WO2015178015A1 - Composition for removing color of blood - Google Patents

Abstract

As a composition for use in the prevention of the formation of blood stains on an article or the removal of blood stains adhered onto an article, a composition for removing the color of blood is provided, which contains serotonin. It is preferred that the composition for removing the color of blood additionally contains iron ions.

Description

Blood discoloring composition

The present invention relates to a blood decoloring composition. More specifically, the present invention relates to a blood decoloring composition used for preventing the formation of blood stains on an article or removing blood stains attached to an article, and a composition containing serotonin.

Blood stains attached to textiles are very difficult to remove. Blood stains that have dried and adhered firmly to the fibers after the blood has adhered are particularly problematic in sheets, wrapping cloths, lab coats, and surgical clothes used in hotels and hospitals. Blood stains are usually washed first with water, and then washed at a high temperature of 60 to 80 ° C. using a detergent, an alkaline agent and a bleaching agent in combination.

Patent Document 1 describes a method for cleaning a blood-contaminated cloth using a surfactant, which includes a preliminary cleaning process and a main cleaning process. When a strong surfactant is used, discoloration of the textile product may occur. In this regard, Patent Document 2 describes a cleaning agent using natto and koji as a cleaning agent that can cleanly remove blood stains without using a surfactant.

JP 2002-138300 A Japanese Patent Laid-Open No. 10-46196

The main object of the present invention is to provide a composition capable of easily or effectively preventing or removing blood stains.

In order to solve the above problems, the present invention provides the following [1] to [9].
[1] A composition for decoloring blood, containing serotonin.
[2] The blood decoloring composition according to [1], further comprising iron.
[3] The blood decoloring composition according to [1] or [2], which is a soap.

[4] A fiber product coated, impregnated or mixed with the blood decoloring composition according to [1] or [2].
[5] The textile product according to [4], which is a brush for an underwear, a sanitary napkin, toilet paper, a sheet, a wrapping cloth, a lab coat, a surgical gown, or a cleaning instrument.

[6] A method for removing blood stains on a textile product, the method comprising contacting the blood stain with a blood decoloring composition containing serotonin.
[7] A method for preventing blood stains on a textile product, the method comprising a step of applying, impregnating or mixing a textile product with a blood decoloring composition containing serotonin.
[8] A method for producing a textile product, comprising a step of applying, impregnating or mixing a textile product with a blood decoloring composition containing serotonin.
[9] The method according to any one of [6] to [8], wherein the textile product is underwear, sanitary napkin, toilet paper, sheets, wrapping cloth, lab coat, surgical gown, or brush of a cleaning instrument.

According to the present invention, there is provided a blood decoloring composition capable of easily or effectively preventing or removing blood stains.

It is a photograph which shows the result of having wash | cleaned the cotton cloth which made the blood adhere and sun-dried for two weeks using the blood decoloring composition. It is a photograph which shows the result of having washed the cotton cloth which made blood adhere and sun-dried for two months using the blood decoloring composition. It is a photograph which shows the result of having wash | cleaned the cotton cloth which made blood adhere and was stored at room temperature for 36 hours using the blood decoloring composition. It is a photograph which shows the result of having made blood adhere to the cotton fabric previously processed with the blood decoloring composition.

Hereinafter, preferred embodiments for carrying out the present invention will be described. In addition, embodiment described below shows an example of typical embodiment of this invention, and, thereby, the range of this invention is not interpreted narrowly.

The blood decoloring composition according to the present invention is characterized by containing serotonin and iron. The composition for decoloring blood according to the present invention may contain a surfactant, but even if it does not contain a surfactant, it can effectively prevent or remove blood stains. Moreover, in the blood decoloring composition according to the present invention, the color fading of an article with blood stains hardly occurs.

Serotonin may be a synthetic compound or a naturally derived compound.

When a synthetic compound is used, it can be synthesized using a known method described in the literature (for example, see Life Sci., 2014, Vol.97, No.1, p.20-26).

When natural compounds are used, they can be obtained in plant extracts. The plant from which serotonin can be extracted is not particularly limited, but sunflower, coffee beans, onion, long onion, spinach, lettuce, chisha, chicory, Chinese cabbage, licorice, pineapple, banana, tomato, cucumber, mucuna grass, strawberry, cherry, Plums, grapes, papayas, genus peas, soybeans, rain tree genus plants, peas, hamar genus plants, peanuts, almonds, cacao beans, acacias, maracilla plants, plums, eggplants, nettles, gush genus plants , Pumpkin, pepper, potato, corn, broccoli, pumpkin, sweet potato, peppermint, berry leaf, walnut, lemon, cedar, bergamot, lamb, vanilla grass, ginkgo, ginseng, ginseng, herb genus (commonly called herbs plant Generic), sesame, hemp, flax, cotton seed, bitter gourd, watermelon, Kakinegarashi, pepper, rice, brown rice, wheat, barley, Lonicera caerulea, ascetic garlic, such as carrots and burdock, and the like. These plants are known to contain serotonin. Further, the extraction site of the plant is not particularly limited, but may be leaves, stems, roots, flowers, seeds, fruits, and skins thereof. In addition, serotonin is also contained in seaweeds such as kelp, seaweed and mozuku, and serotonin can be obtained from these. In particular, sunflower seeds, tomato skin, mozuku, seaweed, and the like are preferable because they contain a large amount of serotonin and are easy to obtain and extract.

The amount of serotonin in the composition is not particularly limited, but is 50 pM to 10 nM, preferably 100 pM to 5 nM. It is considered that serotonin extracts iron ions from heme iron by chelating action against iron ions and decolorizes heme iron (reddish brown) in blood stains.

Iron may be included in an ionic state or in a salt state. The iron ion may be divalent or trivalent iron. Iron can be added to the composition in the form of iron hydroxide, acid iron or iron chloride.

The amount of iron in the composition is not particularly limited, but is 0.1 to 5.0 mg / L. It is considered that iron is coordinated with serotonin and enhances the stability of serotonin in the composition.

The blood decoloring composition according to the present invention may be solid (for example, soap), liquid, or semi-solid such as gel or cream. The solid composition can be produced by a conventionally known cold process production method (see Production Example 1). Moreover, a liquid composition can be manufactured by re-dissolving a solid composition in water etc., for example. The composition for decoloring blood stains according to the present invention may optionally contain a surfactant such as an anionic surfactant, a cationic surfactant and an amphoteric surfactant. Moreover, the component conventionally mix | blended with soap and liquid detergent can be mix | blended.

The blood decoloring composition according to the present invention can be decolored and removed by bringing the blood decoloring composition into contact with blood stains attached to the article. For example, a liquid blood decoloring composition is applied to or sprayed on the blood stains of the article, and then left to rest. Alternatively, a solid or semi-solid blood decoloring composition may be rubbed or applied to the site of the article to which blood stains have adhered, and then left to rest.

Furthermore, the blood decoloring composition according to the present invention may be preliminarily applied, impregnated or mixed with an article, thereby preventing blood stains from occurring when blood adheres to the article. For example, an article having a blood stain preventing function can be produced by applying or impregnating a liquid blood decoloring composition to an article or a material (for example, fiber) constituting the article. Alternatively, an article having a function of preventing blood stains can be produced by mixing a liquid, solid, or semi-solid blood decoloring composition with a material (for example, fiber) constituting the article.

In the present invention, an article that is a target for removing or preventing blood stains is not particularly limited. For example, a textile product is a suitable example. Examples of the textile products include underwear, sanitary napkins, toilet paper, sheets, wrapping cloths, lab coats, surgical clothes, and brushes for cleaning instruments such as vacuum cleaners, brooms, and mops.

The composition for decoloring blood according to the present invention can be used for washing clothes and textiles with blood stains in hospitals, pharmacies, homes and the like. Moreover, the blood stain of a medical device can also be prevented by previously applying, impregnating or mixing the blood decoloring composition according to the present invention to the medical device. For example, if it is a resin-made syringe, it can also mix with resin before shaping | molding besides apply | coating the composition for blood decoloring which concerns on this invention. Furthermore, the blood discoloring composition according to the present invention may be used by a road administrator or the police for removing blood stains when blood stains adhere to a road or road installation due to a traffic accident or the like. it can.

<Production Example 1: Production of solid detergent>
A solid blood decoloring composition (soap) was produced by the following procedure.

1. Preparation of Serotonin Extract 1) Commercially available sunflower seeds (variety name: Miracle Beam) were pulverized in physiological saline (500 ml / 100 seeds).
2) A commercially available tomato (mini tomato) was boiled for about 20 minutes with physiological saline at 37 ° C., and then only the skin was collected. The skin was finely cut with scissors and then ground in physiological saline (500 ml / skin 5 g).
3) Commercial mozuku and seaweed (total 30 g) were mixed in a mortar until viscosity was generated.
4) The pulverized product and admixture of 1) to 3) above were mixed (mixed solution A).
5) The mixed solution A was immersed in a thermostat adjusted to 30 ° C. and gently aerated for about 18 hours.
6) Subsequently, the mixed solution A was immersed in a thermostat adjusted to 38 ° C. and left to stand for about 6 hours.
7) Commercial coffee beans were pulverized in physiological saline (500 ml / 50 seeds) and added to the mixture A (mixture B).
8) The mixed solution B was immersed in a thermostat adjusted to 23 ° C. and shaken for about 24 hours.
9) Subsequently, the mixed solution B was immersed in a thermostat adjusted to 38 ° C. and aerated for about 44 hours.
10) Further, the mixed solution B was immersed in a thermostatic bath adjusted to 35 ° C. and allowed to stand for about 12 hours.
11) The supernatant was dispensed into the bottle (1) and aerated at room temperature for 18 hours.
12) A 1/4 amount of supernatant was collected in the bottle (2) from the bottle (1) and allowed to stand at room temperature for 18 hours.
13) 1/2 amount of the supernatant was collected from the bottle (2) into the bottle (3) and aerated at room temperature for 18 hours.
14) A 1/4 amount of the supernatant was collected in the bottle (4) from the bottle (3) and allowed to stand at room temperature for 18 hours.
15) The supernatant was dispensed into the bottle (5) and allowed to stand for 24 hours in a thermostat adjusted to 40 ° C.
16) The solution of 15) was dropped into a column packed with Sepharose particles, and the column passage liquid from 2 minutes to 7 minutes after the initial dropping was recovered.
17) The column-passed solution was filtered (double filtration, the first stage filter paper was 0.1 μm, the second stage filter paper was 0.05 μm, and the third stage filter paper was 0.025 μm), and stored in a sterile container at room temperature.

2. Production of blood decoloring composition 1) The serotonin extract obtained above and water were mixed, sodium hydroxide was added and stirred.
2) Subsequently, cananol oil was added and stirred. The mass ratio of each component was canola oil: sodium hydroxide: serotonin extract: water = 1: 0.15: 0.3: 0.2.
3) After pouring into a casting_mold | template, it was left still for about one month in a 13 degreeC thermostat, and it was set as the solid composition.

<Production Example 2: Production of liquid detergent>
A liquid blood decoloring composition was produced by the following procedure.
1) 20 times amount (mass ratio) of water was mixed with the solid composition obtained above to obtain a liquid composition.

<Example 1: Evaluation of dirt removal effect>
The removal effect of blood stain was evaluated for the soap of Production Example 1 and a commercially available cleaning agent. Pure whip (Kao Corporation) was used as a commercially available cleaning agent.

The blood was adhered to the cotton cloth and dried in the sun for 2 weeks to completely fix the blood. After washing with water, it was washed with the soap of Production Example 1 or a commercially available detergent.

The results are shown in FIG. (A) is sun-dried, (B) is washed with water, (C) is washed with a commercially available detergent (pure whip), (D) is blood-bonded cotton cloth after washing with soap according to the present invention. Indicates the part. Blood stains remained after washing with water and washing with a commercially available detergent. On the other hand, in the washing with the soap of the present invention, blood stains almost completely disappeared, and the color of the cloth did not fade. Moreover, the stain removal effect by the soap of the present invention was confirmed even when used in combination with a commercially available cleaning agent.

Similarly, the test was conducted by changing the sun drying period after attaching blood to the cotton cloth to one week. As a result, in the soap according to the present invention, it was possible to confirm an excellent dirt removing effect as compared with a commercially available cleaning agent.

<Example 2: Evaluation of dirt removal effect>
The removal effect of blood stain was evaluated for the soap of Production Example 1, the liquid detergent of Production Example 2 and a commercially available cleaning agent. Sarasati lingerie detergent (Kobayashi Pharmaceutical Co., Ltd.) was used as a commercially available detergent. This commercial detergent is weakly alkaline and contains a surfactant (40% sodium alkyl sulfonate (SAS), polyoxyethylene alkyl ether, sodium alkyl sulfate ester).

The blood was adhered to the cotton cloth and dried in the sun for 2 months to completely fix the blood. The soap of Production Example 1, the liquid detergent of Production Example 2, and a commercially available cleaning agent were also washed and compared with washing with water.

The results are shown in FIG. (A) after washing with water, (B) after washing with a commercially available detergent (Sasarati Lingerie detergent), (C) after washing with soap of Production Example 1, and (D) Production Example 2. The blood adhering part of the cotton cloth after the fir washing with the liquid detergent is shown. Blood stains remained after washing with water and washing with a commercially available detergent. On the other hand, the fouling with the soap and liquid detergent of the present invention was able to remove blood stains almost completely.

Further, after blood was adhered to a cotton cloth, the test was conducted by storing at room temperature for 36 hours without drying in the sun. The results are shown in FIG. (A) shows the blood adhering portion of the cotton cloth after 36-hour storage at room temperature, and (B) after scrubbing with the liquid detergent of Production Example 2. The fouling with the liquid detergent of the present invention could completely remove blood stains.

Similarly, the test was performed by changing the room temperature storage period after blood was adhered to the cotton cloth to 12 hours. As a result, in the liquid detergent according to the present invention, it was possible to confirm an excellent dirt removing effect as compared with a commercially available cleaning agent. In addition, the effect of removing dirt by the liquid detergent of the present invention was confirmed even when a rigid fiber (shoe) was used instead of cotton cloth.

<Example 3: Evaluation of antifouling effect>
The liquid detergent of Production Example 2 and a commercially available cleaning agent were evaluated for the effect of preventing blood stains. The liquid detergent of Production Example 2 was used without being diluted or diluted with 10 times (mass ratio) of water. Commercially available detergents include Soapama Honpo Co., Ltd. Soap Bubble Sunor Pure Soap (commercial product 1), Sarasati Lingerie's detergent (commercial product 2), and Azuma Industry Co., Ltd. A commercial product 3) was used. The commercial product 1 contains a cosmetic soap base (fatty acid sodium) composed of beef tallow and palm kernel fat. The commercial product 3 is weakly alkaline and contains a surfactant (polyoxyethylene alkyl ether, sodium alkyl sulfate ester, pure soap (fatty acid sodium)).

Six test areas of cotton cloth were divided, and 0.5 ml of the liquid detergent of Production Example 2 and any one of commercially available products 1 to 3 was applied to each area and dried. For comparison, water was applied to one of the areas (control). 1 g of blood was dropped on each region, and a cotton cloth was left to observe the formation of blood stains.

The results are shown in FIG. (A) shows the test area immediately after dropping the blood, (B) shows the test area after 15 minutes, and (C) shows the test area after 3 hours. In the region treated with the liquid detergent of Production Example 2, coloring by blood was prevented 15 minutes and 3 hours after dropping of blood, and the effect of preventing the formation of blood stains was confirmed.

<Test Example 1: Component analysis of plant extract>
The serotonin extract prepared in Production Example 1 was fractionated using a liquid chromatograph, and the components were analyzed. The serotonin extract contained serotonin and iron. The serotonin extract contained about 100 pM serotonin and about 0.5 mg / L iron ions.

Claims (7)

1. A composition for blood decoloration containing serotonin.
2. The blood decoloring composition according to claim 1, further comprising iron.
3. The composition for decoloring blood according to claim 1 or 2, which is a soap.
4. A textile product obtained by coating, impregnating or mixing the blood decoloring composition according to claim 1 or 2.
5. A method for removing blood stains from a textile product, the method comprising contacting a blood stain with a blood decoloring composition containing serotonin.
6. A method for preventing blood stains on a textile product, comprising a step of applying, impregnating or mixing a textile product with a blood decoloring composition containing serotonin.
7. A method for producing a textile product, the method comprising a step of applying, impregnating or mixing a textile product with a blood decoloring composition containing serotonin.

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