WO2016077160A1 - Procédé de durcissement par immersion - Google Patents

Procédé de durcissement par immersion Download PDF

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Publication number
WO2016077160A1
WO2016077160A1 PCT/US2015/059383 US2015059383W WO2016077160A1 WO 2016077160 A1 WO2016077160 A1 WO 2016077160A1 US 2015059383 W US2015059383 W US 2015059383W WO 2016077160 A1 WO2016077160 A1 WO 2016077160A1
Authority
WO
WIPO (PCT)
Prior art keywords
uncured
layer
shell
prosthetic material
mold
Prior art date
Application number
PCT/US2015/059383
Other languages
English (en)
Inventor
R. Alastair Winn
Nolan Pasko
Original Assignee
Applied Silicone Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Silicone Company filed Critical Applied Silicone Company
Publication of WO2016077160A1 publication Critical patent/WO2016077160A1/fr

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C35/00—Heating, cooling or curing, e.g. crosslinking or vulcanising; Apparatus therefor
    • B29C35/02—Heating or curing, e.g. crosslinking or vulcanizing during moulding, e.g. in a mould
    • B29C35/04—Heating or curing, e.g. crosslinking or vulcanizing during moulding, e.g. in a mould using liquids, gas or steam
    • B29C35/041—Heating or curing, e.g. crosslinking or vulcanizing during moulding, e.g. in a mould using liquids, gas or steam using liquids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C41/00—Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor
    • B29C41/003—Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor characterised by the choice of material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C41/00—Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor
    • B29C41/02—Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor for making articles of definite length, i.e. discrete articles
    • B29C41/14—Dipping a core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/12—Mammary prostheses and implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2240/00—Manufacturing or designing of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C35/00—Heating, cooling or curing, e.g. crosslinking or vulcanising; Apparatus therefor
    • B29C35/02—Heating or curing, e.g. crosslinking or vulcanizing during moulding, e.g. in a mould
    • B29C35/04—Heating or curing, e.g. crosslinking or vulcanizing during moulding, e.g. in a mould using liquids, gas or steam
    • B29C35/041—Heating or curing, e.g. crosslinking or vulcanizing during moulding, e.g. in a mould using liquids, gas or steam using liquids
    • B29C2035/042—Heating or curing, e.g. crosslinking or vulcanizing during moulding, e.g. in a mould using liquids, gas or steam using liquids other than water
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C59/00—Surface shaping of articles, e.g. embossing; Apparatus therefor
    • B29C59/02—Surface shaping of articles, e.g. embossing; Apparatus therefor by mechanical means, e.g. pressing
    • B29C2059/028—Incorporating particles by impact in the surface, e.g. using fluid jets or explosive forces to implant particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2083/00—Use of polymers having silicon, with or without sulfur, nitrogen, oxygen, or carbon only, in the main chain, as moulding material
    • B29K2083/005—LSR, i.e. liquid silicone rubbers, or derivatives thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2031/00—Other particular articles
    • B29L2031/753—Medical equipment; Accessories therefor
    • B29L2031/7532—Artificial members, protheses

Definitions

  • the present invention is directed to the art of curing thin silicone sheets. More particularly, the invention is directed to a method of curing the silicone elastomer shell of a dip formed breast prosthesis.
  • Various methods have been employed to manufacture breast prostheses by dip fomiing and curing a silicone outer shell, and then filling the cured shell with saline, gel or other material.
  • the shell is typically formed by dipping a mandrel into a bath of solvent dispersed silicone, and then devolatilizing the solvent from the applied layer of silicone elastomer after the dipping process. Additional layers of silicone, having the same or different properties, may be built up on the mandrel. For example, a base layer will be deposited, followed by a barrier layer, and then followed by another finishing layer.
  • the silicone layers While devolatilized, are not yet cured into a permanent form. Curing is typically carried out in a convection oven which may take several hours to ensure that the shell is completely cured. Alternatively, infrared heat transfer has been used effectively, but temperature control is challenging and safe time cycles are typically over 1 hour.
  • a silicone breast prostheses having a porous or textured outer surface is believed to evoke a reduced incidence and severity of capsular contracture, which is the formation of an oriented myelinated collagen biological capsule around the implant. Capsular contracture occurs when myelinated collagen films contract and the implant becomes visibly spherical and very firm.
  • Various methods have been used to texture the surface of a silicone breast prosthesis. In one method, a layer of silicone or urethane foam is formed on the top surface of the implant. In another prior method, the surface of a mold or mandrel is etched so that the etched pattern is transmitted to the shell of the prosthesis when the shell is formed in the mold or on the mandrel.
  • a soluble material such as, for example, a salt
  • a soluble salt material is incorporated into outer layer of the silicone shell.
  • the soluble salt material is then removed after curing the shell, thus leaving voids where the salt used to be after the shell is cured.
  • the present invention satisfies these and other needs.
  • the invention includes a system and method for efficiently curing a thin dipped formed silicone elastomer shell by immersing the uncured elastomer into a hot liquid bath for a predetermined period of time.
  • the hot liquid bath will generally be heated to a temperature in the range of 95 degrees centigrade to 160 degrees centigrade. Curing the silicone shell in this manner results in a fully cured shell in far less time than is required for curing the same prosthesis in a convection oven or IR system.
  • the invention includes a system and method for curing a thin silicone shell mounted on a mandrel by immersing the prosthesis shell and mandrel into a hot liquid bath.
  • a method is advantageous in that it eliminated the need to remove the delicate uncured silicone shell from the mandrel before curing the shell in a convection oven.
  • the invention includes a system and method wherein a silicone prosthesis shell is formed on a mandrel by dip forming layers of silicone on the mandrel, and then incorporating a soluble material, such as a salt, into one or more layers of the shell, and then curing the shell on the mandrel by immersing the shell and mandrel into a hot bath of liquid that will dissolve or otherwise remove salt or other soluble particles.
  • a soluble material such as a salt
  • the method includes curing a silicone shell by immersing the shell while still on its mandrel in a series of baths to prevent thermal shock or to ensure complete removal of any solvent remaining in the uncured silicone shell.
  • the shell and mandrel may be immersed in a first bath having a temperature of, for example, 60 degrees centigrade, and then placed in a second bath having a temperature of, for example, 130 degrees centigrade.
  • the method includes immersing the cured silicone shell into a "cold" bath to quickly cool the cured shell and mandrel to allow for further processing or handling of the shell and mandrel.
  • the system and method includes forming a silicone shell on a mandrel, immersing the uncured silicone shell and mandrel in a hot liquid bath to cure the silicone elastomer shell, and then applying one or more additional layers of uncured silicone to the cured silicone shell, incorporating a soluble particulate material into the uncured layers of silicone, and then immersing the coated shell and mandrel into a bath of hot liquid to cure the additional layer or layers of silicone and to dissolve the soluble particulate material from the additional layer or layers of silicone to produce a textured surface on the prosthesis shell.
  • the cured shell and mandrel may be immersed in a cold liquid bath after the initial hot liquid bath to cool the shell and mandrel before the additional one or more layers of uncured silicone are applied to the cooled, cured, silicone shell.
  • the present invention includes a method for manufacturing a thin sheet of prosthetic material, comprising: applying a solution of uncured prosthetic material to a mold; and curing the applied uncured prosthetic material by immersing the mold and applied uncured prosthetic material in a hot liquid bath.
  • the uncured prosthetic material is silicone.
  • the mold is a mandrel.
  • the liquid in the hot liquid bath is water having a temperature greater than 50 degrees centigrade.
  • the liquid in the hot liquid bath is a liquid having a low solubility in uncured silicone.
  • the liquid has a temperature in the range of 120 to 150 degrees centigrade. In an alternative aspect, the temperature is 130 degrees centigrade. In another alternative aspect, the liquid has a temperature in the range of 120 to 150 degrees centigrade. In still another alternative aspect, the temperature is 110 to 140 degrees centigrade.
  • the liquid is a non-toxic liquid.
  • the nontoxic liquid is selected from the group consisting of propylene glycol, polyethylene glycol, esterified polyethylene glycol and fatty acid esters.
  • the liquid is a eutectic salt having a melting point of less than 200 degrees centigrade.
  • the liquid is a eutectic metal having a melting point of less than 200 degrees centigrade.
  • applying the solution of uncured prosthetic material forms an uncured breast implant shell.
  • applying the solution of uncured prosthetic material includes dipping the mold into the solution of uncured prosthetic material.
  • dipping the mold into the solution of uncured prosthetic material forms a layer of uncured prosthetic material on the mold having a thickness of less than 1 millimeter.
  • applying the solution of uncured prosthetic material includes spraying the solution of uncured prosthetic material onto the mold.
  • the method further comprises applying a second layer of uncured prosthetic material to the mold; and curing the second layer of uncured prosthetic material by immersing the mold and uncured second layer of uncured prosthetic material in a hot liquid bath.
  • the second layer of uncured prosthetic material includes texture components.
  • curing the second layer of uncured prosthetic material by immersing the mold and uncured second layer into the hot liquid bath also dissolves the texturing components from the uncured second layer such that the cured second layer has a textured outer surface.
  • the method includes mechanically applying a texture to a top surface of the applied uncured prosthetic material before immersing the applied uncured prosthetic material and mold into the hot liquid bath.
  • FIGURE 1 is a side view of an embodiment of a process for applying a liquid prosthetic material to a mold or mandrel.
  • FIG. 2 is a sectional side view of an embodiment of a process for curing the liquid prosthetic material applied to the mold or mandrel of FIG. 1 by immersing the mold or mandrel into a hot liquid bath.
  • FIG. 3 is a perspective view of a layer of uncured prosthetic material including texture components formed over a cured layer of prosthetic material applied to a mold or mandrel.
  • FIG. 4 is a perspective view of the embodiment of FIG. 3 after the mold or mandrel has been immersed in a hot liquid bath to cure the layer of prosthetic material and dissolve the texture components.
  • FIG. 5 is a flow chart illustrating a process in accordance with an embodiment of the invention.
  • FIG. 6 is a flow chart illustrating a process for forming multiple layers of prosthetic material in accordance with an embodiment of the invention.
  • FIG. 1 an embodiment of the invention wherein a mandrel 10 is dip coated with a liquid material 15, such as, for example, silicone elastomer base, that is dripped or sprayed onto the mandrel from delivery assembly 20. Excess liquid material 15 may be caught in basin 25. Alternatively, the mandrel may be dipped into a bath of the liquid material, or the shell may be formed on or in a mold. [0028] The liquid material will then typically be exposed to a stream of air (not shown) to devolatilize solvent in the applied liquid material. The mandrel may then be again exposed to the delivery assembly 20 again to form an additional layer of material on the mandrel. These steps are repeated until a desired thickness of the shell has been achieved.
  • a liquid material 15 such as, for example, silicone elastomer base
  • the mandrel 10 and uncured shell 110 are placed in a bath 100 of hot liquid 105.
  • the temperature of the hot liquid 105 may be, for example, in the range of 50 degrees centigrade to 150 degrees centigrade, and preferably 130 degrees centigrade.
  • the mandrel and shell will typically be immersed in the hot liquid 105 for a period of time ranging from two minutes to ten or more minutes, and preferably immersed for five minutes, depending on how long it takes to devolatilize and cure the shell material.
  • the mandrel and shell may be rinsed and dried, although those steps may not be necessary, and then the additional layers are formed on the shell as discussed above.
  • the additional layer or layers may be formed from the same liquid material as a previous layer, or the additional layer or layers may be formed from a different liquid material having different properties than a previous layer or layers.
  • a "barrier" layer may be formed on top of a "base” layer to prevent bleed through of materials used to fill the shell to form the ultimate prosthesis.
  • the uncured layer may be cured by immersing the mandrel and shell into the hot liquid bath for a period of time selected to ensure that the uncured layer of the shell is cured.
  • the mandrel and uncured shell may be first placed in a hot liquid bath at a temperature of 50-60 degrees centigrade to prevent damage to the shell or mandrel due to thermal shock, or the ensure that the shell is completely devolatilized before the mandrel and uncured shell are then placed in a second hot bath.
  • this process may be repeated several times, using a series of baths of increasing temperature, depending upon the material or materials being used to form the shell.
  • the rinse step may include immersion in a cold liquid bath to quickly remove residual heat from the mandrel and cured shell to allow for more rapid subsequent processing of the shell or handling of the mandrel.
  • the temperature of the cold bath will typically be less than 50 degrees centigrade, and preferably 25 degrees centigrade.
  • the liquid of the hot and cold baths may be, for example, water. In other words, water
  • the liquid may be selected to be compatible with the shell and mandrel materials.
  • the liquid used in the baths may be chemical with low solubility in uncured silicone, such as, for example, a non-toxic chemical such as a glycol derivative, including propylene glycol and polyethylene glycol, esterified polyethylene glycol, fatty acid esters and the like.
  • the liquid may also be a eutectic salt or metal with a melting point of less than 200 degrees centigrade, and having a melting point preferably below 130 degrees centigrade.
  • FIG. 3 depicts an embodiment wherein a first layer 210 has been formed on a mandrel 205. First layer 210 has been cured by immersing the mandrel and the first layer in a hot liquid bath as described above.
  • the mandrel and cured first layer may then be rinsed or immersed in a cold bath to reduce the temperature of the mandrel and cured shell as well as to remove any residual hot liquid from the hot liquid bath.
  • a second layer of material 215 containing texture components 220 is then formed on top of the first, cured, layer by dripping or spraying the material 215 containing texture components onto the mandrel and cured first layer.
  • the mandrel and shell are immersed in a hot liquid bath.
  • the second material 215 is cured, and the texture components contained in the second material are dissolved.
  • the texture component is a salt
  • the hot liquid is chosen so that the hot liquid does not dissolve the uncured shell material, but does dissolve the texture component.
  • the hot liquid may be water, which does not dissolve silicone, but which does dissolve salt used as a texture component.
  • the texture components may be, for example, various types of salt of dissolvable plastic particles.
  • the size of the texture components are selected so as to form a surface of the shell have a particular texture topography.
  • the texture components may be between 100 and 500 microns in diameter.
  • the last layer of the shell to be cured may also be textured by applying a roll or stamp to the uncured surface of the shell, and then immersing the uncured shell in to the hot liquid bath.
  • the texture of the surface of the roll or stamp may be transferred to the uncured shell and then "frozen" on the surface of the shell when the shell is cured in the hot liquid bath.
  • FIG. 4 illustrates a shell 300 on mandrel 205 having a surface layer 305 that has a texture 310 imparted to the surface of the shell using the various embodiments of the invention described above.
  • curing the shell and dissolving the texture component in a single step simplifies the processing of the shell, eliminates additional handling of the shell and mandrel, and improves process efficiency, which also reduces the cost of manufacturing the prosthesis.
  • FIG. 5 is a flow chart illustrating the steps of one embodiment of a process 400 that may be used to form a prosthesis shell in accordance with the various embodiments of the present invention.
  • a shell is formed on a mandrel.
  • the shell and mandrel are immersed in a hot liquid bath to cure the shell material.
  • the cured shell and mandrel are rinsed or immersed in a liquid bath in box 415.
  • the rinse liquid or bath liquid may be relatively cold, such as, for example, about 25 degrees centigrade, to remove residual liquid or heat transfer medium remaining on the cured shell and mandrel from the hot liquid bath.
  • the cured shell may then be dried in box 420.
  • FIG. 6 is a flow chart illustrating the steps of one embodiment of a process 500 that may be used to form a prosthesis shell having two or more layers, which, in some embodiments, each layer may be formed of a different material.
  • a first layer is formed on a mandrel in box 505. That first layer is cured by immersing the mandrel and first layer in a hot liquid bath 510. The cured shell and mandrel are then immersed in a cool liquid bath 515. Alternatively, the cured shell and mandrel may be sprayed with a cooled liquid, and then dried.
  • a second layer of material which may be a different material than used to form the first layer, is then formed on the cured shell in box 520.
  • this second layer may be a barrier layer, or it may include texture components for forming a textured surface, or both.
  • the mandrel and shell having the second, uncured, layer is then immersed in a hot liquid bath in box 525.
  • the uncured second layer is then cured by the hot liquid, and, if the second layer includes texture components, the texture components are dissolved by the hot liquid.
  • the mandrel and cured shell may then be immersed into a cool bath as in box 530, or the mandrel and shell may be otherwise rinsed with a liquid, which may be cool in temperature. Where needed, the shell may also be rinsed in box 535, and dried in box 540.
  • FIG. 6 While the embodiment of FIG. 6 has been discussed in reference to a shell having two layers, those skilled in the art will appreciate that additional layers may be added to the shell by repeating the various steps of the process as need to achieve a shell have a desired thickness or surface properties.

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  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Thermal Sciences (AREA)
  • Prostheses (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Materials Engineering (AREA)
  • Metallurgy (AREA)
  • Organic Chemistry (AREA)

Abstract

L'invention concerne un système et un procédé de fabrication de coques de prothèse utilisant un bain liquide chaud pour le durcissement des coques. La coque est formée sur un moule ou un mandrin, puis immergée dans un bain liquide chaud pour faire durcir le matériau formant la coque. De multiples couches de matériau, par exemple d'une silicone, peuvent être formées par immersion de la couche dans un bain liquide chaud, cela étant suivi du refroidissement de la couche durcie, de l'application d'une autre couche de matériau non durci sur la couche durcie, puis du durcissement de la couche non durcie dans un bain liquide chaud. La coque peut être dotée d'une surface texturée par incorporation d'un composant de texture dans la dernière couche formée, par exemple en immergeant la couche non durcie contenant le composant de texture dans le bain liquide chaud, ce qui va entraîner le durcissement de la dernière couche formée et la dissolution du composant de texture.
PCT/US2015/059383 2014-11-12 2015-11-06 Procédé de durcissement par immersion WO2016077160A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14/539,664 2014-11-12
US14/539,664 US20160130690A1 (en) 2014-11-12 2014-11-12 Immersion Curing Process

Publications (1)

Publication Number Publication Date
WO2016077160A1 true WO2016077160A1 (fr) 2016-05-19

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US9050184B2 (en) 2008-08-13 2015-06-09 Allergan, Inc. Dual plane breast implant
US20100249924A1 (en) 2009-03-27 2010-09-30 Allergan, Inc. Bioerodible matrix for tissue involvement
US11202853B2 (en) 2010-05-11 2021-12-21 Allergan, Inc. Porogen compositions, methods of making and uses
AU2013359158B2 (en) 2012-12-13 2018-08-02 Allergan, Inc. Device and method for making a variable surface breast implant
KR102165852B1 (ko) * 2019-05-02 2020-10-14 포항공과대학교 산학협력단 지지 유체를 이용한 담금 코팅 방법 및 장치, 그리고 이를 활용한 중공 튜브 제조방법

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US4783289A (en) * 1986-04-01 1988-11-08 Toray Silicone Co., Ltd. Process for molding silicone rubber compositions
US6329444B1 (en) * 1998-10-14 2001-12-11 Apex Medical Technologies, Inc. Dip-molded medical devices from cis-1,4-polyisoprene
US20040127985A1 (en) * 1999-12-01 2004-07-01 Howard T. Bellin Non-rotating breast implant
US20140203478A1 (en) * 2008-11-20 2014-07-24 Allergan, Inc. System and method for molding soft fluid-filled implant shells
US20120010706A1 (en) * 2010-07-06 2012-01-12 Allergan, Inc. Non-rotating implant assembly and backing plate therefor

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