WO2015169898A1 - Process for the production of 2,6-dimethylbenzoquinone - Google Patents
Process for the production of 2,6-dimethylbenzoquinone Download PDFInfo
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- WO2015169898A1 WO2015169898A1 PCT/EP2015/060063 EP2015060063W WO2015169898A1 WO 2015169898 A1 WO2015169898 A1 WO 2015169898A1 EP 2015060063 W EP2015060063 W EP 2015060063W WO 2015169898 A1 WO2015169898 A1 WO 2015169898A1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C46/00—Preparation of quinones
- C07C46/02—Preparation of quinones by oxidation giving rise to quinoid structures
- C07C46/06—Preparation of quinones by oxidation giving rise to quinoid structures of at least one hydroxy group on a six-membered aromatic ring
- C07C46/08—Preparation of quinones by oxidation giving rise to quinoid structures of at least one hydroxy group on a six-membered aromatic ring with molecular oxygen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
Definitions
- the present invention relates to an improved process for the production of 2,6- dimethylbenzoquinone (2,6-DMQ).
- 2,6-DMQ is used for example in the synthesis of Vitamin E.
- JP 2006-249036 a method for the manufacture of 2,3,5-trimehtlyhydroquinone is disclosed.
- 2,6-dimethylphenol is oxidised with 0 2 in the presence of a Cu(l) or Cu(ll) compound.
- the amount of the Cu compound is between 0.01 to 0.02 mol-equivalent (mol-eq). This process still produces significant amounts of side-products.
- the present invention relates to a process (I) for the production of 2,6- dimethylbenzoquinone, wherein 2,6-dimethylphenol is oxidised by O2 in the presence of at least 0.4 mol-eq, based on the mol of 2,6-dimethylphenol, of at least one copper salt.
- the increased amount of at least one copper salt leads to a process with an excellent yield and selectivity of 2,6-dimethylbenzoquinone. That means that the amount of side products (dimer formation) is surprisingly decreased dramatically.
- the present invention also relates to a process ( ⁇ ), which is process (I), wherein the at least one copper salt is a Cu(ll) salt. Therefore the present invention also relates to a process (II"), which is process (I), wherein the copper salt is CuC .
- the at least one copper salt (preferably Cu(ll) salt, more preferably CuCI 2 ) is used in amount of at least 0.4 mol-eq, based on the mol of 2,6-dimethylphenol.
- Preferred is a process, wherein 0.4 to 2 mol-eq, more preferably up to 1 .8 mol-eq, of at least one copper salt is used.
- the present invention also relates to a process (III), which is process (I), (II), (II') or (II"), wherein the at least one copper salt is used in an amount of at least 0.4 mol-eq, based on the mol of 2,6-dimethylphenol.
- the present invention also relates to a process (I II'), which is process (I), (II), ( ⁇ ) or (II"), wherein the at least one copper salt is used in an amount of 0.4 to 2 mol-%, based on the mol of 2,6-dimethylphenol.
- the present invention also relates to a process (III"), which is process (I), (II), ( ⁇ ) or (II"), wherein the at least one salt compound is used in amount of 0.4 to 1 .8 mol-eq, based on the mol of 2,6-dimethylphenol.
- the copper salt (catalyst) can be reused.
- the process according to the present invention is usually carried out at a temperature of from 50°C to 95°C, preferably from 60°C to 85°C, more preferably from 70 to 85°C, most preferably from 70 to 80°C.
- the present invention also relates to a process (IV), which is process (I), (II), ( ⁇ ), (II"), (III), (III * ) or (III"), wherein the process is carried out at a temperature of from 50°C to 95°C.
- the present invention also relates to a process (IV), which is process (I), (II), ( ⁇ '), (II"), (III), (III') or (III"), wherein the process is carried out at a temperature of from 60°C to 85°C. Therefore the present invention also relates to a process (IV"), which is process (I), (II), ( ⁇ ), (II"), (III), (III') or (III"), wherein the process is carried out at a temperature of from 70 to 85°C.
- the present invention also relates to a process (IV"), which is process (I), (II), ( ⁇ '), (II"), (III), (III') or (III"), wherein the process is carried out at a temperature of from 70 to 80°C.
- the process according to the present invention is usually carried out in an inert sol- vent (or mixture of solvents), the solvent can be non-polar or polar.
- the solvent (or the mixture of solvents) has to be liquid at the reaction conditions (temperature, pressure) of the process according to the present invention.
- Suitable solvents are alkylene carbonates and glycol ethers.
- Preferred solvents are ethylene carbonates and methyl diethylene glycol (MDG).
- the present invention also relates to a process (V), which is process (I), (II), ( ⁇ '), (II"), (III), (III'), (III"), (IV), (IV), (IV") or (IV"), wherein the process is carried out in an inert solvent (or mixture of solvents). Therefore the present invention also relates to a process (V), which is process (I), (II), ( ⁇ '), (II"), (III), (III'), (III"), (IV), (IV), (IV”) or (IV"), wherein the process is carried out at in at least one solvent chosen from the group consisting of alkylene carbonates and glycol ethers.
- the present invention also relates to a process (V"), which is process (I), (II), ( ⁇ '), (II"), (III), (III'), (III"), (IV), (IV), (IV") or (IV"), wherein the process is carried out at in at least one solvent chosen from the group consisting of ethylene carbonates and methyl diethylene glycol (MDG).
- the oxidation process according to the present invention can be carried out with pure O2 gas as well as with a gas mixture containing O2 gas (such as air). Preferred is pure 0 2 gas.
- the present invention also relates to a process (VI), which is process (I), (II), ( ⁇ '), (II"), (III), (III'), (III"), (IV), (IV), (IV"), (IV"), (V), (V) or (V), wherein the process is carried with gas mixture containing O 2 gas. Therefore the present invention also relates to a process (VI'), which is process (VI), wherein the gas is air.
- the present invention also relates to a process (VI"), which is process (I), (II), ( ⁇ '), (II"), (III), (III'), (III"), (IV), (IV), (IV), (V), (V) or (V"), wherein the process is carried with pure O 2 .
- O 2 or air is induced directly into the liquid reaction mixture.
- the flow rate of the oxygen can vary. The flow rate is dependent on the size of the reaction apparatus.
- the present invention also relates to a process (VII), which is process (I), (II), ( ⁇ '), (II"), (III), (III'), (III"), (IV), (IV), (IV"), (IV"), (V), (V), (V) (VI), (VI') or (VI"), wherein (Vcontaining gas is induced directly into the liquid reaction mixture.
- the so obtained 2,6-DMQ can be isolated using commonly known methods or it can be used without isolation for further reactions.
- 2,6-DMQ can be used as starting material in organic synthesis.
- 2,6- DMQ can be used to form 2,3,5-trimethylhydroquinone (TMHQ), which is then reacted with (all-rac)-isophytol to obtain (all-rac)-a-tocopherol.
- TMHQ 2,3,5-trimethylhydroquinone
- Example 1 A solution of 4.10 g of CuC1 ⁇ 2 x 2H 2 0 in 8.4 ml of methyl diethyl glycol (MDG) was added into a flask. The solution was heated to 75°C and O2 was introduced (30 ml/min) into the solution and the solution was stirred.
- MDG methyl diethyl glycol
- the amount of CUCI2 x 2H 2 0 was 1 .2 mol-eq (in regard to the starting material). After the addition of the 2,6-DMP, the reaction mixture was stirred for another hour. Afterwards the obtained product (2,6-DMQ) was isolated.
- the yield was 81 % and the conversion was >99.9% and the selectivity was 81 %.
- Example 2 The procedure as described in Example 1 was repeated, but the O2 flow was in- creased to 60 ml/min.
- the yield was 84% and the conversion was >99.9 % and the selectivity was 84%.
- Example 3 Comparison Example The procedure as described in Example 1 was repeated, but the amount of CuC x 2H 2 0 was reduced to 0.68 g. which are 0.2 mol-eq.
- the yield was 49% and the conversion was >99.9 % and the selectivity was 49%. It can be seen that a low amount of CuCI 2 x 2H 2 O results in lower selectivity.
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The present invention relates to an improved process for the production of 2,6-dimethylbenzoquinone (2,6-DMQ) by oxidation of 2,6-dimethylphenol with oxygen in the presence of a copper salt.
Description
PROCESS FOR THE PRODUCTION OF 2,6-DIMETHYLBENZOQUINONE
The present invention relates to an improved process for the production of 2,6- dimethylbenzoquinone (2,6-DMQ).
2,6-dimethylbenzoquinone (2,6-DMQ), which is the compound of formula (A),
is an important and widely used compound in organic synthesis. 2,6-DMQ is used for example in the synthesis of Vitamin E.
Many processes for the production of 2,6-DMQ are known from the prior art. But many of them do have the issues with the yield and the selectivity of 2,6,-DMQ. Es- pecially the forming of side products during the reaction (i.e. dimer forming) is a problem.
In JP 2006-249036 a method for the manufacture of 2,3,5-trimehtlyhydroquinone is disclosed. As a reaction step in this process 2,6-dimethylphenol is oxidised with 02 in the presence of a Cu(l) or Cu(ll) compound. The amount of the Cu compound is between 0.01 to 0.02 mol-equivalent (mol-eq). This process still produces significant amounts of side-products.
Therefore the goal of the present invention was to find a process for the production of 2,6-DMQ, wherein an excellent yield and selectivity is achieved.
Surprisingly, it was found out that the 2,6-dimethylphenol (2,6-DMP), which is the compound (B)
can be oxidised with O2 in the presence of a high amount of a copper salt (as a catalyst) in better selectivity.
It is surprising that the increase of the amount of the catalyst has a positive impact on the selectivity.
Therefore, the present invention relates to a process (I) for the production of 2,6- dimethylbenzoquinone, wherein 2,6-dimethylphenol is oxidised by O2 in the presence of at least 0.4 mol-eq, based on the mol of 2,6-dimethylphenol, of at least one copper salt.
The increased amount of at least one copper salt (in comparison the Japanese patent application 2006-249036) leads to a process with an excellent yield and selectivity of 2,6-dimethylbenzoquinone. That means that the amount of side products (dimer formation) is surprisingly decreased dramatically.
The copper salt is preferably at least one Cu(l) salt and/or at least one Cu(ll) salt, more preferred at least one Cu(ll) salt. Most preferred is CuC^ (this salt usually has crystal water= CuCl2x2H20, so the this form is also covered by the term CuCI2 ). Therefore the present invention also relates to a process (II), which is a process (I), wherein the at least one copper salt is a Cu(l) salt and/or Cu(ll) salt.
Therefore the present invention also relates to a process (ΙΓ), which is process (I), wherein the at least one copper salt is a Cu(ll) salt.
Therefore the present invention also relates to a process (II"), which is process (I), wherein the copper salt is CuC .
The at least one copper salt (preferably Cu(ll) salt, more preferably CuCI2) is used in amount of at least 0.4 mol-eq, based on the mol of 2,6-dimethylphenol.
Preferred is a process, wherein 0.4 to 2 mol-eq, more preferably up to 1 .8 mol-eq, of at least one copper salt is used.
Therefore the present invention also relates to a process (III), which is process (I), (II), (II') or (II"), wherein the at least one copper salt is used in an amount of at least 0.4 mol-eq, based on the mol of 2,6-dimethylphenol.
Therefore the present invention also relates to a process (I II'), which is process (I), (II), (ΙΓ) or (II"), wherein the at least one copper salt is used in an amount of 0.4 to 2 mol-%, based on the mol of 2,6-dimethylphenol.
Therefore the present invention also relates to a process (III"), which is process (I), (II), (ΙΓ) or (II"), wherein the at least one salt compound is used in amount of 0.4 to 1 .8 mol-eq, based on the mol of 2,6-dimethylphenol.
The copper salt (catalyst) can be reused.
The process according to the present invention is usually carried out at a temperature of from 50°C to 95°C, preferably from 60°C to 85°C, more preferably from 70 to 85°C, most preferably from 70 to 80°C.
Therefore the present invention also relates to a process (IV), which is process (I), (II), (ΙΓ), (II"), (III), (III*) or (III"), wherein the process is carried out at a temperature of from 50°C to 95°C.
Therefore the present invention also relates to a process (IV), which is process (I), (II), (ΙΙ'), (II"), (III), (III') or (III"), wherein the process is carried out at a temperature of from 60°C to 85°C.
Therefore the present invention also relates to a process (IV"), which is process (I), (II), (ΙΓ), (II"), (III), (III') or (III"), wherein the process is carried out at a temperature of from 70 to 85°C. Therefore the present invention also relates to a process (IV"), which is process (I), (II), (ΙΙ'), (II"), (III), (III') or (III"), wherein the process is carried out at a temperature of from 70 to 80°C.
The process according to the present invention is usually carried out in an inert sol- vent (or mixture of solvents), the solvent can be non-polar or polar. The solvent (or the mixture of solvents) has to be liquid at the reaction conditions (temperature, pressure) of the process according to the present invention. Suitable solvents are alkylene carbonates and glycol ethers.
Preferred solvents are ethylene carbonates and methyl diethylene glycol (MDG).
Therefore the present invention also relates to a process (V), which is process (I), (II), (ΙΙ'), (II"), (III), (III'), (III"), (IV), (IV), (IV") or (IV"), wherein the process is carried out in an inert solvent (or mixture of solvents). Therefore the present invention also relates to a process (V), which is process (I), (II), (ΙΙ'), (II"), (III), (III'), (III"), (IV), (IV), (IV") or (IV"), wherein the process is carried out at in at least one solvent chosen from the group consisting of alkylene carbonates and glycol ethers. Therefore the present invention also relates to a process (V"), which is process (I), (II), (ΙΙ'), (II"), (III), (III'), (III"), (IV), (IV), (IV") or (IV"), wherein the process is carried out at in at least one solvent chosen from the group consisting of ethylene carbonates and methyl diethylene glycol (MDG). The oxidation process according to the present invention can be carried out with pure O2 gas as well as with a gas mixture containing O2 gas (such as air). Preferred is pure 02 gas.
Therefore the present invention also relates to a process (VI), which is process (I), (II), (ΙΙ'), (II"), (III), (III'), (III"), (IV), (IV), (IV"), (IV"), (V), (V) or (V), wherein the process is carried with gas mixture containing O2 gas. Therefore the present invention also relates to a process (VI'), which is process (VI), wherein the gas is air.
Therefore the present invention also relates to a process (VI"), which is process (I), (II), (ΙΙ'), (II"), (III), (III'), (III"), (IV), (IV), (IV), (V), (V) or (V"), wherein the process is carried with pure O2.
In a preferred embodiment O2 or air is induced directly into the liquid reaction mixture.
The flow rate of the oxygen can vary. The flow rate is dependent on the size of the reaction apparatus.
Therefore the present invention also relates to a process (VII), which is process (I), (II), (ΙΙ'), (II"), (III), (III'), (III"), (IV), (IV), (IV"), (IV"), (V), (V), (V) (VI), (VI') or (VI"), wherein (Vcontaining gas is induced directly into the liquid reaction mixture.
The so obtained 2,6-DMQ can be isolated using commonly known methods or it can be used without isolation for further reactions.
2,6-DMQ can be used as starting material in organic synthesis. For example, 2,6- DMQ can be used to form 2,3,5-trimethylhydroquinone (TMHQ), which is then reacted with (all-rac)-isophytol to obtain (all-rac)-a-tocopherol.
The following examples serve to illustrate the invention. The temperature is given in degree Celsius.
Examples
Example 1 A solution of 4.10 g of CuC½ x 2H20 in 8.4 ml of methyl diethyl glycol (MDG) was added into a flask. The solution was heated to 75°C and O2 was introduced (30 ml/min) into the solution and the solution was stirred.
A solution of 2.49 g (20 mmol) of 2,6-DMP in 8.4 ml of MDG was added slowly to the catalyst solution. The addition time of the DMP was about 3 hours.
The amount of CUCI2 x 2H20 was 1 .2 mol-eq (in regard to the starting material). After the addition of the 2,6-DMP, the reaction mixture was stirred for another hour. Afterwards the obtained product (2,6-DMQ) was isolated.
The yield was 81 % and the conversion was >99.9% and the selectivity was 81 %.
Example 2
The procedure as described in Example 1 was repeated, but the O2 flow was in- creased to 60 ml/min.
The yield was 84% and the conversion was >99.9 % and the selectivity was 84%.
Example 3 (Comparison Example) The procedure as described in Example 1 was repeated, but the amount of CuC x 2H20 was reduced to 0.68 g. which are 0.2 mol-eq.
The yield was 49% and the conversion was >99.9 % and the selectivity was 49%. It can be seen that a low amount of CuCI2 x 2H2O results in lower selectivity.
Claims
1. A process for the production of 2,6-dimethylbenzoquinone, wherein 2,6- dimethylphenol is oxidised by O2 in the presence of at least 0.4 mol-eq, based on the mol of 2,6-dimethylphenol, of at least one copper salt.
2. Process according to claim 1 , wherein the at least copper salt is a Cu(l) and/or Cu(ll) salt.
3. Process according to claim 1 , wherein the at least copper salt is a Cu(ll) salt.
4. Process according to claim 1 , wherein the copper salt is CuC .
5. Process according to any of the preceding claims, wherein the at least copper salt is used in an amount of 0.4 to 2 mol-eq.
6. Process according to any of the preceding claims, wherein the process is carried out at a temperature of from 50°C to 95°C, preferably from 60°C to 85°C, more preferably from 70 to 85°C, most preferably from 70 to 80°C.
7. Process according to any of the preceding claims, wherein the process is carried out at in an inert solvent (or mixture of solvents).
8. Process according to claim 7, wherein the solvent (or mixtures of solvents) is chosen from the group consisting of alkylene carbonates and glycol ethers.
9. Process according to any of the preceding claims, wherein the process is carried with a gas containing O2 gas.
10. Process according to claim 7, wherein the gas is air.
11. Process according to any of the preceding claims 1 - 8, wherein the process is carried with pure O2.
Process according to any of the preceding claims 1 - 8, wherein the pure 02 gas or the 02-containing gas is induced directly into the liquid reaction mixture.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EA201692246A EA035035B1 (en) | 2014-05-09 | 2015-05-07 | Process for the production of 2,6-dimethylbenzoquinone |
CN201580023802.7A CN106458820A (en) | 2014-05-09 | 2015-05-07 | Process for the production of 2,6-dimethylbenzoquinone |
EP15721227.5A EP3140273A1 (en) | 2014-05-09 | 2015-05-07 | Process for the production of 2,6-dimethylbenzoquinone |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP14167752 | 2014-05-09 | ||
EP14167752.6 | 2014-05-09 | ||
EP14198910 | 2014-12-18 | ||
EP14198910.3 | 2014-12-18 |
Publications (1)
Publication Number | Publication Date |
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WO2015169898A1 true WO2015169898A1 (en) | 2015-11-12 |
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PCT/EP2015/060063 WO2015169898A1 (en) | 2014-05-09 | 2015-05-07 | Process for the production of 2,6-dimethylbenzoquinone |
Country Status (4)
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EP (1) | EP3140273A1 (en) |
CN (1) | CN106458820A (en) |
EA (1) | EA035035B1 (en) |
WO (1) | WO2015169898A1 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2019201820A1 (en) | 2018-04-17 | 2019-10-24 | Dsm Ip Assets B.V. | Oxidation of alkylated p-hydroquinones in aqueous solutions by hydrogen peroxide |
WO2019201819A1 (en) | 2018-04-17 | 2019-10-24 | Dsm Ip Assets B.V. | Oxidation of alkylated p-hydroquinones in aqueous solutions by oxygen |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2021122437A1 (en) * | 2019-12-19 | 2021-06-24 | Dsm Ip Assets B.V. | Formation of 2,3,5-trimethylhydroquinone from 2,3,6-trimethylphenol |
Citations (6)
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US3796732A (en) * | 1971-05-17 | 1974-03-12 | Hoffmann La Roche | Process for oxidizing phenols to quinones |
JPS5093931A (en) * | 1973-12-22 | 1975-07-26 | ||
US3987068A (en) * | 1975-07-28 | 1976-10-19 | E. I. Du Pont De Nemours And Company | Oxidation of monohydroxy aryl compounds to 1,4-quinones |
JPS62148446A (en) * | 1985-12-23 | 1987-07-02 | Mitsui Toatsu Chem Inc | Production of quinone compound |
JPH0381249A (en) * | 1989-08-23 | 1991-04-05 | Agency Of Ind Science & Technol | Production of 2,6-dimethyl-p-benzoquinone |
JP2006249036A (en) * | 2005-03-14 | 2006-09-21 | Honshu Chem Ind Co Ltd | Method for producing 2, 3, 5-trimethylhydroquinone |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050137409A1 (en) * | 2003-12-18 | 2005-06-23 | Sunil Ashtekar | Processes for preparing benzoquinones and hydroquinones |
US20050137380A1 (en) * | 2003-12-18 | 2005-06-23 | Mahalingam Rathinam J. | Processes for preparing benzoquinones and hydroquinones |
CN102336643B (en) * | 2011-07-13 | 2014-06-25 | 北京博源恒升高科技有限公司 | Process for synthesizing benzoquinones by direct oxidation of phenols |
-
2015
- 2015-05-07 EP EP15721227.5A patent/EP3140273A1/en not_active Withdrawn
- 2015-05-07 WO PCT/EP2015/060063 patent/WO2015169898A1/en active Application Filing
- 2015-05-07 CN CN201580023802.7A patent/CN106458820A/en active Pending
- 2015-05-07 EA EA201692246A patent/EA035035B1/en not_active IP Right Cessation
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US3796732A (en) * | 1971-05-17 | 1974-03-12 | Hoffmann La Roche | Process for oxidizing phenols to quinones |
JPS5093931A (en) * | 1973-12-22 | 1975-07-26 | ||
US3987068A (en) * | 1975-07-28 | 1976-10-19 | E. I. Du Pont De Nemours And Company | Oxidation of monohydroxy aryl compounds to 1,4-quinones |
JPS62148446A (en) * | 1985-12-23 | 1987-07-02 | Mitsui Toatsu Chem Inc | Production of quinone compound |
JPH0381249A (en) * | 1989-08-23 | 1991-04-05 | Agency Of Ind Science & Technol | Production of 2,6-dimethyl-p-benzoquinone |
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Non-Patent Citations (10)
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DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; KOMIYAMA, TADASHI ET AL: "Quinones", XP002730354, retrieved from STN Database accession no. 1988:221407 * |
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See also references of EP3140273A1 * |
SHIMIZU, M. ET AL.: "SYNTHESIS OF ALKYL SUBSTUTED P-BENZOQUINONES FROM THE CORRESPONDINGPHENOLS USING MOLECULAR OXYGEN CATALYZED BY COPPER(II) CHLORIDE-AMINE HYDROCHLORIDE SYSTEMS", BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, vol. 65, no. 6, 1992, pages 1522 - 1526, XP001005330, ISSN: 0009-2673 * |
TAKAKI, K. ET AL.: "Selective oxidation of phenols to hydroxybenzaldehydes and benzoquinones with dioxygen catalyzed by polymer-supported copper", BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, vol. 75, no. 2, 2002, pages 311 - 317, XP009180422, ISSN: 0009-2673 * |
TAKEHIRA, K. ET AL.: "Novel oxidation of phenols by a copper(II) complex catalyst/oxygen system", STUDIES IN SURFACE SCIENCE AND CATALYSIS, vol. 66, 1991, pages 279 - 284, XP009180425, ISSN: 0167-2991 * |
TAKIZAWA, Y. ET AL.: "Novel oxidative coupling of monophenols in the system of cupric chloride-oxygen-alcohol", THE JOURNAL OF ORGANIC CHEMISTRY, vol. 50, no. 22, 1985, pages 4383 - 4386, XP055143011, ISSN: 0022-3263, DOI: 10.1021/jo00222a038 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2019201820A1 (en) | 2018-04-17 | 2019-10-24 | Dsm Ip Assets B.V. | Oxidation of alkylated p-hydroquinones in aqueous solutions by hydrogen peroxide |
WO2019201819A1 (en) | 2018-04-17 | 2019-10-24 | Dsm Ip Assets B.V. | Oxidation of alkylated p-hydroquinones in aqueous solutions by oxygen |
Also Published As
Publication number | Publication date |
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EP3140273A1 (en) | 2017-03-15 |
EA035035B1 (en) | 2020-04-20 |
CN106458820A (en) | 2017-02-22 |
EA201692246A1 (en) | 2017-04-28 |
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