WO2016181228A2 - Systems and methods for growing a biofilm of probiotic bacteria on solid particles for colonization of bacteria in the gut - Google Patents
Systems and methods for growing a biofilm of probiotic bacteria on solid particles for colonization of bacteria in the gut Download PDFInfo
- Publication number
- WO2016181228A2 WO2016181228A2 PCT/IB2016/000933 IB2016000933W WO2016181228A2 WO 2016181228 A2 WO2016181228 A2 WO 2016181228A2 IB 2016000933 W IB2016000933 W IB 2016000933W WO 2016181228 A2 WO2016181228 A2 WO 2016181228A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- biofilm
- bacteria
- particles
- population
- strain
- Prior art date
Links
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- 239000002245 particle Substances 0.000 title claims abstract description 100
- 238000000034 method Methods 0.000 title claims abstract description 47
- 239000006041 probiotic Substances 0.000 title description 10
- 230000000529 probiotic effect Effects 0.000 title description 10
- 235000018291 probiotics Nutrition 0.000 title description 10
- 239000007787 solid Substances 0.000 title description 8
- 230000001580 bacterial effect Effects 0.000 claims abstract description 37
- 239000001963 growth medium Substances 0.000 claims abstract description 26
- 238000012258 culturing Methods 0.000 claims abstract description 7
- 210000001035 gastrointestinal tract Anatomy 0.000 claims description 57
- 240000006024 Lactobacillus plantarum Species 0.000 claims description 21
- 230000003068 static effect Effects 0.000 claims description 17
- NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 claims description 15
- 235000019739 Dicalciumphosphate Nutrition 0.000 claims description 13
- 239000001506 calcium phosphate Substances 0.000 claims description 13
- 229940038472 dicalcium phosphate Drugs 0.000 claims description 13
- 229910000390 dicalcium phosphate Inorganic materials 0.000 claims description 13
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- 241000923672 Acetobacter pomorum Species 0.000 claims description 6
- 235000013965 Lactobacillus plantarum Nutrition 0.000 claims description 6
- 230000001419 dependent effect Effects 0.000 claims description 6
- 229940072205 lactobacillus plantarum Drugs 0.000 claims description 6
- 244000005709 gut microbiome Species 0.000 claims description 2
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- 238000002474 experimental method Methods 0.000 description 8
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- 241001529936 Murinae Species 0.000 description 3
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- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
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- 229910052760 oxygen Inorganic materials 0.000 description 2
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- 239000000243 solution Substances 0.000 description 2
- 238000010186 staining Methods 0.000 description 2
- 230000037351 starvation Effects 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- 230000004083 survival effect Effects 0.000 description 2
- 241000186660 Lactobacillus Species 0.000 description 1
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- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 241000699660 Mus musculus Species 0.000 description 1
- 241000589516 Pseudomonas Species 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000000440 bentonite Substances 0.000 description 1
- 229910000278 bentonite Inorganic materials 0.000 description 1
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 1
- 230000032770 biofilm formation Effects 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000012737 fresh medium Substances 0.000 description 1
- 229940039696 lactobacillus Drugs 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 238000001000 micrograph Methods 0.000 description 1
- 238000011580 nude mouse model Methods 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
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- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
- C12N11/04—Enzymes or microbial cells immobilised on or in an organic carrier entrapped within the carrier, e.g. gel or hollow fibres
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
- C12N11/10—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a carbohydrate
- C12N11/12—Cellulose or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/14—Enzymes or microbial cells immobilised on or in an inorganic carrier
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/11—Lactobacillus
- A23V2400/169—Plantarum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K2035/11—Medicinal preparations comprising living procariotic cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K2035/11—Medicinal preparations comprising living procariotic cells
- A61K2035/115—Probiotics
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Mycology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Dispersion Chemistry (AREA)
- Nutrition Science (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Description
Claims
Priority Applications (16)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP16792262.4A EP3294073B1 (en) | 2015-05-11 | 2016-05-09 | Systems and methods for growing a biofilm of probiotic bacteria on solid particles for colonization of bacteria in the gut |
AU2016259871A AU2016259871B2 (en) | 2015-05-11 | 2016-05-09 | Systems and methods for growing a biofilm of probiotic bacteria on solid particles for colonization of bacteria in the gut |
RU2017143181A RU2773533C9 (en) | 2015-05-11 | 2016-05-09 | Systems and methods for growing probiotic bacterium biofilm on solid particles for intestine colonization by bacteria |
CN201680038473.8A CN108135240B (en) | 2015-05-11 | 2016-05-09 | System and method for growing probiotic biofilm on solid particulates for colonizing bacteria in the intestinal tract |
CA2985729A CA2985729C (en) | 2015-05-11 | 2016-05-09 | Systems and methods for growing a biofilm of probiotic bacteria on solid particles for colonization of bacteria in the gut |
JP2018511533A JP6990922B2 (en) | 2015-05-11 | 2016-05-09 | Systems and methods for growing live bacterial biofilms on solid particles for bacterial colonization in the intestine |
BR112017024265-6A BR112017024265B1 (en) | 2015-05-11 | 2016-05-09 | METHODS FOR GROWING A BIOFILM OF PROBIOTIC BACTERIA IN SOLID PARTICLES |
CN202210612650.6A CN114990099A (en) | 2015-05-11 | 2016-05-09 | System and method for growing probiotic biofilm on solid particulates for colonizing bacteria in the intestinal tract |
DK16792262.4T DK3294073T3 (en) | 2015-05-11 | 2016-05-09 | SYSTEMS AND METHODS FOR CULTIVATING A BIOFILM OF PROBIOTIC BACTERIA ON SOLID PARTICLES FOR COLONIZING BACTERIA IN THE INTESTINES |
US15/572,972 US10793847B2 (en) | 2015-05-11 | 2016-05-09 | Systems and methods for growing a biofilm of probiotic bacteria on solid particles for colonization of bacteria in the gut |
ES16792262T ES2929893T3 (en) | 2015-05-11 | 2016-05-09 | Systems and methods for growing a biofilm of probiotic bacteria on solid particles for colonization of bacteria in the intestine |
IL255583A IL255583B (en) | 2015-05-11 | 2017-11-09 | Systems and methods for growing a biofilm of probiotic bacteria on solid particles for colonization of bacteria in the gut |
US17/031,271 US11680257B2 (en) | 2015-05-11 | 2020-09-24 | Systems and methods for growing a biofilm of probiotic bacteria on solid particles for colonization of bacteria in the gut |
US17/031,436 US11001828B2 (en) | 2015-05-11 | 2020-09-24 | Systems and methods for growing a biofilm of probiotic bacteria on solid particles for colonization of bacteria in the gut |
IL287585A IL287585A (en) | 2015-05-11 | 2021-10-26 | Systems and methods for growing a biofilm of probiotic bacteria on solid particles for colonization of bacteria in the gut |
US18/126,459 US20230227806A1 (en) | 2015-05-11 | 2023-03-26 | Systems and methods for growing a biofilm of probiotic bacteria on solid particles for colonization of bacteria in the gut |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562159846P | 2015-05-11 | 2015-05-11 | |
US201562159849P | 2015-05-11 | 2015-05-11 | |
US62/159,846 | 2015-05-11 | ||
US62/159,849 | 2015-05-11 |
Related Child Applications (3)
Application Number | Title | Priority Date | Filing Date |
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US15/572,972 A-371-Of-International US10793847B2 (en) | 2015-05-11 | 2016-05-09 | Systems and methods for growing a biofilm of probiotic bacteria on solid particles for colonization of bacteria in the gut |
US17/031,271 Continuation US11680257B2 (en) | 2015-05-11 | 2020-09-24 | Systems and methods for growing a biofilm of probiotic bacteria on solid particles for colonization of bacteria in the gut |
US17/031,436 Continuation US11001828B2 (en) | 2015-05-11 | 2020-09-24 | Systems and methods for growing a biofilm of probiotic bacteria on solid particles for colonization of bacteria in the gut |
Publications (2)
Publication Number | Publication Date |
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WO2016181228A2 true WO2016181228A2 (en) | 2016-11-17 |
WO2016181228A3 WO2016181228A3 (en) | 2017-01-05 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IB2016/000933 WO2016181228A2 (en) | 2015-05-11 | 2016-05-09 | Systems and methods for growing a biofilm of probiotic bacteria on solid particles for colonization of bacteria in the gut |
Country Status (11)
Country | Link |
---|---|
US (4) | US10793847B2 (en) |
EP (1) | EP3294073B1 (en) |
JP (2) | JP6990922B2 (en) |
CN (2) | CN114990099A (en) |
AU (1) | AU2016259871B2 (en) |
BR (1) | BR112017024265B1 (en) |
CA (1) | CA2985729C (en) |
DK (1) | DK3294073T3 (en) |
ES (1) | ES2929893T3 (en) |
IL (2) | IL255583B (en) |
WO (1) | WO2016181228A2 (en) |
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
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CN109562132A (en) * | 2016-05-25 | 2019-04-02 | 迈彼欧提克斯制药有限公司 | Composition and method for microbiota therapy |
KR20190092574A (en) * | 2016-12-28 | 2019-08-07 | 인벤사스 본딩 테크놀로지스 인코포레이티드 | Processing of Laminated Substrates |
WO2020092940A1 (en) * | 2018-11-01 | 2020-05-07 | Pivot Bio, Inc. | Biofilm compositions with improved stability for nitrogen fixing microbial products |
WO2020194319A1 (en) * | 2019-03-28 | 2020-10-01 | Mybiotics Pharma Ltd. | Probiotic biofilm compositions and methods of preparing same |
US10919814B2 (en) | 2015-07-13 | 2021-02-16 | Pivot Bio, Inc. | Methods and compositions for improving plant traits |
EP3630944A4 (en) * | 2017-05-29 | 2021-03-31 | The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organization (ARO) (Volcani Center) | Method of generation bacterial compositions comprising a biofilm with benefecial bacteria |
US11297868B2 (en) | 2016-05-29 | 2022-04-12 | The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization (Aro) (Volcani Center) | Method of generating bacterial compositions |
US11479516B2 (en) | 2015-10-05 | 2022-10-25 | Massachusetts Institute Of Technology | Nitrogen fixation using refactored NIF clusters |
US11565979B2 (en) | 2017-01-12 | 2023-01-31 | Pivot Bio, Inc. | Methods and compositions for improving plant traits |
US11680257B2 (en) | 2015-05-11 | 2023-06-20 | Mybiotics Pharma Ltd. | Systems and methods for growing a biofilm of probiotic bacteria on solid particles for colonization of bacteria in the gut |
US11678667B2 (en) | 2018-06-27 | 2023-06-20 | Pivot Bio, Inc. | Agricultural compositions comprising remodeled nitrogen fixing microbes |
WO2023119287A1 (en) * | 2021-12-22 | 2023-06-29 | The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization (Aro) (Volcani Institute) | Nomadic bacteria and uses thereof |
US11946162B2 (en) | 2012-11-01 | 2024-04-02 | Massachusetts Institute Of Technology | Directed evolution of synthetic gene cluster |
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CN110051698A (en) * | 2019-03-18 | 2019-07-26 | 天津大学 | The method of enteron aisle probiotics genetic modification based on microencapsulation processing |
WO2021041981A1 (en) | 2019-08-28 | 2021-03-04 | Assembly Biosciences, Inc. | Compositions comprising bacterial species and methods related thereto |
CN111012804B (en) * | 2019-12-16 | 2022-05-17 | 南京大学 | Probiotic mineral material composite preparation and application of mineral material in preparation of medicine for inhibiting malignant tumor growth |
IL286748A (en) * | 2021-09-27 | 2023-04-01 | Mybiotics Pharma Ltd | Microbial compositions and methods of preparing same |
Citations (1)
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DE202013103204U1 (en) | 2013-07-17 | 2013-07-26 | Pharmaceutical Biotechnology S.R.O. | Preparation containing a probiotic culture |
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EP1137423B1 (en) | 1998-12-11 | 2005-03-09 | Urex Biotech, Inc. | Oral administration of lactobacillus for the treatment and prevention of urogenital infection |
JP4396078B2 (en) | 1999-12-17 | 2010-01-13 | チッソ株式会社 | Microorganism incubator and microorganism medium using the same |
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Also Published As
Publication number | Publication date |
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EP3294073B1 (en) | 2022-08-10 |
ES2929893T3 (en) | 2022-12-02 |
CN108135240B (en) | 2022-06-17 |
AU2016259871A1 (en) | 2018-01-04 |
BR112017024265B1 (en) | 2022-08-09 |
AU2016259871B2 (en) | 2020-04-16 |
RU2017143181A3 (en) | 2019-10-18 |
US10793847B2 (en) | 2020-10-06 |
CN114990099A (en) | 2022-09-02 |
RU2017143181A (en) | 2019-06-13 |
DK3294073T3 (en) | 2022-11-14 |
US11680257B2 (en) | 2023-06-20 |
CA2985729C (en) | 2023-05-09 |
CN108135240A (en) | 2018-06-08 |
JP2018517430A (en) | 2018-07-05 |
US20230227806A1 (en) | 2023-07-20 |
US20210009985A1 (en) | 2021-01-14 |
US11001828B2 (en) | 2021-05-11 |
CA2985729A1 (en) | 2016-11-17 |
JP6990922B2 (en) | 2022-01-12 |
IL255583A (en) | 2018-01-31 |
IL255583B (en) | 2021-10-31 |
IL287585A (en) | 2021-12-01 |
WO2016181228A3 (en) | 2017-01-05 |
EP3294073A4 (en) | 2019-03-13 |
BR112017024265A2 (en) | 2018-07-24 |
EP3294073A2 (en) | 2018-03-21 |
JP2021104042A (en) | 2021-07-26 |
US20180355343A1 (en) | 2018-12-13 |
US20210002627A1 (en) | 2021-01-07 |
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