WO2015167257A1 - Composition pour application buccale et son procédé de préparation - Google Patents
Composition pour application buccale et son procédé de préparation Download PDFInfo
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- WO2015167257A1 WO2015167257A1 PCT/KR2015/004343 KR2015004343W WO2015167257A1 WO 2015167257 A1 WO2015167257 A1 WO 2015167257A1 KR 2015004343 W KR2015004343 W KR 2015004343W WO 2015167257 A1 WO2015167257 A1 WO 2015167257A1
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- Prior art keywords
- composition
- oral application
- clause
- acid
- lewis
- Prior art date
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- 239000000203 mixture Substances 0.000 title claims abstract description 110
- 238000000034 method Methods 0.000 title claims abstract description 21
- 239000002841 Lewis acid Substances 0.000 claims abstract description 56
- 150000007517 lewis acids Chemical class 0.000 claims abstract description 56
- 239000002879 Lewis base Substances 0.000 claims abstract description 47
- 150000007527 lewis bases Chemical class 0.000 claims abstract description 47
- 150000001875 compounds Chemical class 0.000 claims abstract description 25
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 54
- LNTHITQWFMADLM-UHFFFAOYSA-N gallic acid Chemical compound OC(=O)C1=CC(O)=C(O)C(O)=C1 LNTHITQWFMADLM-UHFFFAOYSA-N 0.000 claims description 52
- TUSDEZXZIZRFGC-UHFFFAOYSA-N 1-O-galloyl-3,6-(R)-HHDP-beta-D-glucose Natural products OC1C(O2)COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC1C(O)C2OC(=O)C1=CC(O)=C(O)C(O)=C1 TUSDEZXZIZRFGC-UHFFFAOYSA-N 0.000 claims description 30
- 239000001263 FEMA 3042 Substances 0.000 claims description 30
- LRBQNJMCXXYXIU-PPKXGCFTSA-N Penta-digallate-beta-D-glucose Natural products OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-PPKXGCFTSA-N 0.000 claims description 30
- 235000015523 tannic acid Nutrition 0.000 claims description 30
- 229920002258 tannic acid Polymers 0.000 claims description 30
- LRBQNJMCXXYXIU-NRMVVENXSA-N tannic acid Chemical compound OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-NRMVVENXSA-N 0.000 claims description 30
- 229940033123 tannic acid Drugs 0.000 claims description 30
- 210000005239 tubule Anatomy 0.000 claims description 28
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 26
- XEEYBQQBJWHFJM-UHFFFAOYSA-N iron Substances [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 26
- 235000004515 gallic acid Nutrition 0.000 claims description 25
- 229940074391 gallic acid Drugs 0.000 claims description 25
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 claims description 22
- 239000010410 layer Substances 0.000 claims description 22
- 239000011247 coating layer Substances 0.000 claims description 21
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims description 19
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims description 19
- 150000002500 ions Chemical class 0.000 claims description 17
- 210000000214 mouth Anatomy 0.000 claims description 17
- 239000002245 particle Substances 0.000 claims description 17
- 238000000576 coating method Methods 0.000 claims description 13
- 239000000243 solution Substances 0.000 claims description 13
- 239000004408 titanium dioxide Substances 0.000 claims description 13
- 239000011248 coating agent Substances 0.000 claims description 12
- 229910052712 strontium Inorganic materials 0.000 claims description 12
- ODINCKMPIJJUCX-UHFFFAOYSA-N Calcium oxide Chemical compound [Ca]=O ODINCKMPIJJUCX-UHFFFAOYSA-N 0.000 claims description 11
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims description 11
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 claims description 11
- 238000006243 chemical reaction Methods 0.000 claims description 11
- HDMKAUUMGFGBRJ-UHFFFAOYSA-N iron;dihydrate Chemical compound O.O.[Fe] HDMKAUUMGFGBRJ-UHFFFAOYSA-N 0.000 claims description 11
- 238000004519 manufacturing process Methods 0.000 claims description 11
- 229910052710 silicon Inorganic materials 0.000 claims description 11
- 239000010703 silicon Substances 0.000 claims description 11
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 claims description 11
- 229910052742 iron Inorganic materials 0.000 claims description 10
- CWYNVVGOOAEACU-UHFFFAOYSA-N Fe2+ Chemical compound [Fe+2] CWYNVVGOOAEACU-UHFFFAOYSA-N 0.000 claims description 8
- 239000011347 resin Substances 0.000 claims description 7
- 229920005989 resin Polymers 0.000 claims description 7
- 238000007789 sealing Methods 0.000 claims description 7
- 238000009472 formulation Methods 0.000 claims description 4
- 239000000443 aerosol Substances 0.000 claims description 3
- 239000006072 paste Substances 0.000 claims description 3
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 claims 2
- VTLYFUHAOXGGBS-UHFFFAOYSA-N Fe3+ Chemical compound [Fe+3] VTLYFUHAOXGGBS-UHFFFAOYSA-N 0.000 claims 2
- KJNGJIPPQOFCSK-UHFFFAOYSA-N [H][Sr][H] Chemical compound [H][Sr][H] KJNGJIPPQOFCSK-UHFFFAOYSA-N 0.000 claims 2
- 208000024891 symptom Diseases 0.000 abstract description 17
- 201000002170 dentin sensitivity Diseases 0.000 abstract description 5
- 230000036347 tooth sensitivity Effects 0.000 abstract 3
- 210000004268 dentin Anatomy 0.000 description 20
- 239000007864 aqueous solution Substances 0.000 description 18
- -1 iron (III) ions Chemical class 0.000 description 18
- 238000001878 scanning electron micrograph Methods 0.000 description 18
- 230000008859 change Effects 0.000 description 12
- 239000000377 silicon dioxide Substances 0.000 description 12
- 230000001680 brushing effect Effects 0.000 description 10
- 239000011575 calcium Substances 0.000 description 10
- 210000003298 dental enamel Anatomy 0.000 description 10
- 239000002105 nanoparticle Substances 0.000 description 10
- CIOAGBVUUVVLOB-UHFFFAOYSA-N strontium atom Chemical compound [Sr] CIOAGBVUUVVLOB-UHFFFAOYSA-N 0.000 description 10
- 150000004696 coordination complex Chemical class 0.000 description 9
- 238000002156 mixing Methods 0.000 description 8
- 239000000120 Artificial Saliva Substances 0.000 description 7
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 7
- 239000002253 acid Substances 0.000 description 7
- 239000006185 dispersion Substances 0.000 description 7
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 7
- 239000000463 material Substances 0.000 description 7
- 239000011574 phosphorus Substances 0.000 description 7
- 229910052698 phosphorus Inorganic materials 0.000 description 7
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 6
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 229910052791 calcium Inorganic materials 0.000 description 6
- 229920001864 tannin Polymers 0.000 description 6
- 235000018553 tannin Nutrition 0.000 description 6
- 239000001648 tannin Substances 0.000 description 6
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 6
- 239000004568 cement Substances 0.000 description 5
- 238000000724 energy-dispersive X-ray spectrum Methods 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- 230000002087 whitening effect Effects 0.000 description 5
- VZSRBBMJRBPUNF-UHFFFAOYSA-N 2-(2,3-dihydro-1H-inden-2-ylamino)-N-[3-oxo-3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propyl]pyrimidine-5-carboxamide Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)C(=O)NCCC(N1CC2=C(CC1)NN=N2)=O VZSRBBMJRBPUNF-UHFFFAOYSA-N 0.000 description 4
- 208000004381 Uterine cervical erosion Diseases 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 4
- 238000004132 cross linking Methods 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 239000003446 ligand Substances 0.000 description 4
- 239000000606 toothpaste Substances 0.000 description 4
- 229940034610 toothpaste Drugs 0.000 description 4
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 3
- 229910019142 PO4 Inorganic materials 0.000 description 3
- 208000002925 dental caries Diseases 0.000 description 3
- 238000000151 deposition Methods 0.000 description 3
- 239000012153 distilled water Substances 0.000 description 3
- 229910021645 metal ion Inorganic materials 0.000 description 3
- 210000005036 nerve Anatomy 0.000 description 3
- 208000028169 periodontal disease Diseases 0.000 description 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 3
- 239000010452 phosphate Substances 0.000 description 3
- 150000008442 polyphenolic compounds Chemical class 0.000 description 3
- 235000013824 polyphenols Nutrition 0.000 description 3
- 229910000160 potassium phosphate Inorganic materials 0.000 description 3
- 235000011009 potassium phosphates Nutrition 0.000 description 3
- 239000011780 sodium chloride Substances 0.000 description 3
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 210000000988 bone and bone Anatomy 0.000 description 2
- 239000000920 calcium hydroxide Substances 0.000 description 2
- 229910001861 calcium hydroxide Inorganic materials 0.000 description 2
- 239000000292 calcium oxide Substances 0.000 description 2
- BRPQOXSCLDDYGP-UHFFFAOYSA-N calcium oxide Chemical compound [O-2].[Ca+2] BRPQOXSCLDDYGP-UHFFFAOYSA-N 0.000 description 2
- HZPFSLFWWBLHHN-UHFFFAOYSA-N calcium;silver Chemical compound [Ca+2].[Ag+] HZPFSLFWWBLHHN-UHFFFAOYSA-N 0.000 description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 2
- 238000000586 desensitisation Methods 0.000 description 2
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 2
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000011737 fluorine Substances 0.000 description 2
- 229910052731 fluorine Inorganic materials 0.000 description 2
- 125000000524 functional group Chemical group 0.000 description 2
- 230000014509 gene expression Effects 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 2
- 238000007654 immersion Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 239000002674 ointment Substances 0.000 description 2
- 201000001245 periodontitis Diseases 0.000 description 2
- 239000008055 phosphate buffer solution Substances 0.000 description 2
- 239000002953 phosphate buffered saline Substances 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 229910001414 potassium ion Inorganic materials 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 239000006188 syrup Substances 0.000 description 2
- 235000020357 syrup Nutrition 0.000 description 2
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 1
- 244000205574 Acorus calamus Species 0.000 description 1
- 235000011996 Calamus deerratus Nutrition 0.000 description 1
- 235000014036 Castanea Nutrition 0.000 description 1
- 241001070941 Castanea Species 0.000 description 1
- 235000011511 Diospyros Nutrition 0.000 description 1
- 241000723267 Diospyros Species 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 102000029749 Microtubule Human genes 0.000 description 1
- 108091022875 Microtubule Proteins 0.000 description 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
- 206010039509 Scab Diseases 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- 239000007983 Tris buffer Substances 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 241000219094 Vitaceae Species 0.000 description 1
- 229930013930 alkaloid Natural products 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- XITRBUPOXXBIJN-UHFFFAOYSA-N bis(2,2,6,6-tetramethylpiperidin-4-yl) decanedioate Chemical compound C1C(C)(C)NC(C)(C)CC1OC(=O)CCCCCCCCC(=O)OC1CC(C)(C)NC(C)(C)C1 XITRBUPOXXBIJN-UHFFFAOYSA-N 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- 239000013522 chelant Substances 0.000 description 1
- 230000001055 chewing effect Effects 0.000 description 1
- VDQQXEISLMTGAB-UHFFFAOYSA-N chloramine T Chemical compound [Na+].CC1=CC=C(S(=O)(=O)[N-]Cl)C=C1 VDQQXEISLMTGAB-UHFFFAOYSA-N 0.000 description 1
- 230000001010 compromised effect Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 229910003460 diamond Inorganic materials 0.000 description 1
- 239000010432 diamond Substances 0.000 description 1
- 238000002845 discoloration Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229960003638 dopamine Drugs 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- 150000002215 flavonoids Chemical class 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 208000024693 gingival disease Diseases 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 235000021021 grapes Nutrition 0.000 description 1
- 235000009569 green tea Nutrition 0.000 description 1
- 235000021059 hard food Nutrition 0.000 description 1
- GPRLSGONYQIRFK-UHFFFAOYSA-N hydron Chemical compound [H+] GPRLSGONYQIRFK-UHFFFAOYSA-N 0.000 description 1
- FBAFATDZDUQKNH-UHFFFAOYSA-M iron chloride Chemical compound [Cl-].[Fe] FBAFATDZDUQKNH-UHFFFAOYSA-M 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 210000004688 microtubule Anatomy 0.000 description 1
- 229940031182 nanoparticles iron oxide Drugs 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 235000006408 oxalic acid Nutrition 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 210000002379 periodontal ligament Anatomy 0.000 description 1
- 229920001690 polydopamine Polymers 0.000 description 1
- 239000002952 polymeric resin Substances 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 239000011775 sodium fluoride Substances 0.000 description 1
- 235000013024 sodium fluoride Nutrition 0.000 description 1
- 229910001415 sodium ion Inorganic materials 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 229910001427 strontium ion Inorganic materials 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 230000005062 synaptic transmission Effects 0.000 description 1
- 229920003002 synthetic resin Polymers 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/26—Iron; Compounds thereof
Definitions
- composition for oral application and its manufacturing method
- the present invention relates to a composition for oral application and a method for producing the same, and more particularly, to a composition for oral application comprising a Lewis base and Lewis acid of a specific component and a method for producing the same.
- Dental tissue is composed of enamel, cement and dentin.
- the outermost part of the exposed part of the tooth is covered with enamel, and the outer part of the root of the tooth located in the alveolar bone is covered with cement and dentin is enclosed by enamel and cement.
- microtubules called dental tubles are distributed throughout the dentin.
- the main causes of ache are known cervical abrasion cervical abfracture due to dental caries, windworms (periodontal disease, periodontitis, periodon titis) and incorrect brushing.
- Tooth decay occurs mainly on the chewing side of the tooth, or on the adjacent side between the tooth and the tooth, which destroys the enamel surrounding the dentin, which exposes the dentin and the dentin tubules, causing the tooth to feel cold.
- This stratified disease is mainly associated with age groups where enamel is not sufficiently strengthened in infancy and adolescence.
- the periodontal disease known as gum disease, is caused by damage to the periodontal ligaments that connect teeth and alveolar bones. Exposed, the teeth feel ache.
- the periodontal disease is mainly seen in adults after the 30s, most of which is insensitive to the reality.
- Cervical abrasion (cervical abfracture) is mainly caused by poor brushing, and cervical abrasion is the most common cause of cervical abrasion.
- Enamel or cement which is the outer membrane surrounding the dentin in the cervical region, is very thin. If there is a habit of brushing from side to side with strong force while brushing or enjoying hard food, the enamel or cement of the cervical region may be affected by external stimulation. Damaged, exposed dentin and dentinal tubules, the teeth feel ache symptoms ⁇
- Hydrodynamic theory is widely accepted that as the flow of dentin flows, external stimuli are transferred to the pulp, causing pain.
- the pulp nerve desensitization is a treatment to artificially increase the content of potassium ions by controlling the neurotransmission by the proper ratio of sodium ions and potassium ions, thereby preventing the nerves from feeling pain.
- Topical fluorine coating, oxalic acid-based coating, resin coating, and the like are mainly used as a treatment for applying exposed ivory tubules with other materials to prevent exposure to external stimuli.
- the ivory capillary sealing method is frequently performed in the dentistry, and thus, studies on various coating materials having excellent durability, human safety, and ease of application are needed.
- the present invention is to provide a composition for oral application excellent in durability, human safety, and ease of application and a method for producing the same.
- the present invention is selected from the group comprising tannic acid (galnic acid) and gallic acid (gallic acid)
- At least one Lewis base At least one Lewis base; And iron (II) ions, iron (III) ions, strontium (III) ions, calcium (II) ions, titanium dioxide (Ti0 2 ), iron oxide (Fe 2 0 3 ), iron hydroxide (Fe (OH) 2 ) It provides a composition for oral application, comprising at least one Lewis acid selected from the group consisting of calcium oxide (CaO), calcium hydroxide (Ca (OH) 2 ), silicon (Si), and silica (Si0 2 ). .
- Lewis acid selected from the group consisting of calcium oxide (CaO), calcium hydroxide (Ca (OH) 2 ), silicon (Si), and silica (Si0 2 ).
- At least some of the Lewis base and Lewis acid may be present in the form of a complex in which the Lewis base is coordinated with the Lewis acid.
- the complex compound may include one or more selected from the group consisting of a coordination complex, a 4 coordination complex, and a 6 coordination complex.
- composition may comprise the Lewis base and the Lewis acid in a concentration of about 0.01 mg / ml to about lmg / ml, respectively, in the composition.
- the Lewis base and the Lewis acid may be included in a molar ratio of 0.5: 1 to 10: 1.
- the composition may have a pH value in the range of about 3 to about 8.
- the composition may further comprise silica particles, it may be preferable that the silica particles have a number average particle diameter of about 0.05;
- the above-described composition may have various forms of formulation such as solution, paste, aerosol, or resin.
- the present invention is one or more Lewis base selected from the group comprising tannic acid (galnic acid) and gallic acid (gallic acid); And iron ( ⁇ ) ions, iron (III) ions, strontium (III) ions, calcium ( ⁇ ) ions, titanium dioxide (Ti0 2 ), iron oxide (Fe 2 0 3 ), iron hydroxide (Fe (OH) 2 )
- the Lewis base and the Lewis acid may be reacted in a molar ratio of about 0.5: 1 to about 10: 1.
- the reaction may be preferably performed at a pH of about 3 to about 8, and may be preferably performed under a temperature range of 4 to 60 ° C and a pressure range of about 0.1 to about 5 atm.
- the complex of the Lewis base and the Lewis acid may further comprise the step of coating the silica particles.
- composition for oral application of the present invention is excellent in durability, human safety, and ease of application, and can be effectively applied inside the oral cavity, which can alleviate or treat the symptom of the syrup, and, when the syrup is applied before the symptom appears, This symptom can be prevented.
- 1 is an SEM image observed at different magnifications for various surfaces of a dental specimen.
- Figure 3 is an SEM image observed at different magnification for the surface of the dental specimen treated with the composition according to an embodiment of the present invention.
- Figure 4 is an SEM image observed by varying the magnification for various cross-sections of the dental specimen treated with the composition according to an embodiment of the present invention.
- Figure 5 is an SEM image observed before and after the treatment of the composition according to an embodiment of the tooth specimen on the surface of the dental specimen.
- FIG. 6 is an SEM image of a composition including ordinary silica particles and silica particles according to an embodiment of the present invention.
- Figure 7 shows the EDX spectrum on the surface of the tooth specimen after treatment with the composition according to an embodiment of the present invention.
- FIG. 9 is an SEM image of the front and cross sections of a dental specimen before and after treatment of the composition according to an embodiment of the present invention.
- 10 is an SEM image of the front and the cross-section of the tooth specimen before and after the treatment of the composition according to an embodiment of the present invention.
- Figure 11 is an SEM image of the front and cross-section of the tooth specimen before and after the treatment of the composition according to an embodiment of the present invention.
- Oral application composition of the present invention comprises at least one Lewis base selected from the group comprising tannic acid (tannic acid) and gallic acid (gallic acid); And iron (II) ions, iron (III) ions, strontium (III) ions, calcium (II) silver, titanium dioxide (Ti0 2 ), iron oxide (Fe 2 0 3 ), iron hydroxide (Fe (OH) 2 ), at least one Lewis acid selected from the group consisting of calcium oxide (CaO), calcium hydroxide (Ca (OH) 2 ), silicon (Si), and silica (Si0 2 ).
- Lewis base selected from the group comprising tannic acid (tannic acid) and gallic acid (gallic acid);
- the method for preparing a composition for oral application of the present invention comprises at least one Lewis base selected from the group comprising tannic acid and gallic acid; And iron (II) ions, iron (III) ions, strontium ( ⁇ ) ions, calcium (II) ions, titanium dioxide (Ti0 2 ), iron oxide (Fe 2 0 3 ), iron hydroxide (Fe (OH) 2 ) Reacting at least one Lewis Sanol selected from the group comprising calcium oxide (CaO), calcium hydroxide (Ca (OH) 2 ), silicon (Si), and silica (Si0 2 ).
- Lewis base selected from the group comprising tannic acid and gallic acid
- each layer or element when each layer or element is referred to as being formed “on” or “on” of each layer or element, it means that each layer or element is formed directly on each layer or element, or It is meant that a layer or element can additionally be formed between each layer, on the object, the substrate.
- Oral application composition comprises at least one Lewis base selected from the group comprising tannic acid (tannic acid) and gallic acid (gallic acid); And iron (II) ions, iron (III) ions, strontium (III) ions, calcium (II) silver, titanium dioxide (Ti0 2 ), iron oxide (Fe 2 0 3 ), iron hydroxide (Fe (OH) 2 ), at least one Lewis acid selected from the group consisting of calcium oxide (CaO), calcium hydroxide (Ca (OH) 2 ), silicon (Si), and silica (Si0 2 ).
- Lewis base selected from the group comprising tannic acid (tannic acid) and gallic acid (gallic acid);
- at least one Lewis acid selected from the
- At least some of the above-described Lewis base and Lewis acid may be present in the form of a complex in which the Lewis base is coordinated with the Lewis acid.
- fluorine or resin is applied locally to prevent the exposure of dentin tubules.
- polydopamine is used to remove damaged enamel layer. Research has been conducted on how to promote regeneration.
- Tannin acid is a kind of natural polyphenol synthesized in various plants and may have a structure of the following formula.
- the molecular structure of tannic acid is not limited thereto, and may exist in the form of various polymers having various functional groups.
- Gallic acid is also a non-flavonoid family of natural antioxidants and can be structurally represented as 3,4,5-trihydroxybenzoic acid, but in its natural state it is present in the form of various forms of polymers or polyphenols. can do. Tannic acid and gallic acid, as can be seen in the structure described above,
- the galloyl group present in tannic acid or gallic acid can act as a Lewis base, due to the non-covalent electron pairs abundant in the hydroxyl group or the carboxy group, and can be used as iron (II) ions, iron (III) ions, Strontium (III) ions, chalc ( ⁇ ) ions, titanium dioxide (Ti0 2 ), iron oxide (Fe 2 0 3 ), iron hydroxide (Fe (OH) 2 ), chame oxide (CaO), calcium hydroxide (Ca (OH 2 ), silicon (Si), and silica (Si0 2 ) to form coordination bonds with various forms of Lewis acids to form stable complexes such as octahedral structures.
- each galloyl group can form a cross link around a different Lewis acid, it forms a rigid bond similar to that of a polymer resin, and thus can be easily bonded to the tooth surface. .
- the complex compound coordinated with Lewis base to Lewis acid which may be present in the composition may be Since a coating layer can be formed on the surface and the dentinal tubule can be effectively blocked, the virus can effectively prevent or alleviate the symptoms.
- the above-described complex is about 10 nm to about 1 thick on the surface of the damaged tooth
- the coating layer may be formed to a thickness of about 20 nm to about 500 nm, thereby effectively sealing the ivory tubule having a diameter of about 0.5 to about 2 ⁇ .
- the saliva and calcium and phosphorus components contained in the tooth surface can be easily deposited on the complex coating layer due to the many functional groups present inside the tannic acid or gallic acid molecules, which causes the hydroxyapatite layer to be described above. It can be easily formed on the coating layer.
- Tannic acid or gallic acid is present in a large amount in natural foods such as grapes, persimmons, chestnuts, acorns, green tea, and the like, and is a polyphenol material that has been absorbed by the human body for thousands of years.
- Tannic acid or gallic acid can be easily obtained as a natural product, and industrially, wood can be easily extracted from the remaining bark and the like, so the price is also very excellent.
- a molecule of tannic acid or gallic acid or a small unit of the above-mentioned complex compound molecules is adsorbed onto the surface of the tooth, followed by other tannic acid or gallic acid molecules, the Lewis acid material described above, or While forming cross linking with the complex molecule, a coating layer is formed on the surface of the tooth.
- the complex of the Lewis base and the Lewis acid may include one or more selected from the group consisting of a double coordination complex, a fourth coordination complex, and a six coordination complex.
- the coordination complex (mono-complex) is a Lewis base in Lewis acid as described above.
- a bi-complex complex means that four hydroxyl groups of the Lewis bases described above are coordinated with Lewis acid to form a ligand.
- 6 coordination complex tris-complex means that six hydroxyl groups of Lewis bases mentioned above are coordinated with Lewis acid to form a ligand.
- Lewis (I) ions iron (III) ions, strontium (III) ions, and / or calcium (II) ions are used as Lewis acids, these metal ions may become central metals to form complexes.
- Silica (Si0 2) may be such a case that is used as a Lewis acid include, these hydroxy-ethoxy group of the Lewis base described above to nano-size particles (particle nan o) of the material is to form a coordination complex.
- the nano-size particles described above may have a particle size of about 10 nm to about 1, and such complex compounds are more specifically, for example, in the form of the following structural formula. ⁇
- Me is a Lewis acid in which iron (II) ions, iron (III) ions, strontium (III) ions, and / or calcium (II) ions are used.
- the complex used in the present invention is not necessarily limited to the above-described structural formula, and may be composed of complex compounds having various structures and coordination numbers, depending on the type of Lewis acid and Lewis base used.
- Each galloyl group in the above structural formula may be in the form of a chelate belonging to the same tannic acid or gallic acid molecule, or may belong to another tannic acid or gallic acid molecule and form a crosslink with a neighboring complex compound.
- the complex compounds may be common to each other depending on external conditions such as temperature, ⁇ , etc., in the state of the composition and the state applied to the oral cavity.
- the composition may include the Lewis base and the Lewis acid in a concentration of about img / ml to about lmg / ml, respectively.
- concentration of the Lewis base and the Lewis acid is lower than the above range, the amount of the complex compound to be produced may not be divided, and the coating layer may not be formed.
- the present invention is not necessarily limited thereto, and the concentration of the Lewis base and the Lewis acid may vary depending on the application site and the application conditions when the vaccine is applied for treatment and prevention.
- the composition may preferably comprise the Lewis base and the Lewis acid in a molar ratio of about 0.5: 1 to about 10: 1. If the molar ratio of the Lewis base and the Lewis acid is lower than the above range, the amount of Lewis base may not be sufficient in amount, and thus, a large amount of unshared electron pairs may not be provided to the Lewis acid, and crosslinking may not be formed in a sufficient amount. When the molar ratio of the Lewis base and the Lewis acid is higher than the above range, the amount of Lewis acid, which is the center of the complex compound, may be less, and crosslinking may not be sufficiently formed.
- the composition may preferably have a pH in the range of about 3 to about 8, more preferably in the range of about 6 to about 7.6.
- This pH range is also a range having an acidity similar to the environment in the oral cavity, but the complex compound described above in the pH range is 4 to 10 or 4 coordination.
- ⁇ When ⁇ is lower than the above range, due to the high hydrogen ion concentration, the hydroxyl group of the galloyl group is present in the central Lewis acid of the complex. Failure to provide ligands can lead to problems in which crosslinking cannot be effectively formed.
- ⁇ is higher than the above range, it is likely that the hydroxide ions will provide the lone pair with the above-mentioned Lewis acid due to the high concentration of hydroxide ions.
- PBS phosphate buffered saline
- NaOH sodium hydroxide aqueous solution
- the composition may further comprise separate silica particles.
- the silica particles referred to herein are used as Lewis acids of the composition and are further included separately in addition to the nano-sized silica which forms a complex with tannic acid or gallic acid.
- Silica particles may act as a nucleus for forming a coating layer by a complex compound in the above-described crosslink formation process, and the surface may be coated by the complex compound to fill a loss part of a tooth when a syringe is used for treatment or the like. Can play a role in the body. Silica particles coated on the surface by the above-described complex compound may penetrate into the dentin tubules to block the dentin tubules, and the hydroxyapatite layer described above may be formed to regenerate damaged tooth portions.
- Such silica particles may preferably have a number average particle diameter of about 0.05 m to about 5.
- the number average particle diameter of the silica particles is smaller than the above range, the surface coating may not easily occur due to the complex compound. If the number average particle diameter of the silica particles is larger than the above range, the silica particles may not penetrate into the ivory tubule.
- the present invention is not necessarily limited thereto.
- the silica particles may be preferably included in about 50% by weight or less based on the total composition.
- the calculated ⁇ value is in the range of about 3 to about 25, preferably in the range of about 3 to about 15, more preferably in the range of about 3 to about 6, and is difficult to visually identify before and after treatment. Only the color change may be brought or there may be little color change.
- the AW * value calculated by the following equations (2) and (3) is in the range of about -7 to 20, preferably in the range of about 0 to about 20, more preferably In the range of about 2 to 6, the teeth whitening index is
- composition is aerosol, which can be applied as a solution such as gargle or coating liquid, paste, spray solution, etc. which can be applied as toothpaste or ointment, or
- It may have a formulation in the form of a resin that can be used for application.
- the patient In the case of preparation of the gargle, the patient directly holds the gargle in the mouth for several tens of seconds and then repeats the method of rinsing, thereby easily treating and preventing the syringe.
- Treatment is possible through curing.
- the composition described above as one component of the toothpaste It is possible to treat and prevent symptomatic symptoms by repeating brushing with such toothpaste.
- a method for producing a composition for oral application at least one Lewis base selected from the group comprising tannic acid (tannic acid) and gallic acid (gallic acid); And iron ( ⁇ ) ions, iron (III) ions, strontium (III) ions, calcium (II) ions, titanium dioxide (Ti0 2 ), iron oxide (Fe 2 0 3 ), iron hydroxide (Fe (OH) 2 ) And at least one Lewis acid selected from the group consisting of calcium oxide (CaO), calcium hydroxide (Ca (OH) 2 ), silicon (Si), and silica (Si0 2 ).
- the reaction method is not particularly limited, and for example, after preparing an aqueous solution of each of Lewis base and Lewis acid, the reaction can be advanced simply by mixing and stirring the mixture.
- metal ions when metal ions are used as the Lewis acid described above, various metal salts may be used as precursors for generating the metal ions.
- the Lewis base and the Lewis acid may be preferably reacted by mixing in a molar ratio of 0.5: 1 to 10: 1, and the description of the ratio limitation is as described in the composition.
- the step of reacting may be preferably performed in a pH range of 3 to 7.5, the reason for limiting such pH is also as described in the composition.
- the reaction may be performed under a temperature range of 4 to 60 ° C and a pressure range of 0.1 to 5 atm, and more preferably performed under a temperature range of 15 to 40 ° C and a pressure range of 0.1 to 2 atm. And, it may be most preferably performed under a temperature range of 30 to 40 ° C and a pressure range of 0.5 to 1.5 atm, which is a similar environment as the oral cavity, the present invention is not necessarily limited thereto, It is possible to perform without the constraints of the instrument.
- the silica particles in addition to coating the silica particles with a complex compound that is a product of the reaction It may further comprise a step.
- the coating method is not particularly limited, and for example, the surface-coated silica particles can be obtained only by immersing the aqueous solution of each of the Lewis base and Lewis acid so as to evenly disperse the above-described silica particles in a mixed composition.
- the ivory tubule sealing method comprising the step of forming a coating layer by applying the composition for oral application in the oral cavity exposed to the dentin tube can be provided.
- the method may further include forming a hydroxyapatite layer, which is described above in the description of the composition for oral application.
- a hydroxyapatite layer which is described above in the description of the composition for oral application.
- teeth without caries and restorations were prepared. Extracted teeth were stored in l% chloramine T solution until testing. A tooth specimen was prepared by removing the crown of the tooth using a low-speed diamond rob and cutting it to lmm thickness to expose the dentin. The cut surface was mirror polished up to 3000 mesh using sandpaper, and the specimen was washed in the order of acetone, ethanol and distilled water in an ultrasonic cleaner and dried at room temperature.
- FIG. 1 is an SEM image of various parts of the prepared surface of the dental specimen at different magnifications.
- FIG 1 it can be seen that the ivory tubules are exposed on the surface of the specimen.
- Figure 2 shows different magnifications for various cross sections of the prepared dental specimens. The observed SEM image.
- a composition comprising a complex compound was prepared.
- Silica particles (Sigma Aldrich) having an average particle diameter of 50 to 100 nm were added to the composition prepared in Example 1.
- the silica particles on the right side can be seen that a relatively transparent film is formed on the surface thereof, and this film is formed by depositing a tannic acid-iron (III) complex on the surface of the silica particles. It can be interpreted as forming a coating layer.
- aqueous solution of tannic acid at a concentration of 0.8 mg / ml and an aqueous dispersion of titanium dioxide ( ⁇ 0 2 ) nanoparticles (particle size: 10 nm to 1 ⁇ , manufacturer: Sigma Aldrich) at 0.2 mg / ml were prepared. After mixing 5 ml of each of the aqueous solution and the aqueous dispersion, and then dropping the phosphate buffer solution until the pH is 7 or more, the tannin acid and titanium dioxide nanoparticles A composition comprising a complex compound was prepared.
- Strontium (Sr (N0 3 ) 2 ) aqueous solution was prepared.
- a nanoparticle (particle diameter: 10 nm to ffli, manufacturer: Sigma Aldrich) was prepared with an aqueous dispersion. After mixing 5 ml of each of the aqueous solution and the aqueous dispersion, and then dropping the complete phosphate solution until ⁇ was 7 or more, a composition including a complex compound of tannic acid and silica nanoparticles was prepared.
- aqueous solution of tannin acid at a concentration of 0.8 mg / ml and an aqueous dispersion of iron oxide (Fe 2 O 3 ) nanoparticles (particle size: 10 nm to ⁇ , manufactured by Sigma Aldrich) at a concentration of 0.2 mg / ml were prepared. After mixing 5 ml of each of the aqueous solution and the aqueous dispersion, and then dropping the complete phosphate solution until ⁇ is 7 or more, a composition containing a complex compound of tannic acid and iron oxide nanoparticles was prepared.
- aqueous solution of tannin acid at a concentration of 0.8 mg / ml and a calcium hydroxide (Ca (OH) 2 ) nanoparticle (particle size: 10 nm to 1 // II1, manufactured by Sigma Aldrich) at 0.2 mg / ml were prepared. After mixing 5 ml of each of the aqueous solution and the aqueous dispersion, and then dropping the phosphate buffer solution until ⁇ is 7 or more, the tannin acid and calcium hydroxide nanoparticles
- composition comprising a complex compound was prepared. [Example 1-1 and Examples 3-1 to 7-1]
- Example 1 The same procedure as in Example 1 and Examples 3 to 7 was performed except that an aqueous solution of gallic acid was used instead of an aqueous solution of tannic acid.
- the prepared tooth specimen was immersed in the composition of the above Example for about 1 minute, after immersion, taken out and washed with distilled water. Several immersion washes were repeated four times. Observation of the tooth surface
- salts of calcium chloride (CaCl 2 ), potassium phosphate (potassium phosphate, K 2 HP0 4 ), sodium fluoride (NaF) and sodium chloride (NaCl) were added to the following concentrations, respectively.
- the tooth composition treated with the composition was immersed, put in a rotary incubator and stored at a rate of 37 ° C, 100 rpm for a week. During storage, artificial saliva was refreshed every 24 hours. After 7 days, the specimens were taken out, washed with distilled water, some of them were collected, and the surface and the cross section thereof were observed by SEM.
- Example 3 is an SEM image observed on the surface of the dental specimen treated with the composition of Example 1.
- FIG. 4 is an SEM image of various cross sections of the dental specimen to which the composition of Example 1 is treated.
- the coating filling is formed on the surface of the specimen, to form a uniform height, in particular, as observed in Figure 2, it can be seen that the uneven irregularities due to tooth damage, etc. disappeared (right Prize).
- a lump is formed on the surface of the tooth, which is formed of hydroxyapatite by depositing calcium and phosphorus components of artificial saliva on the coating layer of the tannin-iron (III) complex. It can be confirmed that a layer is formed.
- FIG. 5 is an SEM image of the dentin tubular surface of the dental specimen surface before and after treatment with the composition of Example 1.
- FIG. 7 shows the EDX spectrum of the surface of the dental specimen after treatment of the composition of Example 1.
- Hydroxyapatite layerols collected separately, were measured for EDX spectra for comparison with normal dental specimens and their components.
- Example 8 is produced after the composition treatment of Example 1 and Example 1-1
- the hydroxyapatite layer has a composition similar to that of regular teeth. You can check it.
- 9 to 1 are SEM images observed on the front and cross section of the ivory tubule on the surface of the tooth specimen before and after treatment with the compositions of Examples 1, 3 to 7, 1-1, and 3-1 to 7-1. 9 to 11, when comparing the tooth specimen before the composition treatment and after application, it can be seen that the dentinal tubules on the tooth surface effectively blocked, especially after 7 days of application, a lump is formed on the surface, exposed In addition to the surface of the ivory tubules, the interior of the ivory tubules can be confirmed that the blockage, from which the scab and phosphorus components of artificial saliva are deposited on the coating layer of the complex
- Example 1 The composition of Example 1 was treated to prepare a dental specimen having a hydroxyapatite layer on the coating layer of the tannic acid-iron (III) complex, which had a diameter of about 10 mm and a thickness of about l mm.
- the tooth specimens were subjected to 100 times brushing with a load of 150 g using equipment in accordance with ISO 11609.
- the surface of the specimen was subjected to 100 times brushing with a load of 150 g using equipment in accordance with ISO 11609. The surface of the specimen
- the color change is not severe in the range of about 3 to about 25 in all embodiments, and in particular, in Examples 4 to 6, the color index ⁇ value is in the range of about 3 to about 6 Because of the location, it can be seen that the color change is not so severe that it is difficult for the naked eye to easily identify the color change.
- the AW * value too, in all the ranges of about -20 to about 20, it can be seen that the color change is not severe, especially in the case of Examples 3 to 6 W * value to have a positive value It can be seen that the tooth whitening effect can also be expected by applying the composition of the present invention.
Abstract
La présente invention concerne une composition pour application buccale et le procédé de préparation de celle-ci et, plus particulièrement, une composition pour application buccale contenant un composé complexe formé d'une base de Lewis spécifique et d'un acide de Lewis spécifique, et le procédé de préparation de celle-ci. La composition pour application buccale de la présente invention a une durabilité, une sécurité d'emploi pour l'organisme humain et une capacité de recouvrement excellentes, et peut de ce fait traiter de façon efficace les symptômes de sensibilité dentaire et empêcher l'apparition de symptômes de sensibilité dentaire lorsqu'elle est appliquée avant l'apparition de ces symptômes de sensibilité dentaire.
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RU2805526C2 (ru) * | 2022-02-22 | 2023-10-18 | Общество С Ограниченной Ответственностью "Сплат Глобал" | Синергетическая реминерализующая комбинация |
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WO1999004764A1 (fr) * | 1997-07-23 | 1999-02-04 | Perio Products Ltd. | Compositions d'acide tannique et de polymeres pour la liberation contrôlee d'agents pharmaceutiques, notamment dans la cavite buccale |
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WO1999004764A1 (fr) * | 1997-07-23 | 1999-02-04 | Perio Products Ltd. | Compositions d'acide tannique et de polymeres pour la liberation contrôlee d'agents pharmaceutiques, notamment dans la cavite buccale |
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RU2805526C2 (ru) * | 2022-02-22 | 2023-10-18 | Общество С Ограниченной Ответственностью "Сплат Глобал" | Синергетическая реминерализующая комбинация |
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