WO2016064199A1

WO2016064199A1 - Implant for improving wrinkles

Info

Publication number: WO2016064199A1
Application number: PCT/KR2015/011163
Authority: WO
Inventors: 이훈범; 박문서
Original assignee: 가톨릭관동대학교산학협력단
Priority date: 2014-10-21
Filing date: 2015-10-21
Publication date: 2016-04-28
Also published as: KR101693022B1; KR20160046462A

Abstract

The present invention relates to a medical implant for improving wrinkles. The implant for improving wrinkles according to the present invention comprises a xerogel which is formed in the shape of a wire and is subjected to compression and dehydration condensation from the hydrogel state, to a greater shrinkage ratio than the shrinkage ratio of simple dehydration condensation; and the xerogel is inserted into a human body and then absorbs water in the human body so as to revert to the hydrogel state prior to the compression. The present invention allows a wrinkle improving effect to be maintained over a long time while still having good compatibility with the human body since use is made of a material such as PVA or PVAc, and the invention allows improved ease of surgery since use is made of an implant in the shape of a wire that affords easy planning of surgery via an easy calculation of the volume or cross sectional area by which the implant expands, and at the same time has a small cross sectional area and is outstandingly able to maintain form.

Description

Wrinkle improvement implants

The present invention relates to a medical implant for improving wrinkles, and relates to a implant having human suitability for improving wrinkles and the like due to aging.

Various methods are used for the purpose of restoring a damaged human body such as depression due to an accident or disease or improving the appearance of a woman's breast. For example, implants, fillers, and the like may be used to aesthetically improve the shape of the chest that may be needed after tumor removal, and implants, fillers, or botox, etc., may be used to improve wrinkles and the like.

In particular, in the case of facial wrinkles may occur due to impressions or frequent laughter, such wrinkles are used botox or filler depending on the state, shape and depth. For example, in the case of shallow wrinkles, the symptoms may be alleviated by using botox to reduce muscles. If deep wrinkles have already occurred, the wrinkles may be improved by lifting or inserting fillers in addition to the botox procedure.

However, in the case of a procedure using botox or filler, there is a problem in that the effect decreases rapidly due to the fact that the contents are decomposed and absorbed by the human body after a certain period of time.

The present invention provides an implant for improving wrinkles that can be maintained permanently or semi-permanently while having good body compatibility.

In another aspect, the present invention provides an implant for wrinkle improvement that is easy to operate.

In another aspect, the present invention provides a wrinkle improvement implant that is easy to calculate the volume or cross-sectional area of the implant for wrinkle improvement.

In another aspect, the present invention provides a wrinkle-improving implant that is easy to maintain its original shape during storage or surgery.

In another aspect, the present invention provides a implant for improving wrinkles that can minimize the side effects caused by infection of pathogens even after the procedure using the implant.

The wrinkle-improving implant according to the present invention is formed in a wire shape, and includes a dry replacer which is compressed and dehydrated condensed at a larger shrinkage rate than a shrinkage rate due to simple dehydration condensation from a hydrogel state. It absorbs moisture and recovers the hydrogel state before compression.

In addition, the dry substitute may be formed of at least one material of polyvinyl alcohol (PVA) and polyvinyle acetate (PVAc).

In addition, at least one coating layer having any one of hydrophilic and hydrophobic properties may be formed on an outer surface of the dry substitute.

In addition, the coating layer may include at least one component of chitosan, dextran, calcium channel blockers, and metal ion blocking agents.

It is also coated on the outer surface of the dry substitute, at least one of polyvinyl chloride (PVC), polymer (polymer), PET (polyethylene terephthalate), nylon (nylon), polyurethane (polyurethanes), polyether block amide (Pebax) It may include an elastic thin film formed using a material of.

In addition, the outer surface of the dry substitute is a cat (cat gut), polydioxanone (Polydioxanone, PDS), polyglactin (Polyglactin, Vicryl), polyglutamic acid (PGA), polylactic acid (Polylactic acid, PLA), Poly (Lactic-co-Glycolic) Acid (PLGA) absorbent material, polyamide (nylon), polypropylene (polypropylene, prolene), polyphenyl ether (PPE), polyester ( At least one layer may be formed of a coating layer formed of any one of a polyester and a non-absorbent material of polyethylene.

In addition, at least one of the dry substitute and the coating layer may further include an antimicrobial material.

In addition, the dry substitute may further include a core wire in the concentric axis direction.

In addition, the core wire is cat (cat gut), polydioxanone (Polydioxanone, PDS), polyglutamic acid (Polyglutamic Acid, PGA), polylactic acid (Polylactic acid, PLA), Poly (Lactic-co-Glycolic Absorbent material of Polyid (PLGA), Polyglactin, Vicryl, Polyamide, Nylon, Polypropylene, Prolene, Polyester, Polyphenylether (PPE), It may be formed of any one of non-absorbent materials of polyethylene (Polyetylene).

In addition, at least one of the dry substitute and the core wire may further include an antimicrobial material.

In addition, the dry substitute may be used in a state of overlapping at least one corresponding to the depth and width of the wrinkles of the subject.

In addition, the dry substitutes may be compressed and dehydrated condensed in a state where two or more wire-like dry substitutes are twisted.

On the other hand, there is provided a method for producing an implant for improving wrinkles according to the present invention providing a water-soluble synthetic resin formed in a wire shape; A softening step of softening the water-soluble synthetic resin through hydrolysis; Compressing the softened water-soluble synthetic resin; And a dehydration condensation step of dehydrating or drying the compressed water-soluble synthetic resin.

In addition, the providing step may further include preparing a PVA sponge wire from PVA or PVAc.

In addition, the PVA sponge wire manufacturing step, to obtain a PVA aqueous solution by mixing PVA and water; Adding and stirring a pore-forming agent to the PVA aqueous solution; And acetalizing by heating after the stirring step.

In addition, the PVA sponge wire manufacturing step, hydrolyzing PVAc to obtain a PVA aqueous solution; Adding and stirring a pore-forming agent to the PVA aqueous solution; And acetalizing by heating after the stirring step.

On the other hand, as an auxiliary for inserting the wire-type wrinkle improvement implant into the human body, the auxiliary body for insertion of the wrinkle-improving implant according to the present invention includes a needle body formed in a wire shape having a predetermined length; One end of the body is formed with a first hook portion for hanging the blade and the wire-like wrinkle improvement implant.

In addition, the other end of the needle body may be formed with a second hook portion for hanging the implant for improving the wire-like wrinkles.

In the present invention, by using a material such as PVA or PVAc, the effect of improving wrinkles can be maintained permanently or semi-permanently while having good body compatibility.

In addition, according to the present invention, the volume or cross-sectional area of the prosthesis can be easily calculated to facilitate surgery, and at the same time, the ease of surgery can be increased by using a wire-shaped prosthesis having a low cross-sectional area and excellent shape retention.

Further, according to the present invention, it is easy to maintain the original shape in a compressed state at the time of storage or surgery by supplementing the characteristics of the compressed implant which naturally expands by absorbing moisture in the air.

In addition, according to the present invention it is possible to minimize the side effects due to infection of the pathogen after the procedure using the implant by including the antibiotic itself in the coating itself or the coating layer treated on the outside of the implant.

1 is a schematic diagram showing a wrinkle improvement implant according to an embodiment of the present invention.

2 is a flowchart illustrating a method for manufacturing an implant for improving wrinkles according to an exemplary embodiment.

3 (a) to 3 (c) are cross-sectional views illustrating implants for improving wrinkles according to different embodiments, respectively.

Figure 4 is a schematic diagram showing the implant for improving wrinkles according to Figure 3 (b).

Figure 5 is a schematic diagram showing the wrinkle improvement implant according to Figure 3 (c).

6 is a cross-sectional view showing a wrinkle-improving implant according to another embodiment.

7 is a schematic diagram illustrating a compression process of an implant for improving wrinkles according to an embodiment.

8 is a schematic view showing an example of a method of using an implant for improving wrinkles.

9 is a schematic diagram showing an auxiliary body (insertion needle) for inserting an implant for improving wrinkles according to an embodiment.

10 is a schematic diagram showing a method of using an insertion needle.

11 to 15 are schematic views sequentially showing a method of inserting an implant for improving wrinkles using an insertion needle.

16 and 17 are schematic diagrams showing another method of inserting an implant for improving wrinkles using an insertion needle.

Hereinafter, embodiments of the present invention will be described with reference to the accompanying drawings. Unless otherwise defined or mentioned, terms indicating directions used in the present description are based on the states shown in the drawings. In addition, the same reference numerals throughout the embodiments indicate the same member. On the other hand, each of the components shown in the drawings may be exaggerated in thickness or dimensions for the convenience of description, and does not mean that actually should be configured by the ratio between the dimensions or configurations.

With reference to Figures 1 to 8 will be described in the implant for improving wrinkles according to an embodiment and a manufacturing method thereof.

First, the configuration and manufacturing method of the implant for improving wrinkles will be described with reference to FIGS. 2 and 3. 1 is a schematic diagram showing a wrinkle improvement implant according to an embodiment of the present invention. 2 is a flowchart illustrating a method for manufacturing an implant for improving wrinkles according to an exemplary embodiment.

The wire wrinkle improvement implant according to this embodiment (10, hereinafter referred to as "wrinkle improvement implant") is formed in a thin wire (wire) or thread type having a predetermined overall length as shown in FIG. do.

In addition, the wrinkle improvement implant 10 is formed of a material that can be compressed in the direction of the central axis and the appearance restored. That is, the wrinkle improvement implant 10 is formed of xerogel, and the dry substitute may be formed using at least one of polyvinyl alcohol (PVA) and polyvinyle acetate (PVAc). The wrinkle improvement implant 10 is made of xerogel and then reacts with moisture or artificially provided moisture in the human body to exist as a hydrogel.

Hydrogel refers to a state in which when a substance is placed in a larger amount of water, the substance can swell quickly and maintain a large amount of water in the swollen structure. Substances present in the hydrogel state retain a three-dimensional structure rather than dissolve in water. Gels formed on such aqueous solutions are called hydrogels. Hydrogels are usually made of hydrophilic polymer resins that are crosslinked by other bonding forces such as chemical bonds, ionic interactions, hydrogen bonding or hydrophobic action.

The term hydrogel is applied when the material is already swollen in water. Dried gels are called xerogels or dry gels. During the drying process, moisture evaporates from the gel, and the surface tension causes the gel to crush itself. Thus the gel shrinks to a very small fraction of swollen size. If moisture is removed without disruption of the polymer structure by lyophilization or extraction with organic solvents, then the remaining material has an extremely light weight with high porosity. Such dehydrogenated hydrogels are called xerogels or sponges.

Hereinafter, for convenience of description, the wrinkle-improving implant at the manufacturing stage or the wrinkle-implanting implant which is not swelled and dried is particularly referred to as dry replacement, and the wrinkle-improving implant in the state of being swollen by moisture is particularly called a hydrogel.

Meanwhile, polyvinyl alcohol (hereinafter referred to as PVA) is a hydrophilic polymer synthetic resin obtained through hydrolysis of polyvinyl acetate (hereinafter referred to as PVAc). Crosslinking of PVA occurs through chemical and physical methods. In chemical crosslinking, an acidic crosslinking agent binds to a hydroxyl group and an aldehyde solution of PVA to form a gel. Representative methods of physical crosslinking are freeze-thawing. Hydrogels prepared by the freeze thawing method have little toxicity, contain no impurities, and contain about 80 to 90% water. In addition, since it does not use a crosslinking agent, it can be used as an attractive biomedical hydrogel.

That is, in the case of the wrinkle-improving implant made of PVA as in the present embodiment, since it maintains a certain form, there is little fear of loss of absorption in the human body and high biocompatibility, and there is no fear of necrosis of living tissue.

Referring to FIG. 2, the wire-type wrinkle improvement implant according to the present embodiment may be manufactured through a total of four steps.

First, a water-soluble synthetic resin, that is, PVA or PVAc is provided to prepare a PVA dry substitute of wire type (S10).

PVA dry substitutes are characterized by excellent elasticity and very softness in wet conditions and hardness in dried conditions, which are not only used for cleaning rollers for semiconductor wafers, glass for TFT LCDs, and for manufacturing rollers. It is also used as a material for medical gauze, beauty towels, sports towels, kitchen scaffolding mats, and microbial tins.

PVA, a raw material for PVA dry replacement, is a white powder that is insoluble in ordinary organic solvents other than water, and remains stable up to about 140 ° C. It is used as a paste for textiles, sizing of paper or an emulsifying stabilizer. PVA dry substitute is manufactured from the PVA as a raw material (S10). After mixing PVA and water in a certain ratio, the mixture was heated to obtain a PVA aqueous solution, followed by adding corn starch as a pore-forming agent, adding formalin and stirring, and then adding sulfuric acid (H 2 SO 4) as a catalyst. Then, it is injected into a mold prepared in advance, heated and acetalized to form a PVA dry substitute. The acetalized PVA dry substitute is extracted from the mold and thoroughly washed, and then cut and processed according to specifications to produce a product.

The PVA sponge manufacturing method has a problem in that even though the use regulation of harmful substances is spread, formalin or paraformaldehyde, which is a use restriction substance, must be used.

It is also possible to manufacture PVA dry substitutes using the following methods to avoid the use of environmentally regulated materials and to improve the environment of the manufacturing workplace.

First, the PVA resin of 16-21% of the water weight is weighed and mixed with water, and then heated to a temperature of 30 ° C. or higher to obtain a PVA aqueous solution, depending on the proportion of pores to form corn starch as a pore-forming agent in the PVA aqueous solution. Add 25-45% of the PVA solution. Separately, hexamethylene tetramine (28-35% of hexamethylene tetramine) by weight of water is added to water and heated to a temperature of 40 ° C. or more to obtain an aqueous solution of hexamethylene tetramine.

12 to 18% hexamethylene tetramine aqueous solution of PVA aqueous solution was added to the PVA aqueous solution, followed by stirring to obtain an aqueous PVA and hexamethylene tetramine aqueous solution. Then, an acid-based catalyst such as an aqueous sulfuric acid solution having a dilution concentration of about 50% was added to the aqueous solution. 19-21% After injection into a mold prepared in advance into the oven and heated (aged) 29-34 hours at 62 ~ 80 ℃ temperature to acetalization. The acetalized PVA sponge is extracted from the mold and thoroughly washed, and then cut and processed according to the specifications to produce a product.

The manufactured dry substitute is softened again for compression. (S20) However, the softening step of the present dry substitute is simply necessary to perform a subsequent compression (S30) step, and the same step as that of providing a water-soluble synthetic resin (S10). It is also possible to be carried out in, and is not necessarily to be performed in a separate step from the water-soluble synthetic resin providing step (S10).

On the other hand, in the case of drying by dehydrating condensation of the hydrogel receptor as described above, as the water escapes, a certain volume decreases and becomes a solid state. However, simply dehydrating condensate receptors in the hydrogel state results in insignificant volume reduction. Therefore, in the present embodiment, a compression process is further performed before drying or dehydrating the hydrogel receptor. In the compression step S30 according to the present embodiment, the wrinkle-improving implant in the swollen wire-type hydrogel state is compressed in the central axis direction. In this case, in addition to simply compressing the wrinkle-improved implant in the swollen wire-type hydrogel state, it is also possible to perform a method such as twisting two or more wire-like dry bodies together to form one dry body.

Thereafter, by drying or dehydrating the compressed receptor, it may be made into a dry state (S40).

In conclusion, the cross-sectional area of the wrinkle-improved implant in the simple dried or dehydrated state, that is, the dry substitute, is smaller than the cross-sectional area of the wrinkle-improved implant in the swollen hydrogel state and larger than the cross-sectional area of the compressed wrinkle-improved implant.

3 to 6 will be described with the implant for improving wrinkles according to another embodiment. 3A to 3C are cross-sectional views illustrating wrinkles implants according to another embodiment, and FIG. 4 is a schematic view showing wrinkles implants according to FIG. 3B. In addition, Figure 5 is a schematic diagram showing the wrinkle improvement implant according to Figure 3 (c), Figure 6 is a cross-sectional view showing a wrinkle improvement implant according to another embodiment.

Wrinkle improvement implants produced by the compressed state dry substitute described above will expand rapidly by absorbing moisture in the air compared to the general PVA dry replacer. Therefore, the wrinkle improvement implants prepared according to the present embodiment may be packaged and stored in an environment where the moisture is minimized, such as a vacuum pack, but when the corresponding package is removed for surgery, it rapidly expands by absorbing moisture in the air. .

Hereinafter will be described embodiments having a configuration capable of slowing or maximally prevent expansion of such storage and surgical waiting.

Referring to FIG. 3, the

wrinkle improvement implants

10a, 10b, and 10c may form hydrophilic and hydrophobic coating layers on the outer circumferential surface.

When the hydrophilic coating layer 13 is formed on the outer surface of the dry replaceable body 10 as shown in FIG. 3A, the moisture absorbed by the inner dry replaceable body 10 may be minimized until water in the air is sufficiently absorbed. have. Therefore, even when the packaging is removed, it is possible to prevent the dry substitute 10 from expanding and absorbing moisture in the air for a predetermined time. That is, the hydrophilic coating layer 13 formed on the outer surface is meaningful to increase the time it takes to swell. For example, a sugar coating layer or a nano sugar coating layer in a dried state may be formed on the outer surface of the dry substitute 10. Sugars are carbohydrates that are soluble in water and can be absorbed by the body.

In addition, when the hydrophobic coating layer 14 is formed on the outer surface of the dry body 10 as shown in FIG. 3 (b), the dry body 10 is further prevented by preventing moisture in the air from being directly absorbed by the dry body 10. Can increase the time it takes to absorb and swell moisture.

In addition, as shown in (c) of FIG. 3, the hydrophilic coating layer 13 and the hydrophobic coating layer 14 may be simultaneously formed on the outer surface of the dry substitute 10. In this case, the hydrophobic coating layer 14 performs the same function as in (b) of FIG. 3, but the hydrophilic coating layer 13 has a function of promoting the dry substitute 10 to absorb moisture evenly.

Specifically, as shown in FIG. 4, when only the hydrophobic coating layer 14 is formed on the outside of the dry substitute 10, water in the air or water (H) in the body after being inserted into the human body is a wrinkle improvement implant 10b. Absorbed into the dry substitute 10 through the cut portion of the). In addition, it is also possible to artificially supply moisture through the cut portion of the wrinkle improvement implant (10b). In contrast, in the case where both the hydrophilic coating layer 13 and the hydrophobic coating layer 14 are formed, absorption of the moisture H is absorbed when the moisture H is absorbed into the dry body 10 through the cut end as shown in FIG. 5. It can play a role in promoting it. Therefore, in this case, it is preferable that the hydrophilic coating layer 13 uses a material having a property of absorbing moisture as compared to the dry substitute 10.

In addition, the hydrophobic coating layer 14 may be replaced with a thin film having elasticity. For example, the material used for the balloon (angioplasty balloon) used for angioplasty, for example, PVC (polyvinyl chloride), polymer (polumer), PET (polyethylene terephthalate), nylon (nylon), polyurethane (polyurethanes), By using polyether block amide (Pebax) or the like, it is possible to coat the elastic thin film on the outer circumferential surface of the dry bridge 10. The function of this elastic thin film is similar to that of the hydrophobic coating layer. However, in the case of the elastic thin film, when the dry substitute is expanded in the process of changing to hydrogel, it is possible to expand together depending on the degree of expansion, and it is possible to minimize the occurrence of calcium deposition by the body fluid.

On the other hand, when moisture is absorbed through the cut portion as shown in FIGS. 4 and 5, the dry body 10 gradually expands, causing cracks in the outer coating layer. At this time, more moisture is absorbed into the dry substitute 10 through the crack generated, thereby further promoting expansion of the dry replacer 10.

The coating layer formed on the outer surface of the dry substitute 10 may be cat gut, polydioxanone (PDS), polyglactin (Vicryl) or polyglutamic in consideration of absorption or biocompatibility in the body. Absorbent material of polyglutamic acid (PGA), polylactic acid (PLA), poly (lactic-co-glycolic) Acid (PLGA), polyamide (nylon), polypropylene (polypropylene, prolene), It may be formed of a non-absorbent material of polyphenyl ether (Polypehyl ether, PPE), polyester (Polyester), polyethylene (Polyetylene). However, even in the case of a non-absorbent material is not absorbed in the body after several days, there is no need for a separate removal process.

On the other hand, the above-mentioned dry substitute and the coating layer may include an antimicrobial material (antimicrobial) it is possible to minimize the side effects due to pathogenic infection by antibacterial action in the body after the procedure.

In addition, chitosan, dextran, calcium channel blockers, chelating agents, and the like may be included in the coating layer or coated on the dry substitute 10 to minimize calcium deposition.

The wrinkle improvement implant according to another embodiment may further include a core wire 16 inside the dry body 10 in the concentric axis direction as shown in FIG. 6.

The core wire 16 may function as a core for the compression of the dry substitute 10 in the manufacturing stage, and may function as a core for maintaining the shape of the wrinkle improvement implant 10d in the post-manufacturing procedure.

At this time, the core wire 16 is a cat gut, polydioxanone (PDS), polyglactin (Vicryl), polyglutamic acid (Polyglutamic Acid, PGA) used as a suture ), Absorbent materials of polylactic acid (PLA), poly (Lactic-co-Glycolic) Acid (PLGA), polyamide (nylon), polypropylene (polypropylene, prolene), polyphenyl ether (Polypehyl ether) , PPE), polyester (Polyester), non-absorbent material of polyethylene (Polyetylene) and the like can be used.

In addition, as described above, the core wire 16 may further include an antimicrobial material to minimize side effects after the procedure.

Referring to Figures 7 and 8 will be described how to use the implant for improving wrinkles according to an embodiment. 7 is a schematic view showing a compression process of the wrinkle improvement implant according to an embodiment, Figure 8 is a schematic diagram showing an example of a method of using the wrinkle improvement implant.

As described above, as illustrated in FIG. 7, the wrinkle improvement implant 10 according to the present embodiment is manufactured in a compressed state at the manufacturing stage and has a minimized cross-sectional area. However, the wrinkle improvement implant 10 is restored to have the original multi-faceted area or volume by moisture in the body after the procedure. Therefore, the size, depth, cross-sectional area, etc. of the target portion, such as wrinkles that can be performed by the single wrinkle improvement implant 10 can be calculated. However, when the size or the cross-sectional area of the target part is larger than that of the single wrinkle improving implant 10, the two or more wrinkle improving implants 10 may be superimposed as illustrated in FIG. 8. .

However, the restoration described above does not mean exactly the same volume as the swelling state of the original hydrogel, but should be taken as a meaning that can be regarded as the same level in consideration of the deterioration of the surrounding pressure, wrinkle improvement implant, etc. something to do.

9 to 15, a process of inserting an implant for improving wrinkles by using an assistant (insertion needle) for inserting the implant will be described. 9 is a schematic view showing the auxiliary for inserting the implant for improving wrinkles according to an embodiment, Figure 10 is a schematic diagram showing a method of using the needle for insertion, Figures 11 to 15 for wrinkle improvement using the insertion needle It is a schematic diagram which shows sequentially how to insert a implant.

An insertion needle may be used as an aid for inserting a wire-like wrinkle improvement implant into the human body.

The insertion needle according to the present embodiment includes a needle body 20 and a blade 21.

Referring to FIGS. 9 and 10, the needle body 20 is formed of a metal material having a predetermined length, and at one end thereof, a second hook part 23 for hanging the wrinkle improvement implant described above is formed.

The blade 21 is formed at the other end of the needle body 20. Blade 21 serves to break the fibrous tissue that connects between the fascia and epidermis during the procedure. One side of the blade 21 is formed with a first hook portion 211. Like the second hook portion 23, the first hook portion 211 is used for the purpose of inserting the wrinkle improvement implant 10 formed as shown in FIG.

Meanwhile, in FIG. 9, the first hook portion 211 is formed in a bent shape, and the second hook portion 23 is formed in a hole shape penetrating the needle body, but is not limited thereto. It may be formed, or may be formed in the same shape, respectively.

Referring to FIG. 12, a cutout Ins is formed at one end of the pleats W. As shown in FIG. Thereafter, after connecting the wrinkle improvement implant 10 to the second hook portion 23, the blade 21 enters toward the incision side.

Needle body 20 is passed through the lower portion of the incision (Ins) and the wrinkles (W), as shown in Figure 13 and then taken out to the outside through the other side of the wrinkles (W) as shown in FIG. After that, the remaining portions except for the wrinkle improvement implant 10 located below the wrinkles W are cut.

Thereafter, as shown in FIG. 15, the wrinkle improvement implant 10 exposed to a large amount of moisture in the body begins to expand.

16 and 17, a method of inserting an implant for improving wrinkles using an insertion needle according to another exemplary embodiment will be described. 16 and 17 are schematic diagrams showing another method of inserting an implant for improving wrinkles using an insertion needle.

In addition to the above-described method, as shown in FIG. 16, first, the needle body 20 is exposed to the other side through the lower portion of the incision portion and the pleats W, and the wrinkle-improving prosthesis on the first hook portion 211 ( 10).

After that, as shown in FIG. 17, when the needle body 20 is pulled out again through the cutout portion Ins, the wrinkle improvement implant 10 is positioned at the lower portion of the wrinkle W as in the above-described embodiment. . The other process is the same as the previous embodiment.

Although the preferred embodiment of the present invention has been described above, the technical idea of the present invention is not limited to the above-described preferred embodiment, and may be variously implemented in a range without departing from the technical idea of the present invention specified in the claims. have.

Claims

It is formed in a wire form, and includes a dry substitute that is compressed and dehydrated condensation at a larger shrinkage rate than the shrinkage rate by a simple dehydration condensation from the hydrogel state,

The dry replacement implant for improving wrinkles to absorb the water of the human body after insertion into the hydrogel state before the compression.
The method of claim 1,

The dry substitute is a wrinkle improvement implant formed of at least one of PVA (polyvinyl alcohol), PVAc (polyvinyle acetate) material.
The method of claim 1,

Implants for improving wrinkles is formed on the outer surface of the dry substitute is at least one coating layer having any one of hydrophilic and hydrophobic properties.
The method of claim 3,

The hydrophilic coating layer is wrinkles implant for improving wrinkles comprising at least one of a sugar coating layer or a nano sugar coating layer.
The method of claim 3,

The coating layer comprises a chitosan (dexito), dextran (calcin), calcium channel blockers, implants for improving wrinkles comprising at least one component of metal ion blocking agents (chelating agents).
The method of claim 1,

Overlaid on the outer surface of the dry substitute, and at least one of polyvinyl chloride (PVC), polymer (polymer), PET (polyethylene terephthalate), nylon (nylon), polyurethane (polyurethanes), polyether block amide (Pebax) An implant for wrinkle improvement comprising an elastic thin film formed using a material.
The method of claim 1,

Cat gut, polydioxanone (PDS), polyglactin, Vicryl, polyglutamic acid (PGA), polylactic acid (Polylactic acid) on the outer surface of the dry substitute , PLA), Poly (Lactic-co-Glycolic) Acid (PLGA) absorbent material and polyamide (Polyamide, Nylon), polypropylene (polypropylene, Prolene), polyphenyl ether (PPE), polyester (Polyester) ), Wrinkles implant for improving wrinkles formed of at least one layer of the coating layer formed of any one of non-absorbent material of polyethylene (polyethylene).
The method of claim 7, wherein

At least one of the dry substitute and the coating layer is a wrinkle improvement implant further comprises an antimicrobial (antimicrobial).
The method of claim 1,

The dry substitute is a wrinkle improvement implant further comprises a core wire in the concentric axial direction.
The method of claim 9,

The core wire is cat (gut), polydioxanone (Polydioxanone, PDS), polyglactin (Polyglactin, Vicryl), polyglutamic acid (Polyglutamic Acid, PGA), polylactic acid (PLA) , Absorbent material of Poly (Lactic-co-Glycolic) Acid (PLGA) and polyamide (Polyamide, Nylon), polypropylene (Propropylene), polyphenylether (Polypehyl ether, PPE), Polyester (Polyester), Polyethylene A wrinkle improvement implant formed of any one of (Polyetylene) non-absorbent materials.
The method of claim 10,

At least one of the dry substitute and the core wire is a wrinkle improvement implant further comprises an antimicrobial (antimicrobial).
The method of claim 1,

The dry substitute is a wrinkle improvement implant used in one or more overlapping state corresponding to the depth and width of the wrinkles of the subject to be applied.
The method of claim 1,

The dry substitute is a wrinkle-improving implant that is compressed and dehydrated condensed in the twisted state of the two or more wire-shaped dry replacement.
Providing a water-soluble synthetic resin formed in a wire shape;

A softening step of softening the water-soluble synthetic resin through hydrolysis;

Compressing the softened water-soluble synthetic resin; And

The dehydration condensation step of dewatering or drying the compressed water-soluble synthetic resin; Producing implant for improving wrinkles comprising.
The method of claim 14,

The providing step further comprises the step of preparing a PVA sponge wire from PVA or PVAc implants for improving wrinkles.
The method of claim 15,

The PVA sponge wire manufacturing step,

Mixing PVA and water to obtain an aqueous PVA solution;

Adding and stirring a pore-forming agent to the PVA aqueous solution;

And acetalizing by heating after the stirring step; implant for improving wrinkles comprising a.
116. The method of claim 116 wherein

The PVA sponge wire manufacturing step,

Hydrolyzing PVAc to obtain an aqueous PVA solution;

Adding and stirring a pore-forming agent to the PVA aqueous solution;

And acetalizing by heating after the stirring step; implant for improving wrinkles comprising a.
As a supplement for inserting a wire wrinkle implant implant into the human body,

It includes; a needle body formed in a wire shape having a predetermined length;

One end of the needle body is an auxiliary for the insertion of the wrinkle improvement implant is formed with a first hook portion for hanging the blade and the wire-type wrinkle improvement implant.
The method of claim 18,

The other end of the needle body is an auxiliary for inserting the wrinkle improvement implant is formed with a second hook portion for hanging the wire-type wrinkle improvement implant.