WO2016144121A3 - 케라틴 조직의 진균감염증 치료를 위한 약제학적 조성물 - Google Patents

케라틴 조직의 진균감염증 치료를 위한 약제학적 조성물 Download PDF

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Publication number
WO2016144121A3
WO2016144121A3 PCT/KR2016/002415 KR2016002415W WO2016144121A3 WO 2016144121 A3 WO2016144121 A3 WO 2016144121A3 KR 2016002415 W KR2016002415 W KR 2016002415W WO 2016144121 A3 WO2016144121 A3 WO 2016144121A3
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WO
WIPO (PCT)
Prior art keywords
ketratin
pharmaceutical composition
infectious diseases
tissue
fungal infectious
Prior art date
Application number
PCT/KR2016/002415
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English (en)
French (fr)
Other versions
WO2016144121A2 (ko
Inventor
손미원
전준호
박형근
한상덕
최성락
Original Assignee
동아제약 주식회사
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 동아제약 주식회사 filed Critical 동아제약 주식회사
Priority claimed from KR1020160028730A external-priority patent/KR101799008B1/ko
Publication of WO2016144121A2 publication Critical patent/WO2016144121A2/ko
Publication of WO2016144121A3 publication Critical patent/WO2016144121A3/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/133—Amines having hydroxy groups, e.g. sphingosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides

Abstract

본 발명은 케라틴조직의 진균감염증 치료를 위해 약물투과를 향상시키는 약제학적 조성물, 제조방법 및 그 투여방법에 관한 것으로서, 구체적으로는 a) 적어도 하나 이상의 항진균성 활성물질; b) pH 7 ~ pH 13으로 할 수 있는 알칼리화제; 및 c) 항진균 활성성분을 용해하거나 흡수를 촉진하는 유기용매를 함유하여 케라틴 조직의 흡수를 증가시켜 진균감염증을 예방 및 치료하기 위한 약제학적 조성물, 제조방법 및 투여방법에 관한 것이다.
PCT/KR2016/002415 2015-03-12 2016-03-10 케라틴 조직의 진균감염증 치료를 위한 약제학적 조성물 WO2016144121A2 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR10-2015-0034395 2015-03-12
KR20150034395 2015-03-12
KR1020160028730A KR101799008B1 (ko) 2015-03-12 2016-03-10 케라틴 조직의 진균감염증 치료를 위한 약제학적 조성물
KR10-2016-0028730 2016-03-10

Publications (2)

Publication Number Publication Date
WO2016144121A2 WO2016144121A2 (ko) 2016-09-15
WO2016144121A3 true WO2016144121A3 (ko) 2016-11-03

Family

ID=56879674

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2016/002415 WO2016144121A2 (ko) 2015-03-12 2016-03-10 케라틴 조직의 진균감염증 치료를 위한 약제학적 조성물

Country Status (1)

Country Link
WO (1) WO2016144121A2 (ko)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20030079766A (ko) * 2002-04-05 2003-10-10 융 신 파마세티칼 인더스트리알 컴파니 리미티드 항진균 포뮬레이션, 그의 제조 방법 및 사용 방법
US6846837B2 (en) * 2002-06-21 2005-01-25 Howard I. Maibach Topical administration of basic antifungal compositions to treat fungal infections of the nails
KR20070072482A (ko) * 2004-10-08 2007-07-04 메디퀘스트 테라퓨틱스 아이엔씨. 치료적 응용을 위한 유기겔 제제형
JP4784051B2 (ja) * 2003-07-03 2011-09-28 大正製薬株式会社 容器への吸着を防止した外用抗真菌組成物
JP5435836B2 (ja) * 2003-07-03 2014-03-05 大正製薬株式会社 外用抗真菌剤組成物

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20030079766A (ko) * 2002-04-05 2003-10-10 융 신 파마세티칼 인더스트리알 컴파니 리미티드 항진균 포뮬레이션, 그의 제조 방법 및 사용 방법
US6846837B2 (en) * 2002-06-21 2005-01-25 Howard I. Maibach Topical administration of basic antifungal compositions to treat fungal infections of the nails
JP4784051B2 (ja) * 2003-07-03 2011-09-28 大正製薬株式会社 容器への吸着を防止した外用抗真菌組成物
JP5435836B2 (ja) * 2003-07-03 2014-03-05 大正製薬株式会社 外用抗真菌剤組成物
KR20070072482A (ko) * 2004-10-08 2007-07-04 메디퀘스트 테라퓨틱스 아이엔씨. 치료적 응용을 위한 유기겔 제제형

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