WO2017089780A3 - Peptides - Google Patents

Peptides Download PDF

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Publication number
WO2017089780A3
WO2017089780A3 PCT/GB2016/053662 GB2016053662W WO2017089780A3 WO 2017089780 A3 WO2017089780 A3 WO 2017089780A3 GB 2016053662 W GB2016053662 W GB 2016053662W WO 2017089780 A3 WO2017089780 A3 WO 2017089780A3
Authority
WO
WIPO (PCT)
Prior art keywords
peptides
complexes
present
mhc molecules
moieties
Prior art date
Application number
PCT/GB2016/053662
Other languages
English (en)
Other versions
WO2017089780A2 (fr
Inventor
Alex POWLESLAND
Fiona CHESTER
Meidai SUN
Original Assignee
Immunocore Limited
Adaptimmune Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunocore Limited, Adaptimmune Limited filed Critical Immunocore Limited
Publication of WO2017089780A2 publication Critical patent/WO2017089780A2/fr
Publication of WO2017089780A3 publication Critical patent/WO2017089780A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4738—Cell cycle regulated proteins, e.g. cyclin, CDC, INK-CCR
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/605—MHC molecules or ligands thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Cell Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La présente invention concerne de nouveaux peptides dérivés de claspine (CLSPN), des complexes comprenant ces peptides liés à des molécules recombinantes du CMH, et des cellules présentant ledit peptide en complexe avec des molécules du CMH. L'invention concerne également des fractions de fixation qui se lient auxdits peptides et/ou auxdits complexes. Ces fractions sont utiles dans le développement de réactifs immunothérapeutiques pour le traitement de maladies telles que le cancer.
PCT/GB2016/053662 2015-11-23 2016-11-23 Peptides WO2017089780A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB1520579.2 2015-11-23
GBGB1520579.2A GB201520579D0 (en) 2015-11-23 2015-11-23 Peptides

Publications (2)

Publication Number Publication Date
WO2017089780A2 WO2017089780A2 (fr) 2017-06-01
WO2017089780A3 true WO2017089780A3 (fr) 2017-07-27

Family

ID=55133178

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2016/053662 WO2017089780A2 (fr) 2015-11-23 2016-11-23 Peptides

Country Status (2)

Country Link
GB (1) GB201520579D0 (fr)
WO (1) WO2017089780A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110785183A (zh) 2017-07-07 2020-02-11 伊玛提克斯生物技术有限公司 用于肺癌(包括nsclc、sclc和其他癌症)免疫治疗的新型肽和肽组合物
US10800823B2 (en) 2017-07-07 2020-10-13 Immatics Biotechnologies Gmbh Peptides and combination of peptides for use in immunotherapy against lung cancer, including NSCLC, SCLC and other cancers
DE102018107224A1 (de) 2018-02-21 2019-08-22 Immatics Biotechnologies Gmbh Peptide und Kombinationen von Peptiden nicht-kanonischen Ursprungs zur Verwendung in der Immuntherapie gegen verschiedene Krebsarten
WO2022210863A1 (fr) * 2021-03-30 2022-10-06 北海道公立大学法人 札幌医科大学 Peptide d'antigène exprimé dans des cellules souches cancéreuses de la vessie humaine

Citations (9)

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Publication number Priority date Publication date Assignee Title
EP1972639A2 (fr) * 2007-03-07 2008-09-24 Cell Signaling Technology, Inc. Réactifs pour la détection de la phosphorylation de protéines dans des voies signalant un carcinome
WO2010046469A1 (fr) * 2008-10-24 2010-04-29 Basisnote Ag Kit de test destiné à déterminer les préférences d’odeurs et de profils d’odeurs
WO2011038002A1 (fr) * 2009-09-22 2011-03-31 Yale University Epitopes immunogènes en tant que cibles pour des vaccins universels contre le cancer
WO2013002086A1 (fr) * 2011-06-28 2013-01-03 株式会社癌免疫研究所 Gène récepteur pour un lymphocyte t spécifique d'un antigène cancéreux peptidique
WO2013040142A2 (fr) * 2011-09-16 2013-03-21 Iogenetics, Llc Procédés bio-informatiques de détermination de liaisons peptidiques
WO2013102680A1 (fr) * 2012-01-05 2013-07-11 Centre National De La Recherche Scientifique (Cnrs) Signature pour le diagnostic de l'agressivité et de l'instabilité génétique du cancer du poumon
WO2014200910A2 (fr) * 2013-06-10 2014-12-18 Iogenetics, Llc Procédés bio-informatiques de détermination de liaisons peptidiques
WO2015140567A1 (fr) * 2014-03-21 2015-09-24 Immunocore Limited Antigènes associés aux tumeur dérivés de la protéine traip
WO2016172722A1 (fr) * 2015-04-23 2016-10-27 Nantomics, Llc Néo-épitopes de cancer

Family Cites Families (15)

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GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
JPS61134325A (ja) 1984-12-04 1986-06-21 Teijin Ltd ハイブリツド抗体遺伝子の発現方法
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
AU690528B2 (en) 1992-12-04 1998-04-30 Medical Research Council Multivalent and multispecific binding proteins, their manufacture and use
US6300065B1 (en) 1996-05-31 2001-10-09 Board Of Trustees Of The University Of Illinois Yeast cell surface display of proteins and uses thereof
ATE533784T1 (de) 1997-10-02 2011-12-15 Altor Bioscience Corp Lösliche, einzelkettige proteine des t- zellrezeptors
EP2336167B1 (fr) 2001-03-14 2019-05-29 Dako Denmark A/S Nouvelles constructions de molécules MHC, méthodes d'utilisation de ces constructions à des fins de diagnostic et de therapie et utilisations de molécules MHC
PL208712B1 (pl) 2001-08-31 2011-05-31 Avidex Ltd Rozpuszczalny receptor komórek T (sTCR), rozpuszczalna αβ-postać receptora komórek T (sTCR), wielowartościowy kompleks receptora komórek T (TCR), sposób wykrywania kompleksów MHC-peptyd, środek farmaceutyczny zawierający sTCR i/lub wielowartościowy kompleks TCR, cząsteczka kwasu nukleinowego, wektor, komórka gospodarz, sposób otrzymywania całości lub części łańcucha α TCR albo całości lub części łańcucha β TCR, sposób otrzymywania rozpuszczalnego receptora komórek T (sTCR), sposób otrzymywania rozpuszczalnej αβ-postaci receptora komórek T (sTCR) oraz sposób wykrywania kompleksów MHC-peptyd
NZ570811A (en) 2002-11-09 2009-11-27 Immunocore Ltd T cell receptor display
EP2026837A4 (fr) 2006-06-01 2010-06-02 Receptor Logic Inc Anticorps utiles en tant qu'analogues de récepteur des lymphocytes t, leurs procédés de production et leurs utilisations
GB0908613D0 (en) 2009-05-20 2009-06-24 Immunocore Ltd T Cell Reseptors
US9209965B2 (en) 2014-01-14 2015-12-08 Microsemi Semiconductor Ulc Network interface with clock recovery module on line card
WO2015136072A1 (fr) 2014-03-14 2015-09-17 Immunocore Limited Banques de tcr

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1972639A2 (fr) * 2007-03-07 2008-09-24 Cell Signaling Technology, Inc. Réactifs pour la détection de la phosphorylation de protéines dans des voies signalant un carcinome
WO2010046469A1 (fr) * 2008-10-24 2010-04-29 Basisnote Ag Kit de test destiné à déterminer les préférences d’odeurs et de profils d’odeurs
WO2011038002A1 (fr) * 2009-09-22 2011-03-31 Yale University Epitopes immunogènes en tant que cibles pour des vaccins universels contre le cancer
WO2013002086A1 (fr) * 2011-06-28 2013-01-03 株式会社癌免疫研究所 Gène récepteur pour un lymphocyte t spécifique d'un antigène cancéreux peptidique
WO2013040142A2 (fr) * 2011-09-16 2013-03-21 Iogenetics, Llc Procédés bio-informatiques de détermination de liaisons peptidiques
WO2013102680A1 (fr) * 2012-01-05 2013-07-11 Centre National De La Recherche Scientifique (Cnrs) Signature pour le diagnostic de l'agressivité et de l'instabilité génétique du cancer du poumon
WO2014200910A2 (fr) * 2013-06-10 2014-12-18 Iogenetics, Llc Procédés bio-informatiques de détermination de liaisons peptidiques
WO2015140567A1 (fr) * 2014-03-21 2015-09-24 Immunocore Limited Antigènes associés aux tumeur dérivés de la protéine traip
WO2016172722A1 (fr) * 2015-04-23 2016-10-27 Nantomics, Llc Néo-épitopes de cancer

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
DATABASE Geneseq [online] 12 February 2015 (2015-02-12), "Brucella sp. MHC-I binding peptide, SEQ: 20175.", XP002766899, retrieved from EBI accession no. GSP:BBS28855 Database accession no. BBS28855 *
DATABASE Geneseq [online] 12 May 2011 (2011-05-12), "OCT4 epitope library peptide sequence, SEQ: 30.", XP002766897, retrieved from EBI accession no. GSP:AZG41718 Database accession no. AZG41718 *
DATABASE Geneseq [online] 22 June 2010 (2010-06-22), "HLA-A*03 peptide ligand sequence, SEQ ID: 209.", XP002766900, retrieved from EBI accession no. GSP:AXZ18579 Database accession no. AXZ18579 *
DATABASE Geneseq [online] 27 November 2008 (2008-11-27), "Human carcinoma-related signaling peptide, claspin, SEQ ID 55.", XP002766898, retrieved from EBI accession no. GSP:ATM92849 Database accession no. ATM92849 *
DATABASE Geneseq [online] 31 January 2013 (2013-01-31), "Human anti-WT1 T-cell receptor V beta chain CDR3 peptide, SEQ ID NO: 993.", XP002766902, retrieved from EBI accession no. GSP:BAJ30072 Database accession no. BAJ30072 *
LIN SHIAW-YIH ET AL: "Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, US, vol. 101, no. 17, 1 January 2004 (2004-01-01), pages 6484 - 6489, XP002592844, ISSN: 0027-8424, [retrieved on 20040419], DOI: 10.1073/PNAS.0401847101 *
TSIMARATOU K ET AL: "Evaluation of claspin as a proliferation marker in human cancer and normal tissues", JOURNAL OF PATHOLOGY, vol. 211, no. 3, February 2007 (2007-02-01), pages 331 - 339, XP002766901, ISSN: 0022-3417 *

Also Published As

Publication number Publication date
WO2017089780A2 (fr) 2017-06-01
GB201520579D0 (en) 2016-01-06

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