WO2017109217A1 - Ligands macrocycliques avec groupement(s) picolinate(s), leurs complexes ainsi que leurs utilisations médicales - Google Patents
Ligands macrocycliques avec groupement(s) picolinate(s), leurs complexes ainsi que leurs utilisations médicales Download PDFInfo
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- 0 *c1cccc(C(O)=O)n1 Chemical compound *c1cccc(C(O)=O)n1 0.000 description 10
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
Definitions
- the present invention relates to novel macrocyclic ligands as well as their complexes, in particular radioactive complexes, and their uses in medical imaging and / or in therapy, particularly in interventional radiology.
- the present invention also relates to a new process for the preparation of ligands as in the invention, as well as their preparation intermediates.
- Interventional radiology is a very promising area of individualized medicine. It allows to combine in the same sequence an accurate diagnosis of the lesion or tumor and / or its instantaneous treatment, guided and controlled by the image. It is described as a minimally invasive surgery and can be performed as an outpatient, which saves many expensive days of hospitalization for efficiency often comparable to conventional surgery. Interventional radiology may therefore be an alternative or complement to conventional surgical treatment.
- Interventional radiology provides access to a lesion or tumor located within the body to perform a diagnostic procedure (eg, sampling) or a therapeutic procedure.
- Imaging by fluoroscopy, ultrasound, CT or MRI allows identification, guidance and optimal control of the medical procedure.
- Such ligands must in particular be stable and sufficiently complex the metals so that they reach their target and do not diffuse into other organs or sensitive tissues such as bones, lungs and kidneys.
- the present invention aims to provide new ligands for complexing chemical elements, in particular radioelements.
- the present invention also aims to provide new complexes, in particular radioactive complexes.
- the present invention aims to provide ligands and / or complexes particularly useful in medical imaging and / or therapy, particularly in the treatment of cancers.
- the present invention also aims to provide a pharmaceutical composition comprising complexes for medical imaging, targeting and / or treatment of cancers.
- the object of the present invention is to provide a new process for the preparation of these ligands.
- the present invention relates to a compound of general formula (I) below:
- R 1; R 2 , R 3 , R 4 , R 5 and R 6 represent independently of each other H, a (C 1 -C 20 ) alkyl group or a (C 1 -C 2 O) alkylene- (C 6 -C 10 ) aryl group; ; said alkyl, alkylene and aryl groups being optionally substituted by one or more substituents chosen from organic acid functional groups, preferably from the group consisting of -COOH, -SO 2 OH, -P (O) ( OH) 2 and -O-P (O) (OH) 2 ;
- X 2 and X 3 are independently selected from the group consisting of: H, -C (O) N (Re) (Rd), (C 1 -C 20 ) alkyl, (C 2 -C 20 ) alkenyl, (C 2 -C 20 ) alkynyl and (C 6 -C 10 ) aryl,
- Re and Rd being independently of one another H or a group (CC 20 ) alkyl
- said alkyl, alkenyl and alkynyl groups may optionally comprise one or more heteroatoms and / or one or more (C 6 -C 10 ) arylene (s) in their chain and may be optionally substituted with a (C 6 -C 10) aryl; said alkyl, alkenyl, alkynyl and aryl groups being optionally substituted by one or more substituents selected from organic acid functional groups, preferably from the group consisting of -COOH, -SO 2 OH, -P (0) ) (OH) 2, and - O-P (O) (OH) 2 ;
- Y 1 , Y 2 and Y 3 represent, independently of one another, a C (O) OH group or a group of formula II) that follows:
- radicals R 1 are chosen independently of each other from the group consisting of: H, halogen, N 3 , (C 1 -C 20 ) alkyl, (C 2 -C 20 ) alkenyl, (C 2 -C 20 ) alkynyl and (C 6 -C 10 ) aryl,
- alkyl, alkenyl and alkynyl groups which may optionally comprise one or more heteroatoms and / or one or more (C 6 -C 10 ) arylene (s) in their chain and which may be optionally substituted with a (C 6 -C 10) aryl;
- alkyl, alkenyl, alkynyl and aryl groups being optionally substituted by one or more substituents selected from organic acid functional groups, preferably from the group consisting of -COOH, -SO 2 OH, -P (0) ) (OH) 2, and - O-P (O) (OH) 2 ;
- radicals Y 1 , Y 2 and Y 3 being a group of formula (II);
- the present invention relates to a compound of general formula (I) below: in which :
- R 1, R 2 , R 3 , R 4 , R 5 and R 6 represent, independently of one another, H, a (C 1 -C 20 ) alkyl group or a (C 1 -C 2 O) alkylene (C 6) group; -Ci 0 ) aryl;
- X 1 , X 2 and X 3 are independently selected from the group consisting of: H, -C (O) N (Re) (Rd), (C 1 -C 20 ) alkyl, (C 2 -C 20) alkenyl, (C 2 -C 20 ) alkynyl and (C 6 -C 10 ) aryl,
- Re and Rd being independently of one another H or a group (CC 20 ) alkyl
- alkyl, alkenyl and alkynyl groups which may optionally comprise one or more heteroatoms and / or one or more (C 6 -C 10 ) arylene (s) in their chain and which may be optionally substituted by a (C 6 -C 10) aryl;
- Y 1; Y 2 and Y 3 represent, independently of one another, a C (O) OH group or a group of formula II) that follows:
- radicals R 1 are independently selected from the group consisting of: H, halogen, N 3 , (C 1 -C 20 ) alkyl, (C 2 -C 20 ) alkenyl, (C 2 -C 20 ) alkynyl and (C 6 -C 10 ) aryl,
- alkyl, alkenyl and alkynyl groups which may optionally comprise one or more heteroatoms and / or one or more (C 6 -C 10 ) arylene (s) in their chain and which may be optionally substituted with a (C 6 -C 10 ) aryl; and at least one of the radicals Y 1 , Y 2 and Y 3 being a group of formula (II);
- the inventors have developed new ligand-metal complexes (complexes also called chelates) from the macrocycle pyclene (3,6,9,15-tetraazabicyclo [9.3.1] pentadeca-1 (15), 1 1, 13- triene), variously substituted with acetate and / or picolinate groups (methylene-6-pyridine-2-carboxylic acid).
- the pyclene macrocycle is of the following formula:
- the complexes according to the invention have good thermodynamic stability as well as good kinetic inertia.
- the inventors have discovered that the complexes according to the invention can be solubilized in an iodized oil such as LIPIODOL ® , an iodized oil manufactured and marketed by Guerbet and which consists of ethyl esters. iodized fatty acids of the carnation oil.
- an iodinated oil such as LIPIODOL ® can be vectorized in particular to the liver and can be used to visualize and / or treating cancers, such as liver cancer.
- the vectorization of the complexes according to the invention with an iodinated oil such as LIPIODOL® makes it possible in particular to avoid poor delivery of the complexes by reducing the risk of adverse effects in healthy organs, in particular the healthy liver or in extra-normal organs. hepatic, and achieves the effective dose of radioactivity in the tumor. More particularly, this vectorization facilitates the work of the interventional radiologist at the time of injection of the complexes according to the invention. For example, during an intra-arterial injection followed under fluoroscopy, the radiologist's action will be more precise and safer by allowing an adjustment of the delivery speed of the complexes as a function of the tumor uptake of the complexes according to the invention. .
- ligand is meant a compound capable of complexing a chemical element such as a metal, preferably a radioelement.
- the ligands within the meaning of the invention are in anionic form and can complex radioelements in cationic form, for example metal cations with oxidation state (III).
- the compounds of formula (I) are ligands.
- radioelement means any known radioisotope of a chemical element, whether natural or artificially produced. According to one embodiment, the radioelement is chosen from radioisotopes of yttrium and lanthanides.
- lanthanides are designated atoms selected from the group consisting of: La, Ce, Pr, Nd, Pm, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb and Lu.
- complex means the combination of a ligand as defined above with a chemical element, preferably a radioelement as defined above.
- complex is synonymous with "chelate”.
- Thermodynamic stability represents the ligand affinity for a given element, in particular a given metal. This is the equilibrium constant of the complexation reaction:
- the complexes according to the invention are of high affinity. According to one embodiment, the complexes according to the invention have a thermodynamic equilibrium constant at least equal to 16 (LogK at least equal to 16).
- the complexes formed according to the equilibrium reaction described above are capable of dissociating under the action of various factors (pH, presence of metals or competing ligands). This dissociation can have important consequences in the context of the use of complexes in human medicine because it causes a release of the metal in the body. In order to limit this risk, complex slow dissociation are sought, that is, complexes with good kinetic inertia.
- the kinetic inertia can be determined by dissociation tests in acidic medium. These experiments lead to the determination for each complex of a half-life time (T 1/2 ) under defined conditions.
- treat means to reverse, relieve, inhibit the progression of, disorder or condition to which this term is applicable, or one or more symptoms. of such a disorder.
- the term “medical imaging” refers to the means of acquiring and restoring images of the human or animal body from various physical phenomena such as X-ray absorption, nuclear magnetic resonance, ultrasonic wave reflection or radioactivity.
- the term “medical imaging” refers to X-ray imaging, MRI (Magnetic Resonance Imaging), single photon emission computed tomography (SPECT) or Single Photon Emission Computed Tomography (SPECT). ), positron emission tomoscintigraphy (PET) and luminescence.
- the medical imaging method is X-ray imaging.
- the medical imaging method is MRI if the complex according to the invention comprises Gd (III), SPECT if the complex according to the invention comprises a gamma and PET emitter if the complex according to the invention comprises a beta + emitter.
- 1 / T2 protons of water is measured by a magnitude, relaxivity.
- the relaxivity (r) of a contrast agent is defined as the rate of relaxation, normalized by the concentration of the contrast agent.
- (C 1 -C 20 ) alkyl refers to saturated aliphatic hydrocarbons, which may be linear or branched and comprise from 1 to 20 carbon atoms. Preferably, the alkyls comprise 1 to 15 carbon atoms, for example 6, 7, 8, 9, 10, 1 1, 12, 13, 14 or 15 carbon atoms. By “branched” is meant that an alkyl group is substituted on the main alkyl chain.
- (CrC 2 o) alkylene denotes an alkyl radical as defined above, which is divalent.
- (C 2 -C 20 ) alkene denotes an alkyl as defined above, comprising at least one carbon-carbon double bond.
- (C 2 -C 20 ) alkyne denotes an alkyl as defined above, comprising at least one carbon-carbon triple bond.
- (C 6 -C 10 ) aryl denotes monocyclic, bicyclic or tricyclic hydrocarbon aromatic compounds, in particular phenyl and naphthyl.
- arylene refers to an aryl as defined above, divalent, in particular phenylene and naphthylene.
- halogen means F, Cl, Br, I and At.
- the compounds of general formula (I) comprise 1 or 2 heteroatoms.
- -O- (C 1 -C 20 ) alkyl also referred to as alkoxy
- -O- (C 2 - 2 O) alkenyl and -O- (C 2 -C 2 O) alkynyl groups are present.
- LIPIODOL refers to an iodized oil and preferably to the pharmaceutical specialty LIPIODOL ® injectable solution manufactured and marketed by Guerbet and consisting of ethyl esters of iodized fatty acids of the carnation oil.
- LIPIODOL ® is a product especially used for visualization, localization and / or vectorization during transarterial chemoembolization of hepatocellular carcinoma at the intermediate stage, in adults, as well as for the diagnosis by hepatic arterial pathway of hepatic extension. malignant liver lesions or not.
- organic acid or organic acid function
- organic acid an organic compound (or an organic function) having acidic properties, that is to say capable of releasing a cation H + , or H 3 0 + in aqueous media.
- organic acids there may be mentioned carboxylic acids, sulfonic acids, phosphates and phosphonates.
- the organic acid functional groups according to the invention are chosen from the group consisting of -COOH, -SO 2 OH, -P (O) OH, -P (O) (OH) 2, and -O-P (0 ) (OH) 2 , and more preferably -COOH.
- Such acidic functions are salifiable and may be in their basic form.
- these acidic functions are in the form of pharmaceutically acceptable salts, as defined below; for example, in the form of sodium salt or meglumine (1-Deoxy-1 - (methylamino) -D-glucitol or / V-Methyl-D-glucamine).
- fatty acid refers to saturated or unsaturated aliphatic carboxylic acids having a carbon chain of at least 4 carbon atoms. Natural fatty acids have a carbon chain of 4 to 28 carbon atoms (usually an even number). It is called a “long chain fatty acid” for a length of 14 to 22 carbons and a very long chain if there are more than 22 carbons. On the contrary, we speak of "short chain fatty acid” for a length of 4 with 10 carbons, especially 6 to 10 carbon atoms, in particular 8 or 10 carbon atoms. The skilled person knows the associated nomenclature and in particular uses:
- Ci-Cp to denote a range of C1 to Cp fatty acids
- C14-C18 fatty acids the total of the C16 fatty acids and C18 fatty acids is written as C16 + C18.
- Ci i is the number of carbon atoms of the fatty acid. Palmitic acid will for example be designated by the nomenclature (C16: 0).
- Ci x nN
- N will be the position of the double bond in the unsaturated fatty acid starting from the carbon opposite the acid group
- i is the number of atoms of carbon of the fatty acid
- x is the number of double bonds (unsaturations) of this fatty acid.
- the oleic acid for example, will be designated by the nomenclature (C18: 1 n-9).
- the iodinated oil according to the invention comprises or consists of iodinated fatty acid derivatives, preferably ethyl esters of iodinated fatty acids, more preferably ethyl esters of iodized fatty acids of iodinated fatty acids. carnation, olive oil, rapeseed oil, peanut oil, soybean oil or nut oil, more preferably fatty acid ethyl esters iodized with carnation oil or olive oil. More preferably, the iodinated oil according to the invention comprises or consists of ethyl esters of iodized fatty acids of carnation oil (also called black poppy or Papaver somniferum var nigrum).
- Poppy seed oil also known as poppy seed oil or poppy seed oil, preferably contains more than 80% unsaturated fatty acids (especially linoleic acid (C18: 2 n-6) and oleic acid (C18: 1 n-9)) of which at least 70% linoleic acid and at least 10% oleic acid.
- the iodinated oil is obtained from the complete iodination of an oil such as carnation oil under conditions allowing binding of one iodine atom for each double bond of the unsaturated fatty acids (Wolff et al. 2001, Medicine 80, 20-36) followed by trans-esterification.
- the iodinated oil according to the invention preferably contains 29 to 53% (w / w), more preferably 37% to 39% (w / w) of iodine.
- iodinated oils examples include Lipiodol ® , Brassiodol ® (derived from rapeseed oil (Brassica compestis), Yodiol ® (from peanut oil), Oriodol ® (derived from the carnation oil but in the form of triglycerides of fatty acids), Duroliopaque ® (derived from olive oil).
- the iodinated oil is Lipiodol, an iodinated oil used as a contrast medium and in certain interventional radiology procedures. This oil is a mixture of ethyl esters of iodized and non-iodized fatty acids of carnation seed oil.
- iodinated oil can also be an oil based monoiodinated ethyl ester of stearic acid (C18: 0) derived from olive oil.
- Duroliopaque ® was marketed a few years ago.
- Lipiodol The main features of Lipiodol are:
- the compounds of general formula (I) may have centers of chirality and may be in racemic or enantiomeric form.
- the compounds of general formula (I) are in their different forms: diastereoisomers, enantiomers or racemic mixture.
- the compounds of general formula (I) are in salt form, preferably in pharmaceutically acceptable salt form.
- pharmaceutically acceptable salt denotes, in particular, salts which make it possible to retain the properties and the biological effectiveness of the compounds according to the invention.
- pharmaceutically acceptable salts are found in Berge, et al. ((1977) J. Pharm Sd, vol.66, 1).
- compounds of formula general (I) are in the form of sodium salt or meglumine (1-Deoxy-1 - (methylamino) -D-glucitol or / V-Methyl-D-glucamine).
- the invention also relates to optical isomers (enantiomers), geometric (cis / trans or Z / E), tautomers and solvates such as hydrates of the compounds of formula (I).
- X 1; X 2 and X 3 are independently selected from the group consisting of: H, (C 1 -C 20 ) alkyl, (C 2 -C 2 O) alkenyl and (C 2 -C 20 ) alkynyl, said alkyl groups , alkenyl and alkynyl may optionally include one or more heteroatoms in their chain.
- X 1; X 2 and X 3 are independently selected from the group consisting of: H and (C 1 -C 20 ) alkyl. More particularly X 1; X 2 and X 3 are H.
- radicals Y 1; Y 2 or Y 3 represent a group of formula (II)
- the corresponding radicals R 1 and R 2, R 3 and R 4 or R 5 and R 6 represent H.
- the radicals R 1; R 2, R 3 , R 4, R 5 and R 6 represent independently of each other H or a group (CrC 20 ) alkyl. According to a particular embodiment, R 1; R 2, R 3 , R 4, R 5 and R 6 represent H.
- the radicals R 1 are chosen independently of each other from the group consisting of: H, (C 1 -C 20 ) alkyl, (C 2 -C 20 ) alkenyl and (C 2 -C 20 ) alkynyl, said groups alkyl, alkenyl and alkynyl may optionally comprise one or more heteroatom (s) chosen from N, O or S.
- the radicals R 1 are independently selected from the group consisting of: H, (C 1 -C 20 ) alkyl, (C 2 -C 20 ) alkenyl and (C 2 -C 20 ) alkynyl.
- radicals R 1 are chosen independently of each other from the group consisting of: H and (C 2 -C 15 ) alkynyl.
- the group of formula (II) is the following group:
- Ru R 2i R 3, R 4, R 5 and R 6 are H; and the radicals Y 1 , Y 2 and ⁇ 3 represent either a C (O) OH group or a compound of the following formula:
- the ligand according to the invention has the following general formula (I-1):
- R 1; R 2 , R 3 , R 4 , R 5 and R 6 represent independently of each other H or a (C 1 -C 20 ) alkyl group;
- Y 1 , Y 2 and Y 3 represent, independently of one another, a C (O) OH group or a group of formula II) that follows:
- the radicals R 1 are independently selected from the group consisting of: H, (C 1 -C 20 ) alkyl, (C 2 -C 20 ) alkenyl and (C 2 -C 20 ) alkynyl, said alkyl, alkenyl and alkynyl groups being optionally include one or more heteroatoms in their chain; and at least one of the radicals Y 1 , Y 2 and Y 3 being a group of formula (II);
- the compounds of general formula (I) may be symmetrical or asymmetrical.
- the compounds of general formula (I) are symmetrical when the groups -C (R 1) (R 2 ) -Y 1 and -C (R 5 ) (R 6 ) -Y 3 are identical.
- the compounds of general formula (I) are asymmetric when the groups -C (R 1) (R 2 ) -Y 1 and -C (R 5 ) (R 6) -Y 3 are different.
- the alkyl, alkenyl, alkynyl and aryl groups present in the radicals R 1 are optionally substituted by one or more substituents (s), preferably a substituent, chosen from the group consisting of -COOH, S0 2 OH, -P (O) (OH) 2, and -O-P (O) (OH) 2 ; while the alkyl, alkenyl, alkynyl, alkylene and aryl groups of the radicals R 1 to R 6 and X 1 to X 3 are not substituted by said groups.
- substituents preferably a substituent, chosen from the group consisting of -COOH, S0 2 OH, -P (O) (OH) 2, and -O-P (O) (OH) 2 ; while the alkyl, alkenyl, alkynyl, alkylene and aryl groups of the radicals R 1 to R 6 and X 1 to X 3 are not substituted by said groups.
- said alkyl, alkenyl, alkynyl and aryl groups, preferably alkyl may optionally be substituted by one or more substituents, preferably a substituent, selected from the group consisting of -COOH, -SO 2 OH, -P (O) (OH) 2, and -O-P (O) (OH) 2.
- the alkyl, alkylene and aryl groups may optionally be substituted by one or more substituents, preferably a substituent, selected from the group consisting of -COOH, -SO 2 OH, -P (O) (OH) 2, and -O-P (O) (OH) 2 .
- the alkyl, alkenyl, alkynyl and aryl groups, preferably alkynyl may optionally be substituted by one or more substituents, preferably a substituent, selected from the group consisting of -COOH, -SO 2 OH, -P (O) (OH) 2, and -O-P (O) (OH) 2.
- said substituent is a -COOH group.
- the compound of formula (I) is chosen from the group consisting of the following compounds: ⁇
- the compound of formula (I) is the following compound:
- the invention also relates to a complex of a compound of formula (I) or a salt thereof, as defined above, with a chemical element M, preferably a metal.
- the chemical element M is a metal cation selected from the group consisting of bismuth (III), lead (II), copper (II), copper (I), gallium (III), zirconium (IV) , technetium (III), indium (III), rhenium (VI), astate (III), yttrium (III), samarium (III), actinium (III), lutetium (III), terbium (III), holmium (III) gadolinium (III), europium (III) and yttrium (III), preferably gadolinium (III).
- a metal cation selected from the group consisting of bismuth (III), lead (II), copper (II), copper (I), gallium (III), zirconium (IV) , technetium (III), indium (III), rhenium (VI), astate (III), yttrium (III), samarium (III), actinium (III), lutetium (III), terbium
- the chemical element M is a radioelement chosen from the group consisting of 212 Bi ( 212 Pb), 213 Bi (III), 64 Cu (II), 67 Cu (II), 68 Ga (III) ), 8 9 Zr (IV), 99m Tc (III), 111 In (III), 186 Re (VI), 188 Re (VI), 211 At (III), 225 Ac (III), 153 Sm (l II ), 149 Tb (III), 166 Ho (III), 212 Bi ( 212 Pb), 213 Bi (III), preferably 177 Lu (III), 90 Y (III) and 166 Ho (III).
- M is a radioelement chosen from the radioactive isotopes of yttrium and lanthanides.
- M is a radioelement chosen from the group consisting of 166 Ho, 177 Lu and 90 Y.
- said complex has the following general formula (III):
- each of the groups Y 1; Y 2 and Y 3 comprise a group C (O) O " , allowing complexation with the element M.
- the invention also relates to a pharmaceutical composition
- a pharmaceutical composition comprising a compound of formula (I) as defined above or a complex as defined above, and optionally one or more pharmaceutically acceptable excipient (s).
- the composition may further comprise a buffer selected from the buffers of established use, for example the buffers lactate, tartrate malate, maleate, succinate, ascorbate, carbonate, Tris ((hydroxymethyl) aminomethane), HEPES (2- [4- acid (2-hydroxyethyl) -1-piperazine] ethanesulfonic acid), MES (2-morpholino ethanesulfonic acid) and mixtures thereof.
- a buffer selected from the buffers of established use, for example the buffers lactate, tartrate malate, maleate, succinate, ascorbate, carbonate, Tris ((hydroxymethyl) aminomethane), HEPES (2- [4- acid (2-hydroxyethyl) -1-piperazine] ethanesulfonic acid), MES (2-morpholino ethanesulfonic acid) and mixtures thereof.
- the pharmaceutical composition may comprise an oily phase, especially an iodinated oil.
- the pharmaceutical composition further comprises ethyl esters of iodized fatty acids of the carnation oil.
- the pharmaceutical composition according to the invention consists of an iodized oil and complexes according to the invention.
- the pharmaceutical composition according to the invention consists of LIPIODOL® and complexes according to the invention.
- LIPIODOL® is composed of ethyl esters of iodized fatty acids of carnation oil.
- the pharmaceutical composition according to the invention is radio-opaque, and therefore visible by X-ray radiography.
- the pharmaceutical composition is an injectable composition.
- the pharmaceutical composition according to the invention is administered by intra-arterial hepatic injection.
- the invention relates to a complex or a pharmaceutical composition as defined above, for its use in the treatment of cancers.
- the invention also relates to a complex or a pharmaceutical composition as defined above, for its use in medical imaging.
- the invention relates to the use of a complex as defined above for the preparation of a medicament for the treatment of cancers.
- the invention also relates to the use of a complex or a pharmaceutical composition as defined above in medical imaging.
- the invention relates to a method of therapeutic treatment of a patient suffering from a cancer, comprising the administration to said patient of a complex or a pharmaceutical composition as defined above.
- said method of treatment does not include a surgical treatment step.
- the invention also relates to a method for medical imaging of a tumor comprising:
- a step of detecting the tumor by a medical imaging method a step of detecting the tumor by a medical imaging method.
- cancer abnormal cell proliferation (also called tumor) within a normal tissue of the body.
- cancerous cells are all derived from a single clone, a cancer-initiating cell that has acquired certain characteristics that allow it to divide indefinitely. During the evolution of the tumor, some cancer cells can migrate out of their place of production and form metastases.
- liver cancers in particular primary cancers of the liver, preferably hepatocarcinomas.
- hepatocarcinoma preferably epithelioid hemangioendothelioma
- cholangiocarcinoma cholangiocarcinoma
- neurological tumors endocrine
- metastasis of other cancers such as metastases of colorectal cancer.
- the cancer is an intermediate stage hepatocellular carcinoma in adults.
- the compounds of general formula (I) can be prepared according to two processes, depending on whether the compounds of general formula (I) are symmetrical or asymmetrical.
- the deprotection steps are known to those skilled in the art and correspond to conventional hydrolysis reactions of an amide.
- the functionalization steps are also known to those skilled in the art and correspond to conventional alkylation reactions (see Loic Bellouard, CHEM S Perkin 1, (23), 1999, pp. 3499-3505).
- the first applicable approach for the symmetrical compounds involves the total synthesis of the pyclene macrocycle with the need to differentiate the central nitrogen atom (6) from the nitrogen atoms in lateral positions (3 and 9).
- X 1, X 2 and X 3 are as defined for the compounds of general formula (I)
- the group Ra is a group -C (R 3 ) (R 4 ) -Y 2 , with R 3 , R 4 and Y 2 as defined for compounds of general formula (I)
- an ester or an orthogonal protecting group such as tert-butoxycarbonyl
- Z is a leaving group such as Cl, Br, I, tosylate mesylate or triflate.
- This method of preparation is called “Direct Way” or "Boc Way” in the examples.
- the invention also relates to a process for the preparation of the compounds of general formula (I) according to the invention being asymmetrical.
- This preparation process is advantageously based on the reaction of a diester of oxalic acid with pyclene which makes it possible to block two nitrogen atoms of the pyclene (N-6 and N-9) so as to be able to intervene selectively on the third atom (N-3) left free.
- X 1; X 2 , X 3 , R 1 to R 6 and Y 1 to Y 3 are as defined for the compounds of general formula (I).
- the protection step is carried out in the presence of methanol.
- the invention relates to a process for preparing compounds of general formula (I) for which the groups -C (R 1) (R 2 ) -Y 1 and -C (R 5 ) (R 6 ) -Y 3 are different, comprising a step functionalizing a compound of general formula (IX) below:
- said method of preparation further comprises:
- Functionalization means the addition to a nitrogen atom of a group - C (R 1) (R 2 ) -Y 1, -C (R 3 ) (R 4 ) -Y 2 or -C (R 5 ) (R 6 ) -Y 3 .
- the invention also relates to a compound of the following general formula (X)
- the preparation of a substituted picolinate intermediate is carried out via a brominated derivative in the 4-position.
- a coupling reaction with an alkyne catalyzed with palladium (so-called Sonogashira reaction, Comprehensive Chirality, Volume 4, Pages18- 32, 2012), to install the residue chosen, according to scheme 3 below (example with a C12 alkyne):
- the invention also relates to a method for radiolabeling compounds of general formula (I).
- Said radiolabeling process is preferably carried out at a pH between 6.5 and 9.
- said radiolabeling is carried out in the presence of acetate buffer.
- the radiolabeling is carried out in the presence of water or alcohol such as ethanol, or mixtures thereof.
- the radiolabeling is carried out at a temperature of between 80 ° C. and 100 ° C.
- FIG. 1 1 H NMR spectra of the ligand P04213 and its yttrium complex P04183 (300 MHz, 298 K, D 2 0)
- Figure 2 Absorption spectra of ligands and their yttrium complexes recorded in water at pH 3.8 and 5.5 (acetate buffer).
- the absorption band corresponding to the ⁇ - ⁇ * transitions of pyridine ranges from 240 to 300 nm for ligands and complexes.
- Figure 3 Monitoring the variation of the Amax absorbance of the complex or ligand at pH 5.5 and 3.8.
- Figure 4 1 H NMR spectrum of the ligand P04330.
- Figure 5 Percentage extraction of complex P04283 to IY as a function of time, in hours (Re-SSS is a reference complex).
- Yttrium-90 chloride is purchased from PerkinElmer Life Sciences. The activities involved ranged from 28 ⁇ to 8.51 mCi (1.04 - 314.87 MBq). The products (HPLC solvents, buffers, ...) are used as they are, without additional purification. Except if otherwise specified, the ligand is solubilized in ethanol.
- the quality controls were carried out by TLC on Whatman 1 paper, eluting with a MeOH / NEt 3 0.1% mixture. Radiochemical purities are determined using a Cyclone phosphoimageur (Perkin Elmer), using Optiquant software.
- HPLC analyzes were also performed on a Dionex Ultimate 3000 HPLC chain equipped with a diode array detector and a fLumo (Berthold) radiochromatic detector, driven by Chromeleon software.
- are defined by / 3M m H h L
- ] / [H] h [L] i and ⁇ ⁇ ⁇ ( ⁇ ) ⁇ Ke).
- the log unit differences between the protonation (or hydrolysis) values and the non-protonation constants give the intermediate reaction constants (log K) (with M m H h L
- [M m H h L
- the errors indicated are the standard deviations calculated by the adjustment program from the set of experimental data for each system.
- the HPLC chromatography system uses a column (VisionHT C18 HL 5 ⁇ 250 x 10 mm) eluted with an isocratic gradient H 2 0 (with 0.1% TFA or HCl) -MeCN
- the 1 H NMR and 13 C NMR spectra were recorded on a Bruker AMX3-300 MHz spectrometer operating at 300.17 and 75.47 MHz, respectively for 1 H and 13 C. All measurements were carried out at 25 ° C.
- the signals are indicated as such: ⁇ chemical shift (ppm), multiplicity (s, singlet, d, doublet, t, triplet, m, multiplet, q, quadruplet), integration, coupling constants J in hertz (Hz).
- HRMS-ESI High resolution mass spectrometry
- ESI + electrospray positive ionization
- the white solid obtained is chromatographed on silica gel (ethyl acetate / pentane: 5/5 to 8/2) to give a white product after evaporation of the solvent (2.9 g, 51% shim, initially from 1 ).
- the chloromethylpyridine-2-carboxylic acid methyl ester was added to a solution of the compound 4 "(0.939 g, 3.38 mmol) in acetonitrile (150 mL) in the presence of K 2 CO 3 (1.8 g, 13.5 mmol). The mixture was stirred at room temperature for one week, then filtered and concentrated, and the crude product was purified by alumina column chromatography (CH 2 Cl 2 / MeOH 98/2) to give the title compound. as yellow oil (0.822 g, 42%).
- the P04213 ligand is solubilized in ultrapure water, the pH is adjusted to 5 with 1M sodium hydroxide solution.
- the salt YCI 3 .6H 2 O (1.5 eq) is dissolved in water. ultra pure water. While stirring, the yttrium solution is added to the ligand solution. After adjusting the pH to 5, the solution is refluxed overnight.
- the complex is then purified by HPLC on C18 (H 2 O / ACN: 100/0 to 10/90) according to the scheme below:
- the ligand P04214 was engaged in a complexation reaction with yttrium 90 in order to confirm the complexation results obtained with non-radioactive natural yttrium. A radiolabeling study was carried out.
- the radiolabeling efficiency obtained is> 90% (P04233).
- the optimal marking conditions are:
- the purification of the complexes is carried out by preparative HPLC in order to be able to eliminate the remaining salts.
- Equation 1 General formula for calculating the relaxivity value r1 and r2
- M3 + Y 3+, Gd3 +, Eu3 +, Tb3 +, Yb3 +, Lu3 +
- M3 + Y 3+, Gd3 +, Eu3 +, Tb3 +, Yb3 +, Lu3 +
- M3 + Y 3+, Gd3 +, Eu3 +, Tb3 +, Yb3 +, Lu3 +
- the absorption spectra of the ligands and their yttrium complexes were recorded in water at pH 3.8 and 5.5 (acetate buffer).
- the absorption band corresponding to the ⁇ - ⁇ * transitions of pyridine ranges from 240 to 300 nm for ligands and complexes (see Figure 2).
- P04214 and Pc2a1 pa sym P04218 with yttrium were studied at pH 3.8 and pH 5.5 in acetate buffer medium by UV-Visible spectroscopy. Placed at the maximum absorption of the complex, the increase in the absorbance intensity is measured every two seconds until the maximum absorbance is reached. The decrease in absorbance intensity at the maximum absorption of the ligand is monitored when the absorption band of the complex is masked by that of the ligand.
- the concentration of ligands Pc1 a2pa sym and asym a2pa Pc1 is 4.10 "5 M and 8.10" 5 M for the ligand Pc2a1 pa sym.
- the Pc1 a2pa sym ligand exhibits the fastest complexation kinetics with complete complexation in respectively 30 and 400 seconds.
- the complexation is total in 1 100 seconds at pH 3.8 and 100 seconds at pH 5.5. The complexation is therefore rapid for all the ligands under the conditions studied, (see Figure 3).
- the kinetics of dissociation of the complexes in concentrated acid medium makes it possible to know the behavior of the complexes in a very competitive medium.
- the absorption band of the complex disappears more or less rapidly to reveal the absorption band of the ligand at lower wavelengths.
- PCTMB Phosphonic acid, ⁇ , ⁇ ', ⁇ "- [3,6,9,15-tetraazabicyclo [9.3.1] pentadeca-1 (15), 1 1, 13-triene -3,6,9-triyltris (m ⁇ , ⁇ ', ⁇ ''- tributyl ester) as well as with those described in the literature in particular for PCTA (3,6,9,15-tetraazabicyclo [9.3.1] pentadeca-1 (15), 1 1, 13-triene-3,6,9-triacetic acid), EDTA (Ethylenediaminetetraacetic acid) and DOTA (1, 4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid.
- the refinement of the titration curves with the HyperQuad software makes it possible to determine the global constants (log ⁇ ), from which the partial constants (log K) are calculated.
- the values of the log K YL constants of the ligands Pc1 a2pa sym, Pc1 a2pa asym and Pc2a1 pa sym are respectively 19.78, 19.49, 19.28 and those of constants log ⁇ ⁇ "1 are 1 1 .84, 1 1 .79 and 10.60 .
- pM -loglM] *
- thermodynamic stability constants of the yttrium complexes indicate that the complexes exist exclusively in the YL form over a wide pH range, including pH 7.4.
- the yttrium complex P04183 crystallizes in water.
- the structure obtained by X-ray diffraction is presented below.
- the metal is coordinated by the four nitrogen atoms of the macrocycle, the two nitrogen atoms of the picolinate arms and the three oxygen atoms of the carboxylic acids.
- the coordination sphere of the metal is N603, ie 9 coordinating atoms.
- the helicities ⁇ and ⁇ resulting from the orientation of the picolinate and acetate arms are both present, the complex thus crystallizes as a racemic mixture.
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ES16816710T ES2760957T3 (es) | 2015-12-24 | 2016-12-23 | Ligandos macrocíclicos con uno o varios grupos picolinato, sus complejos así como sus utilizaciones médicas |
CN201680075995.5A CN108884095B (zh) | 2015-12-24 | 2016-12-23 | 具有吡啶甲酸酯基团的大环配体、其络合物及其医学用途 |
CA3008913A CA3008913C (fr) | 2015-12-24 | 2016-12-23 | Ligands macrocycliques avec groupement(s) picolinate(s), leurs complexes ainsi que leurs utilisations medicales |
JP2018552912A JP6813151B2 (ja) | 2015-12-24 | 2016-12-23 | ピコリナート基を有する大環状配位子、その錯体、及びその医学的使用 |
BR112018012939-9A BR112018012939B1 (pt) | 2015-12-24 | 2016-12-23 | Compostos, complexo de um composto, usos de um complexo, composição farmacêutica e processo para preparação dos compostos |
PL16816710T PL3394063T3 (pl) | 2015-12-24 | 2016-12-23 | Makrocykliczne ligandy z grupą (grupami) pikolinianową, ich kompleksy, jak również zastosowania medyczne |
MX2018007739A MX2018007739A (es) | 2015-12-24 | 2016-12-23 | Ligandos macrociclicos con uno o varios grupos picolinato, sus complejos así como sus utilizaciones medicas. |
EP16816710.4A EP3394063B1 (fr) | 2015-12-24 | 2016-12-23 | Ligands macrocycliques avec groupement(s) picolinate(s), leurs complexes ainsi que leurs utilisations médicales |
AU2016375192A AU2016375192B2 (en) | 2015-12-24 | 2016-12-23 | Macrocyclic ligands with picolinate group(s), complexes thereof and also medical uses thereof |
KR1020187017903A KR20180117594A (ko) | 2015-12-24 | 2016-12-23 | 피콜리네이트 기(들)를 갖는 마크로사이클릭 리간드, 이의 착물, 및 또한 이의 의학적 용도 |
US16/065,661 US10711001B2 (en) | 2015-12-24 | 2016-12-23 | Macrocylic ligands with picolinate group(s), complexes thereof and also medical uses thereof |
US16/658,377 US10981912B2 (en) | 2015-12-24 | 2019-10-21 | Macrocyclic ligands with picolinate group(s), complexes thereof and also medical uses thereof |
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WO2019002505A1 (fr) * | 2017-06-28 | 2019-01-03 | Guerbet | Ligands macrocycliques renforcés, leurs complexes ainsi que leurs utilisations |
WO2019185901A1 (fr) | 2018-03-30 | 2019-10-03 | Centre National De La Recherche Scientifique | Ligands macrocycliques à base de pyclen, leurs chélates et leurs utilisations |
EP4124361A1 (fr) | 2021-07-30 | 2023-02-01 | Guerbet | Ligands macrocycliques avec groupement(s) picolinate(s), leurs complexes ainsi que leurs utilisations medicales |
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US9721551B2 (en) | 2015-09-29 | 2017-08-01 | Amper Music, Inc. | Machines, systems, processes for automated music composition and generation employing linguistic and/or graphical icon based musical experience descriptions |
US11037538B2 (en) | 2019-10-15 | 2021-06-15 | Shutterstock, Inc. | Method of and system for automated musical arrangement and musical instrument performance style transformation supported within an automated music performance system |
US10964299B1 (en) | 2019-10-15 | 2021-03-30 | Shutterstock, Inc. | Method of and system for automatically generating digital performances of music compositions using notes selected from virtual musical instruments based on the music-theoretic states of the music compositions |
US11024275B2 (en) | 2019-10-15 | 2021-06-01 | Shutterstock, Inc. | Method of digitally performing a music composition using virtual musical instruments having performance logic executing within a virtual musical instrument (VMI) library management system |
JP2024125438A (ja) * | 2021-08-03 | 2024-09-19 | 住友化学株式会社 | 放射性金属錯体及びその製造方法、並びに放射性金属捕捉剤 |
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EP0391766A1 (fr) * | 1989-03-24 | 1990-10-10 | Guerbet S.A. | Nouveaux ligands macrocycliques azotés, procédé de préparation, complexes métalliques formés par ces ligands, composition de diagnostic et composition thérapeutique les contenant |
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Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2019002505A1 (fr) * | 2017-06-28 | 2019-01-03 | Guerbet | Ligands macrocycliques renforcés, leurs complexes ainsi que leurs utilisations |
FR3068355A1 (fr) * | 2017-06-28 | 2019-01-04 | Guerbet | Ligands macrocycliques renforces, leurs complexes ainsi que leurs utilisations |
US11155553B2 (en) | 2017-06-28 | 2021-10-26 | Guerbet | Reinforced macrocyclic ligands, complexes thereof, and uses of same |
WO2019185901A1 (fr) | 2018-03-30 | 2019-10-03 | Centre National De La Recherche Scientifique | Ligands macrocycliques à base de pyclen, leurs chélates et leurs utilisations |
US12103927B2 (en) | 2018-03-30 | 2024-10-01 | Centre National De La Recherche Scientifique | Pyclen-based macrocyclic ligands, chelates thereof and uses thereof |
EP4124361A1 (fr) | 2021-07-30 | 2023-02-01 | Guerbet | Ligands macrocycliques avec groupement(s) picolinate(s), leurs complexes ainsi que leurs utilisations medicales |
WO2023006938A1 (fr) | 2021-07-30 | 2023-02-02 | Guerbet | Ligands macrocycliques avec groupement(s) picolinate(s), leurs complexes ainsi que leurs utilisations medicales |
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US10711001B2 (en) | 2020-07-14 |
FR3046172B1 (fr) | 2019-05-31 |
CN108884095A (zh) | 2018-11-23 |
BR112018012939A2 (pt) | 2018-12-11 |
MX2018007739A (es) | 2018-11-09 |
AU2016375192B2 (en) | 2020-06-11 |
US10981912B2 (en) | 2021-04-20 |
PL3394063T3 (pl) | 2020-06-29 |
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FR3046172A1 (fr) | 2017-06-30 |
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AU2016375192A1 (en) | 2018-07-12 |
US20190023705A1 (en) | 2019-01-24 |
US20200123155A1 (en) | 2020-04-23 |
AU2016375192A2 (en) | 2018-09-20 |
JP6813151B2 (ja) | 2021-01-13 |
PT3394063T (pt) | 2020-01-03 |
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EP3394063B1 (fr) | 2019-10-02 |
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