WO2017025074A1 - Dispositif de mesure électromécanique et de surveillance d'activités physiologiques dans un tissu musculaire stapédien stimulé électriquement (capteur de ekehrt) - Google Patents

Dispositif de mesure électromécanique et de surveillance d'activités physiologiques dans un tissu musculaire stapédien stimulé électriquement (capteur de ekehrt) Download PDF

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Publication number
WO2017025074A1
WO2017025074A1 PCT/DE2016/000290 DE2016000290W WO2017025074A1 WO 2017025074 A1 WO2017025074 A1 WO 2017025074A1 DE 2016000290 W DE2016000290 W DE 2016000290W WO 2017025074 A1 WO2017025074 A1 WO 2017025074A1
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WO
WIPO (PCT)
Prior art keywords
sensor element
measuring device
sensor
biocompatible
electrode
Prior art date
Application number
PCT/DE2016/000290
Other languages
German (de)
English (en)
Inventor
Karsten Ehrt
Rüdiger Dahl
Attila OVARI
Robert Arndt MLYNSKI
Original Assignee
Universität Rostock
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universität Rostock filed Critical Universität Rostock
Priority to DE112016003629.9T priority Critical patent/DE112016003629A5/de
Publication of WO2017025074A1 publication Critical patent/WO2017025074A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6813—Specially adapted to be attached to a specific body part
    • A61B5/6814—Head
    • A61B5/6815—Ear
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/12—Audiometering
    • A61B5/121—Audiometering evaluating hearing capacity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
    • A61B5/686—Permanently implanted devices, e.g. pacemakers, other stimulators, biochips
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6867—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive specially adapted to be attached or implanted in a specific body part
    • A61B5/6878—Bone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0526—Head electrodes
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04R—LOUDSPEAKERS, MICROPHONES, GRAMOPHONE PICK-UPS OR LIKE ACOUSTIC ELECTROMECHANICAL TRANSDUCERS; DEAF-AID SETS; PUBLIC ADDRESS SYSTEMS
    • H04R25/00—Deaf-aid sets, i.e. electro-acoustic or electro-mechanical hearing aids; Electric tinnitus maskers providing an auditory perception
    • H04R25/30—Monitoring or testing of hearing aids, e.g. functioning, settings, battery power
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04R—LOUDSPEAKERS, MICROPHONES, GRAMOPHONE PICK-UPS OR LIKE ACOUSTIC ELECTROMECHANICAL TRANSDUCERS; DEAF-AID SETS; PUBLIC ADDRESS SYSTEMS
    • H04R25/00—Deaf-aid sets, i.e. electro-acoustic or electro-mechanical hearing aids; Electric tinnitus maskers providing an auditory perception
    • H04R25/60—Mounting or interconnection of hearing aid parts, e.g. inside tips, housings or to ossicles
    • H04R25/604—Mounting or interconnection of hearing aid parts, e.g. inside tips, housings or to ossicles of acoustic or vibrational transducers
    • H04R25/606—Mounting or interconnection of hearing aid parts, e.g. inside tips, housings or to ossicles of acoustic or vibrational transducers acting directly on the eardrum, the ossicles or the skull, e.g. mastoid, tooth, maxillary or mandibular bone, or mechanically stimulating the cochlea, e.g. at the oval window
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6879—Means for maintaining contact with the body
    • A61B5/6882—Anchoring means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/18—Internal ear or nose parts, e.g. ear-drums
    • A61F2002/183—Ear parts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0526—Head electrodes
    • A61N1/0541—Cochlear electrodes
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04R—LOUDSPEAKERS, MICROPHONES, GRAMOPHONE PICK-UPS OR LIKE ACOUSTIC ELECTROMECHANICAL TRANSDUCERS; DEAF-AID SETS; PUBLIC ADDRESS SYSTEMS
    • H04R25/00—Deaf-aid sets, i.e. electro-acoustic or electro-mechanical hearing aids; Electric tinnitus maskers providing an auditory perception
    • H04R25/70—Adaptation of deaf aid to hearing loss, e.g. initial electronic fitting

Definitions

  • Measuring device for the mechanoelectric measurement and monitoring of physiological activities in an electrically evoked stapedius muscle tissue eKEHRT sensor
  • the invention relates to a measuring device for measurement and monitoring
  • eKEHRT sensor electrically evoked Stapediusmuskelgewebe
  • the human ear can be subdivided into the outer ear, middle ear and inner ear.
  • the middle ear includes eardrum, the eustachian tube, the tympanic cavity with the
  • Ossicular chain ligaments and middle ear muscles.
  • the ossicles Ossicular chain consists of hammer, anvil and stirrup.
  • the eardrum is set in vibration by incoming sound waves through the outer ear.
  • both muscles contract reflexively, so that the mechanical coupling of the eardrum to the inner ear (and thus the power transmission) is reduced. As a result, a protection of the inner ear against excessive sound pressure is possible.
  • the tension of the stapedius muscle which is triggered by high sound pressure, is also called a stapedius reflex. From the diagnosis of the stapedius reflex it is possible to obtain medically relevant information about the functionality of the ear. Furthermore, the measurement of the Stapediusreflexes for setting or calibration is so
  • cochlear implants useful because of the measured Stapediusreflex on the sonic energy perceived by a patient can be closed. It is known to use for measuring the Stapediusreflexes electrodes which are brought into contact with the stapedius muscle and the action currents or action potentials generated in a contraction of the stapedius muscle to a
  • the stapedius muscle is disposed within a cavity present in a bone and only the connected to the stirrup tendon of the stapedius muscle and the upper part of the interior of the middle ear are accessible.
  • An existing measuring system for ESRT measurement (Electrically Evoked Stapedius Reflex Threshold) consisting of a first electrode and a
  • Fixing element is described in WO 2008 148 822 A1, wherein the first electrode is connected to a first elongated electrical line and wherein the first electrode of an elongated base body (with a first end) and a second end, wherein the first electrical line with the
  • Base body is connected in the region of the second end and wherein means are provided for reversibly fixing the fixing element to the first electrode.
  • This electrode arrangement is used to measure the action current and / or the action potential of an electrically active tissue, preferably the
  • the fixation of the first electrode in the stapedius muscle tissue is carried out by a separately introduced fixation element, wherein the fixing element penetrates the base body of the first electrode, preferably the lateral surface and thus, for example, on the tendon of the
  • the invention according to DE 60 032 490 T2 describes a system for adapting the function of a cochlear implant, wherein the cochlear implant for
  • the system includes
  • Processing means coupled to the cochlear implant and adapted to analyze the electrical voltage signals, provide an optimum value for an excitation signal in response to at least one selected parameter determined, which is derived from the electrical voltage signals. There is a bipolar measurement of the action potential of the tissue.
  • the electrode has an elongated electrode body having a first end and a second end.
  • the electrode is shaped such that it can be passed through a tissue only in a forward direction along the longitudinal axis of the electrode body.
  • the electrode is shaped such that it can be passed through a tissue only in a forward direction along the longitudinal axis of the electrode body.
  • Electrode base body Means for permanent or temporary mechanical blocking of the movement of the electrode through a tissue in one
  • Electrode can be easily removed by further in
  • the electrode body is flexible and has at least one passive or active fixing element.
  • at least three passive or active fixing elements are arranged circumferentially on the electrode base body and the fixing elements are arranged at the same angle in a plane perpendicular to the longitudinal axis (evenly distributed) from each other.
  • the at least one fixing element is formed by a hook or by a spring.
  • the invention according to DE 69 728 173 T2 relates to an implantable cochlear stimulator (ICS) with an implantable self-adaptive circuit for adapting such ICS to a specific patient, wherein "adapting" to the process of determining and setting the amplitude or intensity of the stimuli generated by the ICS to a level or adaptation that both effectively, ie, allows the ICS to perform its intended function optimally, and is comfortable and thus not excessively loud or painful to the patient.
  • a method for self-adapting an ICS to a specific one To determine patients using objective feedback rather than subjective feedback to determine the pacing parameters for the patient.
  • US Pat. No. 6,208,882 (B1) describes a stapedial reflex electrode and plug for detecting a patient's stapled reflexes, and an implantable connector used to electrically connect the stapledius reflex electrode to an implantable cochlear stimulator (ICS) or other implantable device.
  • ICS implantable cochlear stimulator
  • Stapedius muscle or at a nearby location where the stapedius muscle is visible and where it leaves a bony canal in the middle ear.
  • Electrode is designed as a biocompatible metal wire with a flat blade and provided with a sharp tip and serrations along one edge.
  • An insulated wire is electrically and mechanically attached to the blade. Such attachment may be made by welding and wrapping the insulated lead at one end of the wire around the body of the electrode and protecting such weld and wrap fasteners with covers with a coating of epoxy resin.
  • the electrode blade is inserted through a small slit in the muscle tissue. Alternatively, the electrode next to the muscle tissue through an opening in the
  • Bone wall are inserted, which passes through the bone canal, wherein the electrode protrudes with a tip from the bone canal. The projecting tip is then bent over to rest and fix against the bone wall.
  • Other embodiments of a stirrup electrode are also shown, with the distal end of a multi-core insulated wire in the
  • Stapedius muscle tissue is embedded with a needle.
  • a fitting is used to electrically connect a lead to the form of the implanted electrode in conjunction with a stapes implant device.
  • the tube connector is a platinum tube that is welded at one end to a lead from the implant device. A proximal end of the lead of the electrode is crimped at the other end of the tube. A silicone tube or sleeve is then placed over the tube and sealed at both ends.
  • the current practice is to observe the stapedial muscle activity during or after electrical stimulation under the surgical microscope and manually to register. After the end of the operation, no observation or monitoring is possible.
  • the invention according to US 201 10255 731 A1 describes a transducer and external magnetic fields, in particular a transducer which can be used to monitor the stirrup of a human ear Implants are often electromagnetic transducers which serve as an actuator, a sensor and / or a switch
  • the transducer includes a housing and at least one coil coupled to the housing, a magnet being within the housing
  • the biasing elements are used at a resonant frequency, thus reducing the friction between the magnet and the inner surface of the housing, which may cause interference.
  • Electrical signals through the at least one coil cause the magnet to oscillate with respect to the housing along an axis.
  • the vibration of the magnet causes inertial vibration of the housing, thus generating vibrations in the inner ear. Implants can too
  • Electromagnetic sensors include using electromagnetic sensors that can be used without restriction in converting the mechanical vibrations of an ossicle in the middle ear into an electrical signal. Another application of an electromagnetic sensor can detect the stapedius reflex. Medically relevant
  • Information about the functionality of the ear can be obtained from the diagnosis of the stapedius reflex detection. Furthermore, the measurement of
  • Stapediusreflexe used for setting and / or calibration of so-called cochlear implants, since the sound energy can be perceived by a patient from the measured Stapediusreflexen.
  • a previously filed patent application DE 10 2014 009 387.5 describes a sensor arrangement for registering electrical activities in the target tissue, consisting of a Hall sensor and a permanent magnet.
  • Measuring device is used for non-contact mechanoelectric measurement and monitoring of physiological activities in an electrically evoked
  • Stapedius muscle tissue for setting and calibrating cochlear implants
  • the measuring device being made of a biocompatible
  • the sensor element which is arranged on or on or around a movable structure in the cavity of the middle ear with a corresponding fastener and is connected via a deflection electrode with the cochlear implant, not shown.
  • the sensor element is designed as a biocompatible measuring electrode or as a biocompatible Hall sensor, wherein the round magnet used in the cochlear implant for fixing the external speech processor and / or integrated on or at the discharge electrode or arranged in a bone window in the middle ear cavity Miniature magnet for generating a
  • the mechanoelectric transducers described in the prior art are based on the fixation of a coil. It is not apparent from the illustrations how the necessary relative movement of the magnetic core with respect to the coil winding is achieved. The transmission of the movement of the ossicular chain on a movable magnetic core within a coil only leads to one
  • the object of the invention is to determine the physiological activity of an electrically evoked tissue (stapedius muscle) by a non-contact detection or measurement, thereby avoiding the disadvantages of the prior art.
  • the object is achieved by a measuring device for non-contact mechanoelectrical measurement and monitoring of physiological activities in an electrically evoked staped lymph muscle tissue (eKEHRT sensor) for setting and calibrating cochlear implants, wherein the measuring device consists of a biocompatible sensor element (1) connected to or on or around a mobile structure in the middle ear cavity with a corresponding one
  • eKEHRT sensor electrically evoked staped lymph muscle tissue
  • Fastener (4) is arranged and connected via a discharge electrode (5) with a cochlear implant, not shown.
  • the round magnet (6) used in the cochlear implant for attaching the external speech processor is used to generate a magnetic field, wherein an additional sensor attached to or in the lead-off electrode (5) or mounted in a bone window in the middle ear cavity, the sensitivity of the sensor element (1 ) and an adjustment of the sensor element (1) facilitating miniature coil (7) is arranged.
  • the sensor element (1) as a
  • biocompatible measuring electrode (2) or be designed as a biocompatible Hall sensor (3).
  • the sensor element (1) and miniature coil (7) is formed in a further embodiment of the invention as a biocompatible measuring electrode (2), wherein the
  • Sensor element (1) on the ossicular chain (long anvil limb, Stapek ankle) may be arranged.
  • the arrangement of the sensor element (1) and miniature coil (7) can also be reversed, in which case the sensor element (1) in the bone window and the miniature coil (7) can be fastened to the ossicular chain.
  • the sensor element (1) can be implemented in one-dimensional (1 D) or two-dimensional (2D) or three-dimensional (3D).
  • FIG. 1 is a schematic representation of a schematic of a typical vehicle.
  • the electrically evocable tissue (stapedius muscle) is connected to the ossicular chain via a tendon.
  • the sensor element (1) in the form of a biocompatible Hall sensor (3) is arranged on or on a movable structure in the cavity of the middle ear, in particular on the ossicular chain (long anvil limb, stapes bones) with a corresponding fastening element (4) and allows accurate measurement of physiological activity.
  • Sensor element (1) can be designed one-dimensional (1 D) or two-dimensional (2D) or three-dimensional (3D).
  • the sensor element (1) is attached to the ossicle chain with a clinically proven titanium tab as a fastening element (4) and connected to an additional lead electrode (5) to the existing intracochlear electrode support with a cochlear implant, not shown.
  • the multi-dimensionality of the sensor element (1) facilitates the adjustment in tight spaces in the middle ear. In the currently established design of the
  • Cochlear implants is a round magnet (6) for attaching the external
  • Speech processor already part of the system and is used to generate a magnetic field.
  • Ableitelektrode (5) integrated or mounted in a bone window in the middle ear cavity increases the sensitivity of the Hall sensor (3) crucial and allows easier adjustment of the sensor element (1). Changes in the position of the ossicle chain or of the sensor element (1) are detected as an alternating signal.
  • the leakage voltage (5) of the Hall voltage for the mechanoelectric measurement of the stapedius reflex (ESRT) is additionally arranged on the cochlear implant and can be used as active feedback for the control of the speech processor.
  • the inventive solution also includes a modification of
  • the miniature coil (7) will be on or around or around the moving ossicular chain and the Hall sensor (3) will be located in an additional bone window attached. The detection of the physiological activity of electrically evoked
  • Tissue which is located in the middle ear of humans, is done by a non-contact measurement. It is an indirect measure of stapedial muscle activity. Compared to the prior art, the
  • Measuring device with respect to the object to be measured Stapedius muscle atraumatic attached and is suitable for long-term monitoring. It can be used as a physiological feedback signal for the objective control of a cochlear implant.
  • the Hall sensor (3) operates without contact, is very sensitive to changes in the magnetic field and allows a better detection of the movement of the ossicular chain than with electrical or optical conduction.
  • Characteristic curve is almost linear in the near field range.
  • the small dimensions allow optimal positioning in the cavum of the middle ear.
  • Measuring device can be in a correspondingly robust and wear-free
  • the Hall element (3) on the long anvil limb and the miniature coil would be fixed firmly in the cavity of the middle ear.
  • Intraoperative ESRT measurement to confirm correct insertion of the implantable electrode carrier for the intracochlear electrodes could be objectified by using automatic test procedures. This would reduce the necessary duration of surgery. In case of uncooperative patients and children possible overstimulation can be avoided.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Otolaryngology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Surgery (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medical Informatics (AREA)
  • Acoustics & Sound (AREA)
  • Neurosurgery (AREA)
  • Signal Processing (AREA)
  • Audiology, Speech & Language Pathology (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Multimedia (AREA)
  • Prostheses (AREA)

Abstract

L'invention concerne un dispositif de mesure et de surveillance d'activités physiologiques dans un tissu musculaire stapédien stimulé électriquement (capteur de EKEHRT), en particulier pour mesurer sans contact l'activité physiologique du tissu stimulé électriquement, qui est située dans l'oreille moyenne de l'être humain. Le dispositif de mesure comprend un élément de détection biocompatible (1). L'élément de détection biocompatible (1) est disposé au niveau ou près ou autour d'une structure mobile dans la cavité de l'oreille moyenne avec un élément de fixation correspondant (4) et est relié par une électrode de dérivation (5) à l'implant cochléaire non représenté et l'aimant circulaire (6), inséré dans l'implant cochléaire pour fixer le processeur vocal externe, est utilisé pour générer un champ magnétique. Une mini-bobine (7) supplémentaire, augmentant la sensibilité de l'élément de détection (1) et facilitant l'ajustement de l'élément de détection (1), est intégrée à ou dans l'électrode de dérivation (5) ou montée dans une fenêtre osseuse ménagée dans la cavité de l'oreille moyenne.
PCT/DE2016/000290 2015-08-08 2016-07-26 Dispositif de mesure électromécanique et de surveillance d'activités physiologiques dans un tissu musculaire stapédien stimulé électriquement (capteur de ekehrt) WO2017025074A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE112016003629.9T DE112016003629A5 (de) 2015-08-08 2016-07-26 Messvorrichtung zur mechanoelektrischen Messung und Monitoring physiologischer Aktivitäten in einem elektrisch evozierten Stapediusmuskelgewebe (eKEHRT-Sensor)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102015010272.9 2015-08-08
DE102015010272.9A DE102015010272A1 (de) 2015-08-08 2015-08-08 Messvorrichtung zur mechanoelektrischen Messung und Monitoring physiologischer Aktivitäten in einem elektrisch evozierten Stapediusmuskelgewebe (eKEHRT-Sensor)

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WO2017025074A1 true WO2017025074A1 (fr) 2017-02-16

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Country Status (2)

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DE (2) DE102015010272A1 (fr)
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022087297A1 (fr) * 2020-10-23 2022-04-28 Massachusetts Institute Of Technology Avancées magnétomicrométriques dans une commande robotique
US11992307B2 (en) 2017-10-10 2024-05-28 Massachusetts Institute Of Technology Method for neuromechanical and neuroelectromagnetic mitigation of limb pathology

Citations (9)

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Publication number Priority date Publication date Assignee Title
US6208882B1 (en) 1998-06-03 2001-03-27 Advanced Bionics Corporation Stapedius reflex electrode and connector
DE69728173T2 (de) 1996-06-20 2005-02-03 Advanced Bionics Corp., Sylmar Selbsteinstellendes cochleares implantatsystem
DE60032490T2 (de) 1999-03-03 2007-09-27 Cochlear Ltd., Lane Cove Gerät zur optimierung der funktion eines kochlearen implantates
DE102007026057A1 (de) 2007-06-01 2008-12-11 Universität Rostock Elektrode und Messvorrichtung zur Messung der elektrischen Aktivität in einem elektrisch aktiven Gewebe
WO2008148822A1 (fr) 2007-06-05 2008-12-11 Med-El Elektromedizinische Geräte G.M.B.H. Ensemble d'électrodes et dispositif de mesure destiné à mesurer l'activité électrique dans un tissu électriquement actif
US20100145177A1 (en) * 2007-02-19 2010-06-10 Med-El Elektromedizinische Geraete Gmbh Stapedius Muscle Electrode
US20110137180A1 (en) * 2009-12-04 2011-06-09 Advanced Bionics AG, c/o Froriep Renggli Systems and Methods for Fitting a Cochlear Implant System to a Patient Based on Stapedius Displacement
US20110255731A1 (en) 2002-04-01 2011-10-20 Med-El Elektromedizinische Geraete Gmbh Transducer for Stapedius Monitoring
DE102014009387A1 (de) 2014-06-25 2015-12-31 Universität Rostock Messvorrichtung zur mechanoelektrischen Messung und Monitoring physiologischer Aktivitäten in einem elektrisch evozierten Stapediusmuskelgewebe (KEHRT-Sensor)

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69728173T2 (de) 1996-06-20 2005-02-03 Advanced Bionics Corp., Sylmar Selbsteinstellendes cochleares implantatsystem
US6208882B1 (en) 1998-06-03 2001-03-27 Advanced Bionics Corporation Stapedius reflex electrode and connector
DE60032490T2 (de) 1999-03-03 2007-09-27 Cochlear Ltd., Lane Cove Gerät zur optimierung der funktion eines kochlearen implantates
US20110255731A1 (en) 2002-04-01 2011-10-20 Med-El Elektromedizinische Geraete Gmbh Transducer for Stapedius Monitoring
US20100145177A1 (en) * 2007-02-19 2010-06-10 Med-El Elektromedizinische Geraete Gmbh Stapedius Muscle Electrode
DE102007026057A1 (de) 2007-06-01 2008-12-11 Universität Rostock Elektrode und Messvorrichtung zur Messung der elektrischen Aktivität in einem elektrisch aktiven Gewebe
WO2008148822A1 (fr) 2007-06-05 2008-12-11 Med-El Elektromedizinische Geräte G.M.B.H. Ensemble d'électrodes et dispositif de mesure destiné à mesurer l'activité électrique dans un tissu électriquement actif
US20110137180A1 (en) * 2009-12-04 2011-06-09 Advanced Bionics AG, c/o Froriep Renggli Systems and Methods for Fitting a Cochlear Implant System to a Patient Based on Stapedius Displacement
DE102014009387A1 (de) 2014-06-25 2015-12-31 Universität Rostock Messvorrichtung zur mechanoelektrischen Messung und Monitoring physiologischer Aktivitäten in einem elektrisch evozierten Stapediusmuskelgewebe (KEHRT-Sensor)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11992307B2 (en) 2017-10-10 2024-05-28 Massachusetts Institute Of Technology Method for neuromechanical and neuroelectromagnetic mitigation of limb pathology
WO2022087297A1 (fr) * 2020-10-23 2022-04-28 Massachusetts Institute Of Technology Avancées magnétomicrométriques dans une commande robotique

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