WO2015128875A3 - A process for preparation of dabigatran etexilate mesylate and intermediates thereof - Google Patents
A process for preparation of dabigatran etexilate mesylate and intermediates thereof Download PDFInfo
- Publication number
- WO2015128875A3 WO2015128875A3 PCT/IN2015/000100 IN2015000100W WO2015128875A3 WO 2015128875 A3 WO2015128875 A3 WO 2015128875A3 IN 2015000100 W IN2015000100 W IN 2015000100W WO 2015128875 A3 WO2015128875 A3 WO 2015128875A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- preparation
- dabigatran etexilate
- intermediates
- etexilate mesylate
- relates
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyrrole Compounds (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
The present invention relates to an improved process for the preparation of Dabigatran etexilate and its acid addition salts thereof, wherein the said process substantially eliminates the potential impurities. The present invention also relates to an intermediate of Dabigatran etexilate and process for preparation thereof.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN675/MUM/2014 | 2014-02-26 | ||
IN675MU2014 IN2014MU00675A (en) | 2014-02-26 | 2015-02-23 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2015128875A2 WO2015128875A2 (en) | 2015-09-03 |
WO2015128875A3 true WO2015128875A3 (en) | 2015-11-12 |
Family
ID=53267425
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IN2015/000100 WO2015128875A2 (en) | 2014-02-26 | 2015-02-23 | A process for preparation of dabigatran etexilate mesylate and intermediates thereof |
Country Status (2)
Country | Link |
---|---|
IN (1) | IN2014MU00675A (en) |
WO (1) | WO2015128875A2 (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105732433A (en) * | 2016-04-13 | 2016-07-06 | 山东新华制药股份有限公司 | Refining method of Dabigatran etexilate intermediate condensation compound |
CN110878083A (en) * | 2018-09-05 | 2020-03-13 | 连云港恒运药业有限公司 | Purification method of dabigatran etexilate intermediate |
CN111690699A (en) * | 2020-05-19 | 2020-09-22 | 浙江工业大学 | Method for enzymatic on-line synthesis of 3- (pyridine-2-amino) propylhydroxamic acid |
CN114113346B (en) * | 2020-08-25 | 2024-01-12 | 石药集团恩必普药业有限公司 | Detection method of ethyl p-toluenesulfonate and isopropyl p-toluenesulfonate in dabigatran etexilate bulk drug or preparation |
CN114716411B (en) * | 2022-04-29 | 2024-03-15 | 天方药业有限公司 | Method for recovering and preparing dabigatran etexilate mesylate from production mother liquor |
CN115417855A (en) * | 2022-09-22 | 2022-12-02 | 安徽美诺华药物化学有限公司 | Synthesis process of dabigatran etexilate mesylate |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050107409A1 (en) * | 2003-03-10 | 2005-05-19 | Boehringer Ingelheim International Gmbh | Aromatic bicyclic compounds, preparation thereof and their use as pharmaceutical compositions |
US20050234104A1 (en) * | 2003-08-29 | 2005-10-20 | Boehringer Ingelheim International Gmbh | 3-[(2-{[4-(hexyloxycarbonylaminoiminomethyl)phenylamino]methyl}-1-methyl-1H-benzimidazol-5-carbonyl)pyridin-2-ylamino]propionic acid ethylester methansulfonate and its use as medicament |
WO2009111997A1 (en) * | 2008-03-14 | 2009-09-17 | Zentiva, K.S. | A method for the preparation of dabigatran |
EP2522662A1 (en) * | 2011-05-11 | 2012-11-14 | Medichem, S.A. | Dabigatran etexilate and related substances, processes and compositions, and use of the substances as reference standards and markers |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PE121699A1 (en) | 1997-02-18 | 1999-12-08 | Boehringer Ingelheim Pharma | BICYCLE HETERO CYCLES DISSTITUTED AS INHIBITORS OF THROMBIN |
EP1609784A1 (en) | 2004-06-25 | 2005-12-28 | Boehringer Ingelheim Pharma GmbH & Co.KG | Process for the preparation of 4-(benzimidazolylmethylamino)-benzamidines |
DE102005025728A1 (en) | 2005-06-04 | 2006-12-07 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Polymorphs of 3 - [(2 - {[4- (hexyloxycarbonylamino-imino-methyl) -phenyl-amino] -methyl} -1-methyl-1H-benzimidazole-5-carbonyl) -pyridin-2-yl-amino] -propionic acid ethyl ester |
ITTO20050486A1 (en) | 2005-07-14 | 2005-10-13 | Dumitru Bucuresteanu | AIR OPERATING COMPRESSOR WITH CONTINUOUS PROPELLER IN A TURNTABLE TUBE |
DE102006054005A1 (en) | 2006-11-16 | 2008-05-21 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | New polymorphs of 3 - [(2 - {[4- (hexyloxycarbonylamino-imino-methyl) -phenyl-amino] -methyl} -1-methyl-1H-benzimidazole-5-carbonyl) -pyridin-2-yl-amino] -propionic acid ethyl |
CZ2008669A3 (en) | 2008-10-24 | 2010-05-05 | Zentiva, A. S. | Process for preparing dabigatran and intermediates thereof |
HUP1100244A2 (en) | 2011-05-11 | 2012-11-28 | Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag | Pharmaceutical intermediates and process for their production |
-
2015
- 2015-02-23 WO PCT/IN2015/000100 patent/WO2015128875A2/en active Application Filing
- 2015-02-23 IN IN675MU2014 patent/IN2014MU00675A/en unknown
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050107409A1 (en) * | 2003-03-10 | 2005-05-19 | Boehringer Ingelheim International Gmbh | Aromatic bicyclic compounds, preparation thereof and their use as pharmaceutical compositions |
US20050234104A1 (en) * | 2003-08-29 | 2005-10-20 | Boehringer Ingelheim International Gmbh | 3-[(2-{[4-(hexyloxycarbonylaminoiminomethyl)phenylamino]methyl}-1-methyl-1H-benzimidazol-5-carbonyl)pyridin-2-ylamino]propionic acid ethylester methansulfonate and its use as medicament |
WO2009111997A1 (en) * | 2008-03-14 | 2009-09-17 | Zentiva, K.S. | A method for the preparation of dabigatran |
EP2522662A1 (en) * | 2011-05-11 | 2012-11-14 | Medichem, S.A. | Dabigatran etexilate and related substances, processes and compositions, and use of the substances as reference standards and markers |
Also Published As
Publication number | Publication date |
---|---|
IN2014MU00675A (en) | 2015-10-23 |
WO2015128875A2 (en) | 2015-09-03 |
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