WO2015189712A2 - Silicone-based biophotonic compositions and uses thereof - Google Patents

Silicone-based biophotonic compositions and uses thereof Download PDF

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Publication number
WO2015189712A2
WO2015189712A2 PCT/IB2015/001761 IB2015001761W WO2015189712A2 WO 2015189712 A2 WO2015189712 A2 WO 2015189712A2 IB 2015001761 W IB2015001761 W IB 2015001761W WO 2015189712 A2 WO2015189712 A2 WO 2015189712A2
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WO
WIPO (PCT)
Prior art keywords
composition
silicone
chromophore
surfactant
phase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2015/001761
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English (en)
French (fr)
Other versions
WO2015189712A3 (en
Inventor
Remigio Piergallini
Nikolaos Loupis
Joanna Jaworska
Emmanuelle DEVEMY
Eric Desrosiers
Abdellatif Chenite
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Klox Technologies Inc
Original Assignee
Klox Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Klox Technologies Inc filed Critical Klox Technologies Inc
Priority to CA2951513A priority Critical patent/CA2951513A1/en
Priority to AU2015273123A priority patent/AU2015273123A1/en
Priority to US15/317,316 priority patent/US11266685B2/en
Priority to JP2016572259A priority patent/JP7017311B2/ja
Priority to EP15806945.0A priority patent/EP3151861B1/en
Priority to CN201580030942.7A priority patent/CN106573055B/zh
Publication of WO2015189712A2 publication Critical patent/WO2015189712A2/en
Publication of WO2015189712A3 publication Critical patent/WO2015189712A3/en
Anticipated expiration legal-status Critical
Priority to AU2020257072A priority patent/AU2020257072A1/en
Ceased legal-status Critical Current

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    • A61K31/33—Heterocyclic compounds
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    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
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Definitions

  • Figure 3 illustrates the light emission spectra of the membrane of Figure 1 during 10-15 minutes of illumination.
  • the chromophore may be present in an amount of about 0.001-40% per weight of the composition or of the surfactant phase. In certain embodiments, the at least one chromophore is present in an amount of about 0.001-3%, 0.001-0.01%, 0.005-0.1%, 0.1- 0.5%, 0.5-2%, 1-5%, 2.5-7.5%, 5-10%, 7.5-12.5%, 10-15%, 12.5-17.5%, 15-20%, 17.5- 22.5%, 20-25%, 22.5-27.5%, 25-30%, 27.5-32.5%, 30-35%, 32.5-37.5%, or 35-40% per weight of the silicone -based biophotonic composition or of the surfactant phase.
  • the second chromophore may be present in an amount of about 0.001- 40% per weight of the silicone-based biophotonic composition or of the surfactant phase. In certain embodiments, the second chromophore is present in an amount of about 0.001- 3%, 0.001-0.01%, 0.005-0.1%, 0.1-0.5%, 0.5-2%, 1-5%, 2.5-7.5%, 5-10%, 7.5-12.5%, 10-15%, 12.5-17.5%, 15-20%, 17.5-22.5%, 20-25%, 22.5-27.5%, 25-30%, 27.5-32.5%, 30-35%), 32.5-37.5%), or 35-40%) per weight of the silicone-based biophotonic composition or of the surfactant phase.
  • Exemplary methylene blue derivatives include but are not limited to 1 -methyl methylene blue; 1,9-dimethyl methylene blue; methylene blue; methylene violet; bromomethylene violet; 4-iodomethylene violet; l,9-dimethyl-3-dimethyl-amino-7-diethyl-amino- phenothiazine; and l,9-dimethyl-3-diethylamino-7-dibutyl-amino-phenot- hiazine.
  • Azo dyes include but are not limited to 1 -methyl methylene blue; 1,9-dimethyl methylene blue; methylene blue; methylene violet; bromomethylene violet; 4-iodomethylene violet; l,9-dimethyl-3-dimethyl-amino-7-diethyl-amino- phenothiazine; and l,9-dimethyl-3-diethylamino-7-dibutyl-amino-phen
  • Exemplary azo (or diazo-) dyes include but are not limited to methyl violet, neutral red, para red (pigment red 1), amaranth (Azorubine S), Carmoisine (azorubine, food red 3, acid red 14), allura red AC (FD&C 40), tartrazine (FD&C Yellow 5), orange G (acid orange 10), Ponceau 4R (food red 7), methyl red (acid red 2), and murexide-ammonium purpurate.
  • the one or more chromophores of the silicone-based biophotonic compositions disclosed herein can be independently selected from any of Acid black 1, Acid blue 22, Acid blue 93, Acid fuchsin, Acid green, Acid green 1, Acid green 5, Acid magenta, Acid orange 10, Acid red 26, Acid red 29, Acid red 44, Acid red 51, Acid red 66, Acid red 87, Acid red 91, Acid red 92, Acid red 94, Acid red 101, Acid red 103, Acid roseine, Acid rubin, Acid violet 19, Acid yellow 1, Acid yellow 9, Acid yellow 23, Acid yellow 24, Acid yellow 36, Acid yellow 73, Acid yellow S, Acridine orange, Acriflavine, Alcian blue, Alcian yellow, Alcohol soluble eosin, Alizarin, Alizarin blue 2RC, Alizarin carmine, Alizarin cyanin BBS, Alizarol cyanin R, Alizarin red S, Alizarin purpurin, Aluminon, Amido black 10B, Amidoschwarz, Aniline blue WS
  • trichloromethylthioimides that can be used in the disclosure include, but are not limited to: N-(trichloromethylthio)phthalimide, which is sold under the tradename Fungitrol®; and N-trichloromethylthio-4-cyclohexene-l,2-dicarboximide, which is sold under the tradename Vancide®.
  • silicone-based biophotonic compositions of the present disclosure are substantially transparent or translucent.
  • the % transmittance of the silicone-based biophotonic composition can be measured in the range of wavelengths from 250 nm to 800 nm using, for example, a Perkin-Elmer Lambda 9500 series UV- visible spectrophotometer. In some embodiments, transmittance within the visible range is measured and averaged. In some other embodiments, transmittance of the silicone- based biophotonic composition is measured with the chromophore omitted. As transmittance is dependent upon thickness, the thickness of each sample can be measured with calipers prior to loading in the spectrophotometer. Transmittance values can be normalized according to
  • the mask (or patch) is not pre-formed and is applied e.g., by spreading a silicone-based biophotonic composition making up the mask (or patch), on the skin or target tissue, or alternatively by smearing, dabbing or rolling the composition on target tissue. It can then be converted to a peel-off form after application, by means such as, but not limited to, drying or inducing a change in temperature upon application to the skin or tissue. After use, the mask (or patch) can then be peeled off without leaving any flakes on the skin or tissue, preferably without wiping or washing.
  • the silicone-based biophotonic composition has an adhesion strength that is less than its tensile strength or its tear strength.
  • the present disclosure provides a method for providing skin rejuvenation or for improving skin condition, treating a skin disorder, preventing or treating scarring, and/or accelerating wound healing and/or tissue repair, the method comprising: applying a silicone-based biophotonic composition of the present disclosure to the area of the skin or tissue in need of treatment, and illuminating the silicone-based biophotonic composition with light having a wavelength that overlaps with an absorption spectrum of the chromophore(s) present in the composition.
  • the silicone-based biophotonic composition may be used following ablative skin rejuvenation treatment to maintain the condition of the treated skin.
  • the silicone-based biophotonic composition may be applied at regular intervals such as once a week, or at an interval deemed appropriate by the physician.
  • Expression wrinkles result from a loss of resilience, particularly in the dermis, because of which the skin is no longer able to resume its original state when facial muscles which produce facial expressions.
  • vitamin C examples include an ascorbic acid derivative such as L-ascorbic acid or sodium L-ascorbate, an ascorbic acid preparation obtained by coating ascorbic acid with an emulsifier or the like, and a mixture containing two or more of those vitamin Cs at an arbitrary rate.
  • natural products containing vitamin C such as acerola or lemon may also be used.
  • the silicone-based biophotonic compositions and methods of the present disclosure can be used to treat one or more of skin irritation, pitting, development of scars, comedones, inflammatory papules, cysts, hyperkeratinazation, and thickening and hardening of sebum associated with acne.
  • the kit may further comprise a light source such as a portable light with a wavelength appropriate to activate the chromophore of the silicone- based biophotonic composition.
  • a light source such as a portable light with a wavelength appropriate to activate the chromophore of the silicone- based biophotonic composition.
  • the portable light may be battery operated or re- chargeable.

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CA2951513A CA2951513A1 (en) 2014-06-09 2015-06-09 Silicone-based biophotonic compositions and uses thereof
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US15/317,316 US11266685B2 (en) 2014-06-09 2015-06-09 Silicone-based biophotonic compositions and uses thereof
JP2016572259A JP7017311B2 (ja) 2014-06-09 2015-06-09 シリコンベースの生体光組成物およびその使用
EP15806945.0A EP3151861B1 (en) 2014-06-09 2015-06-09 Silicone-based biophotonic compositions and uses thereof
CN201580030942.7A CN106573055B (zh) 2014-06-09 2015-06-09 基于硅酮的生物光子组合物及其用途
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WO2018053641A1 (en) * 2016-09-23 2018-03-29 Klox Technologies Inc. Biophotonic compositions and methods for reducing scarring
WO2019041032A1 (en) * 2017-08-28 2019-03-07 Klox Technologies Inc. BIOPHOTONIC SILICONE MEMBRANES FOR THE TREATMENT OF SCARS
WO2019095072A1 (en) * 2017-11-17 2019-05-23 Klox Technologies Limited Biophotonic compositions, methods and kits for enhancing hair growth
WO2021003568A1 (en) * 2019-07-08 2021-01-14 Klox Technologies Inc. Inert polymer-coated biophotonic systems

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EP3151861A4 (en) 2017-12-13
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CN106573055B (zh) 2021-03-23
AU2020257072A1 (en) 2020-11-19
AR101656A1 (es) 2017-01-04
EP3151861A2 (en) 2017-04-12
EP3151861B1 (en) 2022-04-06
US20170209484A1 (en) 2017-07-27
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CA2951513A1 (en) 2015-12-17
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