JP2017518844A - 血流予備量比値を算出するための機器 - Google Patents
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Abstract
Description
− 冠動脈系の表現を提供するための表現提供ユニットと、
− 境界条件及び冠動脈系の提供される表現に基づいてFFR値を算出するように適合されるFFR値算出アルゴリズムを使用することによってFFR値を算出するための血流予備量比値算出ユニットと、
− 放射源によって生成され、且つ造影剤が大動脈を流れる間に生物の大動脈を横断している放射に基づいて検出器によって経時的に生成されている投影データを提供するための投影データ提供ユニットであって、検出器は投影データを生成するために使用される数行の検出素子を有し、検出素子の全ての行が照射されないが、単一の扇形ビームによって1行のみが照射されるように、又は幾つかの扇形ビームによって数行が照射されるように放射源が適合される、投影データ提供ユニットと、
− 提供される投影データに基づいて生物固有の境界条件を算出するための境界条件算出ユニットと
を含む。
− 冠動脈系の表現を表現提供ユニットによって与えるステップと、
− 境界条件及び冠動脈系の提供される表現に基づいてFFR値を算出するように構成されるFFR値算出アルゴリズムを使用することにより、血流予備量比値算出ユニットによってFFR値を算出するステップと、
− 放射源によって生成され、且つ造影剤が大動脈を流れる間に生物の大動脈を横断している放射に基づいて検出器によって経時的に生成されている投影データを投影データ提供ユニットによって提供するステップであって、検出器は投影データを生成するために使用される数行の検出素子を有し、検出素子の全ての行が照射されないが、単一の扇形ビームによって1行のみが照射されるように、又は幾つかの扇形ビームによって数行が照射されるように放射源が適合される、ステップと、
− 提供される投影データに基づいて生物固有の境界条件を境界条件算出ユニットによって算出するステップと
を含む。
Ra_micro=A(MyoMass)−1+B(CSA)−1+C (1)
によって定められ得、A、B、及びCはパラメトリック関数の係数であり、かかる係数はa)微小血管抵抗とb)人固有の断面積及び心筋質量との間の割当を提供するために、訓練データセットを使用する機械学習プロセスによって最適化され得るか、又は最適化されている。
Claims (13)
- 生物の冠動脈系の血流予備量比値を算出するための機器であって、
冠動脈系の表現を提供するための表現提供ユニットと、
境界条件及び提供される前記冠動脈系の表現に基づいて血流予備量比値を算出するFFR値算出アルゴリズムを使用することによって血流予備量比値を算出するための血流予備量比値算出ユニットと、
放射源によって生成される放射であって、造影剤が大動脈を流れる間に生物の大動脈を横断している放射に基づいて検出器によって経時的に生成されている投影データを提供するための投影データ提供ユニットであって、前記検出器は投影データを生成するために使用される数行の検出素子を有し、前記放射源により、前記検出素子の全ての行が照射されないが、単一の扇形ビームによって1行のみが照射されるか、又は幾つかの扇形ビームによって数行が照射される、投影データ提供ユニットと、
提供される前記投影データに基づいて生物固有の境界条件を算出するための境界条件算出ユニットと
を含む、機器。 - 前記投影データ提供ユニットが、放射に基づいて前記検出器によって経時的に生成されている扇形ビーム投影データを提供し、当該放射は、前記放射源によって生成され、且つ造影剤が様々な位置のうちの或る位置から様々な位置のうちの別の位置に大動脈を流れる間、それらの様々な位置において大動脈を横断しており、前記境界条件算出ユニットは、提供される前記投影データに基づいて境界条件を算出する、請求項1に記載の機器。
- 前記表現提供ユニットは、異なる位置間の大動脈を示す大動脈表現を更に提供し、前記境界条件算出ユニットは、前記提供される投影データ及び前記大動脈表現に基づいて境界条件を算出する、請求項2に記載の機器。
- 前記境界条件算出ユニットは、冠動脈系及び冠動脈系の血管を取り囲む周囲領域を示す画像を前記提供される投影データに基づいて経時的に再構築し、且つ前記画像に基づいて冠動脈系を去る血液量を境界条件として算出する、請求項1に記載の機器。
- 前記境界条件算出ユニットは、周囲領域を示す画像要素の画像値に基づいて冠動脈系を去る血液量を算出する、請求項4に記載の機器。
- 前記境界条件算出ユニットは、周囲領域を示す画像要素の画像値に基づいて心筋組織内の造影剤の一部の取込みを示す心筋組織値を算出し、且つ心筋組織値に基づいて冠動脈系を去る血液量を算出する、請求項5に記載の機器。
- 前記境界条件算出ユニットは、周囲領域を示す画像要素の画像値に基づいて周囲領域を示す何れの画像要素が、冠動脈系の提供される表現によって表わされるには小さ過ぎる冠動脈系の血管の側枝を表すかを明らかにし、且つ明らかにされた画像要素に基づいて側枝経由で冠動脈系を去る血液量を算出する、請求項5に記載の機器。
- 前記境界条件算出ユニットは、境界条件として冠動脈系の出口における冠動脈の流速及び/又は大きさを決定する、請求項1に記載の機器。
- 生物の解剖学的及び/又は生理学的特性を与えるための特性提供ユニットを更に含み、前記境界条件算出ユニットは、生物の提供される特性に基づいて境界条件を算出する、請求項1に記載の機器。
- 前記特性提供ユニットは、冠動脈系の血管の断面積、心筋質量、冠動脈系の血管及びその枝の口径比、心臓の大きさ、心臓の駆出率、並びに/又は心臓の一回拍出量を特性として提供する、請求項9に記載の機器。
- 前記血流予備量比値算出ユニットは、冠動脈系内の流量を表す集中型モデルに基づく血流予備量比値算出アルゴリズムを使用し、前記境界条件算出ユニットは、境界条件として集中型モデルのパラメータを算出する、請求項1に記載の機器。
- 生物の冠動脈系の血流予備量比値を算出するための方法であって、前記方法は、
冠動脈系の表現を表現提供ユニットによって与えるステップと、
境界条件及び提供される前記冠動脈系の表現に基づいて血流予備量比値を算出する血流予備量比値算出アルゴリズムを使用することにより、血流予備量比値算出ユニットによって血流予備量比値を算出するステップと、
放射源によって生成され、且つ造影剤が大動脈を流れる間に生物の大動脈を横断している放射に基づいて検出器によって経時的に生成されている投影データを投影データ提供ユニットによって提供するステップであって、前記検出器は投影データを生成するために使用される数行の検出素子を有し、前記放射源により、前記検出素子の全ての行が照射されないが、単一の扇形ビームによって1行のみが照射されるか、又は幾つかの扇形ビームによって数行が照射される、ステップと、
提供される前記投影データに基づいて生物固有の境界条件を境界条件算出ユニットによって算出するステップと
を含む、方法。 - 生物の冠動脈系のFFR値を算出するためのコンピュータプログラムであって、前記コンピュータプログラムは、機器を制御するコンピュータ上で実行されるとき、請求項12に記載の方法のステップを請求項1に記載の機器に行わせるためのプログラムコード手段を含む、コンピュータプログラム。
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