WO2015154731A1 - Formulation sous la forme d'une suspension pour le traitement d'un parasite hématophage - Google Patents

Formulation sous la forme d'une suspension pour le traitement d'un parasite hématophage Download PDF

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Publication number
WO2015154731A1
WO2015154731A1 PCT/CZ2015/000033 CZ2015000033W WO2015154731A1 WO 2015154731 A1 WO2015154731 A1 WO 2015154731A1 CZ 2015000033 W CZ2015000033 W CZ 2015000033W WO 2015154731 A1 WO2015154731 A1 WO 2015154731A1
Authority
WO
WIPO (PCT)
Prior art keywords
suspension solution
fact
substances
tick
mixtures
Prior art date
Application number
PCT/CZ2015/000033
Other languages
English (en)
Inventor
Bohuslav Dolezal
Jan DOLEZAL
Original Assignee
Vakos Xt A.S.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vakos Xt A.S. filed Critical Vakos Xt A.S.
Priority to EP15720897.6A priority Critical patent/EP3128837A1/fr
Publication of WO2015154731A1 publication Critical patent/WO2015154731A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
    • A01N59/12—Iodine, e.g. iodophors; Compounds thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
    • A01N31/08—Oxygen or sulfur directly attached to an aromatic ring system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
    • A01N31/08—Oxygen or sulfur directly attached to an aromatic ring system
    • A01N31/16—Oxygen or sulfur directly attached to an aromatic ring system with two or more oxygen or sulfur atoms directly attached to the same aromatic ring system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
    • A01N33/02—Amines; Quaternary ammonium compounds
    • A01N33/12—Quaternary ammonium compounds
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N35/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical
    • A01N35/02—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical containing aliphatically bound aldehyde or keto groups, or thio analogues thereof; Derivatives thereof, e.g. acetals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/16—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group; Thio analogues thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/36—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids
    • A01N37/38—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids having at least one oxygen or sulfur atom attached to an aromatic ring system
    • A01N37/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids having at least one oxygen or sulfur atom attached to an aromatic ring system having at least one carboxylic group or a thio analogue, or a derivative thereof, and one oxygen or sulfur atom attached to the same aromatic ring system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
    • A01N47/42—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=CX2 groups, e.g. isothiourea
    • A01N47/44—Guanidine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
    • A01N59/14—Boron; Compounds thereof

Definitions

  • the invention relates to a formulation which contains a suspension solution of substances or their compounds in water, alcohols and other volatile solvents or their mixtures, with the content of acrylate copolymer and/or nitrocellulose for incapacitating, dehydrating, rapid killing and disinfection of a blood-sucking and firmly stuck parasite, i.e. in particular a tick or a leech, and its easy and safe removal from the place of sticking of a host.
  • the said formulation can be used for efficient disinfecting of the given parasite itself.
  • Formulations or methods used for removing a blood-sucking and firmly stuck parasite, in particular a tick or a leech are usually amateur ones (e.g. by shaking out, tearing off etc.), or lengthy and with locally limited usability (e.g. a plaster with a disinfection formulation which is hard-to-be-applied in body folders, hair etc., which are commonly the most frequently occurring places of sticking for a tick).
  • This "amateur" method may result in residues of the removed parasite remaining in the place of sticking, which may consequently result in the importation of infection into the host's body.
  • One of the other known methods for removing a stuck tick is its removal by means of a special card with slots without prior application of any formulations on the place of sticking.
  • the attached special card firmly catches hold of the tick and pulls it out without squeezing the tick and pushing out the content of its intestines into the wound.
  • user instructions 2 being attached to the card, it is problematic whether the removing person is skilful enough to remove it without problems, in particular at parts of the body which are difficult to reach.
  • Another common method is applying an oil or any fat on the place with the tick, when the greased tick is stifled and consequently removed. There is a high risk in this method that the content of tick's intestines can be thrown out directly to the host's wound before its death.
  • Another solution for removing a tick is using alcohol, water- alcohol and other solutions of iodine and/or its compounds with the addition of suitable substances which are able to polymerize.
  • a disinfection solution modified in this way a many times higher quantity of an active disinfection substance is applied on the tick as well as on the affected place, and at the same time the formed film of polymerizing substances significantly slows down the evaporation of the solvent and prolongs the contact time of the disinfection substance (still present in the liquid state) with the tick and the skin, which results in prolonging the disinfecting effect.
  • the advantage of this method is an easier application on any place of the skin.
  • a disadvantage of this application is the fact that after evaporation of volatile substances and completed polymerization, the lodged tick and the surrounding area, where the formulation was applied, remain covered with a dried residue of the formulation which is firmly stuck on the skin and causes problems when removed from the skin.
  • the subject-matter of the invention is a formulation containing a suspension solution of substances with disinfecting effect or their compounds in water, alcohols and other volatile solvents or mixtures thereof, with the content of acrylate copolymer and/or nitrocellulose for incapacitating, dehydrating, rapid killing and disinfection of a blood-sucking firmly stuck parasite and its easy removal from the place of sticking of the host, which contains up to 25 % by weight of the powder form of a solid inert substance and/or a mixture of solid inert substances based on the weight of all ingredients of the suspension solution, with the specific area of at least 1 m 2 /g.
  • a firmly stuck parasite is preferably a tick or a leech.
  • the formulation is a solution of substances with disinfecting effect and moreover, the composition of this formulation contains a powder form of solid inert substances (fillers) and/or mixtures of these solid inert substances, which can be contained up to 25 % by weight based on the weight of all the ingredients of the suspension solution, where their specific area is at least 1 m 2 /g.
  • fillers solid inert substances
  • mixtures of these solid inert substances which can be contained up to 25 % by weight based on the weight of all the ingredients of the suspension solution, where their specific area is at least 1 m 2 /g.
  • the formulation according to the present invention has also strong dehydrating effects which results in all the liquids contained in the tick being absorbed in the applied formulation, which is another cause avoiding the entry of tick's body liquids into the wound.
  • the killed, dehydrated and disinfected tick or leech can be easily removed using a pair of tweezers or other suitable manner.
  • the suitable design of this invention is the formulation which contains up to 25 w% of the powder form of a solid inert substance, related to the weight of all the ingredients of the suspension solution and or the mixture of solid inert substances with a high specific area (i.e. a low weight in volume), of at least 100 m 2 /g.
  • Suitable inert substances according to this invention are powder forms of inert substances, i.e. fine powders of inorganic oxides such as SiCVaerosil, ⁇ 1 2 ⁇ 3, or inorganic pigments such as Ti0 2 , or Si0 2 obtained in the chemical way (usually by pyrohydrolysis from volatile chlorides), a fine ground or precipitated calcium carbonate, magnesium carbonate, calcium- magnesium carbonate - dolomite, dialumino silicates, magnesium dialumosilicates such as magnesium aluminate metasilicate, chalk, talk, calcium phosphate, calcium silicate, bergmeal, mineral powder, quartz powder, porcelain clay, apatite, bentonite, perlite, vermiculite or their mixtures.
  • Particularly suitable inert substances are Si0 2 -aerosil, bentonite or powdered Ti0 2 .
  • suitable disinfection substances are, in the reasonable quantity, iodine and its compounds (i.e. with potassium iodide or sodium iodide, iodine- povidon, iodine-phenol), and
  • aldehydes (formaldehyde, glutaraldehyde, ortho-phthalaldehyde),
  • quaternary ammonium salts (benzododecinium salts, carbetopendecinium salts, cetrimide), chlorhexidine digluconate,
  • boric acid salicylic acid, peroxo-acetic acid, peroxo-formic acid, potassium hydrogen peroxo sulphate,
  • ethanol can be used as a solvent
  • diethyl ether contained according to the background art according to the CZ 20342 Ul utility model can be partly or fully replaced with similar, less volatile substances, e.g. propanol or isopropanol and methyl tertiary butyl ether.
  • the used solution of nitrocellulose in diethyl ether can be replaced according to this technical solution with a suspension water-alcohol gel with similar effect on incapacitating, dehydrating, disinfection and killing a tick.
  • Example 9 A suspension solution containing 37.5 w% of diethyl ether, 36.5 w% of ethanol, 5 w% of nitrocellulose and 1 w% of phenol, containing 20 w% of chemically precipitated CaC0 3
  • the tick or the leech were very quickly incapacitated, dehydrated and consequently killed in all of these cases, the tick or the leech as well as the wound were disinfected and the residue of the formulation was easily crumbled away and the tick or the leech easily removed.
  • the formulation is intended for the rapid incapacitation, killing and dehydration of a tick and concurrent efficient disinfection of the tick itself.

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Plant Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Pest Control & Pesticides (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

L'invention concerne une formulation contenant une suspension de substances ayant un effet de désinfection ou des composés de ces dernières dans de l'eau, des alcools et d'autres solvants volatils ou des mélanges de ces derniers, avec un copolymère acrylate et/ou de la nitrocellulose pour la neutralisation, l'extermination et la désinfection rapide d'un parasite hématophage ancré solidement, qui est, de préférence, une tique ou une sangsue, et son retrait facile de l'emplacement d'ancrage de l'hôte. Ladite suspension contient jusqu'à 25 % en poids de la forme pulvérulente d'une substance inerte solide et/ou d'un mélange de substances inertes solides sur la base du poids de tous les constituants de la suspension, avec la surface spécifique d'au moins 1 m2/g.
PCT/CZ2015/000033 2014-04-09 2015-04-09 Formulation sous la forme d'une suspension pour le traitement d'un parasite hématophage WO2015154731A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP15720897.6A EP3128837A1 (fr) 2014-04-09 2015-04-09 Formulation sous la forme d'une suspension pour le traitement d'un parasite hématophage

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CZPV2014-240 2014-04-09
CZ2014-240A CZ306491B6 (cs) 2014-04-09 2014-04-09 Prostředek obsahující suspenzní roztok látek s dezinfekčním účinkem pro zneschopnění, dehydrataci, rychlé usmrcení, dezinfekci a jednoduché odstranění krev sajícího a pevně přisátého parazita

Publications (1)

Publication Number Publication Date
WO2015154731A1 true WO2015154731A1 (fr) 2015-10-15

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ID=53054815

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CZ2015/000033 WO2015154731A1 (fr) 2014-04-09 2015-04-09 Formulation sous la forme d'une suspension pour le traitement d'un parasite hématophage

Country Status (3)

Country Link
EP (1) EP3128837A1 (fr)
CZ (1) CZ306491B6 (fr)
WO (1) WO2015154731A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108129547A (zh) * 2017-11-21 2018-06-08 齐鲁工业大学 一种提取菌胶团胞外聚合物的方法
CN112640913A (zh) * 2020-12-30 2021-04-13 佛山市正典生物技术有限公司 一种具有长期组分稳定性的含碘消毒剂及其制备方法
CN112806387A (zh) * 2020-12-31 2021-05-18 佛山市正典生物技术有限公司 一种组分含量稳定的含碘消毒剂的制备方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003003998A1 (fr) * 2001-07-06 2003-01-16 Stockhausen Gmbh & Co. Kg Peocede de production de gels de soin desinfectants conçus pour la peau et les mains
EP1769824A1 (fr) * 2005-09-22 2007-04-04 Nof Corporation Gel désinfectant à séchage rapide pour les mains
CZ20342U1 (cs) 2009-11-05 2009-12-07 Vakos Xt A.S. Přípravek k rychlému usmrcení klíštěte a účinné dezinfekci místa přisátí na bázi jodu
CN102450253A (zh) * 2010-10-15 2012-05-16 华北制药集团爱诺有限公司 阿维菌素水悬浮剂及其制备方法
JP2013253021A (ja) * 2012-06-05 2013-12-19 Ikejiri Pharmaceutical Co Ltd 殺菌消毒剤

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040067247A1 (en) * 2002-09-27 2004-04-08 Xavier De Sloovere Composition for combating/repelling insects, birds, dirts and parasites
US20040062783A1 (en) * 2002-09-27 2004-04-01 Xavier De Sloovere Composition for combating insects and parasites
CZ27167U1 (cs) * 2013-11-27 2014-07-14 Vetrisol, S.R.O. Přípravek k rychlému usmrcení a bezpečnému odstranění přisátého klíštěte

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003003998A1 (fr) * 2001-07-06 2003-01-16 Stockhausen Gmbh & Co. Kg Peocede de production de gels de soin desinfectants conçus pour la peau et les mains
EP1769824A1 (fr) * 2005-09-22 2007-04-04 Nof Corporation Gel désinfectant à séchage rapide pour les mains
CZ20342U1 (cs) 2009-11-05 2009-12-07 Vakos Xt A.S. Přípravek k rychlému usmrcení klíštěte a účinné dezinfekci místa přisátí na bázi jodu
CN102450253A (zh) * 2010-10-15 2012-05-16 华北制药集团爱诺有限公司 阿维菌素水悬浮剂及其制备方法
JP2013253021A (ja) * 2012-06-05 2013-12-19 Ikejiri Pharmaceutical Co Ltd 殺菌消毒剤

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108129547A (zh) * 2017-11-21 2018-06-08 齐鲁工业大学 一种提取菌胶团胞外聚合物的方法
CN108129547B (zh) * 2017-11-21 2021-01-05 齐鲁工业大学 一种提取菌胶团胞外聚合物的方法
CN112640913A (zh) * 2020-12-30 2021-04-13 佛山市正典生物技术有限公司 一种具有长期组分稳定性的含碘消毒剂及其制备方法
CN112640913B (zh) * 2020-12-30 2022-02-22 佛山市正典生物技术有限公司 一种具有长期组分稳定性的含碘消毒剂及其制备方法
CN112806387A (zh) * 2020-12-31 2021-05-18 佛山市正典生物技术有限公司 一种组分含量稳定的含碘消毒剂的制备方法
CN112806387B (zh) * 2020-12-31 2022-02-25 佛山市正典生物技术有限公司 一种组分含量稳定的含碘消毒剂的制备方法

Also Published As

Publication number Publication date
CZ306491B6 (cs) 2017-02-15
CZ2014240A3 (cs) 2015-10-21
EP3128837A1 (fr) 2017-02-15

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