WO2016046189A1 - Combinaisons associant du loxoprofène et des médicaments antispasmodiques - Google Patents

Combinaisons associant du loxoprofène et des médicaments antispasmodiques Download PDF

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Publication number
WO2016046189A1
WO2016046189A1 PCT/EP2015/071694 EP2015071694W WO2016046189A1 WO 2016046189 A1 WO2016046189 A1 WO 2016046189A1 EP 2015071694 W EP2015071694 W EP 2015071694W WO 2016046189 A1 WO2016046189 A1 WO 2016046189A1
Authority
WO
WIPO (PCT)
Prior art keywords
pharmaceutical composition
pharmaceutically acceptable
composition according
loxoprofen
acceptable salt
Prior art date
Application number
PCT/EP2015/071694
Other languages
English (en)
Inventor
Ali TÜRKYILMAZ
Yelda Erdem
Seval Ataman
Ayse ILDES ERDEM
Gaye Ramazanoglu
Original Assignee
Sanovel Ilac Sanayi Ve Ticaret A.S.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanovel Ilac Sanayi Ve Ticaret A.S. filed Critical Sanovel Ilac Sanayi Ve Ticaret A.S.
Priority to EP15780776.9A priority Critical patent/EP3197434A1/fr
Publication of WO2016046189A1 publication Critical patent/WO2016046189A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433—Thidiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer

Abstract

L'invention concerne une nouvelle composition pharmaceutique comprenant du loxoprofène, ou un sel de qualité pharmaceutique de celui-ci, en association avec des médicaments antispasmodiques, ou des sels de qualité pharmaceutique de ceux-ci, présentant une activité anti-inflammatoire, analgésique et myorelaxante.
PCT/EP2015/071694 2014-09-24 2015-09-22 Combinaisons associant du loxoprofène et des médicaments antispasmodiques WO2016046189A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP15780776.9A EP3197434A1 (fr) 2014-09-24 2015-09-22 Combinaisons associant du loxoprofène et des médicaments antispasmodiques

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
TR201411290 2014-09-24
TR2014/11290 2014-09-24

Publications (1)

Publication Number Publication Date
WO2016046189A1 true WO2016046189A1 (fr) 2016-03-31

Family

ID=52706265

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2015/071694 WO2016046189A1 (fr) 2014-09-24 2015-09-22 Combinaisons associant du loxoprofène et des médicaments antispasmodiques

Country Status (2)

Country Link
EP (1) EP3197434A1 (fr)
WO (1) WO2016046189A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019137651A (ja) * 2018-02-14 2019-08-22 エスエス製薬株式会社 医薬組成物
US10813916B2 (en) * 2015-05-29 2020-10-27 Jubilant Generics Limited Immediate release pharmaceutical composition of tizanidine
CN113081997A (zh) * 2021-04-01 2021-07-09 杭州泓友医药科技有限公司 一种盐酸替扎尼定胶囊剂及其制备方法

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4161538A (en) 1977-04-05 1979-07-17 Sankyo Company Limited Substituted phenylacetic acid derivatives and process for the preparation thereof
GB2197198A (en) 1986-11-03 1988-05-18 Sandoz Ltd Analgesic preparations
US5260337A (en) * 1992-07-29 1993-11-09 Merck & Co., Inc. Ibuprofen-muscle relaxant combinations
WO2002047661A1 (fr) 2000-12-14 2002-06-20 Shin Poong Pharmaceutical Co., Ltd. Composition pharmaceutique pour injection intramusculaire contenant du loxoprofene
US20080279933A1 (en) * 2007-05-08 2008-11-13 Sanovel Ilac Sanayi Ve Ticaret A.S. Flurbiprofen and muscle relaxant combinations
EP0947584B1 (fr) 1996-08-26 2011-05-25 Lead Chemical Company Ltd. Preparation de Loxoprofen pour l'usage externe.
EP1806152B1 (fr) 2004-11-10 2012-08-01 Hisamitsu Pharmaceutical Co., Inc. Médicament à usage externe et patch adhésif
WO2012173581A1 (fr) * 2011-03-21 2012-12-20 Ak Kimya Ithalat-Ihracat Ve Sanayii A.S. Combinaisons de thiocolchicoside, étodolac et famotidine
JP2014094894A (ja) * 2012-11-07 2014-05-22 Kowa Company Ltd 安定な医薬組成物

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4161538A (en) 1977-04-05 1979-07-17 Sankyo Company Limited Substituted phenylacetic acid derivatives and process for the preparation thereof
GB2197198A (en) 1986-11-03 1988-05-18 Sandoz Ltd Analgesic preparations
US5260337A (en) * 1992-07-29 1993-11-09 Merck & Co., Inc. Ibuprofen-muscle relaxant combinations
EP0947584B1 (fr) 1996-08-26 2011-05-25 Lead Chemical Company Ltd. Preparation de Loxoprofen pour l'usage externe.
WO2002047661A1 (fr) 2000-12-14 2002-06-20 Shin Poong Pharmaceutical Co., Ltd. Composition pharmaceutique pour injection intramusculaire contenant du loxoprofene
EP1806152B1 (fr) 2004-11-10 2012-08-01 Hisamitsu Pharmaceutical Co., Inc. Médicament à usage externe et patch adhésif
US20080279933A1 (en) * 2007-05-08 2008-11-13 Sanovel Ilac Sanayi Ve Ticaret A.S. Flurbiprofen and muscle relaxant combinations
WO2012173581A1 (fr) * 2011-03-21 2012-12-20 Ak Kimya Ithalat-Ihracat Ve Sanayii A.S. Combinaisons de thiocolchicoside, étodolac et famotidine
JP2014094894A (ja) * 2012-11-07 2014-05-22 Kowa Company Ltd 安定な医薬組成物

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
AKIRA TANIGUCHI ET AL: "Painful neck on rotation: diagnostic significance for crowned dens syndrome", JOURNAL OF NEUROLOGY, STEINKOPFF-VERLAG, DA, vol. 257, no. 1, 30 August 2009 (2009-08-30), pages 132 - 135, XP019781052, ISSN: 1432-1459 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10813916B2 (en) * 2015-05-29 2020-10-27 Jubilant Generics Limited Immediate release pharmaceutical composition of tizanidine
JP2019137651A (ja) * 2018-02-14 2019-08-22 エスエス製薬株式会社 医薬組成物
JP6991880B2 (ja) 2018-02-14 2022-01-13 エスエス製薬株式会社 医薬組成物
CN113081997A (zh) * 2021-04-01 2021-07-09 杭州泓友医药科技有限公司 一种盐酸替扎尼定胶囊剂及其制备方法

Also Published As

Publication number Publication date
EP3197434A1 (fr) 2017-08-02

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