WO2016193997A3 - Process for the preparation of 6-(3-chloro-2-fluorobenzyl)-1-[(2s)-1-hydroxy-3-methylbutan-2-yl]-7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid and pharmaceutically acceptable salts thereof - Google Patents

Process for the preparation of 6-(3-chloro-2-fluorobenzyl)-1-[(2s)-1-hydroxy-3-methylbutan-2-yl]-7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid and pharmaceutically acceptable salts thereof Download PDF

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Publication number
WO2016193997A3
WO2016193997A3 PCT/IN2016/000142 IN2016000142W WO2016193997A3 WO 2016193997 A3 WO2016193997 A3 WO 2016193997A3 IN 2016000142 W IN2016000142 W IN 2016000142W WO 2016193997 A3 WO2016193997 A3 WO 2016193997A3
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WO
WIPO (PCT)
Prior art keywords
methylbutan
dihydroquinoline
fluorobenzyl
oxo
chloro
Prior art date
Application number
PCT/IN2016/000142
Other languages
French (fr)
Other versions
WO2016193997A2 (en
Inventor
Srinivasan Thirumalai Rajan
Sajja Eswaraiah
Ghojala Venkat Reddy
Mallepally VENKAT REDDY
Original Assignee
Msn Laboratories Private Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Msn Laboratories Private Limited filed Critical Msn Laboratories Private Limited
Publication of WO2016193997A2 publication Critical patent/WO2016193997A2/en
Publication of WO2016193997A3 publication Critical patent/WO2016193997A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof
    • C07D215/32—Esters
    • C07D215/34—Carbamates

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to a process for the preparation of 6-(3-chloro-2-fluorobenzyl)-1-[(2S)-1-hydroxy-3-methylbutan-2-yl]-7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid represented by the following structural formula-1 and pharmaceutically acceptable salts thereof.
PCT/IN2016/000142 2015-06-03 2016-06-03 Process for the preparation of 6-(3-chloro-2-fluorobenzyl)-1-[(2s)-1-hydroxy-3-methylbutan-2-yl]-7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid and pharmaceutically acceptable salts thereof WO2016193997A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2784CH2015 2015-06-03
IN2784/CHE/2015 2015-06-03

Publications (2)

Publication Number Publication Date
WO2016193997A2 WO2016193997A2 (en) 2016-12-08
WO2016193997A3 true WO2016193997A3 (en) 2017-01-19

Family

ID=57441012

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2016/000142 WO2016193997A2 (en) 2015-06-03 2016-06-03 Process for the preparation of 6-(3-chloro-2-fluorobenzyl)-1-[(2s)-1-hydroxy-3-methylbutan-2-yl]-7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid and pharmaceutically acceptable salts thereof

Country Status (1)

Country Link
WO (1) WO2016193997A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114213450A (en) * 2021-12-29 2022-03-22 南京杰运医药科技有限公司 Synthesis method of methoxymethyl dimethoxysilane

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004046115A1 (en) * 2002-11-20 2004-06-03 Japan Tobacco Inc. 4-oxoquinoline compounds and utilization thereof as hiv integrase inhibitors
WO2011004389A2 (en) * 2009-06-18 2011-01-13 Matrix Laboratories Ltd An improved process for the preparation of elvitegravir
WO2014056464A1 (en) * 2012-10-12 2014-04-17 Zentiva, K.S. A new production method and new intermediates of synthesis of elvitegravir

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004046115A1 (en) * 2002-11-20 2004-06-03 Japan Tobacco Inc. 4-oxoquinoline compounds and utilization thereof as hiv integrase inhibitors
WO2011004389A2 (en) * 2009-06-18 2011-01-13 Matrix Laboratories Ltd An improved process for the preparation of elvitegravir
WO2014056464A1 (en) * 2012-10-12 2014-04-17 Zentiva, K.S. A new production method and new intermediates of synthesis of elvitegravir

Also Published As

Publication number Publication date
WO2016193997A2 (en) 2016-12-08

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