WO2017030768A1 - Applicateur de formulation photo-activable - Google Patents

Applicateur de formulation photo-activable Download PDF

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Publication number
WO2017030768A1
WO2017030768A1 PCT/US2016/044695 US2016044695W WO2017030768A1 WO 2017030768 A1 WO2017030768 A1 WO 2017030768A1 US 2016044695 W US2016044695 W US 2016044695W WO 2017030768 A1 WO2017030768 A1 WO 2017030768A1
Authority
WO
WIPO (PCT)
Prior art keywords
photo
formulation
activatable
assembly
electromagnetic energy
Prior art date
Application number
PCT/US2016/044695
Other languages
English (en)
Inventor
Vincenzo CASASANTA, III.
Original Assignee
L'oreal
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by L'oreal filed Critical L'oreal
Publication of WO2017030768A1 publication Critical patent/WO2017030768A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A45—HAND OR TRAVELLING ARTICLES
    • A45D—HAIRDRESSING OR SHAVING EQUIPMENT; EQUIPMENT FOR COSMETICS OR COSMETIC TREATMENTS, e.g. FOR MANICURING OR PEDICURING
    • A45D40/00—Casings or accessories specially adapted for storing or handling solid or pasty toiletry or cosmetic substances, e.g. shaving soaps or lipsticks
    • A45D40/18—Casings combined with other objects
    • A—HUMAN NECESSITIES
    • A45—HAND OR TRAVELLING ARTICLES
    • A45D—HAIRDRESSING OR SHAVING EQUIPMENT; EQUIPMENT FOR COSMETICS OR COSMETIC TREATMENTS, e.g. FOR MANICURING OR PEDICURING
    • A45D33/00—Containers or accessories specially adapted for handling powdery toiletry or cosmetic substances
    • A45D33/26—Containers or accessories specially adapted for handling powdery toiletry or cosmetic substances combined with other objects
    • A45D33/32—Containers or accessories specially adapted for handling powdery toiletry or cosmetic substances combined with other objects with illuminating means
    • A—HUMAN NECESSITIES
    • A45—HAND OR TRAVELLING ARTICLES
    • A45D—HAIRDRESSING OR SHAVING EQUIPMENT; EQUIPMENT FOR COSMETICS OR COSMETIC TREATMENTS, e.g. FOR MANICURING OR PEDICURING
    • A45D34/00—Containers or accessories specially adapted for handling liquid toiletry or cosmetic substances, e.g. perfumes
    • A45D34/04—Appliances specially adapted for applying liquid, e.g. using roller or ball
    • A45D34/041—Appliances specially adapted for applying liquid, e.g. using roller or ball using a roller, a disc or a ball
    • A—HUMAN NECESSITIES
    • A45—HAND OR TRAVELLING ARTICLES
    • A45D—HAIRDRESSING OR SHAVING EQUIPMENT; EQUIPMENT FOR COSMETICS OR COSMETIC TREATMENTS, e.g. FOR MANICURING OR PEDICURING
    • A45D40/00—Casings or accessories specially adapted for storing or handling solid or pasty toiletry or cosmetic substances, e.g. shaving soaps or lipsticks
    • A45D40/26—Appliances specially adapted for applying pasty paint, e.g. using roller, using a ball
    • A45D40/261—Appliances specially adapted for applying pasty paint, e.g. using roller, using a ball using a ball, a roller or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8135—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an acyloxy radical of a saturated carboxylic acid, of carbonic acid or of a haloformic acid; Compositions of derivatives of such polymers, e.g. vinyl esters (polyvinylacetate)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
    • A61Q1/02—Preparations containing skin colorants, e.g. pigments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
    • A61Q1/02—Preparations containing skin colorants, e.g. pigments
    • A61Q1/04—Preparations containing skin colorants, e.g. pigments for lips
    • A61Q1/06—Lipsticks
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q3/00—Manicure or pedicure preparations
    • A61Q3/02—Nail coatings
    • A—HUMAN NECESSITIES
    • A45—HAND OR TRAVELLING ARTICLES
    • A45D—HAIRDRESSING OR SHAVING EQUIPMENT; EQUIPMENT FOR COSMETICS OR COSMETIC TREATMENTS, e.g. FOR MANICURING OR PEDICURING
    • A45D34/00—Containers or accessories specially adapted for handling liquid toiletry or cosmetic substances, e.g. perfumes
    • A45D2034/005—Containers or accessories specially adapted for handling liquid toiletry or cosmetic substances, e.g. perfumes with a cartridge
    • A—HUMAN NECESSITIES
    • A45—HAND OR TRAVELLING ARTICLES
    • A45D—HAIRDRESSING OR SHAVING EQUIPMENT; EQUIPMENT FOR COSMETICS OR COSMETIC TREATMENTS, e.g. FOR MANICURING OR PEDICURING
    • A45D2200/00—Details not otherwise provided for in A45D
    • A45D2200/20—Additional enhancing means
    • A45D2200/205—Radiation, e.g. UV, infrared
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/81—Preparation or application process involves irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/87—Application Devices; Containers; Packaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/87—Application Devices; Containers; Packaging
    • A61K2800/874—Roll-on
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/95—Involves in-situ formation or cross-linking of polymers

Definitions

  • an applicator device includes a photo-active formulation assembly and a photo-dose assembly operably coupled to the photo-active formulation assembly.
  • the photo-active formulation assembly includes a dispenser portion and one or more photo-activatable formulation reservoirs.
  • the photo-active formulation assembly is operable to dispense a photo-activatable formulation from the one or more photo-activatable formulation reservoirs onto one or more regions of a biological surface.
  • the photo-dose assembly includes at least one illuminator oriented to focus electromagnetic energy onto one or more focal regions of a biological surface. The focused electromagnetic energy is of a character and for a duration sufficient to photo-activate the photo-activatable formulation dispensed from the one or more photo-activatable formulation reservoirs.
  • the photo-active formulation assembly includes at least one replaceable formulation cartridge.
  • the photo-active formulation includes one or more photo-active polymers, photo-active oligomers, photo-active monomers, cross-linkable polymers, and the like.
  • the photo-active formulation assembly includes one or more photo-curable materials.
  • the photo-dose assembly includes a light ring proximate the dispenser portion.
  • the photo-dose assembly includes at least one waveguide structure.
  • photo-dose assembly includes one or more waveguides structures configured to direct an emitted electromagnetic energy stimulus to one or more focal regions of a biological surface.
  • waveguide structures include electromagnetic energy waveguides, acoustic energy waveguides (e.g., ultrasonic energy waveguides), optical energy waveguides (e.g., optical fibers, photonic-crystal fibers, or the like), radiation waveguides, thermal energy waveguides, and the like.
  • waveguides structures include diffractive elements (e.g., gratings, cross-gratings, or the like), diffusing elements, etchings, facets, grooves, lens structures, light-diffusing structures, mirrored structures, mirrored surfaces, optical micro-prisms, lenses (e.g., micro-lenses or the like), reflective coatings, reflective materials, reflective surfaces, texturing, thin-films, and the like, and combinations thereof.
  • the waveguide structure comprises structures suitable for directing electromagnetic energy waves.
  • the waveguide structure comprises at least one of a transparent, translucent, or light-transmitting material, and combinations or composites thereof.
  • transparent, translucent, or light-transmitting materials include those materials that offer a low optical attenuation rate to the transmission or propagation of light waves.
  • transparent, translucent, or light-transmitting materials include borosilicate glasses, crystals, epoxies, glasses, optically clear materials, plastics, polymers, resins, semi-clear materials, thermal resins, thermo plastics, and the like, and combinations or composites thereof.
  • the photo-dose assembly 26 includes a plurality of waveguide structures.
  • the photo-active formulation assembly includes a roller assembly for dispensing the photo-activatable formulation onto the one or more regions of the biological surface and the photo-dose assembly includes a light ring proximate the roller assembly.
  • the photo-dose assembly includes one or more waveguides.
  • the roller assembly comprises one or more waveguides.
  • the photo-dose assembly is configured to modify a spectral parameter based on information indicative of a photo-curing composition type.
  • the photo-dose assembly includes circuitry configured to modify one more parameters associated with emission intensity, emission phase, emission polarization, emission wavelength (e.g., a peak emission wavelength, a radiation wavelength, an average emission wavelength, or the like), pulse frequency, and the like responsive to one or more inputs indicative of a photo-curing composition type.
  • the spectral parameter includes one or more of a wavelength of the focused electromagnetic energy, an intensity of the focused electromagnetic energy, or a duration of the focused electromagnetic energy.
  • the photo-active formulation assembly dispenses the photo-activatable formulation from the one or more photo-activatable formulation reservoirs onto the one or more regions of a biological surface at rate commensurate with a photo-curing rate.
  • the at least one illuminator is arranged concentric about the dispenser portion of the photo-active formulation assembly.
  • the electromagnetic energy is selected based on the photo-activatable formulation in the one or more photo-activatable formulation reservoirs.
  • the focused electromagnetic energy comprises electromagnetic energy at a plurality of wavelengths, and wherein the plurality of wavelengths are operable to photo-activate a plurality of coatings of photo-activatable formulations.
  • the photo-active formulation assembly includes at least one photo-activatable formulation nebulizer.
  • a method of applying a photo-activatable formulation includes dispensing, by a dispenser portion of a photo-active formulation assembly, photo-activatable formulation from one or more photo-activatable formulation reservoirs onto one or more regions of a biological surface and focusing, by a photo-dose assembly operably coupled to the photo-active formulation assembly, electromagnetic energy from at least one illuminator onto one or more focal regions of the biological surface.
  • the focused electromagnetic energy is of a character and for a duration sufficient to photo-activate the photo-activatable formulation dispensed from the one or more photo-activatable formulation reservoirs.
  • the photo-active formulation assembly is a part of a replaceable formulation cartridge, and wherein dispensing the photo-activatable formulation includes dispensing the photo-activatable formulation from the replaceable formulation cartridge.
  • the method further includes removing the replaceable formulation cartridge from an applicator that includes the photo-dose assembly, coupling a second replaceable formulation cartridge to the applicator, and dispensing, from the second replaceable formulation cartridge, a second photo-activatable formulation onto the one or more regions of the biological surface.
  • the method further includes focusing, by the photo-dose assembly, electromagnetic energy from the at least one illuminator onto the one or more focal regions of the biological surface, the focused electromagnetic energy of a character and for a duration sufficient to photo-activate the second photo-activatable formulation dispensed from the second replaceable formulation cartridge.
  • FIGURE 1 depicts a perspective view of an embodiment of an applicator for dispensing photo-activatable formulations and photo-activating the dispensed photo-activatable formulations, in accordance with embodiments described herein;
  • FIGURE 2 depicts another perspective view of the embodiment of the applicator depicted in FIGURE 1, in accordance with embodiments described herein;
  • FIGURE 3 depicts a side cross-sectional view of the embodiment of the applicator depicted in FIGURE 1, in accordance with embodiments described herein;
  • FIGURES 4 and 5 depict side and perspective exploded views, respectively, of the embodiment of the applicator depicted in FIGURE 1, in accordance with embodiments described herein;
  • FIGURE 6 depicts a partial cross-sectional view of an embodiment of a dispenser end of the applicator depicted in FIGURE 1, in accordance with embodiments described herein;
  • FIGURE 7 depicts an end view of an embodiment of a dispenser end of the embodiment of the applicator depicted in FIGURE 1, in accordance with embodiments described herein;
  • FIGURE 8 depicts a perspective view of the embodiment of the applicator depicted in FIGURE 1, in accordance with embodiments described herein;
  • FIGURE 9 depicts an embodiment of a method of applying a photo-activatable formulation, which can be performed using embodiments of applicators capable of dispensing and photo-activating photo-activatable formulations described herein.
  • Formulation applicators are used to apply formulations to skin and other biological surfaces.
  • the ability to apply a formulation from an applicator can be especially convenient for users.
  • Other formulation containers, such as jars, bottles, and the like, lead to waste amounts of formulation in the containers and reduced usable life of formulation from exposure to air and other environmental factors.
  • Formulations applied to skin include makeup, personal soaps, skin care products, hair care products or other any other cosmetic products.
  • Some formulations have been developed to be activated by light or other electromagnetic energy. These formulations, sometimes called photo-activatable formulations, are photo-activatable in some manner by exposure to electromagnetic energy of a particular character and for a particular duration.
  • activation of the photo-activatable formulations includes material changes of the photo- activatable formulations, reactions of the photo-activatable formulations, or any other type of action or change by the photo-activatable formulations.
  • material changes of the photo-activatable formulations include changes in viscosity responsive to an electromagnetic energy stimulus.
  • a material change or reaction includes cross-linking, controlled release, or radical generation.
  • the electromagnetic energy activates the photo-activatable formulations, causing the change or action.
  • the activation wavelength is a specific wavelength or a range of wavelengths.
  • the photo-active formulation includes at least one of photo-active polymers, photo-active oligomers, photo-active monomers, cross-linkable polymers, or photo-curable materials.
  • photo-activatable formulations include cross-linked polymers and oligomers for foundation, lipstick, nail polish, dermal covers, dermal fillers, and other cosmetic formulations.
  • cross-linked polymers and oligomers include photo-radical initiated polyethylene glycol acrylates and photo-crosslinkable stilbazole (SbQ) functionalized backbones (SMA-SbQ, PVA-SbQ).
  • SbQ photo-crosslinkable stilbazole
  • PVA-SbQ materials are efficiently crosslinked using ultraviolet electromagnetic energy at a wavelength of 365 nm.
  • Other formulations are being developed that are designed to crosslink at longer wavelengths into the visible portion of the spectrum (i.e., with wavelengths greater than 400 nm).
  • FIGURES 1 to 8 Depicted in FIGURES 1 to 8 are embodiments of an applicator 20 for dispensing photo-activatable formulations and activating the dispensed photo-activatable formulations.
  • FIGURES 1 and 2 depict perspective views of embodiments of the applicator 20.
  • FIGURE 3 depicts a side cross-sectional view of embodiments of the applicator 20.
  • FIGURES 4 and 5 depict side and perspective exploded views, respectively, of embodiments of the applicator 20.
  • FIGURE 6 depicts a partial cross-sectional view of an embodiment of a dispenser end of the applicator 20.
  • FIGURE 7 depicts an end view of an embodiment of a dispenser end of the applicator 20.
  • FIGURE 8 depicts a perspective view of an embodiment of the applicator 20.
  • the applicator 20 includes a photo-active formulation assembly 22.
  • the photo-active formulation assembly 22 includes a dispenser portion 24 operable to dispense a photo-activatable formulation onto one or more regions of a biological surface (e.g., a portion of skin).
  • the dispenser portion 24 is a ball dispenser.
  • the ball of the ball dispenser is a metal ball, a ceramic ball, or a polymer ball.
  • the dispenser portion 24 comprises a dispenser having a regular or irregular cross-sectional geometry.
  • the dispenser portion 24 comprises a dispenser having a spheroid geometric shape, a cylindrical shape, and the like.
  • the dispenser portion 24 comprises a textured surface. In some embodiments, the dispenser portion 24 comprises a surface having at least one hydrophobic coating, hydrophilic coating, and the like. In some embodiments, the dispenser portion 24 comprises a surface material having a coefficients of friction ranging from about 0.15 to about 0.3. In some embodiments, the dispenser portion 24 comprises a surface material having a coefficients of friction ranging from about 0.005 to 0.2.
  • the applicator 20 includes one or more photo-activatable formulation reservoirs from which the photo-activatable formulation is dispensed onto one or more regions of a biological surface.
  • the applicator 20 also includes a photo-dose assembly 26 operably coupled to the photo-active formulation assembly 22.
  • the photo-dose assembly 26 includes at least one illuminator oriented to focus electromagnetic energy onto one or more focal regions of a biological surface.
  • the focused electromagnetic energy from the photo-dose assembly 26 is of a character and for a duration sufficient to photo-activate the photo-activatable formulation dispensed from the photo-active formulation assembly 22.
  • the photo-dose assembly 26 includes a light ring 28 located substantially concentric with the photo-active formulation assembly 22.
  • the light ring 28 is also located such that electromagnetic energy emitted from at least one illuminator of the photo-dose assembly 26 passes through the light ring 28 and is directed toward one or more focal regions of a biological surface.
  • a spectral parameter type e.g., a wavelength, an intensity, or a duration
  • the light ring 28 is configured to focus the electromagnetic energy emitted by the at least one illuminator and includes one or more of a lens, a diffuser, or a grating.
  • the applicator 20 also includes a housing 30.
  • the housing 30 holds the photo-active formulation assembly 22 and the photo-dose assembly 26 such that at least one illuminator of the photo-dose assembly 26 is oriented to focus electromagnetic energy onto one or more focal regions of a biological surface with the focused electromagnetic energy of a character and for a duration sufficient to photo-activate the photo-activatable formulation dispensed from one or more photo-activatable formulation reservoirs of the photo-active formulation assembly 22.
  • the applicator 20 also includes features, such as an activator such as a button 32 or grips 34, to aid in use of the applicator 20 by a user.
  • the button 32 is power button on an end opposite the photo-active formulation assembly 22 and configured to toggle power to the photo-dose assembly 26.
  • the housing 30 also includes grips 34 that add to the convenience for a user to grip the applicator 20.
  • the photo-dose assembly 26 of the applicator 20 includes at least one illuminator 36.
  • illuminators 36 include arc flashlamps, cavity resonators, continuous wave bulbs, electric circuits, electrical conductors, electromagnetic energy emitting emitters, electromagnetic radiation emitters, electro-mechanical components, electro-opto components, incandescent emitters, laser diodes, lasers, light-emitting diodes (e.g., organic light-emitting diodes, polymer light-emitting diodes, polymer phosphorescent light-emitting diodes, microcavity light-emitting diodes, high-efficiency light-emitting diodes, and the like), quantum dots, and the like.
  • organic light-emitting diodes e.g., organic light-emitting diodes, polymer light-emitting diodes, polymer phosphorescent light-emitting diodes, microcavity light-emitting diodes, high-efficiency light-emitting
  • the at least one illuminator 36 is a source of electromagnetic energy, such as a light emitting diode (LED).
  • the at least one illuminator 36 includes six LEDs; however, the at least one illuminator 36 may include any number of illuminators, such as a single illuminator or a plurality of illuminators.
  • the at least one illuminator 36 is arranged to focus electromagnetic energy onto one or more focal regions of a biological surface of a character and for a duration sufficient to photo-activate the photo-activatable formulation dispensed from one or more photo-activatable formulation reservoirs of the photo-active formulation assembly 22.
  • the at least one illuminator 36 includes a patterned illuminator having a plurality of spaced-apart electromagnetic energy emitting elements.
  • one or more spectral parameters of the electromagnetic energy emitted by the at least one illuminator 36 are selected based on a particular photo-activatable formulation.
  • the at least one illuminator 36 includes at least one LED that includes III-V semiconductor materials or III-N semiconductor materials.
  • wavelengths are available from the ultraviolet range (i.e., from about 10 nm to about 400 nm), through the visible range (i.e., from about 400 nm to about 700 nm), and into the infrared range (from about 700 nm to about 1 mm) of the electromagnetic spectrum.
  • the power density and dimensions of these devices also cover a wide range.
  • a plurality of illuminators are configured to emit radiation having one or more peak emission wavelengths in the infrared, visible, or ultraviolet spectrum, or combinations thereof.
  • at least illuminator 36 comprises a peak emission wavelength ranging from about 700 nanometers to about 1 millimeter.
  • at least one illuminator 36 comprises a peak emission wavelength ranging from about 5 micrometers to about 10 micrometers.
  • at least on illuminator 36 comprises a peak emission wavelength ranging from about 400 nanometers to about 700 nanometers.
  • a the photo-dose assembly 26 includes circuitry configured to vary one or more of emission intensity, emission phase, emission polarization, emission wavelength (e.g., a peak emission wavelength, a radiation wavelength, an average emission wavelength, or the like), pulse frequency, and the like.
  • the photo-dose assembly 26 also includes at least one waveguide structure 38.
  • the at least one illuminator 36 is arranged to emit electromagnetic energy toward the at least one waveguide structure 38.
  • the at least one waveguide structure 38 is configured to transmit the electromagnetic energy from the at least one illuminator 36.
  • the at least one waveguide structure 38 includes six electromagnetic energy pipes.
  • the at least one waveguide structure 38 is formed from segmented glass, polymer, or any other material that can transmit electromagnetic energy.
  • the number of at least one waveguide structure 38 is equal to a number of the at least one illuminator 36; however, differing numbers of the at least one illuminator 36 and the at least one waveguide structure 38 are possible.
  • the numbers of the at least one illuminator 36 and the at least one waveguide structure 38 are selected based on based on a size of the applicator 20, light flux requirements of photo-activatable formulations, or any other factor.
  • the source of electromagnetic energy also includes the light ring 28.
  • the at least one waveguide structure 38 are configured to transmit the electromagnetic energy from the at least one illuminator 36 to the light ring 28.
  • One or both of the at least one waveguide structure 38 or the light ring 28 is configured to focus the electromagnetic energy and the photo-dose assembly 26 is oriented to direct the focused electromagnetic energy to one or more focal regions of a biological surface to photo-activate photo-activatable formulation dispensed from the one or more photo-activatable formulation reservoirs.
  • the applicator 20 also includes a controller 40, such as control circuitry, for the at least one illuminator 36.
  • the controller 40 controls power to the at least one illuminator 36.
  • the controller 40 modifies a spectral parameter of the electromagnetic energy emitted from the at least one illuminator 36 (e.g., wavelength, intensity, duration, and the like) based on information indicative of a photo-curing composition type, photo-curing protocol, and the like.
  • the controller 40 modifies a parameter associated with an illumination temporal pattern, an illumination spaced-apart pattern, and the like based on information indicative of a photo-curing protocol.
  • the controller 40 modifies a spectral parameter of the electromagnetic energy emitted from the at least one illuminator 36 such that the emitted electromagnetic energy is configured to photo-activate the dispensed photo-activatable formulation on the one or more regions of a biological surface.
  • the applicator 20 also includes a power source 42, such as a rechargeable battery.
  • the applicator 20 includes one or more power sources 42.
  • power sources include one or more button cells, chemical battery cells, a fuel cell, secondary cells, lithium ion cells, micro-electric patches, nickel metal hydride cells, silver-zinc cells, capacitors, super-capacitors, thin film secondary cells, ultra-capacitors, zinc-air cells, or the like.
  • power sources include one or more generators (e.g., electrical generators, thermo energy-to-electrical energy generators, mechanical-energy-to-electrical energy generators, micro-generators, nano-generators, or the like) such as, for example, thermoelectric generators, piezoelectric generators, electromechanical generators, or the like.
  • the power source includes at least one rechargeable power source.
  • the power source includes one or more micro-batteries, printed micro-batteries, thin film batteries, fuel cells (e.g., biofuel cells, chemical fuel cells etc.), and the like
  • the power source 42 is configured to provide power to the at least one illuminator 36.
  • the applicator includes a power controller 44.
  • the power controller 44 includes one or more of a charging coil, a charging circuit, or an actuator for the power button 32.
  • the charging coil permits the power source 42 to be recharged inductively.
  • the applicator 20 is recharged when placed in a cradle configured to inductively recharge the power source 42 of the applicator 20.
  • the applicator 20 also includes one or more photo-activatable formulation reservoirs 46 that hold photo-activatable formulation 48.
  • the photo-active formulation assembly 22 is arranged to dispense the photo-activatable formulation 48 to a one or more regions of a biological surface.
  • the photo-active formulation assembly 22 is a roller assembly for dispensing the photo-activatable formulation onto the one or more regions of a biological surface. As the roller assembly is rolled over one or more regions of a biological surface, an amount of the photo-activatable formulation 48 is dispensed to the one or more regions of a biological surface.
  • the roller assembly is a waveguide that guides electromagnetic energy from the photo-dose assembly 26.
  • photo-active formulation assembly 22 dispenses the photo-activatable formulation 48 from the one or more photo-activatable formulation reservoirs 46 onto one or more regions of a biological surface at rate commensurate with a photo-curing rate of the photo-activatable formulation 48.
  • the photo-active formulation assembly 22 includes at least one photo-activatable formulation nebulizer.
  • the photo-activatable formulation nebulizer delivers the photo-activatable formulation 48 in the form of a mist when the photo-active formulation assembly 22 dispenses the photo-activatable formulation 48.
  • the one or more photo-activatable formulation reservoirs 46 are configured to limit exposure of the photo-activatable formulation 48 to electromagnetic energy prior to the photo-activatable formulation 48 being dispensed to the one or more regions of a biological surface. Limiting exposure of the photo-activatable formulation 48 to electromagnetic energy prior to being dispensed reduces the possibility that the photo-activatable formulation 48 will be activated before it is dispensed.
  • the one or more photo-activatable formulation reservoirs 46 are formed integrally with the applicator 20. In another embodiment, as discussed below, the one or more photo-activatable formulation reservoirs 46 are removable from the applicator 20.
  • the photo-active formulation assembly 22 including the one or more photo-activatable formulation reservoirs 46 and the photo-activatable formulation 48, are contained within a replaceable formulation cartridge 50.
  • the replaceable formulation cartridge 50 is removably couplable to the applicator 20.
  • the photo-active formulation assembly 22 is also removably couplable to the photo-dose assembly 26.
  • the replaceable formulation cartridge 50 includes external threads that engage internal threads of a structural member 52 of the applicator 20.
  • the replaceable formulation cartridge 50 is removably couplable to the applicator 20 by other mechanisms, such as a snap connector, a magnetic coupling, or any other releasable coupling mechanism.
  • This interchangeability of formulation cartridges allows a user to couple the replaceable formulation cartridge 50 to the source of electromagnetic energy, dispense the photo-activatable formulation 48 from the replaceable formulation cartridge 50 to a one or more regions of a biological surface, and focus electromagnetic energy onto one or more focal regions of a biological surface (e.g., by the at least one illuminator 36) to activate the photo-activatable formulation 48 dispensed on the one or more regions of the biological surface.
  • the replaceable formulation cartridge 50 can then be removed from the applicator 20 and then a different formulation cartridge can be coupled to the applicator 20.
  • This interchangeability of formulation cartridges allows different photo-active assemblies to be used with the photo-dosing assembly 26.
  • a user is able to dispense different photo-activatable formulations from different formulation cartridges and activate the different photo-activatable formulations using the same photo-dosing assembly 26 of the applicator 20. It also allows the formulation cartridges to be disposable items while the other portions of the applicator 20 are used over a longer period of time.
  • focused electromagnetic energy from the photo-dose assembly 26 comprises electromagnetic energy at multiple wavelengths where the multiple wavelengths are operable to photo-activate multiple coatings of photo-activatable formulations.
  • the at least one illuminator 36 is located at an end of the replaceable formulation cartridge 50 opposite the dispenser portion 24. This positioning places the at least one illuminator 36 away from the area where the replaceable formulation cartridge 50 is inserted into and coupled to the applicator 20 so that the at least one illuminator 36 is not damaged or misaligned by the coupling or decoupling of the replaceable formulation cartridge 50. This positioning also places the at least one illuminator 36 closer to the power source 42.
  • the at least one illuminator 36 is located at an end of the replaceable formulation cartridge 50 opposite the photo-active formulation assembly 22, the at least one waveguide structure 34 and the light ring 28 are arranged to transmit the electromagnetic energy from the at least one illuminator 36 and emit the focused electromagnetic energy toward the one or more regions of a biological surface where the photo-activatable formulation 48 has been dispensed.
  • the replaceable formulation cartridge 50 includes an identifier.
  • the identifier identifies one or more of the replaceable formulation cartridge 50, the photo-activatable formulation 48 inside the replaceable formulation cartridge 50, an activation wavelength of the photo-activatable formulation 48 inside the replaceable formulation cartridge 50, an activation power of the photo-activatable formulation 48 inside the replaceable formulation cartridge 50, or any other information about the photo-activatable formulation 48 or the replaceable formulation cartridge 50.
  • the identifier has the form of one or more of a radio-frequency identification (RFID) tag, a color on the replaceable formulation cartridge 50, a barcode on the replaceable formulation cartridge 50, printed information on the replaceable formulation cartridge 50, or any other kind of identifier.
  • RFID radio-frequency identification
  • one or more spectral parameters of the source of electromagnetic energy are variable.
  • the at least one illuminator 36 includes a plurality of illuminators having different wavelengths that can be powered separately.
  • the at least one illuminator 36 is capable of being powered at different levels of power.
  • the controller 40 controls the one or more spectral parameters of the at least one illuminator 36.
  • the characteristics of the source of electromagnetic energy are variable and the replaceable formulation cartridge 50 includes an identifier, one or more spectral parameters of the source of electromagnetic energy are modified based on the identifier of the replaceable formulation cartridge 50.
  • the identifier may indicate that the photo-activatable formulation 48 has an activation wavelength of 365 nm and the source of electromagnetic energy is adjusted to emit electromagnetic energy at about 365 nm when the replaceable formulation cartridge 50 is coupled to the applicator 20.
  • the dispenser portion 24 of the photo-active formulation assembly 22 is shown as being located substantially concentrically with the light ring 28.
  • the electromagnetic energy emitted from the light ring 28 surrounds the area of the photo-active formulation assembly 22. This increases the likelihood that any photo-activatable formulation dispensed by the photo-active formulation assembly 22 will be exposed to focused electromagnetic energy emitted from the light ring 28.
  • the proximity of the light ring 28 to the photo-active formulation assembly 22 also decreases the time between the dispensing of the photo-activatable formulation by the photo-active formulation assembly 22 and the exposure of the dispensed photo-activatable formulation to the focused electromagnetic energy emitted by the light ring 28.
  • the benefits of the embodiments of the applicator 20 described herein include that the photo-activatable formulation is dispensed from and activated by a single, self-contained unit.
  • Conventional formulation applicators dispense formulations but do not include sources of electromagnetic energy.
  • a conventional formulation applicator was used to dispense a photo-activatable formulation, a separate light device would be required to expose the photo-activatable formulation to the appropriate electromagnetic energy.
  • the two-step process of applying the photo-activatable formulation with an applicator and activating the photo-activatable formulation with a separate light source is cumbersome for the user and risks improper application and/or activation of the photo-activatable formulation.
  • the embodiments of the applicator 20 described herein limit exposure of the photo-activatable formulation to electromagnetic energy before the photo-activatable formulation is dispensed, reduce the time period between applying the photo-activatable formulation to the one or more regions of a biological surface and activating the photo-activatable formulation using electromagnetic energy, and emit activating electromagnetic energy in close proximity to the location where the photo-activatable formulation is dispensed.
  • FIGURE 9 depicts an embodiment of a method 60 of applying a photo-activatable formulation, which can be performed using embodiments of applicators capable of dispensing and photo-activating photo-activatable formulations described herein.
  • photo-activatable formulation is dispensed by a dispenser portion of a photo-active formulation assembly from one or more photo-activatable formulation reservoirs onto one or more regions of a biological surface.
  • electromagnetic energy is focused by a photo-dose assembly operably coupled to the photo-active formulation assembly from at least one illuminator onto one or more focal regions of the biological surface.
  • the focused electromagnetic energy is of a character and for a duration sufficient to photo-activate the photo-activatable formulation dispensed from the one or more photo-activatable formulation reservoirs.
  • the method 60 includes the steps depicted in blocks 62 and 64.
  • the method 60 includes generating an electromagnetic energy stimulus responsive to one or more inputs indicative of a photo-curing composition type.
  • the applicator 20 is operable to detect information about a formulation within a reservoir, cartridge, and the like, and to adjust one or more photo-curing parameters (e.g., a wavelength of the electromagnetic energy, an intensity of the electromagnetic energy, a duration of the electromagnetic energy, and the like) based on the detected information.
  • the method 60 includes varying in real time one or more photo-curing parameters (e.g., a peak emission wavelength of the electromagnetic energy, an intensity of the electromagnetic energy, a duration of the electromagnetic energy, and the like) based on a detected measurement indicative of a curing rate.
  • one or more photo-curing parameters e.g., a peak emission wavelength of the electromagnetic energy, an intensity of the electromagnetic energy, a duration of the electromagnetic energy, and the like
  • the method 60 includes varying one or more photo-curing parameters (e.g., a peak emission wavelength of the electromagnetic energy, an intensity of the electromagnetic energy, a duration of the electromagnetic energy, and the like) based on a detected measurement indicative of a photo-activatable formulation dispensing rate.
  • one or more photo-curing parameters e.g., a peak emission wavelength of the electromagnetic energy, an intensity of the electromagnetic energy, a duration of the electromagnetic energy, and the like.
  • the method 60 includes varying one or more photo-curing parameters (e.g., a peak emission wavelength of the electromagnetic energy, an intensity of the electromagnetic energy, a duration of the electromagnetic energy, and the like) based on a detected measurement indicative of which cartridge is dispensing photo-activatable formulation.
  • photo-curing parameters e.g., a peak emission wavelength of the electromagnetic energy, an intensity of the electromagnetic energy, a duration of the electromagnetic energy, and the like
  • the method 60 includes generating the focused electromagnetic energy responsive to one or more inputs indicative of a photo-curing protocol associated with a formulation within a reservoir, cartridge, and the like.
  • the method 60 optionally includes the steps depicted in blocks 66, 68, and 70.
  • the replaceable formulation cartridge is removed from an applicator that includes the photo-dose assembly.
  • a second replaceable formulation cartridge is coupled to the applicator.
  • a second photo-activatable formulation is dispensed from the second replaceable formulation cartridge onto the one or more regions of the biological surface.
  • the steps depicted in blocks 66, 68, and 70 permit the applicator that includes the photo-dose assembly to be used with multiple replaceable formulation cartridges. In one example, this ability permits a user to dispense and photo-activate multiple photo-activatable formulations using the same applicator.
  • the applicator is configured to modify one or more spectral parameters of the electromagnetic energy from the photo-dose assembly based on the different replaceable formulation cartridges coupled to the applicator and/or the different photo-activatable formulations dispensed from the replaceable formulation cartridges.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Dermatology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pathology (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Radiation-Therapy Devices (AREA)

Abstract

La présente invention concerne un dispositif applicateur (20) comprenant un ensemble formulation photo-active (22) et un ensemble photo-dose (26) couplé de manière opérationnelle à l'ensemble formulation photo-active (22). L'ensemble formulation photo-active (22) comprend une partie distributeur (24) et un ou plusieurs réservoirs de formulation photo-activable. L'ensemble formulation photo-active (22) peut servir à distribuer une formulation photo-activable à partir du ou des réservoirs de formulation photo-activable sur une ou plusieurs régions d'une surface biologique. L'ensemble photo-dose (26) comprend au moins un illuminateur (36) orienté pour concentrer l'énergie électromagnétique sur une ou plusieurs régions focales d'une surface biologique. L'énergie électromagnétique focalisée présente un caractère et une durée suffisants pour photo-activer la formulation photo-activable distribuée à partir du ou des réservoirs de formulation photo-activable.
PCT/US2016/044695 2015-08-18 2016-07-29 Applicateur de formulation photo-activable WO2017030768A1 (fr)

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US14/829,370 2015-08-18
US14/829,370 US10034530B2 (en) 2015-08-18 2015-08-18 Photo-activatable formulation applicator

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US10034530B2 (en) 2018-07-31
US10842241B2 (en) 2020-11-24

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