WO2017076320A1 - 用电磁场调制脑睡眠兴奋区的方法和仪器 - Google Patents

用电磁场调制脑睡眠兴奋区的方法和仪器 Download PDF

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Publication number
WO2017076320A1
WO2017076320A1 PCT/CN2016/104530 CN2016104530W WO2017076320A1 WO 2017076320 A1 WO2017076320 A1 WO 2017076320A1 CN 2016104530 W CN2016104530 W CN 2016104530W WO 2017076320 A1 WO2017076320 A1 WO 2017076320A1
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Prior art keywords
sleep
brain
electromagnetic field
excitement
aid
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PCT/CN2016/104530
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English (en)
French (fr)
Inventor
李小平
夏茜
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纽沃凯生物科技（深圳）有限公司
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Priority claimed from US14/931,869 external-priority patent/US11241187B2/en
Application filed by 纽沃凯生物科技（深圳）有限公司 filed Critical 纽沃凯生物科技（深圳）有限公司
Publication of WO2017076320A1 publication Critical patent/WO2017076320A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N2/00—Magnetotherapy

Definitions

  • the present invention provides methods and apparatus for modulating brain sleep excitatory regions with electromagnetic fields to achieve sleep aid, sleep management, and sleep therapy.
  • Sleep disorders are an urgent problem in modern people's lives.
  • the common method for solving the problem of sleep disorders is mainly the drug method.
  • the main problem of the drug law is that it will produce various side effects, such as: causing people to gradually lose memory, loss of appetite, loss of libido, damage to internal organs, dependence, and nervousness. .
  • the brain has multiple functional excitatory areas. Among them, there are awakening and excitatory areas (including: blue spot nucleus LC, lateral dorsal nucleus LDT, foot bridge nucleus PPT), sleep excitatory area (including: ventral lateral preoptic area VLPO), thalamic reticular nucleus TRN.
  • awakening and excitatory areas including: blue spot nucleus LC, lateral dorsal nucleus LDT, foot bridge nucleus PPT
  • sleep excitatory area including: ventral lateral preoptic area VLPO
  • thalamic reticular nucleus TRN thalamic reticular nucleus
  • the sleep excitatory zone increases excitement and suppresses the excitement of the awakening excitatory zone, thereby weakening the inhibition of the thalamic reticular nucleus in the awakening excitatory zone until it reaches zero.
  • the stimulating zone of the brain awakens the excitation of the thalamic reticular nucleus to zero/blocked, the thalamic reticular nucleus releases the sleep hormone to the whole brain.
  • the brain enters a sleep state. People who have difficulty falling asleep, because the various neurotransmitters in the brain can not be properly coordinated, during the sleep process, the sleep excitement zone can not normally increase the excitement, so that it can not fall asleep normally.
  • the present invention provides methods and apparatus for modulating the brain's sleep excitatory region with electromagnetic fields to help the brain enter sleep, manage sleep, and treat diseases through sleep.
  • sleep aiding the brain is achieved by generating an electromagnetic field, modulating the sleep excitatory region of the brain, and increasing the excitement so that the brain normally shifts from the awake mode to the sleep mode.
  • the sleep management of the brain is through a sleep magnetic field that modulates the brain's sleep excitatory region with an electromagnetic field, so that the brain normally shifts from the awake mode to the sleep mode sleeper and a sleep depth monitor.
  • the sleep depth monitor detects the sleep depth of the brain and controls the opening and closing of the sleep aid to regulate the sleep depth and the continuous sleep time of the brain, and achieve an index of the continuous deep sleep time of the set brain.
  • the sleep management system includes an electromagnetic field to modulate the sleep excitatory region of the brain, so as to increase the excitement, so that the brain normally switches from the awake mode to the sleep mode sleeper and a sleep depth monitor; the sleep depth monitor receives the treatment designation
  • the sleep parameters of the disease (including sleep depth and sleep time) and control of the sleep aid ensure that sleep is completed according to the specified sleep parameters.
  • Figure 1 shows three excitatory regions of the brain associated with the present invention: the wake-up excitatory region (including: the leukoplakia LC, the dorsal nucleus LDT, the foot bridge nucleus PPT), the sleep excitatory region (including: the ventrolateral anterior region VLPO) ), the thalamic reticular nucleus TRN, the relationship between the brain in a awake mode.
  • the wake-up excitatory region including: the leukoplakia LC, the dorsal nucleus LDT, the foot bridge nucleus PPT
  • the sleep excitatory region including: the ventrolateral anterior region VLPO
  • the thalamic reticular nucleus TRN the relationship between the brain in a awake mode.
  • Figure 2 shows the three excitatory regions of the brain associated with the present invention: the wake-up excitatory region (including: the leukoplakia LC, the dorsal nucleus LDT, the foot bridge nucleus PPT), the sleep excitatory region (including: the ventrolateral anterior region VLPO) ), the thalamic reticular nucleus TRN, in the brain from the state of waking to the relationship between sleep mode.
  • the wake-up excitatory region including: the leukoplakia LC, the dorsal nucleus LDT, the foot bridge nucleus PPT
  • the sleep excitatory region including: the ventrolateral anterior region VLPO
  • the thalamic reticular nucleus TRN in the brain from the state of waking to the relationship between sleep mode.
  • Figure 3 shows the three excitatory regions of the brain associated with the present invention: the wake-up excitatory region (including: the leukoplakia LC, the dorsal nucleus LDT, the foot bridge nucleus PPT), the sleep excitatory region (including: the ventrolateral anterior region VLPO) ), the thalamic reticular nucleus TRN, the relationship between the brain in sleep mode.
  • the wake-up excitatory region including: the leukoplakia LC, the dorsal nucleus LDT, the foot bridge nucleus PPT
  • the sleep excitatory region including: the ventrolateral anterior region VLPO
  • the thalamic reticular nucleus TRN the relationship between the brain in sleep mode.
  • Fig. 4 shows the use of an electromagnetic field in the present invention to modulate the sleep excitatory region of the brain to enhance excitement, so that the brain normally transitions from the awake mode to the sleep mode to achieve sleep aid.
  • Figure 5 shows the pulsed electromagnetic field of the present invention modulating the sleep excitatory region of the brain to enhance excitement so that the brain normally transitions from the awake mode to the sleep mode to achieve sleep aid.
  • Fig. 6 shows that the present invention generates an electromagnetic field from the back of the brain to the brain, and by modulating the sleep excitatory region of the brain to enhance the excitement, so that the brain normally shifts from the awake mode to the sleep mode to achieve sleep aid.
  • Fig. 7 shows that the present invention generates an electromagnetic field from the upper part of the brain to the brain, and by modulating the sleep excitatory region of the brain to enhance the excitement, so that the brain normally shifts from the awake mode to the sleep mode to achieve sleep aid.
  • Fig. 8 shows that the present invention generates an electromagnetic field from the front of the brain to the brain, and by modulating the sleep excitatory region of the brain to enhance the excitement, so that the brain normally shifts from the awake mode to the sleep mode to achieve sleep aid.
  • Figure 9 shows that the two electromagnetic field driving power sources of the present invention each drive an antenna to generate two electromagnetic fields from the left and right sides of the brain, and by modulating the sleep excitation region of the brain, the excitement is increased, so that the brain normally shifts from the awake mode to the sleep. Mode to help sleep.
  • Figure 10 shows an electromagnetic field driving power supply of the present invention driving two antennas to generate electromagnetic fields from the left and right sides of the brain, and by modulating the sleep excitation zone of the brain, so as to increase the excitement, so that the brain normally shifts from the awake mode to the sleep mode. Achieve sleep aid.
  • Figure 11 shows a sleep aid hardware system of the present invention.
  • Figure 12 shows a pillow type sleep aid of the present invention.
  • Figure 13 shows a bedside/pillow sleep aid of the present invention.
  • Figure 14 shows a forehead type sleep aid of the present invention.
  • Figure 15 shows a sitting/horizontal sleep aid of the present invention.
  • Figure 16 shows a sleep management system of the present invention.
  • Figure 17 shows the hardware system of a sleep management system of the present invention.
  • Figure 18 is a schematic diagram of a sleep management system in accordance with another example of the present invention.
  • Fig. 19 is a hardware system diagram showing the sleep management system of another example of the present invention shown in Fig. 18.
  • the wake-up excitatory zone 4 suppresses the sleep excitatory zone 3 through the channel 5, and simultaneously inhibits the thalamic reticular nucleus 2 through the channel 6, at which time the sleep hormone is not released.
  • brain 1 is transformed from awakened mode to sleep mode, and sleep excitatory zone 3 enhances excitement, inhibiting wakefulness and excitement zone 4 through channel 7, so that wakefulness zone 4 passes through channel 6 to thalamic reticular nucleus.
  • the inhibition of excitement of 2 is weakened.
  • the sleep excitatory zone 3 continues to increase the excitement, inhibiting the excitement of the rejuvenation zone 4, and causing the rejuvenation zone 4 to stimulate the excitability of the thalamic reticular nucleus 2
  • the thalamic reticular nucleus 2 releases the sleep hormone through the channel 8 in the whole brain, and the whole brain enters a sleep mode.
  • Fig. 4 shows a method and system of the present invention for helping a brain that does not normally sleep to normally enter a sleep state.
  • the electromagnetic field 9 is applied to the brain 1 to modulate the sleep excitatory zone 3 of the brain 1, so that the excitement of the sleep excitatory zone 3 in an abnormal state is improved, and the arousal excitatory zone 4 is effectively suppressed, thereby causing the awakening excitatory zone 4 to the thalamic reticular
  • the inhibitory channel 6 of the nucleus 2 is blocked, allowing the thalamic reticular nucleus 2 to release the sleep hormone through the channel 8 throughout the brain, thereby allowing the brain 1 to normally enter the sleep mode.
  • Fig. 5 shows another method and system of the present invention for helping a brain that does not normally sleep to normally enter a sleep mode.
  • the pulsed electromagnetic field 10 is applied to the brain 1 to modulate the sleep excitatory zone 3 of the brain 1, so that the excitement of the sleep excitatory zone 3 in an abnormal state is improved, and the arousal excitatory zone 4 is effectively suppressed, thereby further awakening the excited zone 4 to the thalamus network.
  • the inhibitory channel 6 of the nucleus 2 is blocked, causing the thalamic reticular nucleus 2 to release the sleep hormone through the channel 8 throughout the brain, thereby allowing the brain 1 to normally enter the sleep mode.
  • the above electromagnetic field may be any electromagnetic field, including an electromagnetic field of any frequency (the most effective frequency range using the method is 3000 Hz to 300,000,000, 000 Hz), any waveform of electromagnetic field (the most effective waveforms using this method include: sine, square, sawtooth, pulse), any duty cycle pulsed electromagnetic field (the most effective duty cycle using this method is 5 % to 90%) and electromagnetic fields of any strength; also includes naturally occurring electromagnetic fields and artificially generated electromagnetic fields.
  • Fig. 6 shows a sleep assisting method and system of the present invention, which is mainly composed of an antenna 11 and an electromagnetic field driving power source 12.
  • the electromagnetic field driving power source 12 generates an electromagnetic field from the rear of the brain 1 to the brain 1 by driving the antenna 11, and the electromagnetic field modulates the excitation of the sleep excitation zone 3, so that the excitement of the sleep excitation zone 3 in an abnormal state is improved, and the sleep excitation zone is enhanced.
  • the distance of the antenna 11 from the brain 1 is fixed (static) or time-varying (dynamic).
  • Fig. 7 shows another sleep assisting method and system of the present invention, which is mainly composed of an antenna 11 and an electromagnetic field driving power source 12.
  • the electromagnetic field driving power source 12 generates an electromagnetic field from the upper side of the brain 1 to the brain 1 by driving the antenna 11, and the electromagnetic field modulates the excitation of the sleep excitation zone 3, so that the excitement of the sleep excitation zone 3 in an abnormal state is improved, and the sleep excitation zone is enhanced.
  • the rejuvenation zone 4 and then the inhibition channel 6 of the thalamic reticular nucleus 2 is blocked by the resuscitation zone 4, so that the thalamic reticular nucleus 2 releases the sleep hormone through the channel 8 in the whole brain, and the brain 1 normally goes to sleep. mode.
  • Fig. 8 shows another sleep assisting method and system of the present invention, which is mainly composed of an antenna 11 and an electromagnetic field driving power source 12.
  • the electromagnetic field driving power source 12 generates an electromagnetic field from the front of the brain 1 to the brain 1 by driving the antenna 11, and the electromagnetic field modulates the excitation of the sleep excitation zone 3, so that the excitement of the sleep excitation zone 3 in the abnormal state is improved, and the sleep excitation zone is improved.
  • the rejuvenation zone 4 and then the inhibition channel 6 of the thalamic reticular nucleus 2 is blocked by the resuscitation zone 4, so that the thalamic reticular nucleus 2 releases the sleep hormone through the channel 8 in the whole brain, and the brain 1 normally goes to sleep. mode.
  • Fig. 9 shows another sleep assisting method and system of the present invention, which is mainly composed of an antenna 11, an antenna 14, an electromagnetic field driving power source 15, and an electromagnetic field driving power source 12.
  • the electromagnetic field driving power source 12 drives the antenna 11 and the electromagnetic field driving power source 15 drives the antenna 14 to generate an electromagnetic field from the left and right sides of the brain 1 to the brain 1 at the same time or at different times, and the electromagnetic field modulates the excitation of the sleep excitation zone 3 to make the abnormal state
  • the excitement of the sleep excitement zone 3 is enhanced, so that the sleep excitatory zone 3 effectively inhibits the rejuvenation zone 4, and thus the inhibition channel 6 of the thalamic reticular nucleus 2 is blocked, and the thalamic reticular nucleus 2 passes through the channel.
  • 8 Releases sleep hormones throughout the brain, and brain 1 normally enters sleep mode.
  • Fig. 10 shows another sleep aiding method and system of the present invention, which is mainly composed of an antenna 17, an antenna 18, and an electromagnetic field driving power source 16.
  • the electromagnetic field driving power source 16 generates an electromagnetic field from the left and right sides of the brain 1 to the brain 1 at the same time or at different times by driving the antenna 17 and the antenna 18, and the electromagnetic field modulates the excitement of the sleep excitation zone 3 to excite the sleep in an abnormal state.
  • the excitement of Zone 3 is enhanced, so that the sleep excitatory zone 3 effectively inhibits the rejuvenation zone 4, and thus the inhibition channel 6 of the thalamic reticular nucleus 2 is blocked by the resuscitation zone 4, and the thalamic reticular nucleus 2 passes through the channel 8 in the whole brain.
  • the brain 1 normally enters a sleep mode.
  • FIG. 11 shows a hardware system of the sleep aid of the present invention, mainly composed of a signal source 19, a first-stage power amplifier module 20, a secondary power amplifier module 21, a drive power module 22, a microcontroller 23, a voltage regulator source module 24, and a battery 25.
  • the charging module 26 and the antenna 27 are composed.
  • the signal source 19 emits a high frequency electrical signal, which is amplified by the primary power amplifier module 20, then amplified by the secondary power amplifier module 21, and then input to the antenna 27, which generates the desired sleep excitation zone 3 of the brain. Electromagnetic field.
  • Figure 12 shows a pillow-type sleep aid of the present invention, which is mainly composed of a pillow 28 and a sleep aid body 30 (including a sleep aid switch 29).
  • the sleep aid body 30 is placed in the pillow 28, and in use, the sleep aid switch 29 is pressed to normally turn on the sleep aid, and the pillow type sleep aid generates an electromagnetic field to modulate the sleep excitation zone 3 of the brain. Increased their excitement, causing Brain 1 to enter sleep mode normally.
  • FIG. 13 shows a bedside/pillow sleep aid of the present invention, which is mainly composed of a structural frame 31 and a sleep aid body 32.
  • the structural frame 31 is rotatably coupled to the sleep aid body 32.
  • the bedside/pillow sleep aid comprises two uses: 1 rotating the sleeper body 32 relative to the structural frame 31, forming an angle of approximately 90° with the structural frame 31, and placing the structural frame 31 under the pillow.
  • the body 32 is at an angle of 90° to the bed surface.
  • the sleep aid body 32 When the switch of the bedside/pillow sleeper is turned on, the sleep aid body 32 generates an electromagnetic field from the top of the head to the sleep excitation zone 3 of the brain 1 to modulate the brain.
  • Sleep excitement area 3 increase its excitement, causing the brain 1 to enter the sleep mode normally; 2 close the sleep aid body 32 and the structural frame 31, and place it under the pillow, when the bedside/pillow type sleeper switch When turned on, the sleep aid body 32 generates an electromagnetic field from the back of the head to the sleep excitatory zone 3 of the brain 1 to modulate the sleep excitatory zone 3 of the brain, thereby increasing its excitement, causing the brain 1 to normally enter the sleep mode.
  • Figure 14 shows a forehead type sleep aid of the present invention, which is mainly composed of a structural frame 35 and a sleep aid body 34.
  • the person lies on the bed 33, adjusts the structural frame 35, so that the sleep aid body 34 is located just above the brain 1.
  • the sleep aid body 34 is from the forebrain to the brain 1
  • the sleep excitatory zone 3 generates an electromagnetic field to modulate the sleep excitatory zone 3 of the brain, increasing its excitement, causing the brain 1 to normally enter a sleep mode.
  • the structural frame 35 mainly has the following functions: 1 supporting the body 34 and making the body 34 properly fit the forehead of the head during use to achieve the most effective generation of the electromagnetic field and acting on the sleep excitation zone of the brain 1; 2 adjusting the body 34 The location is convenient for use; 3 is fixed anywhere on the bed, bedside or bedroom.
  • Figure 15 shows a sitting/horizontal sleep aid of the present invention, which is mainly composed of a multi-function structure frame 36 and a sleep aid body 37.
  • the multi-function structure frame 36 is adjusted, and the sleeper body 37 is placed at the top of the brain 1.
  • the sleep aid body 37 From the top of the brain 1 to the sleep excitatory zone 3 of the brain 1 to generate an electromagnetic field to modulate the sleep excitatory zone 3 of the brain, to increase its excitement, causing the brain 1 to normally enter a sleep mode; when used for horizontal, adjust the multi-function structure 36.
  • the sleep aid body 37 is placed above the forebrain.
  • the sleep aid body 37 When the sitting/horizontal sleeper is turned on, the sleep aid body 37 generates an electromagnetic field from the forebrain to the sleep excitatory region 3 of the brain 1 to modulate the brain.
  • the sleep excitement zone 3 raising its excitement, causes the brain 1 to normally enter a sleep mode.
  • Figure 16 shows a sleep management system of the present invention, mainly composed of a sleep aid 39 and a sleep depth monitor 41.
  • the sleep depth monitor 41 detects the sleep depth of the brain 1 by detecting the degree to which the blue plaque 13 of the brain 1 is suppressed in the sleep excitatory region 3 of the brain 1 by the direct detection method or the indirect detection method.
  • the sleep depth of brain 1 refers to the measure of the degree of sleep in the process of transitioning from the awake mode to the deep sleep mode of the brain 1, and is expressed by the percentage reduction of the excitation region 13 of the blue plaque to reduce the excitability, thereby dividing the sleep depth into Several levels.
  • the sleep depth monitor 41 transmits a signal to the sleep aid 39 via the antenna 40 to turn on the sleep aid 39.
  • the sleep aid 39 automatically Turn on, generate an electromagnetic field to the brain 1 to modulate the sleep excitation zone 3 of the brain, increase its excitement, and cause the brain 1 to normally enter the sleep mode until the sleep depth monitor 41 detects that the sleep depth is above a critical value, the sleep depth monitor 41, the antenna 40 transmits a signal for turning off the sleep aid 39 to the sleep aid 39.
  • the sleep aid 39 automatically turns off, and the sleep aid 39 no longer generates an electromagnetic field to the brain 1. Until the antenna 38 receives the next turn-on signal.
  • FIG 17 shows a hardware system of the sleep management system shown in Figure 16 of the present invention.
  • the sleep aid body including: signal source 19, primary power amplifier module 20, secondary power amplifier module 21, drive power supply module 22, microcontroller 23, voltage regulator source module 24, battery 25, charging module 26, antenna 27
  • a sleep depth monitor including: a control system 44 for the sleep aid, a monitoring system 45, an operation display system 47, an antenna 48.
  • the operation display system 47 of the sleep depth monitor receives the input sleep management parameter manipulation monitoring system 45 to detect the sleep depth.
  • the control system 44 assists the antenna 48 through the antenna 48.
  • the device sends an enable signal, and after receiving the signal, the receiving module 42 sends the information to the microcontroller 23, and the microcontroller 23 sends a signal for turning on the sleep aid, and the signal source 19 sends a high-frequency electrical signal through the first-stage power amplifier.
  • Module 20 is amplified and then amplified by secondary power amplifier module 21 and then input to antenna 27, which produces the desired electromagnetic field of the sleep excitation zone 3 of the modulated brain.
  • the control system 44 sends a shutdown signal to the sleep aid via the antenna 48.
  • the receiving module 42 sends the information to the microcontroller 23, by the microcontroller. 23 Turn off the sleep aid.
  • the sleep depth monitor's monitoring system 45 is always in the monitoring control state until the sleep time reaches the input parameter requirements.
  • Figure 18 shows another sleep management system of the present invention, which is mainly composed of an antenna 48, an antenna 49, a sleep aid 50, and a sleep depth monitor 51.
  • the sleep depth monitor 51 detects the sleep depth of the brain 1 by detecting the degree to which the blue plaque 13 of the brain 1 is suppressed in the sleep excitatory region 3 of the brain 1 by the direct detection method or the indirect detection method.
  • the sleep depth of brain 1 refers to the measure of the degree of sleep in the process of transitioning from the awake state to the sleeping state of the brain 1, and is expressed by the percentage reduction of the excitation region 13 of the nucleus nucleus to reduce the excitement, thereby dividing the depth of sleep into Several levels.
  • the sleep depth monitor 51 When the sleep depth monitor 51 detects that the sleep depth is lower than a threshold by the antenna 49, the sleep depth monitor 51 sends a signal to the sleep aid 50 to turn on the sleep aid 50, and after receiving the turn-on signal, the sleeper 50 receives the turn-on signal. It will automatically turn on, generate an electromagnetic field to the brain 1 through the antenna 48 to modulate the sleep excitation zone 3 of the brain, increase its excitement, and cause the brain 1 to normally enter the sleep mode until the sleep depth monitor 51 detects that the sleep depth is higher than one through the antenna 49. At the critical value, the sleep depth monitor 51 transmits a signal to the sleep aid 50 to turn off the sleep aid 50. After receiving the shutdown signal, the sleep aid 50 automatically turns off, and the sleep aid 50 no longer passes through the antenna 48. An electromagnetic field is generated to the brain 1 until the sleeper 50 receives the next turn-on signal.
  • FIG. 19 shows another hardware system of the sleep management system shown in FIG. 18 of the present invention, mainly composed of a sleep aid body (including: antenna 69, antenna 68, circulator 62, amplifier 63, power divider 61, mixing) 64, signal source 60, voltage regulator source 59, low-pass filter 65, first-stage power amplifier module 53, second-stage power amplifier module 52, drive power module 55, microcontroller 57, voltage regulator source module 58, signal source 54, The battery 66, the charging module 67 and the human-machine interaction module 56) are composed.
  • the signal source 60 sends an electrical signal, a part of the electrical signal is input to the mixer 64 via the power divider 61, and the other portion is input to the antenna 68 via the circulator 62.
  • An electromagnetic field is generated by the antenna 68 to act on the brain 1, also by the antenna.
  • 68 receives the electromagnetic field passing through the brain 1 and passes through the circulator 62, and then is amplified by the amplifier 63, and then input to the mixer 64.
  • the mixer 64 compares the electric signal input by the splitter 61 with the electric signal input by the amplifier 63. A difference is formed, and the difference is transmitted to the low-pass filter 65 for filtering, and then input to the microcontroller 57.
  • the microcontroller determines the difference according to the sleep parameter received by the human-machine interaction module 56, and determines whether to turn on or shut down.
  • the microcontroller 57 issues an on signal, and the high frequency electrical signal is sent by the signal source 54 to be amplified by the first stage power amplifier module 53, and then amplified by the secondary power amplifier module 52, and then input.
  • the antenna 69 by the antenna 69, generates the electromagnetic field of the sleep excitation zone 3 required to modulate the brain.
  • the microcontroller 57 issues a shutdown signal. During the entire sleep process, the sleep management system automatically shuts down until the sleep time reaches the entered parameter requirement.
  • the antenna 68 may be one antenna or two or more antennas (transmitting antenna and receiving antenna).
  • Another method and system of the present invention is a sleep treatment method and system for treating a number of major diseases, including Alzheimer's disease, cancer, using a sleep management system as shown in Figures 16, 17, 18, and 19. And depression.
  • the operating parameters of the sleep management system are determined and input according to the disease being treated.
  • the sleep depth monitor automatically controls to turn on the sleep aid to modulate the brain's sleep excitation zone so that the patient's brain enters and The deep sleep mode is maintained until the sleep depth indicator and the deep sleep time indicator specified by the sleep are completed, thereby achieving the effect of treating the disease.

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Abstract

一个用电磁场调制脑的睡眠兴奋区（3）使脑从醒的模式转入睡眠模式的系统，包括助眠仪，助眠仪利用或产生电磁场（9，10）作用在脑的睡眠兴奋区（3），促使睡眠兴奋区（3）提高兴奋，从而抑制脑的苏醒兴奋区（4），进而通过抑制脑的苏醒兴奋区（4）以阻隔脑的苏醒兴奋区（4）对丘脑网状核（2）的抑制作用，促使丘脑网状核（2）向全脑释放睡眠荷尔蒙，使全脑正常地进入睡眠模式；由所述助眠仪和睡眠深度监测仪组成睡眠管理系统和睡眠治疗系统，控制睡眠的深度和时间以管理睡眠和通过管理睡眠治疗疾病。

Description

用电磁场调制脑睡眠兴奋区的方法和仪器
【技术领域】
本发明提供用电磁场调制脑睡眠兴奋区以实现助眠、睡眠管理和睡眠治疗的方法和仪器。
【背景技术】
入眠障碍是现代人们生活中一个亟待解决的问题。目前，解决入眠障碍的常见方法主要是药物法，药物法的主要问题是会产生各种副作用，如：导致人逐步丧失记忆力、食欲减退、性欲减退、损害人体内脏器官、产生依赖性、神经错乱。
【发明内容】
脑有多个功能兴奋区。其中有苏醒兴奋区（含：蓝斑核LC、盖背外侧核LDT、脚桥核PPT）、睡眠兴奋区(含：腹外侧视前区VLPO)、丘脑网状核TRN。在脑处于醒的状态时，苏醒兴奋区抑制着睡眠兴奋区和丘脑网状核，抑制的结果是睡眠荷尔蒙在全脑不被释放，以保持脑处于醒的状态。在脑从醒的状态转化到睡眠状态的过程中，睡眠兴奋区提高兴奋，抑制苏醒兴奋区的兴奋，从而使苏醒兴奋区对丘脑网状核的抑制减弱直至趋于零。当脑的苏醒兴奋区对丘脑网状核的兴奋的抑制趋于零/被阻隔，丘脑网状核就向全脑释放睡眠荷尔蒙，此时，脑进入睡眠状态。有入睡困难的人，由于脑内多种神经递质不能正常协調，在入睡过程中睡眠兴奋区不能正常地提高兴奋，以致无法正常入睡。
本发明提供用电磁场调制脑的睡眠兴奋区以帮助脑进入睡眠、管理睡眠和通过睡眠治疗疾病的方法和仪器。
在本发明中，对脑的助眠是通过产生一个电磁场，调制脑的睡眠兴奋区，使其提高兴奋，以致脑正常地从醒的模式转入睡眠模式来实现的。
在本发明中，对脑的睡眠管理是通过一个用电磁场调制脑的睡眠兴奋区，使其提高兴奋，以致脑正常地从醒的模式转入睡眠模式的助眠仪和一个睡眠深度监测仪来实现的，其中，睡眠深度监测仪检测脑的睡眠深度并控制助眠仪的开启和关闭以调控脑的睡眠深度和持续睡眠时间,达到设定的脑的连续深度睡眠时间的指标。
在本发明中，睡眠治疗是用本发明的睡眠管理方法和系统来实现的。其中，睡眠管理系统包括用电磁场调制脑的睡眠兴奋区，使其提高兴奋，以致脑正常地从醒的模式转入睡眠模式的助眠仪和一个睡眠深度监测仪；睡眠深度监测仪接受治疗指定疾病的睡眠参数（包括睡眠深度和睡眠时间）并控制助眠仪确保睡眠按照指定的睡眠参数完成。
【附图说明】
图1显示脑的与本发明相关的三个兴奋区：苏醒兴奋区（含：蓝斑核LC、盖背外侧核LDT、脚桥核PPT）、睡眠兴奋区(含：腹外侧视前区VLPO)、丘脑网状核TRN，在脑处于醒的模式下的相互关系。
图2显示脑的与本发明相关的三个兴奋区：苏醒兴奋区（含：蓝斑核LC、盖背外侧核LDT、脚桥核PPT）、睡眠兴奋区(含：腹外侧视前区VLPO)、丘脑网状核TRN，在脑由醒的状态转化到睡眠模式下的相互关系。
图3显示脑的与本发明相关的三个兴奋区：苏醒兴奋区（含：蓝斑核LC、盖背外侧核LDT、脚桥核PPT）、睡眠兴奋区(含：腹外侧视前区VLPO)、丘脑网状核TRN，在脑处于睡眠模式下的相互关系。
图4显示本发明的用电磁场调制脑的睡眠兴奋区，使其提高兴奋，以致脑正常地从醒的模式转入睡眠模式来实现助眠。
图5显示本发明的用脉冲电磁场调制脑的睡眠兴奋区，使其提高兴奋，以致脑正常地从醒的模式转入睡眠模式来实现助眠。
图6显示本发明的从脑的后方对脑产生电磁场，通过调制脑的睡眠兴奋区，使其提高兴奋，以致脑正常地从醒的模式转入睡眠模式来实现助眠。
图7显示本发明的从脑的上方对脑产生电磁场，通过调制脑的睡眠兴奋区，使其提高兴奋，以致脑正常地从醒的模式转入睡眠模式来实现助眠。
图8显示本发明的从脑的前方对脑产生电磁场，通过调制脑的睡眠兴奋区，使其提高兴奋，以致脑正常地从醒的模式转入睡眠模式来实现助眠。
图9显示本发明的两个电磁场驱动电源各自驱动一个天线从脑的左右两侧产生两个电磁场，通过调制脑的睡眠兴奋区，使其提高兴奋，以致脑正常地从醒的模式转入睡眠模式来实现助眠。
图10显示本发明的一个电磁场驱动电源驱动两个天线从脑的左右两侧各自产生电磁场，通过调制脑的睡眠兴奋区，使其提高兴奋，以致脑正常地从醒的模式转入睡眠模式来实现助眠。
图11显示本发明的一个助眠仪硬件系统。
图12显示本发明的一个枕头式助眠仪。
图13显示本发明的一个床头式/枕头式助眠仪。
图14显示本发明的一个额头式助眠仪。
图15显示本发明的一个坐式/卧式助眠仪。
图16显示本发明的一个睡眠管理系统。
图17显示本发明的一个睡眠管理系统的硬件系统。
图18是关于本发明中的另一例的睡眠管理系统的示意图。
图19是显示图18所显示的关于本发明中的另一例的睡眠管理系统的硬件系统图。
【具体实施方式】
如图1所示，脑1在醒的模式下，苏醒兴奋区4通过渠道5抑制着睡眠兴奋区3，并同时通过渠道6抑制着丘脑网状核2，此时睡眠荷尔蒙不释放。
如图2所示，脑1由醒的模式转化到睡眠模式的过程中，睡眠兴奋区3提高兴奋，通过渠道7抑制苏醒兴奋区4，从而使苏醒兴奋区4通过渠道6对丘脑网状核2的兴奋的抑制减弱。
如图3所示，脑1在进入睡眠模式的过程中，睡眠兴奋区3持续提高兴奋，抑制苏醒兴奋区4的兴奋，致使苏醒兴奋区4对丘脑网状核2的兴奋的抑制渠道6被阻隔，此时，丘脑网状核2通过渠道8在全脑释放睡眠荷尔蒙，使全脑进入睡眠模式。
以上所描述的是当脑1正常地由醒的模式进入睡眠模式的过程。而在非正常的状态下，如入睡有困难的状态下，睡眠兴奋区3不能正常地提高兴奋，无法有效地抑制苏醒兴奋区4，致使苏醒兴奋区4对丘脑网状核2的抑制保持，丘脑网状核2无法在全脑释放睡眠荷尔蒙，因此脑1无法正常地进入睡眠模式。
图4显示本发明的一种帮助不能正常入眠的脑正常地进入睡眠状态的方法和系统。将电磁场9施加在脑1上，调制脑1的睡眠兴奋区3，使非正常状态下的睡眠兴奋区3的兴奋提高，有效地抑制苏醒兴奋区4，进而使苏醒兴奋区4对丘脑网状核2的抑制渠道6被阻隔，使丘脑网状核2通过渠道8在全脑释放睡眠荷尔蒙，从而使脑1正常地进入睡眠模式。
图5显示本发明的另一种帮助不能正常入眠的脑正常地进入睡眠模式的方法和系统。将脉冲电磁场10施加在脑1上，调制脑1的睡眠兴奋区3，使非正常状态下的睡眠兴奋区3的兴奋提高，有效地抑制苏醒兴奋区4，进而使苏醒兴奋区4对丘脑网状核2的抑制渠道6被阻隔，使丘脑网状核2通过渠道8在全脑释放睡眠荷尔蒙，从而使脑1正常地进入睡眠模式。
上述电磁场可以是任何电磁场，包括任何频率的电磁场（使用本方法最有效的频率范围是3000Hz到300,000,000, 000Hz的）、任何波形的电磁场（使用本方法最有效的波形包括：正弦波、方波、锯齿波、脉冲波）、任何占空比的脉冲电磁场（使用本方法最有效的占空比是5%至90%）和任何强度的电磁场；也包括天然存在的电磁场和人为产生的电磁场。
图6显示本发明的一个助眠方法和系统，主要由天线11、电磁场驱动电源12组成。其中，电磁场驱动电源12通过驱动天线11从脑1的后方对脑1产生一个电磁场，该电磁场调制睡眠兴奋区3的兴奋，使非正常状态下的睡眠兴奋区3的兴奋提高，使睡眠兴奋区3有效地抑制苏醒兴奋区4，进而使苏醒兴奋区4对丘脑网状核2的抑制渠道6被阻隔，使丘脑网状核2通过渠道8在全脑释放睡眠荷尔蒙，脑1正常地进入睡眠模式。在本发明中，天线11与脑1的距离是固定的（静态）或随时间变化的（动态）。
图7显示本发明的另一个助眠方法和系统，主要由天线11、电磁场驱动电源12组成。其中，电磁场驱动电源12通过驱动天线11从脑1的上方对脑1产生一个电磁场，该电磁场调制睡眠兴奋区3的兴奋，使非正常状态下的睡眠兴奋区3的兴奋提高，使睡眠兴奋区3有效地抑制苏醒兴奋区4，进而使苏醒兴奋区4对丘脑网状核2的抑制渠道6被阻隔，使丘脑网状核2通过渠道8在全脑释放睡眠荷尔蒙，脑1正常地进入睡眠模式。
图8显示本发明的另一个助眠方法和系统，主要由天线11、电磁场驱动电源12组成。其中，电磁场驱动电源12通过驱动天线11从脑1的前方对脑1产生一个电磁场，该电磁场调制睡眠兴奋区3的兴奋，使非正常状态下的睡眠兴奋区3的兴奋提高，使睡眠兴奋区3有效地抑制苏醒兴奋区4，进而使苏醒兴奋区4对丘脑网状核2的抑制渠道6被阻隔，使丘脑网状核2通过渠道8在全脑释放睡眠荷尔蒙，脑1正常地进入睡眠模式。
图9显示本发明的另一个助眠方法和系统，主要由天线11、天线14、电磁场驱动电源15和电磁场驱动电源12组成。其中，电磁场驱动电源12驱动天线11、电磁场驱动电源15驱动天线14分别从脑1的左右两侧对脑1同时或不同时产生一个电磁场，该电磁场调制睡眠兴奋区3的兴奋，使非正常状态下的睡眠兴奋区3的兴奋提高，使睡眠兴奋区3有效地抑制苏醒兴奋区4，进而使苏醒兴奋区4对丘脑网状核2的抑制渠道6被阻隔，使丘脑网状核2通过渠道8在全脑释放睡眠荷尔蒙，脑1正常地进入睡眠模式。
图10显示本发明的另一个助眠方法和系统，主要由天线17、天线18和电磁场驱动电源16组成。其中，电磁场驱动电源16通过驱动天线17和天线18分别从脑1的左右两侧对脑1同时或不同时产生一个电磁场，该电磁场调制睡眠兴奋区3的兴奋，使非正常状态下的睡眠兴奋区3的兴奋提高，使睡眠兴奋区3有效地抑制苏醒兴奋区4，进而使苏醒兴奋区4对丘脑网状核2的抑制渠道6被阻隔，使丘脑网状核2通过渠道8在全脑释放睡眠荷尔蒙，脑1正常地进入睡眠模式。
图11显示本发明的助眠仪的一个硬件系统，主要由信号源19、一级功放模块20、二级功放模块21、驱动电源模块22、微控制器23、稳压源模块24、电池25、充电模块26、天线27组成。该系统中，信号源19发出高频电信号，通过一级功放模块20放大，然后通过二级功放模块21放大，然后输入天线27，由天线27产生所需要的调制脑的睡眠兴奋区3的电磁场。
图12显示本发明的一个枕头式助眠仪，主要由枕头28、助眠仪机体30（含助眠仪开关29）组成。助眠仪机体30被放置在枕头28内，在使用时，将助眠仪开关29按下以正常开启助眠仪，这时该枕头式助眠仪产生电磁场以调制脑的睡眠兴奋区3，提高其兴奋，致使脑1正常地进入睡眠模式。
图13显示本发明的一个床头式/枕头式助眠仪，主要由结构架31、助眠仪机体32组成，结构架31与助眠仪机体32是转动连接的。该床头式/枕头式助眠仪包含两种用法：①将助眠仪机体32相对结构架31转动，与结构架31形成接近90°的夹角，将结构架31放置在枕头下，这时机体32与床面呈90°夹角，当该床头式/枕头式助眠仪的开关被开启时，助眠仪机体32从头顶向脑1的睡眠兴奋区3产生电磁场以调制脑的睡眠兴奋区3，提高其兴奋，致使脑1正常地进入睡眠模式；②将助眠仪机体32与结构架31合上，放置在枕头下，当该床头式/枕头式助眠仪的开关被开启时，助眠仪机体32从后脑勺向脑1的睡眠兴奋区3产生电磁场以调制脑的睡眠兴奋区3，提高其兴奋，致使脑1正常地进入睡眠模式。
图14显示本发明的一个额头式助眠仪，主要由结构架35、助眠仪机体34组成。使用时，人躺在床33上，调节结构架35，使助眠仪机体34恰好位于脑1的上方，当该额头式助眠仪被开启时，助眠仪机体34从前脑向脑1的睡眠兴奋区3产生电磁场以调制脑的睡眠兴奋区3，提高其兴奋，致使脑1正常地进入睡眠模式。该结构架35主要有以下功能：①扶持机体34并使机体34在使用时恰当吻合头的前额以实现最有效地产生所述电磁场并将其作用于脑1的睡眠兴奋区；②调节机体34的位置以方便使用；③固定在床上、床头或卧室里的任何位置。
图15显示本发明的一个坐式/卧式助眠仪，主要由多功位结构架36、助眠仪机体37组成。当用于坐式时，调节多功位结构架36，将助眠仪机体37置放于脑1的顶端，当该坐式/卧式助眠仪的开关被开启时，助眠仪机体37从脑1的顶端向脑1的睡眠兴奋区3产生电磁场以调制脑的睡眠兴奋区3，提高其兴奋，致使脑1正常地进入睡眠模式；当用于卧式时，调节多功位结构架36，将助眠仪机体37置放于前脑的上方，当该坐式/卧式助眠仪被开启时，助眠仪机体37从前脑向脑1的睡眠兴奋区3产生电磁场以调制脑的睡眠兴奋区3，提高其兴奋，致使脑1正常地进入睡眠模式。
图16显示本发明的一个睡眠管理系统，主要由助眠仪39和睡眠深度监测仪41组成。该系统中，睡眠深度监测仪41用直接检测法或间接检测法通过检测脑1的蓝斑核13在脑1的睡眠兴奋区3提高兴奋时的被抑制的程度来检测脑1的睡眠深度。脑1的睡眠深度是指对脑1从醒的模式转变到熟睡模式的过程中睡眠程度的度量，用蓝斑核兴奋区13被抑制从而降低兴奋的降低百分比表示，因而可将睡眠深度分为若干级。当睡眠深度被测到低于一个临界值时，睡眠深度监测仪41通过天线40向助眠仪39发射开启助眠仪39的信号，天线38接收到该开启信号后，助眠仪39会自动开启，对脑1产生电磁场以调制脑的睡眠兴奋区3，提高其兴奋，致使脑1正常地进入睡眠模式，直到睡眠深度监测仪41监测到睡眠深度高于一个临界值时，睡眠深度监测仪41又通过天线40向助眠仪39发射关闭助眠仪39的信号，天线38接收到该关闭信号后，助眠仪39会自动关闭，此时助眠仪39不再对脑1产生电磁场，直到天线38接收到下一个开启信号。
图17显示本发明的一个如图16所示的睡眠管理系统的硬件系统。主要由助眠仪机体（含：信号源19、一级功放模块20、二级功放模块21、驱动电源模块22、微控制器23、稳压源模块24、电池25、充电模块26、天线27)和睡眠深度监测仪（含：对助眠仪的控制系统44、监测系统45、操作显示系统47、天线48）组成。该系统中，睡眠深度监测仪的操作显示系统47接收输入的睡眠管理参数操纵监测系统45以检测睡眠深度，当睡眠深度被检测到低于一个临界值时，控制系统44通过天线48向助眠仪发送开启信号，接收模块42接收到该信号后，将信息传入微控制器23，由微控制器23发出开启助眠仪的信号，由信号源19发出高频电信号，通过一级功放模块20放大，然后通过二级功放模块21放大，然后输入天线27，由天线27产生所需要的调制脑的睡眠兴奋区3的电磁场。而当睡眠深度被检测到高于一个临界值时，控制系统44通过天线48向助眠仪发送关闭信号，接收模块42接收到该信号后，将信息传入微控制器23，由微控制器23关闭助眠仪。在整个睡眠过程中，睡眠深度监测仪的监测系统45一直处于监测控制状态，直到睡眠时间达到所输入的参数要求才自动关闭。
图18显示本发明的另一个睡眠管理系统，主要由天线48、天线49、助眠仪50、睡眠深度监测仪51组成。该系统中，睡眠深度监测仪51用直接检测法或间接检测法通过检测脑1的蓝斑核13在脑1的睡眠兴奋区3提高兴奋时的被抑制的程度来检测脑1的睡眠深度。脑1的睡眠深度是指对脑1从醒的状态转变到熟睡状态的过程中睡眠程度的度量，用蓝斑核兴奋区13被抑制从而降低兴奋的降低百分比表示，因而可将睡眠深度分为若干级。当睡眠深度监测仪51通过天线49检测到睡眠深度低于一个临界值时，睡眠深度监测仪51向助眠仪50发出开启助眠仪50的信号，助眠仪50接收到该开启信号后，会自动开启，通过天线48对脑1产生电磁场以调制脑的睡眠兴奋区3，提高其兴奋，致使脑1正常地进入睡眠模式，直到睡眠深度监测仪51通过天线49检测到睡眠深度高于一个临界值时，睡眠深度监测仪51又向助眠仪50发射关闭助眠仪50的信号，接收到该关闭信号后，助眠仪50会自动关闭，此时助眠仪50不再通过天线48对脑1产生电磁场，直到助眠仪50接收到下一个开启信号。
图19显示本发明的另一个如图18所示的睡眠管理系统的硬件系统，主要由助眠仪机体（含：天线69、天线68、环形器62、放大器63、功分器61、混频器64、信号源60、稳压源59、低通滤波器65、一级功放模块53、二级功放模块52、驱动电源模块55、微控制器57、稳压源模块58、信号源54、电池66、充电模块67和人机交互模块56）组成。该系统中，信号源60发出电信号，经过功分器61将一部分电信号输入混频器64，另一部分经过环形器62输入天线68，由天线68产生一个电磁场作用于脑1，也由天线68接收穿过脑1的电磁场后经过环形器62，然后经过放大器63放大后，输入混频器64，混频器64将由功分器61输入的电信号和由放大器63输入的电信号进行比较形成差值，将该差值传入低通滤波器65过滤后，输入微控制器57，微控制器根据人机交互模块56所接收到的睡眠参数对该差值进行判断，决定是否开启或关闭。当睡眠深度被检测到低于一个临界值时，微控制器57发出开启信号，由信号源54发出高频电信号，通过一级功放模块53放大，然后通过二级功放模块52放大，然后输入天线69，由天线69产生所需要的调制脑的睡眠兴奋区3的电磁场。而当睡眠深度被检测到高于一个临界值时，微控制器57则发出关闭信号。在整个睡眠过程中，该睡眠管理系统直到睡眠时间达到所输入的参数要求才自动关闭。在本系统中，天线68可以是一个天线，也可以是两个或多个天线（发射天线和接收天线）。
本发明的另一个方法和系统是睡眠治疗方法和系统，该方法和系统用如图16、图17、图18、图19所示的睡眠管理系统治疗若干重大疾病，包括：老年痴呆症、癌症和忧郁症。在此方法中，睡眠管理系统的操作参数是按被治疗的疾病决定和输入的，当治疗参数输入后，睡眠深度监测仪自动控制开启助眠仪调制脑的睡眠兴奋区使病人的脑进入和保持在深度睡眠模式，直到睡眠完成所指定的睡眠深度指标和深度睡眠时间指标，由此达到治疗疾病的效果。
上述的实施例中的各项技术的特征是符合任何场合任何条件的。为了说明简洁，虽然没有对上述实施例中的各项技术特征的所有的组合进行说明，但只要与这些技术的特征组合不矛盾，必须应该理解为都被包括在说明内，必须应该理解为所有特征都在本说明书和权利要求书的记载范围内。
上述的实施例仅仅是关于本发明的几种形式的实施形式，更有具体地叙述，不过，绝对不限制本发明的保护范围。如果是本发明的技术领域的一般的技术者，只要不脱离本发明的技术思维范围，可以做一些变更和改善，改进。这必须应该理解为全属于本发明的保护范围。本发明的保护范围是根据专利申请的规范所规定的。

Claims (18)

  1. 一个用电磁场调制脑的睡眠兴奋区（含：腹外侧视前区VLPO）以使脑从醒的模式转入睡眠状态的方法，包括利用或产生电磁场作用在脑的睡眠兴奋区，促使睡眠兴奋区提高兴奋，从而抑制脑的苏醒兴奋区（含：蓝斑核LC、盖背外侧核LDT、脚桥核PPT），进而通过抑制脑的苏醒兴奋区阻隔脑的苏醒兴奋区对丘脑网状核的抑制作用，促使丘脑网状核向全脑各兴奋区释放睡眠荷尔蒙，使脑从醒的状态转入睡眠模式。
  2. 在权利要求1中，电磁场是任何电磁场，包括任何频率的电磁场、任何波形的电磁场、任何占空比的脉冲电磁场、任何具有调制频率的电磁场和任何强度的电磁场；也包括天然存在的电磁场和人为产生的电磁场。
  3. 在权利要求1中，睡眠兴奋区提高兴奋包括其兴奋频率的提高和兴奋强度的增强。
  4. 在权利要求1中，电磁场作用于脑的睡眠兴奋区是动态作用或静态作用；电磁场作用于脑的睡眠兴奋区的方向和位置主要包括从后脑往脑的睡眠兴奋区、从头顶往脑的睡眠兴奋区、从头的前方往脑的睡眠兴奋区、从头的左侧或右侧或左右两侧同时往脑的睡眠兴奋区，或上述方位的任意组合同时或不同时往脑的睡眠兴奋区。
  5. 在权利要求1中，所利用或产生的作用在脑的睡眠兴奋区促使睡眠兴奋区提高兴奋从而使脑正常地从醒的模式转入睡眠模式的电磁场是一个或多个电磁场。
  6. 在权利要求1中，用电磁场调高脑的睡眠兴奋区的兴奋使脑从醒的模式转入睡眠模式也包括一个睡眠管理方法，主要含：①按睡眠效果要求/指标设定连续深度睡眠时间长度；②检测脑的睡眠深度；③根据所设定的连续深度睡眠时间长度和所测量到的睡眠深度决定开启或关闭助眠仪的产生和发射电磁场的提高脑的睡眠兴奋区的兴奋的功能；④实施开启或关闭助眠仪使脑的连续深度睡眠时间达到目标。
  7. 在权利要求6中，脑的睡眠深度是指对脑从醒的模式转变到熟睡模式的过程中睡眠程度的度量，用蓝斑核兴奋区被抑制从而降低兴奋的降低百分比表示，将睡眠深度分为若干级。
  8. 在权利要求6中，测量脑的睡眠深度是用检测脑的蓝斑核被脑的睡眠兴奋区提高兴奋区时的抑制的程度来实现的。
  9. 在权利要求6中，根据所设定的连续深度睡眠时间长度和所测量到的睡眠深度决定开启或关闭助眠仪用到一个睡眠深度的临界值；当睡眠深度低于此临界值时，开启助眠仪，而当睡眠深度高于此临界值时，关闭助眠仪；该临界值根据睡眠效果要求设定。
  10. 在权利要求1中，用电磁场调高脑的睡眠兴奋区的兴奋使脑从醒的模式转入睡眠模式，也包括一个睡眠治疗方法，通过管理睡眠治疗若干重大疾病，包括治疗老年痴呆症、癌症和忧郁症，主要是通过控制睡眠深度和深度睡眠时间的增加来实现治疗。
  11. 一个用电磁场调制脑的睡眠兴奋区以使脑从醒的状态转入睡眠状态的系统，包括一个助眠仪，主要由一个或多个电磁场的产生和发射系统组成，用以调制脑的睡眠兴奋区的兴奋，使脑正常地从醒的模式转入睡眠模式。
  12. 在权利要求11中，助眠仪主要由产生所述电磁场的不同大小、不同外形的机体和扶持该机体的结构架组成，该机体包括天线、一级或多级功放模块、信号源、驱动电源模块、稳压源模块、微控制器、充电模块、电池、接收模块、外壳，该结构架主要包括卧式结构架（含：床头式、枕头式、额头式）和坐式结构架。
  13. 在权利要求12中，床头式助眠仪主要由所述机体和可折叠的支架组成，使该仪器在打开时作为床头式助眠仪使用，放置在床头与枕头之间对着入睡者头顶，并产生调制脑的睡眠兴奋区的电磁场，而在合上时可以被放置在枕头底下作为枕头式助眠仪使用。
  14. 在权利要求12中，枕头式助眠仪主要由所述机体和任何枕头组成，可以是将该机体安置在枕头内，也可以是将该机体放置在枕头下。
  15. 在权利要求12中，额头式助眠仪主要由所述机体和固定在床头的扶持该机体的结构架组成；该结构架主要有以下功能：①扶持机体并使机体在使用时恰当吻合头的前额以实现最有效地产生和发射所述电磁场来调高脑的睡眠兴奋区的兴奋；②调节机体的位置以方便使用；③固定在床上、床头或卧室里的任何位置。
  16. 在权利要求12中，坐式助眠仪中所述结构架为多功位支架，其中，多功位支架是可调节的，当调到其坐式功位，该助眠仪可助使用者坐着入睡；当调到其躺睡功位时，该助眠仪可助使用者正常的躺在床上把头枕在自己日常用的枕头上入睡。
  17. 在权利要求11中，还包括一个睡眠管理系统，主要由所述助眠仪和睡眠深度监测仪组成，其中，睡眠深度监测仪测量脑的睡眠深度并根据测到的睡眠深度值控制助眠仪开启或关闭；助眠仪在接收到睡眠深度监测仪发出的开启指令后开启，产生电磁场调高脑的睡眠兴奋区的兴奋使脑进入睡眠模式，并在接收到睡眠深度监测仪发出的关闭指令后停止产生电磁场。
  18. 在权利要求11中，还包括一个睡眠治疗系统，主要由所述助眠仪和睡眠深度监测仪组成，其中，睡眠深度监测仪主要由一个睡眠深度监测系统、一个对助眠仪的控制系统和一个主要用于调控睡眠深度和深度睡眠时间的操作显示系统组成。
PCT/CN2016/104530 2015-11-04 2016-11-04 用电磁场调制脑睡眠兴奋区的方法和仪器 WO2017076320A1 (zh)

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