WO2019140572A1

WO2019140572A1 - Wound dressing and manufacturing method thereof

Info

Publication number: WO2019140572A1
Application number: PCT/CN2018/073026
Authority: WO
Inventors: 张俊丰; 董杰; 莫晋文; 陈伟伟
Original assignee: 惠州华阳医疗器械有限公司
Priority date: 2018-01-17
Filing date: 2018-01-17
Publication date: 2019-07-25

Abstract

A wound dressing and a manufacturing method thereof. The wound dressing comprises two or more of a gel fiber, a textile fiber, and a thermoplastic fiber. The gel fiber content is 50-100%. The textile fiber content is 0-50%. The thermoplastic fiber content is 0-20%. The wound dressing gram weight is 60-200 g/cm². The thickness is 0.5-5.0 mm. The fluid absorption is at least 10 g/100 cm² of 0.9% saline solution. The manufacturing method comprises: providing a mixture of the gel fiber, the textile fiber, and the thermoplastic fiber and blending the same; needling the blended wound dressing; and thermosetting the needled wound dressing by hot rolling. The wound dressing composition can undergo gelation after contacting wound exudate and is able to maintain the integrity of the dressing when peeled after use.

Description

[Name of invention made by ISA according to Rule 37.2] A wound dressing and preparation method thereof

Technical field

The present invention relates to a dressing, in particular a wound dressing and a method of making the same.

Background technique

Currently, high-absorption functional wound dressings based on wet healing theory, such as alginate dressings, carboxymethyl cellulose dressings and chitosan dressings, are widely used in acute and chronic wound care. When the wound dressing contacts the wound exudate, it forms a soft gel that provides an ideal moist environment for wound healing. However, when the dressing is used after being removed from the wound, the dressing cannot be completely removed due to the structural problem of the nonwoven fabric itself. The collapse or rupture of the dressing causes a portion of the dressing to remain in the wound, posing a risk that the wound must be flushed.

Therefore, based on the above drawbacks, there is an urgent need in the market to provide a wound dressing composition capable of gelling upon contact with human wound exudate, and a wound dressing capable of maintaining the integrity of the dressing after removal and a method of preparation.

Summary of the invention

Based on this, the present invention overcomes the deficiencies of the prior art by providing a wound dressing composition capable of gelling after contact with human wound exudate, and a wound dressing capable of maintaining the integrity of the dressing after removal after use. And a preparation method.

The technical proposal is as follows: a wound dressing consisting of two or more kinds of fibers containing gel fiber, textile fiber and thermoplastic fiber, the gel fiber content is 50% to 100%, and the textile fiber content is 0%. 50%, the thermoplastic fiber content is 0% to 20%; the wound dressing has a gram weight of 60-200 g/cm2, a thickness of 0.5-5.0 mm, and a 0.9% saline solution having a liquid absorption of not less than 10 g/100 cm2.

Further optimized as the above technical solution, the gel fiber is sodium carboxymethyl cellulose, chemically modified cellulose fiber, pectin fiber, alginate fiber, chitosan fiber, hyaluronic acid fiber, polysaccharide fiber. Or one of the gum fibers.

As a further optimization of the above technical solution, the cellulose fibers are having a degree of substitution of at least 0.05 carboxymethyl groups per glucose unit.

As a further optimization of the above technical solution, the gel fiber is an absorbent having at least 2 g of a 0.9% saline solution per gram of fiber.

As a further optimization of the above technical solution, the textile fiber is one of a tencel fiber, a viscose fiber, a nylon fiber, a polyester fiber, a nylon fiber, and a cotton fiber.

As a further optimization of the above technical solution, the thermoplastic fiber is one or more of PE fiber, PP fiber, PET fiber, PS fiber, ABS fiber, PE/PET fiber, PE/PP fiber.

A method of preparing a wound dressing comprising the above wound dressing, the method for preparing a wound dressing comprising the steps of:

S1, the mixed fiber provided has a gel fiber content of 50% to 100%, a textile fiber content of 0% to 50%, a thermoplastic fiber content of 0% to 20%, and the gel fiber, textile fiber and thermoplastic Fiber blending;

S2, the wound dressing after the blending is subjected to acupuncture, and the needle is inserted into the next step;

S3. The wound dressing after the needle punching is hot-rolled and set, and the temperature during hot rolling is not less than 110 °C.

The beneficial effects of the present invention are: the wound dressing is a composition, which is simple in preparation method, and the wound dressing composition can gel after contacting the human wound exudate, and can maintain the integrity of the dressing after being removed after use. Sex.

Detailed ways

A wound dressing provided by an embodiment of the present invention comprises two or more kinds of fibers including gel fiber, textile fiber and thermoplastic fiber, wherein the gel fiber content is 50% to 100%, and the textile fiber content is 0%. ～50%, the thermoplastic fiber content is 0% to 20%; the wound dressing has a gram weight of 60-200 g/cm2, a thickness of 0.5-5.0 mm, and a 0.9% saline solution having a liquid absorption of not less than 10 g/100 cm2.

In one embodiment, the gel fiber is sodium carboxymethyl cellulose, chemically modified cellulose fiber, pectin fiber, alginate fiber, chitosan fiber, hyaluronic acid fiber, polysaccharide fiber or gum. One of the fibers.

In one embodiment, the cellulosic fibers are having a degree of substitution of at least 0.05 carboxymethyl groups per glucose unit.

In one embodiment, the gel fiber is absorbent having at least 2 grams of 0.9% saline solution per gram of fiber.

In one embodiment, the textile fiber is one of a tencel fiber, a viscose fiber, a nylon fiber, a polyester fiber, a nylon fiber, and a cotton fiber.

The wound dressing is a composition which is simple to prepare and which is capable of gelling upon contact with human wound exudate and which maintains the integrity of the dressing upon removal after use.

Based on the prior art, the present invention forms a wound dressing having a three-dimensional network structure by blending, acupuncture and hot rolling a gel fiber, a textile fiber and a thermoplastic fiber. The three components of the dressing have their own functions, the gel fiber has high liquid absorption property, can form a soft gel, and provides an ideal moist environment for wound healing; the textile fiber can increase the wet strength of the dressing, improve the wicking effect; thermoplastic After the fiber is hot rolled, a three-dimensional network structure is formed, which increases the wet strength and reduces the fiber drop. The wound dressing prepared by the method has the advantages of high liquid absorption, less fiber drop, less gel shrinkage, high wet strength, good compliance, and can be removed as a whole.

The technical effects brought by the invention have the advantages of high liquid absorption, less fiber drop, small shrinkage ratio, enhanced wet strength and good compliance.

The above-described embodiments are merely illustrative of several embodiments of the present invention, and the description thereof is more specific and detailed, but is not to be construed as limiting the scope of the invention. It should be noted that a number of variations and modifications may be made by those skilled in the art without departing from the spirit and scope of the invention. Therefore, the scope of the invention should be determined by the appended claims.

Claims

A wound dressing comprising: a gel fiber, a textile fiber, a thermoplastic fiber or two or more fibers, the gel fiber content being 50% to 100%, and the textile fiber content being 0% to 50% %, thermoplastic fiber content is 0% to 20%; the wound dressing has a basis weight of 60-200 g/cm2, a thickness of 0.5-5.0 mm, and a 0.9% saline solution having a liquid absorption of not less than 10 g/100 cm2.
A wound dressing according to claim 1, wherein the gel fibers are sodium carboxymethyl cellulose, chemically modified cellulose fibers, pectin fibers, alginate fibers, and chitosan fibers. One of hyaluronic acid fiber, polysaccharide fiber or gum fiber.
A wound dressing according to claim 2 wherein said cellulosic fibers are substituted with at least 0.05 carboxymethyl groups per glucose unit.
A wound dressing according to claim 2 wherein said gelatinous fibers are absorbent having at least 2 grams of 0.9% saline solution per gram of fiber.
A wound dressing according to claim 1, wherein the textile fiber is one of tencel fiber, viscose fiber, nylon fiber, polyester fiber, nylon fiber, and cotton fiber.
A wound dressing according to claim 1, wherein said thermoplastic fiber is one of PE fiber, PP fiber, PET fiber, PS fiber, ABS fiber, PE/PET fiber, PE/PP fiber or A variety of combinations.
A method of preparing a wound dressing comprising a wound dressing according to any of claims 1-6, wherein the method of preparing a wound dressing comprises the steps of:

S1, the mixed fiber provided has a gel fiber content of 50% to 100%, a textile fiber content of 0% to 50%, a thermoplastic fiber content of 0% to 20%, and the gel fiber, textile fiber and thermoplastic Fiber blending;

S2, the wound dressing after the blending is subjected to acupuncture, and the needle is inserted into the next step;

S3. The wound dressing after the needle punching is hot-rolled and set, and the temperature during hot rolling is not less than 110 °C.