WO2016001017A1 - Apparatus for determining a fractional flow reserve value - Google Patents

Apparatus for determining a fractional flow reserve value Download PDF

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Publication number
WO2016001017A1
WO2016001017A1 PCT/EP2015/064168 EP2015064168W WO2016001017A1 WO 2016001017 A1 WO2016001017 A1 WO 2016001017A1 EP 2015064168 W EP2015064168 W EP 2015064168W WO 2016001017 A1 WO2016001017 A1 WO 2016001017A1
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WIPO (PCT)
Prior art keywords
coronary artery
boundary condition
artery system
determination unit
projection data
Prior art date
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PCT/EP2015/064168
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English (en)
French (fr)
Inventor
Michael Grass
Yechiel Lamash
Liran Goshen
Holger Schmitt
Mordechay Pinchas FREIMAN
Hannes NICKISCH
Sven Prevrhal
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Koninklijke Philips N.V.
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Publication date
Application filed by Koninklijke Philips N.V. filed Critical Koninklijke Philips N.V.
Priority to US15/317,158 priority Critical patent/US10258303B2/en
Priority to CN201580036011.8A priority patent/CN106659400B/zh
Priority to JP2016575410A priority patent/JP6553099B2/ja
Priority to EP15733388.1A priority patent/EP3160335B1/en
Publication of WO2016001017A1 publication Critical patent/WO2016001017A1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/02007—Evaluating blood vessel condition, e.g. elasticity, compliance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/026—Measuring blood flow
    • A61B5/029—Measuring or recording blood output from the heart, e.g. minute volume
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
    • A61B6/02—Devices for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
    • A61B6/03—Computerised tomographs
    • A61B6/032—Transmission computed tomography [CT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
    • A61B6/06—Diaphragms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
    • A61B6/40—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment with arrangements for generating radiation specially adapted for radiation diagnosis
    • A61B6/4064—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment with arrangements for generating radiation specially adapted for radiation diagnosis specially adapted for producing a particular type of beam
    • A61B6/4078—Fan-beams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
    • A61B6/42—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment with arrangements for detecting radiation specially adapted for radiation diagnosis
    • A61B6/4208—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment with arrangements for detecting radiation specially adapted for radiation diagnosis characterised by using a particular type of detector
    • A61B6/4233—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment with arrangements for detecting radiation specially adapted for radiation diagnosis characterised by using a particular type of detector using matrix detectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
    • A61B6/48—Diagnostic techniques
    • A61B6/481—Diagnostic techniques involving the use of contrast agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
    • A61B6/48—Diagnostic techniques
    • A61B6/486—Diagnostic techniques involving generating temporal series of image data
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
    • A61B6/50—Clinical applications
    • A61B6/503—Clinical applications involving diagnosis of heart
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
    • A61B6/50—Clinical applications
    • A61B6/504—Clinical applications involving diagnosis of blood vessels, e.g. by angiography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
    • A61B6/50—Clinical applications
    • A61B6/507—Clinical applications involving determination of haemodynamic parameters, e.g. perfusion CT
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
    • A61B6/52—Devices using data or image processing specially adapted for radiation diagnosis
    • A61B6/5211—Devices using data or image processing specially adapted for radiation diagnosis involving processing of medical diagnostic data
    • A61B6/5217—Devices using data or image processing specially adapted for radiation diagnosis involving processing of medical diagnostic data extracting a diagnostic or physiological parameter from medical diagnostic data
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
    • A61B6/52—Devices using data or image processing specially adapted for radiation diagnosis
    • A61B6/5288—Devices using data or image processing specially adapted for radiation diagnosis involving retrospective matching to a physiological signal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
    • A61B6/54—Control of apparatus or devices for radiation diagnosis
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/50—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
    • A61B6/48—Diagnostic techniques
    • A61B6/482—Diagnostic techniques involving multiple energy imaging

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  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Public Health (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Optics & Photonics (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physiology (AREA)
  • Dentistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Mathematical Physics (AREA)
  • Pulmonology (AREA)
  • Theoretical Computer Science (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Primary Health Care (AREA)
  • Databases & Information Systems (AREA)
  • Data Mining & Analysis (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
PCT/EP2015/064168 2014-06-30 2015-06-24 Apparatus for determining a fractional flow reserve value WO2016001017A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US15/317,158 US10258303B2 (en) 2014-06-30 2015-06-24 Apparatus for determining a fractional flow reserve value
CN201580036011.8A CN106659400B (zh) 2014-06-30 2015-06-24 用于确定血流储备分数值的装置
JP2016575410A JP6553099B2 (ja) 2014-06-30 2015-06-24 血流予備量比値を算出するための機器
EP15733388.1A EP3160335B1 (en) 2014-06-30 2015-06-24 Apparatus for determining a fractional flow reserve value

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14174891.3 2014-06-30
EP14174891 2014-06-30

Publications (1)

Publication Number Publication Date
WO2016001017A1 true WO2016001017A1 (en) 2016-01-07

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PCT/EP2015/064168 WO2016001017A1 (en) 2014-06-30 2015-06-24 Apparatus for determining a fractional flow reserve value

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US (1) US10258303B2 (zh)
EP (1) EP3160335B1 (zh)
JP (1) JP6553099B2 (zh)
CN (1) CN106659400B (zh)
WO (1) WO2016001017A1 (zh)

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US9877660B2 (en) 2013-11-14 2018-01-30 Medtronic Vascular Galway Systems and methods for determining fractional flow reserve without adenosine or other pharmalogical agent
US9913585B2 (en) 2014-01-15 2018-03-13 Medtronic Vascular, Inc. Catheter for providing vascular pressure measurements
JP2018140045A (ja) * 2017-02-28 2018-09-13 富士フイルム株式会社 血流解析装置および方法並びにプログラム
WO2018178239A1 (en) * 2017-03-31 2018-10-04 Koninklijke Philips N.V. Spectral imaging ffr
EP3384850A1 (en) * 2017-04-05 2018-10-10 Koninklijke Philips N.V. Method and apparatus for physiological functional parameter determination
US10130269B2 (en) 2013-11-14 2018-11-20 Medtronic Vascular, Inc Dual lumen catheter for providing a vascular pressure measurement
WO2019002510A1 (en) * 2017-06-30 2019-01-03 Koninklijke Philips N.V. DIGITAL TOMOGRAPHY FFR SPECTRAL WITH AUTOMATIC LEARNING
US10194812B2 (en) 2014-12-12 2019-02-05 Medtronic Vascular, Inc. System and method of integrating a fractional flow reserve device with a conventional hemodynamic monitoring system
US10201284B2 (en) 2014-06-16 2019-02-12 Medtronic Vascular Inc. Pressure measuring catheter having reduced error from bending stresses
EP3456243A1 (en) 2017-09-14 2019-03-20 Koninklijke Philips N.V. Improved vessel geometry and additional boundary conditions for hemodynamic ffr/ifr simulations from intravascular imaging
EP3457404A1 (en) 2017-09-18 2019-03-20 Koninklijke Philips N.V. Estimating flow to vessel bifurcations for simulated hemodynamics
EP3370615B1 (en) * 2015-11-05 2020-04-15 Koninklijke Philips N.V. Collateral flow modelling for non-invasive fractional flow reserve (ffr)
US10646185B2 (en) 2015-01-15 2020-05-12 Koninklijke Philips N.V. iFR-CT
US10646122B2 (en) 2017-04-28 2020-05-12 Medtronic Vascular, Inc. FFR catheter with covered distal pressure sensor and method of manufacture
US10973418B2 (en) 2014-06-16 2021-04-13 Medtronic Vascular, Inc. Microcatheter sensor design for minimizing profile and impact of wire strain on sensor
US11039804B2 (en) 2016-09-16 2021-06-22 Koninklijke Philips N.V. Apparatus and method for determining a fractional flow reserve
US11185244B2 (en) 2018-08-13 2021-11-30 Medtronic Vascular, Inc. FFR catheter with suspended pressure sensor
US11219741B2 (en) 2017-08-09 2022-01-11 Medtronic Vascular, Inc. Collapsible catheter and method for calculating fractional flow reserve
US11235124B2 (en) 2017-08-09 2022-02-01 Medtronic Vascular, Inc. Collapsible catheter and method for calculating fractional flow reserve
US11272850B2 (en) 2016-08-09 2022-03-15 Medtronic Vascular, Inc. Catheter and method for calculating fractional flow reserve
US11301994B2 (en) 2017-08-30 2022-04-12 Koninklijke Philips N.V. Coronary artery health state prediction based on a model and imaging data
US11330989B2 (en) 2014-06-16 2022-05-17 Medtronic Vascular, Inc. Microcatheter sensor design for mounting sensor to minimize induced strain
US11330994B2 (en) 2017-03-08 2022-05-17 Medtronic Vascular, Inc. Reduced profile FFR catheter
JP2022133369A (ja) * 2016-09-20 2022-09-13 ハートフロー， インコーポレイテッド 次数低減モデル及び／または機械学習を使用して血流特性を推定するためのシステム及び方法
EP4238500A1 (en) 2022-03-02 2023-09-06 Koninklijke Philips N.V. Measurement of blood flow parameters
EP4311491A1 (en) 2022-07-25 2024-01-31 Koninklijke Philips N.V. Determining a value of a blood flow parameter
EP4311496A1 (en) 2022-07-26 2024-01-31 Koninklijke Philips N.V. Blood flow parameters

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WO2018060529A1 (en) * 2016-09-30 2018-04-05 Koninklijke Philips N.V. Apparatus for determining a functional index for stenosis assessment
WO2018133118A1 (zh) 2017-01-23 2018-07-26 上海联影医疗科技有限公司 血流状态分析系统及方法
EP3378398A1 (en) 2017-03-24 2018-09-26 Koninklijke Philips N.V. Myocardial ct perfusion image synthesis
US11523744B2 (en) 2017-03-31 2022-12-13 Koninklijke Philips N.V. Interaction monitoring of non-invasive imaging based FFR
JP7229170B2 (ja) 2017-04-06 2023-02-27 コーニンクレッカ フィリップス エヌ ヴェ Ｅｃｇ信号からの心筋微小血管抵抗の推定に基づく冠状動脈疾患メトリック
JP7300392B2 (ja) 2017-04-06 2023-06-29 コーニンクレッカ フィリップス エヌ ヴェ 標準化された冠動脈疾患メトリック
EP3607558A1 (en) 2017-04-06 2020-02-12 Koninklijke Philips N.V. Fractional flow reserve simulation parameter customization, calibration and/or training
JP7160659B2 (ja) * 2018-01-11 2022-10-25 キヤノンメディカルシステムズ株式会社 医用情報処理装置、医用情報処理システム及び医用情報処理方法
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CN108511075B (zh) * 2018-03-29 2022-10-25 杭州脉流科技有限公司 一种非侵入式获取血流储备分数的方法和系统
CN108564574B (zh) * 2018-04-11 2021-04-20 上海联影医疗科技股份有限公司 确定血流储备分数的方法、计算机设备及计算机可读存储介质
CN108992057B (zh) * 2018-06-05 2021-08-10 杭州晟视科技有限公司 一种确定冠状动脉血流储备分数ffr的方法和装置
EP3624132A1 (en) * 2018-09-13 2020-03-18 Koninklijke Philips N.V. Calculating boundary conditions for virtual ffr and ifr calculation based on myocardial blush characteristics
CN110384493A (zh) * 2018-09-19 2019-10-29 苏州润迈德医疗科技有限公司 测量微循环阻力指数的系统以及冠脉分析系统
US10964017B2 (en) * 2018-11-15 2021-03-30 General Electric Company Deep learning for arterial analysis and assessment
CN109567776B (zh) * 2018-12-31 2021-08-10 深圳北芯生命科技股份有限公司 用于测试ffr主机系统的导管模拟器
US10861157B2 (en) 2019-04-04 2020-12-08 Medtronic Vascular, Inc. System and methods for determining modified fractional flow reserve values
CN110477877B (zh) * 2019-07-03 2022-04-22 北京工业大学 一种基于ffr原理建立快速判断血管狭窄阻力和微循环阻力大小模型的方法
WO2021102408A1 (en) 2019-11-22 2021-05-27 The Regents Of The University Of Michigan Anatomical and functional assessment of coronary artery disease using machine learning
CN113576439B (zh) * 2020-05-08 2023-06-13 深圳北芯生命科技股份有限公司 处理血管压力信号的主机
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Cited By (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10130269B2 (en) 2013-11-14 2018-11-20 Medtronic Vascular, Inc Dual lumen catheter for providing a vascular pressure measurement
US9877660B2 (en) 2013-11-14 2018-01-30 Medtronic Vascular Galway Systems and methods for determining fractional flow reserve without adenosine or other pharmalogical agent
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