WO2015161832A1 - Protéine de fusion recombinante à action prolongée d'interféron humain α2b-fc - Google Patents
Protéine de fusion recombinante à action prolongée d'interféron humain α2b-fc Download PDFInfo
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- WO2015161832A1 WO2015161832A1 PCT/CN2015/077504 CN2015077504W WO2015161832A1 WO 2015161832 A1 WO2015161832 A1 WO 2015161832A1 CN 2015077504 W CN2015077504 W CN 2015077504W WO 2015161832 A1 WO2015161832 A1 WO 2015161832A1
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- Prior art keywords
- fusion protein
- long
- human interferon
- recombinant human
- acting recombinant
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/56—IFN-alpha
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Toxicology (AREA)
- Mycology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
L'invention concerne une protéine de fusion d'interféron humain α2b-Fc, l'extrémité C de l'interféron humain α2b étant reliée à l'extrémité N de Fc par un segment de liaison peptidique. La présente invention concerne une séquence d'acide nucléique codant pour la protéine de fusion et un système d'expression eucaryote exprimant la protéine de fusion. L'invention concerne également une utilisation de la protéine de fusion dans la préparation d'un médicament antitumoral ou antiviral. La protéine de fusion présente une activité antivirale améliorée et une demi-vie in vivo prolongée.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410170133.3 | 2014-04-25 | ||
| CN201410170133 | 2014-04-25 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2015161832A1 true WO2015161832A1 (fr) | 2015-10-29 |
| WO2015161832A8 WO2015161832A8 (fr) | 2016-03-17 |
Family
ID=54331779
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/CN2015/077504 WO2015161832A1 (fr) | 2014-04-25 | 2015-04-27 | Protéine de fusion recombinante à action prolongée d'interféron humain α2b-fc |
Country Status (1)
| Country | Link |
|---|---|
| WO (1) | WO2015161832A1 (fr) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1206350A (zh) * | 1995-12-28 | 1999-01-27 | 泰诺克斯生物系统公司 | 具有经非免疫原性肽连接在一起的干扰素α和免疫球蛋白Fc的杂合体 |
-
2015
- 2015-04-27 WO PCT/CN2015/077504 patent/WO2015161832A1/fr active Application Filing
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1206350A (zh) * | 1995-12-28 | 1999-01-27 | 泰诺克斯生物系统公司 | 具有经非免疫原性肽连接在一起的干扰素α和免疫球蛋白Fc的杂合体 |
Non-Patent Citations (1)
| Title |
|---|
| WANG, LEI ET AL.: "Enhanced Circulation Half-life for Human IFNa2b and IgG Fc Fusion Protein", CHINESE JOURNAL OF BIOTECHNOLOGY, vol. 24, no. 1, 25 January 2008 (2008-01-25), XP008134213 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2015161832A8 (fr) | 2016-03-17 |
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