WO2016063105A1 - Composición para el tratamiento de ectoparasitosis y la promoción del crecimiento en acuicultura - Google Patents
Composición para el tratamiento de ectoparasitosis y la promoción del crecimiento en acuicultura Download PDFInfo
- Publication number
- WO2016063105A1 WO2016063105A1 PCT/IB2014/065478 IB2014065478W WO2016063105A1 WO 2016063105 A1 WO2016063105 A1 WO 2016063105A1 IB 2014065478 W IB2014065478 W IB 2014065478W WO 2016063105 A1 WO2016063105 A1 WO 2016063105A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- aquaculture
- further characterized
- aquatic species
- external protective
- protective compound
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
- A01N33/02—Amines; Quaternary ammonium compounds
- A01N33/04—Nitrogen directly attached to aliphatic or cycloaliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/132—Amines having two or more amino groups, e.g. spermidine, putrescine
Definitions
- the present invention is related to the treatment and prevention of diseases and the promotion of growth in aquatic animals, preferably those obtained through aquaculture. More particularly the present invention is related to a composition useful in the treatment of ectoparasitosis and as a growth promoter in aquaculture.
- Infestations of fish and aquaculture animals especially caused by external parasites such as the copepods Caligus spp, Argulus spp and Cyclops spp, or protozoa such as Trichodina spp and Ichthyophthirius spp, affect the production efficiency, cause stress and damage the fish or other cultured animals, and often act as facilitators for a secondary infection or a possible vector for other pathogens.
- parasitic infestations in cultured aquatic animals are not only harmful to animals; They also represent a constant and serious threat to wild populations, which can be infested by farm animals. For this reason, the development of effective control and treatment of parasites and other infectious diseases is also of great importance from an environmental point of view.
- Treatments are known against these parasites of aquaculture crops with various compounds such as metrifonate, dichlorvos, diflubenzuron, cypermethrin, deltamethrin or azametifos.
- Other compounds for the control of parasites of fish are described by EP0407343.
- agonists or antagonists of nicotinergic insecticide acetylcholine receptors can also be used extraordinarily against parasites in fish (EP0590425).
- WO2013 / 1 10612 describes that fish parasites, especially copepods, can be controlled by the use of keto-enoles substituted with phenyl groups.
- DE102012009572 describes agents comprising glycerol-formal and derivatives thereof for the formulation of insoluble or slightly water soluble active ingredients that are used to combat pathogens that cause disease in aquaculture crops.
- EP2425857 describes a compound for expelling parasites in fish comprising an inhibitor of folate synthesis or an inhibitor of folate activation as an active substance, which consists of sulfonamide derived compounds.
- JP2006306777 describes the use of carvacrol and / or thymol, or a composition comprising at least one of these active compounds, for the treatment of infestations caused by copepods in farm fish through food.
- Another problem presented by some of these compounds is that they can be toxic to fish or other aquaculture animals, or even to humans who consume these animals or to the environment.
- these substances must have the condition of maintaining their integrity during the digestion process and being absorbed effectively to exercise their function in soft tissues.
- a particularly important aquaculture crop is shrimp.
- the types of additives studied in shrimp feed have been fundamentally: antibiotics, probiotics, nutrients, pigments, enzymes, preservatives, antioxidants, attractants and appetite stimulants (CARRILLO, Olympia, et al. Food additives as stimulants of shrimp growth. Advances in Aquaculture Nutrition V. Memories of the V International Symposium on Aquaculture Nutrition, 2000, p. 19-22).
- technologies related to shrimp growth promoters are not yet mature enough, so shrimp production results in low yields and high price.
- EDDI ethylenediamine dihydroiodide compound
- a composition for aquaculture has been invented, characterized in that it comprises at least one external protective compound of aquatic species, alone or in combination with other compounds or excipients.
- the external protective compound of aquatic species for use in aquaculture can be formulated in various ways depending on the species and way of cultivating it, so that a composition for aquaculture comprises at least the external protective compound of aquatic species according to the principles of the present invention, either alone, or in combination with other compounds or excipients.
- the external protective compound of aquatic species is selected from ethylenediamine dihydroiodide (EDDI), potassium iodide and sodium iodide, more preferably ethylenediamine dihydroiodide (EDDI).
- the aquaculture composition of the present invention acts as an external protector of aquatic species, since it stimulates mucus secretion by mucus producing cells in the dermis and gills of aquatic species and improves their filament, which accelerates the process of tissue repair in wounds caused by ectoparasites or friction during animal transport, among other causes, and prevents secondary infections.
- the mucus that covers the dermis and gills of aquatic species acts as the first defense barrier against infectious agents such as bacteria, fungi, viruses and parasites, since it contains mucin, interferon, precipitins, lysozymes, agglutinins, protein C reactive, among others. Therefore, both the external protective compound of aquatic species itself and the aquaculture composition also work to provide prophylactic treatment against infectious agents in aquaculture.
- composition of the present invention also acts as a growth promoter in aquaculture, mainly in crustaceans of the subclass Eumalacostraca.
- ectoparasitosis is caused by ectoparasites, which may refer to one or more species of external parasites in fish.
- the ectoparasites are selected from copepods such as Caligus spp, Argulus spp, Lernea spp or Cyclops spp, or from protozoa such as Trichodina spp or Ichthyophthirius spp.
- aquaculture is understood as the set of techniques for the cultivation of aquatic species, with fish and crustaceans of the subclass Eumalacostraca being preferred.
- aquatic species susceptible to being treated with the composition are selected from fish or crustaceans of the productive, cultivated, aquarium and ornamental subclass Eumalacostraca of all age stages, living in fresh water, brackish or salty.
- fish or crustaceans of the subclass Eumalacostraca have from 1 day to 12 weeks of sowing.
- the aquaculture composition of the present invention comprises 50% to 70% by weight of at least one external protective compound of aquatic species and an aquaculture acceptable vehicle. More preferably the composition comprises from 50% to 60% by weight of the compound external protector of aquatic species in accordance with the principles of the present invention.
- the aquaculture acceptable vehicle it is preferably water.
- the external protective compound of aquatic species is selected from ethylenediamine dihydroiodide (EEDI), potassium iodide and sodium iodide, preferably ethylenediamine dihydroiodide (EEDI).
- the source of organic matter for the fattening of aquatic species of the food composition comprises natural foods, which are those naturally present in the ponds; and / or, complementary foods, which are foods that are regularly supplied to aquaculture species in cultivation.
- Natural foods can be selected from detritus, bacteria, plankton, worms, insects, snails, aquatic plants and Fish, among others.
- Complementary foods can be selected from land plants, food waste or products derived from agriculture.
- the source of organic matter for the fattening of aquatic species may comprise complements, which are mixtures of carefully selected ingredients to provide all the necessary nutritional elements for the aquatic species to grow properly.
- the source of organic matter for the fattening of aquatic species may comprise one or more of the following: fishmeal, wheat and wheat by-products, wheat flour, meat meal, feather and viscera flour, cornmeal, sorghum flour, sorghum, wheat, soy, gluten, cooked corn, fish oil, soy, vitamins, minerals, choline chloride, ascorbic acid, beer yeast, methionine, or folic acid
- the food composition of the present invention is administered to a group of aquatic species infested with ectoparasites, and / or susceptible to infestation with parasites, and / or with wounds in the dermis, caused by ectoparasites or other causes, and / or to promote its growth.
- the food composition comprises from 100 to 600 parts per million (ppm) of the external protective compound of aquatic species with respect to the total food composition.
- the food composition comprises 200 to 500 ppm of the external protective compound of aquatic species.
- the present invention also provides the use of the composition for aquaculture and / or food, for the treatment and / or prevention of ectoparasitosis, as well as to promote the growth of animals in aquaculture.
- compositions for aquaculture and / or food to stimulate the growth of White shrimp (Litopaeneus vannamei), achieving an increase in weight of between 25 and 30%.
- the way of using the food composition comprises administering the food composition to a group of aquatic expeditions as part of its normal diet.
- the food composition is administered daily for a period of 1 to 30 days, more preferably for a period of 3 to 15 days.
- the way of using the aquaculture composition comprises contacting a group of aquatic species with the aquaculture composition by means of an immersion bath.
- the immersion bath of the present invention comprises a tank, tub or fish tank containing water (with the appropriate conditions for the survival of each aquatic species) and the composition for aquaculture, such that the final concentration of the external protective compound of species Water in the immersion bath is 50 ppm to 400 ppm with respect to the total water.
- the immersion bath is prepared using 100 ppm to 571.44 ppm of the aquaculture composition in accordance with the present invention.
- the immersion bath is carried out for a time of 5 minutes to 24 hours, more preferably 5 minutes to 30 minutes. In another preferred embodiment of the invention, the immersion bath is repeated daily for a period of 1 to 30 days, more preferably for a period of 3 to 15 days.
- the salmon were separated into two groups, one test and one control, and were fed for 5 days with 3 to 5 grams daily of a base food to which ethylenediamine dihydroiodide was added at a concentration of 341.4 ppm. At the end of the 5 days the mucus filament was observed.
- the filament measured in millimeters (mm)
- the test group which was given the external protective compound of aquatic species in the food
- the filament was 24 mm. According to the results of the test, it was shown that the external protective compound of aquatic species according to the present invention improves the filament of the mucus produced in the dermis of the fish.
- test was carried out at the Sonora Aquaculture Center, using 300 black tilapia with an average weight of 300 grams (weighed on the Ohaus compact series CL scale) infested with Argulus spp.
- the 300 tilapia were randomly distributed in groups of 50 in 6 circular concrete tanks with a capacity of 10,000 liters of water with individual aeration, using an aerator with a 1 HP motor with two Maof Madan brand blades.
- the external protective compound of aquatic species used in this test according to the present invention was Ethylenediamine Dihydroiodide in a concentration of 227.6 ppm in the immersion bath.
- the exposure time in the immersion bath was 24 hours continuous.
- both test and control tanks were left without changing water and using aeration for the duration of the test.
- daily changes of 100% of the water in the tanks were made every 24 hours in the test and witness groups.
- the evaluation of the effect of the external protective compound of aquatic species was carried out in 3 tanks identified as A1, A2 and A3, each of which maintained a control group without treatment, identified as C1, C2 and C3.
- the tilapia fry were placed in groups of 190 in 30 circular tanks with a capacity of 19 liters of water each, with aeration system providing individual aeration to each tank with a 1 HP blower and through the use of plastic hoses of 3 / 16 "in diameter and a diffuser stone.
- the external protective compound of aquatic species used in this test according to the present invention was Ethylenediamine Dihydroiodide in a concentration of 13.8 ppm in the immersion bath.
- the exposure time in the immersion bath was 5, 10 and 30 minutes. From each treatment time (5, 10 and 30 minutes) 5 were performed repetitions for test groups and control groups (30 tanks in total), according to Table 8.
- both the fry of the test groups and witnesses were transferred at the end of the test to other equal tanks with clean water, and were kept under observation for 7 days in a row, in order to determine if there would be any adverse effect on the animals by essay.
- the dose of 1,113 ppm of the external aquatic species protective compound according to the present invention was demonstrated for 5, 10 and 30 minutes of exposure by means of an immersion bath is effective in eliminating ectoparasites Trichodinas spp and cause their death, having the best results with 30 minutes of immersion bath.
- the external protective compound of aquatic species used in this test according to the present invention was Ethylenediamine Dihydroiodide in a concentration of 341.44 ppm in the food.
- the external protective compound of aquatic species used in this test according to the present invention was Ethylenediamine Dihydroiodide.
- a dose of 56.9 ppm of Ethylenediamine Dihydroiodide in relation to the water in the tank was added to the test groups during the duration of the transport, which was 15 minutes.
- the fish were given food combined with Ethylenediamine Dihydroiodide in a concentration of 227.6 ppm for 7 days, the first day being the day of the transfer and the other 6 days thereafter.
- the fish were fed to satiety distributing the food 3 times a day during the 7 days of the trial.
- the external protective compound of aquatic species used in this test according to the present invention was Ethylenediamine Dihydroiodide.
- tilapia weighing between 300 and 500 grams were used, which were placed in 10 ponds with a capacity of 1,000 cubic meters of water and a planting density of 20 fish per cubic meter. Five ponds were assigned as test groups and five as control groups.
- a dose of 227.6 ppm of Ethylenediamine Dihydroiodide and 170 ppm of grenetine was added to the test groups as a binder in relation to the pond water for a period of 7 days.
- the external protective compound of aquatic species according to the present invention at 227.6 ppm is effective in protecting the dermis of fish from wounds caused by a bacterial infection and reducing mortality.
- the external protective compound of aquatic species used in this test according to the present invention was Ethylenediamine Dihydroiodide.
- the pools were monitored weekly until week 9 they were harvested.
- the postlarvae were fed commercial commercial feed (Purina Brand 32% crude protein) and only to pool 3 was added Ethylenediamine Dihydroiodide according to the present invention in an amount of 227.6 ppm.
- an external protective compound of aquatic species selected from ethylenediamine dihydroiodide (EDDI), potassium iodide, sodium iodide, guaifenesin, cresol, acetylcysteine, canfosulfonic acid, bromhexine, and compounds or substances derived from Eucalyptus spp, in aquaculture activities it provides a safe and effective treatment against ectoparasitosis, which is effective in all stages of parasite development or in free parasites, does not generate resistance from parasites, is not toxic For animals and humans, it is friendly to the environment, works at low concentrations, requires short treatment periods, and is easy to apply or administer in aquaculture crops, in addition to promoting growth in some aquatic species.
- EDDI ethylenediamine dihydroiodide
- potassium iodide sodium iodide
- guaifenesin cresol
- acetylcysteine canfosulfonic acid
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Plant Pathology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Pest Control & Pesticides (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Fodder In General (AREA)
- Feed For Specific Animals (AREA)
- Farming Of Fish And Shellfish (AREA)
Abstract
Description
Claims
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BR112017007971A BR112017007971A2 (pt) | 2014-10-20 | 2014-10-20 | composição para a aquicultura, composição alimentar para aquicultura, banho de imersão para espécies aquáticas e uso de um composto protetor externo para espécies aquáticas |
CR20170205A CR20170205A (es) | 2014-10-20 | 2014-10-20 | Composición para el tratamiento de ectoparasitosis y la promoción del crecimiento en acuicultura |
PCT/IB2014/065478 WO2016063105A1 (es) | 2014-10-20 | 2014-10-20 | Composición para el tratamiento de ectoparasitosis y la promoción del crecimiento en acuicultura |
MX2017005058A MX2017005058A (es) | 2014-10-20 | 2014-10-20 | Composicion para el tratamiento de ectoparasitosis y la promocion del crecimiento en acuicultura. |
CONC2017/0003784A CO2017003784A2 (es) | 2014-10-20 | 2017-04-19 | Composición para el tratamiento de ectoparasitosis y la promoción del crecimiento en acuicultura |
ECIEPI201731291A ECSP17031291A (es) | 2014-10-20 | 2017-05-19 | Composición para el tratamiento de ectoparasitosis y la promoción del crecimiento en acuicultura |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/IB2014/065478 WO2016063105A1 (es) | 2014-10-20 | 2014-10-20 | Composición para el tratamiento de ectoparasitosis y la promoción del crecimiento en acuicultura |
Publications (1)
Publication Number | Publication Date |
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WO2016063105A1 true WO2016063105A1 (es) | 2016-04-28 |
Family
ID=55760339
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IB2014/065478 WO2016063105A1 (es) | 2014-10-20 | 2014-10-20 | Composición para el tratamiento de ectoparasitosis y la promoción del crecimiento en acuicultura |
Country Status (6)
Country | Link |
---|---|
BR (1) | BR112017007971A2 (es) |
CO (1) | CO2017003784A2 (es) |
CR (1) | CR20170205A (es) |
EC (1) | ECSP17031291A (es) |
MX (1) | MX2017005058A (es) |
WO (1) | WO2016063105A1 (es) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104855708A (zh) * | 2015-04-30 | 2015-08-26 | 宁夏大北农科技实业有限公司 | 一种防治草鱼肝胆综合症的饲料及其制备方法 |
ES2610791A1 (es) * | 2016-12-22 | 2017-05-03 | Elena TEIJEIRA PRIETO | Uso del mebendazol para la eliminación de los gusanos de fuego en acuarios de arrecife |
CN108175002A (zh) * | 2018-02-26 | 2018-06-19 | 铜陵县黑你养殖专业合作社 | 一种高蛋白黑鱼饲料及其制备方法 |
WO2019239056A1 (fr) * | 2018-06-14 | 2019-12-19 | Ictyodev | Vecteur huileux de faible viscosite non moussant autodispersible dans l'eau |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5618574A (en) * | 1995-05-12 | 1997-04-08 | Clearwater Fish & Pond Supply, Inc. | Fish food |
ES2132382T3 (es) * | 1993-02-02 | 1999-08-16 | Buckman Labor Inc | Procedimiento para controlar a los macroinvertebrados. |
-
2014
- 2014-10-20 CR CR20170205A patent/CR20170205A/es unknown
- 2014-10-20 WO PCT/IB2014/065478 patent/WO2016063105A1/es active Application Filing
- 2014-10-20 MX MX2017005058A patent/MX2017005058A/es unknown
- 2014-10-20 BR BR112017007971A patent/BR112017007971A2/pt not_active Application Discontinuation
-
2017
- 2017-04-19 CO CONC2017/0003784A patent/CO2017003784A2/es unknown
- 2017-05-19 EC ECIEPI201731291A patent/ECSP17031291A/es unknown
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2132382T3 (es) * | 1993-02-02 | 1999-08-16 | Buckman Labor Inc | Procedimiento para controlar a los macroinvertebrados. |
US5618574A (en) * | 1995-05-12 | 1997-04-08 | Clearwater Fish & Pond Supply, Inc. | Fish food |
Non-Patent Citations (3)
Title |
---|
AVIMEX: "Mucosol.", CARTASA, 2005, XP055274851, Retrieved from the Internet <URL:http://www.cartasa.net/downloads/sitio/catalogo/pdfs/MucosolDataSheet.pdf> [retrieved on 20150609] * |
INMUNOFISH.: "Una nueva manera de ver la piscicultura.", 18 June 2008 (2008-06-18), Retrieved from the Internet <URL:https://m.facebcok.com/notes/d-an-acuacuitura/immunofish-una-nueva-manera-of-see-the-piscicultura/15857039694> [retrieved on 20150605] * |
MUCOSOL®AQUA.: "En: Mucosol@Aqua. Experiencia de uso en Ecuador .", AQUAFEED, 14 January 2014 (2014-01-14), XP055274849, Retrieved from the Internet <URL:http://aquafeed.co/mucosol%C2%AEaqua> [retrieved on 20150605] * |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104855708A (zh) * | 2015-04-30 | 2015-08-26 | 宁夏大北农科技实业有限公司 | 一种防治草鱼肝胆综合症的饲料及其制备方法 |
ES2610791A1 (es) * | 2016-12-22 | 2017-05-03 | Elena TEIJEIRA PRIETO | Uso del mebendazol para la eliminación de los gusanos de fuego en acuarios de arrecife |
WO2018115550A1 (es) * | 2016-12-22 | 2018-06-28 | Teijeira Prieto Elena | Uso del mebendazol para la eliminación de los gusanos de fuego en acuarios de arrecife |
CN108175002A (zh) * | 2018-02-26 | 2018-06-19 | 铜陵县黑你养殖专业合作社 | 一种高蛋白黑鱼饲料及其制备方法 |
WO2019239056A1 (fr) * | 2018-06-14 | 2019-12-19 | Ictyodev | Vecteur huileux de faible viscosite non moussant autodispersible dans l'eau |
FR3082421A1 (fr) * | 2018-06-14 | 2019-12-20 | Ictyodev | Vecteur huileux de faible viscosite non moussant autodispersible dans l'eau |
Also Published As
Publication number | Publication date |
---|---|
ECSP17031291A (es) | 2017-07-31 |
BR112017007971A2 (pt) | 2018-01-23 |
CR20170205A (es) | 2017-10-18 |
MX2017005058A (es) | 2017-06-20 |
CO2017003784A2 (es) | 2017-07-28 |
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