WO2016132274A1 - Granulat à base de matrice minérale, avec libération progressive et contrôlée de nutriments et/ou de substances pharmacologiques, et son procédé de fourniture - Google Patents

Granulat à base de matrice minérale, avec libération progressive et contrôlée de nutriments et/ou de substances pharmacologiques, et son procédé de fourniture Download PDF

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Publication number
WO2016132274A1
WO2016132274A1 PCT/IB2016/050794 IB2016050794W WO2016132274A1 WO 2016132274 A1 WO2016132274 A1 WO 2016132274A1 IB 2016050794 W IB2016050794 W IB 2016050794W WO 2016132274 A1 WO2016132274 A1 WO 2016132274A1
Authority
WO
WIPO (PCT)
Prior art keywords
granules
urea
mixing
magnesium chloride
mixture
Prior art date
Application number
PCT/IB2016/050794
Other languages
English (en)
Inventor
Luigino Bortolotto
Original Assignee
Sintal S.R.L.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sintal S.R.L. filed Critical Sintal S.R.L.
Priority to EP16715867.4A priority Critical patent/EP3258915A1/fr
Publication of WO2016132274A1 publication Critical patent/WO2016132274A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0068—Rumen, e.g. rumen bolus
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/158—Fatty acids; Fats; Products containing oils or fats
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/20—Inorganic substances, e.g. oligoelements
    • A23K20/24—Compounds of alkaline earth metals, e.g. magnesium
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/20—Inorganic substances, e.g. oligoelements
    • A23K20/28—Silicates, e.g. perlites, zeolites or bentonites
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K40/00—Shaping or working-up of animal feeding-stuffs
    • A23K40/10—Shaping or working-up of animal feeding-stuffs by agglomeration; by granulation, e.g. making powders
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K40/00—Shaping or working-up of animal feeding-stuffs
    • A23K40/30—Shaping or working-up of animal feeding-stuffs by encapsulating; by coating
    • A23K40/35—Making capsules specially adapted for ruminants
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/10—Feeding-stuffs specially adapted for particular animals for ruminants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5015—Organic compounds, e.g. fats, sugars

Definitions

  • the present invention relates to a granulate based on a mineral matrix, with gradual and controlled release of nutrient and/or pharmacological substances, and to a method for providing it.
  • the ruminal microbiota is also capable of using inorganic nitrogen to synthesize proteins; in particular, urea is hydrolyzed by the urease activity of ruminal microorganisms into carbon dioxide and ammonia; the latter is absorbed by ruminal microorganisms and converted into bacterial protein.
  • urea is hydrolyzed by the urease activity of ruminal microorganisms into carbon dioxide and ammonia; the latter is absorbed by ruminal microorganisms and converted into bacterial protein.
  • the walls of the rumen are permeable to ammonia, which if present in excess can cause an even severe intoxication of the animal; for this reason, food urea disappears rapidly from the rumen after ingestion and in this manner synchronization between the processes for fermentation of carbohydrates and fibers and the availability of inorganic nitrogen to be used for protein synthesis of ruminal microorganisms is lost.
  • additive and/or pharmacological substances are easily available in powder form to be mixed with feeds, but especially when animals live on pasture, such as bovines and ovines, they are difficult to administer, even more so if administration has to be repeated periodically over time.
  • boluses are in fact compounds that are constituted usually by a matrix in which the food additives and the biologically active substances requiring solubility control over time are dispersed.
  • the matrix is commonly constituted by using polymers of various kinds, for example the vegetable resin rosin (or colophony) or some hydrogenated fats, which are used typically to convey, for example, the amino acid methionine and vitamin B4 choline, avoiding their ruminal degradation, or again proteins such as zein are used.
  • polymers of various kinds for example the vegetable resin rosin (or colophony) or some hydrogenated fats, which are used typically to convey, for example, the amino acid methionine and vitamin B4 choline, avoiding their ruminal degradation, or again proteins such as zein are used.
  • urea is known as a nitrogenous fertilizer.
  • the soil thanks to particular enzymes, is capable of hydrolyzing urea into ammonia and carbon dioxide, thus making the nitrogen available for plants.
  • Urea is also widely used in cosmetics, for example in moisturizing creams and for the treatment of dermatological disorders.
  • the granulate operations typically occur in adapted machines, such as for example, a mixer, a coating pan or a fluid bed, which are unable to ensure correct solidification of the granules.
  • adapted machines such as for example, a mixer, a coating pan or a fluid bed, which are unable to ensure correct solidification of the granules.
  • the result is in fact a product constituted by urea particles immersed in a mineral matrix, in the form of agglomerations and not granular.
  • the aim of the present invention is to provide a granulate based on a mineral matrix for which it is possible to modulate the solubility kinetics and the rate of release of any nutrients or additives and/or pharmacological substances added to the matrix.
  • an object of the invention is to devise a granulate that can be used both in the zootechnical field as well as in other sectors such as agriculture and cosmetics, for example to cover nutritional needs in animals, to fertilize the soil and for aesthetic and curative treatments.
  • a granulate based on a mineral matrix with gradual and controlled release of nutrient and/or pharmacological substances, said mineral matrix comprising:
  • said granulate being characterized in that it comprises urea and fats.
  • the present invention also relates to a method for providing a granulate, characterized in that it comprises the following steps:
  • the granulate according to the invention is a product based on a mineral matrix.
  • magnesium chloride - 5% to 90% magnesium chloride, - 5% to 80% magnesium oxide.
  • a mineral matrix that comprises:
  • the particularity of the granulate according to the invention resides in that it also comprises urea and fats, of which urea is the active ingredient of the granulate.
  • fatty acids monoglycerides, diglycerides, triglycerides and waxes, as well as stearates of calcium, sodium and magnesium.
  • Hydrogenated or fractionated palm oil hydrogenated sunflower oil, hydrogenated soybean oil, carnauba wax and candelilla wax are preferable.
  • the granulate also comprises silicates, which reduce the porosity of the matrix, increasing urea protection.
  • part of the silicates and fats can be replaced with oxides or other salts of copper, zinc, manganese, iron, but also salts of cobalt, selenium, iodine, so as to provide these nutrients as well.
  • iron oxides can have the function of coloring the preparations, not only those for ruminants, and for this purpose it is also possible to use many other colors, such as for example cupric chlorophyll and titanium oxide.
  • the silicates and fats can be partially replaced also with carbonates and sulfates of calcium, sodium and magnesium.
  • the silicates are constituted preferably by a mixture of silicon dioxide and calcium silicate, but as an alternative it is possible to use all the silicates and agglomerating agents alone or in a mixture, i.e.: sodium silicate, sodium metasilicate, colloidal silica, diatomaceous earth, magnesium silicate, magnesium trisilicate, talc, sodium and aluminum silicate, potassium and aluminum silicate, calcium and aluminum silicate, bentonite- montmorillonite, aluminum silicate, natural mixture of steatite and chlorite, vermiculite, sepiolite, sepiolite clay, lignosulfonates, nartolite-fonolite, volcanic clinoptilolite, sedimentary clinopltilolite, pearlite.
  • a granulate comprising the above cited components in percentage quantity comprised in the following ranges can be of particular interest:
  • the granulate can comprise:
  • Figure 1 shows a chart that represents the solubility of urea over time for a preparation without a mineral matrix, the curve of which is designated by the reference numeral 1 , and for three preparations based on the three different mineral matrices cited above.
  • the chart plots on the ordinates the percentage of urea in solution, indicated by the letter U, and on the abscissae the time in minutes, indicated by the letter T.
  • the other three curves are designated by the reference numeral 2 for the granulate based on a mineral matrix containing 30% magnesium oxide, by the reference numeral 3 for the granulate based on a mineral matrix containing 50% magnesium oxide, and by the reference numeral 4 for the granulate based on a mineral matrix containing 75% magnesium oxide.
  • the chart shows that the solubilization kinetics of the urea differ among each other and significantly from the products without the mineral matrix, for which, in a distinctly shorter time, the urea is completely in solution.
  • the method may depend on the apparatus that one intends to use.
  • the method for providing the granulate comprises the following steps:
  • the method for providing the granulate according to the invention comprises the following steps:
  • the formation of the granules can occur in a mixer or with an atomization of the solution in a fluid bed or in a mushroom mixer.
  • the product undergoes storage substantially of the dynamic type, since it is placed in adapted containers and is moved at set intervals.
  • the method for providing the granulate according to the invention comprises the following steps:
  • Granule maturation can occur in this case also in a mushroom mixer or in a fluid bed or even in a mixture, therefore with dynamic storage.
  • emulsifying agents for example lecithins
  • a solution constituted by 20% water and 50% magnesium chloride it is possible to add a quantity equal to 30% of hydrogenated palm oil and by mixing vigorously at a temperature of approximately 70°C or in any case at a temperature that is higher than the melting point of the fat or wax being used ⁇ one obtains a fluid emulsion.
  • the magnesium chloride acts as an emulsifier for the palm oil. In this manner, contrary to what one might expect, no emulsifying additives are needed.
  • the method for providing the granulate according to the invention comprises the following steps:
  • the maturation of the granules can be performed, as in the first example, with static storage.
  • the granulate according to the invention during the step for granule maturation and therefore crystallization of the mineral matrix it is possible to utilize the natural tendency of the fat to arrange itself on the surface of an aqueous liquid to create a film on the surface of the granules generated during the process and thus facilitate their separation and also improve the insulation and impermeabilization characteristics of the preparation.
  • the product is placed in adapted containers, for example cisterns, silos, bag and big bags, and is not moved until maturation is completed.
  • adapted containers for example cisterns, silos, bag and big bags
  • the product is placed in adapted containers and moved at preset time intervals.
  • the product can be stored in a big bag and after a preset time it has to be transferred into another big bag.
  • Movement can occur by simple free transfer from one container to another or by guided transfer, for example with the aid of a chute.
  • a mechanical conveyance system for example with screw feeders or other conveyors of the belt, tray or vane type, or also with pneumatic conveyance systems.
  • This operation for dynamic storage can be performed also inside a machine, for example a mixer by means of the actuation of which the product can be moved. In this case transfer of the product is therefore not necessary, but only its movement.
  • Maturation with dynamic storage can therefore occur also within the machines themselves used to form the granules, therefore a mixer, a fluid bed or a mushroom mixer.
  • the choice of the type of storage for the maturation step depends on the intended use of the preparation and therefore on its specific formulation and on the granulation method implemented.
  • the produced granule When using urea with particle size of less than approximately 1 mm, the produced granule has the appearance of an aggregate of a plurality of particles of active ingredient immersed in the mineral matrix.
  • urea with larger dimensions it is possible to obtain a product in which each individual urea particle is wrapped by a layer of mineral matrix, creating a protective coating that modulates the solubilization of the active ingredient.
  • urea is an active ingredient that is used not only in preparations intended for farming and zootechny but is also widely used for pharmaceutical and cosmetic preparations, for example in creams for simple moisturization or for treating skin disorders.
  • the coating of the granule with a lipid film can be very useful in regulating the micromassage effect, and the effect of the matrix can be used also to obtain a peeling or scrub action.
  • a granulate to be used in cosmetics can be constituted by a percentage of urea that is distinctly different from the one required for feeding ruminants and the matrix can have a different composition with respect to the ones presented in the preceding examples; in particular, the relative quantity of magnesium oxide is lower in order to obtain an aggregate that is less hard and more suitable for peeling.
  • the granulate according to the invention can be modified in its composition percentages depending on the type of intended use, in order to provide specific products according to the requirements, therefore for example as a function of the type of diet of the animal or of the type of soil or also as a function of the skin problem to be treated in humans.
  • the mineral matrix that is used is of natural origin, due to the origin of its components, which are already extensively used in the cited sectors and are also relatively of low cost.
  • the invention achieves the intended aim and object, by providing a granulate based on a mineral matrix, and also proposing some methods for providing it, for which it is possible to modulate the solubility kinetics and the rate of release of any nutrients or additives and/or pharmacological substances added to the matrix and can be used both in the zootechnical sector and in other sectors such as agriculture and cosmetics.
  • the materials used may be any according to requirements and to the state of the art.

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Zoology (AREA)
  • Animal Husbandry (AREA)
  • Public Health (AREA)
  • Inorganic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Birds (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Fodder In General (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention concerne un granulat à base de matrice minérale, avec libération progressive et contrôlée de nutriments et/ou de substances pharmacologiques, et son procédé de fourniture. La matrice minérale comprend : - 1 % à 50 % d'eau, - 5 % à 90 % de chlorure de magnésium, - 5 % à 80 % d'oxyde de magnésium. Le granulat comprend également de l'urée et des matières grasses. Le procédé comprend les étapes suivantes : - la formation par voie humide de granulés par mélange d'un mélange contenant au moins de l'urée et des silicates avec une solution qui contient au moins de l'eau et du chlorure de magnésium, de manière sélective, un parmi le mélange et la solution comprenant l'oxyde de magnésium, - la liaison des matières grasses à, de manière sélective, un parmi le mélange, la solution ou les granulés, - la maturation des granulés.
PCT/IB2016/050794 2015-02-16 2016-02-15 Granulat à base de matrice minérale, avec libération progressive et contrôlée de nutriments et/ou de substances pharmacologiques, et son procédé de fourniture WO2016132274A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP16715867.4A EP3258915A1 (fr) 2015-02-16 2016-02-15 Granulat à base de matrice minérale, avec libération progressive et contrôlée de nutriments et/ou de substances pharmacologiques, et son procédé de fourniture

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITPD20150041 2015-02-16
ITPD2015A000041 2015-02-16

Publications (1)

Publication Number Publication Date
WO2016132274A1 true WO2016132274A1 (fr) 2016-08-25

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PCT/IB2016/050794 WO2016132274A1 (fr) 2015-02-16 2016-02-15 Granulat à base de matrice minérale, avec libération progressive et contrôlée de nutriments et/ou de substances pharmacologiques, et son procédé de fourniture

Country Status (2)

Country Link
EP (1) EP3258915A1 (fr)
WO (1) WO2016132274A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT201800005063A1 (it) * 2018-05-04 2019-11-04 Preparato per prodotti enologici

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1009134A (en) * 1960-10-17 1965-11-10 Tranatogen Werk Jakob Schwarzk A process for the production of mineral mixture for livestock
FR2987560A3 (fr) * 2012-02-14 2013-09-06 Sintal S R L Matrice minerale pour formes solides de preparations pour l'administration de substances nutritives et/ou pharmacologiques, utilisation de ladite matrice et procede pour la realiser

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1009134A (en) * 1960-10-17 1965-11-10 Tranatogen Werk Jakob Schwarzk A process for the production of mineral mixture for livestock
FR2987560A3 (fr) * 2012-02-14 2013-09-06 Sintal S R L Matrice minerale pour formes solides de preparations pour l'administration de substances nutritives et/ou pharmacologiques, utilisation de ladite matrice et procede pour la realiser

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
VÁRADYOVÁ Z ET AL: "Effect of silicate minerals (zeolite, bentonite, kaolin, granite) on in vitro fermentation of amorphous cellulose, meadow hay, wheat straw and barley. - PubMed - NCBI", BERLINER UND MÜNCHENER TIERÄRZTLICHE WOCHENSCHRIFT, 1 July 2003 (2003-07-01), pages 317 - 321, XP055221147, Retrieved from the Internet <URL:http://www.ncbi.nlm.nih.gov/pubmed/12894687> [retrieved on 20151015] *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT201800005063A1 (it) * 2018-05-04 2019-11-04 Preparato per prodotti enologici

Also Published As

Publication number Publication date
EP3258915A1 (fr) 2017-12-27

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