WO2016058194A1 - 治疗更年期综合症的中药组合物及其制备方法 - Google Patents
治疗更年期综合症的中药组合物及其制备方法 Download PDFInfo
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- WO2016058194A1 WO2016058194A1 PCT/CN2014/088942 CN2014088942W WO2016058194A1 WO 2016058194 A1 WO2016058194 A1 WO 2016058194A1 CN 2014088942 W CN2014088942 W CN 2014088942W WO 2016058194 A1 WO2016058194 A1 WO 2016058194A1
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Definitions
- the invention relates to the field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition for treating climacteric syndrome and a preparation method thereof.
- Menopausal syndrome refers to a series of syndromes caused by fluctuations or reductions in sex hormones before and after menopause in women, with autonomic nervous system dysfunction and neuropsychological symptoms. The main symptoms are hot flashes and flushing.
- Chinese medicine treatment of menopausal syndrome mostly using spleen and kidney, Qi and nourishing blood, to solve the problem of menstrual kidney Qi decline, lack of blood.
- menopausal drugs There are various treatments for menopausal drugs on the market, but the curative effect is not clear.
- menopause lasts for a long time, some patients need to relieve menopausal symptoms through uninterrupted medication, some drugs are too expensive, patients may be interrupted during treatment, leading to repeated illness.
- the main object of the present invention is to solve the technical problem of the inaccurate and expensive price of the existing drugs for treating menopausal syndrome.
- the present invention provides a traditional Chinese medicine composition for treating climacteric syndrome, wherein the components and parts by weight of the traditional Chinese medicine composition for treating menopausal syndrome are:
- the components and parts by weight of the traditional Chinese medicine composition for treating menopausal syndrome are:
- the components and parts by weight of the traditional Chinese medicine composition for treating menopausal syndrome are:
- the components and parts by weight of the traditional Chinese medicine composition for treating menopausal syndrome are:
- the present invention also provides a preparation method of the above traditional Chinese medicine composition for treating menopausal syndrome, comprising the following steps:
- the components are ground into a powder and then placed in a cotton bag;
- the drug solution A, the drug solution B, and the drug solution C are mixed to prepare a drug solution D for use.
- the method for preparing a traditional Chinese medicine composition for treating climacteric syndrome further comprises the following steps:
- the drug solution D is placed in a centrifuge at 3500 ⁇ 5000 Centrifuge at rpm for 30 to 60 minutes to obtain a liquid E that is divided into a pale yellow transparent layer and a dark layer;
- the dark layer liquid in the liquid E is taken out and sealed and packaged for use.
- the method for preparing a traditional Chinese medicine composition for treating climacteric syndrome further comprises the following steps:
- the drug solution D is directly decocted in a container, and the drug solution D is volatilized to obtain a drug solution E', the drug solution E' capacity is 2/3 of the capacity of the drug solution D;
- the drug solution E' is taken out and sealed and packaged for use.
- the cotton bag is placed in normal temperature water to soak, and boil the water at room temperature, and then boiled, and the liquid medicine A is poured out into the standby step, the amount of the normal temperature water is 7 of the total weight of each component. ⁇ 10 times, the soaking time is 25 ⁇ 35 minutes, the normal temperature water is boiled by martial arts and then transferred to a simmering simmer, wherein the simmering time is 5-8 minutes.
- the soaking time is 30 minutes and the simmering time is 5 minutes.
- the normal temperature water is added to the cotton bag, and the water is boiled at room temperature, and then boiled, and the liquid B is poured out into the standby step, and the amount of the normal temperature water is 7 to 10 times the total weight of each component.
- the normal temperature water is boiled by martial arts and then tempered to a simmer, wherein the simmering time is 10 to 12 minutes.
- the simmering time is 10 minutes.
- the water bag is soaked in a normal temperature water and boiled at room temperature, and then boiled, and the liquid C is poured out into a standby step, wherein the amount of the normal temperature water is 7 to 10 of the total weight of each component. Times, the room temperature water is boiled to a simmer and boiled, and the simmering time is 15 to 18 minutes.
- the simmering time is 15 minutes.
- the traditional Chinese medicine composition for treating climacteric syndrome of the present invention and the preparation method thereof adopt ordinary Chinese medicine materials, and the cost thereof is low; and the effective rate of using the traditional Chinese medicine composition for treating menopausal syndrome is 91.3%, and the cure rate is 82.6%, The treatment effect is exact and the therapeutic effect of the cure is achieved.
- the preparation method of the traditional Chinese medicine composition for treating menopausal syndrome is simple, high in efficiency, and is also beneficial for the preservation and extraction of the active ingredient of the medicine.
- the invention provides a traditional Chinese medicine composition for treating climacteric syndrome, wherein the components and parts of the traditional Chinese medicine composition for treating climacteric syndrome are:
- Polygonum multiflorum liver, kidney, nourishing, hurricane. Treatment of liver and kidney yin deficiency, hair must be early white, blood deficiency dizziness, weak waist and knees, muscle aches and pains, nocturnal emission, collapse, long malaria, long time, chronic hepatitis, bloated, phlegm, intestinal wind, dysentery.
- Kudingcha Dispelling wind and heat, clearing the head, in addition to polydipsia. Treat headache, toothache, red eyes, pus, fever, polydipsia, dysentery.
- Acacia skin Jieyu, and blood, Ningxin, eliminate swelling. Treating the mind and heart, restlessness, insomnia, lung sputum, carbuncles, phlegm, skeletal fractures.
- Loquat leaves tonic and essence, heat, thirst, hurricane and eyesight. Treatment of fatigue, fever, polydipsia, dizziness, blindness, blindness, uterine bleeding, heat and sore.
- Chrysanthemum Pinggan Mingmu, scattered wind and heat, cough and pain. It is used to treat headache, dizziness, redness and swelling, wind and heat, and cough.
- Eucommia liver and kidney, strong bones, and fetus. Treatment of lumbar pain, pain in the knees, urinary leaching, wet itching under the yin, fetal leakage, fetal movement, high blood pressure.
- Dodder Replenish liver and kidney, benefit essence, eyesight. Treatment of waist and knee pain, nocturnal emission, thirst, urine, and dark eyes.
- Chenpi qi, tune, dampness, phlegm. Treat chest and abdomen fullness, do not think about diet, vomiting hiccups, cough more. Also solve fish and crab poison.
- Eclipta prostrata nourish liver and kidney, cool blood to stop bleeding.
- Angelica blood and blood, regulate menstruation and relieve pain, moisten and dry the intestine.
- Ophiopogon nourishing yin and fluid, moistening the lungs and clearing the heart.
- Deficiency cough Tianjin wound thirst, upset insomnia, internal heat and thirst, intestinal dry constipation; throat diphtheria.
- Treatment of dry lung cough vomiting blood, hemoptysis, lung sputum, lung sputum, fatigue, heat, thirst, fever, zinc injury, dry throat, constipation.
- the pharmacology of the traditional Chinese medicine composition for treating climacteric syndrome of the present invention is as follows: "Su Wen ⁇ The Ancient Innocent Theory" has said that the woman is in the twenty-seventh day, the seven-seventh is the pulse, the dying pulse is less, the heaven is exhausted, and the tunnel is unreasonable. It is bad and has no children.
- the traditional meaning of the traditional Chinese medicine composition for treating climacteric syndrome of the present invention is as follows: the combination of tonifying liver and kidney and tonifying blood, relieving stagnation of stagnation, cooling blood and soothe the nerves.
- Ligustrum lucidum Shouwu, medlar, Eucommia, Dodder, Danggui supplement liver and kidney nourishing; Ophiopogon japonicus, Eclipta gracilis; Kuding, Danpi Qingreliangxue; orange peel, chrysanthemum qi evacuation, Acacia Jie Yu; a total of tonic liver and kidney, cold serum heat, Jie Yu An Shen effect.
- the components and parts by weight of the traditional Chinese medicine composition for treating menopausal syndrome are:
- the components and parts by weight of the traditional Chinese medicine composition for treating menopausal syndrome are:
- the components and parts by weight of the traditional Chinese medicine composition for treating menopausal syndrome are:
- the invention also provides a preparation method of the above traditional Chinese medicine composition for treating menopausal syndrome, comprising the following steps:
- each component was ground into a powder and then placed in a cotton bag.
- each component is ground into a powder by a grinding device.
- the cotton bag is preferably a gauze bag.
- the drug solution D Places the drug solution D in a centrifuge at 3500 ⁇ 5000 Centrifuge at rpm for 30 to 60 minutes to obtain a liquid E which is divided into a pale yellow transparent layer and a dark layer; the dark layer liquid in the liquid E is taken out and sealed and packaged for use.
- the drug solution D is directly placed in a container to be boiled, and the drug solution D is volatilized to obtain a drug solution E'.
- the volume of the drug solution E' is 2/3 of the volume of the drug solution D; the drug solution E' is taken out and sealed and packaged for use.
- the above packaging method is to pack a bag of 500 ml, and then seal it for use.
- the above preparation method is simple, high in efficiency, and is favorable for preservation and extraction of active ingredients of the medicine.
- the gauze bag containing the powdered traditional Chinese medicine component is placed in a casserole containing 5.81 to 8.30 Kg of normal temperature water for 30 minutes, the room temperature water is preferably 6 Kg, and the medicinal material absorbs about 1600 g of water;
- the drug solution D was purified and concentrated:
- the dark layer liquid in the liquid E is taken out, and it is assumed that the normal temperature water added each time is 6 kg.
- the dark layer liquid in the liquid E is about 8Kg, that is, 8000ml, and is packaged in 500ml, a total of 16 packs, and then sealed for use;
- the drug solution D was purified and concentrated:
- the volume of the drug solution E' is 2/3 of the capacity of the drug solution D; assuming that the normal temperature water added each time is 6 Kg, the last
- the drug solution E' obtained by the evaporation method has a lower concentration of the dark layer liquid of the drug solution E obtained by the centrifugation method of the above-mentioned Example 2, and the preparation time is long, but the utilization rate of the drug is high.
- the use of skin secretion, absorption, penetration and other functions can enable drugs through the skin surface absorption, stratum corneum penetration and dermal layer transport, into the blood circulation directly to the lesion, to ensure the full absorption of the drug, but also avoid the drug on the stomach Intestinal damage.
- the traditional Chinese medicine composition of the present embodiment is selected for use by the patient once a day, 30 days is a course of treatment, and 2 courses are continuously used.
- Case 1 Ding Mou, female, 48 years old.
- the patient has menstrual disorders in 2 years, once every 15 ⁇ 18 days, lasting 4 ⁇ 5 days, the amount is much, the color is red, there is a block, and with dizziness, tinnitus, palpitations, insomnia, irritability, irritability, sweating, Zeng
- the effects of oryzanol, vitamins, diazepam, and aging are not obvious.
- the symptoms before using the traditional Chinese medicine composition are: menstrual cycle disorder, dizziness, heart palpitations, forgetfulness, insomnia, tinnitus, hot and sweating, irritability, irritability, good sentiment, red tongue, thin yellowish tongue coating, fine pulse string.
- the traditional Chinese medicine composition of the present invention once a day, after one course of treatment, the symptoms are obviously improved, and the two steps of the foot are continued, and the treatment is cured. No recurrence was seen during 1 year of follow-up.
- Case 2 Yin Mou, female, 49 years old.
- the patient has irregular menstruation in the past 1 year, accompanied by palpitations, insomnia, fatigue, irritability, heat and sweat, memory loss, poor appetite, dry stool, 5 to 6 days, the tongue is reddish, The moss is thin and the pulse is fine. Diagnosed as menopausal syndrome.
- the traditional Chinese medicine composition of the present invention once a day, after one course of treatment, the symptoms are obviously improved, and one course of treatment is continued and healed. There was no recurrence after 6 months of follow-up.
- Case 3 Sun Moumou, female, 47 years old, teacher. A year ago, due to menorrhagia, hysterectomy for uterine fibroadenomas, due to more concerns about surgery, there were emotional abnormalities after surgery, depression, forgetfulness, crying, palpitations, insomnia, poor appetite, stool God is weak, the tongue is reddish, the fur is white, and the pulse is fine.
- the traditional Chinese medicine composition of the present invention once a day, after one course of treatment, the patient's sleep improved, the spirit improved compared with the previous one, and the two treatment courses were continued, the spirit was full, the mood was stable, the sleep was good, and the urine was normal. No recurrence was seen during the follow-up period of six months
- Case 4 Li, female, 51 years old, cadre.
- the patient has a menstrual disorder in the past year, or first or later, the amount of time is too long, the sweat is too much at night, irritability, unable to sleep, dark complexion, cold limbs, cold fatigue, weak waist and knees, poor appetite, face
- the floating limbs are swollen, the tongue is pale, and there are teeth marks, the fur is white, and the veins are fine.
- the traditional Chinese medicine composition of the present invention once a day, after one course of treatment, the symptoms of the patient are all improved, and one course of treatment is continued, and the symptoms disappear. No recurrence was seen during the follow-up period of six months
- Case 5 Wang, 40 years old, irregular menstruation, sweating, palpitations, emotional instability, suspicion and irritability in the past six months, the patient is very painful, using the traditional Chinese medicine composition of the present invention once a day, after a course of treatment, the symptoms are basically Disappeared, the symptoms disappeared completely after two courses of treatment, followed up for 6 months, regular menstruation, emotional stability, good sleep, patient satisfaction. No recurrence was seen during the follow-up period of six months
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Abstract
一种治疗更年期综合症的中药组合物及其制备方法，所述组合物的组分及重量份为：何首乌95-105份，女贞子115-125份，苦丁茶15-25份，合欢皮115-125份，枸杞叶115-125份，菊花35-45份，杜仲55-65份，菟丝子55-65份，陈皮75-85份，丹皮15-25份，旱莲草25-35份，当归25-35份，麦冬25-35份。
Description
技术领域
本发明涉及中药领域，尤其涉及一种治疗更年期综合症的中药组合物及其制备方法。
背景技术
更年期综合症是指妇女绝经前后出现性激素波动或减少所致的一系列以自主神经系统功能紊乱为主，伴有神经心理症状的一组症候群，表现出的主要症状是潮热、潮红。目前，中医治疗更年期综合症，大多采用健脾补肾、益气养血的方法，解决更年期肾气渐衰，精血不足的问题。现有市面上的治疗更年期药物五花八门，但疗效大都不确切。另外，更年期的持续时间较久，部分患者需要通过不间断的服药来缓解更年期症状，有些药物的价格太贵，患者可能在治疗时出现间断，导致病情反复。
发明内容
本发明的主要目的在于解决现有的治疗更年期综合症的药物的疗效不确切，价格昂贵的技术问题。
为实现上述目的，本发明提供一种治疗更年期综合症的中药组合物，所述治疗更年期综合症的中药组合物的组分及重量份为：
何首乌95~105重量份、女贞子115~125重量份、苦丁茶15~25重量份、合欢皮115~125重量份、枸杞叶115~125重量份、菊花35~45重量份、杜仲55~65重量份、菟丝子55~65重量份、陈皮75~85重量份、丹皮15~25重量份、旱莲草25~35重量份、当归25~35重量份以及麦冬25~35重量份。
优选地，所述治疗更年期综合症的中药组合物的组分及重量份为：
何首乌95~100重量份、女贞子115~120重量份、苦丁茶15~20重量份、合欢皮115~120重量份、枸杞叶115~120重量份、菊花35~40重量份、杜仲55~60重量份、菟丝子55~60重量份、陈皮75~80重量份、丹皮15~20重量份、旱莲草25~30重量份、当归25~30重量份以及麦冬25~30重量份。
优选地，所述治疗更年期综合症的中药组合物的组分及重量份为：
何首乌100~105重量份、女贞子120~125重量份、苦丁茶20~25重量份、合欢皮120~125重量份、枸杞叶120~125重量份、菊花40~45重量份、杜仲60~65重量份、菟丝子60~65重量份、陈皮80~85重量份、丹皮20~25重量份、旱莲草30~35重量份、当归30~35重量份以及麦冬30~35重量份。
优选地，所述治疗更年期综合症的中药组合物的组分及重量份为：
何首乌100重量份、女贞子120重量份、苦丁茶20重量份、合欢皮120重量份、枸杞叶120重量份、菊花40重量份、杜仲60重量份、菟丝子60重量份、陈皮80重量份、丹皮20重量份、旱莲草30重量份、当归30重量份以及麦冬30重量份。
此外，为实现上述目的，本发明还提供一种上述治疗更年期综合症的中药组合物的制备方法，包括如下步骤：
将各组分研磨成粉状后装入棉袋中；
将棉袋置入常温水中浸泡，并煮沸常温水，然后再煎煮，并将药液A倒出备用；
加入常温水浸泡棉袋，并煮沸常温水，然后再煎煮，将药液B倒出备用；
再次加入常温水浸泡棉袋，并煮沸常温水，然后再煎煮，将药液C倒出备用；
将所述药液A、药液B以及药液C混合制得药液D备用。
优选地，所述治疗更年期综合症的中药组合物的制备方法还包括如下步骤：
将所述药液D置于离心机中，在3500~5000
rpm转速下离心30~60分钟，得到分为淡黄色透明层和深色层的药液E；
将药液E中深色层液体取出，密封包装备用。
优选地，所述治疗更年期综合症的中药组合物的制备方法还包括如下步骤：
将所述药液D直接放在容器中煎煮，让药液D挥发得到药液E’，所述药液E’容量为所述药液D容量的2/3；
取出药液E’，密封包装备用。
优选地，所述将棉袋置入常温水中浸泡，并煮沸常温水，然后再煎煮，并将药液A倒出备用的步骤中，所述常温水的用量为各组分总重量的7~10倍，浸泡时间为25~35分钟，所述常温水采用武火煮沸后调至文火煎煮，其中，文火煎煮时间为5~8分钟。
优选地，所述浸泡时间为30分钟，所述文火煎煮时间为5分钟。
优选地，所述加入常温水浸泡棉袋，并煮沸常温水，然后再煎煮，将药液B倒出备用的步骤中，所述常温水的用量为各组分总重量的7~10倍，所述常温水采用武火煮沸后调至文火煎煮，其中，文火煎煮时间为10~12分钟。
优选地，所述文火煎煮时间为10分钟。
优选地，所述再次加入常温水浸泡棉袋，并煮沸常温水，然后再煎煮，将药液C倒出备用的步骤中，所述常温水的用量为各组分总重量的7~10倍，所述常温水采用武火煮沸后调至文火煎煮，其中，文火煎煮时间为15~18分钟。
优选地，所述文火煎煮时间为15分钟。
本发明的治疗更年期综合症的中药组合物及其制备方法，采用普通的中药材料，其成本低；且采用该中药组合物治疗更年期综合症的有效率为91.3%，治愈率为82.6%，其治疗效果确切，达到了治愈的治疗效果。该治疗更年期综合症的中药组合物的制备方法简单、效率高、且还有利于药物有效成分的保存及提取。
具体实施方式
应当理解，此处所描述的具体实施例仅仅用以解释本发明，并不用于限定本发明。
本发明提供一种治疗更年期综合症的中药组合物，该治疗更年期综合症的中药组合物的组分及重量份为：
何首乌95~105重量份、女贞子115~125重量份、苦丁茶15~25重量份、合欢皮115~125重量份、枸杞叶115~125重量份、菊花35~45重量份、杜仲55~65重量份、菟丝子55~65重量份、陈皮75~85重量份、丹皮15~25重量份、旱莲草25~35重量份、当归25~35重量份以及麦冬25~35重量份。
其中，该治疗更年期综合症的中药组合物的各组分的方解为：
何首乌：补肝，益肾，养血，祛风。治肝肾阴亏，发须早白，血虚头晕，腰膝软弱，筋骨酸痛，遗精，崩带，久疟，久痢，慢性肝炎，痈肿，瘰疬，肠风，痔疾。
女贞子：补肝肾，强腰膝。治阴虚内热，头晕，目花，耳鸣，腰膝酸软，须发早白。滋补肝肾，明目乌发。用于眩晕耳鸣，腰膝酸软，须发早白，目暗不明。
苦丁茶：散风热，清头目，除烦渴。治头痛，齿痛，目赤，脓耳，热病烦渴，痢疾。
合欢皮：解郁，和血，宁心，消痈肿。治心神不安，忧郁失眠，肺痈，痈肿，瘰疬，筋骨折伤。
枸杞叶：补虚益精，清热，止渴，祛风明目。治虚劳发热，烦渴，目赤昏痛，障翳夜盲，崩漏带下，热毒疮肿。
菊花：平肝明目，散风清热，消咳止痛。用于治疗头痛眩晕，目赤肿痛，风热感冒，咳嗽。
杜仲：补肝肾，强筋骨，安胎。治腰脊酸疼，足膝痿弱，小便余沥，阴下湿痒，胎漏欲堕，胎动不安，高血压。
菟丝子：补肝肾，益精髓，明目。治腰膝酸痛，遗精，消渴，尿有余沥，目暗。
陈皮：理气，调中，燥湿，化痰。治胸腹胀满，不思饮食，呕吐哕逆，咳嗽痰多。亦解鱼、蟹毒。
丹皮：清热凉血、退虚热、消瘀。
旱莲草：滋补肝肾，凉血止血。
当归：补血和血，调经止痛，润燥滑肠。用于血虚，面色萎黄，眩晕心悸；血虚，或兼有瘀滞的月经不调、经闭、痛经；虚寒性腹痛、冠心病心绞痛、风湿痹痛、跌打损伤等痛证；肠燥便秘；久咳气喘。
麦冬：养阴生津，润肺清心。用于肺燥干咳。虚痨咳嗽，津伤口渴，心烦失眠，内热消渴，肠燥便秘；咽白喉。治肺燥干咳，吐血，咯血，肺痿，肺痈，虚劳烦热，消渴，热病津伤，咽干口燥，便秘。
本发明治疗更年期综合症的中药组合物的药理为：《素问·上古天真论》有说：女子二七天癸至，七七任脉虚，太冲脉衰少，天癸竭，地道不通，故形坏而无子也。妇女将届经断之年，先天肾气渐衰，任脉虚，太冲脉衰，天癸将竭，导致机体阴阳失稀，或肾阴不足，阳失潜藏；或肾阳虚衰，经脉失于温养，出现一系列脏腑功能紊乱的症候。本发明治疗更年期综合症的中药组合物的方义为：以补肝肾益精血、疏解郁热、凉血安神配伍组方。其中，女贞子、首乌、枸杞叶、杜仲、菟丝子、当归补肝肾养血；麦冬、旱莲草滋阴；苦丁、丹皮清热凉血；橘皮、菊花理气疏散，合欢皮解郁；共奏补益肝肾、凉血清热、解郁安神之效。
优选地，所述治疗更年期综合症的中药组合物的组分及重量份为：
何首乌95~100重量份、女贞子115~120重量份、苦丁茶15~20重量份、合欢皮115~120重量份、枸杞叶115~120重量份、菊花35~40重量份、杜仲55~60重量份、菟丝子55~60重量份、陈皮75~80重量份、丹皮15~20重量份、旱莲草25~30重量份、当归25~30重量份以及麦冬25~30重量份。
优选地，所述治疗更年期综合症的中药组合物的组分及重量份为：
何首乌97~102重量份、女贞子117~122重量份、苦丁茶17~22重量份、合欢皮117~122重量份、枸杞叶117~122重量份、菊花37~42重量份、杜仲57~62重量份、菟丝子57~62重量份、陈皮77~82重量份、丹皮17~22重量份、旱莲草27~32重量份、当归27~32重量份以及麦冬27~32重量份。
优选地，所述治疗更年期综合症的中药组合物的组分及重量份为：
何首乌100~105重量份、女贞子120~125重量份、苦丁茶20~25重量份、合欢皮120~125重量份、枸杞叶120~125重量份、菊花40~45重量份、杜仲60~65重量份、菟丝子60~65重量份、陈皮80~85重量份、丹皮20~25重量份、旱莲草30~35重量份、当归30~35重量份以及麦冬30~35重量份。
本发明还提供一种上述治疗更年期综合症的中药组合物的制备方法，包括如下步骤：
（1）将各组分研磨成粉状后装入棉袋中。其中，各组分通过研磨装置研磨成粉状。其中，棉袋优选为纱布袋。
（2）将棉袋置入各组分总重量的7~10倍用量的常温水中浸泡25~35分钟，并采用武火煮沸常温水，然后再调至文火煎煮5~8分钟，并将药液A倒出备用。其中，采用常用的煎熬中药的容器（砂锅或搪瓷容器）盛放常温水，棉袋放入该容器中并浸泡在常温水中，浸泡时间优选为30分钟，文火煎煮时间优选为5分钟。
（3）加入各组分总重量的7~10倍用量的常温水浸泡棉袋，并用武火煮沸常温水，然后再调至文火煎煮10~12分钟，将药液B倒出备用；其中，文火煎煮时间优选为10分钟。
（4）再加入各组分总重量的7~10倍用量的常温水浸泡棉袋，并用武火煮沸常温水，然后再调至文火煎煮15~18分钟，将药液C倒出备用；其中，文火煎煮时间优选为15分钟。
（5）将药液A、药液B和药液C混合制得药液D备用。
（6）将药液D置于离心机中，在3500~5000
rpm转速下离心30~60分钟，得到分为淡黄色透明层和深色层的药液E；将药液E中的深色层液体取出，密封包装备用。或者，将药液D直接放在容器中煎煮，让药液D挥发得到药液E’，药液E’容量为药液D容量的2/3；取出药液E’，密封包装备用。其中，上述包装方式为以500ml一份装袋，然后封口备用。
上述制备方法简单、效率高、有利于药物有效成分的保存及提取。
以下通过实施例对本发明的治疗更年期综合症的中药组合物、制备方法及其使用方法做详细说明：
实施例1
提供按克计量的中药组分：何首乌100g、女贞子120g、苦丁茶20g、合欢皮120g、枸杞叶120g、菊花40g、杜仲60g、菟丝子60g、陈皮80g、丹皮20g、旱莲草30g、当归30g以及麦冬30g，共830g;
将上述各中药组分通过研磨装置碾磨成粉末状后装入纱布袋中；
将装有粉末状中药组分的纱布袋置入盛有5.81~8.30Kg的常温水的砂锅中浸泡30分钟，常温水优选为6Kg，药材大约会吸收1600g左右的水；
先用武火将常温水煮沸，然后再调至文火煎煮5分钟后，关火并将药液A倒出备用；
向砂锅中加入5.81~8.30Kg的常温水，优选地加入6Kg的常温水，用武火将常温水煮沸，文火煎煮10分钟后，关火并将药液B倒出备用，6Kg的常温水基本不会被药物吸收；
再加入5.81~8.30Kg的常温水，优选地加入6Kg的常温水，用武火将常温水煮沸，文火煎煮15分钟后，关火并将药液C倒出备用，将药液A、药液B和药液C混合均匀得到药液D备用，约为16.4Kg；
在使用时，取适量药液D倒入浴盆中，兑入15L温度为40-50度左右的热水泡脚，浸至小腿三分之二处，每日一次，症状严重者一日二次，每次40分钟，30天为一疗程。
实施例2
在上述实施例1制备得到的16.4Kg的药液D基础上，为了便于药液的包装和封存，对药液D进行提纯浓缩：
将药液D趁热置于离心机中，在3500~5000
rpm转速下离心30~60分钟，得到分为淡黄色透明层和深色层的药液E，将药液E中的深色层液体取出，假设每次加入的常温水为6Kg，则最后得到药液E中的深色层液体约为8Kg，即8000ml，以500ml为一份装袋，共16包，然后封口备用；
在使用时，取3包500ml的药液E倒入浴盆中，兑入15L温度为40-50度左右的热水泡脚，浸至小腿三分之二处，每日一次，症状严重者一日二次，每次40分钟，30天为一疗程。
实施例3
在上述实施例1制备得到的16.4Kg的药液D基础上，为了便于药液的包装和封存，对药液D进行提纯浓缩：
将药液D直接放在容器中煎煮，让药液D挥发得到药液E’，药液E’容量为药液D容量的2/3；假设每次加入的常温水为6Kg，则最后一步通过直接煎煮的方式得到的药液E’约为16.4Kg*（2/3）=10.9Kg，约10900ml，每500ml为一份装袋，约21包，然后封口备用。
本实施例通过蒸发方法得到的药液E’比上述实施例2通过离心方法得到的药液E的深色层液体的浓度低，制备时间久，但其对药物的利用率高。
在使用时，取4包500ml的药液E’倒入浴盆中，兑入15L温度为40-50度左右的热水泡脚，浸至小腿三分之二处，每日一次，症状严重者一日二次，每次40分钟，30天为一疗程。
使用本发明的中药组合物的药液的足浴治疗方法，具有如下优点：
1、健脾益气、宁心安神和中药剂健脾补肾、益气养血的效果，通过多元化的手段使得治疗起效快；
2、利用皮肤的分泌、吸收、渗透等功能，能够使药物通过皮肤表层吸收、角质层渗透和真皮层转运，进入血液循环直达病灶，保证了药物的充分吸收，也避免了药物内服时对胃肠的损伤。
本具体实施方式的治疗更年期综合症的中药组合物的治疗效果通过下述的临床试验做进一步说明：
临床试验：
1、诊治患者46例。
2、诊断标准：
临床主要表现：
（1）烘热、出汗；（2）烦躁易怒；（3）心悸心慌；（4）月经紊乱。
3、治疗方法：
选用本具体实施方式中药组合物给患者使用，每日一次，30天为一个疗程，连续使用2个疗程。
4、疗效评定标准：
治愈：烘热汗出、烦躁易怒消失，自我感觉舒适。偶有心悸心慌，月经量少，直至绝经，观察半年后无复发。
好转：烘热汗出、烦躁易怒症状明显减轻，但伴有心悸心慌，月经紊乱。
无效：治疗后症状无变化。
5、治疗结果
在上述的治疗中，用本具体实施方式中药组合物治疗更年期综合症患者46例，一般患者治疗一疗程明显好转，连用两个疗程治愈38例，治愈率为82.6%，好转4例，好转率为8.7%，无效4例，无效率8.7%，总有效率为91.3%。
如下为从46例患者中选取的5例典型病例：
病例1：丁某，女，48岁。患者2年来月经紊乱，每15~18天行经一次，持续4~5天，量多，色红，有块，并伴头晕眼花、耳鸣、心悸、失眠、烦躁易怒、烘热出汗，曾服谷维素、维生素、安定、更年安等药物效果不明显。使用本发明中药组合物前症状为：月经周期紊乱、头晕、心悸、健忘、失眠、耳鸣、烘热出汗、烦躁易怒、善感伤，舌淡红，舌苔薄微黄，脉弦细。使用本发明中药组合物，每日1次，1个疗程后，症状明显好转，继续泡脚2个疗程，痊愈。随访1年未见复发。
病例2：尹某，女，49岁。患者1年来出现月经先后不定期，并伴有心悸失眠、神疲乏力、烦躁不安、烘热汗出、记忆力减退、纳食不香，大便干结，5~6日一行，其舌质淡红，苔薄白，脉弦细。诊断为更年期综合症。使用本发明中药组合物，每日1次，1个疗程后，症状明显好转，继续使用1个疗程，痊愈。随访6个月未见复发。
病例3：孙某某，女，47岁，老师。患者一年前因月经过多、子宫纤维腺瘤行子宫切除术，因对手术顾虑较多，故手术后出现情志异常，精神抑郁，健忘易哭，心悸怔忡，失眠，纳呆，大便溏，神疲乏力，舌质淡红，苔薄白，脉细数。使用本发明中药组合物治疗，每日1次，1个疗程后，患者睡眠好转，精神较前有所改善，继续使用2个疗程，精神饱满，情绪稳定，睡眠佳，大小便正常。随访半年未见复发。
病例4：李某，女，51岁，干部。患者近一年月经紊乱，或先或后，量时多时少，夜间汗多，烦躁不安，无法入眠，面色晦暗，形寒肢冷，神疲乏力，腰膝酸疼，纳呆便溏，面浮肢肿，舌质淡胖，有齿印，苔薄白，脉沉细。使用本发明中药组合物，每日1次，1个疗程后，患者各症状均好转，继续使用1个疗程，各症状消失。随访半年未见复发。
病例5：王某，40岁，近半年月经不规则、多汗、心悸，情绪不稳定、多疑烦躁，病人非常痛苦，使用本发明中药组合物，每日1次，用药一个疗程后，症状基本消失，用药两个疗程后症状完全消失，随访观察6个月，月经规律，情绪稳定，睡眠好，病人满意。随访半年未见复发。
以上仅为本发明的优选实施例，并非因此限制本发明的专利范围，凡是利用本发明说明书内容所作的等效结构或等效流程变换，或直接或间接运用在其他相关的技术领域，均同理包括在本发明的专利保护范围内。
Claims (15)
- 一种治疗更年期综合症的中药组合物，所述治疗更年期综合症的中药组合物的组分及重量份为：何首乌95~105重量份、女贞子115~125重量份、苦丁茶15~25重量份、合欢皮115~125重量份、枸杞叶115~125重量份、菊花35~45重量份、杜仲55~65重量份、菟丝子55~65重量份、陈皮75~85重量份、丹皮15~25重量份、旱莲草25~35重量份、当归25~35重量份以及麦冬25~35重量份。
- 如权利要求1所述的治疗更年期综合症的中药组合物，所述治疗更年期综合症的中药组合物的组分及重量份为：何首乌95~100重量份、女贞子115~120重量份、苦丁茶15~20重量份、合欢皮115~120重量份、枸杞叶115~120重量份、菊花35~40重量份、杜仲55~60重量份、菟丝子55~60重量份、陈皮75~80重量份、丹皮15~20重量份、旱莲草25~30重量份、当归25~30重量份以及麦冬25~30重量份。
- 如权利要求1所述的治疗更年期综合症的中药组合物，所述治疗更年期综合症的中药组合物的组分及重量份为：何首乌100~105重量份、女贞子120~125重量份、苦丁茶20~25重量份、合欢皮120~125重量份、枸杞叶120~125重量份、菊花40~45重量份、杜仲60~65重量份、菟丝子60~65重量份、陈皮80~85重量份、丹皮20~25重量份、旱莲草30~35重量份、当归30~35重量份以及麦冬30~35重量份。
- 如权利要求1所述的治疗更年期综合症的中药组合物，所述治疗更年期综合症的中药组合物的组分及重量份为：何首乌100重量份、女贞子120重量份、苦丁茶20重量份、合欢皮120重量份、枸杞叶120重量份、菊花40重量份、杜仲60重量份、菟丝子60重量份、陈皮80重量份、丹皮20重量份、旱莲草30重量份、当归30重量份以及麦冬30重量份。
- 一种如权利要求1所述的治疗更年期综合症的中药组合物的制备方法，包括如下步骤：将各组分研磨成粉状后装入棉袋中；将棉袋置入常温水中浸泡，并煮沸常温水，然后再煎煮，并将药液A倒出备用；加入常温水浸泡棉袋，并煮沸常温水，然后再煎煮，将药液B倒出备用；再次加入常温水浸泡棉袋，并煮沸常温水，然后再煎煮，将药液C倒出备用；将所述药液A、药液B以及药液C混合制得药液D备用。
- 如权利要求5所述的治疗更年期综合症的中药组合物的制备方法，还包括如下步骤：将所述药液D置于离心机中，在3500~5000 rpm转速下离心30~60分钟，得到分为淡黄色透明层和深色层的药液E；将药液E中深色层液体取出，密封包装备用。
- 如权利要求5所述的治疗更年期综合症的中药组合物的制备方法，还包括如下步骤：将所述药液D直接放在容器中煎煮，让药液D挥发得到药液E’，所述药液E’容量为所述药液D容量的2/3；取出药液E’，密封包装备用。
- 如权利要求5所述的治疗更年期综合症的中药组合物的制备方法，其中，所述将棉袋置入常温水中浸泡，并煮沸常温水，然后再煎煮，并将药液A倒出备用的步骤中，所述常温水的用量为各组分总重量的7~10倍，浸泡时间为25~35分钟，所述常温水采用武火煮沸后调至文火煎煮，其中，文火煎煮时间为5~8分钟。
- 如权利要求8所述的治疗更年期综合症的中药组合物的制备方法，其中，所述浸泡时间为30分钟，所述文火煎煮时间为5分钟。
- 如权利要求5所述的治疗更年期综合症的中药组合物的制备方法，其中，所述加入常温水浸泡棉袋，并煮沸常温水，然后再煎煮，将药液B倒出备用的步骤中，所述常温水的用量为各组分总重量的7~10倍，所述常温水采用武火煮沸后调至文火煎煮，其中，文火煎煮时间为10~12分钟。
- 如权利要求10所述的治疗更年期综合症的中药组合物的制备方法，其中，所述文火煎煮时间为10分钟。
- 如权利要求5所述的治疗更年期综合症的中药组合物的制备方法，其中，所述再次加入常温水浸泡棉袋，并煮沸常温水，然后再煎煮，将药液C倒出备用的步骤中，所述常温水的用量为各组分总重量的7~10倍，所述常温水采用武火煮沸后调至文火煎煮，其中，文火煎煮时间为15~18分钟。
- 如权利要求12所述的治疗更年期综合症的中药组合物的制备方法，其中，所述文火煎煮时间为15分钟。
- 一种如权利要求4所述的治疗更年期综合症的中药组合物的制备方法，包括如下步骤：将各组分研磨成粉状后装入棉袋中；将棉袋置入常温水中浸泡，并煮沸常温水，然后再煎煮，并将药液A倒出备用；加入常温水浸泡棉袋，并煮沸常温水，然后再煎煮，将药液B倒出备用；再次加入常温水浸泡棉袋，并煮沸常温水，然后再煎煮，将药液C倒出备用；将所述药液A、药液B以及药液C混合制得药液D备用。
- 如权利要求14所述的治疗更年期综合症的中药组合物的制备方法，还包括如下步骤：将所述药液D置于离心机中，在3500~5000 rpm转速下离心30~60分钟，得到分为淡黄色透明层和深色层的药液E；将药液E中深色层液体取出，密封包装备用；或者，将所述药液D直接放在容器中煎煮，让药液D挥发得到药液E’，所述药液E’容量为所述药液D容量的2/3；取出药液E’，密封包装备用。
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