WO2017016159A1 - 用于去斑活血的中药组合物及其制备方法 - Google Patents

用于去斑活血的中药组合物及其制备方法 Download PDF

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WO2017016159A1
WO2017016159A1 PCT/CN2015/098606 CN2015098606W WO2017016159A1 WO 2017016159 A1 WO2017016159 A1 WO 2017016159A1 CN 2015098606 W CN2015098606 W CN 2015098606W WO 2017016159 A1 WO2017016159 A1 WO 2017016159A1
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parts
servings
chinese medicine
traditional chinese
medicine composition
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PCT/CN2015/098606
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English (en)
French (fr)
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张贯京
陈兴明
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深圳市前海颐老科技有限公司
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Publication of WO2017016159A1 publication Critical patent/WO2017016159A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/89—Cyperaceae (Sedge family)
    • A61K36/8905—Cyperus (flatsedge)

Definitions

  • the invention relates to the technical field of medicine, in particular to a traditional Chinese medicine composition for removing speckle and promoting blood circulation and a preparation method thereof.
  • Chloasma is commonly known as butterfly spot, and it is also called “face syndrome" in Chinese medicine.
  • the mechanism of Chinese medicine is caused by sinful skin, qi and blood, liver qi stagnation, and qi stagnation and blood stasis.
  • the cause of western medicine of chloasma is caused by female endocrine disorders, mental stress and other factors.
  • the combination of prevention and treatment is mainly used for the chloasma of the skin.
  • Regulating women's endocrine environment, maintaining a comfortable mood, and preventing gynecological diseases are effective means to prevent chloasma, and now there is such a misunderstanding in the treatment of chloasma: spotting is simply to stay on the surface of the skin, with some exfoliation Cosmetics, etc., even some patients are more eager to remove the spots, choose the fast-acting stripping method to remove spots, seriously damage the user's own skin surface.
  • a large number of decoction capsules have also appeared on the market, but the curative effect is difficult to maintain, forming a status quo that requires long-term treatment.
  • the object of the present invention is to provide a traditional Chinese medicine composition for removing spotted blood circulation and a preparation method thereof, which has mild action and long-lasting effect, and can obviously improve the symptoms of chloasma; for young women who have just started plaque, despeckle can be achieved. effect.
  • the present invention provides a traditional Chinese medicine composition for de-population and blood circulation, which comprises the following parts by weight:
  • Lithosperm 3 ⁇ 8 servings, Salvia: 1 ⁇ 5 servings, white peony: 1 ⁇ 5 servings, silkworm: 1 ⁇ 4 servings, red peony: 1 ⁇ 4 servings, hematoxylin: 1 ⁇ 5 servings, safflower: 1 ⁇ 5 copies, Chuanpu: 1 ⁇ 5 parts, loofah: 1 ⁇ 5 parts, fragrant: 1 ⁇ 5 parts, psyllium: 1 ⁇ 3 parts, tortoise shell: 1 ⁇ 7 parts.
  • the traditional Chinese medicine composition consists of the following parts by weight:
  • Lithosperm 3 ⁇ 6 parts, Salvia: 1 ⁇ 3 parts, white peony: 1 ⁇ 3 parts, silkworm: 1 ⁇ 3 parts, red peony: 1 ⁇ 3 parts, hematoxylin: 1-3 parts, safflower: 1 ⁇ 3 servings, Chuanpu: 1 ⁇ 3 servings, loofah: 1 ⁇ 3 servings, fragrant: 1 ⁇ 3 servings, psyllium: 1 ⁇ 3 servings, tortoise shell: 1 ⁇ 5 servings.
  • the traditional Chinese medicine composition consists of the following parts by weight:
  • Lithosperm 4 ⁇ 6 parts, Salvia: 2 ⁇ 3 parts, white peony: 2 ⁇ 3 parts, silkworm: 2 ⁇ 3 parts, red peony: 2 ⁇ 3 parts, hematoxylin: 2 ⁇ 3 parts, safflower: 2 ⁇ 3 servings, Chuanpu: 2 ⁇ 3 servings, loofah: 2 ⁇ 3 servings, fragrant: 2 ⁇ 3 servings, psyllium: 2 ⁇ 3 servings, tortoise shell: 2 ⁇ 5 servings.
  • the traditional Chinese medicine composition consists of the following parts by weight:
  • Lithosperm 6 parts, Salvia: 2 parts, white peony: 2 parts, silkworm: 3 parts, red peony: 3 parts, hematoxylin: 2 parts, safflower: 2 parts, Chuanpu: 3 parts, loofah: 3 Parts, fragrant: 2 servings, psyllium: 2 servings, tortoise shell: 2 servings.
  • the traditional Chinese medicine composition consists of the following parts by weight:
  • Lithosperm 6 parts, Salvia: 3 parts, white peony: 3 parts, silkworm: 2 parts, red peony: 2 parts, hematoxylin: 3 parts, safflower: 3 parts, Chuanpu: 2 parts, loofah: 2 Parts, fragrant: 3, psyllium: 3, tortoise shell: 2 copies.
  • the traditional Chinese medicine composition consists of the following parts by weight:
  • Lithospermum 4 parts, Salvia: 2 parts, white peony: 2 parts, silkworm: 3 parts, red peony: 3 parts, hematoxylin: 2 parts, safflower: 2 parts, Chuanpu: 3 parts, loofah: 3 Parts, fragrant: 2 servings, psyllium: 2 servings, tortoise shell: 2 servings.
  • the traditional Chinese medicine composition consists of the following parts by weight:
  • Lithospermum 4 parts, Salvia: 3 parts, white peony: 3 parts, silkworm: 2 parts, red peony: 2 parts, hematoxylin: 3 parts, safflower: 3 parts, Chuanpu: 2 parts, loofah: 2 Parts, fragrant: 3, psyllium: 3, tortoise shell: 2 copies.
  • the traditional Chinese medicine composition consists of the following parts by weight:
  • Lithospermum 5 parts, Salvia: 3 parts, white peony: 3 parts, silkworm: 2 parts, red peony: 2 parts, hematoxylin: 3 parts, safflower: 3 parts, Chuanpu: 2 parts, loofah: 2 Parts, fragrant: 3, psyllium: 3, tortoise shell: 3 copies.
  • the traditional Chinese medicine composition consists of the following parts by weight:
  • Lithospermum 5 parts, Salvia: 3 parts, white peony: 2 parts, silkworm: 2 parts, red peony: 3 parts, hematoxylin: 2 parts, safflower: 2 parts, Chuanpu: 3 parts, loofah: 3 Parts, fragrant: 2 servings, psyllium: 2 servings, tortoise shell: 2 servings.
  • the traditional Chinese medicine composition consists of the following parts by weight:
  • Lithospermum 5 parts, Salvia: 3 parts, white peony: 3 parts, silkworm: 2 parts, red peony: 2 parts, hematoxylin: 3 parts, safflower: 3 parts, Chuanpu: 3 parts, loofah: 2 Parts, fragrant: 3, psyllium: 2, tortoise shell: 2 copies.
  • the traditional Chinese medicine composition consists of the following parts by weight:
  • Lithospermum 5 parts, Salvia: 2 parts, white peony: 2 parts, silkworm: 3 parts, red peony: 3 parts, hematoxylin: 2 parts, safflower: 2 parts, Chuanpu: 3 parts, loofah: 3 Parts, fragrant: 2 servings, psyllium: 3, tortoise shell: 3 servings.
  • the traditional Chinese medicine composition consists of the following parts by weight:
  • Lithospermum 5 parts, Salvia: 3 parts, white peony: 2 parts, silkworm: 2 parts, red peony: 3 parts, hematoxylin: 2 parts, safflower: 3 parts, Chuanpu: 3 parts, loofah: 3 Parts, fragrant: 2 parts, psyllium: 2 parts, tortoise shell: 3 parts.
  • the traditional Chinese medicine composition consists of the following parts by weight:
  • Lithospermum 5 parts, Salvia: 2 parts, white peony: 3 parts, silkworm: 3 parts, red peony: 3 parts, hematoxylin: 3 parts, safflower: 2 parts, Chuanpu: 3 parts, loofah: 3 Parts, fragrant: 2 parts, psyllium: 2 parts, tortoise shell: 3 parts.
  • the present invention also provides a preparation method of a traditional Chinese medicine composition for de spotting and activating blood, and the preparation method comprises the following steps:
  • each batch of 20g is mixed for the first time.
  • the time for the first powdering is 30 s ⁇ 35 s, forming a mixture AA;
  • the mixture AA is re-pulverized, the time of re-pulping is 90 s ⁇ 95 s, forming a mixture BB;
  • the present invention provides a preparation method of a traditional Chinese medicine composition for de spotting and activating blood, and the preparation method may further comprise the following steps:
  • each batch of 20g is mixed for the first time.
  • the time for the first powdering is 45 s ⁇ 50 s, forming a mixture AA';
  • the mixture AA' is re-pulverized, the time of re-pulping is 75 s ⁇ 80 s, forming a mixture BB';
  • the invention adopts comfrey, salvia miltiorrhiza, white peony, silkworm, red peony, hematoxylin, safflower, chuanpu, loofah, xiangfu, psyllium and tortoise as pharmaceutical components, and synergistically acts to harmonize blood and blood.
  • the effect of soothing liver and relieving stagnation, promoting blood circulation and removing phlegm and removing radiance can significantly improve the symptoms of chloasma and improve the quality of life of patients; for young women who have just started plaque, the effect of removing plaque can be achieved; for pregnancy spots, Age spots, chloasma, etc. can achieve the effect of desalination.
  • the invention provides a traditional Chinese medicine composition for de-population and blood circulation, wherein the traditional Chinese medicine composition is composed of the following parts by weight:
  • Lithosperm 3 ⁇ 8 servings, Salvia: 1 ⁇ 5 servings, white peony: 1 ⁇ 5 servings, silkworm: 1 ⁇ 4 servings, red peony: 1 ⁇ 4 servings, hematoxylin: 1 ⁇ 5 servings, safflower: 1 ⁇ 5 copies, Chuanpu: 1 ⁇ 5 parts, loofah: 1 ⁇ 5 parts, fragrant: 1 ⁇ 5 parts, psyllium: 1 ⁇ 3 parts, tortoise shell: 1 ⁇ 7 parts.
  • Lithospermum Sexually cold, sweet and salty; has the effect of cooling blood, promoting blood circulation and detoxifying and diarrhea; it is used for blood heat poisoning, macaque purple, sore, eczema and other symptoms.
  • the comfrey has significant anti-acne and anti-inflammatory effects and has great cosmetic value.
  • the main function of comfrey is cooling blood, promoting blood circulation and removing blood stasis, detoxification and rash, thus accelerating the metabolism of acne marks, scars and scars, thus on the face.
  • the skin plays a good bactericidal and anti-inflammatory effect.
  • Salvia bitterness, slightly cold; heart, heart, liver; Danshen has the effect of nourishing blood and calming the nerves and removing spots and promoting blood circulation; used for irritability, poor mental health and palpitations.
  • the cause of dull skin and even pigmentation in women's face is related to lung heat, liver stagnation, yin deficiency and other reasons, and it is inseparable from qi stagnation and blood stasis.
  • Salvia miltiorrhiza can nourish blood and nourish blood, sputum and stasis, regulate tissue repair and regeneration, improve facial microcirculation, make blood flow smooth, and glory on the face, so that facial capillaries have been replenished.
  • White peony also known as fragrant white sputum; taste Xin, warm, lung, spleen, stomach, large intestine; with blood circulation and pus and analgesic effect; white peony powder "Compendium of Materia Medica” said white ⁇ "long skin, moist color, can be used as noodles Lipid" for pruritus, hemorrhoids and other symptoms.
  • White peony has a significant effect on whitening and spotting, and can improve microcirculation, promote skin metabolism, and delay skin aging.
  • Silkworm medicinal salty, spicy, flat; mainly used for skin itching, sore throat, facial nerve palsy and other diseases; ancient medical books have recorded that "white silkworm can eliminate dark spots, it is good to look good", is an ancient female beauty A traditional Chinese medicine that is commonly used when removing spots.
  • white silkworm contains amino acids, vitamin E and active leucine, which can regulate the secretion of sex hormones, scavenge free radicals, and cause pigmentation such as chloasma caused by endocrine disorders and anti-lipid oxidation. They all have good anti-spotting effect, and it can also accelerate cell metabolism, improve skin microcirculation, remove dull skin, sunburn and increase skin elasticity.
  • Red peony It has the effects of clearing heat and cooling blood, dispersing phlegm and relieving pain, purging fire and removing spots. It is mainly used for skin long spots and scabs; red sputum due to stagnation, cold, main liver, function to clear blood stasis And the effect of cooling blood to stop bleeding, dilated and eliminate spots.
  • red peony, safflower and loofah It is often compatible with red peony, safflower and loofah, and has good curative effect on liver spots, toxic black skin disease and secondary pigmentation of the face.
  • Safflower Sexual temperature, spicy, with the effect of beauty de-spotting, promoting blood circulation; promoting blood circulation, accelerating blood circulation, promoting new rewards, increasing melanin produced by melanocytes, and promoting retention in the body
  • the melanin is decomposed so that it does not precipitate to form a stain, or the pigment of the lake is decomposed and excreted.
  • Chuanpu Sexual temperature and sin; it has the effect of eliminating gas, eliminating dampness and removing mud; Chuanpu often cooperates with hematoxylin, red peony, safflower and loofah to play against liver spots, black skin disease and facial A good therapeutic effect of secondary pigmentation.
  • Loofah also known as phlegm medicine, Tongluo medicine, heat-clearing medicine, cooling blood to stop bleeding; has the effect of clearing the vitality, detoxification and swelling; the saponin in loofah, loofah bitterness, mucus, wood glue, melon Special substances such as amino acid, xylan and interferon have certain special effects.
  • the loofah contains vitamin b1 to prevent skin aging, whitening vitamin C and other ingredients, which can protect the skin, eliminate plaque, and make the skin white. tender.
  • Xiangfu It has the effect of relieving qi, relieving depression and regulating pain and relieving pain; it is used for liver qi stagnation, irregular menstruation, menstrual dysmenorrhea and breast pain. From the point of view of Chinese medicine beauty, qi medicine can disperse qi stagnation, smooth liver qi, qi qi down, and regulate viscera, so it has a conditioning effect on facial melasma, acne, edema and other harmful diseases. Therefore, Xiangfu cooperates with other ingredients in this side to achieve the effect of whitening and de-spotting and delaying aging.
  • Psyllium chinensis Slightly cold, sweet, light; has the effect of clearing heat and diuresis, soaking and diarrhea and eyesight; mainly used for edema fullness, summer dampness and diarrhea.
  • Tortoiseshell slightly cold, salty, sweet; return to the liver, kidney, heart; has the effect of nourishing yin and yang, strengthening kidney and strengthening bone and nourishing the heart; tortoise shell contains protein (about 32%), collagen (collagen), etc.
  • the composition contains various amino acids such as aspartic acid, threonine, methionine, phenylalanine, and leucine.
  • Tortoiseshell is an important nourishing yin drug.
  • Plasma cAMP accounts for a comparative advantage in yin deficiency, and cGMP in yang deficiency. Take a comparative advantage. Tortoiseshell and red peony, white silkworm, and white peony can effectively remove facial spots and brown-blue spots around the eyelids.
  • the comfrey has the effects of cooling blood, promoting blood circulation and detoxifying and diarrhea; in addition, comfrey has significant anti-acne and anti-inflammatory effects, can accelerate the metabolism of acne marks, scars and scars, thereby Facial skin plays a good bactericidal and anti-inflammatory effect; Danshen can promote blood circulation and nourish blood, sputum and stasis, regulate tissue repair and regeneration, improve facial microcirculation; white peony has the effect of promoting blood circulation and relieving pain, and can improve microcirculation and promote Skin metabolism, delaying skin aging; silkworm is mainly used for skin itching, sore throat, facial nerve paralysis and other diseases; red peony has the effect of clearing heat and cooling blood, dispersing phlegm and relieving pain and purging fire to remove spots, mainly used for long skin spots, Asthma embolism, red peony often with rehmannia, peony bark, salvia, safflower and other cool
  • tortoise shell has yin and yang The effect of strengthening kidney and strengthening bones and nourishing blood; tortoise shell is an important nourishing yin medicine, tortoise shell and red peony, white silkworm, white peony simmered in water, through their synergistic effect to effectively treat facial spots and brown cyan around the eyelids spot.
  • the effects of qi and blood harmonization, liver dispelling stagnation, promoting blood circulation and removing phlegm and removing radiance can be improved, the symptoms of chloasma can be obviously improved, and the quality of life of patients can be improved; Women can achieve the effect of removing spots; for pregnancy spots, age spots, chloasma, etc. can achieve the effect of desalination.
  • the components of the traditional Chinese medicine composition for de-population and blood circulation are as follows:
  • Lithospermum 3 ⁇ 7 servings, Salvia: 1 ⁇ 4 servings, white peony: 1 ⁇ 3 servings, silkworm: 1 ⁇ 4 servings, red peony: 1 ⁇ 4 servings, hematoxylin: 1 ⁇ 5 servings, safflower: 1 ⁇ 5 copies, Chuanpu: 1 ⁇ 5 parts, loofah: 1 ⁇ 5 parts, fragrant: 1 ⁇ 5 parts, psyllium: 1 ⁇ 3 parts, tortoise shell: 1 ⁇ 7 parts.
  • the traditional Chinese medicine composition consists of the following parts by weight:
  • Lithosperm 3 ⁇ 6 parts, Salvia: 1 ⁇ 3 parts, white peony: 1 ⁇ 3 parts, silkworm: 1 ⁇ 3 parts, red peony: 1 ⁇ 3 parts, hematoxylin: 1-3 parts, safflower: 1 ⁇ 3 servings, Chuanpu: 1 ⁇ 3 servings, loofah: 1 ⁇ 3 servings, fragrant: 1 ⁇ 3 servings, psyllium: 1 ⁇ 3 servings, tortoise shell: 1 ⁇ 5 servings.
  • the traditional Chinese medicine composition consists of the following parts by weight:
  • Lithosperm 4 ⁇ 6 parts, Salvia: 2 ⁇ 3 parts, white peony: 2 ⁇ 3 parts, silkworm: 2 ⁇ 3 parts, red peony: 2 ⁇ 3 parts, hematoxylin: 2 ⁇ 3 parts, safflower: 2 ⁇ 3 servings, Chuanpu: 2 ⁇ 3 servings, loofah: 2 ⁇ 3 servings, fragrant: 2 ⁇ 3 servings, psyllium: 2 ⁇ 3 servings, tortoise shell: 2 ⁇ 5 servings.
  • the traditional Chinese medicine composition consists of the following parts by weight:
  • Lithosperm 6 parts, Salvia: 2 parts, white peony: 2 parts, silkworm: 3 parts, red peony: 3 parts, hematoxylin: 2 parts, safflower: 2 parts, Chuanpu: 3 parts, loofah: 3 Parts, fragrant: 2 servings, psyllium: 2 servings, tortoise shell: 2 servings.
  • the traditional Chinese medicine composition consists of the following parts by weight:
  • Lithosperm 6 parts, Salvia: 3 parts, white peony: 3 parts, silkworm: 2 parts, red peony: 2 parts, hematoxylin: 3 parts, safflower: 3 parts, Chuanpu: 2 parts, loofah: 2 Parts, fragrant: 3, psyllium: 3, tortoise shell: 2 copies.
  • the traditional Chinese medicine composition consists of the following parts by weight:
  • Lithospermum 4 parts, Salvia: 2 parts, white peony: 2 parts, silkworm: 3 parts, red peony: 3 parts, hematoxylin: 2 parts, safflower: 2 parts, Chuanpu: 3 parts, loofah: 3 Parts, fragrant: 2 servings, psyllium: 2 servings, tortoise shell: 2 servings.
  • the traditional Chinese medicine composition consists of the following parts by weight:
  • Lithospermum 4 parts, Salvia: 3 parts, white peony: 3 parts, silkworm: 2 parts, red peony: 2 parts, hematoxylin: 3 parts, safflower: 3 parts, Chuanpu: 2 parts, loofah: 2 Parts, fragrant: 3, psyllium: 3, tortoise shell: 2 copies.
  • the traditional Chinese medicine composition consists of the following parts by weight:
  • Lithospermum 5 parts, Salvia: 3 parts, white peony: 3 parts, silkworm: 2 parts, red peony: 2 parts, hematoxylin: 3 parts, safflower: 3 parts, Chuanpu: 2 parts, loofah: 2 Parts, fragrant: 3, psyllium: 3, tortoise shell: 3 copies.
  • the components of the traditional Chinese medicine composition for de-population and blood circulation are as follows:
  • Lithospermum 5 parts, Salvia: 2 parts, white peony: 2 parts, silkworm: 3 parts, red peony: 3 parts, hematoxylin: 2 parts, safflower: 2 parts, Chuanpu: 3 parts, loofah: 3 Parts, fragrant: 2 servings, psyllium: 2 servings, tortoise shell: 2 servings.
  • the components of the traditional Chinese medicine composition for de-population and blood circulation are as follows:
  • Lithospermum 5 parts, Salvia: 3 parts, white peony: 3 parts, silkworm: 2 parts, red peony: 2 parts, hematoxylin: 3 parts, safflower: 3 parts, Chuanpu: 2 parts, loofah: 2 Parts, fragrant: 3, psyllium: 3, tortoise shell: 2 copies.
  • the components of the traditional Chinese medicine composition for de-population and blood circulation are as follows:
  • Lithospermum 5 parts, Salvia: 3 parts, white peony: 2 parts, silkworm: 2 parts, red peony: 3 parts, hematoxylin: 2 parts, safflower: 2 parts, Chuanpu: 3 parts, loofah: 3 Parts, fragrant: 2 servings, psyllium: 2 servings, tortoise shell: 2 servings.
  • the components of the traditional Chinese medicine composition for de-population and blood circulation are as follows:
  • Lithospermum 5 parts, Salvia: 3 parts, white peony: 3 parts, silkworm: 2 parts, red peony: 2 parts, hematoxylin: 3 parts, safflower: 3 parts, Chuanpu: 3 parts, loofah: 2 Parts, fragrant: 3, psyllium: 2, tortoise shell: 2 copies.
  • the components of the traditional Chinese medicine composition for de-population and blood circulation are as follows:
  • Lithospermum 5 parts, Salvia: 2 parts, white peony: 2 parts, silkworm: 3 parts, red peony: 3 parts, hematoxylin: 2 parts, safflower: 2 parts, Chuanpu: 3 parts, loofah: 3 Parts, fragrant: 2 servings, psyllium: 3, tortoise shell: 3 servings.
  • the components of the traditional Chinese medicine composition for de-population and blood circulation are as follows:
  • Lithospermum 5 parts, Salvia: 3 parts, white peony: 2 parts, silkworm: 2 parts, red peony: 3 parts, hematoxylin: 2 parts, safflower: 3 parts, Chuanpu: 3 parts, loofah: 3 Parts, fragrant: 2 parts, psyllium: 2 parts, tortoise shell: 3 parts.
  • the components of the traditional Chinese medicine composition for de-population and blood circulation are as follows:
  • Lithospermum 5 parts, Salvia: 2 parts, white peony: 3 parts, silkworm: 3 parts, red peony: 3 parts, hematoxylin: 3 parts, safflower: 2 parts, Chuanpu: 3 parts, loofah: 3 Parts, fragrant: 2 parts, psyllium: 2 parts, tortoise shell: 3 parts.
  • the traditional Chinese medicine composition for de-population and blood circulation in the above Examples 1-15 is preferably prepared by the following method:
  • each batch of 20g is mixed for the first time.
  • the time for the first powdering is 30 s ⁇ 35 s, forming a mixture AA;
  • the mixture AA is re-pulverized, the time of re-pulping is 90 s ⁇ 95 s, forming a mixture BB;
  • the above-mentioned powdering time can be adjusted according to the overall weight of the traditional Chinese medicine composition.
  • the prepared Chinese medicine ointment can be directly applied to the user's face for 20 minutes, and the water can be washed; in order to enhance the skin's metabolism and achieve heat retention.
  • the effect of skin and delicate skin has been achieved after repeated use to achieve the effects of qi and blood harmony, liver dispelling stagnation, promoting blood circulation and removing phlegm and nourishing the face, and significantly improving the facial skin of the user.
  • the traditional Chinese medicine composition for de-population and blood circulation in the above Examples 1-15 can also be prepared by the following method:
  • each batch of 20g is mixed for the first time.
  • the time for the first powdering is 45 s ⁇ 50 s, forming a mixture AA';
  • the mixture AA' is re-pulverized, the time of re-pulping is 75 s ⁇ 80 s, forming a mixture BB';
  • the user When the user uses the above cream, it can be directly applied to the face, and can be rinse-free after use.
  • the skin care can be done once in the morning and evening, which can effectively prevent the skin from being dry; after repeated use, the effect of removing spots and promoting blood circulation can be achieved.
  • the face is yellowish brown or dark brown patches.
  • the area of the melasma is more than 50%-90%, and the color is obviously lighter, close to the normal skin tone.
  • Case 1 Patient Chen, female, 39 years old, has developed symptoms in November 2009: facial spots, pregnancy spots and chloasma, facial skin oil is severe, and the area of chloasma is on the cheeks. More than 50%.
  • the application of the traditional Chinese medicine ointment is applied once a day, and after 1 month of application, the oil on the face is obviously relieved, the color of the chloasma is obviously lightened, and the area of the chloasma is more than 50%; After the month, the oil on the face almost disappeared, the area of the melasma disappeared more than 90%, and the color faded to the normal skin color. After 2 years of follow-up, no recurrence was observed.
  • Case 2 Patient Zhang, female, 30 years old, housewife, the symptoms of the baby just born in January 2010: a lot of pregnancy spots and chloasma, which caused the patient's mood to be extremely depressed.
  • the traditional Chinese medicine ointment to the present invention, once a day, after 1 month of application, the color of the chloasma is obviously lightened, the area of the chloasma is more than 65%; after 3 months of application, the skin becomes white, the patient The mood became better, and the area of the melasma disappeared more than 93%, which obviously faded to normal skin color. After 1.5 years of follow-up, no recurrence was observed.
  • Case 3 Patient Xu, female, 28 years old, symptoms in July 2012: The patient needs a computer office for work, a few spots on the face, a thin layer of facial skin, and a red face on the face.
  • Applying the cream of the present invention applying once a day, after applying for 1 month, the color of the chloasma is obviously lightened, and the skin is smooth, and the area of the chloasma is more than 70%; after applying for 3 months, the skin becomes changed.

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Abstract

一种用于去斑活血的中药组合物及其制备方法，所述组合物由下列重量份的原料制成：紫草3-8、丹参1-5、白芷1-5、僵蚕1-4、赤芍1-4、苏木1-5、红花1-5、川朴1-5、丝瓜络1-5、香附1-5、车前子1-3、龟甲1-7。

Description

用于去斑活血的中药组合物及其制备方法
技术领域
本发明涉及医学技术领域，尤其涉及一种用于去斑活血的中药组合物及其制备方法。
背景技术
黄褐斑俗称蝴蝶斑，中医上又称“面上杂症”，中医机理为邪犯肌肤、气血不和、肝郁气滞、气滞血瘀所致。黄褐斑的西医成因是女性内分泌失调，精神压力大等因素造成的，对于皮肤的黄褐斑，主要采用预防与治疗相结合的方法。调理好女性的内分泌环境，保持心情舒畅，以及预防妇科病等是预防黄褐斑的有效手段，而现在的治疗黄褐斑存在这样的误区：去斑只是单纯停留在皮肤表面，用一些去角质化的化妆品等，甚至有些患者对于去斑更急切，选择见效快的剥脱法去斑，严重损害使用者自身的皮肤表层。针对上述情况，市场上也有大量汤剂胶囊问世，但是其疗效难以保持，形成一种长期需要治疗的现状。
发明内容
本发明的目的在于提供一种用于去斑活血的中药组合物及其制备方法，作用温和、起效持久，能够明显改善黄褐斑症状；对于刚起斑的年轻女性，可以达到去斑的效果。
为实现上述目的，本发明提供一种用于去斑活血的中药组合物，所述中药组合物由以下重量份组成：
紫草：3~8份，丹参：1~5份，白芷：1~5份，僵蚕：1~4份，赤芍：1~4份，苏木：1~5份，红花：1~5份，川朴：1~5份，丝瓜络：1~5份，香附：1~5份，车前子：1~3份，龟甲：1~7份。
优选地，所述中药组合物由以下重量份组成：
紫草：3~6份，丹参：1~3份，白芷：1~3份，僵蚕：1~3份，赤芍：1~3份，苏木：1~3份，红花：1~3份，川朴：1~3份，丝瓜络：1~3份，香附：1~3份，车前子：1~3份，龟甲：1~5份。
优选地，所述中药组合物由以下重量份组成：
紫草：4~6份，丹参：2~3份，白芷：2~3份，僵蚕：2~3份，赤芍：2~3份，苏木：2~3份，红花：2~3份，川朴：2~3份，丝瓜络：2~3份，香附：2~3份，车前子：2~3份，龟甲：2~5份。
优选地，所述中药组合物由以下重量份组成：
紫草：6份，丹参：2份，白芷：2份，僵蚕：3份，赤芍：3份，苏木：2份，红花：2份，川朴：3份，丝瓜络：3份，香附：2份，车前子：2份，龟甲：2份。
优选地，所述中药组合物由以下重量份组成：
紫草：6份，丹参：3份，白芷：3份，僵蚕：2份，赤芍：2份，苏木：3份，红花：3份，川朴：2份，丝瓜络：2份，香附：3份，车前子：3份，龟甲：2份。
优选地，所述中药组合物由以下重量份组成：
紫草：4份，丹参：2份，白芷：2份，僵蚕：3份，赤芍：3份，苏木：2份，红花：2份，川朴：3份，丝瓜络：3份，香附：2份，车前子：2份，龟甲：2份。
优选地，所述中药组合物由以下重量份组成：
紫草：4份，丹参：3份，白芷：3份，僵蚕：2份，赤芍：2份，苏木：3份，红花：3份，川朴：2份，丝瓜络：2份，香附：3份，车前子：3份，龟甲：2份。
优选地，所述中药组合物由以下重量份组成：
紫草：5份，丹参：3份，白芷：3份，僵蚕：2份，赤芍：2份，苏木：3份，红花：3份，川朴：2份，丝瓜络：2份，香附：3份，车前子：3份，龟甲：3份。
优选地，所述中药组合物由以下重量份组成：
紫草：5份，丹参：3份，白芷：2份，僵蚕：2份，赤芍：3份，苏木：2份，红花：2份，川朴：3份，丝瓜络：3份，香附：2份，车前子：2份，龟甲：2份。
优选地，所述中药组合物由以下重量份组成：
紫草：5份，丹参：3份，白芷：3份，僵蚕：2份，赤芍：2份，苏木：3份，红花：3份，川朴：3份，丝瓜络：2份，香附：3份，车前子：2份，龟甲：2份。
优选地，所述中药组合物由以下重量份组成：
紫草：5份，丹参：2份，白芷：2份，僵蚕：3份，赤芍：3份，苏木：2份，红花：2份，川朴：3份，丝瓜络：3份，香附：2份，车前子：3份，龟甲：3份。
优选地，所述中药组合物由以下重量份组成：
紫草：5份，丹参：3份，白芷：2份，僵蚕：2份，赤芍：3份，苏木：2份，红花：3份，川朴：3份，丝瓜络：3份，香附：2份，车前子：2份，龟甲：3份。
优选地，所述中药组合物由以下重量份组成：
紫草：5份，丹参：2份，白芷：3份，僵蚕：3份，赤芍：3份，苏木：3份，红花：2份，川朴：3份，丝瓜络：3份，香附：2份，车前子：2份，龟甲：3份。
此外，为实现上述目的，本发明还提供一种用于去斑活血的中药组合物的制备方法，所述制备方法包含以下步骤：
A、将紫草、丹参、白芷、僵蚕、赤芍、苏木、红花、川朴、丝瓜络、香附、车前子、龟甲各中药按照上述配比，每份20g混合进行初次打粉，初次打粉的时间为30 s~35 s，形成混合物AA；
B、将所述混合物AA进行再次打粉，再次打粉的时间为90 s~95 s，形成混合物BB；
C、将所述混合物BB与蜂蜜调匀制成中药膏，且所述混合物BB与蜂蜜的比例为1:3。
此外，为实现上述目的，本发明提供一种用于去斑活血的中药组合物的制备方法，所述制备方法还可以包含以下步骤：
A、将紫草、丹参、白芷、僵蚕、赤芍、苏木、红花、川朴、丝瓜络、香附、车前子、龟甲各中药按照上述配比，每份20g混合进行初次打粉，初次打粉的时间为45 s~50 s，形成混合物AA’；
B、将所述混合物AA’进行再次打粉，再次打粉的时间为75 s~80 s，形成混合物BB’；
C、将所述混合物BB’与甘油调匀，且所述混合物BB’与甘油的比例为1:2.5，形成混合物CC’；
D、将所述混合物CC’与纯水以1:12.5的比例混匀制成面霜DD’。
本发明以紫草、丹参、白芷、僵蚕、赤芍、苏木、红花、川朴、丝瓜络、香附、车前子、龟甲为药物组份，通过它们协同作用起到气血调和、疏肝解郁、活血化瘀和去斑养颜的功效，能够明显改善黄褐斑症状，提高了患者的生活质量；对于刚起斑的年轻女性，可以达到去斑的效果；对于妊娠斑、老年斑、黄褐斑等可以达到淡化的效果。
具体实施方式
下面结合具体实施例对本发明做进一步的详细说明，以下实施例是对本发明的解释，本发明并不局限于以下实施例。
本发明提供的用于去斑活血的中药组合物，所述中药组合物由以下重量份组成：
紫草：3~8份，丹参：1~5份，白芷：1~5份，僵蚕：1~4份，赤芍：1~4份，苏木：1~5份，红花：1~5份，川朴：1~5份，丝瓜络：1~5份，香附：1~5份，车前子：1~3份，龟甲：1~7份。
在上述组份中：
紫草：性寒，味甘、咸；具有凉血、活血和解毒透疹的功效；用于血热毒盛、斑疹紫黑、疮疡、湿疹等症。紫草具有显著的去痘和消炎的效果，有很大的美容价值，紫草主要功能为凉血，活血化瘀，解毒透疹，因此能加速痘印、疤痕和斑痕的新陈代谢，从而对面部皮肤起到良好的杀菌消炎作用。
丹参：苦性、微寒；归心、心包、肝经；丹参具有养血安神和去斑活血的功效；用于烦热、精神不佳和心悸不眠。女性面部肤色暗沉、甚至色斑的成因，除与肺热、肝郁、阴虚等原因有关外，皆离不开气滞血淤。丹参能活血养血、祛淤生新，调节组织修复和再生，改善面部微循环，使气血运行通畅，上荣于面部，使面部毛细血管得已充养。
白芷又名香白芷；味辛，性温，归肺、脾、胃、大肠经；具有活血排脓和生肌止痛功效；白芷粉《本草纲目》谓白芷“长肌肤，润泽颜色，可作面脂”，用于皮肤瘙痒、痈疽疮疡等症。白芷对美白去斑有显著的作用，并可改善微循环，促进皮肤的新陈代谢，延缓皮肤衰老。
僵蚕：药性咸、辛、平；主要用于皮肤瘙痒、咽喉肿痛、面神经麻痹等病症；古医书中就有记载“白僵蚕可灭黑斑，令人面色好”，是古代女性美容去斑时常用的一味中药。现代医学研究发现，白僵蚕含有氨基酸、维生素E及活性丝光素等元素，可调节性激素分泌，清除自由基，对于内分泌失调而引起的黄褐斑、抗脂质氧化形成的老年斑等色斑，均具有不错的去斑疗效，同时它还可以加速细胞代谢，改善皮肤微循环，去除肤色暗沉、晒斑，增加皮肤弹性。
赤芍：具有清热凉血、散瘀止痛、泻火去斑的功效；主要用于皮肤长斑、疮痈等症；赤芍由于苦泄，性凉，主入肝经，功能清除血分郁热，而起凉血止血、散瘀消斑之功效。主要治疗血热毒盛，皮肤长斑，色偏紫暗，常与生地黄、牡丹皮、丹参、红花等凉血、活血之品同用。
苏木：性甘、咸、辛凉；为清血剂，具有活血散风和消肿止痛的功效。
常与赤芍、红花、丝瓜络配伍，对肝斑、中毒性黑皮病及面部继发性色素沉着疗效良好。
红花：性温、味辛，具有美容去斑、活血通经的功效；通过活血化瘀，加速血液循环，促进新陈找谢，增加排除黑素细胞所产生的黑色素，促进滞留于体内的黑色素分解，使之不能沉淀形成色斑，或使淀的色素分解而排出体外。
川朴：性温、辛；具有行气消积、燥湿除满的功效；川朴常与苏木、赤芍、红花和丝瓜络协同作用，起到对肝斑、黑皮病及面部继发性色素沉着良好的治疗效果。
丝瓜络：又称祛风药、通络药、清热药、凉血止血药；具有通经活络，解毒消肿的功效；丝瓜当中的皂甙类物质、丝瓜苦味质、黏液质、木胶、瓜氨酸、木聚糖和干扰素等特殊物质具有一定的特殊作用，丝瓜络所含防止皮肤老化的维生素b1，增白皮肤的维生素c等成分，能保护皮肤、消除斑块，使皮肤洁白、细嫩。
香附：具有理气解郁、调经止痛的功效；用于肝郁气滞、月经不调、经闭痛经和乳房胀痛等症。从中医美容的观点来看，理气药能够行散气滞、疏理肝气、顺气降逆、调理脏腑，故对面部黄褐斑、粉刺、水肿等损美性疾病均有调理作用。因此，香附与本方中的其他成分协同作用达到美白去斑、延缓衰老的效果。
车前子：性微寒、甘、淡；具有清热利尿、渗湿止泻和明目的功效；主要用于水肿胀满、暑湿泻痢和目赤障翳等症。
龟甲：微寒、咸、甘；归肝、肾、心经；具有滋阴潜阳、益肾强骨和养血补心的功效；龟甲中含蛋白质（约32%）、骨胶原（collagen）等成分，其中含有天冬氨酸、苏氨酸、蛋氨酸、苯丙氨酸、亮氨酸等多种氨基酸。龟甲对细胞调控系统的影响方面：龟甲为重要滋阴药，大量实验研究结果已证明环核苷酸系统是机体分子水平上的重要调控系统之一，cAMP 及cGMP 在调节细胞功能上有着甚为重要的作用，阴虚或阳虚患者常有环核苷酸系统反应性的相对应改变，阴虚者血浆cAMP 占相对优势，阳虚者则cGMP 占相对优势。龟甲与赤芍、白僵蚕、白芷协同作用能够有效去除面部色斑以及眼眶周围褐青色斑。
服用上述中药组合物，其中的紫草具有凉血、活血和解毒透疹的功效；此外，紫草还具有显著的去痘和消炎的效果，能加速痘印、疤痕和斑痕的新陈代谢，从而对面部皮肤起到良好的杀菌消炎作用；丹参能活血养血、祛淤生新，调节组织修复和再生，改善面部微循环；白芷具有活血排脓和生肌止痛功效，并可改善微循环，促进皮肤的新陈代谢，延缓皮肤衰老；僵蚕主要用于皮肤瘙痒、咽喉肿痛、面神经麻痹等病症；赤芍具有清热凉血、散瘀止痛和泻火去斑的功效，主要用于皮肤长斑、疮痈等症，赤芍常与生地黄、牡丹皮、丹参、红花等凉血、活血之品同用；苏木具有活血散风和消肿止痛的功效，常与赤芍、红花、丝瓜络配伍，对肝斑、中毒性黑皮病及面部继发性色素沉着疗效良好；红花具有美容去斑、活血通经的功效；通过活血化瘀，加速血液循环，促进新陈找谢，使之不能沉淀形成色斑；川朴具有行气消积、燥湿除满的功效，川朴常与苏木、赤芍、红花和丝瓜络协同作用，起到对肝斑、黑皮病及面部继发性色素沉着良好的治疗效果；丝瓜络具有通经活络，解毒消肿的功效，丝瓜络所含防止皮肤老化的维生素b1，增白皮肤的维生素c等成分，能保护皮肤、消除斑块；香附具有理气解郁、调经止痛的功效；用于肝郁气滞、月经不调、经闭痛经和乳房胀痛等症；香附与本方中的其他成分协同作用达到美白去斑、延缓衰老的效果；车前子具有清热利尿、渗湿止泻和明目的功效，主要用于水肿胀满、暑湿泻痢等症；龟甲具有滋阴潜阳、益肾强骨和养血补心的功效；龟甲为重要滋阴药，龟甲与赤芍、白僵蚕、白芷一起水煎服，通过它们协同作用有效治疗面部色斑以及眼眶周围褐青色斑。通过上述药物组份的协同作用起到气血调和、疏肝解郁、活血化瘀和去斑养颜的功效，能够明显改善黄褐斑症状，提高了患者的生活质量；对于刚起斑的年轻女性，可以达到去斑的效果；对于妊娠斑、老年斑、黄褐斑等可以达到淡化的效果。
实施例1
用于去斑活血的中药组合物的组分如下：
紫草：3~7份，丹参：1~4份，白芷：1~3份，僵蚕：1~4份，赤芍：1~4份，苏木：1~5份，红花：1~5份，川朴：1~5份，丝瓜络：1~5份，香附：1~5份，车前子：1~3份，龟甲：1~7份。
实施例2
优选地，所述中药组合物由以下重量份组成：
紫草：3~6份，丹参：1~3份，白芷：1~3份，僵蚕：1~3份，赤芍：1~3份，苏木：1~3份，红花：1~3份，川朴：1~3份，丝瓜络：1~3份，香附：1~3份，车前子：1~3份，龟甲：1~5份。
实施例3
优选地，所述中药组合物由以下重量份组成：
紫草：4~6份，丹参：2~3份，白芷：2~3份，僵蚕：2~3份，赤芍：2~3份，苏木：2~3份，红花：2~3份，川朴：2~3份，丝瓜络：2~3份，香附：2~3份，车前子：2~3份，龟甲：2~5份。
实施例4
优选地，所述中药组合物由以下重量份组成：
紫草：6份，丹参：2份，白芷：2份，僵蚕：3份，赤芍：3份，苏木：2份，红花：2份，川朴：3份，丝瓜络：3份，香附：2份，车前子：2份，龟甲：2份。
实施例5
优选地，所述中药组合物由以下重量份组成：
紫草：6份，丹参：3份，白芷：3份，僵蚕：2份，赤芍：2份，苏木：3份，红花：3份，川朴：2份，丝瓜络：2份，香附：3份，车前子：3份，龟甲：2份。
实施例6
优选地，所述中药组合物由以下重量份组成：
紫草：4份，丹参：2份，白芷：2份，僵蚕：3份，赤芍：3份，苏木：2份，红花：2份，川朴：3份，丝瓜络：3份，香附：2份，车前子：2份，龟甲：2份。
实施例7
优选地，所述中药组合物由以下重量份组成：
紫草：4份，丹参：3份，白芷：3份，僵蚕：2份，赤芍：2份，苏木：3份，红花：3份，川朴：2份，丝瓜络：2份，香附：3份，车前子：3份，龟甲：2份。
实施例8
优选地，所述中药组合物由以下重量份组成：
紫草：5份，丹参：3份，白芷：3份，僵蚕：2份，赤芍：2份，苏木：3份，红花：3份，川朴：2份，丝瓜络：2份，香附：3份，车前子：3份，龟甲：3份。
实施例9
用于去斑活血的中药组合物的组分如下：
紫草：5份，丹参：2份，白芷：2份，僵蚕：3份，赤芍：3份，苏木：2份，红花：2份，川朴：3份，丝瓜络：3份，香附：2份，车前子：2份，龟甲：2份。
实施例10
用于去斑活血的中药组合物的组分如下：
紫草：5份，丹参：3份，白芷：3份，僵蚕：2份，赤芍：2份，苏木：3份，红花：3份，川朴：2份，丝瓜络：2份，香附：3份，车前子：3份，龟甲：2份。
实施例11
用于去斑活血的中药组合物的组分如下：
紫草：5份，丹参：3份，白芷：2份，僵蚕：2份，赤芍：3份，苏木：2份，红花：2份，川朴：3份，丝瓜络：3份，香附：2份，车前子：2份，龟甲：2份。
实施例12
用于去斑活血的中药组合物的组分如下：
紫草：5份，丹参：3份，白芷：3份，僵蚕：2份，赤芍：2份，苏木：3份，红花：3份，川朴：3份，丝瓜络：2份，香附：3份，车前子：2份，龟甲：2份。
实施例13
用于去斑活血的中药组合物的组分如下：
紫草：5份，丹参：2份，白芷：2份，僵蚕：3份，赤芍：3份，苏木：2份，红花：2份，川朴：3份，丝瓜络：3份，香附：2份，车前子：3份，龟甲：3份。
实施例14
用于去斑活血的中药组合物的组分如下：
紫草：5份，丹参：3份，白芷：2份，僵蚕：2份，赤芍：3份，苏木：2份，红花：3份，川朴：3份，丝瓜络：3份，香附：2份，车前子：2份，龟甲：3份。
实施例15
用于去斑活血的中药组合物的组分如下：
紫草：5份，丹参：2份，白芷：3份，僵蚕：3份，赤芍：3份，苏木：3份，红花：2份，川朴：3份，丝瓜络：3份，香附：2份，车前子：2份，龟甲：3份。
以上实施例1-15中的用于去斑活血的中药组合物优选采用下述方法制备：
A、将紫草、丹参、白芷、僵蚕、赤芍、苏木、红花、川朴、丝瓜络、香附、车前子、龟甲各中药按照上述配比，每份20g混合进行初次打粉，初次打粉的时间为30 s~35 s，形成混合物AA；
B、将所述混合物AA进行再次打粉，再次打粉的时间为90 s~95 s，形成混合物BB；
C、将所述混合物BB与蜂蜜调匀制成中药膏，且所述混合物BB与蜂蜜的比例为1:3。
上述打粉的时间可以根据中药组合物的总体重量进行调整。
由于蜂蜜中含有多种对人体有益的氨基酸，在使用时，可将制成的中药膏直接涂于使用者的面部，保持20分钟，清水洗净即可；以便增强肌肤的新陈代谢，达到保温润肤、细腻皮肤的效果，多次坚持使用后达到气血调和、疏肝解郁、活血化瘀和去斑养颜的功效，明显改善使用者的面部皮肤。
以上实施例1-15中的用于去斑活血的中药组合物也可采用下述方法制备：
A、将紫草、丹参、白芷、僵蚕、赤芍、苏木、红花、川朴、丝瓜络、香附、车前子、龟甲各中药按照上述配比，每份20g混合进行初次打粉，初次打粉的时间为45 s~50 s，形成混合物AA’；
B、将所述混合物AA’进行再次打粉，再次打粉的时间为75 s~80 s，形成混合物BB’；
C、将所述混合物BB’与甘油调匀，且所述混合物BB’与甘油的比例为1:2.5，形成混合物CC’；
D、将所述混合物CC’与纯水以1:12.5的比例混匀制成面霜DD’。
使用者在使用上述面霜时，可直接涂于面部，且使用后可免洗，早晚各一次护肤即可，可有效阻止肌肤干燥；多次使用后可以达到去斑活血的效果。
临床疗效总结：
一、一般资料：共治疗面部有斑的女性38例；年龄30-35岁15例，36-45岁18例，46岁以上5例。
二、诊断标准：
症状：面部呈黄褐色或深褐色斑片。
三、疗效评定标准：
1、好转：黄褐斑消褪面积大于90%，且颜色明显消褪至正常肤色，一年内不复发。
2、有效：黄褐斑消褪面积大于50%-90%，且颜色明显变淡，接近正常肤色。
四、使用结果：使用一月为一疗程，轻者二疗程好转，重者三至五疗程好转。有效率93%，好转率60%。
五、典型病例：
病例1：患者陈某，女，39岁，已育，2009年11月时的症状：面部出现色斑、妊娠斑和黄褐斑，面部皮肤出油严重，且黄褐斑的面积占脸颊部的50%以上。给予本发明中药膏敷用，每日敷用1次，敷用1月之后，脸上出油现象明显减轻，黄褐斑颜色明显变淡，黄褐斑消褪面积大于50%；敷用5月之后，脸上出油现象几乎消失，黄褐斑消褪面积大于90%，颜色明显消褪至正常肤色，随访2年，未见复发。
病例2： 患者张某，女，30岁，家庭主妇，2010年1月刚生完宝宝时的症状：面部长了不少妊娠斑和黄褐斑，导致患者心情极度郁闷。给予本发明中药膏敷用，每日敷用1次，敷用1月之后，黄褐斑颜色明显变淡，黄褐斑消褪面积大于65%；敷用3月之后，皮肤变白，患者心情变好，且黄褐斑消褪面积大于93%，明显消褪至正常肤色，随访1.5年，未见复发。
病例3：患者徐某，女，28岁，2012年7月时的症状：患者因工作需要电脑办公，面部长了不少斑，面部皮肤层也较薄，且面部充红血丝。给予本发明面霜敷用，每日贴敷1次，敷用1月之后，黄褐斑颜色明显变淡，且皮肤光滑，黄褐斑消褪面积大于70%；敷用3月之后，皮肤变白，且黄褐斑消褪面积大于95%，明显消褪至正常肤色，随访1.5年，未见复发。
上述病例证明该方中的各组份协同作用起到气血调和、疏肝解郁和活血化瘀的功效，能够明显改善黄褐斑症状，提高了患者的生活质量；对于刚起斑的年轻女性，可以达到去斑的效果；对于妊娠斑、老年斑、黄褐斑等可以达到淡化的效果。
以上仅为本发明的优选实施例，并非因此限制本发明的专利范围，凡是利用本发明说明书所作的等效结构或等效流程变换，或直接或间接运用在其他相关的技术领域，均同理包括在本发明的专利保护范围内。

Claims (15)

  1. 一种用于去斑活血的中药组合物，其特征在于，所述中药组合物由以下重量份组成：
    紫草：3~8份，丹参：1~5份，白芷：1~5份，僵蚕：1~4份，赤芍：1~4份，苏木：1~5份，红花：1~5份，川朴：1~5份，丝瓜络：1~5份，香附：1~5份，车前子：1~3份，龟甲：1~7份。
  2. 如权利要求1所述的用于去斑活血的中药组合物，其特征在于，所述中药组合物由以下重量份组成：
    紫草：3~6份，丹参：1~3份，白芷：1~3份，僵蚕：1~3份，赤芍：1~3份，苏木：1~3份，红花：1~3份，川朴：1~3份，丝瓜络：1~3份，香附：1~3份，车前子：1~3份，龟甲：1~5份。
  3. 如权利要求1所述的用于去斑活血的中药组合物，其特征在于，所述中药组合物由以下重量份组成：
    紫草：4~6份，丹参：2~3份，白芷：2~3份，僵蚕：2~3份，赤芍：2~3份，苏木：2~3份，红花：2~3份，川朴：2~3份，丝瓜络：2~3份，香附：2~3份，车前子：2~3份，龟甲：2~5份。
  4. 如权利要求1所述的用于去斑活血的中药组合物，其特征在于，所述中药组合物由以下重量份组成：
    紫草：6份，丹参：2份，白芷：2份，僵蚕：3份，赤芍：3份，苏木：2份，红花：2份，川朴：3份，丝瓜络：3份，香附：2份，车前子：2份，龟甲：2份。
  5. 如权利要求1所述的用于去斑活血的中药组合物，其特征在于，所述中药组合物由以下重量份组成：
    紫草：6份，丹参：3份，白芷：3份，僵蚕：2份，赤芍：2份，苏木：3份，红花：3份，川朴：2份，丝瓜络：2份，香附：3份，车前子：3份，龟甲：2份。
  6. 如权利要求1所述的用于去斑活血的中药组合物，其特征在于，所述中药组合物由以下重量份组成：
    紫草：4份，丹参：2份，白芷：2份，僵蚕：3份，赤芍：3份，苏木：2份，红花：2份，川朴：3份，丝瓜络：3份，香附：2份，车前子：2份，龟甲：2份。
  7. 如权利要求1所述的用于去斑活血的中药组合物，其特征在于，所述中药组合物由以下重量份组成：
    紫草：4份，丹参：3份，白芷：3份，僵蚕：2份，赤芍：2份，苏木：3份，红花：3份，川朴：2份，丝瓜络：2份，香附：3份，车前子：3份，龟甲：2份。
  8. 如权利要求1所述的用于去斑活血的中药组合物，其特征在于，所述中药组合物由以下重量份组成：
    紫草：5份，丹参：3份，白芷：3份，僵蚕：2份，赤芍：2份，苏木：3份，红花：3份，川朴：2份，丝瓜络：2份，香附：3份，车前子：3份，龟甲：3份。
  9. 如权利要求1所述的用于去斑活血的中药组合物，其特征在于，所述中药组合物由以下重量份组成：
    紫草：5份，丹参：3份，白芷：2份，僵蚕：2份，赤芍：3份，苏木：2份，红花：2份，川朴：3份，丝瓜络：3份，香附：2份，车前子：2份，龟甲：2份。
  10. 如权利要求1所述的用于去斑活血的中药组合物，其特征在于，所述中药组合物由以下重量份组成：
    紫草：5份，丹参：3份，白芷：3份，僵蚕：2份，赤芍：2份，苏木：3份，红花：3份，川朴：3份，丝瓜络：2份，香附：3份，车前子：2份，龟甲：2份。
  11. 如权利要求1所述的用于去斑活血的中药组合物，其特征在于，所述中药组合物由以下重量份组成：
    紫草：5份，丹参：2份，白芷：2份，僵蚕：3份，赤芍：3份，苏木：2份，红花：2份，川朴：3份，丝瓜络：3份，香附：2份，车前子：3份，龟甲：3份。
  12. 如权利要求1所述的用于去斑活血的中药组合物，其特征在于，所述中药组合物由以下重量份组成：
    紫草：5份，丹参：3份，白芷：2份，僵蚕：2份，赤芍：3份，苏木：2份，红花：3份，川朴：3份，丝瓜络：3份，香附：2份，车前子：2份，龟甲：3份。
  13. 如权利要求1所述的用于去斑活血的中药组合物，其特征在于，所述中药组合物由以下重量份组成：
    紫草：5份，丹参：2份，白芷：3份，僵蚕：3份，赤芍：3份，苏木：3份，红花：2份，川朴：3份，丝瓜络：3份，香附：2份，车前子：2份，龟甲：3份。
  14. 一种如权利要求1所述的用于去斑活血的中药组合物的制备方法，其特征在于，所述制备方法包含以下步骤：
    A、将紫草、丹参、白芷、僵蚕、赤芍、苏木、红花、川朴、丝瓜络、香附、车前子、龟甲各中药按照上述配比，每份20g混合进行初次打粉，初次打粉的时间为30 s~35 s，形成混合物AA；
    B、将所述混合物AA进行再次打粉，再次打粉的时间为90 s~95 s，形成混合物BB；
    C、将所述混合物BB与蜂蜜调匀制成中药膏，且所述混合物BB与蜂蜜的比例为1:3。
  15. 一种如权利要求1所述的用于去斑活血的中药组合物的制备方法，其特征在于，所述制备方法包含以下步骤：
    A、将紫草、丹参、白芷、僵蚕、赤芍、苏木、红花、川朴、丝瓜络、香附、车前子、龟甲各中药按照上述配比，每份20g混合进行初次打粉，初次打粉的时间为45 s~50 s，形成混合物AA’；
    B、将所述混合物AA’进行再次打粉，再次打粉的时间为75 s~80 s，形成混合物BB’；
    C、将所述混合物BB’与甘油调匀，且所述混合物BB’与甘油的比例为1:2.5，形成混合物CC’；
    D、将所述混合物CC’与纯水以1:12.5的比例混匀制成面霜DD’。
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111568828A (zh) * 2020-05-26 2020-08-25 陈志峰 一种祛斑祛痘安全有效无副作用配方及技术
CN115487248A (zh) * 2022-09-06 2022-12-20 黄东香 一种皮肤再生修复组合物及其制备工艺

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104997997A (zh) * 2015-07-30 2015-10-28 深圳市前海安测信息技术有限公司 用于去斑活血的中药组合物及其制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1096195A (zh) * 1993-06-10 1994-12-14 周幼安 中药膏状祛斑面膜的制备方法和用途
CN101732683A (zh) * 2009-12-25 2010-06-16 卢速江 一种治疗面部黄褐斑的中药制剂及其制备方法
CN104997997A (zh) * 2015-07-30 2015-10-28 深圳市前海安测信息技术有限公司 用于去斑活血的中药组合物及其制备方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1096195A (zh) * 1993-06-10 1994-12-14 周幼安 中药膏状祛斑面膜的制备方法和用途
CN101732683A (zh) * 2009-12-25 2010-06-16 卢速江 一种治疗面部黄褐斑的中药制剂及其制备方法
CN104997997A (zh) * 2015-07-30 2015-10-28 深圳市前海安测信息技术有限公司 用于去斑活血的中药组合物及其制备方法

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111568828A (zh) * 2020-05-26 2020-08-25 陈志峰 一种祛斑祛痘安全有效无副作用配方及技术
CN115487248A (zh) * 2022-09-06 2022-12-20 黄东香 一种皮肤再生修复组合物及其制备工艺

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