WO2017031690A1 - 一种治疗肺炎的中药及其制备方法 - Google Patents

一种治疗肺炎的中药及其制备方法 Download PDF

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WO2017031690A1
WO2017031690A1 PCT/CN2015/088030 CN2015088030W WO2017031690A1 WO 2017031690 A1 WO2017031690 A1 WO 2017031690A1 CN 2015088030 W CN2015088030 W CN 2015088030W WO 2017031690 A1 WO2017031690 A1 WO 2017031690A1
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张平平
仝东凤
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济南正骐生物科技有限公司
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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  • the invention belongs to the field of traditional Chinese medicine preparations, and particularly relates to a traditional Chinese medicine for treating pneumonia and a preparation method thereof.
  • Pneumonia refers to inflammation of the terminal airways, alveoli, and interstitial lungs. It can be caused by pathogenic microorganisms such as bacteria, viruses, fungi, parasites, and physical and chemical factors such as radiation and inhalation foreign bodies.
  • the main clinical symptoms are fever, cough, cough, blood in the sputum, chest pain or difficulty breathing.
  • Traditional western medicine for treating pneumonia is mainly based on broad-spectrum antibiotics and comprehensive symptomatic treatment. It has certain curative effect, but the relief of some symptoms is still not ideal, and long-term side effects are large. There are also many traditional Chinese medicines for pneumonia, but the treatment period is longer and the effect is not satisfactory.
  • the invention discloses a traditional Chinese medicine for treating pneumonia and a preparation method thereof, which is safe, effective and has good curative effect, in order to solve the deficiencies of the prior art.
  • the medicine adopts pure Chinese medicine, has no side effects, has high cure rate, quick effect, is not easy to relapse, and has simple preparation method.
  • a traditional Chinese medicine for treating pneumonia mainly distributed according to the weight: heavy building, dandelion, succulent grass 30-38 Ingredients: Houttuynia cordata, winter melon kernel, fried coix seed, reed root 23-30 parts, fritillary and saponin each 15-22 parts, mulberry white and scutellaria each 10-15 parts, raw licorice 5-8 parts , antelope horn powder 1-3 Share.
  • the traditional Chinese medicine is mainly distributed in parts by weight: heavy building, dandelion, and succulent grass 30-35 Ingredients: 25-30 parts of Houttuynia cordata, winter melon kernel, fried coix seed, reed rhizome, 15-20 parts of Fritillaria and saponin, 10-15 parts of mulberry white and scutellaria, 5-8 parts of raw licorice , antelope horn powder 1-3 Share.
  • the traditional Chinese medicine is mainly distributed according to the weight ratio: heavy building, dandelion, and succulent grass 32 Ingredients: Houttuynia cordata, winter melon kernel, fried coix seed, and reed rhizome each, 26 parts, Fritillaria and saponin, 17 parts, mulberry white and yellow scorpion, 12 parts, raw licorice, and antelope horn powder.
  • the specific preparation method is as follows:
  • the process parameters are: soaking time 60-70 minutes; simmering time is 70-90 Minutes.
  • This medicine is a tablet, 2 tablets at a time, twice a day, for 10 days.
  • the invention provides a traditional Chinese medicine for treating pneumonia and a preparation method thereof, and has the functions of evacuating wind and heat, clearing the lungs and relieving the symptoms, detoxifying and removing phlegm, and improving the quality of life of patients with pneumonia, especially pediatric pneumonia, and The side effects can be taken safely by the patient.
  • a traditional Chinese medicine for treating pneumonia the main distribution ratio is: by weight:
  • the specific preparation method is as follows:
  • a according to the proportion of heavy building, dandelion, succulent grass, houttuynia, winter melon kernel, fried coix seed, reed rhizome, Fritillaria, saponin, mulberry white, sassafras, raw licorice into the casserole, add 6 times weight Cold water soak 60 Minutes, Wuhuo fry until boiling, simmer for 60 minutes, filter to obtain a liquid;
  • a traditional Chinese medicine for treating pneumonia mainly in proportion to parts by weight:
  • the specific preparation method is as follows:
  • a according to the proportion of heavy building, dandelion, succulent grass, houttuynia, winter melon kernel, fried coix seed, reed rhizome, Fritillaria, saponin, mulberry white, scutellaria, raw licorice into the casserole, add 7 times the weight Cold water soak 90 Minutes, simmer until boiling, simmer for 90 minutes, filter to obtain a liquid;
  • a traditional Chinese medicine for treating pneumonia mainly in proportion to parts by weight:
  • the specific preparation method is as follows:
  • a according to the proportion of heavy building, dandelion, succulent grass, houttuynia, winter melon kernel, fried coix seed, reed rhizome, Fritillaria, saponin, mulberry white, sassafras, raw licorice into the casserole, add 6 times weight Cold water soak 70 Minutes, Wuhuo fry until boiling, simmer for 70 minutes, filter to obtain a liquid;
  • a traditional Chinese medicine for treating pneumonia mainly in proportion to parts by weight:
  • the specific preparation method is as follows:
  • a according to the proportion of heavy building, dandelion, succulent grass, houttuynia, winter melon kernel, fried coix seed, reed rhizome, Fritillaria, saponin, mulberry white, sassafras, raw licorice into the casserole, add 6 times weight Cold water soak 80 Minutes, Wuhuo fry until boiling, simmer for 60 minutes, filter to obtain a liquid;
  • Treatment results A total of 100 patients, each taking 25 patients, after taking a course of treatment, the symptoms have improved, taking medicine 10 After the day, 72 people recovered, 18 were effective, 7 were effective, 3 were invalid, and the total effective rate was 97%.

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Abstract

一种治疗肺炎的中药,所述中药是由下列重量份的原料制成的:重楼30-38、蒲公英30-38、败酱草30-38、鱼腥草23-30、冬瓜仁23-30、炒薏苡仁23-30、芦根23-30、贝母15-22、皂角刺15-22、桑白皮10-15、黄芩10-15、生甘草5-8、羚羊角粉1-3。

Description

一种治疗肺炎的中药及其制备方法 一种治疗肺炎的中药及其制备方法
技术领域
本发明属于中药制剂领域,具体涉及一种治疗肺炎的中药及其制备方法。
背景技术
肺炎是指终末气道、肺泡和肺间质的炎症。可由细菌、病毒、真菌、寄生虫等致病微生物,以及放射线、吸入性异物等理化因素引起。临床主要症状为发热、咳嗽、咳痰、痰中带血,可伴胸痛或呼吸困难等。治疗肺炎传统西药以广谱抗生素及综合对症治疗为主,对其有一定疗效,但对部分症状的缓解仍不够理想,长期服用副作用大。也有许多针对肺炎的中药,但治疗周期较长,效果不理想。
发明内容
本发明为解决现有技术的不足公开了一种安全有效,治愈效果好的一种治疗肺炎的中药及其制备方法。该药物采用纯中药,无副作用,治愈率高,见效快,不易复发,制备方法简单。
一种治疗肺炎的中药,主要成分配比按重量份计:重楼、蒲公英、败酱草各 30-38 份,鱼腥草、冬瓜仁、炒薏苡仁、芦根各 23-30 份,贝母、皂角刺各 15-22 份,桑白皮、黄芩各 10-15 份,生甘草 5-8 份,羚羊角粉 1-3 份。
作为上述技术方案的进一步优选,所述中药主要成分配比按重量份计:重楼、蒲公英、败酱草各 30-35 份,鱼腥草、冬瓜仁、炒薏苡仁、芦根各 25-30 份,贝母、皂角刺各 15-20 份,桑白皮、黄芩各 10-15 份,生甘草 5-8 份,羚羊角粉 1-3 份。
进一步优化上述技术方案,所述中药主要成分配最佳比按重量份计:重楼、蒲公英、败酱草各 32 份,鱼腥草、冬瓜仁、炒薏苡仁、芦根各 26 份,贝母、皂角刺各 17 份,桑白皮、黄芩各 12 份,生甘草 6 份,羚羊角粉 2 份。
根据以上工艺处方,具体制备方法如下:
a 、按比例将重楼、蒲公英、败酱草、鱼腥草、冬瓜仁、炒薏苡仁、芦根、贝母、皂角刺,桑白皮、黄芩、生甘草加入砂锅中,加 6-7 倍重量的冷水浸泡 60-90 分钟,武火煎至沸腾,文火煎煮 60-90 分钟,过滤得药液 a ;
b 、向砂锅加入 3-5 倍重量的水进行第二次煎煮,武火煎至沸腾后,按比例将羚羊角粉加入沸腾的药液中,文火煎煮 60-90 分钟,过滤得药液 b ;
c 、将药液 a 和 b 混合均匀,过滤得清液 c;
d 、向清液 c 中加 3 倍体积量的质量分数为 75% 的酒精,搅拌均匀,沉淀过夜,取上清液浓缩得浸膏,按常规工艺制备口服片剂。
进一步优化上述制备方法,工艺参数为:浸泡时间 60-70 分钟;文火煎制时间均为 70-90 分钟。
使用方法:本药剂为片剂,一次 2 片,一天两次,连服 10 天。
药理分析:
重楼,苦,微寒,具有清热解毒,消肿止痛,凉肝定惊的功效;蒲公英清热解毒,利湿,可用于热毒症,治疗肝炎;败酱草清热解毒,排脓破瘀;鱼腥草味辛,性寒凉,对流感杆菌、肺炎球菌有明显的抑制作用;冬瓜仁治痰热咳嗽,肺痛,肠痈;炒薏苡仁可以治泄泻,湿痹,脉搏拘挛,屈伸不利,水肿,肺痿,肺痈,肠痈;芦根味甘,性寒,用于肺热咳嗽,肺痈吐脓;贝母养阴润肺、化痰止咳,适合久咳阴虚肺燥者;皂角刺具有消肿排脓的作用;桑白皮主治肺热,水肿,咳嗽;黄芩主治温热病,肺热咳嗽、上呼吸道感染;生甘草具有缓解止痛,清热解毒的作用;羚羊角粉具有平肝熄风,散热解毒,清肝明目的作用。上述药物配伍使用,协同作用,从而达到治疗肺炎的目的。
本发明提供一种治疗肺炎的中药及其制备方法,具有很好的疏散风热、清肺解表、解毒化痰的作用,对肺炎特别是小儿肺炎有提高了病人的生活质量,而且其无毒副作用,病人可安心服用。
具体实施方式
实施例 1
一种治疗肺炎的中药,主要成分配比按重量份计为:
重楼、蒲公英、败酱草各 32 份,鱼腥草、冬瓜仁、炒薏苡仁、芦根各 26 份,贝母、皂角刺各 17 份,桑白皮、黄芩各 12 份,生甘草 6 份;羚羊角粉 2 份。
根据以上工艺处方,具体制备方法如下:
a 、按比例将重楼、蒲公英、败酱草、鱼腥草、冬瓜仁、炒薏苡仁、芦根、贝母、皂角刺,桑白皮、黄芩、生甘草加入砂锅中,加 6 倍重量的冷水浸泡 60 分钟,武火煎至沸腾,文火煎煮 60 分钟,过滤得药液 a ;
b 、向砂锅加入 3-5 倍重量的水进行第二次煎煮,武火煎至沸腾后,按比例将羚羊角粉加入沸腾的药液中,文火煎煮 60 分钟,过滤得药液 b ;
c 、将药液 a 和 b 混合均匀,过滤得清液 c;
d 、向清液 c 中加 3 倍体积量的质量分数为 75% 的酒精,搅拌均匀,沉淀过夜,取上清液浓缩得浸膏,按常规工艺制备口服片剂。
实施例 2
一种治疗肺炎的中药,主要成分配比按重量份计:
重楼、蒲公英、败酱草各 30 份,鱼腥草、冬瓜仁、炒薏苡仁、芦根各 23 份,贝母、皂角刺各 15 份,桑白皮、黄芩各 10 份,生甘草 5 份;羚羊角粉 1 份。
根据以上工艺处方,具体制备方法如下:
a 、按比例将重楼、蒲公英、败酱草、鱼腥草、冬瓜仁、炒薏苡仁、芦根、贝母、皂角刺,桑白皮、黄芩、生甘草加入砂锅中,加 7 倍重量的冷水浸泡 90 分钟,武火煎至沸腾,文火煎煮 90 分钟,过滤得药液 a ;
b 、向砂锅加入 5 倍重量的水进行第二次煎煮,武火煎至沸腾后,按比例将羚羊角粉加入沸腾的药液中,文火煎煮 90 分钟,过滤得药液 b ;
c 、将药液 a 和 b 混合均匀,过滤得清液 c;
d 、向清液 c 中加 3 倍体积量的质量分数为 75% 的酒精,搅拌均匀,沉淀过夜,取上清液浓缩得浸膏,按常规工艺制备口服片剂。
实施例 3
一种治疗肺炎的中药,主要成分配比按重量份计:
重楼、蒲公英、败酱草各 38 份,鱼腥草、冬瓜仁、炒薏苡仁、芦根各 30 份,贝母、皂角刺各 22 份,桑白皮、黄芩各 15 份,生甘草 8 份;羚羊角粉 3 份。
根据以上工艺处方,具体制备方法如下:
   a 、按比例将重楼、蒲公英、败酱草、鱼腥草、冬瓜仁、炒薏苡仁、芦根、贝母、皂角刺,桑白皮、黄芩、生甘草加入砂锅中,加 6 倍重量的冷水浸泡 70 分钟,武火煎至沸腾,文火煎煮 70 分钟,过滤得药液 a ;
b 、向砂锅加入 4 倍重量的水进行第二次煎煮,武火煎至沸腾后,按比例将羚羊角粉加入沸腾的药液中,文火煎煮 80 分钟,过滤得药液 b ;
c 、将药液 a 和 b 混合均匀,过滤得清液 c;
d 、向清液 c 中加 3 倍体积量的质量分数为 75% 的酒精,搅拌均匀,沉淀过夜,取上清液浓缩得浸膏,按常规工艺制备口服片剂。
实施例 4
一种治疗肺炎的中药,主要成分配比按重量份计:
重楼、蒲公英、败酱草各 35 份,鱼腥草、冬瓜仁、炒薏苡仁、芦根各 25 份,贝母、皂角刺各 20 份,桑白皮、黄芩各 14 份,生甘草 6 份;羚羊角粉 2 份。
根据以上工艺处方,具体制备方法如下:
a 、按比例将重楼、蒲公英、败酱草、鱼腥草、冬瓜仁、炒薏苡仁、芦根、贝母、皂角刺,桑白皮、黄芩、生甘草加入砂锅中,加 6 倍重量的冷水浸泡 80 分钟,武火煎至沸腾,文火煎煮 60 分钟,过滤得药液 a ;
b 、向砂锅加入 3 倍重量的水进行第二次煎煮,武火煎至沸腾后,按比例将羚羊角粉加入沸腾的药液中,文火煎煮 70 分钟,过滤得药液 b ;
c 、将药液 a 和 b 混合均匀,过滤得清液 c;
d 、向清液 c 中加 3 倍体积量的质量分数为 75% 的酒精,搅拌均匀,沉淀过夜,取上清液浓缩得浸膏,按常规工艺制备口服片剂。
本发明临床观察的结果如下:
 痊愈:临床症状和体征完全消失或基本消失;
显效:临床症状和体征大部分好转或明显好转;
无效;临床症状和体征均无明显改善,症状如前,效果不明显。
治疗结果 :共 100 例患者,每实施例各 25 人服用,服药一个疗程后,症状均有所好转,服药 10 天后, 72 人痊愈, 18 人显效, 7 人有效, 3 人无效,总有效率为 97 %。

Claims (5)

1. 一种治疗肺炎的中药,其特征是:主要成分配比按重量份计为:
重楼、蒲公英、败酱草各 30-38 份,鱼腥草、冬瓜仁、炒薏苡仁、芦根各 23-30 份,贝母、皂角刺各 15-22 份,桑白皮、黄芩各 10-15 份,生甘草 5-8 份,羚羊角粉 1-3 份;
其制备方法具体步骤如下:
a 、按比例将重楼、蒲公英、败酱草、鱼腥草、冬瓜仁、炒薏苡仁、芦根、贝母、皂角刺、桑白皮、黄芩、生甘草加入砂锅中,加 6-7 倍重量的冷水浸泡 60-90 分钟,武火煎至沸腾,文火煎煮 60-90 分钟,过滤得药液 a ;
b 、向砂锅加入 3-5 倍重量的水进行第二次煎煮,武火煎至沸腾后,按比例将羚羊角粉加入沸腾的药液中,文火煎煮 60-90 分钟,过滤得药液 b ;
c 、将药液 a 和 b 混合均匀,过滤得清液 c;
d 、向清液 c 中加 3 倍体积量的质量分数为 75% 的酒精,搅拌均匀,沉淀过夜,取上清液浓缩得浸膏,按常规工艺制备口服片剂。
2. 根据权利要求 1 所述的一种治疗肺炎的中药,其特征是:重楼、蒲公英、败酱草各 30-35 份,鱼腥草、冬瓜仁、炒薏苡仁、芦根各 25-30 份,贝母、皂角刺各 15-20 份,桑白皮、黄芩各 10-15 份,生甘草 5-8 份,羚羊角粉 1-3 份。
3. 根据权利要求 1 所述的一种治疗肺炎的中药,其特征是:重楼、蒲公英、败酱草各 32 份,鱼腥草、冬瓜仁、炒薏苡仁、芦根各 26 份,贝母、皂角刺各 17 份,桑白皮、黄芩各 12 份,生甘草 6 份,羚羊角粉 2 份。
4. 一种治疗肺炎的中药的制备方法,其特征是:具体步骤如下:
a 、按比例将重楼、蒲公英、败酱草、鱼腥草、冬瓜仁、炒薏苡仁、芦根、贝母、皂角刺,桑白皮、黄芩、生甘草加入砂锅中,加 6-7 倍重量的冷水浸泡 60-90 分钟,武火煎至沸腾,文火煎煮 60-90 分钟,过滤得药液 a ;
b 、向砂锅加入 3-5 倍重量的水进行第二次煎煮,武火煎至沸腾后,按比例将羚羊角粉加入沸腾的药液中,文火煎煮 60-90 分钟,过滤得药液 b ;
c 、将药液 a 和 b 混合均匀,过滤得清液 c;
d 、向清液 c 中加 3 倍体积量的质量分数为 75% 的酒精,搅拌均匀,沉淀过夜,取上清液浓缩得浸膏,按常规工艺制备口服片剂。
5. 根据权利要求 4 所述的一种治疗肺炎的中药的制备方法,其特征是:浸泡时间 60-70 分钟;两次文火煎制时间均为 70-90 分钟。
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