WO2016078032A1 - 一种具有缓解酸痛功能的多种天然植物萃取液混合制剂及制备方法 - Google Patents

一种具有缓解酸痛功能的多种天然植物萃取液混合制剂及制备方法 Download PDF

Info

Publication number
WO2016078032A1
WO2016078032A1 PCT/CN2014/091612 CN2014091612W WO2016078032A1 WO 2016078032 A1 WO2016078032 A1 WO 2016078032A1 CN 2014091612 W CN2014091612 W CN 2014091612W WO 2016078032 A1 WO2016078032 A1 WO 2016078032A1
Authority
WO
WIPO (PCT)
Prior art keywords
extract
mixed
preparation
soreness
natural plant
Prior art date
Application number
PCT/CN2014/091612
Other languages
English (en)
French (fr)
Inventor
杨武松
Original Assignee
杨武松
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 杨武松 filed Critical 杨武松
Priority to PCT/CN2014/091612 priority Critical patent/WO2016078032A1/zh
Priority to CN201480001294.8A priority patent/CN105813647A/zh
Publication of WO2016078032A1 publication Critical patent/WO2016078032A1/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender

Definitions

  • the present invention relates to a transdermal absorption agent having a soreness-relieving function and a preparation method thereof.
  • Western medicine in the case of headache or other body pain symptoms, is given a nerve blocker, blocking the pain, allowing patients to reduce the impact of headache, but caused by liver and kidney Very large injuries, and frequent cases of patients using improper painkillers to produce blasting hepatitis and kidney necrosis leading to life-long dialysis. Muscles or joints are sore. Western medicine often gives muscle relaxants, but muscle relaxants are often accompanied by lethargy, occasional spatial confusion, and severe respiratory failure.
  • a healthy human body means that all systems in the body's digestive system, respiratory system, circulatory system, immune system, reproductive system, and nervous system are in a healthy state.
  • any system is in a healthy state, it means that all relevant organs in the system are in a healthy state.
  • the relevant tissues in the organ are in A healthy state.
  • any organization is in a healthy state, it means that all relevant cells in the tissue are in a healthy state.
  • any one cell is in a healthy state, it means that all kinds of cell activities of the cell are proceeding normally.
  • Normal cellular activities involve internal activities such as intracellular protein synthesis, replication, function, apoptosis, and the normal function of extracellular substances entering cells, and the activities of substances in the cells after metabolism, such as substance clearance and excretion, must be in a healthy state.
  • the trajectory works normally.
  • Each cell of the human body contains about 8 billion proteins, and the human body contains about 60 trillion cells. Except for individual cells, they have normal and fixed cell activities, and each cell also has an associated interaction activity. Therefore, in the small universe of the human body, maintaining the cellular activity (or most of the cells) of each cell in a normally fixed dynamic and static state is a very complicated and huge mechanism supported.
  • the life program password set by DNA - detect the environment and lead the plant strain to breed, stop, apopate and other life activities according to different environments.
  • Energy group Set the energy caused by visible substances as positive energy. In traditional Chinese medicine, it is “hot”, such as lychee, longan, and beef. The energy caused by setting invisible substances is negative energy. In traditional Chinese medicine, it is “cold”, such as watermelon and fairy grass. We set the plant to contain both visible and invisible substances.
  • the cell activity at the site of the sore lesion is abnormal.
  • the amino acid group - that is, the cell cannot be synthesized enough / correct / effective And essential amino acid groups; various essential enzymes - cells cannot synthesize the enzymes, or extracellular enzymes cannot be brought into the cells; energy groups - intracellular There are not enough and necessary different energy groups to support the normal activities of the cells; after about 20 years of research, the inventors found that different plants carry different amino acids/different enzymes and different energies. When the components of these plants disintegrate in the human body, those amino acids/enzymes and energy are released under the guidance of the plant's own DNA code.
  • the common phenomenon of these cell populations is that amino acids cannot be correctly combined into the correct peptide chain, and even if they are combined into a normal peptide chain, the correct ratio of folding into a normal 3D state protein is low.
  • the reason is that the energy condition is mutated, causing the positive energy of the lesion to be too high (the definition of TCM is called dry heat), which causes the overall environmental variability.
  • these cell populations need components that carry more negative energy (Traditional Chinese medicine is the botanical component of the attribute cold).
  • negative energy is released inside and outside the cell, the enzyme group/amino acid group and cells contained in the plant.
  • the contained enzyme group and amino acid group will produce a similar "matching" effect, that is, to guide the correct synthesis of the peptide chain, and to make the correct 3D folding into the correct protein, that is, the various healthy proteins in the cell can Properly synthesize and function properly as they should.
  • the ultimate phenomenon is to guide the normalization of cellular activities.
  • the inventor's research is to find out the corresponding rules for the cell and plant characteristics of sore lesions, and then make these plants into products.
  • cell activity is the various reactions carried out inside the cell. Any reaction will be affected by the overall environment of the surrounding area. When the energy inside or around the cell and the conditions required for the reaction change due to intrinsic or extrinsic factors, the intracellular reaction produces hysteresis or abnormality, that is, abnormal cell activity occurs.
  • the inventors attempted to extract a specific combination of natural plants, extract the "combination components" we need, and then through a specially designed processing procedure, the mixed solution carries a certain total environmental regulatory factor group and performs cell activities.
  • the desired group of elements to relieve or eliminate sore spots in the body.
  • the present invention provides a mixture of various natural plant extracts having a soreness-reducing function, the plurality of natural plant extract mixed preparations comprising:
  • the first large carp extract accounting for 28-32% of the mixed preparation.
  • the first Compositae extract accounts for 23-27% of the mixed preparation.
  • the micro-lipids of the various natural plant extracts and oils are applied to the skin, the micro-lipids are directly introduced into the tissues and cells of the affected part by direct transdermal absorption technology to change the overall environment of the affected part.
  • the activity of the affected part of the cells can be carried out normally, that is, the abnormal cell and tissue activities are quickly guided, and the purpose of eliminating the disease or the cause is achieved.
  • our products of the invention can gradually eliminate the symptoms and causes after repeated use.
  • the invention has the following methods for obtaining a mixture of various natural plant extracts for relieving soreness, for example, the following three steps:
  • the extract is a single plant, namely, a scorpion extract, a lip-shaped extract, a first large scorpion extract, a first compositae extract, etc., each of which takes 15 kg of the plant body and Chopped, Each plant body is fresh, that is, within 12 hours of harvesting or within 5 hours of harvesting within 5-7 degrees Celsius, adding 28 liters of pure water and 2.0 liters of alcohol, respectively, to warm up to smoldering Boiling at 100 degrees Celsius, and then maintaining the boiling state for 30 minutes, the extract and the plant residue are separated by a centrifuge. After the plant extract is naturally cooled, it is filtered by fine mesh, and the filtered plant extract is stored in a refrigerator. , the temperature of the refrigerator is maintained at 5 ⁇ 1 ° C, becoming each extract;
  • the extract of the genus Branch is 13-17%, the best is 15%; the lip-shaped extract accounts for 18-22% of the mixed preparation, the best is 20%; the first large ⁇ Branch extract, accounting for 28-32% of the mixed preparation, preferably 30%; and the first Compositae extract, accounting for 23-27% of the mixed preparation, optimally 25%, and become an extract mixture.
  • the genus Polygonaceae contains a variety of amino acids and alkaloids, which have the effects of clearing away heat and detoxifying, cooling blood and stopping bleeding.
  • the plants of the Labiatae family have the functions of bactericidal, anti-caries, pass-through and sweating agents.
  • the plants of the family Polygonaceae have swelling and dehydration. The efficacy of the Compositae can reduce inflammation and quickly relieve pain.
  • a mixed preparation can be prepared.
  • a soaking method is adopted, that is, the affected part is immersed in the mixed preparation, and the anti-inflammatory, swelling and tissue repair can be obtained. The effect.
  • the extract of the genus Polygonaceae is preferably a wild leeks extract made from wild leeks, a lip-shaped extract, preferably a celery extract prepared from celery, the first large genus
  • the extract is a large fly grass extract prepared by using large flying grass
  • the first compositae extract is preferably a sorghum extract prepared by using red sorghum.
  • a mixed preparation can be prepared.
  • a soaking method is adopted, that is, the affected part is immersed in the mixed preparation, and the anti-inflammatory, swelling and tissue repair can be obtained. The effect is more obvious.
  • the above mixed preparation further comprises a second large genus extract, which accounts for 13-17% of the mass of the mixed preparation, preferably 15%; and the second compositae extract accounts for the mixed preparation.
  • the second largest extract of the family is the small flying grass extract
  • the second extract of the compositae is the extract of the salty grass, the effect is excellent. As shown in Table 1.
  • the dosage of the above preparation is uniformly used in kilograms or grams, which is a comparative value.
  • 15% of the lip-shaped extracts of the above-mentioned genus extracts accounted for the mass ratio of the mixed preparations, accounting for 20% of the mass ratio of the mixed preparations, and the first large extract of the genus , accounting for 30% of the mass ratio of the mixed preparation, and the first Compositae extract, which accounts for 25% of the mass ratio of the mixed preparation, that is, 15 kg + 25 kg + 30 kg + 25 kg or 15 g + 25 g + 30 g + 25 grams, according to the amount of demand and contrast value adjustment.
  • the mixed preparation further comprises the second large scorpion extract, which accounts for 15% of the mass ratio of the mixed preparation; and the second compositae extract accounts for 10% of the mass ratio of the mixed preparation, that is, 15 kg + 25 kg + 30 kg +25 kg +15 kg +10 kg or 15 g +25 g +30 g +25 g +15 g +10 g, according to the amount of demand and the contrast value adjustment.
  • the extract mixture and the oil obtained by mixing the above various plant extracts are placed in a low-speed stirring tank at a mass ratio of 97:3, and stirred, and uniformly used in kilograms or grams, which is a comparative value, 97 of which is 97:3 is the aforementioned
  • the extract of the genus Branches accounts for 15% of the lip-form extracts of the mixed preparations, accounting for 20% of the mass ratio of the mixed preparations.
  • the first large extract of the genus Polygonaceae accounts for 30% of the mass ratio of the mixed preparations, and the first Compositae extract
  • the liquid, which accounts for 25% of the mass ratio of the mixed preparation is 15 kg + 25 kg + 30 kg + 25 kg or 15 g + 25 g + 30 g + 25 g, or the aforementioned extract of the family Branch accounts for 15% of the lip of the mixed preparation Branch extract, accounting for 20% of the mixed preparation, the first large extract of the family, accounting for 30% of the mixed preparation, and the first Compositae extract, accounting for 25% of the mixed preparation, and the second largest extract of the family , accounting for 15% of the mixed preparation; and the second Compositae extract, accounting for 10% of the mixed preparation, ie It is 15 kg +25 kg +30 kg +25 kg +15 kg +10 kg or 15 g +25 g +30 g +25 g +15 g +10 g, according to the ratio and the contrast value.
  • the oil contains 6.0-7.0% of glycerin, 3.0-3.5% of wintergreen oil, 1.0-2.0% of peppermint oil, and 0.025-0.035% of animal fat which does not contain pigs.
  • the oil and fat are mixed with kilograms or grams of mixed preparation, which is a comparison value. That is, when the mixed preparation is in comparison with kilograms, the fat is also in comparison with kilograms, and each mass fraction is based on the total mass of the grease.
  • the stirring time is one minute, the stirring speed is 300 rpm, and then enters a high-pressure homogenizing emulsifier to make the mixed preparation and the oil particle size reach 0.1 ⁇ m - 2 ⁇ m, so that the mixed preparation can finally become a Riceified liposome.
  • the container uses a plastic and glass container such as a commercially available ointment or a cosmetic maintenance lotion, and the unit is indicated. Mml ml.
  • the use method and effect according to the size of the affected area, take 2 ⁇ 5ml, evenly spread on the affected part and gently rub back and forth to the micro-dry with the palm, then take about 1.5ml of the product, rubbing to the micro-dry with the above. (After the above-mentioned operation, the affected part is evenly coated with about 1 to 2 ml of the product, and the kitchen PE is covered with a plastic wrap for 1 to 2 hours). Use 3 to 4 times a day according to the above usage.
  • dysmenorrhea implementation time: 1st Oct. 2003 ⁇ 30th Sep.2007, implementation location: Taiwan, the United States, use: 3 to 4 times to take the product about 7 ⁇ 8ml evenly coated Spread on the lower abdomen, rub gently with the palm to the micro-dry. Use 3 to 4 times a day. After the original dysmenorrhea patients use 1 to 2 times, the menstrual cycle has a great chance of no longer dysmenorrhea. After using this product, patients with dysmenorrhea may not completely eliminate dysmenorrhea, but it can reduce the pain. Use this product before the onset of blood, have the opportunity to prevent the occurrence of dysmenorrhea or reduce the pain.
  • the invention does not contain western medicine (i.e., a nerve blocker). Therefore, the progress of the present invention is: 1.
  • the main component is made of natural non-medicinal plants; 2. External use; 3. Direct transdermal absorption, rapid effect; 4. No side effects, no damage to the internal organs; 5. Nanocrystallization High-tech processing processes such as micro-lipids; 6. No harmful substances are emitted at all during the production process.
  • cure means that the symptoms of soreness are completely relieved, and no recurrence occurs within 15 days of discontinuation of the product.
  • Any patient who suffers from soreness caused by bone dislocation may have to have a chance to cure the sore symptoms after correction of the orthopedic position.
  • This table "produces dysmenorrhea” is diagnosed by a physician as 13 consecutive patients.

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Dispersion Chemistry (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

一种具有缓解酸痛功能的多种天然植物萃取液混合制剂及其制法，该制剂包含：苋科萃取液13-17％，如野苋菜；唇形科萃取液18-22％，如仙草；第一大戟科萃取液28-32％，如大飞扬草；及第一菊科萃取液23-27％，如胜红蓟。该制剂的制法包含：将上述萃取液与油脂搅拌，将搅拌后的混合液在高压下均质乳化。

Description

一种具有缓解酸痛功能的多种天然植物萃取液混合制剂及制备方法 技术领域
本发明涉及一种具有缓解酸痛功能的经皮吸收药剂及其制备方法。
背景技术
在目前西医与中医治疗实务中，举例来说，西医在头痛或其他身体疼痛症状时，给予的是神经阻断剂，阻断了痛觉，让患者减少头痛产生的影响，但是对肝与肾造成非常大的伤害，也经常发生患者不当使用止痛药产生猛爆型肝炎与肾脏坏死导致终生洗肾的案例。肌肉或关节痠痛，西医经常给予患者肌肉松弛剂，但是肌肉松弛剂经常伴随的是嗜睡、偶发性空间迷向，严重可能导致呼吸衰竭。
中医药品分为上药、中药与下药，治疗疾病的下药，不论其副作用多小的药材也都具有毒性的问题，长期服用也会产生内脏器官损伤。
而且，不论是中药或西药，很多给药的方式都采用口服，经肠胃道吸收，转为血液传送，血液传送的概念是血液当中维持一定的药剂量，并维持药剂量在血液中有一定浓度，但这一定的血液浓度，除了作用在患部外，也会作用在身体其他部位，这些具有一定毒性的治疗药物同时作用在身体的各处，对于身体细胞造成的破坏，因此，在以血液浓度药物治疗期间，造成的身体其他各处副作用的状况，也就不足为奇了。
于是，发明人在上述的背景之下，整理出以下的理论基础：
1、健康的人体，表示体内消化系统、呼吸系统、循环系统、免疫系统、生殖系统、神经系统等所有的系统均处在一个健康的状态。任何一个系统处在健康状态时，表示该系统内的所有相关的器官均处在健康的状态。任何一个器官处在健康状态时，表示该器官内相关的组织均处在 一个健康的状态。任何一个组织处在健康状态时，表示该组织内的所有相关细胞均处在健康的状态。任何一个细胞处在健康状态时，表示该细胞的所有各种细胞活动均正常的进行着。正常的细胞活动，涉及细胞内蛋白质的合成、复制、功能、凋亡等内部活动，以及细胞外物质进入细胞的正常功能，细胞内部代谢后物质清除、排出细胞外等活动，都必须在一个健康的轨迹上正常进行。
2、人体的每一个细胞约含有80亿个的蛋白质，而人体含有约60兆个细胞，除了个别单一细胞均有其正常、固定的细胞活动，各个细胞之间也有关联性的交互影响活动。因此，在人体内的小宇宙，要维持每一个细胞的细胞活动(或绝大部分的细胞)在正常固定的动态和静态状态是一个非常复杂而且有着庞大的机制在支撑着。
3、在药物开发的经验里，我们经常发现某些成分在体外单株体杀灭试验时成功率非常高，但当进入动物试验或人体试验时，成功率却非常的低。为什么？因为诚如前述，人体细胞活动的复杂性、庞大性已非单一因素或少数因素能够去完全控制或影响，此种存在着的庞大复杂性，我们把它叫做“体内总体环境”。也就是说，体内总体环境不易被外在的单一或少数因子所完全控制。如众多癌症药物的开发就是一个鲜明的例子。因此，秉承着人体是大自然所创造的理念，我们尝试从大自然里去寻找此等能明显影响“体内总体环境”的天然因子群。
4、我们观察到一些植物在寒带、温带、热带等不同环境均能正常繁衍，有些植物在冷热交替或干湿交替环境中均能正常生长，也有些植物只生长在固定季节，生长季节过去时，株体就自然止息或凋亡，但隔年生长季节来临时又重新生长。因此，我们发现在这些植物的株体内，除了含有现代科技可以分析出来的成分，还隐藏着现代科技尚未检测出来的“因子群”。此等“因子群”对环境的变化中主导或影响植物的生长、繁衍、 止息或凋亡，也就是这些“因子群”具有高度的调节植物株体去适应环境的能力。
5、“因子群”是什么？我们发现它们是：
1.)氨基酸群－细胞结构的基本原料供应。
2.)各种不同的酶－蛋白质合成、分解、代谢等细胞活动的催化剂。
3.)不同的能量群。
4.)DNA所设定的生命程序密码－侦测环境并主导植物株体依不同环境进行繁衍、止息、凋亡等生命活动。
5.)其他未明的成份交互作用机制。
6.)以上因素的交互影响。
能量群：设定可见物质所造成的能量为正向能量，在传统中医里性属“躁热”，如荔枝、龙眼、牛肉等。设定不可见物质所造成的能量为负向能量，在传统中医里性属“寒”，如西瓜、仙草等。我们设定植物株体内同时含有可见物质及不可见物质。
6、由于人体的细胞活动影响因子极其复杂，而且疾病的机制也十分复杂。因此，我们尝试去寻找一个“总体解决方法”(Total Solution)，去取代传统对单一因子或少数因子对疾病影响的研究。也就是尝试从具有不同特性的植物中，去寻求一个“组合成分”，此种“组合成份”中含有足够的“因子群”，再把此种“组合成分”输送到患部组织的细胞内，达到导引细胞活动正常化的目的。当所有或绝大部分患部的细胞活动正常化时，疾病的现象或原因自然消除。
7、而对于产生酸痛病灶部位的细胞活动是不正常的，于酸痛部位的细胞，我们找出来影响细胞活动不正常的因子群为：氨基酸群－即细胞内无法合成足够的/正确的/有效的且必须的氨基酸群；各种必须的酶－细胞无法合成该有的酶，或细胞外的酶无法带入细胞内；能量群－细胞内 没有足够且必须的不同能量群，去支撑细胞的正常活动；发明人经过约20年的研究，发现不同的植物带有不同的氨基酸/不同的酶和不同的能量。当这些植物的成份在人体内崩解的过程中，在植物本身DNA密码的导引下，会释放出那些氨基酸/酶和能量。以酸痛部位的细胞状况，这些细胞群的共同现象是氨基酸无法正确结合成正确的肽链，而且即使结合成正常的肽链，其折叠成正常的3D状态蛋白质的正确性比例偏低，究其原因，就是能量条件产生变异，造成病灶部位正向能量太高(中医的定义叫性燥热)，造成了整体环境变异。
因此，这些细胞群需要的是携带更多负向能量的成份(中医意义为属性寒的植物成份)，当这些负向能量被释放在细胞内外同时，植物所含的酶群/氨基酸群和细胞内含的酶群及氨基酸群会产生类似“配套”的效应，即去导引肽链的正确合成，以及做正确的3D折叠成为正确的蛋白质，也就是说，细胞内各种健康的蛋白质能正确的合成而且正常的发挥它们应有的功能。其最终的现象，就是引导细胞活动的正常化。发明人的研究，就是找出酸痛病灶的细胞和植物特性的对应规则，再把这些植物做成产品。
由于，人体内的每一个细胞，就好像是一座庞大的工厂，细胞活动就是细胞内所进行的各种反应。任何反应，均会受到周边总体环境的影响。当细胞内部或周边的能量及反应所需条件因内在或外在因素而改变时，细胞内的反应即产生迟滞或异常，亦即产生了不正常的细胞活动。
为此，本发明人试图取用特定的天然植物组合，萃取出我们所需要的“组合成分”，再经过特殊设计的加工程序，使此混合溶液携带一定的总体环境调节因子群及进行细胞活动所需的元素群，从而缓解或消除身体部位的酸痛病灶。
发明内容
为了解决上述技术问题，本发明提供了一种具有缓解酸痛功能的多种天然植物萃取液混合制剂，所述多种天然植物萃取液混合制剂包含：
笕科萃取液，占混合制剂比13-17％；及
唇形科萃取液，占混合制剂比18-22％；及
第一大戟科萃取液，占混合制剂比28-32％；及
第一菊科萃取液，占混合制剂比23-27％。
上述制剂的制备过程中，按照所述多种天然植物萃取液的混合物：油脂＝97：3的质量比例配比，然后搅拌混合均匀后，再加入到高压均质乳化机中，同步完成奈米化及微脂体制作。
所述多种天然植物萃取液与油脂纳米和微脂体化后，再于皮肤外涂抹，利用直接经皮吸收科技，将上述微脂体直接带入患部组织及细胞内，改变患部的总体环境条件，使患部细胞内的活动得以正常进行，亦即迅速导正不正常的细胞与组织活动，达到消除病症或病因的目的。对于严重的症状，经过重复使用我们所本发明产品也能逐渐消除病症及病因。
具体实施方式
为了方便理解，以下仅为本发明的一个较佳实施例，不应作为对本发明可实施范围的限制。
本发明具有缓解酸痛功能的多种天然植物萃取液混合物的获得方法，例如可以是以下3个步骤：
(1)、取笕科萃取液，占混合制剂比13-17％，最佳为15％；及唇形科萃取液，占混合制剂比18-22％，最佳为20％；及第一大戟科萃取液，占混合制剂比28-32％，最佳为30％；及第一菊科萃取液，占混合制剂比23-27％，最佳为25％；
(2)、其萃取液为将各单一植物，即笕科萃取液、唇科形萃取液、第一大戟科萃取液、第一菊科萃取液等，各取其植物株体15千克并切碎， 每个植物株体都是采用新鲜的，即采收12小时内的或采收七小时以内即进入摄氏度5-7度内，分别加入纯水28升及酒精2.0升混合，以猛火加温至沸腾100摄氏度，再以温火维持沸腾状态30分钟后，以离心机分离萃取液及植物残渣，待植物萃取液自然冷却后以细网过滤之，过滤后的植物萃取液置于冷藏库保存备用，冷藏库温度维持在5±1℃之间，成为各萃取液；
(3)、然后依笕科萃取液占混合制剂比13-17％，最佳为15％；唇科形萃取液，占混合制剂比18-22％，最佳为20％；第一大戟科萃取液，占混合制剂比28-32％，最佳为30％；及第一菊科萃取液，占混合制剂比23-27％，最佳为25％，而成为萃取液混合物。
笕科植物含有多种氨基酸、生物碱，具有清热解毒，凉血止血的功效，唇形科植物有杀菌、抗痉挛、通经、发汗剂的功效，大戟科植物有消肿与消积水的功效，菊科植物可以减轻发炎症并迅速止痛。
如此，依照前述比例，即可制成混合制剂，对于手部与足部的一般挫伤与运动伤害，采用浸泡法，即将患部浸泡于混合制剂中，就可以得到消炎、消肿与组织逐部修复的功效。
而当笕科萃取液，较佳的是采用野苋菜而制成的野苋菜萃取液，唇科形萃取液，较佳的是采用仙草而制成的仙草萃取液，第一大戟科萃取液较佳的是采用大飞扬草而制成的大飞扬草萃取液，第一菊科萃取液，较佳的是采用胜红蓟而制成的胜红蓟萃取液。
如此，依照前述比例，即可制成混合制剂，对于手部与足部的一般挫伤与运动伤害，采用浸泡法，即将患部浸泡于混合制剂中，就可以得到消炎、消肿与组织逐部修复的功效，更加明显。
其中，进一步的，上述混合制剂更包含了第二大戟科萃取液，占混合制剂质量的13-17％，最佳为15％；及第二菊科萃取液，占混合制剂质 量的8-12％，最佳为10％，其第二大戟科萃取液为小飞扬草萃取液，第二菊科萃取液为咸丰草萃取液时，功效卓越。如表一。
上述制剂剂量，统一用千克或克，为对比值，如前述笕科萃取液占混合制剂质量比的15％唇科形萃取液，占混合制剂质量比的20％，第一大戟科萃取液，占混合制剂质量比的30％，及第一菊科萃取液，占混合制剂质量比的25％，即为15千克+25千克+30千克+25千克或15克+25克+30克+25克，依照需求量按其比例与对比值调剂。当混合制剂更包含了第二大戟科萃取液，占混合制剂质量比的15％；及第二菊科萃取液，占混合制剂质量比的10％，即为15千克+25千克+30千克+25千克+15千克+10千克或15克+25克+30克+25克+15克+10克，依照需求量按其比例与对比值调剂。
另外，由于很多的酸痛是产生在身体处，如痛风、痛经、头痛、肩颈痛、腰背痛等，若采用上述的多种植物萃取液组成的混合制剂直接以浸泡法治疗酸痛部位，虽然可行，但是不符成本亦过于浪费，于是发明人加入油脂，并加入奈米化制成，使其混合制剂最终可以成为已奈米化的微脂体，制程如下：
由上述多种植物萃取液混合得到的萃取液混合物与油脂，以97:3的质量比例置入低速搅拌桶中进行搅拌，统一用千克或克，为对比值，其97:3的97为前述笕科萃取液占混合制剂质量比的15％唇科形萃取液，占混合制剂质量比的20％，第一大戟科萃取液，占混合制剂质量比的30％，及第一菊科萃取液，占混合制剂质量比的25％，即为15千克+25千克+30千克+25千克或15克+25克+30克+25克，或前述笕科萃取液占混合制剂比15％唇科形萃取液，占混合制剂比20％，第一大戟科萃取液，占混合制剂比30％，及第一菊科萃取液，占混合制剂比25％，及第二大戟科萃取液，占混合制剂比15％；及第二菊科萃取液，占混合制剂比10％，即 为15千克+25千克+30千克+25千克+15千克+10千克或15克+25克+30克+25克+15克+10克，依照需求量按其比例与对比值调剂。油脂包含甘油6.0～7.0％，及冬青油3.0～3.5％，及薄荷油1.0～2.0％，及不包含猪的动物油脂0.025-0.035％，油脂同混合制剂统一用千克或克，为对比值，即当混合制剂为千克为对比值，油脂亦以千克为对比值，各质量分数以油脂总质量为基准。
低速搅拌桶搅拌，该搅拌时间为一分钟，搅拌转速每分钟转速300转，后进入高压均质乳化机使其混合制剂与油脂粒径达到0.1μm-2μm，使其混合制剂最终可以成为已奈米化的微脂体。
而成为已纳米化的微脂体的混合制剂，或混合制剂，为了运送及销售，以及使用者便利性，其容器使用如市售药膏或化妆保养乳液所使用之塑胶及玻璃容器，标示单位为毫升ml。
如表二，使用法与功效：依患部面积大小，取2～5ml，均匀涂布于患部并以手掌轻轻来回摩擦至微干，再取约1.5ml产品，同上述摩擦至微干。(重症者如上述动作后，再把患部以产品约1～2ml涂布均匀后，加上厨房用PE保鲜膜覆盖1～2小时)。每天依上述用法使用3～4回。
如表三、表四、表五，用于痛风方面：实施时间:1st Oct.2003～30thSep.2007，实施地点:台湾、美国，使用方法：即将发作前：患部出现紧绷不适感，取产品约3ml，均匀涂布于患部并以手掌轻摩擦至微干，再取约1.5ml同上述摩擦至微干。(重症病史患者如上述动作后，再把患部以产品约1～2ml涂布均匀后加上厨房用PE保鲜膜覆盖1～2小时。症状已发生者：症状较轻时如上处置。症状严重者视患部面积大小取产品2～5ml均匀轻涂布于患部后，加上厨房用PE保鲜膜覆盖2～3小时。每天依上述用法使用3～4回。
如表六、表七，用于痛经方面：实施时间：1st Oct.2003～30th Sep.2007，实施地点：台湾、美国，使用方法：分3～4次取用产品约7～8ml均匀涂 布于小腹，以手掌轻摩擦至微干。每天使用次数3～4回。原发型痛经患者使用1～2回后，该月经周期有很大的机会不再痛经。续发型痛经患者使用本产品后，有可能无法完全消除痛经，但可以降低痛感。经血来临前使用本产品，有机会防止痛经的发生或降低疼痛感。
如表八，用于退化性关节炎方面，实施时间：1st Oct.2003～30th Sep.2007，实施地点：台湾、美国，使用方法：依患部关节部位面积大小，取用产品3～6ml分次均匀涂布于患部，并以手掌轻摩擦至微干。再取约2～3ml产品，同上述摩擦至微干。(重症者如上述动作后，再把患部以产品约2～3ml涂布均匀后，加上厨房用PE保鲜膜覆盖2～3小时)。每天依上述用法使用3～4回。
由于，本发明不含西药(即神经阻断剂证明)。因此，本发明进步性共有：1、主成份采用天然非药用植物为原料；2、外用；3、直接经皮吸收，效果迅速；4、无副作用，不伤害内脏；5、经奈米化、微脂体等高科技加工制程；6、生产过程中完全不排放任何有害物质。
表一：挫伤患者使用记录
Figure PCTCN2014091612-appb-000001
表二：一般酸痛患者使用记录
Figure PCTCN2014091612-appb-000002
Figure PCTCN2014091612-appb-000003
说明：上列“缓解”意谓酸痛症状明显舒缓或解除。
说明：(1)表二的患者与表一相同，取能有效追踪个案进行统计。
(2)上表“无全效”患者，表示或有缓解，但无法完全治愈。
(3)上列“治愈”意谓酸痛症状完全解除，且在停用产品15天内不复发作。
(4)上表除头痛及偏头痛外，患者均被要求至少连续使用三天，至症状解除即停用。
(5)凡因骨骼错位造成压迫引起酸痛的患者，必须经骨骼正位矫正后，才有机会根治酸痛症状。
表三：痛风患者前兆产生即使用本产品
Figure PCTCN2014091612-appb-000004
表四：前表“发作”者的症状与其往例症状比较
Figure PCTCN2014091612-appb-000005
表五：痛风患者发作后再施用本产品疗效记录
Figure PCTCN2014091612-appb-000006
说明:无全效表示或有缓解，但无法完全治愈。
表六：女性经期开始产生疼痛后使用记录
Figure PCTCN2014091612-appb-000007
说明：(1)14人无全效者经医师诊断发现其中11人均为续发性患者，需就医。
(2)无全效表示或有缓解，但无法完全消除疼痛。
表七：女性经期即将开始前使用记录
Figure PCTCN2014091612-appb-000008
说明：(1)本表病例均为长期痛经患者。
(2)本表“产生痛经”者经医师诊断13人为续发性患者。
(3)表一及表二参与试验的患者群不相同
表八退化性关节炎疗效记录
Figure PCTCN2014091612-appb-000009

Claims (21)

  1. 一种具有缓解酸痛功能的多种天然植物萃取液混合制剂，所述多种天然植物萃取液混合制剂包含：
    笕科萃取液，占混合制剂比13-17％；及
    唇形科萃取液，占混合制剂比18-22％；及
    第一大戟科萃取液，占混合制剂比28-32％；及
    第一菊科萃取液，占混合制剂比23-27％。
  2. 根据权利要求1所述的具有缓解酸痛功能的多种天然植物萃取液混合制剂，其特征是，该萃取液是将各单一植物取植物株体切碎，其中每15千克植物株体加入纯水28升及酒精2.0升混合，以猛火加温至沸腾100摄氏度，再以温火维持沸腾状态30分钟后，以离心机分离萃取液及植物残渣，待植物萃取液自然冷却后以细网过滤之，过滤后的植物萃取液置于冷藏库保存备用，冷藏库温度维持在5±1℃之间。
  3. 根据权利要求1所述的具有缓解酸痛功能的多种天然植物萃取液混合制剂，其特征是，该笕科萃取液为野苋菜萃取液。
  4. 根据权利要求1所述的具有缓解酸痛功能的多种天然植物萃取液混合制剂，其特征是，该唇形科萃取液为仙草萃取液。
  5. 根据权利要求1所述的具有缓解酸痛功能的多种天然植物萃取液混合制剂，其特征是，该第一大戟科萃取液为大飞扬草萃取液。
  6. 根据权利要求1所述的缓解酸痛的多种天然植物萃取液混合制剂，其特征是，该第一菊科萃取液为胜红蓟。
  7. 根据权利要求1所述的具有缓解酸痛功能的多种天然植物萃取液混合制剂，其特征是，更包含了第二大戟科萃取液，占混合制剂比13-17％；及第二菊科萃取液，占混合制剂比8-12％。
  8. 根据权利要求7所述的具有缓解酸痛功能的多种天然植物萃取液混合制剂，其特征是，该第二大戟科萃取液为小飞扬草萃取液。
  9. 根据权利要求7所述的具有缓解酸痛功能的多种天然植物萃取 液混合制剂，其特征是，该第二菊科萃取液为咸丰草萃取液。
  10. 根据权利要求1所述的具有缓解酸痛功能的多种天然植物萃取液混合制剂，其特征是，其中笕科萃取液占混合制剂质量比15％。
  11. 根据权利要求1所述的具有缓解酸痛功能的多种天然植物萃取液混合制剂，其特征是，其中唇形科萃取液占混合制剂质量比20％。
  12. 根据权利要求1所述的具有缓解酸痛功能的多种天然植物萃取液混合制剂，其特征是，其中第一大戟科萃取液占混合制剂质量比30％。
  13. 根据权利要求1所述的具有缓解酸痛功能的多种天然植物萃取液混合制剂，其特征是，其中第一菊科萃取液占混合制剂质量比25％。
  14. 根据权利要求1所述的具有缓解酸痛功能的多种天然植物萃取液混合制剂，其特征是，其中更包含了第二大戟科萃取液，其占混合制剂比15％；以及第二菊科萃取液，占混合制剂比10％。
  15. 一种具有缓解酸痛功能的多种天然植物萃取液混合制剂的制备方法，其包括以下步骤：
    步骤1：取笕科萃取液，该笕科萃取液为野苋菜萃取液，占混合制剂比15％；及唇形科萃取液，唇形科萃取液为仙草萃取液，占混合制剂比20％；及
    第一大戟科萃取液，第一大戟科萃取液为大飞扬草萃取液，占混合制剂比30％；及
    第一菊科萃取液，第一菊科萃取液为胜红蓟，占混合制剂比25％；
    步骤2：将各单一植物取植物株体15千克并切碎，加入纯水28升及酒精2.0升混合，以猛火加温至沸腾100摄氏度，再以温火维持沸腾状态30分钟后，以离心机分离萃取液及植物残渣，待植物萃取液自然冷却后以细网过滤，过滤后的植物萃取液置于冷藏库保存备用，冷藏库温 度维持在5±1℃之间；
    步骤3：将上述萃取液混合后与油脂以97:3的质量比例置入低速搅拌桶中进行搅拌，搅拌后的混合液注入高压均质乳化机中，同步完成奈米化及微脂体制作。
  16. 根据权利要求15所述的具有缓解酸痛功能的多种天然植物萃取液混合制剂的制备方法，其特征是，该油脂包含甘油6.0～7.0％、冬青油3.0～3.5％、薄荷油1.0～2.0％及不包含猪的动物油脂0.025-0.035％，各质量分数以油脂总质量为基准。
  17. 根据权利要求15所述的具有缓解酸痛功能的多种天然植物萃取液混合制剂的制备方法，其特征是，该搅拌时间为一分钟，搅拌转速每分钟转速300转。
  18. 根据权利要求15所述的具有缓解酸痛功能的多种天然植物萃取液混合制剂的制备方法，其特征是，该奈米化及微脂体制作，是通过高压均质乳化机使所述多种天然植物萃取液与油脂粒径达到0.1μm-2μm。
  19. 根据权利要求15所述的具有缓解酸痛功能的多种天然植物萃取液混合制剂的制备方法，其特征是，在向所述萃取液加入油脂前，即介于步骤2和3之间，更包含了向所述萃取液混合物加入第二大戟科小飞扬草萃取液、以及第二菊科咸豊草萃取液的步骤，其中所述第二大戟科小飞扬草萃取液占混合制剂质量比为15％，第二菊科咸豊草萃取液占混合制剂质量比10％。
  20. 根据权利要求15所述的具有缓解酸痛功能的多种天然植物萃取液混合制剂的制备方法，其包括以下步骤：
    步骤1：取笕科萃取液，该笕科萃取液为野苋菜萃取液，占混合制剂质量比15％；及
    唇形科萃取液，唇形科萃取液为仙草萃取液，占混合制剂质量比20％；及
    第一大戟科萃取液，第一大戟科萃取液为大飞扬草萃取液，占混合制剂质量比30％；及
    第一菊科萃取液，第一菊科萃取液为胜红蓟，占混合制剂质量比25％；
    步骤2：将各单一植物取植物株体15公斤并切碎，加入纯水28公升及酒精2.0公升混合，以大火加温至沸腾100摄氏度，再以温火维持沸腾状态30分钟后，以离心机分离萃取液及植物残渣，待植物萃取液自然冷却后以细网过滤之，过滤后的植物萃取液置于冷藏库保存备用，冷藏库温度维持在5±1℃之间；
    步骤3：将上述萃取液混合后与油脂以97:3的质量比置入低速搅拌桶中进行搅拌，搅拌后的混合液注入高压均质乳化机中，同步完成纳米化及微脂体制作。
  21. 根据权利要求15所述的具有缓解酸痛功能的多种天然植物萃取液混合制剂的制备方法，其特征是，该油脂包含：甘油6.0～7.0％，及冬青油3.0～3.5％，及薄荷油1.0～2.0％，及不包含猪的动物油脂0.025-0.035％，各质量分数以油脂总质量为基准。
PCT/CN2014/091612 2014-11-19 2014-11-19 一种具有缓解酸痛功能的多种天然植物萃取液混合制剂及制备方法 WO2016078032A1 (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
PCT/CN2014/091612 WO2016078032A1 (zh) 2014-11-19 2014-11-19 一种具有缓解酸痛功能的多种天然植物萃取液混合制剂及制备方法
CN201480001294.8A CN105813647A (zh) 2014-11-19 2014-11-19 一种具有缓解酸痛功能的多种天然植物萃取液混合制剂及制备方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2014/091612 WO2016078032A1 (zh) 2014-11-19 2014-11-19 一种具有缓解酸痛功能的多种天然植物萃取液混合制剂及制备方法

Publications (1)

Publication Number Publication Date
WO2016078032A1 true WO2016078032A1 (zh) 2016-05-26

Family

ID=56013068

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2014/091612 WO2016078032A1 (zh) 2014-11-19 2014-11-19 一种具有缓解酸痛功能的多种天然植物萃取液混合制剂及制备方法

Country Status (2)

Country Link
CN (1) CN105813647A (zh)
WO (1) WO2016078032A1 (zh)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070248694A1 (en) * 2006-04-25 2007-10-25 Phytomyco Research Corporation Anti-inflammatory properties of a standardized extract from Euphorbia hirta (PM-251) activity and for treating conditions of inflammation
CN104013738A (zh) * 2014-06-15 2014-09-03 张晓燕 一种治疗细菌性阴道炎的中药及其制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100540014C (zh) * 2005-06-10 2009-09-16 广州陈李济药厂 一种植物提取物和它的制备方法及用途

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070248694A1 (en) * 2006-04-25 2007-10-25 Phytomyco Research Corporation Anti-inflammatory properties of a standardized extract from Euphorbia hirta (PM-251) activity and for treating conditions of inflammation
CN104013738A (zh) * 2014-06-15 2014-09-03 张晓燕 一种治疗细菌性阴道炎的中药及其制备方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JIANGSU NEW MEDICAL COLLEGE, TRADITIONAL CHINESE MEDICINE DICTIONARY, 31 May 2003 (2003-05-31), pages 1694, 1695, 1713 and 1915 *

Also Published As

Publication number Publication date
CN105813647A (zh) 2016-07-27

Similar Documents

Publication Publication Date Title
US20060269567A1 (en) Universal detoxifying composition
CN108452275A (zh) 一种具有舒筋活络功效的组合物、药剂及制备方法
CN105362410B (zh) 一种治疗烧烫伤的中药制剂及制备方法
US10758578B2 (en) Herbal formulations of carnivorous plants and methods for treating inflammation
CN102526411A (zh) 一种治疗外科伤口的中药组合物
CN101439114B (zh) 一种治疗烧烫伤的中药及其制备方法
CN102579514A (zh) 一种八角枫的炮制方法
CN102274380B (zh) 治疗烧、烫伤的外用药
CN102697835B (zh) 治疗皮肤疾病的外用药剂
CN109125641A (zh) 复方白鲜皮软膏及其制备方法
CN104474528A (zh) 用于引流排毒的药物
TWI556825B (zh) A variety of natural plant extracts to relieve acid and pain and its preparation method
CN102133286B (zh) 一种治疗烧烫伤的药膏及其制备方法
WO2016078032A1 (zh) 一种具有缓解酸痛功能的多种天然植物萃取液混合制剂及制备方法
DK201670336A1 (en) A Barbados aloe scar eliminating ointment
CN102697855B (zh) 治疗皮肤疾病的药物组合物
CN105232650B (zh) 一种治疗烫伤的药膏及其制备和使用方法
CN103893422B (zh) 修复皮肤损伤的药物及其制备方法
CN106955314A (zh) 活血清热川黄散
CN101099781B (zh) 一种治疗中晚期脑肿瘤的外用中药
CN105477081A (zh) 一种祛痘药液的制备方法
CN105596418A (zh) 一种治疗ⅱ度烧伤的中药及制备方法
CN101904915B (zh) 一种用于促进烧伤快速恢复的中药组合物
CN108464992A (zh) 一种治疗烧伤创疡的配方及其制备工艺及其应用方法
TWI535447B (zh) 抑制腫瘤生長之草藥萃取物

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 14906527

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 14906527

Country of ref document: EP

Kind code of ref document: A1