WO2017016088A1 - 一种治疗过敏性哮喘的中药及其制备方法 - Google Patents

一种治疗过敏性哮喘的中药及其制备方法 Download PDF

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WO2017016088A1
WO2017016088A1 PCT/CN2015/093352 CN2015093352W WO2017016088A1 WO 2017016088 A1 WO2017016088 A1 WO 2017016088A1 CN 2015093352 W CN2015093352 W CN 2015093352W WO 2017016088 A1 WO2017016088 A1 WO 2017016088A1
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liquid
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邱程程
张平平
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济南正骐生物科技有限公司
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger

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  • the invention belongs to the field of traditional Chinese medicine preparations, and particularly relates to a traditional Chinese medicine for treating allergic asthma and a preparation method thereof.
  • Allergic asthma is a kind of trachea caused by the body's antigenic stimulation - A disease with increased bronchial reactivity. Most patients have obvious history of allergen exposure. There are many mucosal allergic signs such as nasal, itchy eyes, sneezing, runny or dry cough, followed by expiratory difficulty with wheezing and chest tightness, which lasts for several minutes. It can be relieved by itself for a few hours, but the disease lasts and it is difficult to eradicate.
  • the existing western medicines for treating allergic asthma mainly include: glucocorticoids, anti-leukotrienes, and ⁇ . - Adrenal receptor agonists, etc. These chemicals have obvious toxic side effects. The existing Chinese medicine treatment cycle is longer and the effect is not satisfactory.
  • the invention discloses a traditional Chinese medicine for treating allergic asthma and a preparation method thereof for solving the deficiency of the prior art, which is safe, effective and has good curative effect.
  • the medicine adopts pure Chinese medicine, has no side effects, has high cure rate, quick effect, is not easy to relapse, and has simple preparation method.
  • a traditional Chinese medicine for treating allergic asthma mainly in proportion to parts by weight:
  • invertebrate 30-35 parts of invertebrate, medlar, Prunella vulgaris, turmeric, and solid, 25-30 parts of Houttuynia cordata, Cassia sinensis, Sophora flavescens and Ligustrum lucidum, each of which is 15% in Astragalus, Bazaar and Yuzhu -20 parts, 10-15 parts of Guizhi, Fengfeng, Xinyi and Pinellia, 8-10 parts of almond, licorice, sage and white mustard.
  • the traditional Chinese medicine is mainly distributed in parts by weight: invertebrate, medlar, Prunella, turmeric, and solid 31, Houttuynia cordata, Cassia, Sophora flavescens, female
  • There are 27 servings of medlar 15 servings of Astragalus, Bayu Tian and Yuzhu, 13 servings of Guizhi, Fangfeng, Xinyi and Pinellia, and 8 servings of almond, licorice, sage and white mustard.
  • the specific preparation method is as follows:
  • a according to the proportion of the inversion of flowers, alfalfa, Prunella, turmeric, solid, Houttuynia, stone Cassia, Sophora, Ligustrum lucidum, Astragalus, Polygonatum, Guizhi, wind, Xinyi, Pinellia, Almond, licorice, succulent, white mustard into the casserole, add 6-7 times the weight of cold water soak for 60-90 minutes, simmer until boiling, simmer for 60-90 minutes, filter to obtain a liquid;
  • the process parameters are: soaking time 60-70 minutes; simmering time is 70-90 minutes.
  • Morinda does not need to be soaked, and the water is boiled and then boiled. This is because the active ingredients are easily leached after soaking for a long time and are easily dehydrated. Therefore, Morinda is added after the second boiling.
  • This medicine is a tablet, 2 tablets at a time, twice a day, usually a course of 6 days, and even take 4 courses.
  • the invention provides a traditional Chinese medicine for treating allergic asthma and a preparation method thereof, which can improve various symptoms caused by arrhythmia in a patient, improve the quality of life of the patient, and have no toxic and side effects, and the patient can take it with ease.
  • a traditional Chinese medicine for treating allergic asthma the main distribution ratio is: by weight:
  • the specific preparation method is as follows:
  • a according to the proportion of the inversion of flowers, alfalfa, Prunella, turmeric, solid, Houttuynia, stone Cassia, Sophora, Ligustrum lucidum, Astragalus, Polygonatum, Guizhi, wind, Xinyi, Pinellia, Almond, licorice, succulent, white mustard seeds are added to the casserole, soaked in 6 times the weight of cold water for 60 minutes, simmered to boiling, simmer for 90 minutes, and filtered to obtain a liquid medicine;
  • a traditional Chinese medicine for treating allergic asthma mainly in proportion to parts by weight:
  • inulin 30 parts of inulin, medlar, Prunella vulgaris, turmeric, and solid, 25 pieces of Houttuynia cordata, Cassia sinensis, Sophora flavescens and Ligustrum lucidum, 15 parts of Astragalus, Bazaar and Polygonatum, Guizhi 10 parts of wind, Xinyi and Pinellia, 8 parts of almond, licorice, succulent and white mustard.
  • the specific preparation method is as follows:
  • a traditional Chinese medicine for treating allergic asthma mainly in proportion to parts by weight:
  • invertebrate 35 parts of invertebrate, medlar, Prunella vulgaris, turmeric, and solid, 30 parts of Houttuynia cordata, Cassia sinensis, Sophora flavescens and Ligustrum lucidum, 20 parts of Astragalus, Bazao and Polygonatum, Guizhi 15 parts of wind, Xinyi and Pinellia, 10 parts of almond, licorice, succulent and white mustard.
  • the specific preparation method is as follows:
  • a according to the proportion of the inversion of flowers, alfalfa, Prunella, turmeric, solid, Houttuynia, stone Cassia, Sophora, Ligustrum lucidum, Astragalus, Polygonatum, Guizhi, wind, Xinyi, Pinellia, Almond, licorice, succulent, white mustard seeds are added to the casserole, soaked in 6 times the weight of cold water for 80 minutes, simmered to boiling, simmer for 70 minutes, filtered to obtain a liquid medicine a;
  • a traditional Chinese medicine for treating allergic asthma mainly in proportion to parts by weight:
  • invertebrate There are 33 parts of invertebrate, medlar, Prunella vulgaris, turmeric, and solid, 28 of Houttuynia cordata, Cassia sinensis, Sophora flavescens, and Ligustrum lucidum, 17 parts of Astragalus, Basil and Yuzhu, respectively.
  • the specific preparation method is as follows:
  • a according to the proportion of the inversion of flowers, alfalfa, Prunella, turmeric, solid, Houttuynia, stone Cassia, Sophora, Ligustrum lucidum, Astragalus, Polygonatum, Guizhi, wind, Xinyi, Pinellia, Almond, licorice, succulent, white mustard are added to the casserole, plus 6 Soak the cold water for 70 minutes, simmer until boiling, simmer for 60 minutes, filter to obtain a liquid;
  • Treatment results a total of 100 patients, 25 patients in each case, after taking a course of treatment, the symptoms have improved, after taking 4 courses of treatment, 72 people recovered, 18 people markedly effective, 6 effective, 4 invalid, total
  • the effective rate is 96%.

Abstract

一种治疗过敏性哮喘的中药及其制备方法，所述中药由下列重量份的原料制成：旋覆花30-35、蝉蜕30-35、夏枯草30-35、郁金30-35、枳实30-35、鱼腥草25-30、石决明25-30、苦参25-30、女贞子25-30、黄芩15-20、巴戟天15-20、玉竹15-20、桂枝10-15、防风10-15、辛夷10-15、半夏10-15、杏仁8-10、甘草8-10、苏子8-10、白芥子8-10。

Description

一种治疗过敏性哮喘的中药及其制备方法 一种治疗过敏性哮喘的中药及其制备方法
技术领域
本发明属于中药制剂领域，具体涉及一种治疗过敏性哮喘的中药及其制备方法。
背景技术
过敏性哮喘是机体对抗原性刺激引起的一种气管 - 支气管反应性增高的疾病。多数患者有明显的过敏原接触史，发作时多有鼻、眼脸痒，喷嚏，流涕或干咳等粘膜过敏先兆，继之出现带哮鸣音的呼气性困难、胸闷，持续数分钟至数小时可自行缓解，但此病长发作，难以根除。目前，现有的治疗过敏性哮喘的西药主要有：糖皮质激素类药物、抗白三烯药物、β - 肾上腺受体激动药等，这些化学药物具有明显的毒副作用。现有的中药治疗周期较长，效果不理想。
发明内容
本发明为解决现有技术的不足公开了一种安全有效，治愈效果好的一种治疗过敏性哮喘的中药及其制备方法。该药物采用纯中药，无副作用，治愈率高，见效快，不易复发，制备方法简单。
一种治疗过敏性哮喘的中药，主要成分配比按重量份计：
旋覆花、蝉蜕、夏枯草、郁金、积实各30-35份，鱼腥草、石决明、苦参、女贞子各25-30份，黄芩、巴戟天、玉竹各15-20份，桂枝、防风、辛夷、半夏各10-15份，杏仁、甘草、苏子、白芥子各8-10份。
作为上述技术方案的进一步优选，所述中药主要成分配比按重量份计：旋覆花、蝉蜕、夏枯草、郁金、积实各31份，鱼腥草、石决明、苦参、女贞子各27份，黄芩、巴戟天、玉竹各15份，桂枝、防风、辛夷、半夏各13份，杏仁、甘草、苏子、白芥子各8份。
根据以上工艺处方，具体制备方法如下：
a、按比例将旋覆花、蝉蜕、夏枯草、郁金、积实、鱼腥草、石决明、苦参、女贞子、黄芩、玉竹、桂枝、防风、辛夷、半夏、杏仁、甘草、苏子、白芥子加入砂锅中，加6-7倍重量的冷水浸泡60-90分钟，武火煎至沸腾，文火煎煮60-90分钟，过滤得药液a；
b、向砂锅加入3-5倍重量的水进行第二次煎煮，武火煎至沸腾后，按比例将巴戟天加入沸腾的药液中，文火煎煮60-90分钟，过滤得药液b；
c、将药液a和b混合均匀，过滤得清液c；
d、向清液c中加3倍体积量的质量分数为75%的酒精，搅拌均匀，沉淀过夜，取上清液浓缩得浸膏，按照常规工艺制成口服片剂。
进一步优化上述制备方法，工艺参数为：浸泡时间60-70分钟；文火煎制时间均为70-90分钟。
巴戟天不需浸泡，直接水沸腾之后文火煎煮，这是因为其有效成分经长时间浸泡容易浸出而煎煮容易损失，因此巴戟天在第二次煎煮沸腾后文火时加入。
使用方法：本药剂为片剂，一次2片，一天两次，一般6天一个疗程，连服4个疗程。
药理分析：
旋覆花降气化痰平喘，抗过敏，抗组胺引起的支气管痉挛性哮喘；蝉蜕、桂枝、防风、辛夷抗过敏，解表宣肺，有更好地宣降，解除哮喘状态；配积实、郁金能抗过敏，降气理气，能使肺气更好的宣降，解除哮喘状态；夏枯草、鱼腥草、黄芩清肝肺之火，抗炎抗过敏，有利于解除哮喘状态；石决明能抑菌，镇静，抗缺氧，扩张支气管平滑肌，抑制免疫而抗过敏；苦参能抗过敏、抗炎祛痰平喘；女贞子补肾以助纳气平喘，强心利尿，抗炎抗过敏；巴戟天、玉竹促进肾上腺皮质功能，增强止哮喘作用；半夏具有燥湿化痰，降逆止呕的作用；杏仁、甘草、苏子具有止咳平喘，解毒祛痰止痛的作用；白芥子有利气消痰，散肿止痛，治喘咳。上述药物配伍使用，协同作用，从而达到治疗过敏性哮喘的目的。
本发明提供一种治疗过敏性哮喘的中药及其制备方法，能改善患者由心律失常引起的各种症状，提高了病人的生活质量，而且其无毒副作用，病人可安心服用。
具体实施方式
实施例 1
一种治疗过敏性哮喘的中药，主要成分配比按重量份计为：
旋覆花、蝉蜕、夏枯草、郁金、积实各31份，鱼腥草、石决明、苦参、女贞子各27份，黄芩、巴戟天、玉竹各15份，桂枝、防风、辛夷、半夏各13份，杏仁、甘草、苏子、白芥子各8份。
根据以上工艺处方，具体制备方法如下：
a、按比例将旋覆花、蝉蜕、夏枯草、郁金、积实、鱼腥草、石决明、苦参、女贞子、黄芩、玉竹、桂枝、防风、辛夷、半夏、杏仁、甘草、苏子、白芥子加入砂锅中，加6倍重量的冷水浸泡60分钟，武火煎至沸腾，文火煎煮90分钟，过滤得药液a；
b、向砂锅加入3倍重量的水进行第二次煎煮，武火煎至沸腾后，按比例将巴戟天加入沸腾的药液中，文火煎煮60分钟，过滤得药液b；
c、将药液a和b混合均匀，过滤得清液c；
d、向清液c中加3倍体积量的质量分数为75%的酒精，搅拌均匀，沉淀过夜，取上清液浓缩得浸膏，按照常规工艺制成口服片剂。
实施例 2
一种治疗过敏性哮喘的中药，主要成分配比按重量份计：
旋覆花、蝉蜕、夏枯草、郁金、积实各30份，鱼腥草、石决明、苦参、女贞子各25份，黄芩、巴戟天、玉竹各15份，桂枝、防风、辛夷、半夏各10份，杏仁、甘草、苏子、白芥子各8份。
根据以上工艺处方，具体制备方法如下：
a、按比例将旋覆花、蝉蜕、夏枯草、郁金、积实、鱼腥草、石决明、苦参、女贞子、黄芩、玉竹、桂枝、防风、辛夷、半夏、杏仁、甘草、苏子、白芥子加入砂锅中，加7倍重量的冷水浸泡90分钟，武火煎至沸腾，文火煎煮60分钟，过滤得药液a；
b、向砂锅加入5倍重量的水进行第二次煎煮，武火煎至沸腾后，按比例将巴戟天加入沸腾的药液中，文火煎煮90分钟，过滤得药液b；
c、将药液a和b混合均匀，过滤得清液c；
d、向清液c中加3倍体积量的质量分数为75%的酒精，搅拌均匀，沉淀过夜，取上清液浓缩得浸膏，按照常规工艺制成口服片剂。
实施例 3
一种治疗过敏性哮喘的中药，主要成分配比按重量份计：
旋覆花、蝉蜕、夏枯草、郁金、积实各35份，鱼腥草、石决明、苦参、女贞子各30份，黄芩、巴戟天、玉竹各20份，桂枝、防风、辛夷、半夏各15份，杏仁、甘草、苏子、白芥子各10份。
根据以上工艺处方，具体制备方法如下：
a、按比例将旋覆花、蝉蜕、夏枯草、郁金、积实、鱼腥草、石决明、苦参、女贞子、黄芩、玉竹、桂枝、防风、辛夷、半夏、杏仁、甘草、苏子、白芥子加入砂锅中，加6倍重量的冷水浸泡80分钟，武火煎至沸腾，文火煎煮70分钟，过滤得药液a；
b、向砂锅加入3倍重量的水进行第二次煎煮，武火煎至沸腾后，按比例将巴戟天加入沸腾的药液中，文火煎煮60分钟，过滤得药液b；
c、将药液a和b混合均匀，过滤得清液c；
d、向清液c中加3倍体积量的质量分数为75%的酒精，搅拌均匀，沉淀过夜，取上清液浓缩得浸膏，按照常规工艺制成口服片剂。
实施例 4
一种治疗过敏性哮喘的中药，主要成分配比按重量份计：
旋覆花、蝉蜕、夏枯草、郁金、积实各33份，鱼腥草、石决明、苦参、女贞子各28份，黄芩、巴戟天、玉竹各17份，桂枝、防风、辛夷、半夏各14份，杏仁、甘草、苏子、白芥子各9份。
根据以上工艺处方，具体制备方法如下：
a、按比例将旋覆花、蝉蜕、夏枯草、郁金、积实、鱼腥草、石决明、苦参、女贞子、黄芩、玉竹、桂枝、防风、辛夷、半夏、杏仁、甘草、苏子、白芥子加入砂锅中，加 6 倍重量的冷水浸泡 70 分钟，武火煎至沸腾，文火煎煮 60 分钟，过滤得药液 a ；
b、向砂锅加入4倍重量的水进行第二次煎煮，武火煎至沸腾后，按比例将巴戟天加入沸腾的药液中，文火煎煮70分钟，过滤得药液b；
c、将药液a和b混合均匀，过滤得清液c；
d、向清液c中加3倍体积量的质量分数为75%的酒精，搅拌均匀，沉淀过夜，取上清液浓缩得浸膏，按照常规工艺制成口服片剂。
本发明临床观察的结果如下：
　　痊愈：临床症状和体征完全消失或基本消失；
显效：临床症状和体征大部分好转或明显好转；
无效；临床症状和体征均无明显改善，症状如前，效果不明显。
治疗结果：共100例患者，每实施例各25人服用，服药一个疗程后，症状均有所好转，服药4个疗程后，72人痊愈，18人显效，6人有效，4人无效，总有效率为96％。

Claims (4)

1. 一种治疗过敏性哮喘的中药，其特征是：主要成分配比按重量份计为：
旋覆花、蝉蜕、夏枯草、郁金、积实各30-35份，鱼腥草、石决明、苦参、女贞子各25-30份，黄芩、巴戟天、玉竹各15-20份，桂枝、防风、辛夷、半夏各10-15份，杏仁、甘草、苏子、白芥子各8-10份；
其制备方法具体步骤如下：
a、按比例将旋覆花、蝉蜕、夏枯草、郁金、积实、鱼腥草、石决明、苦参、女贞子、黄芩、玉竹、桂枝、防风、辛夷、半夏、杏仁、甘草、苏子、白芥子加入砂锅中，加6-7倍重量的冷水浸泡60-90分钟，武火煎至沸腾，文火煎煮60-90分钟，过滤得药液a；
b、向砂锅加入3-5倍重量的水进行第二次煎煮，武火煎至沸腾后，按比例将巴戟天加入沸腾的药液中，文火煎煮60-90分钟，过滤得药液b；
c、将药液a和b混合均匀，过滤得清液c；
d、向清液c 中加3倍体积量的质量分数为75%的酒精，搅拌均匀，沉淀过夜，取上清液浓缩得浸膏，按照常规工艺制成口服片剂。
2. 根据权利要求 1 所述的一种治疗过敏性哮喘的中药，其特征是：主要成分配比按重量份计为：旋覆花、蝉蜕、夏枯草、郁金、积实各31份，鱼腥草、石决明、苦参、女贞子各27份，黄芩、巴戟天、玉竹各15份，桂枝、防风、辛夷、半夏各13份，杏仁、甘草、苏子、白芥子各8份。
3. 一种治疗过敏性哮喘的中药的制备方法，其特征是：具体步骤为：
a、按比例将旋覆花、蝉蜕、夏枯草、郁金、积实、鱼腥草、石决明、苦参、女贞子、黄芩、玉竹、桂枝、防风、辛夷、半夏、杏仁、甘草、苏子、白芥子加入砂锅中，加6-7倍重量的冷水浸泡60-90分钟，武火煎至沸腾，文火煎煮60-90分钟，过滤得药液a；
b、向砂锅加入3-5倍重量的水进行第二次煎煮，武火煎至沸腾后，按比例将巴戟天加入沸腾的药液中，文火煎煮60-90分钟，过滤得药液b；
c、将药液a和b混合均匀，过滤得清液c；
d、向清液c中加3倍体积量的质量分数为75%的酒精，搅拌均匀，沉淀过夜，取上清液浓缩得浸膏，按照常规工艺制成口服片剂。
4. 根据权利要求 3 所述的一种治疗过敏性哮喘的中药的制备方法，其特征是：浸泡时间60-70分钟；两次文火煎制时间均为70-90分钟。
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Publication number Priority date Publication date Assignee Title
CN102100856A (zh) * 2009-12-17 2011-06-22 苏州知微堂生物科技有限公司 一种治疗支气管哮喘纳米中药及制备技术
CN102552773A (zh) * 2012-02-06 2012-07-11 孟庆云 一套治疗7-15岁儿童支气管炎、支气管哮喘的药物

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102100856A (zh) * 2009-12-17 2011-06-22 苏州知微堂生物科技有限公司 一种治疗支气管哮喘纳米中药及制备技术
CN102552773A (zh) * 2012-02-06 2012-07-11 孟庆云 一套治疗7-15岁儿童支气管炎、支气管哮喘的药物

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