WO2016129802A3 - Pkr 저해제를 유효성분으로 포함하는 기관지 천식의 예방 또는 치료용 조성물 - Google Patents

Pkr 저해제를 유효성분으로 포함하는 기관지 천식의 예방 또는 치료용 조성물 Download PDF

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Publication number
WO2016129802A3
WO2016129802A3 PCT/KR2015/013791 KR2015013791W WO2016129802A3 WO 2016129802 A3 WO2016129802 A3 WO 2016129802A3 KR 2015013791 W KR2015013791 W KR 2015013791W WO 2016129802 A3 WO2016129802 A3 WO 2016129802A3
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WO
WIPO (PCT)
Prior art keywords
prevention
treatment
pkr inhibitor
bronchial asthma
composition
Prior art date
Application number
PCT/KR2015/013791
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English (en)
French (fr)
Other versions
WO2016129802A2 (ko
Inventor
이용철
김소리
Original Assignee
전북대학교 산학협력단
전북대학교병원
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 전북대학교 산학협력단, 전북대학교병원 filed Critical 전북대학교 산학협력단
Priority to US15/547,030 priority Critical patent/US10292969B2/en
Priority to GB1712767.1A priority patent/GB2550759B/en
Publication of WO2016129802A2 publication Critical patent/WO2016129802A2/ko
Publication of WO2016129802A3 publication Critical patent/WO2016129802A3/ko

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2200/00—Function of food ingredients
    • A23V2200/30—Foods, ingredients or supplements having a functional effect on health
    • A23V2200/314—Foods, ingredients or supplements having a functional effect on health having an effect on lung or respiratory system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Food Science & Technology (AREA)
  • Nutrition Science (AREA)
  • Polymers & Plastics (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Mycology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

본 발명은 PKR 저해제를 유효성분으로 함유하는 기관지 천식의 예방 또는 치료용 조성물에 관한 것이다. 본 발명에 따른 PKR 저해제 및 이의 유도체는 중성구성 중증 천식 유발 마우스의 기관지 폐포 세척액에서 전체 염증 세포수, 호산구, 중성구 및 림프구의 수를 감소시키고, 기도 염증 정도 및 기도 과민성을 감소시키며, 염증 관련 매개체를 감소시킴으로써, 기관지 천식의 예방, 개선 또는 치료에 유용한 의약품 및 건강기능식품으로 사용될 수 있다.
PCT/KR2015/013791 2015-02-12 2015-12-16 Pkr 저해제를 유효성분으로 포함하는 기관지 천식의 예방 또는 치료용 조성물 WO2016129802A2 (ko)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US15/547,030 US10292969B2 (en) 2015-02-12 2015-12-16 Composition for prevention or treatment of bronchial asthma comprising PKR inhibitor as active ingredient
GB1712767.1A GB2550759B (en) 2015-02-12 2015-12-16 Composition for prevention or treatment of bronchial asthma comprising PKR inhibitor as active ingredient

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020150021423A KR101668074B1 (ko) 2015-02-12 2015-02-12 Ｐｋｒ 저해제를 유효성분으로 포함하는 기관지 천식의 예방 또는 치료용 조성물
KR10-2015-0021423 2015-02-12

Publications (2)

Publication Number Publication Date
WO2016129802A2 WO2016129802A2 (ko) 2016-08-18
WO2016129802A3 true WO2016129802A3 (ko) 2016-10-06

Family

ID=56615649

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2015/013791 WO2016129802A2 (ko) 2015-02-12 2015-12-16 Pkr 저해제를 유효성분으로 포함하는 기관지 천식의 예방 또는 치료용 조성물

Country Status (4)

Country Link
US (1) US10292969B2 (ko)
KR (1) KR101668074B1 (ko)
GB (1) GB2550759B (ko)
WO (1) WO2016129802A2 (ko)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102017799B1 (ko) 2019-03-22 2019-09-03 김성기 천식 완화 또는 치료용 생약 조성물

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20060109360A (ko) * 1998-12-17 2006-10-19 에프. 호프만-라 로슈 아게 4,5-아졸로-옥신돌
WO2009070378A1 (en) * 2007-11-26 2009-06-04 Nestec S.A. Compositions and methods for inhibiting the activation of dsrna-dependent protein kinase and tumor growth inhibition
JP2013545469A (ja) * 2010-12-03 2013-12-26 ビオエンテッヒ・アクチェンゲゼルシャフト 細胞ｒｎａ発現のための方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002081628A2 (en) * 2001-04-05 2002-10-17 Ribozyme Pharmaceuticals, Incorporated Modulation of gene expression associated with inflammation proliferation and neurite outgrowth, using nucleic acid based technologies
CA2631647A1 (en) * 2005-11-30 2007-06-07 Nestec S.A. Use of branched-chain amino acids for the treatment of muscle loss

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20060109360A (ko) * 1998-12-17 2006-10-19 에프. 호프만-라 로슈 아게 4,5-아졸로-옥신돌
WO2009070378A1 (en) * 2007-11-26 2009-06-04 Nestec S.A. Compositions and methods for inhibiting the activation of dsrna-dependent protein kinase and tumor growth inhibition
JP2011504879A (ja) * 2007-11-26 2011-02-17 ネステク ソシエテ アノニム 二本鎖ｒｎａ依存性タンパク質キナーゼの活性化を阻害し腫瘍成長を阻害する組成物及び方法
JP2013545469A (ja) * 2010-12-03 2013-12-26 ビオエンテッヒ・アクチェンゲゼルシャフト 細胞ｒｎａ発現のための方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JAMMI, N. V. ET AL.: "Smali Molecule Inhibitors of the RNA-dependent Protein Kinase", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICAIJONS, vol. 308, 2003, pages 50 - 57, XP004441417 *

Also Published As

Publication number Publication date
KR101668074B1 (ko) 2016-10-21
GB2550759B (en) 2020-11-25
US10292969B2 (en) 2019-05-21
GB201712767D0 (en) 2017-09-20
WO2016129802A2 (ko) 2016-08-18
GB2550759A (en) 2017-11-29
US20180000794A1 (en) 2018-01-04
KR20160099756A (ko) 2016-08-23

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