CN108498690A - 一种治疗慢性鼻炎的中药组合物及其制备方法 - Google Patents

一种治疗慢性鼻炎的中药组合物及其制备方法 Download PDF

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CN108498690A
CN108498690A CN201810662532.XA CN201810662532A CN108498690A CN 108498690 A CN108498690 A CN 108498690A CN 201810662532 A CN201810662532 A CN 201810662532A CN 108498690 A CN108498690 A CN 108498690A
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宋运杰
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Lixin County Yun Jie Family Farm
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Abstract

本发明公开了一种治疗慢性鼻炎的中药组合物及其制备方法，涉及治疗慢性鼻炎的中药组合物技术领域，该中药组合物包括如下原料药：黄芩，桔梗，桃仁，红花，金银花，蒲公英，地丁，柴胡，防风，白芷，当归尾，赤芍，川芎，制乳香，制没药，贝母，天花粉，陈皮，穿山甲，皂角刺，甘草二十一味中药；并针对不同的药材属性采用不同的制备方法，不仅具有极大限度的保留药性，提高疗效，而且具有降低制备成本的作用，本发明所述药物既具有宣肺通窍、活血通络的作用，又有清热解毒、消肿止痛的功效，各种药材成分相辅相成，配方合理，药性缓和，临床疗效好。

Description

一种治疗慢性鼻炎的中药组合物及其制备方法
技术领域
本发明属于中药制剂技术领域，具体涉及一种治疗慢性鼻炎的中药组合物及其制备方法。
背景技术
慢性鼻炎是临床的常见病、多发病，是指鼻黏膜及黏膜下层的慢性炎症，其主要特点是反复发作，迁延不愈，间歇期亦不能恢复正常，且无明确的致病微生物，并伴有不同程度的鼻塞，分泌物增多，鼻黏膜肿胀或增厚等障碍，目前临床尚无特效药物治疗。依据中医理论慢性鼻炎属中医鼻窒范畴，因而创制中药制剂来治疗慢性鼻炎的报道也很多，如中国专利公开号CN104666952A公开的由川羌、天麻、远志、鸡血藤、细辛、蝉蜕、虎杖、苍耳子八味中药材组方而成，经乙醇提取浓缩后制成治疗慢性鼻炎的中药组合物。但是这些中药组合物中治疗中，往往在通窍作用上功效不强，因而影响了在治疗慢性鼻炎的临床总体疗效。
发明内容
根据以上现有技术的不足，本发明所要解决的技术问题是提出一种配方合理，辨证通窍，根据疾病不同症状，予以解毒、化痰、益气、化瘀治疗慢性鼻炎的中药组合物及其制备方法，为了解决上述技术问题，本发明采用的技术方案为：
一种治疗慢性鼻炎的中药组合物，所述中药组合物包括如下中药材：黄芩，桔梗，桃仁，红花，金银花，蒲公英，地丁，柴胡，防风，白芷，当归尾，赤芍，川芎，制乳香，制没药，贝母，天花粉，陈皮，穿山甲，皂角刺，甘草。
优选的，所述中药组合物包括如下质量百分比的中药材：黄芩5.25-6.45％，桔梗3.50-4.30％，桃仁1.75-2.15％，红花1.75-2.15％，金银花8.75-10.75％，蒲公英17.53-21.45％，地丁8.75-10.75％，柴胡1.75-2.15％，防风1.75-2.15％、白芷8.75-10.75％、当归尾2.65-3.20％、赤芍2.65-3.20％、川芎1.75-2.15％，制乳香1.05-1.30％、制没药1.05-1.30％、贝母1.75-2.15％、天花粉8.75-10.75％、陈皮1.75-2.15％、穿山甲1.75-2.15％、皂角刺5.25-6.45％，甘草1.75-2.15％。
优选的，所述中药组合物包括如下重量份中药材：黄芩30g，桔梗20g，桃仁10g，红花10g，金银花50g，蒲公英100g，地丁50g，柴胡10g，防风10g、白芷50g、当归尾15g、赤芍15g、川芎10g，制乳香6g、制没药6g、贝母10g、天花粉50g、陈皮10g、穿山甲10g、皂角刺30g，甘草10g。
治疗慢性鼻炎的中药组合物的制备方法，制备步骤如下：
1)取处方量的上述中药材，进行真空干燥2-3小时后，分别粉碎过20目筛，混合后得粗粉，按照粗粉总重量的5倍加入去离子水，热回流循环提取2-3小时后，趁热过滤，置真空减压浓缩罐中，浓缩至原总体积的10％，得流浸膏。
2)取上述所得流浸膏，加入冰糖和蜂蜜混合均匀，加热挥发总重量10％的水分，得治疗慢性鼻炎的中药组合物的糖浆剂。
优选的，所述真空干燥箱的干燥温度为40-50℃，真空度≦0.09Mpa。
优选的，所述真空减压浓缩罐夹层蒸气压力≦0.3Mpa，真空度≦0.09Mpa。
优选的，所述流浸膏与冰糖重量比为2.5:1。
优选的，所述流浸膏与蜂蜜重量比为2.5:2。
优选的，所述糖浆剂在80-85℃下，相对密度>1.24。
与现有技术相比，本发明的有益效果：
1.本发明以黄芩，桔梗，桃仁，红花，金银花，蒲公英，地丁，柴胡，防风，白芷，当归尾，赤芍，川芎，制乳香，制没药，贝母，天花粉，陈皮，穿山甲，皂角刺，甘草二十一味中药材进行组方配制。白芷、防风、柴胡既具有祛风的功效，又有通利鼻窍的功效，川穹、红花具有活血通络的功效，黄芩、甘草具有清热解毒、宣肺通窍、消肿止痛的功效，组方采用辨证通窍法，根据疾病不同症状，予以解毒、化痰、益气、化瘀治疗，临床治疗慢性鼻炎取得理想的效果。
2.本发明制备的中药药剂，制备方法简单，且选材均为较常见的中药材，具有制造成本低，并针对药材属性采用真空减压浓缩制备方法，既避免了高温对有效成分的分解破坏，又缩短了浓缩时间，降低了制备成本。
具体实施方式
下面通过对实施例的描述，作进一步详细的说明，以帮助本领域技术人员对本发明的发明构思、技术方案有更完整、准确和深入的理解。
实施例1
本实施例中治疗慢性鼻炎的中药组合物包括如下中药材：黄芩30g，桔梗20g，桃仁10g，红花10g，金银花50g，蒲公英100g，地丁50g，柴胡10g，防风10g、白芷50g、当归尾15g、赤芍15g、川芎10g，制乳香6g、制没药6g、贝母10g、天花粉50g、陈皮10g、穿山甲10g、皂角刺30g，甘草10g。
治疗慢性鼻炎的中药组合物的制备方法，制备步骤如下：
1)取处方量的上述中药材，置于温度40℃下进行真空干燥2小时后，分别用粉粹机粉碎过20目筛，混合后得粗粉，按照粗粉总重量的5倍加入去离子水，热回流循环提取3小时后，趁热过滤，置真空减压浓缩罐中，在蒸气压力0.3Mpa，真空度0.09Mpa的条件下，浓缩至原总体积的10％，得流浸膏。
2)取上述所得流浸膏，加入冰糖，并保持流浸膏与冰糖重量比为2.5:1；加入蜂蜜，并保持流浸膏与蜂蜜重量比为2.5:2，三者混合均匀，加热挥发总重量10％的水分，得治疗慢性鼻炎的中药组合物的糖浆剂，该糖浆剂在80℃下，相对密度为1.24。
实施例2
本实施例同实施例1，不同的是本实施例中治疗慢性鼻炎的中药组合物包括如下重量百分比的中药材：黄芩6.25％，桔梗4.25％，桃仁2.05％，红花2.05％，金银花9.75％，蒲公英20.53％，地丁9.75％，柴胡1.75％，防风1.75％、白芷9.75％、当归尾2.65％、赤芍2.65％、川芎1.75％，制乳香1.05％、制没药1.05％、贝母1.75％、天花粉9.75％、陈皮1.75％、穿山甲1.75％、皂角刺6.22％，甘草1.75％。
实施例3
本实施例同实施例1，不同的是本实施例中治疗慢性鼻炎的中药组合物包括如下重量百分比的中药材：黄芩5.45％，桔梗4.30％，桃仁2.15％，红花2.15％，金银花9.75％，蒲公英20.45％，地丁8.75％，柴胡2.15％，防风2.15％、白芷8.75％、当归尾3.20％、赤芍3.20％、川芎2.15％，制乳香1.30％、制没药1.30％、贝母2.15％、天花粉8.75％、陈皮2.15％、穿山甲2.15％、皂角刺5.45％，甘草2.15％。
病例疗效分析：
1.试验对象
选取80例慢性鼻炎患者，均为经多种方法治疗效果不佳的病人，将其分为两组，其中观察组为3组，对照组为1组，每组各20例，观察组的平均每组的男11例，女9例；平均年龄为(28.2士2.3)岁，病程最长12年，最短的8个月，患者均无药物过敏史，两组患者的性别、年龄和病程比较，差异无统计学意义(P＞0.05)，有可比性。
2.治疗方法
观察组：分别给予实施例1-3制备的治疗慢性鼻炎的中药组合物糖浆剂，每日3次，每次20mL，15天为1个疗程。对照组：给予呋麻液滴鼻，每日3次，口服特非那丁(60mg)，每天2次，每次1片，15天为1个疗程。
3.疗效标准
疗效判断标准，按显效、有效、无效三个标准判断疗效，其中：显效：鼻腔分泌物明显减少或消失，鼻腔通气明显改善，其他症状全部消失，鼻腔检查鼻甲下前后端黏膜无水肿，无肥大，颜色恢复正常。有效：鼻腔分泌物减少，鼻腔通气改善，鼻镜检查鼻道有少量分泌物，鼻甲无肿大。无效：治疗前后症状及鼻腔镜检查所见均无变化，或症状改善后，在1年内复发。总有效率＝显效率+有效率。
3.结果统计
数据均采用SPSS 22.0软件进行处理。计量资料以“”表示，采用t检验，计数资料以例数(n)，百分数(％)表示，采用x2检验，以P＜0.05为差异有统计学意义。
两组患者治疗效果如下：
测试结果 显效/人 有效/人 无效/人 总有效率/％
实施例1 8 10 2 90
实施例2 9 10 1 95
实施例3 7 10 3 85
对照组 5 7 8 60
两组有效率比较P＜0.05，差异有显著性。
上面结合具体实施例对本发明进行了示例性描述，显然本发明具体实现并不受上述方式的限制，只要采用了本发明的方法构思和技术方案进行的各种非实质性的改进，或未经改进将本发明的构思和技术方案直接应用于其它场合的，均在本发明的保护范围之内。本发明的保护范围应该以权利要求书所限定的保护范围为准。经研究统计两组间数据差异有统计学意义(P＜0.05)。

Claims (9)

1.一种治疗慢性鼻炎的中药组合物，其特征在于，所述中药组合物包括如下中药材：黄芩，桔梗，桃仁，红花，金银花，蒲公英，地丁，柴胡，防风，白芷，当归尾，赤芍，川芎，制乳香，制没药，贝母，天花粉，陈皮，穿山甲，皂角刺，甘草。
2.根据权利要求1所述的中药组合物，其特征在于，所述中药组合物包括如下质量百分比的中药材：黄芩5.25-6.45％，桔梗3.50-4.30％，桃仁1.75-2.15％，红花1.75-2.15％，金银花8.75-10.75％，蒲公英17.53-21.45％，地丁8.75-10.75％，柴胡1.75-2.15％，防风1.75-2.15％、白芷8.75-10.75％、当归尾2.65-3.20％、赤芍2.65-3.20％、川芎1.75-2.15％，制乳香1.05-1.30％、制没药1.05-1.30％、贝母1.75-2.15％、天花粉8.75-10.75％、陈皮1.75-2.15％、穿山甲1.75-2.15％、皂角刺5.25-6.45％，甘草1.75-2.15％。
3.根据权利要求1所述的中药组合物，其特征在于，所述中药组合物包括如下重量份中药材：黄芩30g，桔梗20g，桃仁10g，红花10g，金银花50g，公英100g，地丁50g，柴胡10g，防风10g、白芷50g、当归尾15g、赤芍15g、川芎10g，制乳香6g、制没药6g、贝母10g、天花粉50g、陈皮10g、穿山甲10g、皂角刺30g，甘草10g。
4.一种权利要求1-3任一所述的中药组合物的制备方法，其特征在于，制备步骤如下：
1)取处方量上述中药材，分别在真空干燥箱中干燥2-3小时后，用粉粹机粉粹，并通过20目筛，混合后得粗粉，按照粗粉总重量的5倍加入去离子水，热回流循环提取2-3小时后，趁热过滤，置真空减压浓缩罐中，浓缩至原总体积的10％，得流浸膏。
2)取上述所得流浸膏，加入冰糖和蜂蜜混合均匀，加热挥发总重量10％的水分，得治疗慢性鼻炎的中药组合物的糖浆剂。
5.如权利要求4所述的中药组合物的制备方法，其特征在于，所述真空干燥箱的干燥温度为40-50℃，真空度≦0.09Mpa。
6.如权利要求4所述的中药组合物的制备方法，其特征在于，所述真空减压浓缩罐的夹层蒸气压力≦0.3Mpa，真空度≦0.09Mpa。
7.如权利要求4所述的中药组合物的制备方法，其特征在于，所述流浸膏与冰糖重量比为2.5:1。
8.如权利要求4所述的中药组合物的制备方法，其特征在于，所述流浸膏与蜂蜜重量比为2.5:2。
9.如权利要求4所述的中药组合物的制备方法，其特征在于，所述糖浆剂在80-85℃下，相对密度>1.24。
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