may be arranged in two or more rows, and three, four, five, six, seven, eight, nine, etc. It may be arranged together, and may be arranged in more than 10 rows. Preferably, it is preferably arranged in two rows, four rows, six rows, eight rows, and the like.
  • the plurality of chemical liquid nozzles 227 are formed to be spaced apart from the lower end of the insertion end 222 by the nozzle angle ⁇ along the curved surface of the film contacting surface 226.
  • the nozzle angle ⁇ is formed in the range of 12 ° to 175 °.
  • the nozzle angle ⁇ of the chemical liquid nozzle 227 for high-speed molding of the medicine capsule molding apparatus 200 of the present invention is a conventional forming drum (21, 21 ') shown in Figure 7 and 8 having the same diameter
  • the driving condition of the chemical liquid injection unit 23 is calculated. That is, the nozzle angle ⁇ of the chemical liquid nozzle 227 and the rotational speed V2 of the molding drums 210 and 210 'according to the present invention shown in FIG. 14 are conventional molding drums 21 and 21' and the chemical liquid injection unit ( In 23), the chemical liquid is calculated based on the movement time from filling the films A and A 'to sealing the films A and A'.
  • a nozzle 200 is formed by the chemical liquid nozzle 227 from a position where the films A and A 'are sealed, that is, a region where the pair of molding drums 210 and 210' contact each other (X in FIG. 9). Placed apart by as much as possible, a pair of forming drum (210, 210 ') at a high speed to seal the film (A, A').
  • the conventional molding drums 21 and 21 'of FIG. 7 and the present invention have different rotational speeds of the molding drums 210 and 210', but the time from injection of the chemical to the suture is set equal to the basic time, so that the medicine capsule C The sealing quality of can be maintained.
  • the driving conditions of the conventional medicine capsule molding apparatus 20 having the same diameter are determined. Review first.
  • the diameters of the conventional forming drums 21 and 21 ′ are 150 mm and the forming drums 21 are 21.
  • the driving speed V2 of the molding drums 210 and 210' is set.
  • FIG. 15 is a diagram showing a nozzle angle for increasing the rotational speed of the forming drums 210 and 210 'of the present invention based on the basic rotational speed 2 rpm shown in FIG.
  • the medicine capsule molding apparatus 200 changes the position of the chemical liquid nozzle 227 away from the closed position X to increase the driving speed of the molding drums 210 and 210 'by 10 times.
  • the chemical liquid nozzle 227 formed at an angle of 12 ° may seal the medicine capsule while increasing the speed by approximately 1.3 times or more, and the chemical liquid nozzle formed at the angle of 60 ° ( 227 may implement a speed increase of approximately 5 times in the prior art, and the chemical liquid nozzle 227 formed at a position of 100 ° may be 8 times faster than the conventional liquid chemical nozzle 227 formed at a position of 160 °.
  • the drum driving unit 230 may drive the rotational speed of the forming drums 210 and 210 'faster as the angular range in which the chemical liquid nozzle 227 is formed from the center of the forming drums 210 and 210' becomes larger.
  • the nozzle angle ⁇ of the chemical liquid nozzle 227 is preferably formed in the range of 12 ° to 175 °.
  • the chemical liquid injection unit 220 is provided with a plurality of chemical liquid nozzles in a row along the axial direction of the forming drum (210, 210 ') to one height, or nozzles having different heights are provided side by side in two rows
  • the chemical liquid can be injected into the capsule forming grooves 211 at different positions, and nozzles having different heights are arranged in three rows, four rows, five rows, six rows, seven rows, eight rows, nine rows, and even ten. It may also be provided in rows or more.
  • the chemical nozzles of different heights can increase the injection speed of the chemical liquid to simultaneously inject the chemical liquid into the capsule forming grooves 211 at different positions.
  • the film contact curved surfaces 226 at the insertion end 222 are located in the range of 12 ° to 175 °, preferably in the range of 30 ° to 175 ° along the curved surface of the film contacting surface 226 from the center of the forming drums 210 and 210 'and the insertion end 222.
  • the second nozzle located above the first nozzle is preferably in the range of 17 ° to 175 ° along the curved surface of the film contact surface 226 from the center of the forming drums 210 and 210 'and the insertion end 222. Is preferably formed in the range of 35 ° to 175 °, and the third nozzle located at the top of the second nozzle has a curved surface of the film contact surface 226 from the center of the forming drums 210 and 210 'and the insertion end 222. Therefore, it is preferably formed in the range of 22 ° to 175 °, preferably in the range of 40 ° to 175 °. At this time, the height of the first nozzle, the second nozzle, the third nozzle, etc.
  • the height is preferably set to a difference of about 5 ° on average It is good. Meanwhile, the height of the nozzle 127 and the nozzle angle ⁇ may be adjusted differently according to the diameters of the forming drums 210 and 210 '.
  • a medicine capsule molding apparatus 200 is that the nozzle angle ( ⁇ ) is set to 170 °, referring to Figure 15, the conventional medicine capsule molding of Figure 7
  • the forming drums 210, 210 ′ can be driven 13 times or more faster than the device 20.
  • the width W2 from the center of the chemical injection portion 220 to both sides increases.
  • the width W1 of the chemical liquid injection unit 23 does not need to be wide.
  • the chemical liquid injection unit 220 according to the preferred embodiment of the present invention has to be located at the nozzle angle of 170 °, the chemical liquid nozzle 227 is disposed, and the injection unit main body 221 has a pair of molding drums ( 210, 210 ') to cover the entire upper portion.
  • the width (2 ⁇ W2) of the chemical liquid injection unit 220 may be formed larger as the nozzle angle ( ⁇ ) is larger, preferably the width (2 ⁇ W2) of the chemical liquid injection unit 220 is It can be formed larger than the diameter of the forming drum.
  • FIG. 11 is a view showing the configuration of a chemical injection unit 220 according to a preferred embodiment of the present invention.
  • FIG. 11 is a view illustrating a case in which one row of chemical liquid nozzles 227 are disposed on both sides of the chemical liquid injection unit 220.
  • a plurality of chemical injection paths 223 are formed along the axial direction of the forming drums 210 and 210 ′ on the upper surface of the chemical injection unit 220.
  • the chemical liquid injection path 223 guides the chemical liquid M supplied from the chemical liquid supply part 240 to the chemical liquid vertical movement path 225.
  • the chemical liquid M moved along the chemical liquid vertical movement path 225 is discharged into the capsule molding groove 211 through the chemical liquid nozzle 227.
  • the chemical liquid nozzles 227 are arranged in one row on the film contact curved surface 226 as shown in FIG.
  • the chemical liquid nozzles 227 arranged in one row alternately inject the chemical liquid M into the capsule molding groove 211a of the preceding row and the capsule molding groove 211b of the rear row.
  • FIG. 12 is a view showing the shape of the chemical liquid injection part 220a when the chemical liquid nozzles 227 are arranged in four rows from side to side.
  • a pair of chemical injection paths 223a are disposed on the upper surface of the injection unit body 221a of the chemical injection unit 220a, and a pair of chemical injection paths 223a are fixed.
  • the interval d1 is disposed to be spaced apart.
  • the separation interval of the chemical injection path 223a corresponds to the interval d1 between the adjacent chemical liquid nozzles 227 as shown in FIG.
  • a pair of chemical liquid injection passages 223a are respectively formed with a pair of chemical liquid vertical movement passages 225a, and four chemical liquid nozzles 227a, 227b, 227c, and 227d are coupled to the chemical liquid vertical movement passages 225a.
  • the chemical liquid nozzle 227a of the first row injects the chemical liquid M into the capsule molding groove 211a of the first row, and the chemical liquid nozzle 227b of the second row of the chemical liquid M into the capsule molding groove 211b of the second row.
  • the chemical liquid nozzle 227c in the third row is injected into the capsule molding groove 211c in the third row, and the chemical liquid nozzle 227d in the fourth row is injected into the capsule molding groove 211d in the fourth row.
  • the four rows of chemical nozzles 227a, 227b, 227c, and 227d simultaneously spray the chemical liquid into the four rows of capsule molding grooves 211a, 211b, 211c, and 211d, and then rotate to the next capsule molding groove by rotation of the molding drums 210 and 210 '. Spray the chemical solution.
  • the number of driving of the cam and the piston to drive the chemical liquid to the chemical liquid injecting path 223 is reduced to 1/4 when compared to when the chemical liquid is injected one row at a time.
  • FIG. 13 is a view showing the shape of the chemical liquid injection part 220b when the chemical liquid nozzles 227 are arranged in eight rows from side to side.
  • a set of four chemical injection holes 223b is formed in the upper portion of the injection part body 221b of the chemical injection portion 220b.
  • a chemical liquid vertical movement path 225b is formed at an end of each chemical liquid injection path 223b.
  • the four chemical liquid vertical movement paths 225b are spaced apart from each other in the horizontal direction by a predetermined distance d2 and d3, and are spaced vertically apart by a predetermined height L so that no interference occurs in the injection of the chemical liquid. .
  • the end portion of the chemical liquid vertical movement path 225b is connected to two rows of chemical liquid nozzles as shown in FIG.
  • eight chemical liquid nozzles 227a, 227b, 227c, 227d, 227e, 227f, 227g, and 227h are formed in the four chemical liquid vertical movement paths 225b.
  • a total of eight rows of chemical nozzles (227a, 227b, 227c, 227d, 227e, 227f, 227g, 227h) are formed on the film contact curved surface 226b as shown in FIG. 211a, 211b, 211c, 211d, 211e, 211f, 211g, 211h).
  • the number of driving cycles of the cam and the piston for driving the chemical liquid to the chemical liquid injection path 223 is reduced to 1/8 as compared with the case of spraying the chemical liquid by one row.
  • the driving speed of the molding drums 210 and 210 ' is increased by changing the position of the chemical liquid nozzle 227.
  • the noise and vibration of the cam and the piston are increased by the driving of the chemical liquid supply unit, while the chemical liquid nozzles 227 are formed in two rows, three rows, four rows, five rows, six rows, seven rows, and eight rows. Since the number of driving of the cam and piston is reduced compared with the conventional first row, the total driving noise is the same as that of the conventional 2 rpm.
  • the noise generated when rotating 6 by 1 column charge is 12 turns by 2 heat charges, when rotates 24 by 4 heat charges, and rotates 36 by 6 heat charges. In this case, it may be the same as the case of 48 revolutions with 8 thermal charges.
  • the nozzle angle should be adjusted to 34.18 °. At this time, considering the driving noise, it is possible to calculate the number of heat of the chemical liquid nozzle 227 optimized for the increase drainage.
  • the number of the chemical liquid nozzles 227 according to an increase and multiple of the driving speed may vary.
  • a pair of molding drums 210 and 210 ' are provided to rotate to face each other, and a chemical injection portion 220 is disposed on the pair of molding drums 210 and 210'.
  • the chemical injection portion 220 is formed to cover all of the upper portion of the pair of forming drums (210, 210 '), the chemical nozzles (227,227a) along the curved surface of the contact surface around the insertion end of the nozzle angle ( ⁇ ) It is formed in one row at 170 °.
  • the chemical liquid supply unit 240 supplies the chemical liquid M to the chemical liquid injection path 223, the chemical liquid M is moved to the chemical liquid nozzle 227 through the chemical liquid vertical movement path 225.
  • the chemical liquid nozzle 227 injects the chemical liquid M into the capsule molding groove 211 as shown in FIG. 11C.
  • the drum driving unit 230 is a chemical liquid (M) is injected from the chemical liquid nozzle 227 in a basic time until the sealing position (X) in which the capsule forming grooves 211 of the pair of molding drums 210 and 210 'contact each other.
  • the driving speed V2 of the forming drums 210 and 210 ' is adjusted to be moved.
  • the driving speed V2 of the forming drums 210 and 210 ′ may be adjusted to about 26 rpm / min.
  • the sealing speed of the capsule is about the same as that of the conventional nozzle angle of 7.645 ° and 2 rpm / min, although the driving speed is 13 times faster. Can be maintained. Accordingly, the manufacturing efficiency of the medicine capsules C formed in the same forming drums 210 and 210 'may be 13 times faster while maintaining the same sealing quality.
  • the medicine capsule molding apparatus separates the angle of the nozzle for injecting the chemical liquid away from the sewing position, thereby improving the driving speed of the molding drum and maintaining the sealing quality of the medicine capsule while maintaining the quality of the medicine capsule.
  • High speed molding can be realized.
  • the thermal water of the chemical liquid nozzle can be adjusted in various ways.
  • the driving noise may be controlled by increasing the number of heat of the chemical liquid nozzle to reduce the number of times the chemical liquid supply unit is driven to supply the chemical liquid.

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

La présente invention concerne un appareil de formation de capsule de médicament comprenant : une paire de cylindres de formation tournant en se faisant mutuellement face, ayant chacun une pluralité d'évidements de formation de capsule formés de façon concave sur l'extérieur de ceux-ci, les évidements de formation de capsule ayant une forme correspondant à la moitié d'une capsule de médicament; une partie d'injection de médicament disposée entre la paire de cylindres de formation et comportant une pluralité de buses pour distribuer un médicament dans les évidements de formation de capsule, les buses étant formées sur des côtés opposés de la partie d'injection de médicament de manière à présenter une symétrie bilatérale par rapport au centre de la partie d'injection de médicament; et une partie d'entraînement de cylindre pour faire tourner les cylindres de formation, la partie d'injection de médicament comprenant un corps principal de partie d'injection de surface de contact incurvé sur les côtés opposés d'une partie d'extrémité inférieure de celui-ci qui est inséré à une position d'encapsulation où les évidements de formation de capsule de la paire de cylindres de formation viennent en contact les uns avec les autres, les surfaces de contact incurvées correspondant aux surfaces circonférentielles externes des cylindres de formation, et une pluralité de buses sont agencées à différentes hauteurs sur les surfaces de contact incurvées dans la direction axiale des cylindres de formation, les buses dans la première rangée située à la position la plus basse de chaque surface de contact incurvée étant formées le long de la surface de contact incurvée dans la plage de 12° à 70° par rapport au centre du cylindre de formation correspondant et la partie d'extrémité inférieure du corps principal de partie d'injection.
PCT/KR2017/000785 2016-01-22 2017-01-23 Appareil de formation de capsule de médicament capable d'effectuer une formation à vitesse élevée WO2017126949A1 (fr)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
KR20160008196 2016-01-22
KR10-2016-0008196 2016-01-22
KR10-2016-0105211 2016-08-19
KR20160105211 2016-08-19
KR10-2016-0183956 2016-12-30
KR1020160183956A KR20170088283A (ko) 2016-01-22 2016-12-30 고속성형이 가능한 약 캡슐 성형장치
KR20170010346 2017-01-23
KR10-2017-0010346 2017-01-23

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107638297A (zh) * 2017-11-21 2018-01-30 孟瑶 一种中药混合药丸成型装置

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11221267A (ja) * 1998-02-09 1999-08-17 Kamata:Kk ソフトカプセル製造装置及びその製造方法
JP2001017514A (ja) * 1999-07-02 2001-01-23 Sankyo:Kk ゼラチンカプセルの製造方法並びにその製造装置
JP2003040768A (ja) * 2001-07-31 2003-02-13 Sankyo:Kk ゼラチンカプセル並びにその製造方法並びにその製造装置
JP4380784B2 (ja) * 2006-11-15 2009-12-09 新東工業株式会社 タブレット成型方法およびそのロール圧縮式成型機
KR100979586B1 (ko) * 2005-11-18 2010-09-01 가부시키가이샤 가마타 소프트 캡슐 제조 장치

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11221267A (ja) * 1998-02-09 1999-08-17 Kamata:Kk ソフトカプセル製造装置及びその製造方法
JP2001017514A (ja) * 1999-07-02 2001-01-23 Sankyo:Kk ゼラチンカプセルの製造方法並びにその製造装置
JP2003040768A (ja) * 2001-07-31 2003-02-13 Sankyo:Kk ゼラチンカプセル並びにその製造方法並びにその製造装置
KR100979586B1 (ko) * 2005-11-18 2010-09-01 가부시키가이샤 가마타 소프트 캡슐 제조 장치
JP4380784B2 (ja) * 2006-11-15 2009-12-09 新東工業株式会社 タブレット成型方法およびそのロール圧縮式成型機

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107638297A (zh) * 2017-11-21 2018-01-30 孟瑶 一种中药混合药丸成型装置
CN107638297B (zh) * 2017-11-21 2021-01-26 龙晖药业有限公司 一种中药混合药丸成型装置

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