WO2017038655A1 - Dispositif d'irradiation de lumière biocompatible, procédé d'utilisation d'un dispositif d'irradiation de lumière biocompatible, corps d'étanchéité pour dispositif d'irradiation de lumière biocompatible, procédé de production de corps d'étanchéité pour dispositif d'irradiation de lumière biocompatible, procédé d'utilisation d'un corps d'étanchéité pour dispositif d'irradiation de lumière biocompatible, ensemble, dispositif de traitement de maladies de la peau et dispositif de soins de beauté - Google Patents

Dispositif d'irradiation de lumière biocompatible, procédé d'utilisation d'un dispositif d'irradiation de lumière biocompatible, corps d'étanchéité pour dispositif d'irradiation de lumière biocompatible, procédé de production de corps d'étanchéité pour dispositif d'irradiation de lumière biocompatible, procédé d'utilisation d'un corps d'étanchéité pour dispositif d'irradiation de lumière biocompatible, ensemble, dispositif de traitement de maladies de la peau et dispositif de soins de beauté Download PDF

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Publication number
WO2017038655A1
WO2017038655A1 PCT/JP2016/074898 JP2016074898W WO2017038655A1 WO 2017038655 A1 WO2017038655 A1 WO 2017038655A1 JP 2016074898 W JP2016074898 W JP 2016074898W WO 2017038655 A1 WO2017038655 A1 WO 2017038655A1
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irradiation device
light irradiation
light
bio
light emitting
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PCT/JP2016/074898
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English (en)
Japanese (ja)
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坂上　恵
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合同会社プレアデステクノロジーズ
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Priority to JP2017537818A priority Critical patent/JP6799860B2/ja
Publication of WO2017038655A1 publication Critical patent/WO2017038655A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light

Definitions

  • the present invention relates to a bio-applied light irradiation device, a method of using the bio-applied light irradiation device, a sealed body of the bio-applied light irradiation device, a manufacturing method of a sealed body of the bio-applied light irradiation device, and a sealing of the bio-applied light irradiation device.
  • the present invention relates to a method of using a stationary body, a set, a skin disease treatment apparatus, and a beauty treatment apparatus.
  • a living body that can be easily applied to a living body with many curved surfaces, can be used for a disposable device, is inexpensive, and can suppress deterioration of light irradiation characteristics when stored for a long time in a high-temperature and high-humidity environment.
  • Sealing body of applied light irradiation device manufacturing method of sealing body of living body applied light irradiation device, method of using sealing body of living body applied light irradiation device, sealing body and power source of living body applied light irradiation device Relates to a set having Furthermore, in a state where it is applied to a light irradiation target, a biologically applicable light irradiation device capable of visually confirming that the biologically applied light irradiation device emits light from the outside, a method of using the biologically applicable light irradiation device,
  • the present invention relates to a skin disease treatment apparatus and a beauty treatment apparatus provided with a biologically applied light irradiation device.
  • Light can be used to treat a wide variety of diseases. When light is used alone to treat a disease, this treatment is called phototherapy. When light is used with a formulation, this treatment is called photodynamic therapy (PDT). These therapies can be used to treat a variety of skin and internal diseases. Also in the beauty field, a method for removing acne, unnecessary spots, wrinkles, etc. by irradiating with light rays is known. Such phototherapy is generally carried out in hospitals and beauty facilities using large-sized light irradiation devices. Many such devices for light irradiation have not been installed even in hospitals and beauty facilities.
  • Patent Document 1 describes a disposable portable device using an organic semiconductor as a light source.
  • Patent Document 1 describes a portable device using an organic EL element having a light emitting layer formed on a glass substrate.
  • Patent Document 2 describes a light-emitting medical device that can transmit light to the surface of a patient's skin as a disposable skin care device.
  • Patent Document 3 describes a device that uses an organic light-emitting device as a light source to enhance penetration and action of a pharmacological or cosmetic active ingredient into the skin.
  • Patent Document 1 Japanese Patent No. 4651281
  • Patent Document 2 Japanese Patent Publication No. 2013-532503
  • Patent Document 3 Japanese Patent Publication No. 2013-532497
  • Non-Patent Document 1 KONICA MINOLTA TECHNOLOGY REPORT VOL. 11 (2014) pp. 83-87
  • Non-Patent Document 2 British Journal of Dermatology, 2009, 161, p.170
  • a light emitting element using an organic semiconductor can make a light emitting layer flexible, and if a flexible substrate is used as a substrate, the entire light irradiation device can be flexible. Therefore, if applied to a disposable therapeutic device for phototherapy It was expected that it could be easily applied to a living body with many curved surfaces.
  • a flexible substrate such as a plastic substrate has a very high water vapor transmission rate as compared with a glass substrate conventionally used as a substrate of a light emitting element using an organic semiconductor.
  • the present inventors manufactured a disposable bio-applied light irradiation device in which a light emitting element using an organic semiconductor was formed on a flexible substrate, the light irradiation characteristics deteriorated when stored for a long time in a high temperature and high humidity environment. It was found that a new problem arises.
  • disposable light irradiation devices can be used to easily irradiate light at the desired timing or to irradiate light easily at home or on the go without the help of medical or beauty technicians. This is to satisfy the demands of the workers. Therefore, the disposable light irradiation device needs to be stored for a long time in a place where there is no dedicated storage facility such as a user's home, and there arises a problem that does not occur in a large light irradiation device.
  • Patent Document 1 describes that a flexible device is obtained by using a polyester film instead of glass as a substrate of an organic EL element.
  • a polyester film instead of glass
  • substrate which is a polyester film being inferior.
  • ITO indium tin oxide
  • Patent Document 1 does not describe a method for storing a specific organic EL element in an inert atmosphere.
  • Patent Document 2 a light-emitting medical device using a flexible material such as an elastomer material made of a polymer material as a frame (base material) is applied to a curved surface portion of a patient, and light is uniformly applied to the patient's skin. Is provided. However, Patent Document 2 does not describe a method for storing a disposable skin care device, and does not particularly describe the storage property when a flexible material is used as a base material.
  • Patent Document 3 describes UV exposure using a UV curable resin or a PEN cap as encapsulation of a light emitting device.
  • Patent Document 3 since the UV curable resin is hardened, Patent Document 3 was not intended to provide a flexible organic light emitting device. Further, in the device shown in FIG. 3 of Patent Document 3, it is described that a packing layer and a protective foil are provided. However, these are configurations of a normal organic light emitting device. Therefore, Patent Document 3 does not describe any long-term preservation of a flexible organic light-emitting device.
  • illumination and a display are known as a light irradiation device using an organic light-emitting device that may be used for a long period of time by a user other than the disposable biological light irradiation device (see Non-Patent Documents 1 and 2). ).
  • an inorganic thin film with low moisture and oxygen permeability to ensure moisture resistance, and organic matter that does not impair flexibility A method for producing a substrate with a barrier layer by stacking these thin films is known.
  • Non-Patent Document 1 describes a barrier film for OLED (organic light-emitting diode) illumination that has both barrier properties and flexibility by laminating an inorganic layer / organic layer on a PEN film.
  • OLED organic light-emitting diode
  • the organic semiconductor or quantum dot used for the light-emitting element is vulnerable to water vapor or oxygen, another problem of deterioration due to water vapor or oxygen passing through the hole occurs.
  • the electrode transparent, part of the sealing film is made of a transparent material having a high barrier ability, or the whole sealing film is made of a semi-transparent material, but the light emitting performance is sufficiently enhanced. This is not practical because it is difficult and is extremely expensive due to the complexity of materials and processes.
  • the problem to be solved by the present invention can be easily applied to a living body with many curved surfaces, can be used for a disposable device, is inexpensive, and is irradiated with light when stored for a long time in a high-temperature and high-humidity environment. It is providing the sealing body of the biological application light irradiation device which can suppress deterioration of a characteristic.
  • another problem to be solved by the present invention is that it can be visually confirmed from the outside that the bio-applied light irradiation device emits light in a state where it is applied to a light irradiation target. It is possible to provide a bio-applied light irradiation device that is inexpensive and highly practical.
  • the present inventors have not provided a barrier layer on a substrate of a light-emitting element using an organic semiconductor by storing a bio-applied light irradiation device inside a protective bag having a metal layer. It has been found that when a flexible substrate is used, it can withstand long-term storage in a high-temperature and high-humidity environment without an inert atmosphere. That is, it has been found that even when a bio-applied light irradiation device having an organic semiconductor is manufactured using a flexible substrate having a high water vapor permeability, it can be stored for a long time in a high-temperature and high-humidity environment.
  • the inventors of the present invention as a result of the light emitted from the light emitting element, the light irradiation target is not irradiated and the end face side (in-plane direction). It has also been found that it is possible to confirm whether or not the light emitting element emits light using this light as an index by adopting a configuration in which the leaked light propagated to the outside can be viewed from the outside.
  • a sealed body of a bio-applied light irradiation device having a bio-applied light irradiation device inside a protective bag The biological application light irradiation device has a substrate and a light emitting element, The board is a flexible board, The light emitting element comprises an organic semiconductor or quantum dots; A sealed body of a light application device for living organisms, wherein the protective bag has a metal layer.
  • the light emitting element is preferably an organic electroluminescence element.
  • the sealed body of the light application device for living body according to [1] or [2] has a water vapor transmission rate of 1 ⁇ 10 ⁇ 2 g / m 2 / day or less of the substrate.
  • the substrate preferably contains a thermoplastic resin as a main component.
  • the sealing body for a bio-applied light irradiation device according to any one of [1] to [4] preferably has a substrate thickness of 20 to 200 ⁇ m.
  • the substrate is preferably a polyester film.
  • the sealed body for a bio-applied light irradiation device according to any one of [1] to [6] has a light emitting element only on one surface side of the substrate.
  • the sealed body for a bio-applied light irradiation device according to any one of [1] to [7] has an adhesive on at least a part of the surface of the substrate on which the light emitting element is not formed. It is preferable.
  • the sealing body for a bio-applied light irradiation device according to [8] further has a protective film on the surface of the adhesive material.
  • the sealing body of the light application device for living body described in [8] or [9] can be fixed to the skin of the living body via an adhesive material.
  • the water vapor permeability of the protective bag is 1 ⁇ 10 ⁇ 6 g / m 2 / day or less. It is preferable.
  • the metal layer of the protective bag is preferably an aluminum layer.
  • the protective bag preferably further has an insulating layer.
  • the protective bag is preferably an aluminum moisture-proof bag.
  • the bio-applied light irradiation device is preferably portable.
  • the sealed body of the light application device for living body according to any one of [1] to [15] preferably further has a desiccant inside the protective bag.
  • the irradiation intensity of the light emitting element is preferably 3 to 80 mW / cm 2 .
  • the temperature during light emission of the bio-applied light irradiation device is preferably less than 45 ° C.
  • the sealed body for a bio-applied light irradiation device has a light emitting element only on one surface side of the substrate, It is preferable that the surface of the light emitting element opposite to the substrate and the side surface of the light emitting element are sealed with a metal film.
  • the side surface of the substrate is preferably not sealed with a metal film.
  • the sealed body for a bio-applied light irradiation device has a light emitting layer in which a light emitting element is sandwiched between electrodes, It is preferable that a metal layer be further provided between the electrode positioned between the substrate and the light emitting layer and the substrate.
  • light emitted from the bio-applied light irradiation device is preferably applied to the skin of the living body. .
  • the bio-applied light irradiation device is preferably for medical use or cosmetic use.
  • a sealing step of sealing the biologically applied light irradiation device in the protective bag The biological application light irradiation device has a substrate and a light emitting element, The board is a flexible board, The light emitting element comprises an organic semiconductor or quantum dots; The manufacturing method of the sealing body of the biological application light irradiation device whose protective bag has a metal layer.
  • the sealing step is preferably performed in an atmosphere with a relative humidity of 30% or less.
  • the method for producing a sealed body for a bio-applied light irradiation device according to [24] or [25] is preferably performed while the sealing step is vacuum degassed.
  • the sealing step is performed after further adding a desiccant into the inside of the protective bag. Is preferred.
  • a method for using a sealing body of a bio-applied light irradiation device having a bio-applied light irradiation device having a bio-applied light irradiation device inside a protective bag Attach the living body application light irradiation device taken out of the protective bag to the living body and make the light emitting part emit light,
  • the biological application light irradiation device has a substrate and a light emitting element,
  • the board is a flexible board,
  • the light emitting element comprises an organic semiconductor or quantum dots;
  • the method of using the sealing body for a bio-applied light irradiation device according to [28] has an adhesive material on at least a part of the surface of the substrate on which the light emitting element is not formed, It is preferable to fix the bioapplied light irradiation device to the skin of the living body with an adhesive.
  • the light emitting element is connected to a power source, It is preferable to supply electricity from a power source to cause the light emitting element to emit light.
  • a set having a power source and a sealed body of a bio-applied light irradiation device having a bio-applied light irradiation device inside a protective bag The biological application light irradiation device has a substrate and a light emitting element, The board is a flexible board, The light emitting element comprises an organic semiconductor or quantum dots; A set in which the protective bag has a metal layer.
  • a bio-applied light irradiation device of The plastic sheet is an adherend application surface that is applied to the adherend on the surface opposite to the light emitter formation surface on which the light emitter layer is provided,
  • the phosphor layer contains an organic semiconductor or quantum dots,
  • the biologically applied light irradiation device according to [32] can visually recognize that the uncovered region or the vicinity thereof is shining.
  • the uncovered region is formed so as to indicate a region where the light emitting layer is formed.
  • the shape of the non-covered region is preferably a frame shape along the periphery of the light emitter forming surface.
  • the non-covered region has a portion formed in a belt shape along the periphery.
  • the uncovered region has a portion formed in an arc shape along the periphery.
  • the end surface of the plastic sheet has a region not covered with the metal sealing film.
  • the refractive index at the emission wavelength of the light emitting layer of the plastic sheet is 1.5 to 1.8. preferable.
  • the light body layer emits light by electroluminescence.
  • the bio-applied light irradiation device according to any one of [32] to [40] wherein the light emitting layer emits light by an electrochemiluminescence cell characterized by mixing a light emitting organic material and an electrolyte.
  • the thermal conductivity of the metal sealing film is preferably 100 W / mK or more.
  • the metal sealing film preferably contains a desiccant.
  • the adherend is preferably skin of a living body.
  • a method of using the biologically applied light irradiation device according to any one of [32] to [46] When the entire adherend application surface of the biologically applied light irradiation device is brought into close contact with or close to the adherend, the light emitting layer emits light to irradiate the adherend with the plastic sheet of the biologically applicable light irradiation device.
  • a method of using a bio-applied light irradiation device, wherein whether or not an adherend is irradiated with light is confirmed by visually identifying whether or not at least a part is shining.
  • a skin disease treatment apparatus comprising the biologically applied light irradiation device according to any one of [32] to [46].
  • a cosmetic treatment apparatus comprising the biological application light irradiation device according to any one of [32] to [46].
  • a bio-applied light irradiation device comprising a light emitting element including an organic semiconductor or quantum dots and a flexible substrate, and having a burn prevention mechanism.
  • the living body applied light irradiation device according to [51] includes the constant current circuit that drives the light emitting element, and the burn prevention mechanism has a voltage of the constant current circuit below a specific value. It is preferable that the mechanism reduce the output when it becomes.
  • the biomedical light irradiation device according to [51] includes the constant voltage circuit that drives the light emitting element, and the burn prevention mechanism has a current flowing through the light emitting element exceeding a specific value. It is preferable that the mechanism reduce the output when it becomes.
  • the biologically applied light irradiation device according to [51] has an adhesive region for adhering the biologically applied light irradiation device to a living body, and the burn prevention mechanism has an adhesive region adhesive at a specific temperature or higher.
  • the mechanism is preferably a mechanism that drops the device from the living body due to a decrease in force.
  • the present invention it can be easily applied to a living body with many curved surfaces, can be used for a disposable device, is inexpensive, and has a light irradiation characteristic deterioration when stored for a long time in a high temperature and high humidity environment.
  • the sealing body of the biological application light irradiation device which can be suppressed can be provided.
  • a numerical range represented by using “to” means a range including numerical values described before and after “to” as a lower limit value and an upper limit value.
  • the “main material” means a material having the largest content rate among materials constituting the material unless otherwise specified.
  • the bio-applied light irradiation device of the present invention includes a plastic sheet, a light emitting layer provided on a part of the surface of the plastic sheet, and a metal sealing film that seals the entire light emitting layer between the plastic sheet.
  • the plastic sheet is an adherend application surface in which the surface opposite to the light emitter formation surface on which the light emitter layer is provided is applied toward the adherend.
  • the light emitter layer includes an organic semiconductor or quantum dots, and the metal sealing film covers the light emitter layer, and an uncovered region that is not covered with the metal sealing film is formed on the light emitter forming surface of the plastic sheet. It is provided partially.
  • this living body applied light irradiation device at least a part of the plastic sheet is illuminated when light is emitted from the light emitter layer in a state where the entire adherend application surface of the plastic sheet is in close contact with the adherend. Can be visually recognized.
  • light is emitted from the light emitter layer by bringing the adherend application surface of the plastic sheet into contact with or close to the adherend.
  • the adherend may be any tissue that constitutes the surface of a living body, and most preferably is the skin of the living body. Therefore, the “adherent application surface” can be rephrased as “biological application surface”.
  • the adherend is treated or treated with beauty. There is an effect.
  • the other part of the light from the phosphor layer is the difference in the refractive index between the layers constituting the light application device for living organisms, the difference in the refractive index between the plastic sheet and air, the total reflection at the interface of the metal sealing film Therefore, it propagates to the end face side while being reflected at the interface between these parts.
  • the bio-applied light irradiation device of the present invention there is an uncovered region that is not covered with the metal sealing film on the light-emitting body forming surface of the plastic sheet. It is considered that scattered light of light propagating in the plastic sheet is emitted through the uncovered region, and it is possible to visually recognize how the uncovered region and its vicinity are shining.
  • the light emitter layer is visible when the plastic sheet appears to shine visually.
  • the plastic sheet emits light and the plastic sheet cannot be seen, it can be identified that the phosphor layer is not emitting light. Therefore, it is possible to avoid the problem that the user feels uneasy about not being able to confirm that the light is emitted, or continues to use the bio-applied light irradiation device that does not emit light.
  • the position can be accurately specified by emitting light before being attached to the skin.
  • the entire phosphor layer is sealed with a plastic sheet and a metal sealing film, so that external water vapor and oxygen are effectively prevented from coming into contact with the phosphor layer. Can do. For this reason, it is possible to suppress deterioration of characteristics of the light emitter layer over time.
  • the metal sealing film is much cheaper than a sealing film using a transparent resin material or a semitransparent material having a high barrier ability. For this reason, using this as the sealing film is advantageous in reducing the manufacturing cost of the bio-applied light irradiation device.
  • the metal sealing film has high thermal conductivity, heat generated in the living body applied light irradiation device can be easily dissipated through the metal sealing film.
  • the living body applied light irradiation device is always kept at a low temperature while the light emitting layer emits light, and it is possible to avoid the adherend from being burned by application of the living body applied light irradiation device.
  • this bio-applied light irradiation device uses a plastic sheet as a transparent substrate and uses an organic semiconductor or quantum dots as a light-emitting layer, it is larger in size and shape than those using a glass substrate or a bulk inorganic semiconductor. The degree of freedom is high, and it can be easily adhered to the skin formed of a curved surface. In addition, it is possible to reduce the weight and size.
  • FIG. 1 An example of the biologically applied light irradiation device of the present invention is shown in FIG.
  • the configuration of the bio-applied light irradiation device of the present invention should not be construed as being limited by the specific example shown in FIG.
  • 1 is a plastic sheet
  • 2 is a light emitter layer
  • 3 is a metal sealing film
  • 4 is an adherend.
  • the biological application light irradiation device shown in FIG. 1 has a light extraction improving film 5 and an adhesive tape 6 as an additional configuration.
  • the light extraction improving film 5 is disposed between the center region of the adherend application surface and the adherend
  • the adhesive tape 6 is disposed around the light extraction improvement film 5 and attached to the adherend application surface. .
  • the light applied to the adherend from the living body application light irradiation device when light is emitted from the light emitter layer is referred to as “irradiation light” and can be visually recognized in at least a part of the plastic sheet.
  • the light is sometimes referred to as “light for viewing”.
  • the plastic sheet has a function as a support for supporting the light emitter layer and the metal sealing film constituting the light irradiation body, and the surface opposite to the light emitter formation surface faces the adherend.
  • the adherend application surface to be applied is configured.
  • the adherend application surface of the plastic sheet may be brought into contact with the adherend, or may be brought close to the adherend with a small distance therebetween.
  • the plastic sheet preferably has a refractive index of 1.5 to 1.8, more preferably 1.6 to 1.8, at the emission wavelength of the light emitting layer.
  • the plastic sheet having the refractive index in the above range has a good balance between transmittance and reflectance, and can efficiently transmit the light emitted by the light emitter layer and enter the adherend, and at the same time, the light emitter layer A part of the emitted light can be reflected at the interface and propagated through the inside to the end face side (in-plane direction). As a result, a high therapeutic or cosmetic effect can be obtained on the adherend, and it is possible to clearly see how a part of the plastic sheet is shining. Can be identified.
  • the refractive index of the plastic sheet in the present invention refers to the refractive index at the D line (589.3 nm) of sodium measured by an Abbe refractometer method (JIS D542-1950).
  • the material of the plastic sheet is not particularly limited, but it is preferable that the refractive index is in the above range and is excellent in heat resistance and dimensional stability.
  • Preferred examples of the plastic sheet material include polyester resins such as polyethylene naphthalate (PEN) and polyethylene terephthalate (PET), and polyether resins such as polyethersulfone (PES).
  • Polyethylene naphthalate (PEN) can be suitably used because of its excellent transparency and dimensional stability.
  • “transparent conductive film” supervised by SMC Publishing Co., Ltd., Saburo Tabata plastic materials described in “New Development of Transparent Conductive Film IV” supervised by SMC Publishing Co., Ltd., Yutaka Sawada, and described in Japanese Translation of PCT International Publication No. 2014-515360
  • a plastic material can also be preferably used as a material for the plastic sheet.
  • the thickness of the plastic sheet is not particularly limited, but is preferably 10 to 500 ⁇ m, more preferably 20 to 200 ⁇ m, and further preferably 25 to 125 ⁇ m. Thereby, it is possible to obtain a plastic sheet that is comparatively thin and lightweight and excellent in strength. Further, the plastic sheet of the present invention may be laminated with a glass sheet bent into a curved surface having a thickness of several hundreds of ⁇ m or less. In this specification, the thickness of the plastic sheet and each layer described later is a thickness measured by a method defined in JIS 7130 (many products are sold in contact and non-contact types). .
  • the shape of the plastic sheet in plan view can be selected as appropriate according to the application of the biologically applied light irradiation device, and can be a perfect circle, an ellipse, an ellipse, a polygon such as a triangle, a quadrangle, a pentagon, Either a star shape or an indefinite shape may be used. Moreover, when a plastic sheet has a corner
  • the size of the plastic sheet in a plan view can also be appropriately selected according to the use of the biological application light irradiation device.
  • the length in the long axis direction is preferably 5 to 100 mm, more preferably 10 to 50 mm, and further preferably 10 to 30 mm. preferable.
  • These bio-applied light irradiation devices are preferably placed in a moisture-proof bag made of metal (for example, made of a material mainly made of aluminum) having a water vapor transmission rate of 10 ⁇ 10 ⁇ 6 g / m 2 / day or less. Can withstand long-term storage.
  • the bio-applied light irradiation device is easy to carry in a bag or the like, and the area of the adherend application surface is sufficiently large, and the adherend application surface can be brought into stable contact with the adherend. Become a thing.
  • the plastic sheet may have a single layer configuration or a multilayer configuration.
  • the plastic sheet having a multilayer structure may have a structure in which a plurality of layers mainly composed of plastic materials are laminated, or a layer composed mainly of plastic materials (hereinafter referred to as “plastic layer”) and an inorganic material.
  • a composite structure in which layers as main materials (hereinafter referred to as “inorganic material layers”) are alternately laminated may be used.
  • inorganic material layers layers as main materials
  • each inorganic material layer in the composite structure is preferably 1/10000 to 1/100 of the thickness of the thinnest plastic layer, more preferably 1/5000 to 1/200. Preferably, it is 1/1000 to 1/500.
  • Specific examples of the inorganic material layer include a Si-based inorganic material layer made of SiO 2 , Si—N, and SiON. These Si-based inorganic material layers are excellent in moisture resistance, and can impart a high barrier property against moisture to a biologically applied light irradiation device.
  • the light emitting layer is a layer that generates and emits light, and is provided on a part of the surface of the plastic sheet. Part of the light emitted from the light emitter layer passes through the plastic sheet and is applied to the adherend. The other part of the light radiated from the light emitting layer is reflected on the interface of each layer constituting the light application device for living body and propagates to the end face side.
  • the bio-applied light irradiation device of the present invention it is considered that the scattered light of the light propagating to the end face side is emitted from the non-covered area of the metal sealing film, and it is visually recognized that the non-covered area and its vicinity are shining. it can.
  • the light emitted from the light emitting layer may be any one of fluorescence, delayed fluorescence, and phosphorescence, and two or more of them may be mixed.
  • emits can be suitably selected according to the intended purpose of the biological application light irradiation device. For example, when using a bio-applied light irradiation device for skin cancer treatment, in general, 5-aminolevulinic acid (5-ALA) or its analog is applied to the affected area before light irradiation and left for about 2 to 3 hours.
  • 5-ALA 5-aminolevulinic acid
  • the bio-applied light irradiation device emits light at the absorption wavelength of the porphyrin, creating an excited state and decomposing the porphyrin by singlet oxygen (Non-Patent Documents 3 and 4).
  • the porphyrin derivative (PpIX) is a compound having absorption at 420 nm, 510 nm, 540 nm, 580 nm, and 630 nm (Non-patent Document 5). Any light emission wavelength that matches these absorption wavelengths works effectively.
  • the light emitter layer includes an organic semiconductor or quantum dots, which contribute to light emission and light emission in the light emitter layer.
  • Organic semiconductors or quantum dots have a greater degree of freedom in dimensions and shape when deposited compared to bulk inorganic semiconductors. By using these as materials for the light emitter layer, the light-emitting device for living organisms can be made compact and lightweight. It becomes advantageous for the conversion. In the present invention, it is more preferable to employ an organic semiconductor.
  • the light emission mechanism of the light emitting layer is not particularly limited, it is preferable that the light emission layer is based on electroluminescence (EL) or electrochemiluminescence cell (LEC).
  • EL electroluminescence
  • LEC electrochemiluminescence cell
  • the EL-type phosphor layer emits light by injecting carriers (holes and electrons) from both positive and negative electrodes into the light-emitting material, and the excited light-emitting material generated by the recombination energy of the carriers is radiation-inactivated. is there.
  • This EL type light emitting layer has at least an anode, a cathode, and a light emitting layer provided between the anode and the cathode.
  • the anode may be disposed on the plastic sheet side
  • the cathode may be disposed on the plastic sheet side, but the anode is preferably disposed on the plastic sheet side. .
  • the light emitting layer may be provided between the anode and the cathode, or one or more organic layers may be provided in addition to the light emitting layer.
  • organic layers include a hole transport layer, a hole injection layer, an electron blocking layer, a hole blocking layer, an electron injection layer, an electron transport layer, and an exciton blocking layer.
  • the hole transport layer may be a hole injection / transport layer having a hole injection function
  • the electron transport layer may be an electron injection / transport layer having an electron injection function.
  • 11 represents an anode
  • 12 represents a hole injection layer
  • 13 represents a hole transport layer
  • 14 represents a light emitting layer
  • 15 represents an electron transport layer
  • 16 represents a cathode.
  • an electrode material made of a metal, an alloy, an electrically conductive compound or a mixture thereof having a high work function (4 eV or more) is preferably used.
  • electrode materials include metals such as Au, and conductive transparent materials such as CuI, indium tin oxide (ITO), SnO 2 and ZnO.
  • conductive transparent materials such as CuI, indium tin oxide (ITO), SnO 2 and ZnO.
  • an amorphous material such as IDIXO (In 2 O 3 —ZnO) capable of forming a transparent conductive film may be used.
  • a thin film may be formed by vapor deposition or sputtering of these electrode materials, and a pattern of a desired shape may be formed by photolithography, or when pattern accuracy is not so high (about 100 ⁇ m or more) ), A pattern may be formed through a mask having a desired shape at the time of vapor deposition or sputtering of the electrode material.
  • wet film-forming methods such as a printing system and a coating system, can also be used.
  • the transmittance be greater than 10%
  • the sheet resistance as the anode is preferably 100 ⁇ ⁇ or less, more preferably 20 ⁇ ⁇ or less, and particularly preferably 5 ⁇ ⁇ or less.
  • the film thickness depends on the material, it is usually selected in the range of 10 to 1000 nm, preferably 10 to 200 nm.
  • the anode is preferably designed in consideration of the following.
  • the plastic sheet when a transparent conductive film such as an indium tin oxide film is formed on the surface of a plastic sheet by vapor deposition such as vapor deposition or sputtering, the plastic sheet usually has a lower heat resistance than a glass substrate. Film formation is performed at a relatively low temperature. For this reason, the formed transparent conductive film tends to have low crystallinity and high electrical resistance. Therefore, the transparent conductive film provided on the surface of the plastic sheet in the present invention is formed thicker than the case of forming a film on the surface of the glass substrate, or a conductive transparent material and a material having higher conductivity (highly conductive material). ) In combination to form an anode.
  • a metal such as silver or copper (highly conductive material) is formed in a mesh shape on the surface of a plastic sheet, and then indium tin oxide or the like is covered so as to cover it.
  • a method of forming an anode by forming a conductive transparent material, or a method of forming an anode by applying a conductive polymer such as PEDT: PSS to a metal formed in a mesh shape can be appropriately selected according to the appropriate luminance determined by the target luminance and the dimensions of the bio-applied light irradiation device.
  • the line width is about 1 to 20 ⁇ m, about 500 ⁇ m.
  • a method of reducing the resistance of the electrode by forming a conductive material in a mesh shape is effective, since unevenness occurs on the anode surface, it is desirable to further adopt a method of filling the unevenness and flattening.
  • a coating type hole injection layer or a method of reducing the unevenness by providing a thick highly conductive organic material can be used.
  • a transmissive metal thin film for the anode.
  • metal does not transmit light, but light can be transmitted by forming an ultra-thin film of 20 nm or less.
  • the optimum thickness can be found from the relationship between the sheet resistance and the transmittance, but generally the thickness is preferably 10 nm or less.
  • Ag, Al, Cu, and Au can be used for the metal thin film here, but it is preferable to use Ag in terms of stability and ease of process.
  • the adhesive layer examples include, but are not limited to, metal oxides such as SiOx, SiN, SiON, and Al 2 O 3 .
  • metal oxides such as SiOx, SiN, SiON, and Al 2 O 3 .
  • commercially available electrode substrates in which a transparent conductive film is formed on a plastic sheet include Fleclear (manufactured by TDK), PECF series (manufactured by Pexel Technologies), indium tin oxide coated PET (manufactured by Sigma-Aldrich, 639303-1EA, 5EA.
  • Etc. a carbon nanotube coating film, a film coated with nano silver (manufactured by Toray Industries, Inc.), a silver nanorod using graphene as a conductive film, and the like, and these may be used as a laminated structure of a plastic sheet and an anode.
  • cathode a material having a low work function (4 eV or less) metal (referred to as an electron injecting metal), an alloy, an electrically conductive compound, and a mixture thereof as an electrode material is used.
  • electrode materials include sodium, sodium-potassium alloy, magnesium, lithium, magnesium / copper mixture, magnesium / silver mixture, magnesium / aluminum mixture, magnesium / indium mixture, aluminum / aluminum oxide (Al 2 O 3 ) Mixtures, indium, lithium / aluminum mixtures, rare earth metals and the like.
  • a mixture of an electron injecting metal and a second metal which is a stable metal having a larger work function value than this for example, a magnesium / silver mixture, Magnesium / aluminum mixtures, magnesium / indium mixtures, aluminum / aluminum oxide (Al 2 O 3 ) mixtures, lithium / aluminum mixtures, aluminum and the like are preferred.
  • the cathode can be produced by forming a thin film of these electrode materials by a method such as vapor deposition or sputtering.
  • the sheet resistance as the cathode is preferably several hundred ⁇ / ⁇ or less, and the film thickness is usually selected in the range of 10 nm to 5 ⁇ m, preferably 50 to 200 nm.
  • the film thickness is usually selected in the range of 10 nm to 5 ⁇ m, preferably 50 to 200 nm.
  • the anode or the cathode of the light emitter layer is transparent or translucent, the light emission luminance is improved, which is convenient.
  • a transparent or semi-transparent cathode can be produced by using the conductive transparent material mentioned in the description of the anode as a cathode, and by applying this, a light emitting body in which both the anode and the cathode are transparent Layers can be made.
  • the light emitting layer is a layer that emits light after excitons are generated by recombination of holes and electrons injected from each of the anode and the cathode, and the light emitting material may be used alone for the light emitting layer. , Preferably including a luminescent material and a host material. In the present invention, an organic semiconductor or a quantum dot is used as the light emitting material. These preferable ranges and specific examples will be described later. In order for the bio-applied light irradiation device of the present invention to exhibit high luminous efficiency, it is important to confine singlet excitons and triplet excitons generated in the luminescent material in the luminescent material.
  • a host material in addition to the light emitting material in the light emitting layer.
  • the host material an organic compound in which at least one of excited singlet energy and excited triplet energy has a value higher than that of the light-emitting material can be used.
  • singlet excitons and triplet excitons generated in the light emitting material can be confined in the molecule of the light emitting material, and the light emission efficiency can be sufficiently extracted.
  • high luminous efficiency can be obtained, so that host materials that can achieve high luminous efficiency are particularly limited. And can be used in the present invention.
  • the EL type light emitting layer of the present invention light emission is generated from a light emitting material contained in the light emitting layer.
  • This light emission may be any of fluorescent light emission, delayed fluorescent light emission and phosphorescent light emission, and two or more kinds of light emission may be generated.
  • light emission from the host material may be partly or partly emitted.
  • the amount of the compound of the present invention, which is a light emitting material is preferably 0.1% by weight or more, more preferably 1% by weight or more, and 50% or more. It is preferably no greater than wt%, more preferably no greater than 20 wt%, and even more preferably no greater than 10 wt%.
  • the host material in the light-emitting layer is preferably an organic compound that has a hole transporting ability and an electron transporting ability, prevents the emission of longer wavelengths, and has a high glass transition temperature.
  • organic semiconductors that can be used as the light emitting material will be exemplified.
  • the organic semiconductor used as the light emitting material in the present invention should not be construed as being limited by these specific examples.
  • the light-emitting material described in Non-Patent Document 6 can also be used. (Non-Patent Document 6) Organic Light-emitting Materials ans Devices, Edited by Heng Meng, Tayer & Francis, New York.
  • polymer light emitting material examples include those having polyphenylvinylene (PPV) or polyfluorene (PF) as a basic skeleton.
  • PPV polyphenylvinylene
  • PF polyfluorene
  • Various emission colors such as blue, green, and red can be realized by changing the structure of the copolymer of the polymer light emitting material.
  • a phosphorescent light emitting dopant whose ligand is improved to a dendrimer type is mixed with these basic skeleton polymers, energy transfer occurs and a phosphorescent light emitting polymer light emitting material can be obtained.
  • Typical basic skeleton materials are shown below, and known polymer type organic EL materials including copolymers with triphenylamine derivatives can be used.
  • quantum dots that can be used as a light emitting material will be described.
  • the quantum dots are not particularly limited as long as they are semiconductor nanometer-sized fine particles (semiconductor nanocrystals) and are light-emitting materials that produce a quantum confinement effect (quantum size effect).
  • II such as MgS, MgSe, MgTe, CaS, CaSe, CaTe, SrS, SrSe, SrTe, BaS, BaSe, BaTe, ZnS, ZnSe, ZnTe, CdS, CdSe, CdTe, HgS, HgSe and HgTe.
  • a semiconductor crystal containing a group IV semiconductor or the like a semiconductor compound containing three or more elements such as InGaP can be given.
  • a semiconductor crystal obtained by doping the semiconductor compound with a rare earth metal cation or a transition metal cation such as Eu 3+ , Tb 3+ , Ag + , or Cu + can be used.
  • semiconductor crystals such as CdS, CdSe, CdTe, and InGaP are preferable from the viewpoints of ease of production, controllability of particle diameters for obtaining light emission in the visible range, and fluorescence quantum yield.
  • the quantum dot may be composed of one kind of semiconductor compound or may be composed of two or more kinds of semiconductor compounds, for example, a core made of a semiconductor compound and a shell made of a semiconductor compound different from the core. It may have a core-shell type structure.
  • the core-shell type quantum dot uses a material with a higher band gap than the semiconductor compound that forms the core as the semiconductor compound that forms the core so that excitons are confined in the core. Can be increased.
  • Examples of the core-shell structure (core / shell) having such a bandgap size relationship include CdSe / ZnS, CdSe / ZnSe, CdSe / CdS, CdTe / CdS, InP / ZnS, GaP / ZnS, Si / ZnS, Examples include InN / GaN, InP / CdSSe, InP / ZnSeTe, GaInP / ZnSe, GaInP / ZnS, Si / AlP, InP / ZnSTe, GaInP / ZnSTe, and GaInP / ZnSSe.
  • the size of the quantum dots may be appropriately controlled depending on the material constituting the quantum dots so that light having a desired wavelength can be obtained.
  • the particle size of the quantum dot decreases, the energy band gap increases. That is, as the crystal size decreases, the light emission of the quantum dots shifts to the blue side, that is, to the high energy side. Therefore, by changing the size of the quantum dots, the emission wavelength can be adjusted over the wavelength range of the spectrum in the ultraviolet region, the visible region, and the infrared region.
  • the particle diameter (diameter) of the quantum dots is preferably in the range of 0.5 to 20 nm, and particularly preferably in the range of 1 to 10 nm. The narrower the quantum dot size distribution, the clearer the emission color.
  • the shape of the quantum dots is not particularly limited, and may be spherical, rod-shaped, disk-shaped, or other shapes.
  • the particle diameter of the quantum dot can be a value when it is assumed to be a true sphere having the same volume.
  • Information such as the particle size, shape, and dispersion state of the quantum dots can be obtained by a transmission electron microscope (TEM). Further, the crystal structure and particle size of the quantum dots can be known by X-ray crystal diffraction (XRD). Furthermore, information on the particle diameter and surface of the quantum dots can be obtained from the UV-Vis absorption spectrum.
  • the injection layer is a layer provided between the electrode and the organic layer for lowering the driving voltage and improving the luminance of light emission.
  • the injection layer can be provided as necessary.
  • the blocking layer is a layer that can prevent diffusion of charges (electrons or holes) and / or excitons existing in the light emitting layer to the outside of the light emitting layer.
  • the electron blocking layer can be disposed between the light emitting layer and the hole transport layer and blocks electrons from passing through the light emitting layer toward the hole transport layer.
  • a hole blocking layer can be disposed between the light emitting layer and the electron transporting layer to prevent holes from passing through the light emitting layer toward the electron transporting layer.
  • the blocking layer can also be used to block excitons from diffusing outside the light emitting layer. That is, each of the electron blocking layer and the hole blocking layer can also function as an exciton blocking layer.
  • the term “electron blocking layer” or “exciton blocking layer” as used herein is used in the sense of including a layer having the functions of an electron blocking layer and an exciton blocking layer in one layer.
  • the hole blocking layer has a function of an electron transport layer in a broad sense.
  • the hole blocking layer has a role of blocking holes from reaching the electron transport layer while transporting electrons, thereby improving the recombination probability of electrons and holes in the light emitting layer.
  • the material for the hole blocking layer the material for the electron transport layer described later can be used as necessary.
  • the electron blocking layer has a function of transporting holes in a broad sense.
  • the electron blocking layer has a role to block electrons from reaching the hole transport layer while transporting holes, thereby improving the probability of recombination of electrons and holes in the light emitting layer. .
  • the exciton blocking layer is a layer for preventing excitons generated by recombination of holes and electrons in the light emitting layer from diffusing into the charge transport layer. It becomes possible to efficiently confine in the light emitting layer, and the light emission efficiency of the device can be improved.
  • the exciton blocking layer can be inserted on either the anode side or the cathode side adjacent to the light emitting layer, or both can be inserted simultaneously.
  • the layer when the exciton blocking layer is provided on the anode side, the layer can be inserted adjacent to the light emitting layer between the hole transport layer and the light emitting layer, and when inserted on the cathode side, the light emitting layer and the cathode Between the luminescent layer and the light-emitting layer.
  • a hole injection layer, an electron blocking layer, or the like can be provided between the anode and the exciton blocking layer adjacent to the anode side of the light emitting layer, and the excitation adjacent to the cathode and the cathode side of the light emitting layer can be provided.
  • an electron injection layer, an electron transport layer, a hole blocking layer, and the like can be provided.
  • the blocking layer is disposed, at least one of the excited singlet energy and the excited triplet energy of the material used as the blocking layer is preferably higher than the excited singlet energy and the excited triplet energy of the light emitting material.
  • the hole transport layer is made of a hole transport material having a function of transporting holes, and the hole transport layer can be provided as a single layer or a plurality of layers.
  • the hole transport material has any one of hole injection or transport and electron barrier properties, and may be either organic or inorganic.
  • hole transport materials that can be used include, for example, triazole derivatives, oxadiazole derivatives, imidazole derivatives, carbazole derivatives, indolocarbazole derivatives, polyarylalkane derivatives, pyrazoline derivatives and pyrazolone derivatives, phenylenediamine derivatives, arylamine derivatives, Examples include amino-substituted chalcone derivatives, oxazole derivatives, styrylanthracene derivatives, fluorenone derivatives, hydrazone derivatives, stilbene derivatives, silazane derivatives, aniline copolymers, and conductive polymer oligomers, particularly thiophene oligomers.
  • An aromatic tertiary amine compound and an styrylamine compound are preferably used, and an aromatic tertiary amine compound is more preferably used.
  • the electron transport layer is made of a material having a function of transporting electrons, and the electron transport layer can be provided as a single layer or a plurality of layers.
  • the electron transport material (which may also serve as a hole blocking material) may have a function of transmitting electrons injected from the cathode to the light emitting layer.
  • Examples of the electron transport layer that can be used include nitro-substituted fluorene derivatives, diphenylquinone derivatives, thiopyran dioxide oxide derivatives, carbodiimides, fluorenylidenemethane derivatives, anthraquinodimethane and anthrone derivatives, oxadiazole derivatives, and the like.
  • a thiadiazole derivative in which the oxygen atom of the oxadiazole ring is substituted with a sulfur atom, and a quinoxaline derivative having a quinoxaline ring known as an electron withdrawing group can also be used as an electron transport material.
  • a polymer material in which these materials are introduced into a polymer chain or these materials are used as a polymer main chain can also be used.
  • the compound represented by the general formula (1) may be used not only for the light emitting layer but also for layers other than the light emitting layer.
  • the compound represented by General formula (1) used for a light emitting layer and the compound represented by General formula (1) used for layers other than a light emitting layer may be same or different.
  • the compound represented by the general formula (1) may be used for the injection layer, blocking layer, hole blocking layer, electron blocking layer, exciton blocking layer, hole transporting layer, electron transporting layer, and the like. .
  • the method for forming these layers is not particularly limited, and the layer may be formed by either a dry process or a wet process.
  • preferable materials that can be used for the EL light-emitting layer are given below.
  • the material that can be used in the present invention is not limited to the following exemplary compounds. Moreover, even if it is a compound illustrated as a material which has a specific function, it can also be diverted as a material which has another function.
  • R and R 1 to R 10 in the structural formulas of the following exemplary compounds each independently represent a hydrogen atom or a substituent. n represents an integer of 3 to 5.
  • Preferable compounds that can be used as the host material for the light emitting layer include, for example, compounds described in paragraphs [0055] to [0059] of JP-A-2015-129240.
  • Preferable compounds that can be used as the hole injection material include, for example, compounds described in paragraph [0061] of JP-A-2015-129240.
  • Preferable compounds that can be used as the hole transporting material include, for example, compounds described in paragraphs [0063] to [0068] of JP-A-2015-129240.
  • Preferable compounds that can be used as the electron blocking material include, for example, compounds described in paragraph [0070] of JP-A-2015-129240.
  • Preferable compounds that can be used as the hole blocking material include, for example, compounds described in paragraph [0072] of JP-A-2015-129240.
  • Preferable compounds that can be used as the electron transport material include, for example, compounds described in paragraphs [0074] to [0076] of JP-A-2015-129240.
  • Preferable compounds that can be used as the electron injecting material include, for example, compounds described in paragraph [0078] of JP-A-2015-129240.
  • a stabilizing material can be mentioned as a material which can be added.
  • Preferable compounds that can be used as the stabilizing material include, for example, compounds described in paragraph [0080] of JP-A-2015-129240. The description of each paragraph of JP-A-2015-129240 cited in this paragraph is cited here as a part of this specification.
  • each layer constituting the above EL type phosphor layer is not particularly limited, and it may be produced by either a dry process or a wet process.
  • the LEC-type phosphor layer is a device having a simple structure in which a light-emitting layer sandwiches a mixture of a light-emitting organic semiconductor material and an electrolyte with electrodes.
  • ions move at the interface between the electrode and the organic material layer, a pin junction is automatically formed at the cathode and anode interface, the carrier balance is automatically optimized, and the device operates at a low voltage.
  • Has characteristics A specific structural example of the LEC-type light emitter layer is shown in FIG. In FIG. 3, 21 represents an anode, 22 represents a light emitting layer, and 23 represents a cathode.
  • the light emitting layer of the LEC type light emitter layer includes a polymer semiconductor material and an electrolyte (Non-patent Document 7).
  • the polymer semiconductor material can be phosphorescent using a so-called doping material, and includes an organic semiconductor or a quantum dot.
  • the quantum dots reference can be made to the explanation and preferred range of the quantum dots used in the EL type light emitting layer.
  • organic semiconductors that can be used as light emitting materials are limited to polymer fluorescent materials, but in principle, it is possible to dope phosphorescent light emitting materials and use low molecular fluorescent materials or phosphorescent materials. is there.
  • phosphorescent light emitting materials are limited to polymer fluorescent materials, but in principle, it is possible to dope phosphorescent light emitting materials and use low molecular fluorescent materials or phosphorescent materials. is there.
  • ionic liquid a well-known thing is widely used by a patent document and a nonpatent literature.
  • the thickness of the luminescent layer varies depending on whether it is an EL type or an LEC type, but is preferably 2 ⁇ m or less, more preferably 1000 nm or less in order to reduce the driving voltage of the bio-applied light irradiation device. Preferably, it is 500 nm or less. In view of obtaining sufficient light for irradiation and light for visual recognition, the thickness of the EL light-emitting layer is preferably 10 to 500 nm, more preferably 10 to 200 nm, and 20 More preferably, it is ⁇ 150 nm. Further, the thickness of the LEC type light emitting layer is preferably 200 nm to 2 ⁇ m.
  • the light emitting layer is provided on a part of the surface of the plastic sheet.
  • the surface of the plastic sheet surface on the side where the light emitter layer is provided is referred to as a “light emitter formation surface”, and the region of the light emitter formation surface where the light emitter layer is provided is referred to as “light emitter”.
  • a region where no light emitter layer is provided is referred to as a “layer formation region”, and a “light emitter layer non-formation region”.
  • this living body applied light irradiation device when light is emitted from the light emitter layer, light is emitted toward the adherend from a region corresponding to the light emitter layer forming region on the adherend application surface.
  • the region corresponding to the light emitter layer forming region of the adherend application surface is a region obtained by orthogonally projecting the light emitter layer onto the substrate, out of the adherend application surface of the plastic sheet. It corresponds to the “light emitting part” of the light irradiation device for encapsulant.
  • the position, shape, and dimensions of the light emitter layer forming region on the light emitter forming surface are not particularly limited, but the light emitter layer forming region is preferably a region excluding the vicinity of the periphery of the light emitter forming surface. In this case, the irradiation light is radiated from a region excluding the vicinity of the periphery of the adherend application surface, that is, the central region.
  • the adherend application surface can be applied to the adherend with better adhesion in the central region than in the vicinity of the periphery, so that the irradiation light is radiated from the central region of the adherend application surface.
  • the adherend can be irradiated with irradiation light uniformly and efficiently.
  • the distance from the periphery of the light emitter layer formation region on the light emitter formation surface is preferably 0.5 to 50 mm mm, more preferably 1 to 20 mm at the shortest distance. More preferably, it is 1 to 10 mm.
  • the shape of the light emitter layer forming region is not particularly limited, but since it is easy to ensure a large area, it is similar to the shape of the light emitter forming surface or the same type as the light emitter forming surface. It is preferable.
  • the same type of shape includes a perfect circle, an ellipse, an ellipse, and polygons having the same number of angles. Polygons having the same number of corners are of the same type or similar shape even if any one of the corners is rounded.
  • the light emitter formation region does not have to be a continuous shape, and may be a stripe shape, a lattice shape, a dot shape, or the like.
  • 4 shows a specific pattern example of the light emitting layer forming region.
  • the region surrounded by the outermost frame represents the light emitter forming surface 1a
  • the region surrounded by the innermost frame represents the light emitter layer forming region 2a.
  • the region surrounded by the frame represents the covered region of the metal sealing film 3
  • the region between the outermost frame and the middle frame represents the non-covered region 1 n of the metal sealing film 3.
  • 4 (a), 4 (b), and 4 (d) show the case where the shape of the light emitter layer forming region 2a is similar to the shape of the light emitter forming surface 1a
  • FIG. 4 (c) shows the light emitter layer forming region.
  • the case where the shape of 2a is the same type as the shape of the light emitter forming surface 1a is shown.
  • the metal sealing film seals the entire light emitter layer between the plastic sheet, covers the light emitter layer on the light emitter formation surface of the plastic sheet, and seals the metal on the light emitter formation surface. It is partially provided so as to form an uncovered region that is not covered with a stop film.
  • the bio-applied light irradiation device of the present invention when there is an uncoated region that is not covered with the metal sealing film on the surface where the light emitter is formed as described above, it propagates in the plastic sheet when light is emitted from the light emitter layer. It is possible to visually recognize that the scattered light of the emitted light is emitted to the outside in the uncovered region and the uncovered region and its vicinity are shining.
  • the material constituting the metal sealing film may be a metal material having a high barrier property and high reflectance, and more preferably a metal material having a high thermal conductivity.
  • the thermal conductivity of the metal sealing film is preferably 100 W / mK or more, and more preferably 200 W / mK or more. In this specification, the thermal conductivity of the metal sealing film is a value measured by a laser flash method.
  • Preferred materials for the metal sealing film include stainless steel, aluminum, tungsten, copper and the like.
  • the increase in the surface temperature of the bio-applied light irradiation device is small even when the heat emission generated when the organic EL illuminator is illuminated with high luminance is efficiently emitted with high luminance. It can be used as a device that adheres to the skin. It is preferable that the desirable surface temperature can be kept for a long time at a temperature that does not cause low-temperature burns, and is specifically 43 ° C. or lower. Low temperature burns are said to occur in 4-10 hours at 44 ° C.
  • the heat dissipating treatment with the metal sealing film is important. It is important to form these metal sealing films so as to cover the upper surface of the organic EL light-emitting body, particularly the light emitting area sandwiched between the cathode and the anode. Since the metal encapsulating film exhibits electrical conductivity, if it is formed as it is on the upper part of the electrode, it will be short-circuited.
  • These resin layers which are desirably formed, desirably contain a desiccant in order to prevent moisture and oxygen from entering from the resin bonding end face.
  • the thickness of the adhesive layer provided on the metal sealing film is preferably as thin as possible in order to suppress intrusion of water or oxygen, but is preferably 0.5 to 50 ⁇ m, and more preferably 1 to 30 ⁇ m.
  • the thickness of the metal sealing film is not particularly limited, but is preferably 10 to 500 ⁇ m, more preferably 10 to 200 ⁇ m, and even more preferably 10 to 50 ⁇ m.
  • the metal sealing film partially covers the light emitter formation surface of the plastic sheet so as to cover the light emitter and to form an uncovered region not covered with the metal sealing film on the light emitter formation surface.
  • the position, shape, and dimensions of the non-covered area on the light emitter forming surface are not particularly limited as long as the non-covered area does not overlap the light emitter layer forming area. It is preferable that a region is formed. Thereby, it is easy to ensure the light emitter layer forming region in a region corresponding to the central region of the adherend application surface, and light irradiation to the adherend can be performed uniformly and efficiently.
  • the shape (pattern) of the non-covered region can be appropriately selected in consideration of ease of visual recognition, design, etc., but as an example of a shape that emphasizes ease of visual recognition, the periphery of the light emitter forming surface
  • the frame shape along the whole can be mentioned.
  • the shape of the non-covered region may be a band shape or a key shape along a part of the periphery of the light emitter forming surface.
  • the shape of the non-covered region when the light emitter forming surface is a perfect circle or an ellipse may be an arc shape along a part of the periphery of the light emitter forming surface, and the light emitter forming surface may be The shape of the non-covered region in the case of an oval shape may be an arc shape or a belt shape along a part of the periphery of the light emitter forming surface.
  • the non-covering region may overlap with the periphery of the light-emitting body forming surface or may be separated from the periphery, but preferably overlaps with the periphery.
  • the uncovered region does not have to be a continuous shape, and may be a stripe shape, a dot shape, or the like.
  • FIG. 4 shows a specific pattern example of the uncovered area. 4 (a) to 4 (d), the region between the outermost frame and the intermediate frame represents the uncovered region 1n, and FIGS. 4 (a), 4 (c), and 4 (d) show the uncovered region 1n.
  • FIG. 4C shows the case where the shape of the uncovered region 1n is a belt shape.
  • the light intensity in the non-covered area when light is emitted from the light-emitting layer is 1 cd / m 2 or more, is 10 cd / m 2 or more Is preferred.
  • the luminance of light in the non-covered area is a value measured using a luminance meter (BM-9A, manufactured by Dopcon Techno House).
  • the metal sealing film does not cover the end face of the plastic sheet.
  • the light propagating between the interfaces of the layers constituting the living body application light irradiation device has directivity toward the end face side of the plastic sheet. Therefore, since the end surface of the plastic sheet is exposed, the propagating light can be efficiently taken out from the end surface, and it can be visually recognized that the end surface is shining strongly. Thereby, the user who uses the biological application light irradiation device can more clearly identify whether or not the light emitting layer emits light.
  • a part of the end face of the plastic sheet may be exposed from the metal sealing film, or the whole end face may be exposed from the metal sealing film, but the whole end face is exposed from the metal sealing film. It is preferable.
  • the uncovered region may be formed so as to indicate the light emitting layer forming region.
  • the light emitting layer forming region cannot be accurately recognized from above the metal sealing film. For this reason, it is also considered that it is not easy to closely attach the living body applied light irradiation device to a desired position.
  • the living body applicable light irradiation device can be easily adhered to a desired position.
  • the metal encapsulating film and the non-covered region can be visually distinguished from each other due to the difference in contrast and the color, the bioapplied light irradiation device can be brought into close contact with the desired position even when the light emitting layer does not emit light.
  • the non-covered region appears to shine to show the light-emitting layer forming region if the light-emitting layer is brought into close contact. Therefore, the biological application light irradiation device can be brought into close contact with a desired position.
  • the details of the non-covering region formed so as to indicate the light emitting layer forming region are as long as the region where the light emitting layer is formed can be visually recognized from the metal sealing film side. Is not particularly limited.
  • the region away from the periphery of the light emitter layer forming region by a specific distance or more is set as an uncovered region, the light emitter layer forming region can be visually recognized from the metal sealing film side.
  • the specific distance here can be, for example, 3 mm or more, 5 mm or more, 10 mm or more, 20 mm or more, or 50 mm or less, 30 mm or less.
  • all the regions separated by a specific distance or more from the periphery of the phosphor layer forming region may be uncovered regions, or may have a specific width (for example, 1 mm or more, 3 mm or more, 5 mm or more, 20 mm or less, 10 mm or less).
  • the non-covered region may be formed in such a manner as to frame the light emitter layer forming region.
  • uncovered regions may be formed so as to indicate the four corners of the rectangle.
  • the uncovered region can be shaped as an arrow to show four corners.
  • the shape of the uncovered region is not particularly limited, and may be a perfect circle, an ellipse, an ellipse, a polygon such as a triangle, a quadrangle, or a pentagon, a star, an indefinite shape, a stripe, a lattice, a dot, etc. Either is acceptable.
  • the shape of the non-covered region is a shape having a corner, the corner may be rounded.
  • an adhesive tape may be attached to at least a part of the adherend application surface as necessary.
  • the pressure-sensitive adhesive tape has a pressure-sensitive adhesive layer and a release sheet laminated on one side of the pressure-sensitive adhesive layer, and the other side of the pressure-sensitive adhesive layer is attached to the adherend application surface.
  • the release sheet is peeled off and the exposed surface of the adhesive material layer is attached to the adherend.
  • the adhesive material used for the adhesive material layer for example, a single-sided or double-sided tape manufactured by 3M Corporation can be used.
  • the use of a silicone-type pressure-sensitive adhesive is advantageous when reattaching.
  • the sticking location of the adhesive tape on the adherend application surface is not particularly limited, it is preferably within the range of the region corresponding to the light emitting layer non-forming region. Thereby, the light radiated
  • the size of the pressure-sensitive adhesive tape varies depending on the area of the adherend application surface, but the width is 1 to 20 mm, preferably 2 to 10 mm from the viewpoint of stably fixing the bio-applied light irradiation device to the adherend. However, there may be a wide portion and a narrow portion depending on the shape of the light irradiation device.
  • the biological application light irradiation device of the present invention may have a light extraction improving film as necessary.
  • the light extraction improving film has a function of improving light extraction efficiency from the adherend application surface, and is disposed between the central region of the adherend application surface and the adherend.
  • As the light extraction improving film a plastic film obtained by processing various shapes (for example, hemisphere or polygonal pyramid shape) can be used.
  • photochemotherapeutic agent layer for the description and the preferred range of the photochemotherapeutic agent layer, reference can be made to the “photochemotherapeutic agent layer” column of “biologically applied light irradiation device for encapsulant”.
  • ⁇ Usage method of light irradiation device applied to living body In order to use the biologically applied light irradiation device of the present invention, an adherend is brought into contact with or close to the adherend application surface, and then a voltage is applied to the anode and cathode of the light emitter layer to emit light from the light emitter layer. . Thereby, at the same time, at least a part of the plastic sheet shines while irradiating light is emitted from the adherend application surface. By the light for irradiation from the adherend application surface, it is possible to obtain an effect of treatment or beauty by light on the adherend. At this time, it is confirmed that at least a part of the plastic sheet is shining to confirm that the luminescent layer emits light.
  • the living body-applied light irradiation device of the present invention is used while the adherend application surface is in contact with the adherend. Thereby, light can be irradiated to an adherend stably and uniformly.
  • the living body applied light irradiation device emits light in the conventional living body applied light irradiation device.
  • the living body applicable light irradiation device of the present invention even if it is used in such a usage mode, at least part of the plastic sheet glows when emitted from the light emitter layer. It can be easily confirmed that is emitting light. That is, the biologically applied light irradiation device of the present invention can obtain a particularly remarkable effect when the adherend application surface is used in contact with the adherend.
  • the sealed body of the bio-applied light irradiation device of the present invention is a sealed body of a bio-applied light irradiation device having the bio-applied light irradiation device inside the protective bag,
  • the biological application light irradiation device has a substrate and a light emitting element,
  • the board is a flexible board,
  • the light emitting element comprises an organic semiconductor or quantum dots;
  • the protective bag has a metal layer.
  • the sealing body of the living body applied light irradiation device can be easily applied to a living body with many curved surfaces because the substrate of the living body applied light irradiation device is a flexible substrate. Moreover, by having the living body-applied light irradiation device inside the protective bag, it is possible to suppress the deterioration of the light irradiation characteristics of the living body-applied light irradiation device when stored for a long time in a high temperature and high humidity environment. For this reason, since a substrate having a relatively high water vapor transmission rate can be used as the flexible substrate of the bio-applied light irradiation device, the bio-applied light irradiation device can be configured as an inexpensive article that can be disposable.
  • a flexible substrate having a water vapor transmission rate of 1 ⁇ 10 ⁇ 6 g / m 2 / day or less is generally employed.
  • the sealing body of the present invention when used, the water vapor transmission rate is low.
  • an inorganic substance eg, SiO, SiN, SiON
  • Etc. are adopted. If the inorganic layer is made thick, the water vapor transmission rate can be lowered sufficiently, but there is a problem that cracking tends to occur when bent. For this reason, it has been attempted to prevent cracking by thinning the inorganic layer and laminating it with an organic layer (for example, a polymer). However, there is a drawback in that it is complicated and increases the cost. In the case of the sealing body of the present invention, even a flexible substrate having a relatively thin inorganic layer can be employed, and thus such a problem can be avoided. When making the sealing body of this invention, it is possible to employ
  • the sealing body of the present invention is distinguished from the “biologically-applied light irradiation device” of the above-mentioned “biologically-applied light irradiation device that can visually recognize that at least a part of the plastic sheet is shining”.
  • the living body applied light irradiation device may be referred to as a “sealed light irradiation device”.
  • the “sealing body light irradiation device” the above “biologically applied light irradiation device capable of visually recognizing that at least a part of the plastic sheet is shining” may be used.
  • the biological application light irradiation device which the sealing body of this invention has has a board
  • This biologically applied light irradiation device is accommodated in a protective bag having a metal layer.
  • the bio-applied light irradiation device included in the sealing body may be the above-described “bio-applied light irradiation device that can visually recognize that at least a part of the plastic sheet is shining”, but is not limited thereto.
  • any of light emitting devices including organic semiconductors or quantum dots and a bio-applied light irradiation device having a flexible substrate can be employed.
  • the sealing body for a bio-applied light irradiation device of the present invention may have only one bio-applied light irradiation device or a plurality of bio-applied light irradiation devices.
  • it is preferable that the bio-applied light irradiation devices are put in the protective bag one by one because deterioration after taking out can be suppressed even when the user uses it alone in only one place. .
  • FIG. 5 As an example of the configuration of the bio-applied light irradiation device included in the sealing body of the present invention, an organic EL element used as a light emitting element is shown in FIG.
  • 202 represents a substrate
  • 217 represents a light emitting element.
  • the surface of the substrate 202 on which the light emitting element 217 is provided is referred to as “light emitting element forming surface”
  • the surface of the substrate 202 opposite to the light emitting element forming surface is referred to as “biological application surface”.
  • the bio-applied light irradiation device shown in FIG. 5 includes, as additional components, a metal layer 203, a metal sealing film 212, a fill material 210, a sealing adhesive 211, a light extraction improving film 216, and an adhesive material layer 201. have.
  • the metal layer 203 is interposed between the substrate 202 and the light emitting element 217.
  • the metal sealing film 212 is arranged so as to seal the entire light emitting element 217 between the substrate 202 and the filling material 210 and the sealing adhesive 211.
  • the light extraction improving film 216 is arranged on the living body application surface of the substrate 202 so as to coincide with the light emitting unit 218, and the adhesive layer 201 is arranged around the light emitting unit 218.
  • the biological application light irradiation device used in the present invention has a substrate, and the substrate is a flexible substrate.
  • the water vapor permeability of the substrate is preferably 1 ⁇ 10 ⁇ 2 g / m 2 / day or less.
  • the substrate preferably contains a thermoplastic resin as a main component.
  • the “main component” in the substrate of the bio-applied light irradiation device included in the sealing body refers to a component that occupies 50% by mass or more of the total mass of the substrate.
  • the substrate preferably contains 80% by mass or more of the thermoplastic resin, more preferably 90% by mass or more.
  • the substrate may be a single layer or a laminate of two or more layers.
  • the substrate is preferably a single layer. It is preferable that the substrate does not have a layer that does not have a thermoplastic resin as a main component, such as a layer that has an inorganic film as a main component, in order to be usable for a disposable device and to be inexpensive.
  • thermoplastic resin which is a main component of a board
  • substrate examples include polyester.
  • the substrate is preferably a polyester film, more preferably a polyethylene terephthalate (PET) film or a polyethylene naphthalate (PEN) film, and particularly preferably a PEN film.
  • PET polyethylene terephthalate
  • PEN polyethylene naphthalate
  • Water vapor transmission rate is about 21g / m 2 / day, about at PEN film 6.7g / m 2 / day with a PET film.
  • a flexible substrate having a water vapor transmission rate of 1 ⁇ 10 ⁇ 2 g / m 2 / day or less by forming an inorganic layer (for example, SiO, SiN, SiON) on these films.
  • the thickness of the inorganic layer is preferably 200 nm from the viewpoint of preventing cracks.
  • this invention does not exclude that a board
  • the thickness of the substrate is preferably 20 to 200 ⁇ m, more preferably 20 ⁇ m to 125 ⁇ m, and particularly preferably 20 ⁇ m to 80 ⁇ m.
  • the thickness of the film substrate is reduced, the rigidity of the film can be reduced. As a result, the followability to a living body with many curved surfaces (for example, the skin of the living body) is improved, and it is difficult to peel off during use.
  • the width of the adhesive region to the living body by the adhesive material layer described later to make the light emitting surface wide.
  • region is made small, the subject that the adhesiveness to skin will fall arises. This problem can be solved by reducing the thickness of the substrate.
  • the surface temperature of the skin rises in a range in which low-temperature burns do not occur while the light application device for living body is brought into close contact with a living body (for example, skin) and light is emitted.
  • the present inventor has also found a new problem that the adhesiveness to the skin decreases as the surface temperature of the skin increases. This new problem occurs particularly when a substrate having high rigidity is used. This new problem has been found while studying a bio-applied light irradiation device in which a light emitting surface is brought into close contact with the skin, and has not been known so far, and has not been a problem that can be easily estimated by those skilled in the art. This new problem can be solved by reducing the thickness of the substrate.
  • the light emitting element includes an organic semiconductor or a quantum dot.
  • the form of the light-emitting element is not particularly limited, but the outer shape is preferably a layered shape.
  • a light-emitting element whose outer shape is a layer may be referred to as a “light-emitting layer”.
  • Examples of light-emitting elements including organic semiconductors include organic electroluminescent elements (also referred to as organic light-emitting diodes: OLEDs), polymer light-emitting diodes (PLEDs), organic light-emitting electrochemical cells (OLEC), and quantum dots made of inorganic materials. be able to.
  • the light emitting element is preferably an organic electroluminescence (EL) element, and is a layered organic EL element, that is, an EL type light emitting layer. More preferred.
  • EL organic electroluminescence
  • the layer structure of the EL type phosphor layer refer to the description in the section of [EL type phosphor layer] in the above-mentioned “biologically applied light irradiation device in which at least part of the plastic sheet can be visually recognized”. Can do.
  • the light emitting element 217 of the light application device for living body shown in FIG. 5 is an EL type light emitter layer.
  • 204 is an anode
  • 205 is a hole injection layer
  • 206 is an interlayer (even a hole transport layer).
  • 207) represents a light emitting layer
  • 208 represents an electron injection layer
  • 209 represents a cathode.
  • an electron transport layer or a hole blocking layer may be provided between the light emitting layer 207 and the electron injection layer 208.
  • a light emitting device typically includes electrodes that act as an anode and a cathode.
  • electrodes that act as an anode and a cathode.
  • anode and cathode For the description and preferred range of the anode and cathode, and constituent materials thereof, see the columns of “Anode” and “Cathode” in the above-mentioned “biologically applied light irradiation device in which at least a part of the plastic sheet can be visually recognized”. can do.
  • ITO ITO, silver, aluminum or the like
  • a transparent conductive material as the material of the electrode on the substrate side.
  • ITO is preferable as the material of the anode
  • aluminum is preferable as the material of the cathode.
  • the ITO anode having a work function of about 5.0 eV can inject holes more efficiently into the hole injection layer than the silver anode having a work function of about 4.3 eV.
  • the electrode on the substrate side of the anode and the cathode is formed as a transparent conductive film so that the resistance becomes as small as possible.
  • ITO used for the transparent conductive film is formed by sputtering.
  • the resin substrate when a resin substrate is used as the flexible substrate, the resin substrate generally has low heat resistance, so that the crystallization is enhanced by annealing the ITO sputtered at a high temperature as in the case of forming the ITO electrode on the glass substrate. Is difficult. Therefore, the ITO electrode formed on the flexible substrate has a lower crystallinity than usual and tends to have a high resistance.
  • an ITO anode having a work function of about 5.0 eV is provided on a metal film having a low work function such as a silver thin film, the hole injection efficiency is improved due to the low resistance of the metal.
  • the voltage drop according to the distance from the voltage supply source when the voltage is applied to emit light is less likely to increase, and light emission unevenness is less likely to occur.
  • light emission unevenness is hardly caused.
  • the temperature unevenness of the biologically applied light irradiation device can be remarkably suppressed, and a short circuit of the biologically applied light irradiation device can be avoided.
  • membrane which reduces the resistance of this electrode may serve as the function of the metal layer as a waterproof layer mentioned later.
  • the electrode on the substrate side may be a combination of a stripe-shaped or mesh-shaped metal layer and an ITO transparent conductive film.
  • ITO may be entirely formed on a flexible substrate by sputtering or the like, and a stripe or mesh metal layer may be formed thereon with a metal such as silver to lower the resistance.
  • a stripe or mesh metal layer may be formed of a metal such as silver on a flexible substrate, and ITO may be formed on the entire surface by sputtering or the like to reduce the resistance.
  • a transparent conductive film can be formed by applying a conductive polymer such as PEDOT (poly (3,4-ethylenedioxythiophene)) instead of ITO.
  • a substrate using silver nanowires as a conductive material
  • a substrate using silver nanoparticles a copper nanoparticle
  • a substrate using a highly conductive organic semiconductor material and the like.
  • the resistance of the electrode may be lowered by forming a film.
  • the column of “Light emitting layer” in the above-mentioned “biologically applied light irradiation device that can visually recognize that at least a part of the plastic sheet is shining” can be referred to.
  • the light emitting material can be selected according to the state of the disease of the living body to be applied. For example, blue light of about 400 to 500 nm may be effective for skin diseases such as skin cancer and acne. Therefore, when the bioapplied light irradiation device of the encapsulant of the present invention is used for the treatment of such skin diseases, it is preferable to use a light emitting material having a light emission maximum at 400 to 500 nm.
  • a photochemotherapeutic agent When a photochemotherapeutic agent is used in combination, it is preferable to use a luminescent material having an emission maximum at 500 to 700 nm, which is absorption of a porphyrin derivative produced in the body.
  • a luminescent material having an emission maximum at 500 to 700 nm which is absorption of a porphyrin derivative produced in the body.
  • a light emitting material having a light emission maximum in a long wavelength region of 600 nm or longer in order to irradiate light from outside the body and to penetrate deeply into the body, it is preferable to use a light emitting material having a light emission maximum in a long wavelength region of 600 nm or longer, and to avoid absorption by water existing in living tissue, 1200 nm. It is preferable to use a light emitting material having a light emission maximum in a range up to about.
  • the material of the light emitting layer may be a high molecular compound or a low molecular compound.
  • the low molecular compound may be a coating type low molecular compound or a low molecular compound that can be vacuum-deposited.
  • the polymer compound include a polymer-based red phosphorescent light emitting material manufactured by Sumitomo Chemical Co., Ltd.
  • the coating type low molecular weight compound include 1,3-bis (carbazol-9-yl) benzene (mCP).
  • mCP should be used in combination with a red phosphorescent material (Bis (2-benzo [b] thiophene-2-yl-pyridine) (acetylacetonate) iridium (III), (Ir (btp) 2 (acac))) or the like as a dopant.
  • a red phosphorescent material Bis (2-benzo [b] thiophene-2-yl-pyridine) (acetylacetonate) iridium (III), (Ir (btp) 2 (acac))
  • CBP having a structure described later can be exemplified.
  • CBP can be used in combination with Ir (ppy) 3 having a structure described later as a dopant.
  • the EL-type phosphor layer may have, that is, an injection layer, a blocking layer, a hole blocking layer, an electron blocking layer, an excitation blocking layer, a hole transport layer, and an electron transport layer
  • an injection layer a blocking layer
  • a hole blocking layer a hole blocking layer
  • an electron blocking layer an excitation blocking layer
  • a hole transport layer a hole transport layer
  • an electron transport layer a layer of the above-mentioned “biologically applied light irradiation device that can visually recognize that at least a part of the plastic sheet is shining”
  • the light-emitting element has a light-emitting layer sandwiched between electrodes, and an electrode (substrate-side electrode) positioned between the substrate and the light-emitting layer, It is preferable to further have a metal layer in between. This is due to the following reason. That is, it is preferable that the bio-applied light irradiation device using a flexible substrate such as a PEN substrate suppresses deterioration even when the light emission time is several hours.
  • the metal layer functions as a waterproof layer that prevents moisture from entering the light-emitting layer. Can be suppressed.
  • the bio-applied light irradiation device is attached to the skin of a living body to emit light, the living body's skin sweats.
  • the structure having a metal layer further effectively shields moisture originating from sweat together with moisture originally contained in the substrate, thereby minimizing the adverse effects of moisture on the organic semiconductor layer, quantum dot layer and cathode.
  • a silver or aluminum film is preferably used as the metal layer (metal layer disposed between the substrate-side electrode and the substrate) laminated on the substrate.
  • chromium for the base.
  • an alloy in which silver or aluminum and another metal are combined can be used.
  • the metal layer is preferably a metal thin film, and more preferably has a thickness of 3 nm to 20 nm.
  • the metal sealing film is provided as necessary.
  • the metal sealing film protects the light emitting element and also functions as a heat radiating plate that radiates heat generated in the light emitting element to the outside.
  • the upper surface and the side surface of the light emitting element 217 are covered with a fill material 210, and a metal sealing film 212 is provided so as to cover the fill material 210.
  • a sealing adhesive 211 seals between the lower end of the stop film 212 and the surface of the substrate 202.
  • the living body-applied light irradiation device included in the sealing body of the present invention has, for example, a light emitting element 217 only on one surface side of a substrate 202, as shown in FIG.
  • the surface and the side surfaces of the light emitting element 217 are preferably sealed with the metal sealing film 211 from the viewpoint of avoiding low-temperature burns of a living body to which the living body-applied light irradiation device is applied.
  • low temperature burns will be injured at 44 ° C for 3-4 hours or more at the contact part (Press Release from the National Institute of Technology and Evaluation, November 26, 2009 http: // www Nite.go.jp/jiko/chukanki/press/2009fy/091126.html).
  • Japanese Patent No. 4651281 states that the light irradiation intensity should be low, and the irradiation intensity is described as 1 to 10 mW / cm 2 .
  • the fact that the irradiation intensity is weak requires that the light is continuously applied for a long time, and the user is forced to wear the light irradiation device for a long time. Further, as shown in FIG. 1 of Japanese Patent No.
  • the irradiation intensity is 3 mW / cm 2 in a bio-applied light irradiation device having complete flexibility using a flexible substrate by sealing with a metal sealing film as described above. As described above, the surface temperature of the skin can be reduced to less than 44 ° C.
  • the irradiation intensity is 3 to 80 mW / cm 2 , particularly 10 to 50 mW / cm 2 by providing a sealing film made of a metal film such as aluminum foil on the opposite side of the living body application light irradiation device that contacts the skin. Even if light is emitted at cm 2 , the temperature of the light emitting part can be kept at 44 ° C. or lower, so that it can be used without worry by avoiding low-temperature burns, and the skin wearing time can be shortened.
  • the metal film used for the metal sealing film is not limited to a metal film made of a single metal, and may contain components other than metal as long as heat radiation can be efficiently performed. Moreover, you may substitute with the material which can thermally radiate efficiently instead of a metal film.
  • the side surface of the substrate is not sealed with a metal sealing film from the viewpoint of manufacturing a biologically applicable light irradiation device at low cost.
  • the sealed body of the light application device for living body of the present invention even when the side surface of the flexible substrate is not sealed, the light irradiation characteristics are deteriorated when stored for a long time in a high temperature and high humidity environment. Can be suppressed.
  • the sealing adhesive that seals between the metal sealing film and the substrate is not particularly limited, but it is preferable to select and use an adhesive having a large water and oxygen barrier property.
  • Commercially available products of such adhesives include, for example, UV (Ultraviolet) curable epoxy resin (TB3124M manufactured by Three Bond Co., Ltd.) having a high water and oxygen barrier property, and OleDry-F (Aure Dry F) manufactured by Futaba Electronics Co., Ltd. ( Product name), Molesco's moisture cut (product name), and the like.
  • the sealing film which mixed the moisture proofing agent by Ajinomoto Fine Techno Co. can be used preferably.
  • the adhesive material layer is provided in at least one part of the biological application surface of a board
  • the adhesive material layer is a layer formed by applying an adhesive material to the biological application surface of the substrate.
  • an area where the adhesive material layer is provided in the living body application surface may be referred to as an “adhesion area”.
  • the adhesive material layer is preferably 1 to 10 mm, more preferably 1 to 5 mm, and more preferably 1 to 3 mm.
  • an adhesive tape When forming such an adhesive region using a commercially available adhesive tape, it is preferable to cut out the central portion of the adhesive tape so that the adhesive tape does not cover the light emitting portion.
  • the adhesive tape using a silicone type adhesive other than a normal commercially available adhesive tape can be used.
  • An adhesive tape using a silicone-type adhesive is particularly preferably used for the bio-applied light irradiation device of the present invention because it is easy to reattach.
  • the living body application light irradiation device included in the sealing body of the present invention may have a light extraction improving film on the living body application surface of the substrate 202 as necessary. Thereby, the light irradiation efficiency to a biological body can be improved.
  • the light extraction improving film is only required to be disposed on at least the light emitting portion of the living body application surface, and is preferably disposed in a region coincident with the light emitting portion.
  • a photochemotherapeutic agent layer is a layer which consists of a chemotherapeutic agent, for example, can be provided by apply
  • the photochemotherapeutic agent layer should just be distribute
  • the photochemotherapeutic agent is not particularly limited, and examples thereof include those containing 5-aminolevulinic acid (also referred to as 5-ALA) as an active ingredient. It has been studied that 5-aminolevulinic acid accumulates in cancer cells and is metabolized to protoporphyrin IX, which acts as a photosensitive substance. In addition to 5-aminolevulinic acid, various known photosensitizers can be used. Specifically, APCastane et al., Photodiagnosis Photodyn Ther., 2004, vol. 1 p279; R. Bonnell, Chem. Soc. Rev., 1995, v. 24, p19; JCKennedy et al., Photochemistry and Photobiology B: Biology, 1992, v.14, p275. However, photochemotherapeutic agents that can be used in the present invention are not limited to these.
  • a protective film When providing the above-mentioned adhesive material layer or photochemotherapy agent layer on the biological application surface of the bioapplied light irradiation device, a protective film can be laminated on the adhesive material layer or photochemotherapy agent layer as necessary. preferable. In this case, the user can perform treatment by peeling off the protective film before using the living body-applied light irradiation device to expose the surface of the adhesive material layer or the photochemotherapy agent layer, and sticking the surface to the affected area. it can. That is, treatment by photodynamic therapy can be easily started without separately applying a photochemotherapy cream to the affected area.
  • the organic layer included in the light-emitting element that is an organic semiconductor can be formed by coating or vapor deposition.
  • a metal layer such as an electrode included in the light emitting element and other inorganic layers can also be formed by coating or vapor deposition.
  • a method for producing an organic EL element a known method such as a generally known vacuum deposition method, ink jet method, screen printing method, flexographic printing method, or the like can be used.
  • the coating method include known methods such as spin coating.
  • each layer may be formed by sputtering or the like.
  • the light-emitting element is not limited to the above multilayer organic semiconductor structure. There is no particular limitation as long as electrons and holes are combined to generate an excited state in the light emitting layer, and the light emitting layer can emit light.
  • a bio-applied light irradiation device need not be manufactured in an inert atmosphere. Manufacturing in an air atmosphere can be manufactured at a lower cost than when manufacturing in an inert atmosphere.
  • the sealing body of the biologically applied light irradiation device of the present invention has the biologically applied light irradiation device inside the protective bag, and the protective bag has a metal layer. With such a configuration, it is preferable that the biologically applied light irradiation device is shielded from the outside air.
  • a light emitting element including an organic semiconductor or quantum dots formed on a flexible substrate can be used for long-term storage in a high temperature and high humidity environment without using a flexible substrate on which a special barrier film is formed. Deterioration of irradiation characteristics can be suppressed.
  • a defect causes the generation of a so-called dark spot when the living body applied light irradiation device emits light, and the living body applied light irradiation device has a large non-light emitting portion.
  • a bio-applied light irradiating device not only has a small light emitting area, but also a current concentrates on a small part of the light emitting element, and the light emitting element is destroyed as soon as it reaches a high temperature. Even if the bio-applied light irradiating device having such a light emitting element is applied to a living body, naturally, the integrated irradiation amount becomes insufficient, and the expected therapeutic effect and beauty effect cannot be obtained.
  • the metal layer of the protective bag is preferably an aluminum layer.
  • the protective bag is preferably an aluminum moisture-proof bag.
  • the metal layer is preferably coated with an insulating material such as a polymer, and an antistatic layer is preferably provided.
  • a commercially available product may be used as the aluminum moisture-proof bag.
  • moisture-proof bags made by Richmond technology, Inc., Maruai Co., Ltd., or ET Corporation are commercially available. Among these, it is preferable to use a product manufactured by Richmond technology, INC (particularly ML-131 T-1) as a protective bag.
  • the water vapor transmission rate of the protective bag is preferably 1 ⁇ 10 ⁇ 4 g / m 2 / day or less, more preferably 1 ⁇ 10 ⁇ 5 g / m 2 / day or less, and 1 ⁇ 10 ⁇ 4 g / m 2 / day or less. It is particularly preferably 10 ⁇ 6 g / m 2 / day or less.
  • the protective bag conforms to the MIL (Military Specifications and Military Standards) standard which is a US military standard.
  • the protective bag further has an insulating layer from the viewpoint of avoiding unintentional short-circuiting of the bio-applied light irradiation device inside the protective bag.
  • the insulating layer is preferably coated on the metal layer.
  • the sealing body of the biological application light irradiation device of this invention has a desiccant further inside the protective bag.
  • the position of the desiccant 305 inside the protective bag is not limited to the position shown in FIG.
  • the protective bag shows the biological application light irradiation device taking-out cutting part 304 in FIG. 6 so that the user can discriminate.
  • a straight line or a character may be drawn on the biological application light irradiation device extraction cutting unit 304.
  • a cutout may be made at a position (for example, an end portion) that does not impair the sealing performance of the protective bag so as to overlap a part of the cutting portion 304 for taking out the living body applied light irradiation device.
  • the user tear the protective bag before use and attach the bio-applied light irradiation device to the irradiated site (for example, the affected part).
  • the protective bag is torn, it is preferable to break the biological application light irradiation device taking-out cutting part 304 in FIG. 6 of the protective bag.
  • the treatment can be started by connecting to a power source and turning on the switch.
  • connection between the bio-applied light irradiation device and the power source reference can be made to the column “Usage Mode of Bio-Applied Light Irradiation Device” described later.
  • the manufacturing method of the sealing body of the biological application light irradiation device of the present invention includes a sealing step of sealing the biological application light irradiation device in a protective bag,
  • the biological application light irradiation device has a substrate and a light emitting element,
  • the board is a flexible board,
  • the light emitting element comprises an organic semiconductor or quantum dots;
  • the protective bag has a metal layer.
  • the sealing step is preferably performed in an atmosphere with a relative humidity of 30% or less, more preferably in an atmosphere with a relative humidity of 20% or less. It is particularly preferable to carry out in an atmosphere of 10% or less.
  • the sealing step does not require sealing in an inert atmosphere. Sealing in an air atmosphere can be cheaper than sealing in an inert atmosphere. It is preferable to perform the sealing step while vacuum degassing.
  • the sealing portion 303 is sealed by heat sealing or the like after the biological application light irradiation device 302 is put in the protective bag 301 as shown in FIG. It is preferable to perform the sealing step after further adding a desiccant to the inside of the protective bag.
  • the method of using the sealing body for a bio-applied light irradiation device according to the present invention includes a sealing body for a bio-applied light irradiation device using a sealing body for a bio-applied light irradiation device having a bio-applied light irradiation device inside a protective bag.
  • a sealing body for a bio-applied light irradiation device using a sealing body for a bio-applied light irradiation device having a bio-applied light irradiation device inside a protective bag.
  • Attach the living body application light irradiation device taken out of the protective bag to the living body and make the light emitting part emit light The biological application light irradiation device has a substrate and a light emitting element,
  • the board is a flexible board,
  • the light emitting element comprises an organic semiconductor or quantum dots;
  • the protective bag has a metal layer.
  • the light emitting element is connected to a power source, and electricity is supplied from the power source to cause the light emitting element to emit light.
  • the method of using the sealing body for a bio-applied light irradiation device according to the present invention has an adhesive material on at least a part of the surface of the substrate on which the light emitting element is not formed. It is preferable to fix to the skin. For details of other methods of use, reference can be made to the description of “Usage Mode of Sealed Body of Living Body Light Irradiation Device” described later.
  • the bio-applied light irradiation device of the present invention and the bio-applied light irradiation device of the sealing body of the present invention can be regarded as a capacitor basically composed of a thin film of an organic compound that is an insulator. Therefore, when a voltage is first applied, charging as a capacitor is performed. Therefore, depending on the situation, it is preferable to take measures to avoid the risk of dielectric breakdown or short circuit due to excessive current.
  • One way to achieve this is to increase or decrease the voltage step by step.
  • the aspect described in Japanese Patent Application Laid-Open No. 2012-82121 can be used for the biologically applied light irradiation device of the present invention.
  • the organic EL is a mechanism that emits light by recombination of holes and electrons injected from an electrode in the light emitting layer, brightness changes depending on a flowing current. That is, since it can be said to be a current drive system, a constant current circuit is almost always used for illumination and display applications.
  • constant voltage driving when the driving is continued for a long time, the resistance of the organic EL light emitting section generally increases gradually and the driving current tends to decrease.
  • the living body applied light irradiation device of the present invention as a so-called disposable living body applied light irradiation device that is limited to one-time use, it does not require a long light emission life, so that it does not become a big problem. .
  • the living body applied light irradiation device of the present invention it is also possible to suppress heat generation by performing pulse driving. It is also possible to perform reverse bias at the start of driving, or drive by combining a positive bias and a reverse bias at the time of pulse driving. In the present invention, it is possible to appropriately select and employ these driving methods in accordance with the use mode and purpose of use.
  • the living body applied light irradiation device of the present invention can also be controlled to emit light in a desired time zone. For example, there is a case where light irradiation is required after allowing time for conversion to another substance after application to a patient, such as 5-ALA.
  • the living body applied light irradiation device of the present invention can be provided with a timer function so that it emits light after a desired time has elapsed.
  • control is preferably performed by a control program.
  • a control program For example, when 5-ALA is applied, it is preferable to control so that light emission starts 2 to 3 hours after application.
  • the biologically applied light irradiation device of the present invention and the biologically applied light irradiation device included in the sealing body of the present invention can be controlled to stop light emission after a desired time has elapsed.
  • a control program or a circuit that prevents the use of a once-applied biologically-applied light irradiation device can be built in the sense of preventing reuse after the treatment with light emission is completed.
  • the bio-applied light irradiation device of the present invention and the bio-applied light irradiation device of the sealing body of the present invention can be portable. In order to make it portable, it is preferable to use a device in which the power supply unit and the light irradiation unit are integrated, or to connect both with a cable for passing a current. These are preferably provided with sockets that can be easily connected so that the user can easily connect and remove the light irradiation section.
  • the bio-applied light irradiation device of the present invention includes a light emitting element including an organic semiconductor or quantum dots and a flexible substrate, and further includes a burn prevention mechanism.
  • a light emitting element including an organic semiconductor or quantum dots and a flexible substrate
  • a burn prevention mechanism for the description and preferred range of the light-emitting element and the flexible substrate including the organic semiconductor or the quantum dots, and specific examples of the constituent material, the corresponding description of the bio-applied light irradiation device included in the sealing body of the present invention can be referred to.
  • this bioapplied light irradiation device may be housed inside the protective bag or may not be housed inside the protective bag.
  • the burn prevention mechanism is a mechanism that blocks or attenuates light irradiation from the biologically applied light irradiation device before the biologically applied light irradiation device reaches a high temperature that causes burns to the living body.
  • a bio-applied light irradiation device including a burn prevention mechanism will be described.
  • “a high temperature that causes burns to a living body” is referred to as “burn generation temperature”.
  • the living body-applied light irradiation device of the first embodiment includes a constant current circuit that drives a light emitting element and a burn prevention mechanism that reduces output when the voltage of the constant current circuit falls below a specific value.
  • the principle of preventing burns by this burn prevention mechanism is as follows. In other words, in a bio-applied light irradiation device in which the light-emitting element includes an organic semiconductor or quantum dots, a constant correlation between the device temperature and the driving voltage during constant current driving is that the driving voltage decreases as the device temperature increases. Is seen.
  • the fact that the voltage of the constant current circuit is not more than a specific value means that the device temperature is not less than the specific temperature. Therefore, in the above correlation, if the drive voltage when the device temperature is lower than the burn occurrence temperature is a specific value, and the output is reduced when the voltage of the constant current circuit falls below the specific value, It is possible to prevent the device temperature from becoming higher than the temperature at which the burn occurs, and thus it is possible to reliably prevent the burn of the living body.
  • the “specific value” as an output reduction index is preferably a drive voltage when the device temperature is 55 ° C. or less in the correlation between the device temperature and the drive voltage, and the device temperature is 45 ° C. or less.
  • a drive voltage at a certain time is preferable, and a drive voltage at a device temperature of 40 ° C. or lower is more preferable.
  • the correlation between the device temperature and the driving voltage is determined by, for example, leaving the biologically applied light irradiation device in a thermostat and adjusting the device to a constant temperature, and then adjusting the biologically applied light irradiation device to a constant current under actual use conditions.
  • the operation of driving and measuring the voltage of the constant current circuit can be obtained by performing a plurality of operations for each temperature near the burn occurrence temperature.
  • the reduction in output when the voltage of the constant current circuit falls below a specific value may reduce the magnitude of the current supplied to the light emitting element, or cut off the supply of current to the light emitting element. You may do.
  • FIG. 7 shows an example of a drive circuit included in the living body applied light irradiation device of the first embodiment.
  • 401 denotes a light emitting element
  • 402 denotes a voltage source
  • 403 denotes a constant current driving circuit (constant current circuit)
  • 404 denotes a comparator
  • 405 denotes a constant current driving cutoff circuit.
  • a constant current is supplied into the drive circuit by the operation of the voltage source 402 and the constant current drive circuit 403.
  • the comparator 404 and the constant current drive cut-off circuit 405 constitute a burn prevention mechanism, and a reference voltage is input to the comparator 404 in advance.
  • the reference voltage is a “specific value” of the voltage of the constant current circuit (a “specific value” used as an output reduction index).
  • the light emitting element 401 is driven by the current supplied from the constant current driving circuit 403, and the voltage of the constant current driving circuit 403 is input to the comparator 404.
  • the comparator 404 compares the input voltage with the reference voltage, and operates the constant current drive cutoff circuit 405 when the input voltage becomes equal to or lower than the reference voltage. Due to the operation of the constant current drive cut-off circuit 504, the supply of voltage from the constant current drive circuit 403 is cut off, and the drive of the light emitting element 401 is stopped.
  • the bio-applied light irradiation device of the second embodiment includes a constant voltage circuit that drives the light emitting element and a burn prevention mechanism that reduces the output when the current flowing through the light emitting element exceeds a specific value.
  • the principle of preventing burns by this burn prevention mechanism is as follows. In other words, in a bio-applied light irradiation device in which the light-emitting element includes an organic semiconductor or quantum dots, there is a certain correlation that the drive current increases as the device temperature increases between the device temperature and the drive current during constant voltage driving. Is seen.
  • the fact that the current flowing through the light emitting element is equal to or higher than a specific value means that the device temperature is equal to or higher than the specific temperature. Therefore, in the above correlation, if the current when the device temperature is less than the burn occurrence temperature is a specific value and the output is reduced when the current flowing through the light emitting element exceeds the specific value, the device It is possible to prevent the temperature of the burn from exceeding the temperature at which the burn occurs, and thus it is possible to reliably prevent the burn of the living body.
  • the “specific value” as an output reduction index is preferably a drive current when the device temperature is 55 ° C. or less in the correlation between the device temperature and the drive current, and the device temperature is 45 ° C. or less.
  • the drive current is at a certain time, and it is more preferable that the drive current is when the device temperature is 40 ° C. or lower.
  • the relationship between the device temperature and the drive current is determined by, for example, leaving the biologically applied light irradiation device in a thermostatic chamber and adjusting the device to a constant temperature, and then driving the biologically applied light irradiation device at a constant voltage under actual use conditions.
  • the operation of measuring the current of the constant current circuit can be obtained by performing a plurality of operations for each temperature in the vicinity of the burn occurrence temperature.
  • the reduction of the output when the current flowing through the light emitting element exceeds a specific value may reduce the magnitude of the voltage applied to the light emitting element, or cut off the voltage application to the light emitting element. You may do.
  • FIG. 8 an example of the drive circuit with which the biological application light irradiation device of 2nd Embodiment is provided is shown.
  • 401 denotes a light emitting element
  • 402 denotes a voltage source
  • 406 denotes a constant voltage drive circuit (constant voltage circuit)
  • 407 denotes a current detection / voltage conversion circuit
  • 408 denotes a comparator
  • 409 denotes a constant voltage drive cutoff circuit.
  • a constant voltage is applied to the light emitting element 401 by the operation of the voltage source 402 and the constant voltage driving circuit 406.
  • the current detection / voltage conversion circuit 407, the comparator 408, and the constant voltage drive cutoff circuit 409 constitute a burn prevention mechanism, and a reference voltage is input to the comparator 408 in advance.
  • the reference voltage is a “specific value” of current in the constant voltage circuit (“specific value” as an index for reducing output).
  • the light emitting element 401 is driven by the voltage applied from the constant voltage driving circuit 406, and the current flowing through the light emitting element 402 is detected by the current detection / voltage conversion circuit 407.
  • the current detection / voltage conversion circuit 407 converts the detected current into a voltage and outputs the voltage to the comparator 408.
  • the comparator 408 compares the input voltage with the reference voltage, and operates the constant voltage drive cutoff circuit 409 when the input voltage becomes equal to or higher than the reference voltage.
  • the constant voltage drive cut-off circuit 409 By the operation of the constant voltage drive cut-off circuit 409, the voltage application from the constant voltage drive circuit 406 is cut off, and the drive of the light emitting element 401 is stopped.
  • the bio-applied light irradiation device of the third embodiment has an adhesive region for sticking the bio-applied light irradiation device to the living body, and the adhesive force of the adhesive region is lowered at a specific temperature or higher, and the device is applied from the living body. It is equipped with a mechanism to prevent burns. According to this burn prevention mechanism, the living body applied light irradiation device falls off the living body above a specific temperature, so that the living body applied light irradiation device having a temperature higher than the specified temperature can be held in close contact with the living body. Absent.
  • the device can be removed from the living body before the bio-applied light irradiation device exceeds the burn generation temperature. In this way, it is possible to reliably prevent the burn of the living body.
  • the specific temperature at which the adhesive strength of the adhesive region decreases is preferably 55 ° C. or less, more preferably 50 ° C., and further preferably 45 ° C.
  • the adhesive region is a temperature-sensitive adhesive tape that gives a temperature-sensitive adhesive material whose adhesive strength decreases at a specific temperature or higher, or a temperature-sensitive adhesive tape whose adhesive strength decreases at a specific temperature or higher. Can be formed by sticking to the living body application surface.
  • thermosensitive adhesive tape examples include a double-sided adhesive tape (Intellimer tape, warm-off type model number WS5130C02) manufactured by Nitta Corporation and a temperature-sensitive adhesive tape described in JP-A No. 2000-351946. it can.
  • the bio-applied light irradiation device of the present invention (a bio-applied light irradiation device that can visually recognize that at least a part of the plastic sheet is shining, a bio-applied light irradiation device having a burn prevention mechanism), and the sealing body of the present invention
  • the usage mode of the bio-applied light irradiation device possessed by is described.
  • the biologically applied light irradiation device of the present invention and the biologically applied light irradiation device of the sealing body of the present invention are collectively referred to as “biologically applied raw light irradiation device”.
  • FIG. 9 shows a schematic diagram of an example of a usage mode of the bio-applied light irradiation device.
  • the biological application light irradiation device 101 shown in FIG. 9 is connected to the intermediate connector 102 by the wiring 215 (lead wire extending from the substrate) of the biological application light irradiation device.
  • a power supply wiring 104 (lead wire) is extended and connected from the intermediate connector 102 to the power supply 103.
  • the sealing body light irradiation device shown in FIG. 5 is connected to the power source 103 as the biological application light irradiation device 101, the wiring extraction pad 213 is connected to the anode 204 via the metal layer 201, The wiring 215 is connected to the wiring extraction pad 213 through the conductive adhesive 214.
  • the living body application light irradiation device includes the wiring extraction pad 213 and the wiring extraction pad connected to the cathode 209. Is also preferably provided.
  • the 1 can also connect the anodes 11 and 21 to the conductive 215 by the same connection structure as shown in FIG.
  • a wiring extraction pad connected to the anode and also a wiring extraction pad connected to the cathodes 16 and 23 in this living body applied light irradiation device.
  • the wiring 215 of the living body applied light irradiation device include FPC (Flexible Printed Circuits) and normal conductive wires, but it is preferable to use FPC.
  • the FPC can be connected by applying a conductive adhesive to the wiring extraction pad and thermocompression bonding the FPC.
  • the conductivity can be connected to the wiring take-out pad by soldering.
  • the wiring connection is not limited to the above method, and can be performed using a known method.
  • the bio-applied light irradiation device used in the present invention is not limited to the usage mode shown in FIG.
  • the living body applicable light irradiation device 101 and the power source 103 are directly connected only by the wiring 215 of the living body applicable light irradiation device or only by the wiring 104 of the power source without using the intermediate connector 102. Also good.
  • the living body applied light irradiation device 101 and the power source 103 are directly connected, the living body applied light irradiation device may be sealed and set in a state in which the power source is connected to the living body applied light irradiation device.
  • the biological application light irradiation device 101 and the power source 103 are separable.
  • the intermediate connector 102 when the intermediate connector 102 is not used, it is more preferable to provide a connector part (not shown) in the living body applied light irradiation device and connect the power supply wiring 104 to the connector part.
  • the power supply 103 supplies electric power to the biological application light irradiation device 101.
  • the bio-applied light irradiation device is preferably portable, and the power source 103 preferably has a built-in secondary battery (not shown) that can be repeatedly charged for portable use.
  • the power source is preferably provided with a booster circuit, a timer, and the like (not shown), and it is preferable to perform various controls such as light emission time and luminance.
  • the power supply has an overcurrent protection circuit (not shown) so that a large current flows when the bio-applied light irradiation device is short-circuited to heat the light-emitting element and the user does not get burned. It is preferable.
  • Organic semiconductors or quantum dots can be easily powered by a portable low voltage power supply.
  • the temperature of the element can be detected by utilizing the temperature change of the current-voltage characteristic of the organic semiconductor element, and the element can be used as a heating prevention sensor for the element.
  • the bio-applied light irradiation device may be a portable unit including all of them or may include a built-in power source.
  • the living body applied light irradiation device can be used in a state where the user can freely move around.
  • the bio-applied light irradiation device can be removed at the convenience of the user, and can be used on the go such as at home or work. This brings great convenience to the user.
  • Bio-applied light irradiation devices are easy to handle and may be used without the presence of medical or beauty professionals.
  • the bio-applied light irradiation device is for medical use or cosmetic use.
  • the power source 103 is preferably provided with a display 106. It is preferable that the display is provided with functions such as setting of treatment time by the user, confirmation of charging status of the secondary battery, confirmation of elapse of light emission time, confirmation of temporary stop when light emission is interrupted halfway.
  • the living body and the application method to which the living body applied light irradiation device is applied will be described.
  • Examples of the living body to which the living body applied light irradiation device is applied include humans and animals. Examples of animals include mammals.
  • the light emitted from the living body applied light irradiation device may be applied to any part of the living body.
  • irradiation can be performed on feet, shoulders, arms, hands, head, face, abdomen, back, and the like. Irradiation is possible not only for the skin but also for diseases such as brain tumors.
  • the light emitted from the living body applied light irradiation device is applied to the skin of the living body. Furthermore, it is more preferable that the light emitted from the living body applied light irradiation device is irradiated to the skin of a specific affected part of the living body or the skin near the affected part.
  • the bio-applied light irradiation device 101 usually has a light emitting unit 218.
  • an adhesive material 201 to be attached to the living body is formed around the light emitting unit 218.
  • the living body applied light irradiation device used in the present invention is not limited to the usage mode shown in FIG. 9, and is not provided with the adhesive material 201 for mounting on the living body, and from above the living body applied light irradiation device 101.
  • the periphery or the whole of the device may be covered with an adhesive material such as surgical tape and attached to a living body.
  • the living body applied light irradiation device may be attached to any part of the living body. It can be worn on the feet, shoulders, arms, hands, head, face, abdomen, back, etc.
  • the bio-applied light irradiation device can be shaped according to the attachment site of the living body.
  • the bio-applied light irradiation device can have a shape that makes one round around the arm or a shape that makes one round around the wrist like a wristwatch.
  • the bio-applied light irradiation device may be a flexible film covering a large area such as a compress.
  • the biologically applied light irradiation device is attached to a linear scar, wrinkle or the like, it is preferable to have an elongated linear shape.
  • the bio-applied light irradiation device when applied to an organ such as the heart or lung, it may have a shape that matches the shape of the organ.
  • the bio-applied light irradiation device includes a circular shape, an elliptical shape, a square shape, a rectangular shape, and the like.
  • the bio-applied light irradiation device used in the present invention is flexible, it can be used by being curved by the user according to the shape of an arbitrary living body.
  • the temperature at the time of light emission of the biologically applied light irradiation device is preferably less than 45 ° C, more preferably less than 44 ° C, and particularly preferably less than 42 ° C.
  • the bio-applied light irradiation device of the present invention (a bio-applied light irradiation device capable of visually recognizing that at least a part of the plastic sheet is shining, a bio-applied light irradiation device having a burn prevention mechanism), and the sealing body of the present invention
  • the bio-applied light irradiation device possessed by can be effectively used for treatment and beauty of the living body.
  • diseases that can be treated include skin diseases and internal diseases.
  • premalignant diseases malignant diseases, and inflammatory skin diseases can be mentioned.
  • pre-malignant skin diseases include Bowen's disease, actinic keratosis, arsenic keratosis, Paget's disease, and radioactive dermatitis.
  • Malignant diseases include all types of basal cell carcinoma, squamous cell carcinoma, secondary metastasis, cutaneous T-cell lymphoma.
  • Inflammatory skin diseases include all types of dermatitis and psoriasis.
  • Other examples of treatable diseases include primary and metastatic tumors, as well as inflammatory diseases such as connective tissue diseases, all types of arthritis, inflammatory bowel diseases.
  • JP 2013-513555 A the diseases described in JP 2013-513555 A can also be mentioned.
  • the mechanism by which the above-mentioned diseases can be treated by phototherapy is known (for example, see CANCER June 15, 1997 / Volume 79 / Number 12, p2282). These diseases can be treated with light emitted from the bio-applied light irradiation device used in the present invention.
  • PDT photodynamic therapy
  • a photosensitive therapeutic agent known as a photopharmacological agent
  • the region is treated with light of the appropriate frequency and intensity.
  • photochemotherapeutic agent A variety of photochemotherapeutic agents are currently available (see, for example, US Pat. No. 4,651,281 [0002]).
  • bio-applied light irradiation device of the present invention and the bio-applied light irradiation device of the sealing body of the present invention can be used alone for medical use or cosmetic use, as well as in skin disease treatment apparatuses and cosmetic treatment apparatuses. Or it can use effectively also as a light irradiation part which irradiates light to the object of cosmetic treatment.
  • Skin diseases for which the treatment apparatus for skin diseases having this bio-applied light irradiation device is particularly effective include actinic keratosis, Bowen's disease, superficial basal cell carcinoma, confirmation of cancer cells excised in addition to skin diseases, acne Examples include improvement, improvement of insomnia, improvement of depression, improvement of juxus, early recovery of trauma, and prevention of infection by Staphylococcus aureus because no resistant bacteria are produced when light is used.
  • the cosmetic treatment apparatus having this bio-applied light irradiation device can be effectively used particularly for skin beauty. Examples of cosmetic purposes for which the bio-applied light irradiation device of the present invention is particularly effective include relief of spots and wrinkles, improvement of skin elasticity, and removal of moles.
  • the present invention can also provide a method for storing a bio-applied light irradiation device.
  • the biologically applied light irradiation device is preferably not in contact with gas outside the protective bag.
  • the method for preserving the living body applied light irradiation device preferably stores the sealed body of the living body applied light irradiation device in an air environment.
  • the sealed body of the light application device for living body of the present invention can be stored for a long time in a high temperature and high humidity environment.
  • the light irradiation characteristics when the sealed body is left for 2 weeks at 60 ° C. and 90% relative humidity. Deterioration can be suppressed.
  • the sealing body of the light application device for living body of the present invention can be stored for a long time in a high-temperature and high-humidity environment, it is not necessary to store it in an inert atmosphere (for example, nitrogen or argon).
  • deterioration of light irradiation characteristics can be suppressed even when stored for a long time in an active atmosphere containing water or oxygen such as in the air. It is cheaper to store in an air atmosphere than to store in an inert atmosphere. Moreover, it is also preferable to add a desiccant further inside the protective bag as described above.
  • the set of the present invention is a set having a power source and a sealing body of a biological application light irradiation device having a biological application light irradiation device inside a protective bag,
  • the biological application light irradiation device has a substrate and a light emitting element,
  • the board is a flexible board,
  • the light emitting element comprises an organic semiconductor or quantum dots;
  • the protective bag has a metal layer.
  • This bio-applied light irradiation device is the bio-applied light irradiation device of the present invention (a bio-applied light irradiation device that can visually recognize that at least a part of a plastic sheet is shining, or a bio-applied light irradiation device having a burn prevention mechanism). May be. Since the set of the present invention has a power source and a sealing body for a bio-applied light irradiation device having a bio-applied light irradiation device inside the protective bag, the user removes the bio-applied light irradiation device from the protective bag. It can be connected to a power supply immediately and is highly convenient.
  • the set of the present invention After using the set of the present invention, only the biologically applied light irradiation device may be discarded. That is, after the light irradiation, the living body applied light irradiation device attached to the affected part can be peeled off, the wiring (cord) connected to the power supply can be removed, and only the living body applied light irradiation device can be discarded.
  • the set of the present invention replaces only the sealed body of the bio-applied light irradiation device of the present invention included in the set with the separately obtained sealed body of the bio-applied light irradiation device of the present invention. It is preferable to use it repeatedly.
  • the evaluation of the light emission characteristics was performed by using a source meter (manufactured by Keithley: 2400 series), a semiconductor parameter analyzer (manufactured by Agilent Technologies: E5273A), an optical power meter measuring device (manufactured by Newport: 1930C), an optical spectrometer. (Ocean Optics, USB2000), spectroradiometer (Topcon, SR-3) and streak camera (Hamamatsu Photonics C4334) were used.
  • a biologically applied light irradiation device having an organic EL element was produced by the following procedure.
  • a schematic diagram of the bio-applied light irradiation device manufactured in Example 1 is shown in FIG.
  • the bio-applied light irradiation device manufactured in Example 1 has a metal layer 203 further between the electrode (anode 204) positioned between the substrate 202 and the light emitting layer 207 and the substrate 202.
  • a PEN film containing polyethylene naphthalate (PEN) having a size of 40 mm square and a thickness of 80 ⁇ m as a main component was used as the flexible substrate.
  • the water vapor permeability of the used PEN film was 1 ⁇ 10 ⁇ 6 g / m 2 / day or less.
  • a metal layer 203 was formed on the substrate 202 by sputtering a silver thin film, which is a continuous film having a thickness of 15 nm, to 30 mm ⁇ 30 mm.
  • the transmittance of the obtained metal layer at a wavelength of 630 nm was about 40%.
  • a light emitting element including the anode 204, the hole injection layer 205, the interlayer 206, the light emitting layer 207, the electron injection layer 208, and the cathode 209 was formed by the following procedure.
  • the formed light-emitting element is a light-emitting element (organic EL element) containing an organic semiconductor.
  • An anode 204 was formed on the metal layer 203 by sputtering indium tin oxide (ITO) with a thickness of 20 nm. In a glove box adjusted to a nitrogen atmosphere, Nissan Chemical L-source was spin coated on the anode 204 and baked at 150 ° C. for 10 minutes to form a hole injection layer 205.
  • ITO indium tin oxide
  • a 20 nm spin-coated thermally-crosslinked polymer material made by Sumitomo Chemical dissolved in xylene is spin-coated on the hole injection layer 205 and baked at 160 ° C. to form an interlayer 206.
  • a high-molecular red phosphorescent material made of Sumitomo Chemical dissolved in xylene was applied in the same manner to a thickness of 70 nm on the interlayer 206 and baked at 160 ° C. to form a light emitting layer 207.
  • the stacked body on which the light emitting layer 207 was formed was put into a vacuum vapor deposition machine, and 1 nm of lithium fluoride was deposited on the light emitting layer 207 to form an electron injection layer 208. Subsequently, aluminum was deposited to 120 nm on the electron injection layer 208 in a vacuum deposition machine to form a cathode 209.
  • the biologically applied light irradiation device thus formed has a light emitting element only on one surface side of the substrate.
  • the obtained organic EL device was transferred from the vacuum vapor deposition machine to the glove box, and an insulating adhesive (CELVENUS manufactured by Daicel Corp.) was used as the fill material 210 and applied to the entire light emitting portion (organic EL device) with a dispenser. Further, a UV (Ultraviolet) curable epoxy resin (TB3124M manufactured by ThreeBond Co., Ltd.) having a high water and oxygen barrier property is applied as an adhesive 211 for sealing around the organic EL element, and an insulating property having a thickness of 0.1 mm is formed as a metal film 212. Covered with aluminum foil.
  • an insulating adhesive CELVENUS manufactured by Daicel Corp.
  • the back surface of the metal film 212 was irradiated with UV and heated at 150 ° C. to cure the sealing adhesive 211.
  • the side surface of the substrate 202 is not sealed with the metal film 212 (metal sealing film).
  • the light emitting part 218 of the obtained organic EL element was 30 mm ⁇ 30 mm.
  • a silver paste was applied to desired positions of the anode and the cathode to form a wiring extraction pad 213.
  • a conductive adhesive 214 was applied to the wiring take-out pad, and the wiring 215 of the bio-applied light irradiation device, which is an FPC (Flexible printed circuit), was connected by thermocompression bonding.
  • an aluminum moisture-proof bag (Richmond technology, manufactured by INC, trade name: ML-131 T-1) was prepared.
  • the aluminum moisture-proof bag used had an aluminum layer and an insulating layer coated thereon.
  • the water vapor transmission rate of the aluminum moisture-proof bag used was 1 ⁇ 10 ⁇ 6 g / m 2 / day or less.
  • the living body applied light irradiation device was sealed inside the protective bag.
  • the produced biologically applied light irradiation device 302 and a desiccant 305 (manufactured by Uptec Japan Co., Ltd., trade name Dreiflex) were placed inside the protective bag 301 in an atmosphere with a relative humidity of 30% or less. Then, the sealing part 303 was sealed by heat-sealing so that the bio-applied light irradiation device did not come into contact with the gas outside the protective bag. Thus, the sealing body of the biological application light irradiation device of Example 1 was produced.
  • the irradiation intensity of the light emitting element of the sample for evaluation was 30 mW / cm 2 .
  • the biological application light irradiation device which is the sample for evaluation, could continue to emit light for 10 hours.
  • it can be easily applied to a living body with many curved surfaces, can be used for a disposable device, is inexpensive, and has light irradiation characteristics when stored for a long time in a high temperature and high humidity environment. It turned out that the sealing body of the biological application light irradiation device which can suppress deterioration of can be provided.
  • Comparative Example 1 For the evaluation of Comparative Example 1, the biologically applied light irradiation device produced in Example 1 was left in a protective bag for 60 days at a temperature of 90 ° C. and a relative humidity of 90% for 2 weeks, and then returned to room temperature. Samples were prepared. As a result of evaluating the characteristics of the evaluation sample of Comparative Example 1 in the same manner as in Example 1, the evaluation sample of Comparative Example 1 emitted only a small part of the light emitting surface of the light emitting element.
  • Example 2 As a material of the light-emitting layer 207, 1,3-bis (carbazol-9-yl) benzene (mCP) dissolved in xylene is used as a red phosphorescent material (Bis (2-benzo [b] thiophene-2-yl) used as a dopant. -pyridine) (acetylacetonate) iridium (III ), (Ir (btp) 2 (acac))) was added 5 wt% of mCP, to prepare a coating-type low-molecular compound solution.
  • Example 1 a biologically applicable light irradiation device was formed in the same manner as in Example 1 except that the light emitting layer 207, the electron injection layer 208, and the cathode 209 were formed by the following method. Specifically, the light emitting layer 207 was spin-coated with the above-described coating type low molecular compound solution, and the film thickness was adjusted to 30 nm to form a film. Subsequently, Tris (8-quinononate) aluminum (Alq3) was vacuum-deposited by 20 nm as an electron transport material to form an electron injection layer 208. Then, 1 nm of lithium fluoride was vapor-deposited, aluminum was vapor-deposited, and it was set as the cathode 209.
  • Tris (8-quinononate) aluminum Alq3
  • a sealed body for a bio-applied light irradiation device was formed in the same manner as in Example 1 except that the obtained bio-applied light irradiation device was used. Moreover, the sample for evaluation of Example 2 was produced using the sealing body of the biological application light irradiation device of Example 2 like Example 1. FIG. As a result of evaluating the characteristics of the evaluation sample of Example 2, the evaluation sample of Example 2 had the same tendency as in Example 1.
  • Example 3 In Example 1, instead of forming the anode 204, the hole injection layer 205, the interlayer 206, the light emitting layer 207, the electron injection layer 208, and the cathode 209, an organic EL element having the following layer structure is formed by vacuum deposition in a vacuum chamber. A bio-applied light irradiation device was formed in the same manner as in Example 1 except that it was formed.
  • FIG. 10 shows an emission spectrum of the bio-applied light irradiation device produced in Example 3. From FIG. 10, it was found that the bio-applied light irradiation device produced in Example 3 had the maximum emission wavelength of the light emitting element in the band of 500 to 700 nm.
  • a sealed body for a bio-applied light irradiation device was formed in the same manner as in Example 1 except that the obtained bio-applied light irradiation device was used. Moreover, the sample for evaluation of Example 3 was produced using the sealing body of the biological application light irradiation device of Example 3 like Example 1. FIG. As a result of evaluating the characteristics of the evaluation sample of Example 3, the evaluation sample of Example 3 had the same tendency as in Example 1.
  • Example 4 A set having a power source and a sealing body for a bio-applied light irradiation device> A set of a sealed body of the biological application light irradiation device of Example 1 and a power source capable of driving the biological application light irradiation device manufactured in Example 1 was prepared. This set was taken as the set of Example 4.
  • the power source 103 and the biological application light irradiation device 101 can be connected via the intermediate connector 102 in the manner shown in FIG.
  • the set of Example 4 was allowed to stand for 2 weeks under conditions of 60 ° C. and 90% relative humidity in an air environment, and then returned to room temperature. Thereafter, the biologically applied light irradiation device (organic EL element) stored in the aluminum protective bag was taken out, and the power source and the biologically applied light irradiation device were connected via a connection cord to obtain a therapeutic sample.
  • the biologically applied light irradiation device which is a therapeutic sample
  • a voltage of 7 V was applied to the light emitting element.
  • the luminance of the biologically applied light irradiation device, which is a therapeutic sample was 5,000 cd / m 2 .
  • the irradiation intensity of the light emitting device of the sample for evaluation was 13 mW / cm 2 . While maintaining this state, the biologically applied light irradiation device, which is a therapeutic sample, could continue to emit light for 3 hours.
  • the present invention can be easily applied to a living body with many curved surfaces, can be used for a disposable device, is inexpensive, and has light irradiation characteristics when stored for a long time in a high temperature and high humidity environment. It turned out that the set containing the sealing body of the biological application light irradiation device which can suppress deterioration of can be provided. Further, such a set is portable, and a user (for example, a patient with skin cancer or the like) can easily carry it at home or out and use it for treatment or beauty.
  • the light emitting part of the bio-applied light irradiation device can be directly applied to the skin, so that the skin can be irradiated with light uniformly, the irradiation intensity is high, and a desired integrated irradiation amount can be obtained in a short time.
  • the burden on the user can also be reduced.
  • the temperature at the time of light emission of the living body applied light irradiation device in this case was 37 ° C.
  • the temperature of the skin of the living body to which the light was irradiated was 37 ° C.
  • FIG. 11 shows the current density-voltage characteristics of the bio-applied light irradiation device produced in the same manner as in Example 1, and FIG. 12 shows the device temperature dependence of the current density.
  • the current density-voltage characteristics in FIG. 11 are as follows: the living body-applied light irradiation device is allowed to stand for at least 1 hour in a thermostat adjusted to 20 ° C., 30 ° C., 40 ° C. or 50 ° C. It was measured by driving at a constant voltage.
  • the device temperature dependence of the current density in FIG. 12 is obtained by plotting the data used in FIG. 11 for each drive voltage with the temperature on the horizontal axis and the current density on the vertical axis. As can be seen from FIG.
  • the current density of this bio-applied light irradiation device shows a clear temperature dependence.
  • the temperature of the bio-applied light irradiation device is 82 mA / cm 2 at 30 ° C. 40 current °C, 100 mA / cm 2 flows but the temperature is 50 ° C. If 115mA / cm 2 of current flows.
  • this living body applied light irradiation device incorporates a circuit having the burn prevention mechanism shown in FIG.
  • the burn prevention mechanism that uses the voltage value and current value set using the temperature dependence of the drive voltage and drive current as an index indirectly senses the temperature of the device and becomes hot. Since the circuit can be cut in some cases, it is extremely effective as a safety measure for medical devices that are in close contact with the skin.
  • this living body-applied light irradiation device can monitor self-heating, and can be used not only as a medical device but also as a temperature sensor in a wide range.
  • the temperature can be detected from the driving voltage or the driving current, there is no need to provide another temperature detecting means such as a thermocouple, and there is an advantage that the device configuration can be simplified.
  • a double-sided pressure-sensitive adhesive tape (Intellimer tape, warm-off type model number WS5130C02) manufactured by Nitta Corporation was applied to the living body application surface at room temperature in the same manner as in Example 1.
  • a bio-applied light irradiation device was produced. When the produced bio-applied light irradiation device was heated to 55 ° C., the adhesive force of the adhesive tape suddenly decreased and the adhesive tape was easily peeled off from the bio-applied surface.
  • a normal pressure-sensitive adhesive tape used in a bio-applied light irradiation device basically does not greatly change the adhesive force depending on the temperature (heat generation) of the bio-applied light irradiation device, but the temperature-sensitive adhesive tape used in this example. Then, when a certain temperature is exceeded, the adhesive force is rapidly reduced, and the living body applicable light irradiation device can be dropped from the living body.
  • a burn prevention mechanism using such a temperature-sensitive adhesive tape can also be highly effective as a safety measure.
  • Example 6 Production and evaluation of a bio-applied light irradiation device having an EL-type luminescent layer
  • the phosphor layer and the metal sealing film were formed on the polyethylene substrate in the pattern shown in FIG.
  • a 30 mm square polyethylene substrate with an anode was attached to a glass support with an adhesive tape to form a composite substrate.
  • the anode is a transparent conductive film (ITO anode) made of indium tin oxide (ITO) having a thickness of 100 nm.
  • a coating type hole injection material (Nissan Chemical Co., Ltd.) was spin-coated on the composite substrate anode to a thickness of 30 nm, and baked at 100 ° C. for 30 minutes in a nitrogen atmosphere to form a hole injection layer.
  • a polyfluorene-based thermally cross-linked interlayer was formed to a thickness of 20 nm and baked at 100 ° C. for 30 minutes in a nitrogen atmosphere.
  • a polymeric red phosphorescent material is spin-coated on this interlayer to a thickness of 50 nm, and baked at 100 ° C. for 30 minutes in a nitrogen atmosphere, thereby emitting a light emitting layer (red phosphorescent light emitting layer: peak wavelength 630 nm).
  • the laminated body composed of the glass support, the polyethylene substrate and the phosphor layer produced in the above process is carried into a glove box in a nitrogen atmosphere, and the organic EL sealing resin is covered so as to cover the phosphor layer.
  • the organic EL sealing resin (Trade name TB3124, manufactured by Three Bond Co., Ltd.) was applied.
  • a metal thin film mainly composed of Al covers the surface of the phosphor layer (upper surface and end surface) on the phosphor-forming surface of the polyethylene substrate, and does not cover a region 1 mm from the periphery of the polyethylene substrate.
  • a metal sealing film was formed.
  • the glass support was peeled from the polyethylene substrate, and an adhesive tape with a release sheet having a width of 5 mm was attached to the peeling side.
  • a bio-applied light irradiation device was produced through the above steps.
  • Example 6 except that the metal sealing film was formed so as to cover the entire surface of the phosphor layer and the entire surface of the polyethylene substrate (the top surface and end surface of the phosphor layer, the light emitter layer non-forming region and end surface of the polyethylene substrate).
  • a bio-applied light irradiation device was produced in the same manner as described above.
  • the bio-applied light irradiation device of Comparative Example 3 was caused to emit light from the light emitter layer, the light derived from the light emission could not be visually recognized from the outside.
  • the living body-applied light irradiation devices produced in Example 6 and each comparative example were emitted with a luminance of 10,000 cd / m 2 , and the temperature at the center of light emission was evaluated with a radiation thermometer (manufactured by Chino).
  • the living body application light irradiation device of Example 6 and Comparative Example 3 had a temperature of 38 ° C.
  • the comparative example 2 was 42 degreeC.
  • the temperature of the light emitting part was evaluated when the voltage became constant after applying a voltage for about 10 minutes. As described above, only the living body application light irradiation device of Example 6 has the light emission that can be confirmed from the outside and the temperature of the surface of the light emitting part remains at a temperature that does not cause low temperature burns.
  • Example 7 a bio-applied light irradiation device similar to that in Example 6 was produced using a polymer blue fluorescent material (peak wavelength: 460 nm) instead of the polymer red phosphorescent material, and the same evaluation was performed. Light was emitted at a luminance of 20,000 cd / m 2 and the temperature at the center was measured and found to be 37 ° C. Also, light emission from the periphery of the substrate was confirmed sufficiently.
  • a polymer blue fluorescent material peak wavelength: 460 nm

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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Abstract

L'invention concerne un corps d'étanchéité pour dispositif d'irradiation de lumière biocompatible, ledit corps d'étanchéité comprenant, à l'intérieur d'un sac de protection doté d'une couche métallique, un dispositif d'irradiation de lumière biocompatible qui comprend un substrat flexible et un élément photoémetteur contenant soit un semi-conducteur organique, soit un point quantique. La présente invention peut être utilisée pour assurer l'étanchéité d'un dispositif jetable pouvant être facilement fixé à un organisme ayant de nombreuses surfaces incurvées. La présente invention permet d'empêcher à moindre coût la détérioration des propriétés d'irradiation de lumière du dispositif même après un stockage de longue durée, dans un environnement à haute température et humidité élevée.
PCT/JP2016/074898 2015-08-28 2016-08-26 Dispositif d'irradiation de lumière biocompatible, procédé d'utilisation d'un dispositif d'irradiation de lumière biocompatible, corps d'étanchéité pour dispositif d'irradiation de lumière biocompatible, procédé de production de corps d'étanchéité pour dispositif d'irradiation de lumière biocompatible, procédé d'utilisation d'un corps d'étanchéité pour dispositif d'irradiation de lumière biocompatible, ensemble, dispositif de traitement de maladies de la peau et dispositif de soins de beauté WO2017038655A1 (fr)

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PL424051A1 (pl) * 2017-12-28 2019-07-01 Liw.Lewant - Fabryka Wyrobów Z Tworzyw Sztucznych Spółka Z Ograniczoną Odpowiedzialnością Urządzenie terapeutyczne do naświetlania jarzeniowego do obniżania stresu i podnoszenia relaksu
WO2020084876A1 (fr) 2018-10-26 2020-04-30 株式会社日本触媒 Feuille électroluminescente à champ électrique organique destinée à être utilisée en photocosmétologie ou en photothérapie
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